WO2024028628A1 - Cathéter de collecte de sang ayant une capacité d'implantation à long terme - Google Patents
Cathéter de collecte de sang ayant une capacité d'implantation à long terme Download PDFInfo
- Publication number
- WO2024028628A1 WO2024028628A1 PCT/IB2022/057102 IB2022057102W WO2024028628A1 WO 2024028628 A1 WO2024028628 A1 WO 2024028628A1 IB 2022057102 W IB2022057102 W IB 2022057102W WO 2024028628 A1 WO2024028628 A1 WO 2024028628A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- catheter
- needle
- blood
- cap
- tube
- Prior art date
Links
- 239000008280 blood Substances 0.000 title claims abstract description 49
- 210000004369 blood Anatomy 0.000 title claims abstract description 49
- 230000007774 longterm Effects 0.000 title description 11
- 238000002513 implantation Methods 0.000 title description 4
- 210000003462 vein Anatomy 0.000 claims abstract description 23
- 230000000774 hypoallergenic effect Effects 0.000 claims abstract description 4
- 230000002269 spontaneous effect Effects 0.000 claims abstract description 3
- 238000003780 insertion Methods 0.000 claims description 8
- 230000037431 insertion Effects 0.000 claims description 8
- 244000005700 microbiome Species 0.000 claims description 7
- 238000010241 blood sampling Methods 0.000 claims description 6
- 230000003266 anti-allergic effect Effects 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 14
- 238000002347 injection Methods 0.000 description 12
- 239000007924 injection Substances 0.000 description 12
- 230000002093 peripheral effect Effects 0.000 description 10
- 210000004204 blood vessel Anatomy 0.000 description 9
- 230000002792 vascular Effects 0.000 description 8
- 208000014674 injury Diseases 0.000 description 7
- 238000009534 blood test Methods 0.000 description 6
- 230000008733 trauma Effects 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 5
- 230000002354 daily effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 208000034656 Contusions Diseases 0.000 description 3
- 208000005189 Embolism Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000010253 intravenous injection Methods 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 231100000241 scar Toxicity 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 208000032544 Cicatrix Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000037387 scars Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 208000034526 bruise Diseases 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000037325 pain tolerance Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/06—Body-piercing guide needles or the like
- A61M25/0606—"Over-the-needle" catheter assemblies, e.g. I.V. catheters
Definitions
- Is an intravascular catheter consisting of a hypoallergenic plastic tube section in different sizes that is inserted into a vein.
- a body that is placed on the surface of the body and has a wing-like part that is fixed on the skin of the entry point. The end of this cover body is fixed by twisting.
- Inside the flexible tube there is an elastic layer with a closed head, which prevents the spontaneous exit of blood from this catheter.
- Inside the flexible tube there is also a removable needle that helps us enter the vein, and the end of this needle is removed from the end of the body by a plastic structure. The sharp tip of this needle is outside the closed end of the elastic layer and finally exits from the external side of the catheter.
- This needle does not remain in the catheter during the time of connecting the catheter to the patient and is removed. And finally, it has a plastic cap for the end of the catheter and a cap for the needle
- An implantable catheter comprises a flexible elongated catheter body having an inflatable balloon positioned near its distal end. At least one distal delivery port is located distal of the balloon and at least one proximal delivery port is located proximal of the balloon.
- the balloon and the distal and proximal delivery ports are connected in fluid communication with individual lumens.
- the lumen connected to the balloon is connected to a balloon inflation port at the proximal end of the catheter.
- the lumens connected to the distal and proximal delivery ports are connected to distal and proximal injection ports.
- the balloon inflation port and the distal and proximal injection ports are all built into an integrated port assembly adapted for implantation under the skin of a medical patient.
- the distal end of the catheter is inserted and fed into a passageway such as a blood vessel until the balloon and delivery ports lie within a region of interest.
- the port assembly is then implanted under the patient's skin.
- the balloon can be inflated to occlude the flow of fluid through the passageway, and therapeutic agents can be delivered either distal or proximal of the balloon by injection into the appropriate injection port. It is believed that the catheter is particularly suited to the delivery of hepatocytes and an anticoagulant during a course of cell therapy directed to a patient's liver.
- a check valve for placement near the distal end of a catheter.
- a continuously smooth outer surface for the catheter with a check valve system assures that there is no propensity for a blood clot to form in cracks on the system's outer surface.
- the check valve is formed from a low durometer, highly elastic, elastomer cylindrical tube that is shrunk into a cylindrical groove that would typically be located near the catheter's distal end.
- pressurized fluid is injected through the catheter, the cylinder that is placed over one or more holes in the cylindrical groove in the catheter is forced to expand radially outward which allows the fluid to be injected into the blood vessel.
