WO2024036184A3 - A human vh-based scaffold for the production of single domain antibodies and their use - Google Patents

A human vh-based scaffold for the production of single domain antibodies and their use Download PDF

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Publication number
WO2024036184A3
WO2024036184A3 PCT/US2023/071893 US2023071893W WO2024036184A3 WO 2024036184 A3 WO2024036184 A3 WO 2024036184A3 US 2023071893 W US2023071893 W US 2023071893W WO 2024036184 A3 WO2024036184 A3 WO 2024036184A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
production
single domain
domain antibodies
based scaffold
Prior art date
Application number
PCT/US2023/071893
Other languages
French (fr)
Other versions
WO2024036184A2 (en
Inventor
Joseph JARDINE
Laetitia MINDREBO
Original Assignee
International Aids Vaccine Initiative
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Aids Vaccine Initiative filed Critical International Aids Vaccine Initiative
Publication of WO2024036184A2 publication Critical patent/WO2024036184A2/en
Publication of WO2024036184A3 publication Critical patent/WO2024036184A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1002—Coronaviridae
    • C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Provided herein are a human VH-based scaffold for the production of single domain antibodies and their use.
PCT/US2023/071893 2022-08-10 2023-08-09 A human vh-based scaffold for the production of single domain antibodies and their use WO2024036184A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263396782P 2022-08-10 2022-08-10
US63/396,782 2022-08-10

Publications (2)

Publication Number Publication Date
WO2024036184A2 WO2024036184A2 (en) 2024-02-15
WO2024036184A3 true WO2024036184A3 (en) 2024-04-18

Family

ID=89852469

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/071893 WO2024036184A2 (en) 2022-08-10 2023-08-09 A human vh-based scaffold for the production of single domain antibodies and their use

Country Status (1)

Country Link
WO (1) WO2024036184A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021048725A1 (en) * 2019-09-12 2021-03-18 Biotheus Inc. Anti-pd-l1 single-domain antibody and derivatives and use thereof
WO2021226405A1 (en) * 2020-05-06 2021-11-11 International Aids Vaccine Initiative Inc. Covid-19 antibodies and uses thereof
US20210355197A1 (en) * 2018-10-22 2021-11-18 International Aids Vaccine Initiative Anti-hiv antibodies
US20210395346A1 (en) * 2020-06-22 2021-12-23 Seoul National University R&Db Foundation Stereotypic neutralizing vh clonotypes against sars-cov-2 rbd in covid-19 patients and the healthy population

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210355197A1 (en) * 2018-10-22 2021-11-18 International Aids Vaccine Initiative Anti-hiv antibodies
WO2021048725A1 (en) * 2019-09-12 2021-03-18 Biotheus Inc. Anti-pd-l1 single-domain antibody and derivatives and use thereof
WO2021226405A1 (en) * 2020-05-06 2021-11-11 International Aids Vaccine Initiative Inc. Covid-19 antibodies and uses thereof
US20210395346A1 (en) * 2020-06-22 2021-12-23 Seoul National University R&Db Foundation Stereotypic neutralizing vh clonotypes against sars-cov-2 rbd in covid-19 patients and the healthy population

Also Published As

Publication number Publication date
WO2024036184A2 (en) 2024-02-15

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