WO2024026023A3 - Double networked 3d-printed biomaterials - Google Patents
Double networked 3d-printed biomaterials Download PDFInfo
- Publication number
- WO2024026023A3 WO2024026023A3 PCT/US2023/028853 US2023028853W WO2024026023A3 WO 2024026023 A3 WO2024026023 A3 WO 2024026023A3 US 2023028853 W US2023028853 W US 2023028853W WO 2024026023 A3 WO2024026023 A3 WO 2024026023A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- double
- gelatin
- networked
- printed
- cross
- Prior art date
Links
- 239000012620 biological material Substances 0.000 title abstract 3
- 238000004132 cross linking Methods 0.000 abstract 4
- 239000000017 hydrogel Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 abstract 3
- 108010010803 Gelatin Proteins 0.000 abstract 3
- 229940072056 alginate Drugs 0.000 abstract 3
- 235000010443 alginic acid Nutrition 0.000 abstract 3
- 229920000615 alginic acid Polymers 0.000 abstract 3
- 239000008273 gelatin Substances 0.000 abstract 3
- 229920000159 gelatin Polymers 0.000 abstract 3
- 235000019322 gelatine Nutrition 0.000 abstract 3
- 235000011852 gelatine desserts Nutrition 0.000 abstract 3
- 210000004204 blood vessel Anatomy 0.000 abstract 2
- 108700004892 gelatin methacryloyl Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002227 vasoactive effect Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3808—Endothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3826—Muscle cells, e.g. smooth muscle cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
- A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials Engineering (AREA)
- Cell Biology (AREA)
- Manufacturing & Machinery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Botany (AREA)
- Urology & Nephrology (AREA)
- Dispersion Chemistry (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Optics & Photonics (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
A 3D-printed biomaterial is described that comprises a double-networked hydrogel comprising gelatin or gelatin methacryloyl and alginate, and cells. Methods of making the 3D-printed biomaterial by extruding a hydrogel comprising gelatin or gelatin methacryloyl and alginate from a 3D-printer and converting the hydrogel to a double-networked hydrogel by cross-linking the gelatin with a first cross-linking method and cross-linking the alginate with a second cross-linking method are also described. Methods of treating a damaged or diseased blood vessel and testing vasoactive drugs using 3D-printed blood vessels are also described.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202263392792P | 2022-07-27 | 2022-07-27 | |
US63/392,792 | 2022-07-27 | ||
US202363451633P | 2023-03-12 | 2023-03-12 | |
US63/451,633 | 2023-03-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2024026023A2 WO2024026023A2 (en) | 2024-02-01 |
WO2024026023A3 true WO2024026023A3 (en) | 2024-03-07 |
Family
ID=89707176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2023/028853 WO2024026023A2 (en) | 2022-07-27 | 2023-07-27 | Double networked 3d-printed biomaterials |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2024026023A2 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018053404A1 (en) * | 2016-09-19 | 2018-03-22 | The University Of Florida Research Foundation, Inc. | Methods and systems of three dimensional printing |
US20200164109A1 (en) * | 2017-07-21 | 2020-05-28 | President And Fellows Of Harvard College | Methods of producing multi-layered tubular tissue constructs |
US11339361B2 (en) * | 2017-08-31 | 2022-05-24 | United States Of America As Represented By The Secretary Of The Navy | Additive manufacturing of functional myocardial tissue |
WO2022225458A1 (en) * | 2021-04-20 | 2022-10-27 | Nanyang Technological University | Hydrogel scaffolds and uses thereof |
-
2023
- 2023-07-27 WO PCT/US2023/028853 patent/WO2024026023A2/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018053404A1 (en) * | 2016-09-19 | 2018-03-22 | The University Of Florida Research Foundation, Inc. | Methods and systems of three dimensional printing |
US20200164109A1 (en) * | 2017-07-21 | 2020-05-28 | President And Fellows Of Harvard College | Methods of producing multi-layered tubular tissue constructs |
US11339361B2 (en) * | 2017-08-31 | 2022-05-24 | United States Of America As Represented By The Secretary Of The Navy | Additive manufacturing of functional myocardial tissue |
WO2022225458A1 (en) * | 2021-04-20 | 2022-10-27 | Nanyang Technological University | Hydrogel scaffolds and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2024026023A2 (en) | 2024-02-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
L'heureux et al. | Technology insight: the evolution of tissue-engineered vascular grafts—from research to clinical practice | |
US4883487A (en) | Method of producing an artifical skin | |
Scherner et al. | In vivo application of tissue-engineered blood vessels of bacterial cellulose as small arterial substitutes: proof of concept? | |
Hahn et al. | Physiologic pulsatile flow bioreactor conditioning of poly (ethylene glycol)-based tissue engineered vascular grafts | |
Hong et al. | Preliminary study on biosynthesis of bacterial nanocellulose tubes in a novel double‐silicone‐tube bioreactor for potential vascular prosthesis | |
EP0518389A2 (en) | Coating for prosthetic devices | |
ATE295875T1 (en) | METHOD FOR PRODUCING BONE IN VITRO | |
SE543308C2 (en) | Microfluidic device facilitating perfusion of mammalian and human tissue constructs | |
US11998655B2 (en) | Collagen biomaterials and methods for manufacturing collagen biomaterials | |
US20110275795A1 (en) | Beta-glucan-based scaffold for biological tissue engineering using radiation fusion technology, and production method therefor | |
Shen et al. | A Schwann cell‐seeded intrinsic framework and its satisfactory biocompatibility for a bioartificial nerve graft | |
WO2014074134A1 (en) | Multilayered collagen scaffold | |
WO2024026023A3 (en) | Double networked 3d-printed biomaterials | |
Tosun et al. | Improved recellularization of ex vivo vascular scaffolds using directed transport gradients to modulate ECM remodeling | |
Zhang et al. | Fast-forming BMSC-encapsulating hydrogels through bioorthogonal reaction for osteogenic differentiation | |
Patel et al. | Pulsatile flow conditioning of three-dimensional bioengineered cardiac ventricle | |
Fernandez et al. | Quality control assessment of ePTFE precoating procedure for in vitro endothelial cell seeding | |
CN103933619A (en) | Nerve repairing material and preparation method thereof | |
FR2253494A1 (en) | ||
CN113150318A (en) | Preparation method and application of injectable magnesium alloy composite multi-network hydrogel | |
EP4101959A4 (en) | Artificial blood vessel and preparation method therefor | |
L’Heureux et al. | Clinical translation of tissue-engineered constructs for severe leg injuries | |
Doblado et al. | Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal Regeneration | |
CN116407680A (en) | Preparation method of 3D printing hydrogel bone repair stent and ionic crosslinking chitosan-based hydrogel | |
CN117885349A (en) | Preparation method of 3d printing ultraviolet light crosslinked antioxidant hydrogel scaffold |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 23847351 Country of ref document: EP Kind code of ref document: A2 |