WO2023246358A1 - 高频qrs波形数据分析方法、装置、计算机设备与存储介质 - Google Patents
高频qrs波形数据分析方法、装置、计算机设备与存储介质 Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 65
- 230000004865 vascular response Effects 0.000 claims abstract description 56
- 238000012216 screening Methods 0.000 claims abstract description 12
- 230000007423 decrease Effects 0.000 claims description 81
- 230000004043 responsiveness Effects 0.000 claims description 72
- 230000002792 vascular Effects 0.000 claims description 58
- 238000001914 filtration Methods 0.000 claims description 24
- 238000007405 data analysis Methods 0.000 claims description 21
- 238000004458 analytical method Methods 0.000 claims description 13
- 210000004204 blood vessel Anatomy 0.000 claims description 10
- 230000000875 corresponding effect Effects 0.000 description 199
- 238000012937 correction Methods 0.000 description 17
- 238000010586 diagram Methods 0.000 description 14
- 230000006870 function Effects 0.000 description 14
- 230000008569 process Effects 0.000 description 13
- 238000001514 detection method Methods 0.000 description 12
- 238000012360 testing method Methods 0.000 description 8
- 238000000718 qrs complex Methods 0.000 description 7
- 238000011084 recovery Methods 0.000 description 6
- 230000005189 cardiac health Effects 0.000 description 5
- 210000004351 coronary vessel Anatomy 0.000 description 5
- 230000016507 interphase Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 230000000630 rising effect Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 238000002586 coronary angiography Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000034225 regulation of ventricular cardiomyocyte membrane depolarization Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
- A61B5/346—Analysis of electrocardiograms
- A61B5/349—Detecting specific parameters of the electrocardiograph cycle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
- A61B5/346—Analysis of electrocardiograms
- A61B5/349—Detecting specific parameters of the electrocardiograph cycle
- A61B5/366—Detecting abnormal QRS complex, e.g. widening
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
Definitions
- the present application relates to the technical field of medical instruments, and in particular to a high-frequency QRS waveform data analysis method, device, computer equipment and storage medium.
- Coronary vascular responsiveness can be referred to as coronary vascular responsiveness or vascular responsiveness. It can be used to characterize the immediate response ability of blood vessels to rapid expansion of blood supply, and can be provided to doctors as one of the indicators for evaluating the vitality of myocardial cells. , so that doctors can accurately identify the heart health status of the subject based on clinical symptoms. Therefore, how to accurately assess vascular responsiveness is an issue worthy of attention.
- coronary vascular responsiveness is usually assessed through invasive methods such as coronary angiography.
- this invasive method will have a greater or lesser impact on the physical health of the subject.
- ECG electrocardiogram
- this non-invasive method will not have a negative impact on the physical health of the subject, the accuracy of the assessment is low. Therefore, there are differences between non-invasive and non-destructive methods. The issue of accuracy cannot be balanced.
- a high-frequency QRS waveform data analysis method device, computer equipment, and storage medium are provided.
- a high-frequency QRS waveform data analysis method includes:
- the vascular responsiveness is determined based on the ratio of the voltage difference corresponding to the screened high-frequency QRS waveform data to the maximum voltage.
- screening high-frequency QRS waveform data whose first relative amplitude drop value is greater than or equal to a first preset threshold includes:
- the waveform characteristics of the first category include: the first relative value of amplitude decrease is greater than or equal to the first preset threshold, and the first relative value of amplitude increase is greater than or equal to the second preset threshold;
- the waveform characteristics of the second category include: the first relative amplitude decrease value is greater than or equal to the first preset threshold, the second amplitude increase relative value is less than the third preset threshold, and the duration of the second reference waveform data is greater than Or equal to the preset duration threshold;
- the waveform characteristics of the third category include: a first amplitude decrease relative value greater than or equal to the first preset threshold, a second amplitude increase relative value greater than or equal to the third preset threshold, and second reference waveform data.
- the duration is greater than or equal to the preset duration threshold;
- the step of determining the relative value of the first amplitude increase includes:
- the step of determining the relative value of the second amplitude increase includes:
- a second amplitude rise relative value is determined based on respective root mean square voltages of the end point of the second reference waveform data and the sixth reference point.
- screening high-frequency QRS waveform data whose first relative amplitude drop value is greater than or equal to a first preset threshold includes:
- the waveform characteristics of the first category include: the first relative value of amplitude decrease is greater than or equal to the first preset threshold, and the first relative value of amplitude increase is greater than or equal to the second preset threshold;
- the waveform characteristics of the second category include: the first relative amplitude decrease value is greater than or equal to the first preset threshold, the second amplitude increase relative value is less than the third preset threshold, and the duration of the second reference waveform data is greater than Or equal to the preset duration threshold;
- the waveform characteristics of the third category include: a first amplitude decrease relative value greater than or equal to the first preset threshold, a second amplitude increase relative value greater than or equal to the third preset threshold, and second reference waveform data.
- the duration is greater than or equal to the preset duration threshold;
- the step of determining the relative value of the first amplitude increase includes:
- the step of determining the relative value of the second amplitude increase includes:
- a second amplitude rise relative value is determined based on respective root mean square voltages of the end point of the second reference waveform data and the sixth reference point.
- determining the vascular responsiveness based on the ratio of the voltage difference corresponding to the filtered high-frequency QRS waveform data to the maximum voltage includes:
- the reference index includes the ratio of the voltage difference to the maximum voltage, and also includes at least one of the relative value of the target amplitude drop and the area of the target waveform drop area;
- the vascular responsiveness is determined based on the reference index.
- the method further includes:
- Determining the vascular response capability based on the ratio of the voltage difference corresponding to the screened high-frequency QRS waveform data and the maximum voltage includes:
- the reference index is determined based on the screened high-frequency QRS waveform data, and the vascular response capability is determined based on the reference index and the number of positives; the reference index includes the ratio of the voltage difference to the maximum voltage, and also includes the relative value of the target amplitude decrease , at least one of the target waveform falling area areas.
- a high-frequency QRS waveform data analysis device includes:
- a selection module for selecting high-frequency QRS waveform data in the first time period as the first reference waveform data
- the selection module is also configured to determine the first reference point based on the point with the smallest root mean square voltage in the first reference waveform data, and determine the point with the largest root mean square voltage that is earlier than the first reference point. second reference point;
- An index determination module configured to determine a first amplitude drop relative value based on the respective root mean square voltages of the first reference point and the second reference point;
- the indicator determination module is also used to determine the maximum voltage according to the high-frequency QRS waveform data
- the selection module is used to select the point with the maximum root mean square voltage from the high-frequency QRS waveform data in the second time period as the third reference point, and the time is later than the third reference point and the root mean square The point with the smallest voltage is used as the fourth reference point;
- the indicator determination module is also used to determine the voltage difference according to the respective root mean square voltages of the third reference point and the fourth reference point;
- a screening module used to screen high-frequency QRS waveform data whose first relative amplitude drop value is greater than or equal to the first preset threshold
- the indicator determination module is used to determine the vascular response capability based on the ratio of the voltage difference corresponding to the filtered high-frequency QRS waveform data and the maximum voltage.
- the screening module is also used to screen high-frequency QRS waveform data whose corresponding waveform categories are the first category, the second category and the third category;
- the waveform characteristics of the first category include: first The relative value of the amplitude decrease is greater than or equal to the first preset threshold, and the first relative value of the amplitude increase is greater than or equal to the second preset threshold;
- the waveform characteristics of the second category include: the first relative value of the amplitude decrease is greater than or equal to the The first preset threshold, the relative value of the second amplitude increase is less than the third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset duration threshold;
- the waveform characteristics of the third category include: first amplitude decrease The relative value is greater than or equal to the first preset threshold, the second amplitude rise relative value is greater than or equal to the third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset duration threshold;
- the selection module is also used to select a fifth reference point that meets the filtering condition from the first reference waveform data; the time of the fifth reference point is later than the first reference point;
- the indicator determination module is further configured to determine a first amplitude rise relative value based on the respective root mean square voltages of the first reference point and the fifth reference point;
- the selection module is also used to select second reference waveform data whose amplitude fluctuation amplitude is less than or equal to the preset fluctuation amplitude from the high-frequency QRS waveform data in the second time period; from the high-frequency QRS waveform data in the third time period; Select the point with the maximum root mean square voltage from the high-frequency QRS waveform data as the sixth reference point;
- the indicator determination module is further configured to determine a second amplitude rise relative value based on the respective root mean square voltages of the end point of the second reference waveform data and the sixth reference point.
- the filtering module is also used to filter high-frequency QRS waveform data whose corresponding waveform category is the first category; or, filter high-frequency QRS waveform data whose corresponding waveform category is the second category; or, filter The corresponding waveform category is the third category of high-frequency QRS waveform data;
- the waveform characteristics of the first category include: the first relative amplitude decrease value is greater than or equal to the first preset threshold, and the first amplitude increase relative value is greater than or equal to the first preset threshold value.
- the waveform characteristics of the second category include: the first relative amplitude decrease value is greater than or equal to the first preset threshold value, the second amplitude increase relative value is less than the third preset threshold value, and the second reference waveform The duration of the data is greater than or equal to the preset duration threshold;
- the waveform characteristics of the third category include: the first relative amplitude decrease value is greater than or equal to the first preset threshold value, and the second amplitude increase relative value is greater than or equal to the a third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset duration threshold;
- the selection module is also used to select a fifth reference point that meets the filtering condition from the first reference waveform data; the time of the fifth reference point is later than the first reference point;
- the indicator determination module is further configured to determine a first amplitude rise relative value based on the respective root mean square voltages of the first reference point and the fifth reference point;
- the selection module is also used to select second reference waveform data whose amplitude fluctuation amplitude is less than or equal to the preset fluctuation amplitude from the high-frequency QRS waveform data in the second time period; from the high-frequency QRS waveform data in the third time period; Select the point with the maximum root mean square voltage from the high-frequency QRS waveform data as the sixth reference point;
- the indicator determination module is further configured to determine a second amplitude rise relative value based on the respective root mean square voltages of the end point of the second reference waveform data and the sixth reference point.
- the indicator determination module is also used to determine a reference indicator based on the filtered high-frequency QRS waveform data; the reference indicator includes the ratio of the voltage difference to the maximum voltage, and also includes the relative value of the target amplitude drop. , at least one of the target waveform descending area areas; determining the vascular response capability according to the reference index.
- the indicator determination module is also used to determine the number of positives according to the high-frequency QRS waveform data corresponding to the exercise ECG data; according to the voltage difference corresponding to the filtered high-frequency QRS waveform data and the maximum The ratio of voltages and the positive number determine the vascular responsiveness; or, determine a reference index based on the screened high-frequency QRS waveform data, and determine the vascular responsiveness based on the reference index and the positive number; the reference index It includes the ratio of the voltage difference to the maximum voltage, and also includes at least one of the relative value of the target amplitude drop and the area of the target waveform drop area.
- a computer device includes a memory and a processor.
- the memory stores computer-readable instructions.
- the processor executes the computer-readable instructions, the steps in each method embodiment are implemented.
- a computer-readable storage medium has computer-readable instructions stored thereon. When the computer-readable instructions are executed by a processor, the steps in each method embodiment are implemented.
- Figure 1 is a schematic flowchart of a high-frequency QRS waveform data analysis method according to one or more embodiments.
- FIG. 2 is a schematic diagram of selecting reference points based on high-frequency QRS waveform data according to one or more embodiments.
- FIG. 3 is a schematic diagram of selecting reference points and reference waveform data based on high-frequency QRS waveform data according to one or more embodiments.
- FIG. 4 is a schematic diagram of selecting reference points and reference waveform data based on high-frequency QRS waveform data in another embodiment.
- Figure 5 is a schematic flowchart of a high-frequency QRS waveform data analysis method in another embodiment.
- Figure 6 is a structural block diagram of a high-frequency QRS waveform data analysis device according to one or more embodiments.
- Figure 7 is an internal structure diagram of a computer device according to one or more embodiments.
- the high-frequency QRS waveform data analysis method provided by this application can be applied to terminals, servers, and interactive systems including terminals and servers, and is implemented through the interaction between terminals and servers, which is not specifically limited here.
- the terminal can be, but is not limited to, various personal computers, laptops, smartphones, tablets, ECG monitoring equipment and portable wearable devices.
- the server can be implemented as an independent server or a server cluster composed of multiple servers.
- a high-frequency QRS waveform data analysis method is provided.
- the application of this method to a server is used as an example to illustrate, specifically including the following steps:
- Exercise ECG data refers to the ECG data collected during stress exercise ECG testing.
- Stress exercise ECG testing is an ECG testing method that increases the heart load through a certain amount of exercise to collect the subject's ECG data so that the subject's heart health status can be analyzed based on the collected ECG data. It is widely used in the detection of heart disease and cardiovascular disease.
- Exercise ECG data includes multiple QRS complexes that reflect changes in left and right ventricular depolarization potentials and times. Each QRS complex is a collection of Q waves, R waves, and S waves in the electrocardiogram. Based on the QRS wave group in the exercise ECG data, the corresponding high-frequency QRS waveform data can be obtained. The high-frequency QRS waveform data corresponds to the high-frequency QRS waveform curve.
- the high-frequency QRS waveform data includes the data of each point on the high-frequency QRS waveform curve. (such as time and root mean square voltage), thus, the corresponding high-frequency QRS waveform curve can be determined based on the high-frequency QRS waveform data.
- High-frequency QRS waveform data/high-frequency QRS waveform curve is used to characterize the changing trend of the root mean square voltage of the high-frequency component of the subject's QRS complex over time during the entire stress exercise ECG testing process, that is, it is used to Reflects the energy change trend during the entire stress exercise ECG testing process.
- the high-frequency QRS waveform data is presented through the high-frequency QRS waveform diagram.
- the abscissa is time, which corresponds to the detection time of the stress exercise ECG detection process.
- the unit is min (minutes), and the ordinate is the root mean square.
- Voltage (RMS voltage), root mean square voltage can also be understood as intensity or amplitude, and the unit is uV (microvolt).
- the exercise ECG data includes the ECG (electrocardiogram) corresponding to each heartbeat of the subject during the entire stress exercise ECG testing process.
- the ECG includes the QRS wave complex.
- the exercise ECG data is divided into multiple ECG data subsets according to timing and preset movement steps through the window function. Each ECG data subset includes ECG corresponding to multiple heartbeats.
- the ECG or QRS complexes corresponding to the multiple heartbeats included are sequentially aligned, averaged and band-pass filtered to obtain the corresponding high-frequency QRS complex (high-frequency QRS complex). band), calculate the root mean square of the high-frequency QRS wave group to obtain the corresponding root mean square voltage, which is used as the root mean square voltage/intensity/amplitude corresponding to the ECG data subset.
- the corresponding high-frequency QRS waveform data is obtained according to the root-mean-square voltage and corresponding time corresponding to each ECG data subset, so that the curve smoothing processing of each root-mean-square voltage in the high-frequency QRS waveform data is performed according to the time sequence to obtain the corresponding high-frequency QRS waveform curve. Or, perform curve smoothing processing on the root mean square voltage corresponding to each ECG data subset according to the time sequence to obtain the corresponding high-frequency QRS waveform curve, and obtain the corresponding high frequency QRS waveform curve based on the time and root mean square voltage of each point on the high-frequency QRS waveform curve. Frequency QRS waveform data.
- the window length and preset movement step of the window function can be customized according to actual needs.