- the elastomer tube retracts to its normal position which position tightly covers the holes thereby preventing any blood from entering the catheter.
- a valve assembly includes an elongated valve body, an elastomeric sheath laterally enclosing the outside surface of the valve body with the sheath being sealed to the valve body at its ends spaced apart in the elongated direction.
- An inlet channel extends in the elongated direction from one end of the valve body for receiving a fluid from a container, such as a flexible container.
- An outlet channel is located at the opposite end of the valve body extending in the elongated direction for discharging the fluid received in the inlet channel.
- At least one port extends outwardly from the inlet channel to the outside surface of the valve body so that the fluid can flow between the outside surface and the elastomeric sheath causing the sheath to expand.
- the fluid between the outside surface of the valve body and the sheath flows to at least one other port in the valve body directed inwardly to the outlet channel so that the fluid can be discharged.
- the sheath prevents back flow from the outlet channel into the container.
- a subcutaneous delivery device assembly and method are provided.
- the assembly includes a subcutaneous delivery device comprising a catheter, a self-sealing input port at the first end of the catheter, an internal magnet adjacent to the self-sealing port, and a valve at the second end of the catheter.
- the assembly further includes a corresponding external locator which is adapted to be magnetically located adjacent to the internal magnet and separator therefrom by a thin layer of human tissue. The assembly can be used to locate and stabilize a syringe needle during injection.
- An improved valve assembly is provided for the distal end of a catheter, and particularly a central venous catheter for controlling fluid passage from the catheter to the blood flow passage in which it is inserted, and flow in the opposite direction.
- a relatively thin sheath wall covers the distal fluid opening of the catheter, and includes a slit for responding rapidly to pressure differentials on either side of the slit opening to allow fluid passage, as required.
- the distal end of the catheter, and the side walls thereof adjacent the end are covered by a thin sheath which serves to impart a small degree of thickness or "body" to the end of the catheter except at the opening thereof. More importantly, with the arrangement here the integrity of the catheter wall is far less compromised.
- the valve catheter comprises a flexible material, cylindrical tube having a U-shaped outer wall extending longitudinally about the distal portion thereof.
- a flat-surfaced valve is positioned in the recess along the U-shaped distal portion and attached to the outer wall.
- the valve is formed by inserting a flat-surfaced rod in the U-shaped portion of the tube to stretch the outer wall.
- a flat-surfaced layer of flexible material is applied over the flat-surfaced rod to the stretched outer wall.
- the flexible material layer is cured and a longitudinal fluid aperture formed therein with the rod remaining in the passage of the U-shaped portion.
- the rod is then removed and a plug inserted into the passage to close the distal end of the catheter.
- the stretched outer wall of the U-shaped portion compresses the fluid aperture to a predetermined closed position to prevent fluid leakage therethrough.
- This invention is related to the knowledge of medical science in the blood collection basin, which can be placed in place for a long time.
- the invented catheter acts as a long-term way to access the peripheral vessels, and there is no need to traumatize the patient for daily blood draws.
- the blocking layers of pipes act to significantly reduce the entry of microorganisms.
- the designed catheter consists of 5 components, the elastic layer (3) is fixed inside the flexible tube (2) and the needle component (4) is placed inside this layer (3) so that the end of this component (4) It protrudes from the end of the main body (2) and is fixed there with a certain structure (with a wider edge and outer sides that are fully described in the claim).
- This catheter has two caps, one (1) is connected to the flexible tube and the other (5) is connected to the end of the body. Although the main function of this catheter is to draw blood, this catheter can also be used for people who need frequent intravascular injections.
- this catheter In the way that this catheter is installed as an access to the vessels and for each injection we use a needle according to its size. We insert the needle into the catheter and perform vascular injection through it.
- Angioket peripheral vascular catheter
- This catheter is a small flexible catheter that is placed inside the patient's peripheral vessels. This catheter is only used for intravenous injection and fluid therapy. This catheter is used for vascular access before surgeries, in emergency rooms, inpatient departments, etc. Anjucts are usually placed on the veins of the hand and arm. This catheter cannot be used for blood collection because with the fluid therapy and drug therapy that is done through this catheter, the characteristics of the blood fluid around this catheter will change and it will make the response of blood tests difficult, as well as the opening of the end of the catheter. Intravascularization of this catheter causes blood to enter its tubes and the growth of micro-organisms after 48 to 72 hours. Infection, phlebitis, blood vessel rupture, embolism, hematoma, etc. can be among the side effects of injectables.
- CVline Central Venous Catheter: This catheter is used to open the central venous line for long-term hospitalized patients, for long-term fluid transfer, drug therapy, blood sampling, nutritional support, transfusions and products.
