WO2023279042A3 - Compositions and methods for detection of severe acute respiratory syndrome coronavirus 2 variants - Google Patents

Compositions and methods for detection of severe acute respiratory syndrome coronavirus 2 variants Download PDF

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Publication number
WO2023279042A3
WO2023279042A3 PCT/US2022/073285 US2022073285W WO2023279042A3 WO 2023279042 A3 WO2023279042 A3 WO 2023279042A3 US 2022073285 W US2022073285 W US 2022073285W WO 2023279042 A3 WO2023279042 A3 WO 2023279042A3
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Prior art keywords
variants
compositions
methods
detection
acute respiratory
Prior art date
Application number
PCT/US2022/073285
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French (fr)
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WO2023279042A2 (en
Inventor
Isabelle PHILIPP
Wing-Sum LEE
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Siemens Healthcare Laboratory, Llc
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Application filed by Siemens Healthcare Laboratory, Llc filed Critical Siemens Healthcare Laboratory, Llc
Publication of WO2023279042A2 publication Critical patent/WO2023279042A2/en
Publication of WO2023279042A3 publication Critical patent/WO2023279042A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present disclosure describes the design and characterization of genomic assays for detecting SARS CoV-2 variants. The present disclosure provides compositions and methods associated with such assays.
PCT/US2022/073285 2021-07-02 2022-06-30 Compositions and methods for detection of severe acute respiratory syndrome coronavirus 2 variants WO2023279042A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163217789P 2021-07-02 2021-07-02
US63/217,789 2021-07-02

Publications (2)

Publication Number Publication Date
WO2023279042A2 WO2023279042A2 (en) 2023-01-05
WO2023279042A3 true WO2023279042A3 (en) 2023-02-23

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PCT/US2022/073285 WO2023279042A2 (en) 2021-07-02 2022-06-30 Compositions and methods for detection of severe acute respiratory syndrome coronavirus 2 variants

Country Status (1)

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WO (1) WO2023279042A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116426617B (en) * 2023-04-25 2024-04-16 无锡市人民医院 High-sensitivity mutation detection system based on hairpin structure and enzyme digestion mechanism and application
US11911461B1 (en) 2023-05-05 2024-02-27 D4 Labs, Llc Adjuvanted vaccines containing modified S1 Spike protein of SARS-CoV-2 variant C.1.2 for subcutaneous administration and methods of use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111139241A (en) * 2020-04-03 2020-05-12 苏州吉玛基因股份有限公司 Small interfering nucleic acid for inhibiting novel coronavirus, composition and application
WO2020257356A2 (en) * 2019-06-18 2020-12-24 Mammoth Biosciences, Inc. Assays and methods for detection of nucleic acids
WO2021067527A1 (en) * 2019-10-02 2021-04-08 Rutgers, The State University Of New Jersey Assay methods and kits for detecting rare sequence variants
KR102260264B1 (en) * 2020-03-06 2021-06-03 기초과학연구원 A Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020257356A2 (en) * 2019-06-18 2020-12-24 Mammoth Biosciences, Inc. Assays and methods for detection of nucleic acids
WO2021067527A1 (en) * 2019-10-02 2021-04-08 Rutgers, The State University Of New Jersey Assay methods and kits for detecting rare sequence variants
KR102260264B1 (en) * 2020-03-06 2021-06-03 기초과학연구원 A Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19)
CN111139241A (en) * 2020-04-03 2020-05-12 苏州吉玛基因股份有限公司 Small interfering nucleic acid for inhibiting novel coronavirus, composition and application

Also Published As

Publication number Publication date
WO2023279042A2 (en) 2023-01-05

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