WO2024028058A1 - Composition de nettoyage liquide - Google Patents
Composition de nettoyage liquide Download PDFInfo
- Publication number
- WO2024028058A1 WO2024028058A1 PCT/EP2023/069379 EP2023069379W WO2024028058A1 WO 2024028058 A1 WO2024028058 A1 WO 2024028058A1 EP 2023069379 W EP2023069379 W EP 2023069379W WO 2024028058 A1 WO2024028058 A1 WO 2024028058A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cleansing composition
- sodium
- composition
- cleansing
- acid
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 163
- 239000007788 liquid Substances 0.000 title abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 20
- -1 sodium alkyl sulfate Chemical class 0.000 claims description 39
- 239000003945 anionic surfactant Substances 0.000 claims description 26
- 239000002888 zwitterionic surfactant Substances 0.000 claims description 23
- 239000003792 electrolyte Substances 0.000 claims description 15
- 239000011734 sodium Substances 0.000 claims description 12
- 229910052708 sodium Inorganic materials 0.000 claims description 12
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 12
- 239000003755 preservative agent Substances 0.000 claims description 11
- 229940104261 taurate Drugs 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 7
- 229940061720 alpha hydroxy acid Drugs 0.000 claims description 7
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims description 7
- 229960003237 betaine Drugs 0.000 claims description 7
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 7
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 7
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 6
- QNAYBMKLOCPYGJ-UHFFFAOYSA-M alaninate Chemical compound CC(N)C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-M 0.000 claims description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
- CAVXVRQDZKMZDB-UHFFFAOYSA-M sodium;2-[dodecanoyl(methyl)amino]ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CCS([O-])(=O)=O CAVXVRQDZKMZDB-UHFFFAOYSA-M 0.000 claims description 4
- YKXUOESQDCXGIW-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;2-(trimethylazaniumyl)acetate Chemical compound C[N+](C)(C)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC([O-])=O YKXUOESQDCXGIW-UHFFFAOYSA-N 0.000 claims description 3
- IXOCGRPBILEGOX-UHFFFAOYSA-N 3-[3-(dodecanoylamino)propyl-dimethylazaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)CS([O-])(=O)=O IXOCGRPBILEGOX-UHFFFAOYSA-N 0.000 claims description 3
- 229960002609 betaine citrate Drugs 0.000 claims description 3
- YIOHILISQLOJJV-AFEZEDKISA-N carboxymethyl-dimethyl-[(z)-octadec-9-enyl]azanium;hydroxide Chemical compound [OH-].CCCCCCCC\C=C/CCCCCCCC[N+](C)(C)CC(O)=O YIOHILISQLOJJV-AFEZEDKISA-N 0.000 claims description 3
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
- 238000004299 exfoliation Methods 0.000 claims description 3
- 238000009499 grossing Methods 0.000 claims description 3
- 229940094506 lauryl betaine Drugs 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 3
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 229940079988 potassium cocoyl glycinate Drugs 0.000 claims description 3
- 229940079781 sodium cocoyl glutamate Drugs 0.000 claims description 3
- 229940065859 sodium cocoyl glycinate Drugs 0.000 claims description 3
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 3
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 claims description 3
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 claims description 3
- 229940080352 sodium stearoyl lactylate Drugs 0.000 claims description 3
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 3
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 claims description 3
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 3
- HVYJSOSGTDINLW-UHFFFAOYSA-N 2-[dimethyl(octadecyl)azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CC([O-])=O HVYJSOSGTDINLW-UHFFFAOYSA-N 0.000 claims description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 claims description 2
- RXMUKMSXIXSYOA-UHFFFAOYSA-N carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium;hydroxide Chemical compound [OH-].CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O RXMUKMSXIXSYOA-UHFFFAOYSA-N 0.000 claims description 2
- 229940079886 disodium lauryl sulfosuccinate Drugs 0.000 claims description 2
- KHIQYZGEUSTKSB-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O.CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O KHIQYZGEUSTKSB-UHFFFAOYSA-L 0.000 claims description 2
- 238000010494 dissociation reaction Methods 0.000 claims description 2
- 230000005593 dissociations Effects 0.000 claims description 2
- 229930195712 glutamate Natural products 0.000 claims description 2
- 108700019599 monomethylolglycine Proteins 0.000 claims description 2
- 229940079776 sodium cocoyl isethionate Drugs 0.000 claims description 2
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 claims description 2
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 abstract description 26
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract description 6
- 230000000699 topical effect Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 20
- 235000002639 sodium chloride Nutrition 0.000 description 16
- 239000004094 surface-active agent Substances 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- 150000002148 esters Chemical class 0.000 description 12
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 12
- 125000000217 alkyl group Chemical group 0.000 description 11
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 9
- 239000002736 nonionic surfactant Substances 0.000 description 9
- 229940083542 sodium Drugs 0.000 description 9
- 229940093915 gynecological organic acid Drugs 0.000 description 7
- 235000005985 organic acids Nutrition 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000003086 colorant Substances 0.000 description 6
- 239000000284 extract Substances 0.000 description 6
- 230000000475 sunscreen effect Effects 0.000 description 6
- 239000000516 sunscreening agent Substances 0.000 description 6
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 150000007513 acids Chemical class 0.000 description 5
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000002335 preservative effect Effects 0.000 description 5
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 4
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 239000011324 bead Substances 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 235000015165 citric acid Nutrition 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 239000003974 emollient agent Substances 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 150000002739 metals Chemical class 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 3
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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- 239000010445 mica Substances 0.000 description 1
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- 244000005700 microbiome Species 0.000 description 1
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- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
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- 235000010446 mineral oil Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
