WO2024033692A1 - A method for customized synthetic block graft with 3-dimensional stereolithography - Google Patents

A method for customized synthetic block graft with 3-dimensional stereolithography Download PDF

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Publication number
WO2024033692A1
WO2024033692A1 PCT/IB2022/057549 IB2022057549W WO2024033692A1 WO 2024033692 A1 WO2024033692 A1 WO 2024033692A1 IB 2022057549 W IB2022057549 W IB 2022057549W WO 2024033692 A1 WO2024033692 A1 WO 2024033692A1
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WIPO (PCT)
Prior art keywords
bone
graft
patient
implant
jaw
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PCT/IB2022/057549
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French (fr)
Inventor
Vida ESKANDAMEJAD
Kaamel JALALI
Sepideh SHAHMORADI
Naeemeh PEIDAVOSI
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Eskandamejad Vida
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Application filed by Eskandamejad Vida filed Critical Eskandamejad Vida
Priority to PCT/IB2022/057549 priority Critical patent/WO2024033692A1/en
Publication of WO2024033692A1 publication Critical patent/WO2024033692A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/101—Computer-aided simulation of surgical operations
    • A61B2034/105—Modelling of the patient, e.g. for ligaments or bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30948—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30952—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using CAD-CAM techniques or NC-techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite

Definitions

  • the invention relates to the technical field of biomedical engineering in synthetic customized bone graft.
  • Background Art Implant for maxillofacial bone defect repair, and preparation method of implant filed in China whit 201910539243.5 application number.
  • the invention discloses an implant for maxillofacial bone defect repair, and a preparation method of the implant.
  • the implant structurally comprises a fixing unit and a porous structure part; the porous structure part is integrally connected with the fixing unit; the fixing unit comprises a screw hole and a first through hole; the fixing unit is matched with a healthy residual bone in shape; the porous structure part is located in the middle of the fixing unit and comprises a second through hole and an implant reserved socket; the porous structure part is filled in a maxillofacial disease bonearea or defect area; and the shape and size of the porous structure part are matched with the jaw anatomical structure of the maxillofacial disease bone area or defect area.
  • Customized TCP block graft is a synthetic graft that is compelled with patient bone in specific parts of the body like the jaws bone.
  • Three-dimensional computerized tomogram and intraoral scanners can provide a pattern of specific ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ bone in next step milling devices cuts block grafts and make them fit for the patient's specific parts of the body.
  • the jaw bone is located in the face, the lower 2/3 region, which constitutes an important bone scaffold for the face profile of the jaw, which is one of the important tissues of the face of the human jaw. Maxillofacial defects caused by congenital development malformation, trauma, tumor or other diseases often disrupt the continuity and integrity of the jaw bone, causing the patient to chew, speech, etc. while affecting the patient's face.
  • the method of jaw bone defect reconstruction mainly includes autologous bone grafting, bone replacement implant filling, traction osteotomy, bone tissue engineering, and the like.
  • the autologous bone graft is one method of jaw bone repair and reconstruction, and the method is a method for filling a defect area through bone tissue transplantation of a self-body health site, and fixing and promoting healing
  • the method has the advantages that the bone membrane and the bone marrow are dual supply of blood, the infection resistance is strong, the survival rate is high, but the defect is that: Repair reconstruction after some malignant tumor surgery is not suitable for bone grafting methods, because radiotherapy and chemotherapy can cause the bone healing of a surgical site to be affected.
  • Bone replacement implant filling is another repair method commonly used for maxillofacial surgery.
  • the main polymer synthetic material ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ such as polymethyl methacrylate, high-density polyethylene, polysulfone, and inorganic materials such as hydroxyapatite, calcium sulfate complex, calcium aluminum ceramic, etc.
  • the present invention has the advantages that: the modulus and mechanical properties of the traditional substitute are difficult to be compatible with the bone tissue, and the phenomenon of "stress shielding effect" or insufficient force bearing due to mismatch of the implant and the bone tissue modulus is often avoided.
  • Traction osteotomy is by pulling the device, enabling the cut bone tissue to obtain a slow and stable continuous traction and tension, activating the proliferation function of the cell, thereby facilitating the generation of new bone between the truncated bones, achieving the purpose of growing or extending the bone.
  • the advantage lies in that it is accompanied by a synchronous extension of soft tissue, so that the adaptability of the planting operation is further extended, but the disadvantage lies in: if it is pulled out from the outside of the mouth, it is easy to cause the skin to be infected, causing damage to the skin nerve tissue, leaving scars after operation, and the like.
  • the method has the advantages that the donor tissue needs to be small, a new form and function loss cannot be caused, accurate three-dimensional shaping can be carried out according to the morphology of the defect, and no antigen or antigen is little, but the defect is that: whether the biological function can exist in the body for a long time without denaturation, degeneration and the like still needs to be ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ further researched; and the tissue engineering bone still stays in the animal experiment stage.
  • Diba Tech's Solutions Diba Tech's bone graft substitute allows for large-scale, economical and sustainable production of macroscopically-porous bone graft substitutes with excellent biological performance.
  • Diba Tech's bone graft substitute is ideal for the repair of non-load bearing aseptic osseous defects of long bone and extremities as well as for the filling of spinal cages. Its mouldable and firm texture is especially suitable for the filling of bone defects that require longer-term support and volume stability.
  • Advantageous Effects of Invention [0013]
  • the customized blocked graft can provide a compatible and user-friendly product that can fit the anatomical site of the body. Firstly the design is unique and has a simple procedure to be made secondly compatibility and anatomical fitness can reduce the time of procedure and leads to excellent outcomes.
  • TCP patient-specific synthetic block graft
  • 3D printed blocke graft could be an advantageous and promising alternative to the use of other synthetic materials.
  • custom-made TCP graft has the potential not only to achieve predictable correction for jaw deformities but also to serve a merely cosmetic purpose in dental implants procedures.
  • the first step in the digital workflow is data collection using digital imaging, such as cone beam computed tomography (CBCT) and optical surface scanning, which includes intraoral scanning and extraoral model scanning.
  • digital imaging such as cone beam computed tomography (CBCT) and optical surface scanning, which includes intraoral scanning and extraoral model scanning.
  • Intraoral or extraoral optical surface scans allow the dentist to accurately represent both teeth and soft tissue as a digital Standard Tessellation Language (STL) file.
  • STL Digital Standard Tessellation Language
  • the STL file is transported to a virtual implant planning software, where the CAD process begins.
  • the STL file is registered and merged with the Digital Imaging and Communications in Medicine (DICOM or .dcm) files obtained from the CBCT imaging.
  • DICOM or .dcm Digital Imaging and Communications in Medicine
  • CAM processes as the final step involves subtractive or additive technology to fabricate and milling of block graft to the adapted shape of defect of mandibular and maxillary alveolar bones.
  • Industrial Applicability [0026] Reconstruction of the dentoalveolar complex is challenging because of the unique anatomy, the presence of vital structures and the diversity of defects. In jaw reconstruction and dental implant restoration of appearance and function is the primary goal.

