WO2024016720A1

WO2024016720A1 - Personalized titanium mesh having variable thickness and preparation method therefor

Info

Publication number: WO2024016720A1
Application number: PCT/CN2023/084798
Authority: WO
Inventors: 党晓兵; 许若谷; 张春雨; 陈贤帅; 杜如虚
Original assignee: 广东中科安齿生物科技有限公司
Priority date: 2022-07-21
Filing date: 2023-03-29
Publication date: 2024-01-25
Also published as: CN115120392A

Abstract

A personalized titanium mesh having a variable thickness and a preparation method therefor. The personalized titanium mesh comprises: a first thickness region (001), a second thickness region (002), and a transition region (003), wherein the first thickness region (001), the second thickness region (002) and the transition region (003) all have first through holes (004) and second through holes (005) which are uniformly arranged, the first through holes (004) being greater than the second through holes (005); and the first thickness region (001) is connected to the second thickness region (002), the transition region (003) is located at a joint of the first thickness region (001) and the second thickness region (002), and inner and outer surfaces of the transition region (003) are in smooth transition with inner and outer surfaces of the first thickness region (001) and inner and outer surfaces of the second thickness region (002) respectively. A uniform internal stress of the structure of the personalized titanium mesh having the variable thickness can be ensured, and the mechanical properties of the personalized titanium mesh and the shaping capability during clinical use are considered.

Description

A variable thickness personalized titanium mesh and its preparation method

Technical field

The present invention relates to the technical field of oral medical equipment, and in particular to a personalized titanium mesh with variable thickness and a preparation method thereof.

Background technique

Alveolar bone defect refers to insufficient bone mass caused by periodontal disease, periapical disease, inflammatory destruction, tumors, tooth loss, congenital deformities, etc. It not only increases the difficulty of implant placement, but also affects the expected treatment effect. One effective way to address bone deficiency is guided bone regeneration surgery. Personalized titanium mesh is gradually being used in guided bone regeneration surgery due to its good mechanical properties and biocompatibility.

The existing technology of personalized titanium mesh is designed using a fully digital process. The edge of the titanium mesh closely fits the surface of the alveolar bone, which better ensures the stability of the position and reduces risks such as soft tissue exposure. For complex alveolar bone defects, Repair has obvious clinical application value. However, the currently prepared titanium mesh has a uniform thickness. After being implanted into the alveolar bone, the internal force of the titanium mesh structure is uneven. The smaller thickness of the titanium mesh has poor mechanical properties; the larger thickness of the titanium mesh has poor mechanical properties. The poor shaping ability during clinical use results in the titanium mesh not being able to fully adapt to the clinical application of different patients.

Therefore, there is an urgent need for a personalized titanium mesh and its preparation method that can ensure uniform stress within the titanium mesh structure and take into account the mechanical properties of the titanium mesh and the shaping ability during clinical use.

Contents of the invention

The present invention provides a variable-thickness personalized titanium mesh and a preparation method thereof to solve the problem in the prior art of being unable to ensure uniform stress within the titanium mesh structure and thus being unable to take into account both mechanical properties and shaping ability during clinical use. question.

In order to solve the above technical problems, embodiments of the present invention provide a personalized titanium mesh with variable thickness, including: a first thickness area, a second thickness area and a transition area; the first thickness area, the second thickness area There are evenly arranged first through holes and second through holes in both the region and the transition area, and the first through holes are larger than the second through holes;

The first thickness area and the second thickness area are connected, the transition area is located at the connection part of the first thickness area and the second thickness area, and the inner and outer surfaces of the transition area are respectively connected with the first thickness area. The inner and outer surfaces of the thickness area and the inner and outer surfaces of the second thickness area smoothly transition.

It can be understood that compared with the titanium mesh disclosed in the prior art, the variable-thickness personalized titanium mesh of the present invention can realize the optimized design of the thickness of the overall structure. Through the design of different thickness areas, in areas with greater stress, , design a larger thickness, and design a smaller thickness in areas with smaller stress, so that the personalized titanium mesh can be evenly stressed within the structure after being implanted in the alveolar bone, taking into account the mechanical properties of the titanium mesh and the The shaping ability during clinical use improves the substantive ability of personalized titanium mesh in actual clinical applications.