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- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- CGVLVOOFCGWBCS-RGDJUOJXSA-N n-octyl β-d-thioglucopyranoside Chemical compound CCCCCCCCS[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CGVLVOOFCGWBCS-RGDJUOJXSA-N 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- YYELLDKEOUKVIQ-UHFFFAOYSA-N octaethyleneglycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCO YYELLDKEOUKVIQ-UHFFFAOYSA-N 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 1
- 229960000601 octocrylene Drugs 0.000 description 1
- HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical group [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000001739 pinus spp. Substances 0.000 description 1
- 229950001046 piroctone Drugs 0.000 description 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940100498 polysilicone-15 Drugs 0.000 description 1
- 229920002282 polysilicones-15 Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- 229940116985 potassium lauryl sulfate Drugs 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 239000001120 potassium sulphate Substances 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- KYLDDUZJZSKJER-NTISSMGPSA-M potassium;(4s)-5-hydroxy-5-oxo-4-(tetradecanoylamino)pentanoate Chemical compound [H+].[K+].CCCCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC([O-])=O KYLDDUZJZSKJER-NTISSMGPSA-M 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000008262 pumice Substances 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 229940094944 saccharide isomerate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000035910 sensory benefits Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940083575 sodium dodecyl sulfate Drugs 0.000 description 1
- 229940082004 sodium laurate Drugs 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 229940077092 sodium myristoyl glutamate Drugs 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229940080350 sodium stearate Drugs 0.000 description 1
- 229940045898 sodium stearoyl glutamate Drugs 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- FCBUGCHAVCFTHW-NTISSMGPSA-N sodium;(2s)-2-(tetradecanoylamino)pentanedioic acid Chemical compound [Na].CCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O FCBUGCHAVCFTHW-NTISSMGPSA-N 0.000 description 1
- KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- HJXBXTZDPSSEST-UHFFFAOYSA-M sodium;2-[methyl(tetradecanoyl)amino]ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCCC(=O)N(C)CCS([O-])(=O)=O HJXBXTZDPSSEST-UHFFFAOYSA-M 0.000 description 1
- IZWPGJFSBABFGL-GMFCBQQYSA-M sodium;2-[methyl-[(z)-octadec-9-enoyl]amino]ethanesulfonate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)N(C)CCS([O-])(=O)=O IZWPGJFSBABFGL-GMFCBQQYSA-M 0.000 description 1
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 229940100515 sorbitan Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 150000003900 succinic acid esters Chemical class 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 229960000368 sulisobenzone Drugs 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- NGSWKAQJJWESNS-ZZXKWVIFSA-N trans-4-coumaric acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C=C1 NGSWKAQJJWESNS-ZZXKWVIFSA-N 0.000 description 1
- AQWHMKSIVLSRNY-UHFFFAOYSA-N trans-Octadec-5-ensaeure Chemical class CCCCCCCCCCCCC=CCCCC(O)=O AQWHMKSIVLSRNY-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 description 1
- 229940036248 turpentine Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 239000011675 vitamin B5 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
- OWVLYQRCCIEOPF-QHTZZOMLSA-L zinc;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Zn+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 OWVLYQRCCIEOPF-QHTZZOMLSA-L 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
Definitions
- the present invention relates to liquid cleansing compositions suitable for topical application for cleansing the human body, especially the skin and hair.
- the invention relates to compositions which are preferably sulfate free, thickening agent free, and comprise an organic acid.
- the compositions lather appreciably, are stable and are very mild.
- the cleansing compositions it has been found that for personal cleansing compositions comprising certain anionic and zwitterionic surfactants, and organic acid, the cleansing compositions, surprisingly, are stable, have a desirable viscosity, and deliver consumer desirable sensory characteristics when formulated substantially free of thickening agent, electrolytes, or both.
- the cleansing composition disclosed herein is also environmentally sustainable since synthetic thickeners that are often not biodegradable may be avoided. of the Invention
- a cleansing composition comprising anionic surfactant, zwitterionic surfactant, and organic acid and/or salt or ester thereof, wherein the composition has a pH ranging from 4.0 to 6.0, or 4.15 to 4.75, or 4.25 to 5.5, and wherein the composition is substantially free of thickening agent, electrolytes, or both.
- composition comprising anionic surfactant, zwitterionic surfactant, and organic acid and/or salt or ester thereof for formulating a thickened and mild cleansing composition for smoothing skin wherein the composition is substantially free of thickening agent, electrolytes, or both.
- a method of cleansing for gentle exfoliation of the skin comprising the steps of:
- a cleansing composition comprising anionic surfactant, zwitterionic surfactant, and organic acid and/or salt or ester thereof, wherein the composition is substantially free of thickening agent, electrolytes, or both;
- a cleansing composition comprising an anionic surfactant, a zwitterionic surfactant, and an organic acid is meant to include a composition consisting essentially of the same and a composition consisting of the same. As to the percentages used herein, the same are meant to be by weight of ingredient active, unless noted otherwise.
- Esters of organic acids includes, for example, those derived from a carboxylic acid and a C2 to Cs alkanol, linear, branched, and/or functionalized with a hydroxy group.
- Salts of acids include those having a sodium (Na + ), potassium (K + ), or magnesium (Mg + ) counter ion or other solubilizing cation as defined herein.
- Cleansing compositions disclosed herein comprise at least one anionic surfactant. Desirable anionic surfactants are non-soap.
- Taurates may be used as an anionic surfactant, the same is limited only to the extent that it is one suitable for use in a consumer product.
- Illustrative examples of the taurate surfactant that may be used in the disclosed cleansing composition include, for example, those which are acylamides of taurine or N-methyltaurine, and salts thereof.
- taurates suitable for use are acyl taurates represented by the general formulae:
- R is Cs to C 3 o, more particularly, Cs to C 2 4 alkyl, y is 2 or 3, R 1 is hydrogen or methyl, and M is hydrogen or a solubilizing cation such as, for example, hydrogen, ammonium, alkali metal cation, a lower Ci to C4, alkanol ammonium cation and/or a basic amino acid cation.
