WO2024045066A1 - Carbamate d'alkylidène en tant qu'inhibiteurs de kras - Google Patents
Carbamate d'alkylidène en tant qu'inhibiteurs de kras Download PDFInfo
- Publication number
- WO2024045066A1 WO2024045066A1 PCT/CN2022/116281 CN2022116281W WO2024045066A1 WO 2024045066 A1 WO2024045066 A1 WO 2024045066A1 CN 2022116281 W CN2022116281 W CN 2022116281W WO 2024045066 A1 WO2024045066 A1 WO 2024045066A1
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- WO
- WIPO (PCT)
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- heterocyclyl
- hydrogen
- Prior art date
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- -1 Alkylidene carbamate Chemical compound 0.000 title claims description 307
- 229940124785 KRAS inhibitor Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 453
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- 238000000034 method Methods 0.000 claims abstract description 30
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 161
- 239000001257 hydrogen Substances 0.000 claims description 161
- 125000000623 heterocyclic group Chemical group 0.000 claims description 153
- 125000000217 alkyl group Chemical group 0.000 claims description 135
- 150000002431 hydrogen Chemical class 0.000 claims description 124
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- 125000005843 halogen group Chemical group 0.000 claims description 92
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- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 81
- 229910052805 deuterium Inorganic materials 0.000 claims description 81
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 73
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne certains composés de carbamate d'alkylidényle qui inhibent certaines protéines K-Ras et sont par conséquent utiles pour le traitement de cancers médiés par de telles protéines. L'invention concerne également des compositions pharmaceutiques contenant de tels composés et des procédés de préparation de tels composés.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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PCT/CN2022/116281 WO2024045066A1 (fr) | 2022-08-31 | 2022-08-31 | Carbamate d'alkylidène en tant qu'inhibiteurs de kras |
PCT/CN2023/116008 WO2024046406A1 (fr) | 2022-08-31 | 2023-08-31 | Carbamate d'alkylidène en tant qu'inhibiteurs de kras |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/CN2022/116281 WO2024045066A1 (fr) | 2022-08-31 | 2022-08-31 | Carbamate d'alkylidène en tant qu'inhibiteurs de kras |
Publications (1)
Publication Number | Publication Date |
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WO2024045066A1 true WO2024045066A1 (fr) | 2024-03-07 |
Family
ID=90100002
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2022/116281 WO2024045066A1 (fr) | 2022-08-31 | 2022-08-31 | Carbamate d'alkylidène en tant qu'inhibiteurs de kras |
PCT/CN2023/116008 WO2024046406A1 (fr) | 2022-08-31 | 2023-08-31 | Carbamate d'alkylidène en tant qu'inhibiteurs de kras |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2023/116008 WO2024046406A1 (fr) | 2022-08-31 | 2023-08-31 | Carbamate d'alkylidène en tant qu'inhibiteurs de kras |
Country Status (1)
Country | Link |
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WO (2) | WO2024045066A1 (fr) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020146613A1 (fr) * | 2019-01-10 | 2020-07-16 | Mirati Therapeutics, Inc. | Inhibiteurs de kras g12c |
WO2022042630A1 (fr) * | 2020-08-26 | 2022-03-03 | InventisBio Co., Ltd. | Composés hétéroaryle, leurs procédés de préparation et leurs utilisations |
WO2022061251A1 (fr) * | 2020-09-18 | 2022-03-24 | Plexxikon Inc. | Composés et procédés pour la modulation de kras et leurs indications |
WO2022068921A1 (fr) * | 2020-09-30 | 2022-04-07 | 上海医药集团股份有限公司 | Composé quinazoline et son application |
CN114615981A (zh) * | 2019-08-29 | 2022-06-10 | 米拉蒂治疗股份有限公司 | Kras g12d抑制剂 |
WO2022173870A1 (fr) * | 2021-02-09 | 2022-08-18 | Kumquat Biosciences Inc. | Composés hétérocycliques et leurs utilisations |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4182313A1 (fr) * | 2020-07-16 | 2023-05-24 | Mirati Therapeutics, Inc. | Inhibiteurs de kras g12d |
WO2023284730A1 (fr) * | 2021-07-14 | 2023-01-19 | Nikang Therapeutics, Inc. | Dérivés d'alkylidène en tant qu'inhibiteurs de kras |
WO2023283933A1 (fr) * | 2021-07-16 | 2023-01-19 | Silexon Biotech Co., Ltd. | Composés utiles en tant qu'inhibiteurs de kras g12d |
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2022
- 2022-08-31 WO PCT/CN2022/116281 patent/WO2024045066A1/fr unknown
-
2023
- 2023-08-31 WO PCT/CN2023/116008 patent/WO2024046406A1/fr unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020146613A1 (fr) * | 2019-01-10 | 2020-07-16 | Mirati Therapeutics, Inc. | Inhibiteurs de kras g12c |
CN114615981A (zh) * | 2019-08-29 | 2022-06-10 | 米拉蒂治疗股份有限公司 | Kras g12d抑制剂 |
WO2022042630A1 (fr) * | 2020-08-26 | 2022-03-03 | InventisBio Co., Ltd. | Composés hétéroaryle, leurs procédés de préparation et leurs utilisations |
WO2022061251A1 (fr) * | 2020-09-18 | 2022-03-24 | Plexxikon Inc. | Composés et procédés pour la modulation de kras et leurs indications |
WO2022068921A1 (fr) * | 2020-09-30 | 2022-04-07 | 上海医药集团股份有限公司 | Composé quinazoline et son application |
WO2022173870A1 (fr) * | 2021-02-09 | 2022-08-18 | Kumquat Biosciences Inc. | Composés hétérocycliques et leurs utilisations |
Also Published As
Publication number | Publication date |
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WO2024046406A1 (fr) | 2024-03-07 |
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