Abstract

Reconstruction of the dentoalveolar complex is challenging because of the unique anatomy, the presence of vital structures and the diversity of defects. In jaw reconstruction and dental implant restoration of appearance and function is the primary goal. Customized TCP block graft is a synthetic graft that is compelled with patient bone in specific parts of the body like the jaws bone. Three-dimensional computerized tomogram and intraoral scanners can provide a pattern of specific bone in next step milling devices cuts block grafts and make them fit for the patient's specific parts of the body.

Description

^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ Descrition Titlelo ocfk Invreanftti wonith : A 3- mimetehnosio fonral c sutsetroemoliizteho sranthhetic Technical Field [0001] The invention relates to the technical field of biomedical engineering in synthetic customized bone graft. Background Art [0002] Implant for maxillofacial bone defect repair, and preparation method of implant filed in China whit 201910539243.5 application number. The invention discloses an implant for maxillofacial bone defect repair, and a preparation method of the implant. The implant structurally comprises a fixing unit and a porous structure part; the porous structure part is integrally connected with the fixing unit; the fixing unit comprises a screw hole and a first through hole; the fixing unit is matched with a healthy residual bone in shape; the porous structure part is located in the middle of the fixing unit and comprises a second through hole and an implant reserved socket; the porous structure part is filled in a maxillofacial disease bonearea or defect area; and the shape and size of the porous structure part are matched with the jaw anatomical structure of the maxillofacial disease bone area or defect area. According to the invention, personalized customization can be realized according to individual needs of patients; the implant is light in weight and low in material cost; meanwhile, the modulus of the implant is also reduced;therefore, the stress shielding effect caused by mismatching of the implant and the bone tissue modulus is avoided; the porous structure has the biological functions of promoting bone tissue ingrowth, vascularization and the like; and meanwhile, intraoperative bone grafting is carried out by reserving an implant alveolar socket, so that postoperative tooth implantation is facilitated. Summary of Invention [0003] Customized TCP block graft is a synthetic graft that is compelled with patient bone in specific parts of the body like the jaws bone. Three-dimensional computerized tomogram and intraoral scanners can provide a pattern of specific ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ bone in next step milling devices cuts block grafts and make them fit for the patient's specific parts of the body. Technical Problem [0004] The jaw bone is located in the face, the lower 2/3 region, which constitutes an important bone scaffold for the face profile of the jaw, which is one of the important tissues of the face of the human jaw. Maxillofacial defects caused by congenital development malformation, trauma, tumor or other diseases often disrupt the continuity and integrity of the jaw bone, causing the patient to chew, speech, etc. while affecting the patient's face. In the past, although jaw bone reconstruction can restore the continuity and integrity of the jaw bones to a great extent, the functions of post-operative chewing, language and the like and the face volume are difficult to completely recover to become the medical problem of the jaw. [0005] The method of jaw bone defect reconstruction mainly includes autologous bone grafting, bone replacement implant filling, traction osteotomy, bone tissue engineering, and the like. Wherein, the autologous bone graft is one method of jaw bone repair and reconstruction, and the method is a method for filling a defect area through bone tissue transplantation of a self-body health site, and fixing and promoting healing The method has the advantages that the bone membrane and the bone marrow are dual supply of blood, the infection resistance is strong, the survival rate is high, but the defect is that: Repair reconstruction after some malignant tumor surgery is not suitable for bone grafting methods, because radiotherapy and chemotherapy can cause the bone healing of a surgical site to be affected. [0006] The healthy bone taken from some other healthy part of the body will cause a certain damage to the original part.For some special populations such as athletes or bodies, there is no fit for such surgery; and autologous bone grafting is difficult to fully recover the patient's face tolerance requirements. Bone replacement implant filling is another repair method commonly used for maxillofacial surgery. [0007] Currently, currently available bone grafting substitute materials have a wide variety and different characteristics, wherein the main polymer synthetic material ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ such as polymethyl methacrylate, high-density polyethylene, polysulfone, and inorganic materials such as hydroxyapatite, calcium sulfate complex, calcium aluminum ceramic, etc.The present invention has the advantages that: the modulus and mechanical properties of the traditional substitute are difficult to be compatible with the bone tissue, and the phenomenon of "stress shielding effect" or insufficient force bearing due to mismatch of the implant and the bone tissue modulus is often avoided. Most of the implants at the present stage are standard size substitutes, which are difficult to accurately match the shape and size of the defect site; and the implant after implantation, and if the implant needs to be planted in the later stage, the implant will be extremely difficult. [0008] Traction osteotomy is by pulling the device, enabling the cut bone tissue to obtain a slow and stable continuous traction and