- CV line can remain inside the central vein for a month, and this increases the risk of infection and can cause intravascular embolism. Also, the insertion of this catheter is not recommended except in necessary cases due to its invasive process. (due to the prohibition of unnecessary invasive processes in hospitals)
- Permiket and Shaldon these two catheters are implanted for long-term vascular access for patients who need permanent and long-term access to central vessels (such as dialysis patients).
- This catheter is placed inside the central vein (jugular, femoral, etc.) and is used for dialysis.
- This catheter can also be used for blood sampling, which increases the possibility of infection and embolism, due to the access of this catheter to the central vessels. Due to the aggressiveness of the catheterization process, this catheter is not used unless necessary.
- Syringes Today, in the country's hospitals, syringes are used for blood sampling, which, despite its benefits in long-term hospitalizations, can turn blood sampling into a much more painful process than expected and cause numerous scars on the skin and blood vessels, which causes pain and sometimes limits the movement of the organs and will prolong the healing process.
- the catheter invented by this side acts as a long-term way to access the peripheral vessels, and for daily blood draws, there is no need to introduce any trauma to the patient. Also, the blocking layers of pipes act to significantly reduce the entry of microorganisms.
- the designed device is a peripheral vascular catheter made of 5 components.
- the designed catheter consists of 5 components, the elastic layer (3) is fixed inside the flexible tube (2) and the needle component (4) is placed inside this layer (3) so that the end of this component (4) is outside the end of the main body (2) and it is fixed there with a certain structure (with a wider edge and outer edges that are fully described in the claim).
- This catheter has two caps, one (1) is connected to the flexible tube and the other (5) is connected to the end of the body.
- the nurse/embedding person after finding a healthy, suitable and smooth vein using the usual methods (use of garou, etc.) after periodically disinfecting the catheter insertion site with alcohol, he first removes the tube cap (1) at this time, the tube (2) and the tip of the needle (4) will be clear from the end of the tube. At this time, it is done exactly according to the angioket embedding method.
- This catheter is made of hypoallergenic materials and will be sterilized like all intravascular catheters.
- the different sizes of this catheter allow us to choose the correct size instead of each size in different cases.
- this catheter (2) The body fins of this catheter (2) are well fixed on the body with CM or straw adhesives or any of the adhesives available in the sections and it keeps the main body fixed on the body and thus the flexible tube inside the body.
- the flexible tube and the main body are located continuously and there is no possibility of separating these two components.
- This structure is designed to prevent the entry of microorganisms into the space inside the catheter.
- an elastic layer (3) that covers the open end of the tube and thus separates the space inside the body from the space inside this catheter. Also, the elastic structure of this layer allows us to pass through it several times without leaving a hole in this layer in order to draw blood. Because after removing the needle from it, the surrounding tissue immediately fills the hole and as a result does not allow the blood to enter the catheter and thus leave the body.
- a syringe with the appropriate needle head number can be used or insert the appropriate needle and device from that part and move along the length of the catheter to the end of the needle.
- the appropriate needle tip should have the same length and diameter as the catheter itself (4).
- the needle protrudes approximately half a centimeter from the closed end of the catheter, which is covered by the elastic layer and is located inside the body. This protrusion allows us to access the peripheral vessels without causing re-trauma.
- This catheter actually works like an impenetrable tunnel into the blood vessels. For each blood draw, we just need to insert the needle into the space inside the catheter and draw blood from the inside of the blood vessels.
- the above system does not require heparinization due to the absence of blood entering the thin tubes of the catheter and the absence of the possibility of catheter coagulation, which will help in preventing problems in blood tests.
- the presence of heparin liquid in the tubes of catheters such as Permicet means that we have to throw away some blood to collect blood from people with Permicet from their permicet site, Therefore, as a result of not heparinizing the designed catheter, it means that people with anemia or people who have frequent blood tests will lose less blood.
- the elastic layers designed inside this catheter cause far fewer microorganisms to enter and thus reduce the possibility of infection through this catheter.
- the elastic property of the layer covering the inner end of the catheter prevents blood from entering the catheter and thus prevents the creation of a suitable environment for the growth of pathogenic agents.
- This invention prevents needles and syringes from entering the patients' vessels several times a day. Once this catheter is inserted, it will be usable for at least 72 hours.
- the elastic structures embedded in this catheter help to control the infection much better than the previous inventions.
- Elastic structures also prevent unwanted blood from this catheter.
- This catheter is much easier than other catheters with the ability to be inserted for a long time and does not require the transfer of the patient to the operating room.
- This catheter is disposable
- This catheter does not need to be heparinized
- this catheter is not heparinized, it reduces the possibility of laboratory errors (compared to existing permanent catheters).