- the window length is set to 10 seconds
- the preset movement step is set to 10 seconds or one heartbeat cycle.
- One heartbeat cycle refers to The time interval between two adjacent heartbeats is not specifically limited here. According to the timing, it refers to the order of the detection time according to the signal acquisition time/stress exercise ECG detection process.
- the stress exercise ECG detection process includes multiple stages, which may include three stages in sequence: a resting stage, an exercise stage, and a recovery stage.
- the exercise ECG data includes ECG data at each stage. It can be understood that the division of stages is not limited to this, and can be divided according to actual conditions.
- 10 electrode pads distributed on the chest and limbs of the human body can be used to form 12 ECG leads (such as V1, V2, V3, V4, V5, V6, I, II, III, aVL, aVF and aVR), correspondingly output 12 sets of ECG data, and obtain the exercise ECG data corresponding to the entire stress exercise ECG detection process.
- the 10 electrode sheets are only used as an example and are not used to specifically limit the number of electrode sheets. The specific number can be dynamically determined according to actual needs, such as a greater or smaller number of electrode sheets. Therefore, the exercise ECG data includes ECG data corresponding to at least one ECG lead. By separately analyzing the high-frequency components of the QRS complex in the ECG data corresponding to each ECG lead, the high-frequency components corresponding to each ECG lead are obtained. Frequency QRS waveform data.
- S104 Select the high-frequency QRS waveform data in the first time period as the first reference waveform data.
- the first time period may be a time interval determined by a preset start time point and a preset end time point, or may be a time interval determined by a preset start time point and a preset duration.
- the first period of time may specifically include a period of time before exercise and a period of time during exercise, or may include a period of time during exercise, with the period before exercise being in the resting phase and the period during exercise being in the exercise phase, such as after the start of exercise. a period of time.
- the first time period is, for example, the time interval represented by [1 minute 20 seconds, 6 minutes], and the first time period includes exercise The first 100 seconds before, the first 3 minutes of exercise, the first time period is also a time interval represented by [3 minutes, 6 minutes], and the first time period includes the first 3 minutes of exercise. It can be understood that the above examples are only for illustration and not for specific limitation.
- the first reference waveform data is the data in the high-frequency QRS waveform data whose time is within the first time period. The time of each point in the first reference waveform data is within the first time period.
- the starting point and end point of the first reference waveform data are The respective times are respectively the starting time point and the ending time point of the first time period.
- the starting point of the first reference waveform data refers to the earliest point in the first reference waveform data, that is, it refers to the first point in the first reference waveform data when sorted in time sequence.
- the definition of the end point is similar and will not be repeated here.
- S106 Determine the first reference point based on the point with the smallest root mean square voltage in the first reference waveform data, and determine the second reference point based on the point that is earlier than the first reference point and has the largest root mean square voltage.
- the position of each point in the first reference waveform data is determined by the time and root mean square voltage of the point.
- the root mean square voltage of each point in the first reference waveform data is traversed according to the time sequence. Based on the traversed root mean square voltage, from Select the point with the minimum root mean square voltage from the first reference waveform data, determine the first reference point based on the point with the minimum root mean square voltage, and select the time earlier/less than the first reference point from the first reference waveform data. , and the point where the root mean square voltage is the largest, and the second reference point is determined based on the point where the root mean square voltage is the largest.
- the filtered point with the smallest root mean square voltage is used as the first reference point, or the point with the smallest root mean square voltage is corrected according to a preconfigured first correction coefficient, and the point with the smallest root mean square voltage is modified by The obtained point serves as the first reference point.
- the root mean square voltage corresponding to the point where the root mean square voltage is the smallest is corrected by a preconfigured first correction coefficient to obtain the corrected root mean square voltage, and the root mean square voltage in the first reference waveform data is combined with the root mean square voltage.
- the point where the corrected root mean square voltage is consistent is selected as the first reference point.
- the second reference point is determined based on the second correction coefficient and the filtered point with the maximum root mean square voltage, which will not be described again here.
- the first correction coefficient and the second correction coefficient can be customized, or can be dynamically determined based on the user profile of the subject. Specifically, they can be functions determined based on the user profile. The first correction coefficient is greater than 1, and the second correction coefficient is less than 1.
- the user portrait includes at least one of the subject's age, gender, weight, clinical symptoms, living habits, etc.
- S108 Determine the first amplitude decrease relative value based on the respective root mean square voltages of the first reference point and the second reference point.
- the root mean square voltages of the first reference point and the second reference point are respectively obtained, and the root mean square voltage of the second reference point is compared with the root mean square voltage of the first reference point to obtain
- the first amplitude drop absolute value is determined by determining the ratio of the first amplitude drop absolute value to the root mean square voltage of the second reference point as the first amplitude drop relative value.
- the maximum voltage can be understood as the maximum power, which can be used to reflect the maximum heart pumping function of the subject.
- the maximum value of the root mean square voltage is obtained from the high-frequency QRS waveform data as the target voltage, and the corresponding maximum voltage is determined based on the target voltage.
- the target voltage can be determined as the maximum voltage, or the target voltage can be corrected through a preconfigured third correction coefficient to obtain the maximum voltage.
- the third correction coefficient can be customized according to the actual situation. For example, if the sum of the third correction coefficient and the target voltage is used as the maximum voltage, the third correction coefficient can be set to 1uV (microvolt). The product of the voltage is used as the maximum voltage, then the third correction coefficient can be set to 1.2.
- the target voltage or the target voltage corrected by the third correction coefficient can also be rounded up to obtain the maximum voltage.
- the target voltage or the target voltage corrected by the third correction coefficient is 9.6uV, then by rounding up Rounding determines the maximum voltage to be 10 uV.
- the third correction coefficient and the correction method of the target voltage are not specifically limited here.
- the maximum value of the root mean square voltage is obtained from the high-frequency QRS waveform data corresponding to the electrocardiogram lead as the target voltage. If there is more than one ECG lead (multiple), the maximum value of the root mean square voltage is obtained from the high-frequency QRS waveform data corresponding to each ECG lead, and the maximum value of the root mean square voltage is compared, and based on The maximum root mean square voltage is selected from the comparison as the target voltage. In this way, the maximum voltage is determined based on the target voltage.
- the high-frequency QRS waveform data corresponding to each electrocardiogram lead not only includes data on each point on the corresponding high-frequency QRS waveform curve, but also includes the maximum voltage determined according to one or more embodiments of the present application. .
- S112 Select the point with the largest root mean square voltage from the high-frequency QRS waveform data in the second time period as the third reference point, and select the point with the smallest root mean square voltage later than the third reference point as the fourth reference point. Reference point.
- the second time period may specifically include a period of time before exercise, during exercise, and a period after exercise.
- the period before exercise is in the resting phase, during exercise includes the entire exercise phase, and the period after exercise is in the recovery phase.
- the period before exercise, exercise is in the recovery phase.
- the period before exercise, exercise is a continuous period of time.
- the second time period is, for example, the time interval represented by [1 minute 20 seconds, 9 minutes 20 seconds], which is based on time point 1 Minutes and 20 seconds are used as the starting time point, and the time point is 9 minutes and 20 seconds as the ending time point.
- the second time period includes 100 seconds before exercise, 6 minutes during exercise, and 20 seconds after exercise.
- the second time period includes the first time period, and the starting time point of the second time period may be the same as the starting time point of the first time period.
- traverse the root mean square voltage of each point in the high-frequency QRS waveform data in the second time period and based on the traversed root mean square voltage, filter the root mean square voltage from the high-frequency QRS waveform data in the second time period.
- the point with the maximum voltage is used as the third reference point, and the point with time later/greater than the time of the third reference point and with the smallest root mean square voltage is used as the fourth reference point.
- the third reference point and the second reference point may be the same point, which is specifically determined by corresponding high-frequency QRS waveform data. If there are multiple points with the maximum root mean square voltage in the high-frequency QRS waveform data in the second time period, select the earliest point from the multiple points with the maximum root mean square voltage as the third reference point.
- S114 Determine the voltage difference based on the root mean square voltages of the third reference point and the fourth reference point.
- the root mean square voltage of the third reference point is compared with the root mean square voltage of the corresponding fourth reference point to obtain the voltage difference corresponding to the corresponding high frequency QRS waveform data.
- the voltage difference can be understood as the absolute value of the amplitude drop, and specifically it can be the second absolute value of the amplitude drop in one or more embodiments of this application.
- FIG. 2 provides a schematic diagram of selecting reference points based on high-frequency QRS waveform data.
- the high-frequency QRS waveform graph shows the high-frequency QRS waveform curve determined based on the high-frequency QRS waveform data corresponding to ECG lead II.
- the abscissa is time in minutes, and the ordinate is root mean square. Voltage/amplitude, unit is microvolt.
- the corresponding time range of the movement phase in the high-frequency QRS waveform data is 0 to 6 minutes.
- the first time period is the time interval corresponding to [100 seconds before 0, 3 minutes]
- the second time period is The time period is the time interval corresponding to [100 seconds before 0, 6 minutes and 20 seconds].
- the first reference waveform data includes the data in the first time period in the high-frequency QRS waveform data.
- the first reference point is the first reference waveform data.
- the point where the root mean square voltage is the smallest the second reference point is the point in the first reference waveform data that is earlier than the first reference point and the root mean square voltage is the largest, and the third reference point is the point where the root mean square voltage is the largest in the second time period.
- the point with the maximum voltage, the fourth reference point is the point in the second time period that is later than the third reference point and the root mean square voltage is the minimum.
- the third reference point and the second reference point are the same point
- the fourth reference point and the first reference point are the same point
- the maximum voltage is 12uV (as shown/displayed in the high-frequency QRS waveform diagram
- the voltage difference (absolute value of the second amplitude drop) determined based on the third reference point and the fourth reference point is 4.8uV
- the relative value of the second amplitude drop is 53%.
- S116 Screen the high-frequency QRS waveform data whose first relative amplitude drop value is greater than or equal to the first preset threshold.
- the first preset threshold can be customized based on experience value, such as 40%, or can be dynamically determined based on the user profile of the subject.
- the user profile includes at least one of the parameters such as age, weight, gender, and load level. There is no specific limitation here.
- high-frequency QRS waveform data corresponding to the first amplitude drop relative value greater than or equal to the first preset threshold is screened from each high-frequency QRS waveform data corresponding to the exercise ECG data, so as to facilitate based on the Screened high-frequency QRS waveform data determines vessel responsiveness.
- the first time period includes a period of time before movement and a period of time during movement
- filter the first relative amplitude decrease value to be greater than or equal to the first preset threshold, and the first reference point and the second reference point
- the time interval between the high-frequency QRS waveform data is less than or equal to the preset time interval, so as to determine the ratio of the voltage difference to the maximum voltage based on the filtered high-frequency QRS waveform data, or to include the ratio of the voltage difference to the maximum voltage. Reference index to further determine vascular responsiveness.
- the preset time interval can be customized according to actual conditions, such as 3 minutes.
- each high-frequency QRS waveform data if the first amplitude decrease relative values of each high-frequency QRS waveform data corresponding to the exercise ECG data are less than the first preset threshold, there is no need to further determine the corresponding vascular response capability, and each high-frequency QRS waveform data is output.
- QRS waveform data is for doctors’ reference. It can be understood that when the vascular responsiveness is determined and output, each high-frequency QRS waveform data can also be output synchronously for the doctor's reference.
- S118 Determine the blood vessel response capability according to the ratio of the voltage difference corresponding to the filtered high-frequency QRS waveform data and the maximum voltage.
- Vascular responsiveness is used to characterize the difference in coronary vascular responsiveness for reference by doctors, so that doctors can accurately identify heart health conditions based on vascular responsiveness and clinical symptoms, so as to provide further diagnosis, treatment or testing reference suggestions.
- the ratio of the voltage difference to the maximum voltage can be determined based on the corresponding voltage difference and the maximum voltage. Further, the vascular response capability is determined based on the ratio of the voltage difference corresponding to each of the filtered high-frequency QRS waveform data and the maximum voltage.
- the maximum value of the ratio of the voltage difference to the maximum voltage is screened, and based on the filtered voltage difference and the maximum voltage
- the ratio of voltages determines the responsiveness of the blood vessel. For example, if the ratios of the voltage difference and the maximum voltage corresponding to the three filtered high-frequency QRS waveform data are 16%, 40% and 52% respectively, then based on 52% (the maximum value of the ratio of the voltage difference to the maximum voltage ) to determine vascular responsiveness. It can be understood that the maximum value of the filtered ratio of the voltage difference to the maximum voltage can be understood as the target ratio of the voltage difference to the maximum voltage.
- the corresponding voltage difference can be determined for each piece of high-frequency QRS waveform data corresponding to the exercise ECG data. with maximum voltage. It is also possible to determine the corresponding voltage difference and the maximum voltage for each filtered high-frequency QRS waveform data after filtering the high-frequency QRS waveform data whose first amplitude drop relative value is greater than or equal to the first preset threshold.
- the ratio of the voltage difference to the maximum voltage can reflect the coronary vessel responsiveness, and the two have a negative correlation. Therefore, the responsiveness of the corresponding blood vessel can be determined based on the ratio of the voltage difference to the maximum voltage. If the ratio of the voltage difference to the maximum voltage is greater, the corresponding blood vessel responsiveness will be marked as lower or smaller (the higher the priority of attention) to characterize The less responsive the coronary vessels are. Specifically, the corresponding vascular response capability can be determined according to the ratio threshold interval in which the ratio of the voltage difference to the maximum voltage is located.
- the ratio of the voltage difference to the maximum voltage is related to the individual differences of the subjects. Therefore, based on the ratio, it can be accurately determined The subject's vascular responsiveness was assessed.
- a total of four ratio threshold intervals from the first ratio threshold interval to the fourth ratio threshold interval with reference priorities decreasing in sequence are preconfigured, for example, they are: greater than or equal to 46%, greater than or equal to 40% and less than 46%, Greater than or equal to 30% and less than 40%, greater than or equal to 16% and less than 30%, if the ratio of the voltage difference to the maximum voltage is within the first ratio threshold interval, mark the vascular response capability as the first level with the highest priority of attention. If the ratio of the voltage difference to the maximum voltage is within the second ratio threshold interval, then the vascular response capability is marked as the second level with the next highest attention priority, and so on, which will not be listed here.
- the vascular response capability can be marked as the lowest priority level, or the determination based on the ratio of the voltage difference to the maximum voltage may not be performed.
- the vascular responsiveness can also be determined based on other reference indicators provided in this application.
- the reference index is determined based on each of the filtered high-frequency QRS waveform data, and the reference index is determined according to the reference index.
- the reference index includes the ratio of the voltage difference to the maximum voltage, and also includes at least one of the relative value of the target amplitude drop and the area of the target waveform drop area. It can be understood that the number of positives can also be determined based on each high-frequency QRS waveform data corresponding to the exercise ECG data, and the vascular response capability can be determined based on the number of positives and the reference index (ratio of voltage difference to maximum voltage).
- the ratio of the voltage difference to the maximum voltage in the reference index means that the relative value of the corresponding first amplitude drop is greater than Or the maximum value among the ratios of the voltage difference and the maximum voltage corresponding to each high-frequency QRS waveform data equal to the first preset threshold.
- the target amplitude drop relative value means that the corresponding first amplitude drop relative value is greater than or equal to the first preset.