tension, activating the proliferation function of the cell, thereby facilitating the generation of new bone between the truncated bones, achieving the purpose of growing or extending the bone.The advantage lies in that it is accompanied by a synchronous extension of soft tissue, so that the adaptability of the planting operation is further extended, but the disadvantage lies in: if it is pulled out from the outside of the mouth, it is easy to cause the skin to be infected, causing damage to the skin nerve tissue, leaving scars after operation, and the like. [0009] Traction is present in the patient, a foreign object is felt, and the daily life of the patient is affected; traction generated in the process of pulling the bone into the bone may cause damage to the alveolar nerve and the temporomandibular joint; and the current tractor specification model cannot be adaptively treated for the individual of the patient.Bone tissue engineering is the use of mechanical or chemical methods to separate them into a single cell suspension by tissue taken in vivo and in vitro culture in a simulated environment and then to tissue with a certain spatial structure to form tissues and organs with a certain function. The method has the advantages that the donor tissue needs to be small, a new form and function loss cannot be caused, accurate three-dimensional shaping can be carried out according to the morphology of the defect, and no antigen or antigen is little, but the defect is that: whether the biological function can exist in the body for a long time without denaturation, degeneration and the like still needs to be ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ further researched; and the tissue engineering bone still stays in the animal experiment stage. [0010] In summary, although a method for repairing a jaw surface at the present stage can repair the jaw surface from each aspect, there is a defect such as that the source of the autologous bone material is limited, antigen antibody rejection exists in the allogeneic material, other material modulus and mechanics are difficult to take into consideration, and meanwhile, problems such as implantation weight, shape size mismatch and the like are solved, so that the maxillofacial repair method still needs to be further refined, so as to overcome the deficiencies of the prior art Solution to Problem [0011] Diba Tech's Solutions: Diba Tech's bone graft substitute allows for large-scale, economical and sustainable production of macroscopically-porous bone graft substitutes with excellent biological performance. Diba Tech's bone graft substitute is ideal for the repair of non-load bearing aseptic osseous defects of long bone and extremities as well as for the filling of spinal cages. Its mouldable and firm texture is especially suitable for the filling of bone defects that require longer-term support and volume stability. [0012] Advantageous Effects of Invention [0013] The customized blocked graft can provide a compatible and user-friendly product that can fit the anatomical site of the body. Firstly the design is unique and has a simple procedure to be made secondly compatibility and anatomical fitness can reduce the time of procedure and leads to excellent outcomes. Brief Description of Drawings [0014] [Fig.1] The fellow chart of the method Description of Embodiments [0015] Autografts are the gold standard treatment, but they have several disadvantages, which has led to research into synthetic materials. The ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ development of CAD/CAM systems allows for precise preoperative planning and design of patient-specific synthetic bone grafts (TCP). [0016] In this process, two dimensional DICOM files were converted into 3- dimensional stereolithography files (STL) and the custom made block graft was designed using 3- dimensional software. [0017] The mandible and maxilla were printed as an STL model in resin for compatibility. The customized synthetic block graft was then printed using a laser sintering 3-dimensional printer. [0018] In this method patient-specific synthetic block graft (TCP) contributed considerably to improvement in the accuracy and reliability of oral rehabilitation, rapidly becoming an irreplaceable part of the surgical armamentarium. [0019] 3D printed blocke graft could be an advantageous and promising alternative to the use of other synthetic materials. [0020] Moreover, custom-made TCP graft has the potential not only to achieve predictable correction for jaw deformities but also to serve a merely cosmetic purpose in dental implants procedures. [0021] The first step in the digital workflow is data collection using digital imaging, such as cone beam computed tomography (CBCT) and optical surface scanning, which includes intraoral scanning and extraoral model scanning. [0022] Intraoral or extraoral optical surface scans allow the dentist to accurately represent both teeth and soft tissue as a digital Standard Tessellation Language (STL) file. The STL file is transported to a virtual implant planning software, where the CAD process begins. [0023] The STL file is registered and merged with the Digital Imaging and Communications in Medicine (DICOM or .dcm) files obtained from the CBCT imaging. [0024] Next, defect and graft site planned according to appropriate anatomical and Prosthetic principles. Additionally, the same software can design the synthetic block graft (TCP). ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ [0025] The use of CAM processes as the final step involves subtractive or additive technology to fabricate and milling of block graft to the adapted shape of defect of mandibular and maxillary alveolar bones. Industrial Applicability [0026] Reconstruction of the dentoalveolar complex is challenging because of the unique anatomy, the presence of vital structures and the diversity of defects. In jaw reconstruction and dental implant restoration of appearance and function is the primary goal.