As a preferred solution, the thickness of the titanium mesh in the first thickness region is 0.3 mm, and the thickness of the titanium mesh in the second thickness region is 0.2 mm.

It can be understood that through the design of different thickness areas, a larger thickness is designed in the first thickness area where the stress is larger, and a smaller thickness is designed in the second thickness area where the stress is smaller, ensuring that the implanted tooth After the groove bone, the internal structure is evenly stressed at different stress points, taking into account the mechanical properties of the titanium mesh and its shaping ability during clinical use.

Correspondingly, the present invention also provides a method for preparing a variable-thickness personalized titanium mesh, which is used to prepare a variable-thickness personalized titanium mesh as described in any one of the above, including:

Construct the initial titanium mesh model;

Finite element analysis is performed on the initial titanium mesh model, and according to the results of the finite element analysis, the structural stress area of the initial titanium mesh model is divided to obtain the first thickness area and the second thickness area of the initial titanium mesh model. thickness area;

Generate a transition region at the intersection of the first thickness region and the second thickness region, thereby obtaining a personalized titanium mesh model;

The personalized titanium mesh model is prepared to obtain a personalized titanium mesh with variable thickness.

It can be understood that by introducing mechanical simulation analysis into the design process of the titanium mesh, the present invention can take into account the mechanical properties and structural characteristics of the titanium mesh, and through the optimized design of the overall structural thickness, the design can be achieved in areas with greater stress. Larger thickness, design smaller thickness in areas with less stress, so that the personalized titanium mesh can bear uniform force inside the structure after being implanted in the alveolar bone, taking into account the mechanical properties and clinical use of the titanium mesh The instant shaping ability improves the substantive ability of personalized titanium mesh in actual clinical applications. At the same time, the transition area between different thickness areas ensures the structural integrity of the personalized titanium mesh. The overall preparation method improves the preparation of titanium mesh. Accuracy and efficiency.

As a preferred solution, the initial titanium mesh model is constructed as follows:

Obtain a CT image of the patient's alveolar bone, and construct an alveolar bone model of the patient based on the CT image of the alveolar bone;

An initial titanium mesh model that fits closely with the alveolar bone model is constructed.

It can be understood that by acquiring the patient's alveolar bone CT image, the patient's alveolar bone model is constructed, thereby constructing an initial titanium mesh model that fits the alveolar bone model, ensuring that the initial titanium mesh model constructed The overall structure of the titanium mesh model can fit closely with the alveolar bone model, which improves the structural accuracy of the initial titanium mesh model and subsequent personalized titanium mesh, and avoids the need for the existing titanium mesh to be used in clinical use. Performing large-angle and large-scale shaping will cause the stress of the overall titanium mesh to change.

As a preferred solution, finite element analysis is performed on the initial titanium mesh model, specifically:

Import the initial titanium mesh model into finite element analysis software, and perform geometric cleaning and geometric feature simplification on the initial titanium mesh model;

The initial titanium mesh model after geometric cleaning and geometric feature simplification was meshed, and after determining the location of the bone nail holes, setting boundary constraints and load conditions, the meshed initial titanium mesh model was subjected to mechanical analysis. and solution, thereby completing the finite element analysis of the initial titanium mesh model.

It can be understood that by importing the initial titanium mesh model into the finite element analysis software for geometric cleaning and simplification of geometric features, the structural accuracy of the overall initial titanium mesh model can be improved, and through meshing, the location of the bone nail holes can be determined. , after setting the boundary constraints and load conditions, perform mechanical analysis and solution, which improves the accuracy of the results obtained from the finite element analysis.

As a preferred solution, after obtaining the first thickness area and the second thickness area of the initial titanium mesh model, the method further includes:

The first thickness region and the second thickness region are shelled.

It can be understood that by shelling the first thickness region and the second thickness region, it is ensured that the first thickness region and the second thickness region of the initial titanium mesh model can be more consistent with the structure of actual clinical applications, so that subsequent The prepared personalized titanium mesh can accurately fit to the human alveolar bone and reduce the foreign body sensation.

As a preferred solution, a transition region is generated at the intersection of the first thickness region and the second thickness region, thereby obtaining a personalized titanium mesh model, specifically:

Determine a transition region generated at the intersection of the first thickness region and the second thickness region based on the results of the finite element analysis;

The transition area is surface smoothed to obtain a personalized titanium mesh model.