- This catheter can stay in the fixed vein for a longer period of time because due to the absence of liquid etc. in the space inside this catheter, the possibility of micro-organisms entering and growing inside this catheter will be far less than other catheters.
- this catheter can also be used for people who need frequent intravenous injections.
- this catheter is installed as an access to the vessels and for each injection we use a needle according to its size. We insert the needle into the catheter and perform vascular injection through it.
- Flexible catheter which is a thin tube and is inserted into the vein.
- the main body of the catheter which is connected to the end of the flexible tube and has two wing-like structures, is placed on the body.
- the needle part that is placed inside the elastic cover and helps us to enter the skin and blood vessels. This part will be removed after the catheter is fixed. 5.
- the end cap is to prevent blood from escaping
- Catheter needle cap to protect the needle and flexible catheter 2.
- Flexible catheter which is a thin tube and is inserted into the vein.
- the main body of the catheter which is connected to the end of the flexible tube and has two wing-like structures, is placed on the body.
- Elastic cover with a closed end that is placed inside the flexible tube.
- the needle part that is placed inside the elastic cover and helps us to enter the skin and blood vessels. This part will be removed after the catheter is fixed. 5.
- the end cap is to prevent blood from escaping
- the nurse/implanter after finding a healthy, suitable and smooth vein using the usual methods (using a tourniquet and finding a suitable vein) and after periodically disinfecting the catheter insertion site with alcohol, he first removes the tube cap (1) at this time, the tube (2) and the tip of the needle (4) will be clear from the end of the tube. At this time, it is done exactly according to the angioket embedding method. This means that the flexible tube (2) and the needle (4) are directed into the body towards the specified vein. After the blood enters the needle (4), we take the needle out a little so that it enters the catheter through the elastic space, then we turn the body forward until the tube is completely inside the body. Then we fix the body completely on the body with glue.
- This catheter can also be used for people who need frequent intravenous injections.
- this catheter is installed as an access to the vessels and for each injection we use a needle according to its size. We insert the needle into the catheter and perform vascular injection through it.
- This invention is related to the field of medical sciences, and as a result, it is industrially related to the medical equipment industry. This invention is used in medical centers, hospitals, in non-patients who need frequent blood tests.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Cathéter intravasculaire constitué d'une section de tube en plastique hypoallergénique de différentes tailles qui est inséré dans une veine. Un corps est placé sur la surface du corps et comporte une partie en forme d'aile qui est fixée sur la peau du point d'entrée. L'extrémité de ce corps de couvercle est fixée par torsion. À l'intérieur du tube flexible se trouve une couche élastique avec une tête fermée, qui empêche la sortie spontanée du sang de ce cathéter. À l'intérieur du tube flexible se trouve également une aiguille amovible qui aide à entrer dans la veine, et l'extrémité de cette aiguille est retirée de l'extrémité du corps par une structure en plastique. Le bout pointu de cette aiguille se trouve à l'extérieur de l'extrémité fermée de la couche élastique et sort finalement du côté externe du cathéter.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2022/057102 WO2024028628A1 (fr) | 2022-07-30 | 2022-07-30 | Cathéter de collecte de sang ayant une capacité d'implantation à long terme |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2022/057102 WO2024028628A1 (fr) | 2022-07-30 | 2022-07-30 | Cathéter de collecte de sang ayant une capacité d'implantation à long terme |
Publications (1)
Publication Number | Publication Date |
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WO2024028628A1 true WO2024028628A1 (fr) | 2024-02-08 |
Family
ID=89848584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/IB2022/057102 WO2024028628A1 (fr) | 2022-07-30 | 2022-07-30 | Cathéter de collecte de sang ayant une capacité d'implantation à long terme |
Country Status (1)
Country | Link |
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WO (1) | WO2024028628A1 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060258957A1 (en) * | 2005-05-10 | 2006-11-16 | Deleon Luis | Blood drawing system |
US20180318557A1 (en) * | 2017-05-04 | 2018-11-08 | Becton, Dickinson And Company | Intravenous catheter systems and methods |
WO2022032242A1 (fr) * | 2020-08-07 | 2022-02-10 | Avia Vascular, Llc | Dispositifs, systèmes et procédés de prélèvement sanguin |
-
2022
- 2022-07-30 WO PCT/IB2022/057102 patent/WO2024028628A1/fr unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060258957A1 (en) * | 2005-05-10 | 2006-11-16 | Deleon Luis | Blood drawing system |
US20180318557A1 (en) * | 2017-05-04 | 2018-11-08 | Becton, Dickinson And Company | Intravenous catheter systems and methods |
WO2022032242A1 (fr) * | 2020-08-07 | 2022-02-10 | Avia Vascular, Llc | Dispositifs, systèmes et procédés de prélèvement sanguin |
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