- R is Cs to Cis alkyl.
- at least half of the R groups are Cs-Cis alkyl.
- at least half of the R groups are C10 to C14 alkyl.
- R may be saturated or unsaturated.
- R 1 is methyl.
- Illustrative acyl taurates that may be used as an anionic surfactant of the disclosed cleansing composition include, for example, taurates commonly known as sodium methyl lauroyl taurate, sodium methyl myristoyl taurate, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium cocoyl taurate, mixtures thereof or the like.
- the taurate used is sodium methyl lauroyl taurate.
- Anionic surfactants like taurates may be present in an amount of 0.001 to 20%, or 0.01 to 15%, or 0.5 to 12%, 1 to 10%, or 2 to 6% by weight of the cleansing composition.
- Taurate may comprise from 50 to 90% by weight of the total anionic surfactant. In another aspect, taurate makes up 100% by weight of the total anionic surfactant.
- anionic surfactants may be used in the disclosed cleansing composition in addition to taurate.
- additional anionic surfactants may include alkyl sulfosuccinates (including mono- and dialkyl, e.g., C6-C22 sulfosuccinates); alkyl and acyl sarcosinates, sulfoacetates, C8-C22 alkyl phosphates and phosphonates, alkyl phosphate esters and alkoxyl alkyl phosphate esters, acyl lactates, C8-C22 monoalkyl succinates and maleates, sulphoacetates, alkyl glucosides and acyl isethionates, acyl glutamates, glycinates, alaninates, and the like.
- Sulfosuccinates may be monoalkyl sulfosuccinates having the formula:
- R 2 CONHCH2CH 2 OC(O)CH 2 CH(SO3M)CO2M wherein R 2 ranges from C8-C22 alkyl.
- R 3 CON(CH 3 )CH 2 CO 2 M, wherein R 3 ranges from C8-C20 alkyl.
- Glycinates generally have the formula:
- R 4 CONR 5 CH 2 CO 2 M, wherein R 4 is a C8-C24 alkyl, R 5 is hydrogen or CH3.
- Acyl glutamates generally have the formula: wherein R 6 is a C8-C20 alkyl or alkenyl.
- M is a solubilizing cation as previously described.
- other desirable anionic surfactants include 2- acrylamido-2-methylpropane sulfonic acid, ammonium lauryl sulfate, ammonium perfluorononanoate, potassium lauryl sulfate, sodium alkyl sulfate, sodium dodecyl sulfate, sodium laurate, sodium laureth sulfate, sodium lauroyl sarcosinate, sodium stearate, sodium sulfosuccinate esters, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, sodium cocoyl glutamate, potassium myristoyl glutamate, disodium cocoyl glutamate, sodium cocoyl glycinate, potassium cocoyl glycinate, disodium 2-sulfolaurate, sodium stearoyl lactylate, sodium cocoyl alaninate, or a combination thereof.
- anionic surfactants are commercially available from suppliers like Galaxy Surfactants, Clariant, Sino Lion, Stepan Company, and Innospec.
- the anionic surfactant used is an isethionate, a taurate, a sodium alkyl sulfate like sodium lauryl sulfate, an acyl glutamate, a glycinate, a lactylate, an alaninate, or a mixture thereof.
- the anionic surfactants for use include sodium cocoyl alaninate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium lauryl sulfate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium cocoyl glycinate, potassium cocoyl glycinate, disodium lauryl sulfosuccinate, sodium stearoyl lactylate, or a combination thereof.
- the cleansing composition is substantially free of sulfate-based surfactants (i.e. , is sulfate free).
- the cleansing composition is free of sulfate-based surfactants. “Substantially free of,” as used herein, is intended to mean comprising less than 5% by weight, or less than 2.5% by weight, or less than 1% by weight, or less than 0.5% by weight, or less than 0.1% by weight, or 0% by weight of the ingredient.
- such surfactants include at least one acid group.
- Such an acid group may be a carboxylic or a sulphonic acid group. They often include quaternary nitrogen, and therefore, can be quaternary amino acids. They should generally include an alkyl or alkenyl group of 7 to 18 carbon atoms and generally comply with an overall structural formula:
- R 7 [— C(O)— NH(CH 2 ) q — ]r— N + (R 8 )(R 9 )-A— B , where R 7 is alkyl or alkenyl of 7 to 18 carbon atoms; R 8 and R 9 are each independently alkyl, hydroxyalkyl or carboxyalkyl of 1 to 3 carbon atoms; q is 2 to 4; r is 0 to 1 ; A is alkylene of 1 to 3 carbon atoms optionally substituted with hydroxyl, and B is — CO2 — or — SO3 — .
- Desirable zwitterionic surfactants for use in the cleansing composition disclosed herein and within the above general formula include simple betaines of formula:
- R 7 may, in particular, be a mixture of Ci 2 and C14 alkyl groups derived from coconut oil so that at least half, or at least three quarters, of the groups R 7 have 10 to 14 carbon atoms.
- R 8 and R 9 are preferably methyl.
- the zwitterionic surfactant is a sulphobetaine of formula:
- R 7 CONH(CH 2 )U— N + (R 8 )(R 9 )-(CH 2 ) 3 SO 3 - , where u is 2 or 3, or variants of these in which — (CH 2 )3SO3' is replaced by — CH 2 C(OH)(H)CH 2 SO 3 -.
- R 7 , R 8 and R 9 are as previously defined.
- Illustrative examples of the zwitterionic surfactants desirable for use include betaines such as lauryl betaine, betaine citrate, cocodimethyl carboxymethyl betaine, cocamidopropyl betaine, coco alkyldimethyl betaine, and laurylamidopropyl betaine.