- the target waveform drop area area refers to each high-frequency QRS waveform whose corresponding first amplitude drop relative value is greater than or equal to the first preset threshold. The sum, average or maximum value of the waveform falling area area corresponding to the data.
- the above high-frequency QRS waveform data analysis method by analyzing the high-frequency QRS waveform data corresponding to the exercise ECG data, selects two characteristic points in the first time period as the first reference point and the second reference point respectively, and selects the The two characteristic points in the second time period are respectively used as the third reference point and the fourth reference point, and the corresponding maximum voltage is determined. Based on the first reference point and the second reference point, the high-frequency QRS waveform data is quantified in the first time period. The first relative amplitude decrease value is obtained based on the waveform change, and the voltage difference representing the degree of amplitude decrease is quantified based on the third reference point and the fourth reference point.
- the waveform changes characterizing the high-frequency QRS waveform data meet the requirements, a more accurate vascular response ability can be obtained based on the ratio of the voltage difference to the maximum voltage.
- the subject's coronary vascular response can be accurately assessed non-invasively.
- the more accurate vascular response capability can be provided to doctors for reference, so that doctors can accurately identify the heart health status of the subject based on clinical symptoms.
- S116 includes: filtering high-frequency QRS waveform data whose corresponding waveform categories are the first category, the second category, and the third category; the waveform characteristics of the first category include: the first amplitude drop relative value is greater than or equal to the first category.
- a preset threshold, and the first relative amplitude increase value is greater than or equal to the second preset threshold;
- the waveform characteristics of the second category include: the first amplitude decrease relative value is greater than or equal to the first preset threshold, and the second amplitude increase relative value is less than the third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset duration threshold;
- the waveform characteristics of the third category include: the first amplitude drop relative value is greater than or equal to the first preset threshold, the second amplitude The rising relative value is greater than or equal to the third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset duration threshold;
- the step of determining the first amplitude rising relative value includes: selecting from the first reference waveform data that satisfies The fifth reference point of the filtering condition; the time of the fifth reference point is later than the first reference point; the first amplitude rise relative value is determined based on the respective root mean square voltages of the first reference point
- the first category includes V-shaped
- the second category includes L-shaped
- the third category includes U-shaped.
- the filtering condition is a constraint used to filter the fifth reference point from the first reference waveform data. Specifically, it can be the end point of the first reference waveform data, or it can be that the time in the first reference waveform data is later than/greater than the first reference The first turning point of the point.
- the inflection point also known as the inflection point, refers to the point that changes the upward or downward direction of the curve, that is, it refers to the dividing point between the concave arc and the convex arc on the curve corresponding to the first reference waveform data.
- the third time period may specifically include a period of time after exercise in the recovery phase.
- the third time period may be adjacent to the second time period, for example, the end time point of the second time period is the starting time point of the third time period. Taking the corresponding time range of the recovery phase in the high-frequency QRS waveform curve as 9 to 12 minutes as an example, the third time period is, for example, the time interval represented by [9 minutes, 20 seconds, 12 minutes].
- the amplitude fluctuation amplitude is used to characterize the degree of fluctuation or change of the amplitude. Specifically, it can be used to characterize the degree of fluctuation between the amplitudes (that is, the root mean square voltage) of each point in the second reference waveform data.
- the amplitude fluctuation amplitude of the second reference waveform data can be specifically determined based on the maximum value and the minimum value of the root mean square voltage in the second reference waveform data. For example, the corresponding amplitude can be obtained by making the difference between the maximum value and the minimum value of the root mean square voltage. Fluctuation range.
- the preset fluctuation amplitude can be customized according to needs, such as 1uV (microvolt).
- the preset fluctuation amplitude can also be dynamically determined based on the root mean square voltage of the second reference point or the third reference point.
- the preset fluctuation amplitude is the same as the second reference point. (or the third reference point) has a positive correlation.
- the preset fluctuation amplitude can be dynamically determined based on the root mean square voltage of the second reference point (or the third reference point) and the preset proportion value. For example, Ten percent of the root mean square voltage of the second reference point or the third reference point is determined as the preset fluctuation amplitude.
- the preset proportion value of ten percent is only used as an example and is not used for specific limitations.
- the duration of the second reference waveform data refers to the difference between the corresponding times of the end point and the start point of the second reference waveform data.
- the second preset threshold, the third preset threshold and the preset duration threshold can be customized according to experience values. For example, the second preset threshold is set to 30%, the third preset threshold is set to 56%, and the preset threshold is 56%. Assume that the duration threshold is set to 3 minutes, which can also be dynamically determined based on the user portrait of the subject, and is not specifically limited here.
- each high-frequency QRS waveform data corresponding to the exercise ECG data is the first category, the second category, or the third category, and filter the corresponding waveform categories into the first category, the second category, and the third category respectively.
- the third category of high-frequency QRS waveform data is used to filter out the high-frequency QRS waveform data whose waveform category is the first category and the high-frequency QRS waveform data whose waveform category is the second category from the high-frequency QRS waveform data corresponding to the exercise ECG data.
- the filtered high-frequency QRS waveform data includes: high-frequency QRS waveform data of the first category, and high-frequency QRS waveform data of the second category. and the third category of high-frequency QRS waveform data, so as to determine the vascular responsiveness based on the ratio of the voltage difference corresponding to the filtered high-frequency QRS waveform data and the maximum voltage.
- the step of analyzing whether the waveform category of the high-frequency QRS waveform data is the first category includes: selecting the end point of the first reference waveform data as the fifth reference point, or selecting the end point after the first reference point from the first reference waveform data.
- the first inflection point is used as the fifth reference point; the difference between the root mean square voltage of the fifth reference point and the root mean square voltage of the first reference point is used to obtain the first amplitude rise absolute value, and the first amplitude rise absolute value is compared with the first amplitude rise absolute value.
- the ratio of the root mean square voltage of the reference point is determined as the first relative amplitude increase value; if the first amplitude decrease relative value is greater than or equal to the first preset threshold, and the first amplitude increase relative value is greater than or equal to the second preset threshold, Then it is determined that the waveform category of the corresponding high-frequency QRS waveform data is the first category.
- the step of analyzing whether the waveform category of the high-frequency QRS waveform data is the second category includes: traversing the root mean square voltage of each point in the high frequency QRS waveform data in the second time period, based on the traversed root mean square voltage, from Select the data whose amplitude fluctuation is less than or equal to the preset fluctuation amplitude from the high-frequency QRS waveform data in the second time period as the second reference waveform data; select the data in the third time period from the high-frequency QRS waveform data, Traverse the root mean square voltage of each point in the selected data, and select the point with the largest root mean square voltage from the selected data as the sixth reference point based on the traversed root mean square voltage; use the mean square voltage of the sixth reference point
- the difference between the root voltage and the root mean square voltage at the end point of the second reference waveform data is used to obtain the second amplitude rise absolute value, and the ratio of the second amplitude rise absolute value to the root mean square voltage at the end point of the second reference waveform data
- the waveform category of the corresponding high-frequency QRS waveform data is determined to be the second category.
- the duration of the second reference waveform data is determined based on the respective times of the starting point and the end point of the second reference waveform data.
- the step of analyzing whether the waveform category of the high-frequency QRS waveform data is the third category includes: traversing the root mean square voltage of each point in the high frequency QRS waveform data in the second time period, based on the traversed root mean square voltage, starting from Select the data whose amplitude fluctuation is less than or equal to the preset fluctuation amplitude from the high-frequency QRS waveform data in the second time period as the second reference waveform data; select the data in the third time period from the high-frequency QRS waveform data, Traverse the root mean square voltage of each point in the selected data, and select the point with the largest root mean square voltage from the selected data as the sixth reference point based on the traversed root mean square voltage; use the mean square voltage of the sixth reference point
- the difference between the root voltage and the root mean square voltage at the end point of the second reference waveform data is used to obtain the second amplitude rise absolute value, and the ratio of the second amplitude rise absolute value to the root mean square voltage at the end point of the second reference waveform
- the waveform category of the corresponding high-frequency QRS waveform data is determined to be the third category.
- the high-frequency QRS waveform data corresponding to each of the 12 ECG leads there are 2 high-frequency QRS waveform data whose waveform category is the first category, and there are 2 pieces of high-frequency QRS waveform data whose waveform category is the second category. There is one piece of high-frequency QRS waveform data, and there is one piece of high-frequency QRS waveform data whose waveform category is the third category. Then, the corresponding waveform categories are selected from the 12 pieces of high-frequency QRS waveform data as the first category, the second category, and the third category. Category high-frequency QRS waveform data, and determine the vascular responsiveness based on the 4 selected high-frequency QRS waveform data.
- the high-frequency QRS waveform data in the second time period is used as the target waveform data.
- the existing technology may be referred to select a second reference whose amplitude fluctuation is less than or equal to the preset fluctuation amplitude from the target waveform data. Waveform data will not be described again here.
- the amplitude fluctuation is less than or equal to the preset fluctuation amplitude
- the short duration such as 1 minute or 30 seconds
- the amplitude fluctuation corresponding to the candidate data after the expanded range still meets the requirements, then according to The above method continues to expand the candidate data until the amplitude fluctuation amplitude corresponding to the expanded candidate data does not meet the requirements, then the range expansion of the candidate data is stopped, and the candidate data obtained by the previous range expansion is determined as the second reference waveform data.
- the curve determined based on the second reference waveform data is a continuous sub-segment in the corresponding high frequency QRS waveform curve.
- whether the waveform category of each piece of high-frequency QRS waveform data is the first category, the second category, or the third category is analyzed in a parallel or serial manner.
- the analysis can be performed in sequence according to the waveform analysis function corresponding to each preset category in the preset order. If it is determined based on the current waveform analysis function that the waveform category of the high-frequency QRS waveform data is not the corresponding preset category, then follow the The preset sequence continues analysis based on the waveform analysis function corresponding to the next preset category until the stop condition is met and the current analysis process is stopped.
- the stop condition includes traversing all preset categories in the preset sequence, or based on the current waveform analysis.
- the function determines that the waveform category of high-frequency QRS waveform data is the corresponding preset category.
- the preset sequence is not specifically limited here.
- the default category includes a first category, a second category, and a third category. If the default category includes more or fewer categories, similar logic can be referred to for processing. If the waveform type of the high-frequency QRS waveform data is any one of the preset types (that is, the waveform type of the high-frequency QRS waveform data is any one of the first type, the second type, and the third type), then it is determined that the high-frequency The waveform category of QRS waveform data is a preset category.
- the waveform analysis function corresponding to the preset category may include the relevant steps of analyzing whether the high-frequency QRS waveform data is of the corresponding preset category provided in one or more embodiments of the present application, which will not be described again here.
- the high-frequency QRS waveform data whose waveform category is the first category, the second category or the third category can better reflect the coronary vascular response ability. Therefore, the corresponding waveform category is screened into the first category, the second category and the third category of high-frequency QRS waveform data, so as to obtain more accurate vascular response capabilities based on the filtered high-frequency QRS waveform data.
- the waveform categories are filtered to be high-frequency QRS waveform data of the first category and the second category, or the waveform categories are screened to be high-frequency QRS waveform data of the first category and the third category, or the waveform category is screened to be The high-frequency QRS waveform data of the second category and the third category, and the vascular responsiveness is determined based on the filtered high-frequency QRS waveform data.
- the preset category includes a first category and a second category, or a first category and a third category, or a second category and a third category, so that the high frequency of the preset category is based on the waveform category. QRS waveform data determines vessel responsiveness.
- S116 includes: filtering the high-frequency QRS waveform data whose corresponding waveform category is the first category; or filtering the high-frequency QRS waveform data whose corresponding waveform category is the second category; or filtering the corresponding waveform category is the third category.
- the waveform characteristics of the first category include: the first relative amplitude decrease value is greater than or equal to the first preset threshold, and the first amplitude increase relative value is greater than or equal to the second preset threshold; the second category The waveform characteristics include: the first relative value of amplitude decrease is greater than or equal to the first preset threshold, the second relative value of amplitude increase is less than the third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset duration threshold;
- the waveform characteristics of the third category include: the first relative value of amplitude decrease is greater than or equal to the first preset threshold, the second relative value of amplitude increase is greater than or equal to the third preset threshold, and the duration of the second reference waveform data is greater than or equal to Preset duration threshold; the step of determining the relative value of the first amplitude rise includes: selecting a fifth reference point that meets the filtering conditions from the first reference waveform data; the time of the fifth reference point is later than the first reference point
- each piece of high-frequency QRS waveform data corresponding to the exercise ECG data is the first category, and filter out the high-frequency QRS waveform data whose corresponding waveform category is the first category, so that the waveform category is the first category.
- the ratio of the voltage difference corresponding to the category of high-frequency QRS waveform data to the maximum voltage determines the vascular responsiveness.
- analyze whether the waveform category of each high-frequency QRS waveform data corresponding to the exercise ECG data is the second category, and filter the high-frequency QRS waveform data whose corresponding waveform category is the second category, so that the waveform category is the second category.
- the ratio of the voltage difference corresponding to the high-frequency QRS waveform data to the maximum voltage determines the vascular responsiveness. Or, analyze whether the waveform category of each piece of high-frequency QRS waveform data corresponding to the exercise ECG data is the third category, and filter out the high-frequency QRS waveform data whose corresponding waveform category is the third category, so that the waveform category is the third category. The ratio of the voltage difference corresponding to the high-frequency QRS waveform data to the maximum voltage determines the vascular responsiveness.
- the first relative value of amplitude decrease is greater than or equal to the first preset threshold, and the first relative value of amplitude increase is greater than or equal to the second preset threshold, it indicates that the corresponding high-frequency QRS waveform data includes a V-shaped band.
- the waveform category corresponding to the corresponding high-frequency QRS waveform data is V-type (first category)
- each high-frequency QRS corresponding to the V-type waveform category is Waveform data further determines vessel responsiveness. It can be understood that the waveform category of the high-frequency QRS waveform data shown in Figure 2 is V-shaped.
- the waveform changes of the high-frequency QRS waveform data are quantified through the waveform analysis function corresponding to the V-type to analyze whether the waveform category of the high-frequency QRS waveform data is V-type, so that on this basis, based on the waveform category of V-type
- Each high-frequency QRS waveform curve accurately determines vascular responsiveness.
- the threshold represents that the corresponding high-frequency QRS waveform data includes an L-shaped band, and then the waveform category of the corresponding high-frequency QRS waveform data is determined to be L-shaped, so as to further determine the vascular response capability based on each high-frequency QRS waveform data with the waveform category being L-shaped.
- the waveform changes of the high-frequency QRS waveform data are quantified through the waveform analysis function corresponding to the L-type to analyze whether the waveform category of the high-frequency QRS waveform data is L-type, so that on this basis, based on the waveform category of L-type
- Each high-frequency QRS waveform data accurately determines vascular responsiveness.
- FIG. 3 provides a schematic diagram of selecting reference points and reference waveform data based on high-frequency QRS waveform data.
- the high-frequency QRS waveform chart shows the high-frequency QRS waveform data corresponding to the electrocardiogram lead aVL.
- the corresponding time range in the high-frequency QRS waveform data during the exercise phase is 0 to 9 minutes.
- the first time period Including the first 3 minutes of exercise (exercise phase), the high-frequency QRS waveform data in the first time period is the first reference waveform data, and the point with the smallest root mean square voltage in the first reference waveform data is the first reference point.
- the point in the first reference waveform data that is earlier than the first reference point and has the maximum root mean square voltage is used as the second reference point.
