WO2024040267A3 - Direct synthesis of n-(3-substituted-chroman-4-yl)-7h- pyrrolo[2,3-d]pyrimidin-4-amines and derivatives thereof - Google Patents

Direct synthesis of n-(3-substituted-chroman-4-yl)-7h- pyrrolo[2,3-d]pyrimidin-4-amines and derivatives thereof Download PDF

Info

Publication number
WO2024040267A3
WO2024040267A3 PCT/US2023/072592 US2023072592W WO2024040267A3 WO 2024040267 A3 WO2024040267 A3 WO 2024040267A3 US 2023072592 W US2023072592 W US 2023072592W WO 2024040267 A3 WO2024040267 A3 WO 2024040267A3
Authority
WO
WIPO (PCT)
Prior art keywords
chroman
pyrrolo
pyrimidin
substituted
amines
Prior art date
Application number
PCT/US2023/072592
Other languages
French (fr)
Other versions
WO2024040267A2 (en
Inventor
Nicholas Thomas Hertz
Robert Devita
Paul O'shea
Lorna Duffy
Abid Suleman
Johan BARTHOLOMEUS
Philippe MCGEE
Julien DANSEREAU
Jeffrey SANTANDREA
Original Assignee
Mitokinin, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitokinin, Inc. filed Critical Mitokinin, Inc.
Publication of WO2024040267A2 publication Critical patent/WO2024040267A2/en
Publication of WO2024040267A3 publication Critical patent/WO2024040267A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present disclosure is directed to N-(3-substituted-chroman-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine compounds useful as PINK1 modulators, compounds useful in preparing N-(3-substituted-chroman-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine compounds, and methods of making and using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
PCT/US2023/072592 2022-08-19 2023-08-21 Direct synthesis of n-(3-substituted-chroman-4-yl)-7h- pyrrolo[2,3-d]pyrimidin-4-amines and derivatives thereof WO2024040267A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263399504P 2022-08-19 2022-08-19
US63/399,504 2022-08-19

Publications (2)

Publication Number Publication Date
WO2024040267A2 WO2024040267A2 (en) 2024-02-22
WO2024040267A3 true WO2024040267A3 (en) 2024-03-21

Family

ID=89942363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/072592 WO2024040267A2 (en) 2022-08-19 2023-08-21 Direct synthesis of n-(3-substituted-chroman-4-yl)-7h- pyrrolo[2,3-d]pyrimidin-4-amines and derivatives thereof

Country Status (1)

Country Link
WO (1) WO2024040267A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112972A (en) * 1989-06-02 1992-05-12 Merck Patent Gesellschaft Mit Beschrankter Haftung Synthesis of chroman derivatives
US6156748A (en) * 1996-10-07 2000-12-05 Eli Lilly And Company Compounds useful as neuro-protective agents
US6660752B2 (en) * 2001-04-23 2003-12-09 Bayer Pharmaceuticals Corporation 2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists
US20170283389A1 (en) * 2014-09-10 2017-10-05 System Biologie Ag Synthesis of Isoflavanes and Intermediates Thereof
WO2023023670A1 (en) * 2021-08-20 2023-02-23 Mitokinin, Inc. Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112972A (en) * 1989-06-02 1992-05-12 Merck Patent Gesellschaft Mit Beschrankter Haftung Synthesis of chroman derivatives
US6156748A (en) * 1996-10-07 2000-12-05 Eli Lilly And Company Compounds useful as neuro-protective agents
US6660752B2 (en) * 2001-04-23 2003-12-09 Bayer Pharmaceuticals Corporation 2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists
US20170283389A1 (en) * 2014-09-10 2017-10-05 System Biologie Ag Synthesis of Isoflavanes and Intermediates Thereof
WO2023023670A1 (en) * 2021-08-20 2023-02-23 Mitokinin, Inc. Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM COMPOUND 13 September 2017 (2017-09-13), ANONYMOUS: "3-hydroxy-4[3,4-dihydro-3-oxo-2h1,4-benzoxazin-4-yl]-2,2- dimethyldihydro-2h-benzopyran", XP093153089, Database accession no. 341800474 *
DATABASE PUBCHEM COMPOUND 18 January 2016 (2016-01-18), ANONYMOUS: "SID 287838683", XP093153081, retrieved from PUBCHEM Database accession no. 287838683 *
DATABASE PUBCHEM COMPOUND 5 January 2010 (2010-01-05), ANONYMOUS: "SID 86727902", XP093153086, retrieved from PUBCHEM Database accession no. 86727902 *

Also Published As

Publication number Publication date
WO2024040267A2 (en) 2024-02-22

Similar Documents

Publication Publication Date Title
CA2520898A1 (en) Non-cross-linking pyrrolo(2,1-c)(1,4)benzodiazepines as potential antitumour agents and process thereof
TWI265925B (en) Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
WO2007012953A3 (en) Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis
WO2018081417A3 (en) PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
CA2262421A1 (en) Substituted pyrrolopyrimidines and processes for their preparation
NZ590922A (en) Piperidine derivatives as jak3 inhibitors
UA92756C2 (en) Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (crf) receptor antagonists
WO2012085665A8 (en) Novel processes for preparing triazolo[4,5-d]pyrimidine derivatives and intermediates thereof
WO2009151997A8 (en) Process for producing bicycloaniline derivatives
NO20075232L (en) Process for the preparation of pyrido [2,3-d] pyrimidin-7-one and 3,4-dihydropyrimido [4,5-d] pyrimidin-2 (1H) -one derivatives
CA2010588A1 (en) Substituted pyrimidine derivatives, their uses and a process for the preparation thereof
IL152776A (en) Triazolo pyrimidine compounds and process for their preparation
CA2305926A1 (en) Stable crystalline salts of 5-methyltetrahydrofolic acid
CA2395050A1 (en) N-(5,7-dimethoxy[1,2,4]triazolo[1,5-a]pyrimidin-2-yl) arylsulfonamide compounds and their use as herbicides
WO2006105372A3 (en) Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
GEP20135780B (en) Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer agents
WO2001062760A3 (en) A NOVEL CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR
WO2004072030A3 (en) Process for preparing pyrrolotriazine kinase inhibitors
MA29623B1 (en) PYRAZOLO [3, 4-D] AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS
WO2004106340A3 (en) 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO [3,4-d] PYRIMIDINE AND PYRROLO [2,3-d] PYRIMIDINE AND USES THEREOF
WO2024040267A3 (en) Direct synthesis of n-(3-substituted-chroman-4-yl)-7h- pyrrolo[2,3-d]pyrimidin-4-amines and derivatives thereof
ATE517622T1 (en) SALT OF A TETRAHYDROPYRANYLCYCLOPENTYLTETRAHYDROPYRIDOPYR DIDERIVATE AS A CCR-2 ANTAGONIST
AR073248A1 (en) PROCESS FOR THE PREPARATION OF (1S, 2R) -3- ((4-AMINOFENIL) SULFONIL) (ISOBUTIL) AMINO) -1- BENCIL-2- HYDROXYPROPYL CARBAMATE (3R, 3AS, 6AR) - HEXAHYDROFIDE- (2,3- B) FURAN-3- ILO (DARUNAVIR) AND USEFUL INTERMEDIATE COMPOUNDS IN THIS PROCESS.
WO2004005289A3 (en) Efficient synthesis of pyropheophorbide a and its derivatives
MX2022012437A (en) Methods for preparing tyrosine receptor kinase inhibitors.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23855743

Country of ref document: EP

Kind code of ref document: A2