- An additional zwitterionic surfactant desirable for use includes cocamidopropyl sultaine, for example, cocamidopropyl hydroxysultaine.
- Preferred zwitterionic surfactants include lauryl betaine, betaine citrate, sodium hydroxymethylglycinate, (carboxymethyl) dimethyl-3-[(1 -oxododecyl) amino] propylammonium hydroxide, coco alkyldimethyl betaine, (carboxymethyl) dimethyloleylammonium hydroxide, cocamidopropyl betaine, (carboxymethyl) dimethyloleylammonium hydroxide, cocamidopropyl betaine, (carboxylatomethyl) dimethyl(octadecyl)ammonium, cocamidopropyl hydroxysultaine, or a combination thereof.
- the zwitterionic surfactant comprises cocamidopropyl betaine.
- the cleansing composition comprises to 5 to 40%, or 10 to 35%, or 12 to 30%, or 15 to 25% zwitterionic surfactant by weight of the cleansing composition.
- the zwitterionic surfactant may comprise from 50 to 90% cocamidopropyl betaine by weight of the zwitterionic surfactant in the total surfactant system.
- cocamidopropyl betaine makes up 100% by weight of the zwitterionic surfactant in the total surfactant system.
- Nonionic surfactants may optionally be used in the cleansing composition.
- nonionic surfactants are typically used at levels as low as 0.01 , 0.1 , 1 or 2% by weight and at levels as high as 6, 8, 10 or 12% by weight.
- the nonionic surfactants which may be used include, in particular, the reaction products of compounds having a hydrophobic group and a reactive hydrogen atom, for example aliphatic alcohols, acids, amides or alkylphenols with alkylene oxides, especially ethylene oxide either alone or with propylene oxide.
- nonionic surfactant compounds are alkyl (C6-C22) phenols, ethylene oxide condensates, the condensation products of aliphatic (Cs-Cis) primary or secondary linear or branched alcohols with ethylene oxide, and products made by condensation of ethylene oxide with the reaction products of propylene oxide and ethylenediamine.
- Other nonionic surfactants include long chain tertiary amine oxides, long chain tertiary phosphine oxides, dialkyl sulphoxides, and the like.
- nonionic surfactants can include fatty acid/alcohol ethoxylates having the following structures a) HOCH2(CH2) s (CH2CH2O) c H or b) HOOC(CH2) v (CH2CH2O)d H; where s and v are each independently an integer up to 18; and c and d are each independently an integer from 1 or greater. In an aspect, s and v can be each independently 6 to 18; and c and d can be each independently 1 to 30.
- the nonionic surfactant may also include a sugar amide, such as a polysaccharide amide.
- the surfactant may be one of the lactobionamides described in U.S. Pat. No. 5,389,279 to Au et al., entitled “Compositions Comprising Nonionic Glycolipid Surfactants issued Feb. 14, 1995; which is hereby incorporated by reference or it may be one of the sugar amides described in U.S. Pat. No. 5,009,814 to Kelkenberg, titled "Use of N-Poly Hydroxyalkyl Fatty Acid Amides as Thickening Agents for Liquid Aqueous Surfactant Systems" issued Apr. 23, 1991 ; hereby incorporated into the subject application by reference.
- nonionic surfactants that can optionally be used in the cleansing compositions disclosed herein include, but are not limited to, polyglycoside, cetyl alcohol, cocamide monoethanolamine (MEA), decyl glucoside, lauryl glucoside, octaethylene glycol monododecyl ether, n-octyl beta-d-thioglucopyranoside, octyl glucoside, oleyl alcohol, polysorbate, sorbitan, stearyl alcohol, or a combination thereof.
- MAA cocamide monoethanolamine
- decyl glucoside lauryl glucoside
- octaethylene glycol monododecyl ether n-octyl beta-d-thioglucopyranoside
- octyl glucoside oleyl alcohol
- polysorbate sorbitan
- stearyl alcohol or a combination thereof.
- any organic acid commonly employed in personal care or pharmaceutical compositions may be selected.
- the organic acid is a C2-C22 carboxylic acid, or C2-C18 carboxylic acid, or C2-C16 carboxylic acid. It is desirable that the organic acid is soluble in water. Also desirable are any acids having an acid dissociation constant (pK a ) from 2 to 12, or 2 to 8, or 2 to 6.
- Desirable organic acids for use in the disclosed cleansing compositions may comprise, in a nonlimiting manner, independently or in combinations thereof, acetic acid, adipic acid, ascorbic acid, aspartic acid, benzoic acid, cinnamic acid, citric acid, fumaric acid, glutamic acid, glutaric acid, glycolic acid, hydroxybenzoic acid, hydroxycinnamic acid, lactic acid, maleic acid, malic acid, malonic acid, mandelic acid, nicotinic acid, phenylacetic acid, pimelic acid, salicylic acid, sorbic acid, tartaric acid, tartronic acid, tropic acid, gluconic acid, lactobionic acid, and organic acid and/or salt or ester thereof.
- Organic acid salts includes carboxylate salts of an organic acid (i.e. , sodium carboxylates).
- Organic acid derivatives includes esters (i.e., carboxylate esters) derived from an organic acid and a C2-C8 alkanol, or C 2 -Ce alkanol, in particular, C 2 -Ce alkyl esters.
- the C 2 -Ce alkyl group of such esters may have additional substituents such as one or more hydroxy groups.
- the organic acid comprises ascorbic acid, citric acid, glycolic acid, lactic acid, malic acid, mandelic acid, tartaric acid, and/or salts or ester thereof.
- the organic acid comprises citric acid, glycolic acid, lactic acid, mandelic acid, and/or salt or ester thereof.
- the organic acid is an alpha hydroxy acid, beta hydroxy acid, polyhydroxy acid, or mixtures thereof.
- the organic acid is an alpha hydroxy acid.