- the second time period includes 100 seconds before exercise (in the resting phase) and 9 minutes during the exercise phase. 20 seconds after exercise (in the recovery phase), the data in the second time period, and the amplitude waveform amplitude is less than or equal to the preset fluctuation amplitude (such as 0.5uV) is the second reference waveform data, in the second time period
- the point with the largest root mean square voltage is the third reference point, and the point with the smallest root mean square voltage later than the third reference point is the fourth reference point.
- the third time period includes from the 20th second after the end of the exercise to the load.
- the time interval at which the motion detection process ends is the sixth reference point , based on the root mean square voltages of the third reference point and the fourth reference point, the determined absolute value of the second amplitude drop and the relative value of the second amplitude drop are 3.3uV and 56% respectively.
- the high-frequency QRS waveform shown in Figure 3 The maximum voltage and voltage difference corresponding to the data are 10uV and 3.3uV respectively, and the waveform category is L-shaped. It can be understood that in the high-frequency QRS waveform curve shown in the figure, the first reference point and the fourth reference point are the same point.
- the high-frequency QRS waveform data shown in Figure 3 and the corresponding selected reference points and reference waveform data, as well as the selection of the first reference point and the second reference point are only examples and are not used for specific limitations.
- the duration threshold is set to indicate that the corresponding high-frequency QRS waveform data includes a U-shaped band, then the waveform category of the corresponding high-frequency QRS waveform data is determined to be U-shaped, and the vascular response is further determined based on each high-frequency QRS waveform curve whose waveform category is U-shaped. ability.
- the waveform changes of the high-frequency QRS waveform data are quantified through the waveform analysis function corresponding to the U-shape to analyze whether the waveform category of the high-frequency QRS waveform data is U-shaped, so that on this basis, based on the waveform category being U-shaped
- Each high-frequency QRS waveform data accurately determines vascular responsiveness.
- FIG. 4 provides a schematic diagram of selecting reference points and reference waveform data based on high-frequency QRS waveform data.
- the high-frequency QRS waveform data corresponding to the electrocardiogram lead V5 is displayed in the high-frequency QRS waveform data.
- the corresponding time range in the high-frequency QRS waveform data during the exercise phase is 0 to 9 minutes.
- the first time period Including the 100 seconds before exercise (in the resting phase) and the first 3 minutes during exercise (in the exercise phase), the high-frequency QRS waveform data in the first time period is the first reference waveform data, and all the first reference waveform data
- the point with the smallest root-mean-square voltage is the first reference point.
- the point in the first reference waveform data that is earlier than the first reference point and has the largest root-mean-square voltage is the second reference point.
- the second time period includes the 100 seconds before exercise. (in the resting phase), 9 minutes in the exercise phase and 20 seconds after exercise (in the recovery phase), the data in the second time period and the amplitude waveform amplitude is less than or equal to the preset fluctuation amplitude (such as 0.5uV) is
- the point with the maximum rms voltage in the second time period is the third reference point
- the point with the time later than the third reference point and the minimum rms voltage is the fourth reference point.
- the point in the third time period is the second reference waveform data.
- the high-frequency QRS waveform data in the third time period are all The point with the largest root-square voltage is the sixth reference point. Based on the respective root-mean-square voltages of the third reference point and the fourth reference point, the determined absolute value of the second amplitude drop and the relative value of the second amplitude drop are 3.2uV and 3.2uV respectively. 63%.
- the maximum voltage and voltage difference corresponding to the high-frequency QRS waveform data shown in Figure 4 are 10uV and 3.2uV respectively, and its waveform category is U-shaped.
- the second reference point and the third reference point are the same point.
- the high-frequency QRS waveform data shown in Figure 4 and the corresponding selected reference points and reference waveform data, as well as the selection of the first reference point and the second reference point are only examples and are not used for specific limitations.
- the respective waveform characteristics of the first category, the second category, and the third category also include: first The time interval between the reference point and the second reference point is less than or equal to the preset time interval.
- the waveform characteristics of the first category include: the first relative amplitude decrease value is greater than or equal to the first preset threshold, and the first amplitude increase relative value is greater than or equal to the second preset threshold value, and the first reference The time interval between the point and the second reference point is less than or equal to the preset time interval, and will not be listed here.
- S118 includes: determining a reference index based on the filtered high-frequency QRS waveform data; the reference index includes the ratio of the voltage difference to the maximum voltage, and also includes at least the relative value of the target amplitude drop and the area of the target waveform drop area.
- One item determination of vascular responsiveness based on reference indicators.
- the ratio of voltage difference to maximum voltage in the reference index refers to the maximum value among the ratios of voltage difference to maximum voltage corresponding to each filtered high-frequency QRS waveform data, which can be understood as the target ratio of voltage difference to maximum voltage.
- the target amplitude drop relative value refers to the maximum value of the second amplitude drop relative values corresponding to each filtered high-frequency QRS waveform data
- the target waveform drop area area refers to the waveform corresponding to each filtered high-frequency QRS waveform data. The sum, average, or maximum value of the area of the drop zone.
- the ratio of the voltage difference to the maximum voltage is determined based on the screened high-frequency QRS waveform data, and at least one of the reference indicators such as the relative value of the target amplitude drop and the target waveform drop area area is also determined, and the voltage difference and the maximum voltage are determined.
- the vascular response capability is determined by combining at least one of the relative value of the target amplitude drop, the area of the target waveform drop area, etc.
- the voltage difference in the reference index and the maximum The voltage ratio refers to the maximum value among the ratios of the voltage difference and the maximum voltage corresponding to each high-frequency QRS waveform data whose corresponding waveform category is the preset category.
- the target amplitude decrease relative value refers to each high-frequency QRS waveform data whose corresponding waveform category is the preset category.
- the target waveform drop area area refers to the sum of the waveform drop area areas corresponding to each high-frequency QRS waveform data whose corresponding waveform category is the preset category. , average or maximum value.
- the default category includes at least one of a first category (eg V-shaped), a second category (eg L-shaped) and a third category (eg U-shaped).
- the ratio of the voltage difference to the maximum voltage in the reference indicator refers to the maximum value among the ratios of the voltage difference to the maximum voltage corresponding to each high-frequency QRS waveform data of the corresponding waveform category L-type.
- the preset categories including V-shaped, U-shaped, and L-shaped as an example analyze whether the waveform category of each high-frequency QRS waveform data is V-shaped, U-shaped, or L-shaped, and filter the high-frequency QRS waveform data whose waveform category is V-shaped. , U-shaped high-frequency QRS waveform data and L-shaped high-frequency QRS waveform data.
- the reference index is determined based on the four filtered pieces of high-frequency QRS waveform data. For details, please refer to the method provided in one or more embodiments of this application. According to The four selected high-frequency QRS waveform data determine each reference index, which will not be described again here.
- determining the target amplitude reduction relative value based on the filtered high-frequency QRS waveform data includes: for each filtered high-frequency QRS waveform data, according to the corresponding third reference point and the fourth reference point.
- the root mean square voltage determines the second amplitude drop relative value; the maximum value among the second amplitude drop relative values corresponding to the filtered high-frequency QRS waveform data is determined as the target amplitude drop relative value.
- the second amplitude drop relative value is obtained by difference between the root mean square voltage of the third reference point and the root mean square voltage of the corresponding fourth reference point, and the second amplitude drop relative value is compared with the root mean square voltage of the third reference point.
- the ratio of the voltages serves as the second amplitude drop relative value. It can be understood that if the waveform type of the high-frequency QRS waveform data is V-shaped, the first reference point is selected as the fourth reference point, and the corresponding determined first amplitude decrease relative value is determined as the second amplitude decrease relative value. If the waveform type of the high-frequency QRS waveform data is U-shaped or L-shaped, select the point with the smallest root mean square voltage from the second reference waveform data as the fourth reference point.
- the relative value of the target amplitude decrease can reflect the coronary vessel responsiveness, and the two are negatively correlated.
- the vascular response ability can be determined based on the relative value of the target amplitude decrease. If the relative value of the target amplitude decrease is greater, the corresponding vascular response ability will be marked smaller or lower, indicating that the coronary vascular response ability is weaker. Therefore, based on the ratio of the voltage difference to the maximum voltage and the relative value of the target amplitude decrease, a more accurate vascular response capability can be obtained. Specifically, the vascular response capability can be determined based on the respective threshold intervals of the two.
- the ratio of the voltage difference to the maximum voltage and the relative value of the target amplitude drop are compared with their respective threshold intervals to determine the reference priority of the threshold interval as the reference priority of the corresponding reference index, and filter the reference priority.
- Higher-level reference metrics or dimensions are used to determine vascular responsiveness.
- determine the vascular response capabilities based on the ratio of the voltage difference to the maximum voltage and the threshold interval in which the relative value of the target amplitude decrease is located, and select the vascular response capabilities with higher priority as the final vascular response capabilities. It can be understood that if the ratio of the voltage difference to the maximum voltage and the relative value of the target amplitude decrease have the same reference priority, then any one of them is selected to determine the vascular response capability.
- four amplitude threshold intervals from the first amplitude threshold interval to the fourth amplitude threshold interval are preconfigured with the reference priority sequentially lowered, for example, they are: greater than or equal to 66%, greater than or equal to 60% and less than 66%, greater than or equal to 50% and less than 60%, greater than or equal to 40% and less than 50%, the corresponding reference priorities are recorded as the first level to the fourth level respectively.
- the reference priority of the target amplitude decrease relative value is determined to be the first level with the highest reference priority.
- the reference priority of the ratio of the voltage difference to the maximum voltage is determined as the second highest level. Since the target amplitude decreases, the reference priority (first level) of the relative value is higher than that of the ratio of the voltage difference to the maximum voltage. Referring to the priority level (second level), the vascular responsiveness is determined based on the amplitude threshold interval in which the relative value of the target amplitude decrease is, and since the relative value of the target amplitude decrease is in the first amplitude threshold interval, the vascular responsiveness is determined as a priority. The highest level of the first level.
- the vascular response ability is determined as the first level with the highest priority of attention. If the ratio of the voltage difference to the maximum voltage is in the second ratio threshold interval, the vascular response ability is determined as the first level. The second level with the second highest priority of attention is determined, and the second level with the higher priority of attention is selected as the final vascular responsiveness through comparison. Referring to the ratio of the voltage difference to the maximum voltage and the corresponding relationship between the vascular responsiveness, it can be seen that if the relative value of the target amplitude decrease is in the second amplitude threshold interval, the vascular responsiveness is determined to be the second level with the next highest priority, and so on. Not listed here.
- determining the target waveform falling area area based on the filtered high-frequency QRS waveform data includes: selecting a seventh reference point and an eighth reference point from the filtered high-frequency QRS waveform data; according to the seventh reference point The reference point, the eighth reference point and the high-frequency QRS waveform data determine the area of the waveform drop area; the sum, average or maximum value of the waveform drop area area corresponding to each filtered high-frequency QRS waveform data is determined as the target waveform drop. Area area.
- the point corresponding to the starting point of the movement phase in the high-frequency QRS waveform data is used as the seventh reference point, or the second reference point (or the third reference point) as the seventh reference point, and the point corresponding to the end point of the movement phase in the high-frequency QRS waveform data is used as the eighth reference point.
- the root mean square voltage of the seventh reference point is determined as the reference amplitude, and the closed area determined by the reference amplitude, the eighth reference point and the high-frequency QRS waveform data and below the reference amplitude is determined as the waveform drop area, through the first function Calculate the area of the closed area to obtain the absolute falling area, and use the absolute falling area as the waveform falling area area of the corresponding high-frequency QRS waveform data.
- the time of the seventh reference point is earlier than the time of the eighth reference point.
- the area of the target waveform decline area can be used to reflect the coronary vessel responsiveness, and the two are inversely related.
- the corresponding vascular responsiveness can be determined based on the area of the target waveform's declining area. If the area of the target waveform's declining area is larger, the corresponding vascular responsiveness will be marked as lower or smaller (the higher the priority of attention) to indicate the weaker the coronary vascular responsiveness. . Therefore, according to the ratio of the voltage difference to the maximum voltage and the area of the target waveform drop area, a more accurate vascular response capability can be obtained. Specifically, the vascular response capability can be determined based on the respective threshold intervals of the two.
- a total of three area thresholds from the first area threshold interval to the third area threshold interval with successively lower reference priorities are preconfigured.
- interval if the ratio of the voltage difference to the maximum voltage is in the first ratio threshold interval, and the area of the target waveform falling area is in the first area threshold interval, then the vascular response capability is marked as the first level. If the ratio of the voltage difference to the maximum voltage is in the Two ratio threshold intervals, and the area of the target waveform decline area is in the first area threshold interval, then the vascular response capability is marked as the second level, which will not be listed here.
- the area threshold interval preconfigured for the waveform falling area includes the preconfigured absolute area threshold interval for the absolute falling area, and/or, for the relative falling area Preconfigured relative area threshold intervals. Therefore, if the target waveform drop area is in the first area threshold interval, the target absolute drop area and/or the target relative drop area included in it are respectively in the corresponding area threshold interval in the first area threshold interval.
- more accurate vascular response capability can be obtained based on the ratio of the voltage difference to the maximum voltage, the area of the target waveform drop area, and the relative value of the target amplitude drop.
- multiple corresponding combination methods can be obtained based on the respective threshold intervals of each reference index. Referring to the vascular response capability determination method provided in one or more embodiments of the present application, according to various combinations of each reference index The method can obtain the corresponding vascular responsiveness, which will not be described again here.
- the vascular response capability is marked as Focus on the first level with the highest priority.
- the above-mentioned high-frequency QRS waveform data analysis method also includes: determining the number of positives based on the high-frequency QRS waveform data corresponding to the exercise ECG data; S118 includes: based on the voltage difference corresponding to the filtered high-frequency QRS waveform data.
- the ratio to the maximum voltage and the number of positives determine the vascular responsiveness; or, determine the reference index based on the screened high-frequency QRS waveform data, and determine the vascular responsiveness based on the reference index and the number of positives; the reference index includes the voltage difference and the maximum voltage
- the ratio also includes at least one of the relative value of the target amplitude drop and the area of the target waveform drop area.
- the corresponding lead positive indicators are determined based on each high-frequency QRS waveform data corresponding to the exercise ECG data, and the lead positive indicators indicating positive are screened and counted from each high-frequency QRS waveform data corresponding to the exercise ECG data.
- Use the high-frequency QRS waveform data to obtain the number of positives corresponding to the exercise ECG data.
- the reference index is determined based on the filtered high-frequency QRS waveform data, and the vascular response capability is determined based on the reference index and the number of positives.
- the absolute value of the second amplitude drop and the relative value of the second amplitude drop are determined based on the respective root mean square voltages of the third reference point and the fourth reference point. value, and determine the lead positive indicator of the corresponding high-frequency QRS waveform data based on the second relative amplitude decrease value and the second relative amplitude decrease value. If the absolute value of the second amplitude drop and the relative value of the second amplitude drop of the high-frequency QRS waveform data both meet the preset lead positivity conditions, the lead positivity indicator indicates that the corresponding electrocardiogram lead is positive.
- the preset lead positive conditions can be customized according to the actual detection situation, and can be adaptively adjusted according to the age, gender, height, weight and other factors of the subject.
- the absolute value of the second amplitude decrease is greater than 1uV and the second amplitude decreases.
