WO2024032686A1

WO2024032686A1 - Medicament delivery device with anti-needling function

Info

Publication number: WO2024032686A1
Application number: PCT/CN2023/112122
Authority: WO
Inventors: 杜天虎
Original assignee: 泰尔茂医疗产品(杭州)有限公司
Priority date: 2022-08-10
Filing date: 2023-08-10
Publication date: 2024-02-15
Also published as: CN219050059U

Abstract

The present invention provides a medicament delivery device with an anti-needling function, comprising: a medicine cylinder, provided with a proximal end, a distal end, and a chamber located between the proximal end and the distal end and configured for accommodating a solid implantation medicament; a hollow needle, fixed to the proximal end of the medicine cylinder and in communication with the chamber; a push rod assembly, installed at the distal end of the medicine cylinder and configured for pushing the solid implantation medicament in the chamber to enter the hollow needle; and a sleeve, sleeving the medicine cylinder, the sleeve comprising an upper sleeve and a lower sleeve which are connected with each other. The medicine cylinder can slide in the sleeve, and a spring is arranged between the sleeve and the medicine cylinder. The upper sleeve is provided with a starting buckle configured for locking the medicine cylinder. The lower sleeve is provided with a limiting buckle configured for limiting the downward movement of the medicine cylinder relative to the sleeve so as to prevent the hollow needle from being exposed out of the sleeve. According to the medicament delivery device of the present invention, when the solid implantation medicament is implanted into the human body of a patient, it can be ensured that the hollow needle returns to the interior of the device, and the hollow needle is prevented from being accidentally pushed out of the device, thus effectively avoiding accidents such as needling injury.

Description

Drug delivery device with anti-needle function

This application claims priority to the Chinese patent application submitted to the China Patent Office on August 10, 2022, with application number 202222095575.9 and the invention title "Medicine Delivery Device with Anti-needlestick Function", the entire content of which is incorporated by reference in in this application.

Technical field

The invention relates to the technical field of medical devices, and in particular to a medicine delivery device with an anti-needle function.

Background technique

Needle injuries are a serious threat to public health and can lead to the spread of diseases, such as HIV or hepatitis, often requiring people to be quarantined for considerable periods of time. In addition, once a needlestick injury occurs, it may cause psychological and physical trauma to the person, followed by a high degree of damage and serious economic burden. Therefore, cross-infection caused by needlestick injuries is unacceptable.

Needle injuries occur throughout the entire life cycle of medical devices. The emphasis on the risk of needle injuries has made the public want various types of safety systems to minimize the possibility of needle injuries by recycling needles or covering needles after use.

When administering sustained-release pharmaceuticals to the human body, the general approach is to first use a hollow needle to establish a channel to accommodate the pharmaceuticals in the abdominal wall of the human body, and then transport the pharmaceuticals into the body. There may be cases where the pharmaceuticals cannot be accurately and completely entered into the target location in the body, or the injection You may be injured by needles during and after the procedure.

For example, an existing technical solution is to manually push a metal rod out from the inside of a hollow needle so that the top of the metal rod exposes the needle tip for a certain distance. This combination of mechanisms can only protect against axial punctures. It cannot protect against scratches caused by the exposed needle tip, and the surface of the top of the metal rod will also enter the patient's body during the drug implantation process, which will produce blood-borne contamination and may cause infection.

For another example, another technical solution is proposed by Chinese invention patent CN01805275.4 The automatic operating safety sheath system of the syringe uses a complex mechanism to push the shell of the injection device forward after the puncture is completed to cover the needle tip. However, if the user's fingers are not placed in the correct position, they will block the deformation of the housing buckle, which may cause the mechanism to fail to start.

Contents of the invention

In view of this, the object of the present invention is to provide a drug delivery device with an anti-needle function, which is used to implant linear solid drugs into the patient's body. The drug delivery device can effectively ensure that the injection is completed. The hollow needle retreats back into the device to prevent accidents such as needle stick injuries caused by accidentally pushing the hollow needle out of the device.