- the cleansing composition comprises 0.001 to 10%, or 0.01 to 8%, or 0.1 to 7%, or 0.5 to 6%, or 1 to 6% active organic acid and/or salts or ester thereof by weight of the cleansing composition.
- the cleansing compositions disclosed herein are stable and have a desirable viscosity when substantially free of one or more thickening agents.
- thickening agents include polysaccharides, which comprise of starches, natural/synthetic gums and cellulosics.
- Illustrative but nonlimiting starches include tapioca starch, cornstarch, potato starch, aluminum starch octenylsuccinate, and sodium hydroxypropyl starch phosphate.
- Illustrative but nonlimiting gums include acacia Senegal gum, agar, agarose, biosaccharide gum, carrageenan, cellulose, gellan gum, guar gum, hyaluronic acid, pectin, sclerotium, xanthan, and combinations thereof.
- Illustrative but nonlimiting cellulosics include hydroxypropyl cellulose, hydroxypropyl methylcellulose, ethylcellulose, and sodium carboxy methylcellulose.
- Such thickening agents may also include citric fiber and synthetic polymers functioning as thickening agents, including Carbomers, polyethylene glycol distearates, polyacrylates, polyacrylamides, polymethacrylate, acrylate copolymer, methacrylate copolymer, acrylamide copolymer, taurate copolymers, acryloyldimethyltaurate copolymer, and mixtures thereof.
- Thickening agents as used herein, may also include cationic polysaccharide polymers, specifically cationic guar gum derivatives, such as, but are not limited to, guar hydroxypropyltrimonium chloride. The compositions are unexpectedly stable in the absence of the above.
- the cleansing compositions disclosed herein are also substantially free of one or more electrolytes. Viscosity of the cleansing compositions disclosed herein are not dependent upon electrolyte inclusion. Such electrolytes include halides of alkaline metals, alkaline earth metals, ammonium and other metals, such as aluminum and zinc; sulphates and phosphates of alkaline metals, alkaline earth metals, ammonium and other metals such has aluminum and zinc; MEA and DEA salts, and alkaline metal silicates, among others.
- the cleansing composition is substantially free of electrolytes including sodium chloride, potassium chloride, sodium sulphate, potassium sulphate, magnesium chloride, magnesium sulphate, magnesium chloride, magnesium sulphate, zinc sulphate, ammonium chloride, and MEA chloride, among others and combinations thereof.
- electrolytes including sodium chloride, potassium chloride, sodium sulphate, potassium sulphate, magnesium chloride, magnesium sulphate, magnesium chloride, magnesium sulphate, zinc sulphate, ammonium chloride, and MEA chloride, among others and combinations thereof.
- Conventional buffers/pH modifiers may be used. It is desirable to include any pH modifier known in the field acceptable for use in personal care and/or pharmaceutical products.
- Illustrative but nonlimiting pH modifiers include common additives such as organic acids (e.g., citric acid), inorganic acids (e.g., hydrochloric acid), inorganic bases (e.g., sodium hydroxide and potassium hydroxide), and organic bases (e.g., triethanolamine and aminomethyl propanol). These materials are added at amounts to obtain the desired pH of the cleansing composition ranging from 4.0 to 6.0, or 4.15 to 4.75, or 4.25 to 5.5, or 4.5 to 5.0, where pH is determined using a Thermo Fisher Scientific pH meter.
- organic acids e.g., citric acid
- inorganic acids e.g., hydrochloric acid
- inorganic bases e.g., sodium hydroxide and potassium hydroxide
- organic bases e.g., triethanolamine and aminomethyl propanol
- the viscosity of the cleansing composition is typically from 1 ,000 to 50,000 cPs, or 2,000 to 30,000 cPs, or 3,000 to 30,000 cPs, or 5,000 to 20,000 cPs, or 7,000 to 15,000 cPs. Viscosity may be measured with art recognized instrumentation such as a Discovery HR-2 Hybrid Rheometer or Brookfield Viscometer, RV5 spindle for 30 seconds at 25°C and 10 rpm.
- cleansing compositions disclosed herein are isotropic. Isotropic, as used herein, refers to the structural packing the surfactants in the cleansing composition, as contrasted with lamellar compositions. In another aspect, cleansing compositions disclosed herein are flowable at a temperature of 25°C and atmospheric pressure.
- Skin benefit agents suitable for use are meant to include but not be limited to opacifiers, colorants, humectants, emollients, occlusive agents, plant extracts, optical agents, skin lightening agents, anti-inflammatory agents, anti-acne agents, antioxidants, sunscreens, photostabilizers, surfactants, wrinkle reducing agents, coloring agents, desquamation promoters, exfoliating agents, mixtures thereof or the like.
- opacifiers colorants, humectants, emollients, occlusive agents, plant extracts, optical agents, skin lightening agents, anti-inflammatory agents, anti-acne agents, antioxidants, sunscreens, photostabilizers, surfactants, wrinkle reducing agents, coloring agents, desquamation promoters, exfoliating agents, mixtures thereof or the like.
- opacifiers colorants
- humectants emollients
- occlusive agents occlusive agents
- plant extracts extracts
- humectants generally of the polyhydric alcohol-type materials, may be used in the disclosed cleansing composition.
- Typical polyhydric alcohols include glycerol (i.e., glycerine or glycerin), propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1 ,3-butylene glycol, isoprene glycol, 1 ,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and mixtures thereof.
- glycerol i.e., glycerine or glycerin
- propylene glycol dipropylene glycol
- polypropylene glycol polyethylene glycol
- sorbitol hydroxypropyl sorbitol
- hexylene glycol 1 ,3-butylene glycol
- the cleansing composition comprises glycerin, pentylene glycol, propylene glycol, sorbitol, or a mixture thereof.