It can be understood that by determining the transition region generated at the intersection of the first thickness region and the second thickness region through the results of the finite element analysis, the transition between the first thickness region and the second thickness region is guaranteed. The stress in the area can have high structural strength, avoiding the situation where the stress intensity in the transition area is not high, which may easily lead to structural fracture. At the same time, the surface of the transition area is smoothed, so that the overall personalized titanium mesh structure can be used in actual clinical applications. Patients reduce the occurrence of foreign body sensation.

As a preferred solution, after obtaining the personalized titanium mesh model, it also includes:

The surface mutation area of the personalized titanium mesh model is subjected to structural smoothing treatment.

It can be understood that by structurally smoothing the surface mutation areas of the personalized titanium mesh model, the subsequently prepared personalized titanium mesh can have higher structural strength, and the personalized titanium mesh can be used in actual clinical applications. , can better fit the patient's alveolar bone and reduce the foreign body sensation.

As a preferred solution, the personalized titanium mesh model is prepared to obtain a personalized titanium mesh with variable thickness, specifically:

The personalized titanium mesh model is prepared through additive manufacturing technology, and the prepared personalized titanium mesh is subjected to stress relief annealing, support removal and surface treatment, thereby obtaining a personalized titanium mesh with variable thickness.

It can be understood that the personalized titanium mesh model is prepared through additive manufacturing technology, and the prepared personalized titanium mesh is subjected to stress relief annealing, desupporting and surface treatment, so that the prepared personalized titanium mesh has variable thickness. Titanium mesh has high material strength and structural strength, which meets the actual application needs. At the same time, it ensures uniform stress inside the structure to take into account the mechanical properties of personalized titanium mesh and the shaping ability during clinical use.

Description of drawings

Figure 1: A schematic structural diagram of a personalized titanium mesh with variable thickness provided by an embodiment of the present invention;

Figure 2: A step flow chart of a method for preparing a personalized titanium mesh with variable thickness provided by an embodiment of the present invention.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts fall within the scope of protection of the present invention.

Embodiment 1

Please refer to Figure 1, which is a personalized titanium mesh with variable thickness provided by an embodiment of the present invention, including: a first thickness area 001, a second thickness area 002 and a transition area 003; the first thickness area 001, the Both the second thickness region 002 and the transition region 003 have uniformly arranged first through holes 004 and second through holes 005, and the first through holes 004 are larger than the second through holes 005.

The first thickness area 001 and the second thickness area 002 are connected, and the transition area 003 is located at the connection part of the first thickness area 001 and the second thickness area 002. The inner and outer surfaces of the transition area 003 Smoothly transition to the inner and outer surfaces of the first thickness region 001 and the inner and outer surfaces of the second thickness region 002 respectively.

It should be noted that in this embodiment, part of the second through hole 005 can be used as a bone nail fixing hole to fix the personalized titanium mesh on the alveolar bone. Furthermore, the materials that can be used for personalized titanium mesh include but are not limited to pure titanium, titanium alloys, etc., which have good biocompatibility and can avoid human immune system reactions.

As a preferred solution of this embodiment, the thickness of the titanium mesh in the first thickness region 001 is 0.3 mm, and the thickness of the titanium mesh in the second thickness region 002 is 0.2 mm.

It can be understood that through the design of different thickness areas, a larger thickness is designed in the first thickness area 001 that bears greater stress, and a smaller thickness is designed in the second thickness area 002 that bears less stress, ensuring that the implant After being inserted into the alveolar bone, the internal structure is evenly stressed at different stress points, taking into account the mechanical properties of the titanium mesh and its shaping ability during clinical use.

Implementing the embodiments of the present invention has the following effects:

Compared with the titanium mesh disclosed in the prior art, the variable-thickness personalized titanium mesh of the present invention can realize the optimal design of the thickness of the overall structure. Through the design of different thickness areas, in areas with greater stress, the design of larger Thickness, design a smaller thickness in areas with less stress, so that the personalized titanium mesh can bear uniform force inside the structure after being implanted in the alveolar bone, taking into account the mechanical properties of the titanium mesh and the plasticity during clinical use. The shaping ability improves the substantive ability of personalized titanium mesh in actual clinical applications.