According to an embodiment of the present invention, a drug delivery device with anti-needle puncture function is provided, including: a drug cartridge having a proximal end, a distal end and a cavity between the proximal end and the distal end for containing a solid implanted drug a chamber; a hollow needle, fixed to the proximal end of the cartridge and communicated with the chamber; a push rod assembly, installed to the distal end of the cartridge, used to push the solid implant agent into the hollow needle in the chamber; and a sleeve The sleeve is sleeved on the cartridge. The sleeve includes an upper sleeve and a lower sleeve that are connected to each other. The cartridge can slide in the sleeve, and a spring is provided between the sleeve and the cartridge; wherein, the upper sleeve is provided with a To lock the activating buckle of the cartridge, when the push rod assembly pushes the solid implant medicine into the hollow needle, the push rod assembly pushes the activating buckle to release the cartridge, so that the cartridge drives the hollow needle relative to the spring under the action of the spring. The sleeve moves upward to inject the solid implanted medicine out of the hollow needle; wherein, the lower sleeve is provided with a limiting buckle for limiting the downward movement of the drug cartridge relative to the sleeve to prevent the hollow needle from exposing the sleeve.

Further, the push rod assembly includes a push rod seat and a push rod connected to the push rod seat. A limiting clip for limiting the movement of the push rod seat is provided between the push rod seat and the sleeve.

Further, the push rod seat is provided with a locking buckle for locking the cartridge to the push rod seat.

Further, the locking buckle has a locking buckle surface extending obliquely toward the central axis of the push rod seat.

Further, when the cartridge moves upward relative to the sleeve under the action of the spring, The cartridge first squeezes the locking buckle of the push rod seat outward, and then the locking buckle springs back to lock the cartridge to the push rod seat.

Further, the push rod base has a pushing part for pushing the starting buckle, the pushing part has an outer inclined surface, and the starting buckle has an inner inclined surface matching the outer inclined surface of the pushing part.

Further, the lower sleeve is also provided with a baffle for limiting the upward movement of the cartridge relative to the sleeve.

Further, a flange is provided on the outer periphery of the cartridge, and the flange can be locked between the baffle of the lower sleeve and the limiting buckle.

Further, the limiting buckle has a limiting buckling surface extending obliquely toward the central axis of the sleeve.

Further, the medicine delivery device further includes a sheath placed on the outside of the hollow needle.

Further, when the spring is fully released, the hollow needle is fully retracted into the sleeve.

In this article, “moving upward” refers to the movement of the cartridge within the sleeve toward the push rod assembly, and “moving downward” refers to the movement of the cartridge within the sleeve toward the hollow needle.

The drug delivery device according to the present invention is mainly used for infusion of long-acting and sustained-release solid preparations.

Compared with the prior art, the technical solutions of the embodiments of the present invention have at least the following advantages:

In the medicine delivery device according to the embodiment of the present invention, the upper sleeve is provided with an activation buckle for locking the medicine cartridge. When the push rod assembly pushes the solid implanted medicine into the hollow needle, the push rod assembly pushes the activation buckle to lock the medicine cartridge. The cartridge is released, so that the cartridge drives the hollow needle to move upward relative to the sleeve under the action of the spring, so as to inject the solid implant medicine out of the hollow needle. Embodiments of the present invention use hollow needles to establish a stable and reliable tunnel for accommodating solid implanted medicaments in the abdominal wall of the human body, and transport the solid implanted medicaments to the interior close to the needle tip of the hollow needle, ensuring that the medicaments can completely enter the target human body. position, then in The empty needle retreats into the device, while the solid implanted agent stays in the tunnel and is subsequently released. There is no risk of needle exposure during the entire process, and accidents such as needle stick injuries are avoided.

Moreover, the lower sleeve is provided with a limiting buckle for limiting the downward movement of the cartridge relative to the sleeve to prevent the hollow needle from being exposed from the sleeve, thus preventing the operator from accidentally pushing the push rod assembly and causing the hollow needle to be exposed from the sleeve. Accidents such as needle stick injuries may occur.