Claims

obtaining radiographic data with cone-beam CT scan viewing surface scan with an intraoral scanner merging radiographic data with surface scans transfer all data to the milling machine milling the TCP block graft and converting it to adaptable customized anatomical bone graft Fig 1
PCT/IB2022/057549 2022-08-12 2022-08-12 A method for customized synthetic block graft with 3-dimensional stereolithography WO2024033692A1 (en)

Priority Applications (1)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5452407A (en) * 1992-06-10 1995-09-19 Amei Technologies Inc. Method for representing a patient's treatment site as data for use with a CAD or CAM device
WO2002085246A2 (en) * 2001-04-19 2002-10-31 Case Western Reserve University Fabrication of a polymeric prosthetic implant
US20200167514A1 (en) * 2013-08-20 2020-05-28 Arthur Greyf Method For 3-D Printing A Custom Bone Graft

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5452407A (en) * 1992-06-10 1995-09-19 Amei Technologies Inc. Method for representing a patient's treatment site as data for use with a CAD or CAM device
WO2002085246A2 (en) * 2001-04-19 2002-10-31 Case Western Reserve University Fabrication of a polymeric prosthetic implant
US20200167514A1 (en) * 2013-08-20 2020-05-28 Arthur Greyf Method For 3-D Printing A Custom Bone Graft

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