Embodiment 2

Correspondingly, please refer to Figure 2. The present invention also provides a method for preparing a variable-thickness personalized titanium mesh, which is used to prepare a variable-thickness personalized titanium mesh as described in Embodiment 1 above, including the following steps S101- S104：

S101: Construct the initial titanium mesh model.

Obtain the patient's alveolar bone CT image, and construct the patient's alveolar bone model based on the alveolar bone CT image; construct an initial titanium mesh model that fits the alveolar bone model.

It should be noted that according to the alveolar bone defect, a personalized titanium mesh with uniform thickness is designed. The contour structure of the titanium mesh should meet clinical needs, and the outer contour completely covers the defective alveolar bone area.

S102: Perform finite element analysis on the initial titanium mesh model, and divide the structural stress area of the initial titanium mesh model according to the results of the finite element analysis to obtain the first thickness area and Second thickness area.

As a preferred solution, finite element analysis is performed on the initial titanium mesh model, specifically as follows:

The initial titanium mesh model is imported into the finite element analysis software, and the initial titanium mesh model is geometrically cleaned and the geometric features are simplified; the initial titanium mesh model after the geometric cleaning and geometric features are simplified is meshed, After determining the position of the bone nail holes and setting the boundary constraints and load conditions, the meshed initial titanium mesh model is subjected to mechanical analysis and solution, thereby completing the finite element analysis of the initial titanium mesh model.

It should be noted that finite element analysis software includes but is not limited to Ansys, Abaqus, LMS-Samtech, Algor, Femap/NX Nastran, HyperWorks, COMSOL Multiphysics, FEPG, etc. Import the initial titanium mesh model into the finite element analysis software, and Perform appropriate geometric cleaning and geometric feature simplification on the structural model. Select appropriate volume elements for mesh division, and the unit division model is mainly hexahedral elements. Make material settings for the finite element model and assign material-related properties to the finite element unit. Combined with clinical information, select the appropriate bone nail hole location and set boundary constraints; Set the load conditions for the area. Set the solution model to static analysis. Import the initial titanium mesh model into the solver for solution and perform mechanical analysis to complete the finite element analysis of the initial titanium mesh model.

S103: Generate a transition region at the intersection of the first thickness region and the second thickness region, thereby obtaining a personalized titanium mesh model.

The first thickness region and the second thickness region are shelled.

It should be noted that a larger thickness value is set for the corresponding part of the first thickness region to perform shelling processing; a smaller thickness value is set for the corresponding part of the second thickness region to perform shelling processing.

S104: Prepare the personalized titanium mesh model to obtain a personalized titanium mesh with variable thickness.

As a preferred solution, a transition region is generated at the intersection of the first thickness region and the second thickness region, thereby obtaining a personalized titanium mesh model, specifically as follows:

According to the results of the finite element analysis, a transition region generated at the intersection of the first thickness region and the second thickness region is determined; the transition region is surface smoothed to obtain a personalized titanium mesh model.

It should be noted that the area where the first thickness area and the second thickness area intersect, that is, the area where there is a sudden change in thickness, is divided into a transition area. Further, the area is smoothed, especially the portion with a sudden change in thickness, and the surface is smoothed, so that the thickness of the first thickness area and the second thickness area gradually changes.

It should be noted that the personalized titanium mesh model was partially modified and the surface mutation areas were structurally smoothed to complete the model design of the personalized titanium mesh with variable thickness.

It should be noted that when additive manufacturing technology is used to process and manufacture titanium mesh, the selected material can be pure titanium or titanium alloy powder, and the selected processing method can be a laser-based powder bed fusion process. After the additive manufacturing is completed, the titanium mesh is post-processed through processes such as stress relief annealing, support removal, and surface treatment.

It can be understood that the personalized titanium mesh model is prepared through additive manufacturing technology, and the prepared personalized titanium mesh is subjected to stress relief annealing, support removal and surface treatment, so that the prepared personalized titanium mesh with variable thickness Titanium mesh has high material strength and structural strength, which meets the actual application needs. At the same time, it ensures uniform stress inside the structure to take into account the mechanical properties of personalized titanium mesh and the shaping ability during clinical use.