Further, the push rod assembly includes a push rod seat and a push rod connected to the push rod seat. A limiting clip for limiting the movement of the push rod seat is provided between the push rod seat and the sleeve. Before use, the movement of the push rod seat is limited by the limiting clip to prevent the solid implant agent from being pushed into the hollow needle due to accidental pushing of the push rod seat.

Further, the push rod seat is provided with a locking buckle for locking the cartridge to the push rod seat. The cartridge is locked to the push rod seat through the locking buckle, thereby realizing the interlocking of the cartridge and the push rod seat.

Furthermore, the lower sleeve is also provided with a baffle for limiting the upward movement of the cartridge relative to the sleeve. The outer periphery of the cartridge is provided with a flange, and the flange can be locked between the baffle of the lower sleeve and the limiting buckle. Through the cooperation of the baffle and the limit buckle, the movement of the cartridge is limited so that the cartridge can neither move upward nor downward, thus avoiding the accidental pushing of the hollow needle out of the device.

Description of drawings

Other features and advantages of the present invention will be better understood from the following detailed description of alternative embodiments in conjunction with the accompanying drawings, in which like reference numerals represent the same or similar parts, in which:

Figure 1 shows a schematic diagram of a medicament delivery device according to one embodiment of the present invention;

Figure 2 shows a schematic cross-sectional view of the medicament delivery device of the embodiment shown in Figure 1;

Figure 3 shows a schematic diagram of the use process of the medicine delivery device of the embodiment shown in Figure 1, in which the push rod assembly pushes the activation buckle to release the medicine cartridge;

Figure 4 shows a schematic diagram of the use process of the medicine delivery device of the embodiment shown in Figure 1, in which the medicine cartridge pushes the locking buckle outward under the action of the spring;

Figure 5 shows a schematic diagram of the use process of the medicine delivery device of the embodiment shown in Figure 1, in which the locking buckle rebounds to lock the cartridge to the push rod seat;

Figure 6 shows a schematic diagram of the use process of the medicine delivery device of the embodiment shown in Figure 1, in which the limiting buckle limits the downward movement of the medicine cartridge; and

Figure 7 shows a schematic view of the drug delivery device of the embodiment shown in Figure 1 after use, with the hollow needle withdrawn into the interior of the device.

Detailed ways

The implementation and use of the embodiments are discussed in detail below. It should be understood that the specific embodiments discussed are merely illustrative of specific ways to make and use the invention and do not limit the scope of the invention. When describing, the structural position of each component, such as up, down, top, bottom, etc., are not absolute but relative. These directional representations are appropriate when the components are arranged as shown in the figures, but will change when the position of the components in the figures is changed.

As shown in FIGS. 1 to 2 , the medicine delivery device 100 includes a medicine cartridge 10 , a hollow needle 20 , a push rod assembly 30 and a sleeve 40 . The cartridge 10 has a proximal end 11 , a distal end 12 and a chamber 13 located between the proximal end 11 and the distal end 12 for accommodating the solid implanted medicament 50 . The distal end 12 is provided with a cartridge plug 14 that closes the chamber 13 . . The hollow needle 20 is fixed to the proximal end 11 of the cartridge 10 and communicates with the chamber 13 . The hollow needle 20 has a needle tube 21 and a needle tip 22. The needle tube 21 is connected with the chamber 13. The needle tip 22 is used to penetrate, for example, the abdominal wall of a human body to establish a tunnel to accommodate the solid implanted medicine 50.

The push rod assembly 30 is mounted to the distal end 12 of the cartridge 10 for pushing the solid implanted medicament 50 into the hollow needle 20 within the chamber 13 . The push rod assembly 30 includes a push rod base 31 and a push rod 32 connected to the push rod base 31. A limiting clip 33 is provided between the push rod base 31 and the sleeve 40 for limiting the movement of the push rod base 31. Before use, the movement of the push rod base 31 is limited by the limiting clip 33 to prevent the solid implantation of medicine due to accidental pushing of the push rod base 31. 50 push into the hollow needle 20. One end of the push rod 32 is fixed to the center of the push rod seat 31 in a known manner, and the other end extends through the cartridge plug 14 into the chamber 13 of the cartridge 10 to facilitate pushing the solid implanted medicine 50 in the chamber 13 Move down inside.