- the relative value is greater than 50% and is not specifically limited here.
- the number of positives can be used to reflect the responsiveness of coronary vessels, and the two are inversely related.
- the responsiveness of the corresponding blood vessel can be determined based on the number of positives. If the number of positives is larger, the responsiveness of the corresponding blood vessel will be marked as lower or smaller (the higher the priority of attention) to indicate that the responsiveness of the coronary blood vessels is weaker. Therefore, according to the ratio of the voltage difference to the maximum voltage and the number of positives, a more accurate vascular responsiveness can be obtained. Specifically, the vascular responsiveness can be determined based on the threshold intervals in which the two are located.
- a total of four quantitative thresholds from the first quantitative threshold interval to the fourth quantitative threshold interval with successively lower reference priorities are preconfigured for the number of positives.
- the intervals are, for example, greater than or equal to 7, greater than or equal to 5 and less than 7, greater than or equal to 3 and less than 5, greater than or equal to 1 and less than 3. If the ratio of the voltage difference to the maximum voltage is in the first ratio threshold interval, And the number of positives is in the first quantitative threshold interval, then the vascular responsiveness is marked as the first level.
- the vascular responsiveness is marked It is the second level and will not be listed here. It can be understood that if the reference priority of the ratio threshold interval where the ratio of the voltage difference to the maximum voltage is located is higher, and the reference priority of the quantity threshold interval where the number of positives is located is lower, the priority of attention to the vascular responsiveness can be appropriately lowered. .
- vascular responsiveness based on the method of determining vascular responsiveness based on reference indicators provided in one or more embodiments of the present application, it can be seen that on the basis of the ratio of the voltage difference to the maximum voltage and the number of positives, it is also combined with the decrease in target amplitude At least one of the relative value and the area of the target waveform drop area can obtain more accurate vascular response capability.
- the specific combination method and the corresponding vascular response capability determination method can be referred to the records of the corresponding embodiments, which will not be described again here. .
- the target waveform drop area is in the first area threshold interval
- the target amplitude drop relative value is in the first amplitude threshold interval
- the ratio of the voltage difference to the maximum voltage is in the first Ratio threshold interval
- a high-frequency QRS waveform data analysis method is provided.
- the method specifically includes the following steps:
- S502 Obtain high-frequency QRS waveform data corresponding to the exercise ECG data.
- S504 Select the high-frequency QRS waveform data in the first time period as the first reference waveform data.
- S506 Determine the first reference point based on the point with the smallest root mean square voltage in the first reference waveform data, and determine the second reference point based on the point that is earlier than the first reference point and has the largest root mean square voltage.
- S508 Determine the first amplitude decrease relative value according to the respective root mean square voltages of the first reference point and the second reference point.
- S512 Select the point with the largest root mean square voltage from the high-frequency QRS waveform data in the second time period as the third reference point, and select the point with the smallest root mean square voltage later than the third reference point as the fourth reference point. Reference point.
- S514 Determine the voltage difference based on the root mean square voltages of the third reference point and the fourth reference point.
- S516 Select a fifth reference point that satisfies the filtering condition from the first reference waveform data; the time of the fifth reference point is later than the first reference point.
- S518 Determine the first amplitude rise relative value based on the respective root mean square voltages of the first reference point and the fifth reference point.
- S520 Screen the high-frequency QRS waveform data whose first relative value of amplitude decrease is greater than or equal to the first preset threshold, and whose first relative value of amplitude increase is greater than or equal to the second preset threshold.
- S522 Select second reference waveform data whose amplitude fluctuation is less than or equal to the preset fluctuation amplitude from the high-frequency QRS waveform data in the second time period.
- S524 Select the point with the maximum root mean square voltage from the high-frequency QRS waveform data in the third time period as the sixth reference point.
- S526 Determine the second amplitude rise relative value based on the respective root mean square voltages of the end point of the second reference waveform data and the sixth reference point.
- S528 Screen high frequencies whose first relative value of amplitude decrease is greater than or equal to the first preset threshold, whose second relative value of amplitude increase is less than the third preset threshold, and whose duration of the second reference waveform data is greater than or equal to the preset duration threshold. QRS waveform data.
- S530 Screen the first relative value of amplitude decrease greater than or equal to the first preset threshold, the second relative value of amplitude increase greater than or equal to the third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset duration threshold. High frequency QRS waveform data.
- the reference index includes the ratio of the voltage difference to the maximum voltage, and also includes the relative value of the target amplitude drop, and the area of the target waveform drop area. at least one of.
- S534 Determine the number of positives based on the high-frequency QRS waveform data corresponding to the exercise ECG data.
- S536 Determine the vascular response capability according to the ratio of the voltage difference corresponding to the filtered high-frequency QRS waveform data to the maximum voltage, and the number of positives.
- the reference index determines the reference index based on the screened high-frequency QRS waveform data, and determine the vascular response capability based on the reference index and the number of positives; the reference index includes the ratio of the voltage difference to the maximum voltage, and also includes the relative value of the target amplitude drop and the target waveform drop. At least one of the area areas.
- the waveform category of each piece of high-frequency QRS waveform data is a preset category (such as the first category, the second category, or the third category), and the waveform categories are filtered into the first category, the second category, and the third category.
- Category high-frequency QRS waveform data used to determine reference indicators including the ratio of voltage difference to maximum voltage, and also including at least one of the relative value of the target amplitude drop and the area of the target waveform drop area, to determine the vascular response capability based on the reference indicators , or determine the number of positives based on the high-frequency QRS waveform data corresponding to the exercise ECG data, and determine the vascular response capability based on the number of positives, the ratio of the voltage difference to the maximum voltage (or, reference index), so as to accurately evaluate the blood vessels through non-invasive methods
- the response capability is for doctors’ reference, so that they can accurately identify the heart health status of the test subject based on clinical symptoms.
- a high-frequency QRS waveform data analysis device 600 including: an acquisition module 601, a selection module 602, an indicator determination module 603, and a screening module 604, wherein:
- the acquisition module 601 is used to acquire the high-frequency QRS waveform data corresponding to the exercise ECG data;
- the selection module 602 is used to select the high-frequency QRS waveform data in the first time period as the first reference waveform data;
- the selection module 602 is also configured to select the point with the smallest root mean square voltage in the first reference waveform data to determine the first reference point, and determine the second reference point with the point that is earlier than the first reference point and has the largest root mean square voltage. ;
- the indicator determination module 603 is used to determine the first amplitude drop relative value according to the respective root mean square voltages of the first reference point and the second reference point;
- the indicator determination module 603 is also used to determine the maximum voltage based on the high-frequency QRS waveform data
- the selection module 602 is used to select the point with the largest root mean square voltage as the third reference point from the high-frequency QRS waveform data in the second time period, and the point with the smallest root mean square voltage that is later than the third reference point. point as the fourth reference point;
- the index determination module 603 is also used to determine the voltage difference based on the root mean square voltages of the third reference point and the fourth reference point;
- the screening module 604 is used to screen high-frequency QRS waveform data whose first relative amplitude drop value is greater than or equal to the first preset threshold;
- the index determination module 603 is used to determine the vascular response capability based on the ratio of the voltage difference corresponding to the filtered high-frequency QRS waveform data and the maximum voltage.
- the filtering module 604 is also used to filter high-frequency QRS waveform data whose corresponding waveform categories are the first category, the second category, and the third category;
- the waveform characteristics of the first category include: the first amplitude decrease relative value is greater than or equal to the first preset threshold, and the first relative value of amplitude increase is greater than or equal to the second preset threshold;
- the waveform characteristics of the second category include: the first relative value of amplitude decrease is greater than or equal to the first preset threshold, the second The relative value of the amplitude increase is less than the third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset duration threshold;
- the third category of waveform characteristics includes: the first relative value of the amplitude decrease is greater than or equal to the first preset threshold.
- the second amplitude rise relative value is greater than or equal to the third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset duration threshold;
- the selection module 602 is also used to select from the first reference waveform data that satisfies the filtering The fifth reference point of the condition; the time of the fifth reference point is later than the first reference point;
- the index determination module 603 is also used to determine the first amplitude rise relative to each other based on the root mean square voltage of the first reference point and the fifth reference point.
- the selection module 602 is also used to select second reference waveform data whose amplitude fluctuation amplitude is less than or equal to the preset fluctuation amplitude from the high-frequency QRS waveform data in the second time period; from the high-frequency QRS waveform data in the third time period Select the point with the maximum root mean square voltage in the high-frequency QRS waveform data as the sixth reference point; the index determination module 603 is also used to determine the third reference point based on the respective root mean square voltages of the end point of the second reference waveform data and the sixth reference point. The relative value of the two amplitude rises.
- the filtering module 604 is also used to filter high-frequency QRS waveform data whose corresponding waveform category is the first category; or, filter high-frequency QRS waveform data whose corresponding waveform category is the second category; or, filter corresponding waveforms.
- the category is high-frequency QRS waveform data of the third category; the waveform characteristics of the first category include: the first relative amplitude decrease value is greater than or equal to the first preset threshold, and the first amplitude increase relative value is greater than or equal to the second preset threshold value.
- the waveform characteristics of the second category include: the first relative value of amplitude decrease is greater than or equal to the first preset threshold, the second relative value of amplitude increase is less than the third preset threshold, and the duration of the second reference waveform data is greater than or equal to the preset threshold.
- the waveform characteristics of the third category include: the first relative amplitude decrease value is greater than or equal to the first preset threshold, the second amplitude increase relative value is greater than or equal to the third preset threshold value, and the duration of the second reference waveform data The duration is greater than or equal to the preset duration threshold; the selection module 602 is also used to select the fifth reference point that meets the filtering conditions from the first reference waveform data; the time of the fifth reference point is later than the first reference point; the indicator determination module 603 , is also used to determine the first amplitude rise relative value based on the respective root mean square voltages of the first reference point and the fifth reference point; the selection module 602 is also used to select from the high-frequency QRS waveform data in the second time period, Select the second reference waveform data whose amplitude fluctuation is less than or equal to the preset fluctuation amplitude; select the point with the maximum root mean square voltage from the high-frequency QRS waveform data in the third time period as the sixth reference point; indicator
- the indicator determination module 603 is also used to determine reference indicators based on the filtered high-frequency QRS waveform data; the reference indicators include the ratio of the voltage difference to the maximum voltage, and also include the relative value of the target amplitude drop, the target waveform drop At least one of the following: regional area; determines vascular responsiveness based on a reference metric.
- the indicator determination module 603 is also used to determine the number of positives based on the high-frequency QRS waveform data corresponding to the exercise ECG data; based on the ratio of the voltage difference corresponding to the filtered high-frequency QRS waveform data to the maximum voltage, and the number of positives to determine the vascular responsiveness; or, determine the reference index based on the screened high-frequency QRS waveform data, and determine the vascular responsiveness based on the reference index and the number of positives; the reference index includes the ratio of the voltage difference to the maximum voltage, and also includes the target At least one of the relative amplitude drop value and the target waveform drop area area.
- Each module in the above-mentioned high-frequency QRS waveform data analysis device can be implemented in whole or in part by software, hardware, and combinations thereof.
- Each of the above modules may be embedded in or independent of the processor of the computer device in the form of hardware, or may be stored in the memory of the computer device in the form of software, so that the processor can call and execute the operations corresponding to the above modules.
- a computer device is provided.
- the computer device may be a server, and its internal structure diagram may be as shown in Figure 7 .
- the computer device includes a processor, memory, and network interfaces connected through a system bus.
- the computer device's processor is used to provide computing and control capabilities.
- the memory of the computer device includes non-volatile storage media and internal memory.
- the non-volatile storage medium stores an operating system, computer-readable instructions and a database.
- This internal memory provides an environment for the execution of an operating system and computer-readable instructions in a non-volatile storage medium.
- the database of the computer device is used to store high-frequency QRS waveform data corresponding to the exercise ECG data.
- the network interface of the computer device is used to communicate with external terminals through a network connection.
- the computer-readable instructions when executed by the processor, implement a high-frequency QRS waveform data analysis method.
- Figure 7 is only a block diagram of a partial structure related to the solution of the present application, and does not constitute a limitation on the computer equipment to which the solution of the present application is applied.
- Specific computer equipment can May include more or fewer parts than shown, or combine certain parts, or have a different arrangement of parts.
- a computer device including a memory and a processor.
- the memory stores computer-readable instructions.
- the processor executes the computer-readable instructions, it implements the steps in each method embodiment.
- a computer-readable storage medium is provided with computer-readable instructions stored thereon, and when executed by a processor, the computer-readable instructions implement the steps in each method embodiment.
- Non-volatile memory may include read-only memory (ROM), magnetic tape, floppy disk, flash memory or optical memory, etc.
- Volatile memory may include random access memory (RAM) or external cache memory.
- RAM can be in various forms, such as static random access memory (Static Random Access Memory, SRAM) or dynamic random access memory (Dynamic Random Access Memory, DRAM).
