WO2023283447A3 - Méthodes liées à une conformation alternative de la protéine de spicule sars-cov-2 - Google Patents

Méthodes liées à une conformation alternative de la protéine de spicule sars-cov-2 Download PDF

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Publication number
WO2023283447A3
WO2023283447A3 PCT/US2022/036555 US2022036555W WO2023283447A3 WO 2023283447 A3 WO2023283447 A3 WO 2023283447A3 US 2022036555 W US2022036555 W US 2022036555W WO 2023283447 A3 WO2023283447 A3 WO 2023283447A3
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WIPO (PCT)
Prior art keywords
cov
sars
methods related
spike protein
alternative conformation
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PCT/US2022/036555
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English (en)
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WO2023283447A2 (fr
Inventor
Susan MARQUSEE
Shawn M. COSTELLO
Sophie R. SHOEMAKER
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Cz Biohub Sf, Llc
The Regents Of The University Of California
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Application filed by Cz Biohub Sf, Llc, The Regents Of The University Of California filed Critical Cz Biohub Sf, Llc
Publication of WO2023283447A2 publication Critical patent/WO2023283447A2/fr
Publication of WO2023283447A3 publication Critical patent/WO2023283447A3/fr

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18—Water
    • G01N33/1826—Organic contamination in water

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Databases & Information Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Signal Processing (AREA)
  • Medicinal Chemistry (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Biophysics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des méthodes liées à une conformation alternative nouvellement découverte de la protéine de spicule du SARS-COV-2.
PCT/US2022/036555 2021-07-09 2022-07-08 Méthodes liées à une conformation alternative de la protéine de spicule sars-cov-2 WO2023283447A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163220388P 2021-07-09 2021-07-09
US63/220,388 2021-07-09
US202163287278P 2021-12-08 2021-12-08
US63/287,278 2021-12-08

Publications (2)

Publication Number Publication Date
WO2023283447A2 WO2023283447A2 (fr) 2023-01-12
WO2023283447A3 true WO2023283447A3 (fr) 2023-06-01

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ID=84801044

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Application Number Title Priority Date Filing Date
PCT/US2022/036555 WO2023283447A2 (fr) 2021-07-09 2022-07-08 Méthodes liées à une conformation alternative de la protéine de spicule sars-cov-2

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WO (1) WO2023283447A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150353637A1 (en) * 2014-06-06 2015-12-10 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150353637A1 (en) * 2014-06-06 2015-12-10 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NARANG DOMINIC, JAMES D. ANDREW, BALMER MATTHEW T., WILSON DEREK J.: "Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 32, no. 7, 7 July 2021 (2021-07-07), US , pages 1593 - 1600, XP093070646, ISSN: 1044-0305, DOI: 10.1021/jasms.0c00465 *
YANG LIPING; BRODERICK DAVID; CAMPBELL YAN; GOMBART ADRIAN F.; STEVENS JAN F.; JIANG YUAN; HSU VICTOR L.; BISSON WILLIAM H.; MAIER: "Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS & PROTEOMICS, vol. 1864, no. 12, 3 September 2016 (2016-09-03), Netherlands , pages 1667 - 1677, XP029766532, ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2016.08.019 *

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WO2023283447A2 (fr) 2023-01-12

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