Herein, “moving upward” refers to the movement of the cartridge 10 in the sleeve 40 toward the push rod assembly 30 , and “moving downward” refers to the movement of the cartridge 10 in the sleeve 40 toward the hollow needle 20 , that is, move away from the push rod assembly 30 .

The sleeve 40 is sleeved on the outside of the cartridge 10. The sleeve 40 includes an upper sleeve 41 and a lower sleeve 42. The inner diameter of the upper sleeve 41 is larger than the inner diameter of the lower sleeve 42. The upper sleeve 41 is used to accommodate the push rod assembly. The push rod seat 31 of 30 and the lower sleeve 42 are used to accommodate the cartridge 10. The upper sleeve 41 and the lower sleeve 42 can be two separate parts connected to each other in a known manner, or they can be integrally formed by, for example, injection molding. For example, two symmetrical grooves are provided on the outer circumference of the upper sleeve 41, and two symmetrical protrusions are provided on the outer circumference of the lower sleeve 42. By snapping the protrusions of the lower sleeve 42 into the corresponding recesses, In the groove, the upper sleeve 41 and the lower sleeve 42 are assembled. The cartridge 10 can slide upward and downward relative to the sleeve 40 in the sleeve 40. A spring 60 is provided between the upper sleeve 41 of the sleeve 40 and the cartridge 10. When the cartridge 10 is installed into the sleeve 40 , spring 60 is in a compressed state.

The upper sleeve 41 is provided with an activating buckle 411 for locking the cartridge 10. For example, the upper sleeve 41 is provided with two symmetrically arranged activating buckles 411. The activating buckles 411 can be, for example, elastic formed on the upper sleeve 41. In the form of arms or elastic sheets. When the push rod assembly 30 pushes the solid implant medicine 50 into the hollow needle 20, the push rod base 31 of the push rod assembly 30 pushes the activating buckle 411, and expands the activating buckle 411 outward to release the cartridge 10, so that The medicine cartridge 10 drives the hollow needle 20 to move upward relative to the sleeve 40 under the action of the spring 60 , so that the push rod 32 of the push rod assembly 30 pushes the solid implanted medicine 50 out of the hollow needle 20 . The lower sleeve 42 is provided with a limiting buckle 421 for limiting the downward movement of the cartridge 10 relative to the sleeve 40 to prevent the hollow needle 20 from exposing the sleeve 40 .

In some embodiments, the push rod base 31 is provided with a locking catch 311 for locking the cartridge 10 to the push rod base 31 . The locking buckle 311 has a central axis facing the push rod seat 31 The locking catch surface 3111 extends obliquely. For example, the push rod base 31 is provided with two symmetrically arranged locking buckles 311 , and the locking buckles 311 may be in the form of elastic arms or elastic sheets formed on the push rod base 31 . When the cartridge 10 moves upward relative to the sleeve 40 under the action of the spring 60, the cartridge 10 first squeezes the locking buckle 311 of the push rod seat 31 outward. When the cartridge 10 slides above the locking buckle 311, The locking buckle 311 rebounds to lock the cartridge 10 to the push rod seat 31, thereby realizing the interlocking of the cartridge 10 and the push rod seat 31.

As shown in FIG. 3 to FIG. 5 , in some embodiments, the push rod base 31 has a pushing part 312 for pushing the activating buckle 411 , the pushing part 312 has an outer inclined surface 3121 , and the activating buckle 411 has a pushing part The outer inclined surface 3121 of 312 matches the inner inclined surface 4111, so that the pushing part 312 pushes the activation buckle 411. When the push rod base 31 moves downward, the outer inclined surface 3121 of the pushing part 312 slides along the inner inclined surface 4111 of the activating buckle 411, gradually opening the activating buckle 411 outward, thereby releasing the cartridge 10.