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Abstract
一种高频QRS波形数据分析方法、装置、计算机设备和存储介质。高频QRS波形数据分析方法包括:获取高频QRS波形数据;选取在第一时间段内的第一参考波形数据;根据第一参考波形数据中均方根电压最小的点确定第一参考点,以及时间早于第一参考点、且均方根电压最大的点确定第二参考点(S106);根据第一参考点与第二参考点确定第一振幅下降相对值;根据高频QRS波形数据确定最大电压(S110);从第二时间段内选取均方根电压最大的第三参考点,及时间晚于第三参考点、且均方根电压最小的第四参考点;根据第三参考点与第四参考点确定电压差;筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据(S116),根据相应电压差与最大电压的比值确定血管响应能力。
Description
本申请要求于2022年6月21日提交中国专利局,申请号为2022107056854 ,申请名称为“高频QRS波形数据分析方法、装置、计算机设备与存储介质”的中国专利申请的优先权,其全部内容通过引用结合在本申请中。
本申请涉及医疗仪器技术领域,特别是涉及一种高频QRS波形数据分析方法、装置、计算机设备与存储介质。
冠状动脉血管响应能力可简称为冠脉血管响应能力或血管响应能力,其能够用于表征血管对于供血快速扩张的即时反应能力,且能够作为评估心肌细胞的活力状态的指标之一提供给医生参考,以便于医生结合临床症状等准确识别受测者的心脏健康状况。由此,如何准确评估血管响应能力是值得关注的问题。
目前,通常通过冠脉造影等有创方式来评估冠脉血管响应能力,但是,发明人意识到,该种有创方式会对受测者的身体健康产生或多或少的影响,也存在通过分析心电图(ECG)中ST-T段的改变来评估冠脉血管响应能力,该种无创方式虽然不会对受测者的身体健康产生负面影响,但是评估准确性低,由此存在无创无损与准确性不能兼顾的问题。
根据本申请公开的各种实施例,提供一种高频QRS波形数据分析方法、装置、计算机设备与存储介质。
一种高频QRS波形数据分析方法,所述方法包括:
获取运动心电数据对应的高频QRS波形数据;
选取在第一时间段内的高频QRS波形数据作为第一参考波形数据;
根据所述第一参考波形数据中均方根电压最小的点确定第一参考点,以及时间早于所述第一参考点、且均方根电压最大的点确定第二参考点;
根据所述第一参考点与所述第二参考点各自的均方根电压确定第一振幅下降相对值;
根据所述高频QRS波形数据确定最大电压;
从在第二时间段内的高频QRS波形数据中选取均方根电压最大的点作为第三参考点,以及时间晚于所述第三参考点、且均方根电压最小的点作为第四参考点;
根据所述第三参考点与所述第四参考点各自的均方根电压确定电压差;
筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据;
根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力。
在其中一个实施例中,所述筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据,包括:
筛选相应波形类别为第一类别、第二类别与第三类别的高频QRS波形数据;
所述第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;
所述第二类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;
所述第三类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值大于或等于所述第三预设阈值、且第二参考波形数据的持续时长大于或等于所述预设时长阈值;
所述第一振幅上升相对值的确定步骤,包括:
从所述第一参考波形数据中选取满足筛选条件的第五参考点;所述第五参考点的时间晚于所述第一参考点;
基于所述第一参考点与所述第五参考点各自的均方根电压确定第一振幅上升相对值;
所述第二振幅上升相对值的确定步骤,包括:
从在所述第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;
从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;
基于所述第二参考波形数据的结束点与所述第六参考点各自的均方根电压确定第二振幅上升相对值。
在其中一个实施例中,所述筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据,包括:
筛选相应波形类别为第一类别的高频QRS波形数据;或,筛选相应波形类别为第二类别的高频QRS波形数据;或,筛选相应波形类别为第三类别的高频QRS波形数据;
所述第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;
所述第二类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;
所述第三类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值大于或等于所述第三预设阈值、且第二参考波形数据的持续时长大于或等于所述预设时长阈值;
所述第一振幅上升相对值的确定步骤,包括:
从所述第一参考波形数据中选取满足筛选条件的第五参考点;所述第五参考点的时间晚于所述第一参考点;
基于所述第一参考点与所述第五参考点各自的均方根电压确定第一振幅上升相对值;
所述第二振幅上升相对值的确定步骤,包括:
从在所述第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;
从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;
基于所述第二参考波形数据的结束点与所述第六参考点各自的均方根电压确定第二振幅上升相对值。
在其中一个实施例中,所述根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力,包括:
根据所筛选出的高频QRS波形数据确定参考指标;所述参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项;
根据所述参考指标确定血管响应能力。
在其中一个实施例中,所述方法还包括:
根据所述运动心电数据对应的高频QRS波形数据确定阳性数量;
所述根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力,包括:
根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值,以及所述阳性数量确定血管响应能力;或,
根据所筛选出的高频QRS波形数据确定参考指标,并根据所述参考指标与所述阳性数量确定血管响应能力;所述参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项。
一种高频QRS波形数据分析装置,所述装置包括:
获取模块,用于获取运动心电数据对应的高频QRS波形数据;
选取模块,用于选取在第一时间段内的高频QRS波形数据作为第一参考波形数据;
所述选取模块,还用于根据所述第一参考波形数据中均方根电压最小的点确定第一参考点,以及时间早于所述第一参考点、且均方根电压最大的点确定第二参考点;
指标确定模块,用于根据所述第一参考点与所述第二参考点各自的均方根电压确定第一振幅下降相对值;
所述指标确定模块,还用于根据所述高频QRS波形数据确定最大电压;
所述选取模块,用于从在第二时间段内的高频QRS波形数据中选取均方根电压最大的点作为第三参考点,以及时间晚于所述第三参考点、且均方根电压最小的点作为第四参考点;
所述指标确定模块,还用于根据所述第三参考点与所述第四参考点各自的均方根电压确定电压差;
筛选模块,用于筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据;
指标确定模块,用于根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力。
在其中一个实施例中,所述筛选模块,还用于筛选相应波形类别为第一类别、第二类别与第三类别的高频QRS波形数据;所述第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;所述第二类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;所述第三类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值大于或等于所述第三预设阈值、且第二参考波形数据的持续时长大于或等于所述预设时长阈值;
所述选取模块,还用于从所述第一参考波形数据中选取满足筛选条件的第五参考点;所述第五参考点的时间晚于所述第一参考点;
所述指标确定模块,还用于基于所述第一参考点与所述第五参考点各自的均方根电压确定第一振幅上升相对值;
所述选取模块,还用于从在所述第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;
所述指标确定模块,还用于基于所述第二参考波形数据的结束点与所述第六参考点各自的均方根电压确定第二振幅上升相对值。
在其中一个实施例中,所述筛选模块,还用于筛选相应波形类别为第一类别的高频QRS波形数据;或,筛选相应波形类别为第二类别的高频QRS波形数据;或,筛选相应波形类别为第三类别的高频QRS波形数据;所述第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;所述第二类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;所述第三类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值大于或等于所述第三预设阈值、且第二参考波形数据的持续时长大于或等于所述预设时长阈值;
所述选取模块,还用于从所述第一参考波形数据中选取满足筛选条件的第五参考点;所述第五参考点的时间晚于所述第一参考点;
所述指标确定模块,还用于基于所述第一参考点与所述第五参考点各自的均方根电压确定第一振幅上升相对值;
所述选取模块,还用于从在所述第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;
所述指标确定模块,还用于基于所述第二参考波形数据的结束点与所述第六参考点各自的均方根电压确定第二振幅上升相对值。
在其中一个实施例中,所述指标确定模块,还用于根据所筛选出的高频QRS波形数据确定参考指标;所述参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项;根据所述参考指标确定血管响应能力。
在其中一个实施例中,所述指标确定模块,还用于根据所述运动心电数据对应的高频QRS波形数据确定阳性数量;根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值,以及所述阳性数量确定血管响应能力;或,根据所筛选出的高频QRS波形数据确定参考指标,并根据所述参考指标与所述阳性数量确定血管响应能力;所述参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项。
一种计算机设备,包括存储器和处理器,所述存储器存储有计算机可读指令,所述处理器执行所述计算机可读指令时实现各方法实施例中的步骤。
一种计算机可读存储介质,其上存储有计算机可读指令,所述计算机可读指令被处理器执行时实现各方法实施例中的步骤。
本申请的一个或多个实施例的细节在下面的附图和描述中提出。本申请的其它特征和优点将从说明书、附图以及权利要求书变得明显。
为了更清楚地说明本申请实施例中的技术方案,下面将对实施例中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本申请的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其它的附图。
图1为根据一个或多个实施例中高频QRS波形数据分析方法的流程示意图。
图2为根据一个或多个实施例中基于高频QRS波形数据选取各参考点的示意图。
图3为根据一个或多个实施例中基于高频QRS波形数据选取各参考点与参考波形数据的示意图。
图4为另一个实施例中基于高频QRS波形数据选取各参考点与参考波形数据的示意图。
图5为另一个实施例中高频QRS波形数据分析方法的流程示意图。
图6为根据一个或多个实施例中高频QRS波形数据分析装置的结构框图。
图7为根据一个或多个实施例中计算机设备的内部结构图。
为了使本申请的技术方案及优点更加清楚明白,以下结合附图及实施例,对本申请进行进一步详细说明。应当理解,此处描述的具体实施例仅仅用以解释本申请,并不用于限定本申请。
本申请提供的高频QRS波形数据分析方法,可以应用于终端,也可以应用于服务器,还可以应用于包括终端与服务器的交互系统,并通过终端和服务器的交互实现,在此不作具体限定。终端可以但不限于是各种个人计算机、笔记本电脑、智能手机、平板电脑、心电监测设备和便携式可穿戴设备,服务器可以用独立的服务器或者是多个服务器组成的服务器集群来实现。
在一些实施例中,如图1所示,提供了一种高频QRS波形数据分析方法,以该方法应用于服务器为例进行说明,具体包括以下步骤:
S102,获取运动心电数据对应的高频QRS波形数据。
运动心电数据是指在负荷运动心电检测过程中采集到的心电数据。负荷运动心电检测是通过一定量的运动增加心脏负荷,以采集受测者的心电数据,以便于基于所采集到的心电数据分析分析受测者的心脏健康状况的心电检测方式,其被广泛应用于心脏疾病与心血管疾病的检测。运动心电数据中包括多个反映左、右心室除极电位和时间的变化的QRS波群,每个QRS波群为心电图中Q波、R波和S波的集合。基于运动心电数据中的QRS波群能够分析得到相应高频QRS波形数据,高频QRS波形数据与高频QRS波形曲线相对应,高频QRS波形数据包括高频QRS波形曲线上各点的数据(如时间与均方根电压),由此,基于高频QRS波形数据能够确定相应高频QRS波形曲线。高频QRS波形数据/高频QRS波形曲线用于表征在整个负荷运动心电检测过程中,受测者的QRS波群高频成分的均方根电压随时间的变化趋势,也即是用于体现整个负荷运动心电检测过程中的能量变化趋势。高频QRS波形数据通过高频QRS波形图呈现,在高频QRS波形图中,横坐标是时间,对应负荷运动心电检测过程的检测时间,单位是min(分钟),纵坐标是均方根电压(RMS电压),均方根电压也可以理解为强度或振幅,单位是uV(微伏)。
具体地,获取受测者在整个负荷运动心电检测过程中对应的运动心电数据,分析运动心电数据中QRS波群的高频成分得到相应高频QRS波形数据。运动心电数据包括受测者在整个负荷运动心电检测过程中各次心跳对应的ECG(心电图),ECG中包括QRS波群。通过窗口函数按照时序与预设移动步长将运动心电数据划分为多个心电数据子集,每个心电数据子集包括多次心跳对应的ECG。对于每个心电数据子集,对其所包括的多次心跳对应的ECG或QRS波群,依次进行对齐、求平均与带通滤波处理得到相应高频QRS波群(QRS波群的高频波段),对该高频QRS波群求均方根得到相应均方根电压,作为该心电数据子集对应的均方根电压/强度/振幅。根据各心电数据子集对应的均方根电压与相应时间得到相应高频QRS波形数据,以便于按照时序对高频QRS波形数据中的各均方根电压进行曲线平滑处理,得到相应高频QRS波形曲线。或者,按照时序对各心电数据子集对应的均方根电压进行曲线平滑处理,得到相应高频QRS波形曲线,并根据高频QRS波形曲线上各点的时间与均方根电压得到相应高频QRS波形数据。
可以理解,窗口函数的窗口长度与预设移动步长均可根据实际需求自定义,比如,窗口长度设置为10秒,预设移动步长设置为10秒或一次心跳周期,一次心跳周期是指相邻两次心跳之间的时间间隔,在此不作具体限定。按照时序是指按照信号的采集时间/负荷运动心电检测过程推进的检测时间的先后顺序。
在一些实施例中,负荷运动心电检测过程包括多个阶段,具体可依次包括静息阶段、运动阶段和恢复阶段等三个阶段,运动心电数据包括各阶段的心电数据。可以理解,阶段的划分不限于此,具体可根据实际情况进行划分。
在一些实施例中,在负荷运动心电检测过程中,可采用10个分布在人体的胸部和四肢的电极片,形成12条心电图导联(如V1、V2、V3、V4、V5、V6、Ⅰ、Ⅱ、Ⅲ、aVL、aVF和aVR),对应输出12组心电数据,得到整个负荷运动心电检测过程对应的运动心电数据。可以理解,10个电极片仅作为示例,并不用于具体限定电极片的个数,具体可根据实际需求动态确定,比如更多或更少数量的电极片。由此,运动心电数据包括至少一条心电图导联对应的心电数据,通过分别分析每条心电图导联对应的心电数据中的QRS波群高频成分,得到每条心电图导联对应的高频QRS波形数据。
S104,选取在第一时间段内的高频QRS波形数据作为第一参考波形数据。
第一时间段可以是由预设的起始时间点与结束时间点确定的时间区间,也可以是由预设的起始时间点与预设时长确定的时间区间。第一时间段具体可包括运动前一段时间与运动中的一段时间,或者,包括运动中的一段时间,运动前一段时间位于静息阶段,运动中的一段时间位于运动阶段,如运动开始后的一段时间。以运动阶段在高频QRS波形曲线中对应的时间范围为3至9分钟为例,第一时间段比如为[1分钟20秒,6分钟]所表征的时间区间,该第一时间段包括运动前的100秒、运动中的前3分钟,第一时间段还比如为 [3分钟,6分钟]所表征的时间区间,该第一时间段包括运动中的前3分钟。可以理解,上述举例仅用于示例,并不用于具体限定。第一参考波形数据是高频QRS波形数据中时间处于第一时间段内的数据,第一参考波形数据中各点的时间均处于第一时间段内,第一参考波形数据的起始点与结束点各自的时间,分别为该第一时间段的起始时间点与结束时间点。第一参考波形数据的起始点,是指第一参考波形数据中时间最早的点,也即是指按照时序排序时第一参考波形数据中的第一个点。结束点的定义类似,在此不再赘述。