- the amount of humectant employed may range anywhere from 0.1 to 20%, or 0.5 and 15%, or between 1 and 10% by weight of the cleansing composition.
- Hydrophobic emollients with weight average particle sizes below either 1000 or 500 microns in diameter are defined herein as “finely dispersed oils” and are preferably used at a minimum of 3, 2, 1 or 0% by weight and a maximum of 20, 30, 40 or 50% by weight.
- hydrophobic emollients include but are not limited to the following:
- silicone oils and modifications thereof such as linear and cyclic polydimethylsiloxanes; amino, alkyl, alkylaryl, and aryl silicone oils;
- fats and oils including natural fats and oils (triglycerides) such as jojoba, soybean, sunflower, safflower, algal, rice bran, avocado, almond, olive, sesame, persic, castor, coconut, mink oils; cacao fat; beef tallow, lard; hardened oils obtained by hydrogenating the aforementioned oils; and synthetic mono-, di- and triglycerides such as myristic acid glyceride and 2- ethylhexanoic acid glyceride;
- waxes such as carnauba, spermaceti, beeswax, lanolin, and derivatives thereof;
- hydrocarbons such as petrolatum, polybutene, liquid paraffins, microcrystalline wax, ceresin, squalene, pristan and mineral oil;
- esters such as cetyl octanoate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, glycerol monostearate, glycerol distearate, glycerol tristearate, alkyl lactate, alkyl citrate and alkyl tartrate;
- essential oils and extracts thereof such as mentha, jasmine, camphor, white cedar, bitter orange peel, ryu, turpentine, cinnamon, bergamot, citrus unshiu, calamus, pine, lavender, bay, clove, hiba, eucalyptus, lemon, starflower, thyme, peppermint, rose, sage, sesame, ginger, basil, juniper, lemon grass, rosemary, rosewood, avocado, grape, grapeseed, myrrh, cucumber, watercress, calendula, elder flower, geranium, linden blossom, amaranth, seaweed, ginko, ginseng, carrot, guarana, tea tree, jojoba, comfrey, oatmeal, cocoa, neroli, vanilla, green tea, penny royal, aloe vera, menthol, cineole, eugenol, citral, Citronelle, borneol, linalool, geraniol,
- Preferred emollients include petrolatum; natural wax; partially or fully hydrogenated triglyceride oils; and mixtures thereof.
- Preferred triglyceride oils include soybean oil or sunflower oil.
- Additional optional skin benefit agents desirable for use in the disclosed cleansing composition include minerals and skin nutrients such as milk; magnesium, calcium, copper, zinc and other metallic components; beta hydroxy acids, e.g., salicylic acid and derivatives thereof (such as 5-octanoyl salicylic acid, heptyloxy 4 salicylic acid, and 4-methoxy salicylic acid); kojic acid; hydroquinone and arbutin; resveratrol; saccharide isomerate; undecylenoyl phenylalanine; resorcinol derivatives (including thiamidol, 4-ethyl resorcinol, 4-isopropyl resorcinol, 4-hexyl resorcinol, 4-cyclopentyl resorcinol, 4-cyclohexyl resorcinol and acylated forms thereof); ceramides (e.g., Ceramide 1 , Ceramide 3, Ceramide 3B and Ceramide 6) and pseudoceramide
- Such skin benefit agents when used, collectively make up from 0.001 to 12%, or 0.05 to 7% by weight of the cleansing composition.
- Antibacterial agents like terpineol, thymol, and low molecular weight acids may also be optionally included.
- Other agents suitable for optional use include zinc pyrithione, octopirox, or mixtures thereof.
- fragrance components like eugenol, coumarin, linalyl acetate, citronellal, iris concentrate, terpinyl acetate, terpineol, thymol, pinenes (e.g., alpha and beta pinene) and citronellol may optionally be added to the cleansing composition as well.
- Also optionally suitable for use include materials like chelators (e.g., EDTA), opacifiers (like TiO 2 , particle size from 50 to 1200 nm, or 50 to 350 nm), kaolin, bentonite, zinc oxide, iron oxide, mica, Cs-22 fatty acid substituted saccharides, lipoic acid, retinoxytrimethylsilane (available from Clariant Corp, under the Silcare 1 M-75 trademark), dehydroepiandrosterone (DHEA) or mixtures thereof.
- materials like chelators e.g., EDTA
- opacifiers like TiO 2 , particle size from 50 to 1200 nm, or 50 to 350 nm
- kaolin bentonite
- zinc oxide iron oxide
- mica Cs-22 fatty acid substituted saccharides
- lipoic acid available from Clariant Corp, under the Silcare 1 M-75 trademark
- DHEA dehydroepiandrosterone
- a wide selection of botanical extracts may optionally be included in cleansing compositions disclosed herein.
- the extracts may either be soluble in water or oil, carried in a solvent that is hydrophilic or hydrophobic, respectively.
- water or ethanol are the extract solvents.
- Illustrative examples include those extracted from green tea, yarrow, chamomile, licorice, aloe vera, citrus unshui, ginko biloba, ginseng, marigold, hibiscus, willow bark, alfalfa, algae, grape seed, witch hazel, sage, thyme and rosemary, as well as oils such as those derived from sea buckthorn, moringa, argan, avocado, calendula, algal, and marula.
- Soy extracts may be used and especially when it is desirable to include retinol. Such extracts, when used, are employed individually or collectively in amounts ranging from 0.001 to 12%, or 0.01 to 7%, or 0.02 to 5%, or 0.03 to 4% by weight of the cleansing composition.
- the disclosed cleansing composition may also contain particles that are greater than 50 microns in average diameter that help remove dry skin by functioning as physical exfoliants.
- the degree of exfoliation depends on the size and morphology of the particles. Large and rough particles are usually very harsh and irritating. Very small particles may not serve as effective exfoliants.