As shown in FIG. 6 , in some embodiments, the lower sleeve 42 is also provided with a baffle 422 for limiting the upward movement of the cartridge 10 relative to the sleeve 40 . A flange 15 is provided on the outer periphery of the cartridge 10 , and the flange 15 can be locked between the baffle 422 of the lower sleeve 42 and the limiting buckle 421 of the lower sleeve 42 .

In some embodiments, the limiting buckle 421 has a limiting buckling surface 4211 extending obliquely toward the axis of the sleeve 40 . When the cartridge 10 moves upward in the sleeve 40, the flange 15 of the cartridge 10 moves upward along the limiting buckle surface 4211, thereby pushing the limiting buckle 421 outward. When the buckle 421 is above, the limiting buckle 421 rebounds to lock the cartridge 10 between the baffle 422 of the lower sleeve 42 and the limiting buckle 421 of the lower sleeve 42 .

In some embodiments, the drug delivery device 100 further includes a sheath 70 sheathed on the outside of the hollow needle 20 . Before use, the sheath 70 is placed on the outside of the hollow needle 20 to prevent the hollow needle from stabbing the patient or medical staff. The sheath 70 is removed during use. In some embodiments, when spring 60 is fully released, hollow needle 20 is fully retracted into sleeve 40. For example, when the hollow needle 20 is fully retracted into the lower sleeve 42 of the sleeve 40, the center The distance between the end of the empty needle 20 and the end of the lower sleeve 42 of the sleeve 40 is 2 mm to 10 mm.

As shown in Figure 3, when the user injects, first remove the limit clip 33 and the sheath 70, then puncture the patient's skin through the needle tip 22 of the hollow needle 20, pierce the hollow needle 20 under the skin, and push the push rod assembly 30 The push rod seat 31 drives the push rod 32 to move downward, and the push rod 32 transports the solid implant medicine 50 into the needle tube 21 of the hollow needle 20. As the push rod base 31 is pressed, the solid implanted medicine 50 is pushed to a position close to the needle tip 22 of the hollow needle 20. At the same time, the activation buckle 411 of the upper sleeve 41 of the sleeve 40 is opened by the push rod base 31. To unlock the cartridge 10, the cartridge 10 is pushed upward by relying on the elastic force of the spring 60 to restore its deformation.

As shown in Figures 4 and 5, the cartridge 10 slides axially upward along the push rod 32. The cartridge 10 pushes against the locking buckle 311 of the push rod seat 31 and continues to slide. Then the locking buckle 311 resumes its deformation, thereby achieving Interlocking of cartridge 10 and push rod seat 31. At this time, the solid implanted medicine 50 is restricted by the push rod 32 and does not retreat, and the hollow needle 20 retreats into the sleeve 40 along with the cartridge 10. At this point, the solid implanted medicine 50 is exposed from the needle tube 21 of the hollow needle 20 and enters the patient. subcutaneous.

As shown in Figure 6, as the solid implanted medicine 50 enters the patient's subcutaneous, the injection process has been completed. At this time, the restriction on the tail of the push rod seat 31 is released, and the spring 60 will continue to recover its deformation, thereby continuing to push the cartridge 10 Push back, the cartridge 10 continues to move upward along the axial direction of the push rod 32, opens the limit buckle 421 of the lower sleeve 42 of the sleeve 40, and hits the baffle 422 of the lower sleeve 42 of the sleeve 40. , the limit buckle 421 rebounds to block the downward movement of the cartridge 10, and at the same time the baffle 422 blocks the upward movement of the cartridge 10, so that the cartridge 10 can neither move upward nor downward, thereby avoiding the accidental movement of the hollow needle. Push out the device. At this time, the needle tip 22 of the hollow needle 20 is completely retracted into the lower sleeve 42 of the sleeve 40 .