S106,根据第一参考波形数据中均方根电压最小的点确定第一参考点,以及时间早于第一参考点、且均方根电压最大的点确定第二参考点。
具体地,第一参考波形数据中各个点的位置由该点的时间与均方根电压确定,按照时序遍历第一参考波形数据中各点的均方根电压,基于遍历的均方根电压从第一参考波形数据中筛选均方根电压最小的点,根据该均方根电压最小的点确定第一参考点,以及从第一参考波形数据中筛选时间早于/小于第一参考点的时间、且均方根电压最大的点,并根据该均方根电压最大的点确定第二参考点。
在一些实施例中,将所筛选出的均方根电压最小的点作为第一参考点,或者,根据预配置的第一修正系数对该均方根电压最小的点进行修正,并将通过修正得到的点作为第一参考点。将所筛选出的时间早于第一参考点、且均方根电压最大的点作为第二参考点,或者,根据预配置的第二修正系数对该均方根电压最大的点进行修正,并将修正得到的点作为第二参考点。
具体地,由预配置的第一修正系数修正该均方根电压最小的点所对应的均方根电压,得到修正后的均方根电压,将第一参考波形数据中均方根电压与该修正后的均方根电压一致的点选作为第一参考点。类似地,基于第二修正系数与所筛选出的均方根电压最大的点确定第二参考点,在此不再赘述。可以理解,若第一参考波形数据中均方根电压与修正后的均方根电压一致的点有多个,可任选其一作为相应参考点,但需满足第二参考点的时间早于第一参考点的时间这一约束条件。第一修正系数与第二修正系数具体可自定义,也可根据受测者的用户画像动态确定,具体可以是基于用户画像确定的函数,第一修正系数大于1,第二修正系数小于1。用户画像包括受测者的年龄、性别、体重、临床症状、生活习惯等中的至少一项。
S108,根据第一参考点与第二参考点各自的均方根电压确定第一振幅下降相对值。
具体地,基于第一参考波形数据分别获取第一参考点与第二参考点各自的均方根电压,将第二参考点的均方根电压与第一参考点的均方根电压作差得到第一振幅下降绝对值,将第一振幅下降绝对值与第二参考点的均方根电压的比值确定为第一振幅下降相对值。
S110,根据高频QRS波形数据确定最大电压。
最大电压可理解为最大功率,能够用于体现受测者的最大心脏泵血功能。具体地,从高频QRS波形数据中获取均方根电压的最大值作为目标电压,根据该目标电压确定相应最大电压。可将目标电压确定为最大电压,也可通过预配置的第三修正系数修正目标电压得到最大电压。第三修正系数根据实际情况自定义,比如,若将第三修正系数与目标电压的和值作为最大电压,则第三修正系数可设置为1uV(微伏),若将第三修正系数与目标电压的乘积作为最大电压,则第三修正系数可设置为1.2。可以理解,还可对目标电压或由第三修正系数修正后的目标电压进行向上取整得到最大电压,比如,若目标电压或由第三修正系数修正后的目标电压为9.6uV,则通过向上取整操作可将最大电压确定为10 uV。第三修正系数及目标电压的修正方式在此不作具体限定。
在一些实施例中,对于单个受测者,若心电图导联为一条,则从该条心电图导联对应的高频QRS波形数据中获取均方根电压的最大值作为目标电压。若心电图导联多于一条(有多条),则从各条心电图导联对应的高频QRS波形数据中分别获取均方根电压的最大值,比较各均方根电压的最大值,并基于比较从中筛选最大的均方根电压作为目标电压。这样,基于目标电压确定最大电压。
在一些实施例中,每条心电图导联对应的高频QRS波形数据中不仅包括相应高频QRS波形曲线上各点的数据,还包括按照本申请的一个或多个实施例所确定的最大电压。
S112,从在第二时间段内的高频QRS波形数据中选取均方根电压最大的点作为第三参考点,以及时间晚于第三参考点、且均方根电压最小的点作为第四参考点。
第二时间段具体可包括运动前一段时间、运动中和运动后一段时间,运动前一段时间位于静息阶段,运动中包括整个运动阶段,运动后一段时间位于恢复阶段,运动前一段时间、运动中与运动后一段时间是依次连续的时间段。以运动阶段在高频QRS波形数据中对应的时间范围为3至9分钟为例,第二时间段比如为[1分钟20秒,9分钟20秒]所表征的时间区间,其以时间点1分钟20秒为起始时间点、且以时间点9分钟20秒为结束时间点,该第二时间段包括运动前的100秒、运动中的6分钟与运动后的20秒。第二时间段包括第一时间段,第二时间段的起始时间点可与第一时间段的起始时间点相同。
具体地,遍历高频QRS波形数据中在第二时间段内各点的均方根电压,基于遍历的均方根电压,从在第二时间段内的高频QRS波形数据中筛选均方根电压最大的点作为第三参考点,以及时间晚于/大于第三参考点的时间、且均方根电压最小的点作为第四参考点。
在一些实施例中,第三参考点与第二参考点可能为同一个点,具体由相应高频QRS波形数据确定。若在第二时间段内的高频QRS波形数据中均方根电压最大的点有多个,从该多个均方根电压最大的点中筛选时间最早的点作为第三参考点。
S114,根据第三参考点与第四参考点各自的均方根电压确定电压差。
具体地,将第三参考点的均方根电压与相应第四参考点的均方根电压作差,得到相应高频QRS波形数据所对应的电压差。可以理解,电压差可理解为振幅下降绝对值,具体可以是本申请中一个或多个实施例中的第二振幅下降绝对值。
在一些实施例中,图2提供了基于高频QRS波形数据选取各参考点的示意图。如图2所示,高频QRS波形图中显示有基于心电图导联Ⅱ对应的高频QRS波形数据所确定的高频QRS波形曲线,横坐标为时间,单位为分钟,纵坐标为均方根电压/振幅,单位为微伏,运动阶段在该高频QRS波形数据中对应的时间范围为0至6分钟,第一时间段为[0之前100秒,3分钟]对应的时间区间,第二时间段为[0之前100秒,6分钟20秒]对应的时间区间,第一参考波形数据包括高频QRS波形数据中处于第一时间段内的数据,第一参考点为第一参考波形数据中均方根电压最小的点,第二参考点为第一参考波形数据中时间早于第一参考点、且均方根电压最大的点,第三参考点为第二时间段内均方根电压最大的点,第四参考点为第二时间段内时间晚于第三参考点、且均方根电压最小的点。在本实施例中,第三参考点与第二参考点为同一个点,第四参考点与第一参考点为同一个点,最大电压为12uV(高频QRS波形图中所呈现/显示的纵坐标的最大值),基于第三参考点与第四参考点确定的电压差(第二振幅下降绝对值)为4.8uV,第二振幅下降相对值为53%。可以理解,图2所示的高频QRS波形数据及对应选取的各参考点,以及第一参考点与第二参考点的选取仅作为示例,并不用于具体限定。
S116,筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据。
第一预设阈值可根据经验值自定义,如自定义为40%,也可根据受测者的用户画像动态确定,用户画像包括年龄、体重、性别与负荷等级等参数中的至少一项,在此不作具体限定。
具体地,对于单个受测者,从运动心电数据对应的各高频QRS波形数据中筛选相应第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据,以便于基于所筛选出的高频QRS波形数据确定血管响应能力。
在一些实施例中,若第一时间段包括运动前一段时间与运动中的一段时间,则筛选第一振幅下降相对值大于或等于第一预设阈值、且第一参考点与第二参考点之间的时间间隔小于或等于预设时间间隔的高频QRS波形数据,以便于基于所筛选出的高频QRS波形数据确定电压差与最大电压的比值,或者,包括电压差与最大电压的比值的参考指标,用于进一步确定血管响应能力。预设时间间隔可根据实际情况自定义,比如3分钟。
在一些实施例中,若运动心电数据对应的各高频QRS波形数据所对应的第一振幅下降相对值均小于第一预设阈值,则无需进一步确定相应血管响应能力,而输出各高频QRS波形数据供医生参考。可以理解,在确定并输出血管响应能力的情况下,也可同步输出各高频QRS波形数据供医生参考。
S118,根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力。
血管响应能力用于表征冠脉血管响应能力的不同,以供医生参考,以便于医生根据血管响应能力与临床症状能够准确识别心脏健康状况,从而给出进一步的诊疗或检测参考建议。
具体地,对于所筛选出的每条高频QRS波形数据,基于相应电压差与最大电压能够确定电压差与最大电压的比值。进一步地,根据所筛选出的各高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力。
在一些实施例中,从所筛选出的各高频QRS波形数据对应的电压差与最大电压的比值中,筛选电压差与最大电压的比值的最大值,并根据所筛选出的电压差与最大电压的比值确定血管响应能力。举例说明,若所筛选出的三条高频QRS波形数据各自对应的电压差与最大电压的比值分别为16%、40%与52%,则根据52%(电压差与最大电压的比值的最大值)确定血管响应能力。可以理解,可将所筛选出的电压差与最大电压的比值的最大值理解为电压差与最大电压的目标比值。
在一些实施例中,可在筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据之前,针对运动心电数据对应的每条高频QRS波形数据分别确定相应电压差与最大电压。也可在筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据之后,针对所筛选出的每条高频QRS波形数据分别确定相应电压差与最大电压。可以理解,对于单条高频QRS波形数据,具体可参照本申请的一个或多个实施例中提供的方式,确定相应电压差与最大电压,以便于基于电压差与最大电压确定该高频QRS波形数据所对应的电压差与最大电压的比值。
在一些实施例中,电压差与最大电压的比值能够反应冠脉血管响应能力,二者成负相关关系。由此,基于电压差与最大电压的比值能够确定相应血管响应能力,如电压差与最大电压的比值越大,则标注相应血管响应能力越低或越小(关注优先级越高),以表征冠脉血管响应能力越弱。具体可根据电压差与最大电压的比值所处的比值阈值区间确定相应血管响应能力。基于本申请的一个或多个实施例中提供的电压差与最大电压的比值的确定方式可知,电压差与最大电压的比值与受测者的个体差异性相关,由此,基于该比值能够准确评估得到受测者的血管响应能力。
举例说明,预配置有参考优先级依次降低的第一比值阈值区间至第四比值阈值区间共四个比值阈值区间,比如分别为:大于或等于46%、大于或等于40%且小于46%、大于或等于30%且小于40%、大于或等于16%且小于30%,若电压差与最大电压的比值处于第一比值阈值区间,则标注血管响应能力为关注优先级最高的第一级,若电压差与最大电压的比值处于第二比值阈值区间,则标注血管响应能力为关注优先级次高的第二级,依此类推,在此不一一列举。可以理解,若电压差与最大电压的比值不处于任一比值阈值区间(比如小于16%),可以标注血管响应能力为关注优先级最低的级别,也可不执行基于电压差与最大电压的比值确定进一步确定血管响应能力的相关操作,还可基于本申请提供的其他参考指标确定血管响应能力。
在一些实施例中,在筛选出第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据后,根据所筛选出的各高频QRS波形数据确定参考指标,并根据参考指标确定血管响应能力。参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项。可以理解,还可根据运动心电数据对应的各高频QRS波形数据确定阳性数量,并根据阳性数量与参考指标(电压差与最大电压的比值)确定血管响应能力。
可以理解,在本申请的一个或多个实施例中,若不考虑高频QRS波形数据对应的波形类别,参考指标中的电压差与最大电压的比值,是指相应第一振幅下降相对值大于或等于第一预设阈值的各高频QRS波形数据所对应的电压差与最大电压的比值中的最大值,目标振幅下降相对值是指相应第一振幅下降相对值大于或等于第一预设阈值的各高频QRS波形数据所对应的第二振幅下降相对值中的最大值,目标波形下降区域面积是指相应第一振幅下降相对值大于或等于第一预设阈值的各高频QRS波形数据所对应的波形下降区域面积的和值、平均值或最大值。
上述高频QRS波形数据分析方法,通过分析运动心电数据对应的高频QRS波形数据,选取处于第一时间段内的两个特征点分别作为第一参考点与第二参考点,以及选取处于第二时间段内的两个特征点分别作为第三参考点与第四参考点,并确定相应最大电压,基于第一参考点与第二参考点量化高频QRS波形数据在第一时间段内的波形变化情况得到第一振幅下降相对值,基于第三参考点与第四参考点量化得到表征振幅下降程度的电压差,在判定第一振幅下降相对值大于或等于第一预设阈值时,表征高频QRS波形数据的波形变化情况符合要求,则根据电压差与最大电压的比值评估得到准确性较高的血管响应能力,由此,能够通过无创方式准确评估受测者的冠脉血管响应能力,进一步地,还可将准确性较高的血管响应能力提供给医生参考,以便于医生结合临床症状准确识别受测者的心脏健康状况。
在一些实施例中,S116包括:筛选相应波形类别为第一类别、第二类别与第三类别的高频QRS波形数据;第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;第二类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;第三类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值大于或等于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;第一振幅上升相对值的确定步骤,包括:从第一参考波形数据中选取满足筛选条件的第五参考点;第五参考点的时间晚于第一参考点;基于第一参考点与第五参考点各自的均方根电压确定第一振幅上升相对值;第二振幅上升相对值的确定步骤,包括:从在第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;基于第二参考波形数据的结束点与第六参考点各自的均方根电压确定第二振幅上升相对值。
第一类别包括V型,第二类别包括L型,第三类别包括U型。筛选条件是用于从第一参考波形数据中筛选第五参考点的约束条件,具体可以是第一参考波形数据的结束点,也可以是第一参考波形数据中时间晚于/大于第一参考点的第一个拐点。拐点又称反曲点,是指改变曲线向上或向下方向的点,也即是指第一参考波形数据对应的曲线上凹弧与凸弧的分界点。若第一参考波形数据中时间晚于第一参考点的拐点有多个,则将该多个拐点中时间最早的拐点确定为第一拐点。若第一参考波形数据中不存在时间晚于第一参考点的拐点,则将第一参考波形数据的结束点确定为第五参考点。第三时间段具体可包括位于恢复阶段的运动后一段时间。第三时间段可与第二时间段相邻,如第二时间段的结束时间点为第三时间段的起始时间点。以恢复阶段在高频QRS波形曲线中对应的时间范围为9至12分钟为例,第三时间段比如为[9分钟20秒,12分钟]所表征的时间区间。
振幅波动幅度用于表征振幅的波动程度或变化程度,具体可用于表征第二参考波形数据中各点的振幅(也即是均方根电压)之间的波动程度。第二参考波形数据的振幅波动幅度,具体可基于该第二参考波形数据中的均方根电压的最大值与最小值确定,如将均方根电压的最大值与最小值作差得到相应振幅波动幅度。预设波动幅度可根据需求自定义,比如1uV(微伏),预设波动幅度还可根据第二参考点或第三参考点的均方根电压动态确定,预设波动幅度与第二参考点(或第三参考点)的均方根电压成正相关关系,具体可根据第二参考点(或第三参考点)的均方根电压与预设比例值动态确定预设波动幅度,比如,将第二参考点或第三参考点的均方根电压的百分之十确定为预设波动幅度,预设比例值取值为百分之十仅作为示例,并不用于具体限定。
第二参考波形数据的持续时长,是指第二参考波形数据的结束点与起始点各自对应的时间之间的差值。类似地,第二预设阈值、第三预设阈值与预设时长阈值可根据经验值自定义,如第二预设阈值设定为30%,第三预设阈值设定为56%,预设时长阈值设定为3分钟,也可根据受测者的用户画像动态确定,在此不作具体限定。
具体地,分析运动心电数据对应的每条高频QRS波形数据的波形类别是否为第一类别、第二类别或第三类别,并从中筛选相应波形类别分别为第一类别、第二类别与第三类别的高频QRS波形数据,以从运动心电数据对应的各高频QRS波形数据中,筛选出波形类别为第一类别的高频QRS波形数据、波形类别为第二类别的高频QRS波形数据,及波形类别为第三类别的高频QRS波形数据,这样,所筛选出的高频QRS波形数据包括:第一类别的高频QRS波形数据、第二类别的高频QRS波形数据与第三类别的高频QRS波形数据,以便于根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力。
分析高频QRS波形数据的波形类别是否为第一类别的步骤,包括:选取第一参考波形数据的结束点作为第五参考点,或,从第一参考波形数据中选取第一参考点之后的第一个拐点作为第五参考点;将第五参考点的均方根电压与第一参考点的均方根电压作差得到第一振幅上升绝对值,将第一振幅上升绝对值与第一参考点的均方根电压的比值确定为第一振幅上升相对值;若第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值,则判定相应高频QRS波形数据的波形类别为第一类别。