- exfoliants used in the art include natural minerals such as silica, talc, calcite, pumice, tricalcium phosphate; seeds such as rice, apricot seeds, etc.; crushed shells such as almond and walnut shells; oatmeal; polymers such as polyethylene and polypropylene beads, flower petals and leaves; microcrystalline wax beads, synthetic wax beads, jojoba ester beads, and the like.
- These exfoliants come in a variety of particle sizes and morphology ranging from micron-sized to a few millimeters. They also have a range of hardness.
- Cleansing compositions disclosed herein may also include natural and synthetic antioxidants.
- antioxidants for use in the composition include butylated hydroxytoluene (BHT), dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, and polyphenols.
- BHT butylated hydroxytoluene
- dilauryl thiodipropionate pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate
- polyphenols polyphenols.
- the total weight percent of antioxidants comprised is from 0.01 to 4%, or from 0.02 to 3%, or from 0.05 to 2% by weight of the composition.
- Another optional additive suitable for use includes hemp oil with 2.5 to 25% by weight cannabigerol and/or cannabidiol at from 0.5 to 10 percent by weight. When used, such oil makes up from 0.0001 to 12%, or from 0.01 to 5% by weight of the cleansing composition.
- one or more coloring agent may also be included in the disclosed cleansing compositions. Coloring agents include dyes or pigments of natural or synthetic origin. A dye colorant selected for use may be organic or inorganic and water-soluble or oil-soluble. Cleansing compositions comprise from 0.01 to 20%, or 0.1 to 15%, or 0.5 to 10% by weight of the coloring agent, when used, relative to the total weight of the cleansing composition.
- sunscreens and photostabilizers include such materials as octylmethoxycinnamate (OMK), ethylhexyl salicylate, phenylbenzimidazole sulfonic acid (Ensulizole), ethylhexyl p-methoxycinnamate, available as Parsol MCX®, Avobenzene (butyl methoxydibenzoylmethane), available as Parsol 1789® and benzophenone-3, also known as oxybenzone.
- OMK octylmethoxycinnamate
- ethylhexyl salicylate ethylhexyl salicylate
- phenylbenzimidazole sulfonic acid Ensulizole
- ethylhexyl p-methoxycinnamate available as Parsol MCX®
- Avobenzene butyl methoxydibenzoylmethane
- Inorganic sunscreen actives may be employed such as microfine titanium dioxide, zinc oxide, polyethylene, and various other polymers are also desirable.
- Other sunscreens desirable for use include p-aminobenzoic acid (PABA), octyldimethyl-PABA, 2- ethoxyethyl p-methoxy cinnamate, benzophenone- 1, benzophenone-2, benzophenone-6, benzophenone-8, benzophenone-9, benzophenone-12, homomethyl salicylate, menthyl anthranilate, benzophenone-4, triethanolamine salicylate, terephthalylidene dicamphor sulfonic acid, bisoctriazole, bisethylhexyloxyphenol methoxyphenyl triazine, bisdisulizole disodium, diometriazole trisiloxane, octyltriazone, iscotrizinol, polysilicone-15, isopentenyl-4- me
- Conditioning agents like hydroxypropyltrimonium chloride, 5-ureidohydantoin and/or glyoxyldiureide may be used.
- the components when used make up from 0.5 to 4%, or 0.75 to 4%, or 1 to 3% by weight of the cleansing composition.
- Preservatives can be incorporated into the disclosed cleansing compositions as desired to protect against the growth of potentially harmful microorganisms.
- Cosmetic chemists are familiar with appropriate preservatives and routinely choose them to satisfy preservative tests and product stability tests.
- Preservative systems should be selected having regard for the use of the composition and possible incompatibilities between the preservatives and other ingredients in the formulation.
- preservatives for compositions of this invention include, without limitations, iodopropynyl butyl carbamate (IPBC), phenoxyethanol, ethylhexylglycerine, 1 ,2-octanediol, methyl paraben, propyl paraben, imidazolidinyl urea, sodium dehydroacetate, propanediol, alkyl esters of para-hydroxybenzoic acid, sodium benzoate, benzoic acid, hydroxyacetophenone, DMDM hydantoin derivatives, propionate salts, and a variety of quaternary ammonium compounds.
- IPBC iodopropynyl butyl carbamate
- phenoxyethanol ethylhexylglycerine
- 1 ,2-octanediol methyl paraben
- propyl paraben propyl paraben
- imidazolidinyl urea sodium
- Preservatives are employed in amounts ranging from 0.01 to 2% by weight of the composition, including all ranges subsumed therein. In another aspect, no traditional preservative is used in the composition if desired giving the consumer the option to have a preservative-free product.
- the cleansing composition may be free of preservative. In another aspect, the cleansing composition may comprise of a preservative system that is formaldehyde-free, paraben-free, or both.
- the cleansing composition is biodegradable, or at least 97% biodegradable.
- the cleansing composition is substantially free of silicone, sulfates, or a combination thereof.
- the cleansing composition does not contain any (i.e. , 0% by weight) silicone, sulfate, or both.
- packaging can be used to store and deliver the present cleansing composition.
- the selection of packaging is dependent upon the end-use and the viscosity of the composition itself.
- leave-on lotions and creams for skin typically employ plastic containers with an opening at a dispense end covered by an appropriate closure.
- Conventional closures include flip-top hinged lids, screw-caps and non-aerosol pumps.
- appropriate packaging to be used for antiperspirants, deodorants and depilatories include a container with a roller-ball applicator on a dispensing end if the composition is fluid and of a thinner viscosity.
- composition is in a stick format
- a container with a propel-repel mechanism wherein the stick is fixed on a platform towards a dispensing orifice is appropriate.
- metallic cans pressurized by a propellant and having a spray nozzle is appropriate.
- patches, bottles, tubes, roller-ball applicators, squeeze containers or lidded jars are preferred.