By introducing mechanical simulation analysis into the design process of the titanium mesh, the embodiment of the present invention can take into account the mechanical properties and structural characteristics of the titanium mesh, and through the optimized design of the thickness of the overall structure, larger areas can be designed in areas with greater stress. Thickness, design a smaller thickness in areas with less stress, so that the personalized titanium mesh can bear uniform force inside the structure after being implanted in the alveolar bone, taking into account the mechanical properties of the titanium mesh and the plasticity during clinical use. The shape ability improves the substantive ability of personalized titanium mesh in actual clinical applications. At the same time, the transition area between different thickness areas ensures the structural integrity of the personalized titanium mesh. The overall preparation method improves the preparation accuracy and accuracy of titanium mesh. efficiency.

The above-mentioned specific embodiments further describe the purpose, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above-mentioned are only specific embodiments of the present invention and are not intended to limit the scope of the present invention. . It is particularly pointed out that for those skilled in the art, any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

A personalized titanium mesh with variable thickness, characterized by comprising: a first thickness region, a second thickness region and a transition region; the first thickness region, the second thickness region and the transition region all exist There are first through-holes and second through-holes evenly arranged, and the first through-hole is larger than the second through-hole;

The first thickness area and the second thickness area are connected, the transition area is located at the connection part of the first thickness area and the second thickness area, and the inner and outer surfaces of the transition area are respectively connected with the first thickness area. The inner and outer surfaces of the thickness area and the inner and outer surfaces of the second thickness area smoothly transition.
A personalized titanium mesh with variable thickness according to claim 1, characterized in that the thickness of the titanium mesh in the first thickness region is 0.3 mm, and the thickness of the titanium mesh in the second thickness region is 0.2 mm.
A method for preparing a variable-thickness personalized titanium mesh, characterized in that it is used to prepare a variable-thickness personalized titanium mesh as claimed in claims 1-2, including:

Construct the initial titanium mesh model;

Finite element analysis is performed on the initial titanium mesh model, and according to the results of the finite element analysis, the structural stress area of the initial titanium mesh model is divided to obtain the first thickness area and the second thickness area of the initial titanium mesh model. thickness area;

Generate a transition region at the intersection of the first thickness region and the second thickness region, thereby obtaining a personalized titanium mesh model;

The personalized titanium mesh model is prepared to obtain a personalized titanium mesh with variable thickness.
A method for preparing a variable-thickness personalized titanium mesh as claimed in claim 3, characterized in that the construction of an initial titanium mesh model is specifically:

Obtain a CT image of the patient's alveolar bone, and construct an alveolar bone model of the patient based on the CT image of the alveolar bone;

An initial titanium mesh model that fits closely with the alveolar bone model is constructed.
The method for preparing a variable-thickness personalized titanium mesh according to claim 3, characterized in that the finite element analysis is performed on the initial titanium mesh model, specifically:

Import the initial titanium mesh model into finite element analysis software, and perform geometric cleaning and geometric feature simplification on the initial titanium mesh model;

The initial titanium mesh model after geometric cleaning and geometric feature simplification was meshed, and after determining the location of the bone nail holes, setting boundary constraints and load conditions, the meshed initial titanium mesh model was subjected to mechanical analysis. and solution, thereby completing the finite element analysis of the initial titanium mesh model.
The method for preparing a personalized titanium mesh with variable thickness according to claim 3, characterized in that, after obtaining the first thickness area and the second thickness area of the initial titanium mesh model, it further includes:

The first thickness region and the second thickness region are shelled.
The method for preparing a variable-thickness personalized titanium mesh according to claim 3, characterized in that a transition region is generated at the intersection of the first thickness region and the second thickness region, thereby obtaining Personalized titanium mesh model, specifically:

Determine a transition region generated at the intersection of the first thickness region and the second thickness region based on the results of the finite element analysis;

The transition area is surface smoothed to obtain a personalized titanium mesh model.
The method for preparing a variable-thickness personalized titanium mesh according to claim 7, wherein: After the personalized titanium mesh model, it also includes:

The surface mutation area of the personalized titanium mesh model is subjected to structural smoothing treatment.
A method for preparing a variable-thickness personalized titanium mesh according to claim 3, wherein the personalized titanium mesh model is prepared to obtain a variable-thickness personalized titanium mesh, specifically: :

The personalized titanium mesh model is prepared through additive manufacturing technology, and the prepared personalized titanium mesh is subjected to stress relief annealing, support removal and surface treatment, thereby obtaining a personalized titanium mesh with variable thickness.