In the medicine delivery device according to the embodiment of the present invention, the upper sleeve is provided with an activation buckle for locking the medicine cartridge. When the push rod assembly pushes the solid implanted medicine into the hollow needle, the push rod assembly pushes the activation buckle to lock the medicine cartridge. Release the cartridge so that it carries the cartridge under the action of the spring The hollow needle moves upward relative to the sleeve to inject the solid implant agent out of the hollow needle. Embodiments of the present invention use hollow needles to establish a stable and reliable tunnel for accommodating solid implanted medicaments in the abdominal wall of the human body, and transport the solid implanted medicaments to the interior close to the needle tip of the hollow needle, ensuring that the medicaments can completely enter the target human body. position, and then the hollow needle retreats into the interior of the device, while the solid implant agent stays in the tunnel. There is no risk of needle exposure during the entire process, and accidents such as needle stick injuries are avoided.

The technical content and technical features of the present invention have been disclosed above. However, it can be understood that under the creative thinking of the present invention, those skilled in the art can make various changes and improvements to the above disclosed concepts, but they all fall within the protection scope of the present invention. . The description of the above embodiments is illustrative rather than restrictive, and the scope of protection of the present invention is determined by the claims.

Claims

A medicine delivery device with anti-needle puncture function, which is characterized in that it includes:

a cartridge having a proximal end, a distal end, and a chamber located between the proximal end and the distal end for containing a solid implanted medicament;

a hollow needle fixed to the proximal end of the cartridge and communicated with the chamber;

a push rod assembly mounted to the distal end of the cartridge for pushing the solid implanted agent into the hollow needle within the chamber; and

Sleeve, set on the cartridge, the sleeve includes an upper sleeve and a lower sleeve connected to each other, the cartridge can slide within the sleeve, the sleeve and the cartridge There are springs in between;

Wherein, the upper sleeve is provided with an activation buckle for locking the medicine cartridge. When the push rod assembly pushes the solid implant medicine into the hollow needle, the push rod assembly pushes the Activate the buckle to release the cartridge, so that the cartridge drives the hollow needle to move upward relative to the sleeve under the action of the spring, so as to inject the solid implant medicine out of the hollow needle ;

Wherein, the lower sleeve is provided with a limiting buckle for restricting the downward movement of the cartridge relative to the sleeve to prevent the hollow needle from exposing the sleeve.
The medicine delivery device with acupuncture prevention function according to claim 1, wherein the push rod assembly includes a push rod base and a push rod connected to the push rod base, and the push rod base and the push rod base are A limiting clip is provided between the sleeves for limiting the movement of the push rod seat.
The medicine delivery device with anti-needlestick function according to claim 2, wherein the push rod seat is provided with a locking buckle for locking the medicine cartridge to the push rod seat.
The medicine delivery device with anti-needle puncture function according to claim 3, characterized in that the locking buckle has an inclination toward the central axis of the push rod seat. Extended locking snap surface.
The medicine delivery device with anti-needle puncture function according to claim 3, characterized in that when the medicine cartridge moves upward relative to the sleeve under the action of the spring, the medicine cartridge first moves outward The locking catch of the push rod seat is squeezed and the locking catch springs back to lock the cartridge to the push rod seat.
The medicine delivery device with anti-needle puncture function according to claim 2, wherein the push rod base has a pushing part for pushing the activation buckle, and the pushing part has an outer inclined surface, so The activation buckle has an inner inclined surface matching the outer inclined surface of the pushing part.
The medicine delivery device with anti-needle puncture function according to any one of claims 1 to 6, characterized in that the lower sleeve is also provided with a device for limiting the upward movement of the medicine cartridge relative to the sleeve. baffle.
The medicine delivery device with anti-needle puncture function according to claim 7, characterized in that a flange is provided on the outer periphery of the medicine cartridge, and the flange can be locked on the baffle of the lower sleeve. and the limit buckle.
The medicine delivery device with anti-needle puncture function according to any one of claims 1 to 6, characterized in that the limiting buckle has a limiting buckle extending obliquely toward the central axis of the sleeve. surface.
The medicine delivery device with anti-needle puncture function according to any one of claims 1 to 6, characterized in that the medicine delivery device further includes a sheath placed on the outside of the hollow needle.
The medicine delivery device with anti-needle puncture function according to any one of claims 1 to 6, characterized in that when the spring is completely released, the hollow needle is completely retracted into the sleeve.