- derivative(s) refers to compounds which may be formed from a precursor compound and/or is a structural or chemical analog. All states of matter, as used herein, such as solid, liquid and gas relate to the specified state of matter at 25°C and atmospheric pressure.
- skin as used herein includes the skin on the face, neck, chest, back, arms, axilla, buttocks, hands, legs and scalp.
- Skin benefit agent as used herein, is meant to include a component that improves a facial or body characteristic after topical application like a skin characteristic and/or benefits the same wherein the skin benefit agent can be incorporated in a desirable format.
- Cleansing compositions were made according to the present invention with the ingredients and amounts set forth in Table I as four different samples. The ingredients were combined via moderate shear/agitation at atmospheric pressure and at temperature of 25 to 85°C.
- Sample A was made according to the disclosed cleansing composition. Surprisingly, Sample A is stable and possesses a desirable viscosity without having electrolyte and thickening agent.
- Sample B was not made according to the disclosed cleansing composition. Specifically, Sample B does not contain any organic acids but does comprise guar hydroxypropyltrimonium chloride, and so serves as a control with guar. Samples C and D were not made according to the disclosed cleansing composition. On stability, precipitation of guar was observed in Sample C and the resultant composition did not have a desirable viscosity, while precipitation of sclerotium gum was observed in Sample D.
- Example 2 The ingredients of the formulae made in Example 2 were mixed in a manner similar to those described in Example 1 , based on Sample A. The level of lactic acid was held constant in Example 2 at an active level of 5%.
- Example 2 unexpectedly demonstrates that the viscosity of the disclosed cleansing composition was stable without having thickening agent and/or electrolyte at the noted pH values, wherein desirable viscosities are observed in pH ranging from 4.0 to 6.0, or 4.25 to 5.5. Viscosity was measured using a Brookfield viscometer (i.e. , with RV5 spindle at a setting of 10 rpm for 30s @ 25°C.
- Example 3 The ingredients of the formulae made in Example 3 were mixed in a manner similar to those described in Example 1 , based on Sample A. The level of lactic acid was held constant in Example 3 at an active level of 5%. A salt curve was run as per conventional techniques. Table I:
- cleansing compositions made according to the compositions disclosed herein in Example 3 illustrates that the inclusion of electrolytes does not serve to thicken the formulation as in other isotropic formulations commercially available.
- Example 3 employs sodium chloride as the electrolyte analyzed.
- the pH of the sample evaluated in Example 3 has a pH of 4.45.
- Viscosity was measured using a Brookfield viscometer (i.e., with RV5 spindle at a setting of 10 rpm for 30s @ 25°C.
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Abstract
La présente invention concerne des compositions de nettoyage liquides appropriées pour une application topique pour nettoyer le corps humain, en particulier la peau et les cheveux. En particulier, l'invention concerne des compositions qui sont de préférence exemptes de sulfate, d'épaississant et qui comprennent un acide organique. De manière surprenante, les compositions ont un effet moussant appréciable sont stables et sont très douces.
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Application Number | Priority Date | Filing Date | Title |
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US202263394916P | 2022-08-03 | 2022-08-03 | |
US63/394,916 | 2022-08-03 | ||
EP22196949 | 2022-09-21 | ||
EP22196949.6 | 2022-09-21 |
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WO2024028058A1 true WO2024028058A1 (fr) | 2024-02-08 |
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PCT/EP2023/069379 WO2024028058A1 (fr) | 2022-08-03 | 2023-07-12 | Composition de nettoyage liquide |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5009814A (en) | 1987-04-08 | 1991-04-23 | Huls Aktiengesellschaft | Use of n-polyhydroxyalkyl fatty acid amides as thickening agents for liquid aqueous surfactant systems |
US5389279A (en) | 1991-12-31 | 1995-02-14 | Lever Brothers Company, Division Of Conopco, Inc. | Compositions comprising nonionic glycolipid surfactants |
EP2110119A1 (fr) * | 2008-04-15 | 2009-10-21 | KPSS-Kao Professional Salon Services GmbH | Composition de nettoyage d'épaississement par cisaillement |
WO2019011521A1 (fr) * | 2017-07-10 | 2019-01-17 | Unilever Plc | Composition à teneur élevée en glycérol comprenant des mélanges d'iséthionate d'alkyle et de taurate d'alkyle |
WO2019038309A1 (fr) * | 2017-08-25 | 2019-02-28 | Unilever Plc | Composition d'hygiène personnelle |
-
2023
- 2023-07-12 WO PCT/EP2023/069379 patent/WO2024028058A1/fr unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5009814A (en) | 1987-04-08 | 1991-04-23 | Huls Aktiengesellschaft | Use of n-polyhydroxyalkyl fatty acid amides as thickening agents for liquid aqueous surfactant systems |
US5389279A (en) | 1991-12-31 | 1995-02-14 | Lever Brothers Company, Division Of Conopco, Inc. | Compositions comprising nonionic glycolipid surfactants |
EP2110119A1 (fr) * | 2008-04-15 | 2009-10-21 | KPSS-Kao Professional Salon Services GmbH | Composition de nettoyage d'épaississement par cisaillement |
WO2019011521A1 (fr) * | 2017-07-10 | 2019-01-17 | Unilever Plc | Composition à teneur élevée en glycérol comprenant des mélanges d'iséthionate d'alkyle et de taurate d'alkyle |
WO2019038309A1 (fr) * | 2017-08-25 | 2019-02-28 | Unilever Plc | Composition d'hygiène personnelle |
Non-Patent Citations (1)
Title |
---|
"Cleansing Composition And Method ED - Darl Kuhn", IP.COM, IP.COM INC., WEST HENRIETTA, NY, US, 23 December 2018 (2018-12-23), XP013181436, ISSN: 1533-0001 * |
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