分析高频QRS波形数据的波形类别是否为第二类别的步骤,包括:遍历高频QRS波形数据中在第二时间段内各点的均方根电压,基于遍历的均方根电压,从在第二时间段内的高频QRS波形数据中选取振幅波动幅度小于或等于预设波动幅度的数据,作为第二参考波形数据;从高频QRS波形数据中选取处于第三时间段内的数据,遍历所选取的数据中各点的均方根电压,基于所遍历的均方根电压从所选取的数据中选取均方根电压最大的点作为第六参考点;将第六参考点的均方根电压与第二参考波形数据的结束点的均方根电压作差得到第二振幅上升绝对值,将第二振幅上升绝对值与第二参考波形数据的结束点的均方根电压的比值确定为第二振幅上升相对值;若第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值,则判定相应高频QRS波形数据的波形类别为第二类别。第二参考波形数据的持续时长,基于第二参考波形数据的起始点与结束点各自的时间确定。
分析高频QRS波形数据的波形类别是否为第三类别的步骤,包括:遍历高频QRS波形数据中在第二时间段内各点的均方根电压,基于遍历的均方根电压,从在第二时间段内的高频QRS波形数据中选取振幅波动幅度小于或等于预设波动幅度的数据,作为第二参考波形数据;从高频QRS波形数据中选取处于第三时间段内的数据,遍历所选取的数据中各点的均方根电压,基于所遍历的均方根电压从所选取的数据中选取均方根电压最大的点作为第六参考点;将第六参考点的均方根电压与第二参考波形数据的结束点的均方根电压作差得到第二振幅上升绝对值,将第二振幅上升绝对值与第二参考波形数据的结束点的均方根电压的比值确定为第二振幅上升相对值;若第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值大于或等于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值,则判定相应高频QRS波形数据的波形类别为第三类别。
举例说明,假设有12条心电图导联,该12条心电图导联各自对应的高频QRS波形数据中,波形类别为第一类别的高频QRS波形数据有2条,波形类别为第二类别的高频QRS波形数据有1条,波形类别为第三类别的高频QRS波形数据有1条,则从12条高频QRS波形数据中筛选相应波形类别为第一类别、第二类别与第三类别的高频QRS波形数据,并基于所筛选出的4条高频QRS波形数据确定血管响应能力。
在一些实施例中,以在第二时间段内的高频QRS波形数据为目标波形数据,具体可参照现有技术从目标波形数据中选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据,在此不再赘述。例如,首先从目标波形数据上选取相应振幅波动幅度满足要求(振幅波动幅度小于或等于预设波动幅度)、且持续时长较短(如1分钟或30秒)的数据作为候选数据,然后以该候选数据为基准,基于目标波形数据中与该候选数据前相邻和/或后相邻的点扩充该候选数据的范围,若扩充范围后的候选数据对应的振幅波动幅度仍然满足要求,则按照上述方式继续扩充候选数据,直至扩充后的候选数据对应的振幅波动幅度不满足要求,则停止候选数据的范围扩充,将前一次范围扩充得到的候选数据确定为第二参考波形数据。基于第二参考波形数据确定的曲线是相应高频QRS波形曲线中的连续子段。
在一些实施例中,通过并行或串行的方式分析每条高频QRS波形数据的波形类别是否为第一类别、第二类别或第三类别。对于串行分析方式,可按照预设顺序根据每种预设类别对应的波形分析函数依次进行分析,若基于当前的波形分析函数判定高频QRS波形数据的波形类别不是相应预设类别,则按照预设顺序基于下一种预设类别对应的波形分析函数继续分析,直至满足停止条件,停止当前分析流程,停止条件包括按照预设顺序遍历完毕所有的预设类别,或者,基于当前的波形分析函数判定高频QRS波形数据的波形类别为相应预设类别。预设顺序在此不做具体限定。在本实施例中预设类别包括第一类别、第二类别与第三类别,若预设类别包括更多或更少类别,可参考类似逻辑进行处理。若高频QRS波形数据的波形类别为任一种预设类别(即高频QRS波形数据的波形类别为第一类别、第二类别与第三类别中的任一种),则判定该高频QRS波形数据的波形类别为预设类别。预设类别对应的波形分析函数,可包括本申请的一个或多个实施例中提供的分析高频QRS波形数据是否为相应预设类别的相关步骤,在此不再赘述。
上述实施例中,波形类别为第一类别、第二类别或第三类别的高频QRS波形数据,更能反映冠脉血管响应能力,由此,筛选相应波形类别为第一类别、第二类别与第三类别的高频QRS波形数据,以便于基于所筛选出的高频QRS波形数据得到准确性更高的血管响应能力。
在一些实施例中,筛选波形类别为第一类别与第二类别的高频QRS波形数据,或者,筛选波形类别为第一类别与第三类别的高频QRS波形数据,或者,筛选波形类别为第二类别与第三类别的高频QRS波形数据,并根据所筛选出的高频QRS波形数据确定血管响应能力。在本实施例中,预设类别包括第一类别与第二类别,或,第一类别与第三类别,或,第二类别与第三类别,以便于基于波形类别为预设类别的高频QRS波形数据确定血管响应能力。
在一些实施例中,S116包括:筛选相应波形类别为第一类别的高频QRS波形数据;或,筛选相应波形类别为第二类别的高频QRS波形数据;或,筛选相应波形类别为第三类别的高频QRS波形数据;第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;第二类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;第三类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值大于或等于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;第一振幅上升相对值的确定步骤,包括:从第一参考波形数据中选取满足筛选条件的第五参考点;第五参考点的时间晚于第一参考点;基于第一参考点与第五参考点各自的均方根电压确定第一振幅上升相对值;第二振幅上升相对值的确定步骤,包括:从在第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;基于第二参考波形数据的结束点与第六参考点各自的均方根电压确定第二振幅上升相对值。
具体地,分析运动心电数据对应的每条高频QRS波形数据的波形类别是否为第一类别,从中筛选相应波形类别为第一类别的高频QRS波形数据,以便于根据波形类别为第一类别的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力。或者,分析运动心电数据对应的每条高频QRS波形数据的波形类别是否为第二类别,从中筛选相应波形类别为第二类别的高频QRS波形数据,以便于根据波形类别为第二类别的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力。或者,分析运动心电数据对应的每条高频QRS波形数据的波形类别是否为第三类别,从中筛选相应波形类别为第三类别的高频QRS波形数据,以便于根据波形类别为第三类别的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力。
在一些实施例中,若第一振幅下降相对值大于或等于第一预设阈值,且第一振幅上升相对值大于或等于第二预设阈值,表征相应高频QRS波形数据中包括V型波段,则判定相应高频QRS波形数据对应的波形类别为V型(第一类别),并按照本申请的一个或多个实施例中提供的方式,根据相应波形类别为V型的各高频QRS波形数据进一步确定血管响应能力。可以理解,图2所示的高频QRS波形数据的波形类别为V型。这样,通过V型对应的波形分析函数量化高频QRS波形数据的波形变化情况,以分析高频QRS波形数据的波形类别是否为V型,以便于在此基础上,基于波形类别为V型的各高频QRS波形曲线准确确定血管响应能力。
在一些实施例中,若第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值,表征相应高频QRS波形数据中包括L型波段,则判定相应高频QRS波形数据的波形类别为L型,以便于基于波形类别为L型的各高频QRS波形数据进一步确定血管响应能力。这样,通过L型对应的波形分析函数量化高频QRS波形数据的波形变化情况,以分析高频QRS波形数据的波形类别是否为L型,以便于在此基础上,基于波形类别为L型的各高频QRS波形数据准确确定血管响应能力。
在一些实施例中,图3提供了基于高频QRS波形数据选取各参考点与参考波形数据的示意图。如图3所示,高频QRS波形图中显示有心电图导联aVL对应的高频QRS波形数据,运动阶段在该高频QRS波形数据中对应的时间范围为0至9分钟,第一时间段包括运动中(运动阶段)的前3分钟,处于第一时间段内的高频QRS波形数据为第一参考波形数据,第一参考波形数据中均方根电压最小的点为第一参考点,第一参考波形数据中时间早于第一参考点、且均方根电压最大的点作为第二参考点,第二时间段包括运动前的100秒(位于静息阶段)、运动阶段的9分钟与运动后的20秒(位于恢复阶段),在第二时间段内、且振幅波形幅度小于或等于预设波动幅度(如0.5uV)的数据为第二参考波形数据,在第二时间段内均方根电压最大的点为第三参考点,时间晚于第三参考点、且均方根电压最小的点为第四参考点,第三时间段包括从运动结束后的第20秒至负荷运动检测过程结束的时间区间,具体如[9分钟20秒,12分钟]所表征的时间区间,处于第三时间段内的高频QRS波形数据中均方根电压最大的点为第六参考点,基于第三参考点与第四参考点各自的均方根电压,所确定的第二振幅下降绝对值与第二振幅下降相对值分别为3.3uV与56%,图3所示高频QRS波形数据对应的最大电压与电压差分别为10uV与3.3uV,且其波形类别为L型。可以理解,在图示的高频QRS波形曲线中,第一参考点与第四参考点为同一个点。图3所示的高频QRS波形数据及对应选取的各参考点与参考波形数据,以及第一参考点与第二参考点的选取仅作为示例,并不用于具体限定。
在一些实施例中,若第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值大于或等于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值,表征相应高频QRS波形数据中包括U型波段,则判定相应高频QRS波形数据的波形类别为U型,并基于波形类别为U型的各高频QRS波形曲线进一步确定血管响应能力。这样,通过U型对应的波形分析函数量化高频QRS波形数据的波形变化情况,以分析高频QRS波形数据的波形类别是否为U型,以便于在此基础上,基于波形类别为U型的各高频QRS波形数据准确确定血管响应能力。
在一些实施例中,图4提供了基于高频QRS波形数据选取各参考点与参考波形数据的示意图。如图4所示,高频QRS波形图中显示有心电图导联V5对应的高频QRS波形数据,运动阶段在该高频QRS波形数据中对应的时间范围为0至9分钟,第一时间段包括运动前的100秒(位于静息阶段)与运动中(运动阶段)的前3分钟,处于第一时间段内的高频QRS波形数据为第一参考波形数据,第一参考波形数据中均方根电压最小的点为第一参考点,第一参考波形数据中时间早于第一参考点、且均方根电压最大的点作为第二参考点,第二时间段包括运动前的100秒(位于静息阶段)、运动阶段的9分钟与运动后的20秒(位于恢复阶段),在第二时间段内、且振幅波形幅度小于或等于预设波动幅度(如0.5uV)的数据为第二参考波形数据,第二时间段内均方根电压最大的点为第三参考点,时间晚于第三参考点、且均方根电压最小的点为第四参考点,第三时间段包括从运动结束后的第20秒至负荷运动检测过程结束的时间区间,具体如[9分钟20秒,12分钟]所表征的时间区间,处于第三时间段内的高频QRS波形数据中均方根电压最大的点为第六参考点,基于第三参考点与第四参考点各自的均方根电压,所确定的第二振幅下降绝对值与第二振幅下降相对值分别为3.2uV与63%,图4所示高频QRS波形数据对应的最大电压与电压差分别为10uV与3.2uV,且其波形类别为U型。在本实施例中,第二参考点与第三参考点为同一个点。图4所示的高频QRS波形数据及对应选取的各参考点与参考波形数据,以及第一参考点与第二参考点的选取仅作为示例,并不用于具体限定。
在本申请的一个或多个实施例中,若第一时间段包括运动前一段时间与运动中的一段时间,则第一类别、第二类别与第三类别各自的波形特征还包括:第一参考点与第二参考点之间的时间间隔小于或等于预设时间间隔。以第一类别为例,第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值、且第一参考点与第二参考点之间的时间间隔小于或等于预设时间间隔,在此不一一列举。
在一些实施例中,S118包括:根据所筛选出的高频QRS波形数据确定参考指标;参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项;根据参考指标确定血管响应能力。
参考指标中的电压差与最大电压的比值,是指所筛选出的各高频QRS波形数据对应的电压差与最大电压的比值中的最大值,可理解为电压差与最大电压的目标比值,目标振幅下降相对值是指所筛选出的各高频QRS波形数据对应的第二振幅下降相对值中的最大值,目标波形下降区域面积是指所筛选出的各高频QRS波形数据对应的波形下降区域面积的和值、平均值或最大值。
具体地,根据所筛选出的各高频QRS波形数据确定电压差与最大电压的比值,还确定目标振幅下降相对值、目标波形下降区域面积等参考指标中的至少一项,并在电压差与最大电压的比值基础上,结合目标振幅下降相对值、目标波形下降区域面积等中的至少一项确定血管响应能力。
在本申请的一个或多个实施例中,若考虑高频QRS波形数据对应的波形类别,筛选波形类别为预设类别的高频QRS波形数据确定参考指标,则参考指标中的电压差与最大电压的比值,是指相应波形类别为预设类别的各高频QRS波形数据对应的电压差与最大电压的比值中的最大值,目标振幅下降相对值是指相应波形类别为预设类别的各高频QRS波形数据所对应的第二振幅下降相对值中的最大值,目标波形下降区域面积是指相应波形类别为预设类别的各高频QRS波形数据所对应的波形下降区域面积的和值、平均值或最大值。预设类别包括第一类别(如V型)、第二类别(如L型)与第三类别(如U型)中的至少一种。
以预设类别包括L型为例,参考指标中的电压差与最大电压的比值,指相应波形类别为L型的各高频QRS波形数据对应的电压差与最大电压的比值中的最大值。以预设类别包括V型、U型与L型为例,分析每条高频QRS波形数据的波形类别是否为V型、U型或L型,筛选波形类别为V型的高频QRS波形数据、U型的高频QRS波形数据与L型的高频QRS波形数据,若波形类别为V型的高频QRS波形数据有2条,波形类别为L型的高频QRS波形数据有1条,波形类别为U型的高频QRS波形数据有1条,则根据所筛选出的4条高频QRS波形数据确定参考指标,具体可参照本申请的一个或多个实施例中提供的方式,根据所筛选出的4条高频QRS波形数据确定各参考指标,在此不再赘述。
在一些实施例中,根据所筛选出的高频QRS波形数据确定目标振幅下降相对值,包括:对于所筛选出的每条高频QRS波形数据,根据相应第三参考点与第四参考点各自的均方根电压确定第二振幅下降相对值;将所筛选出的各高频QRS波形数据对应的第二振幅下降相对值中的最大值确定为目标振幅下降相对值。具体地,将第三参考点的均方根电压与相应第四参考点的均方根电压作差得到第二振幅下降相对值,将第二振幅下降相对值与第三参考点的均方根电压的比值作为第二振幅下降相对值。可以理解,若高频QRS波形数据的波形类别为V型,则将第一参考点选作为第四参考点,将对应确定的第一振幅下降相对值确定为第二振幅下降相对值。若高频QRS波形数据的波形类别为U型或L型,从第二参考波形数据上选取均方根电压最小的点作为第四参考点。
在一些实施例中,目标振幅下降相对值能够反映冠脉血管响应能力,二者成负相关相关。基于目标振幅下降相对值能够确定血管响应能力,如目标振幅下降相对值越大,则标注相应血管响应能力越小或越低,以表征冠脉血管响应能力越弱。由此,根据电压差与最大电压的比值、目标振幅下降相对值,能够得到更为准确的血管响应能力,具体可根据二者各自所处的阈值区间确定血管响应能力。具体地,将电压差与最大电压的比值、目标振幅下降相对值分别与各自的阈值区间进行比较,以将所处阈值区间的参考优先级确定为相应参考指标的参考优先级,并筛选参考优先级较高的参考指标或维度用于确定血管响应能力。或者,根据电压差与最大电压的比值、目标振幅下降相对值各自所处的阈值区间分别确定血管响应能力,并从中筛选关注优先级较高的血管响应能力作为最终的血管响应能力。可以理解,若电压差与最大电压的比值、目标振幅下降相对值各自对应的参考优先级相同,则任选其一用于确定血管响应能力。
举例说明,针对目标振幅下降相对值,预配置有参考优先级依次降低的第一幅度阈值区间至第四幅度阈值区间共四个幅度阈值区间,比如分别为:大于或等于66%、大于或等于60%且小于66%、大于或等于50%且小于60%、大于或等于40%且小于50%,各自对应的参考优先级分别记为第一级至第四级。比如,若目标振幅下降相对值处于第一幅度阈值区间,将目标振幅下降相对值的参考优先级确定为参考优先级最高的第一级,类似地,若电压差与最大电压的比值处于第二比值阈值区间,将电压差与最大电压的比值的参考优先级确定为次高的第二级,由于目标振幅下降相对值的参考优先级(第一级)高于电压差与最大电压的比值的参考优先级(第二级),则根据目标振幅下降相对值所处的幅度阈值区间确定血管响应能力,又由于目标振幅下降相对值处于第一幅度阈值区间,则将血管响应能力确定为关注优先级最高的第一级。
还比如,若目标振幅下降相对值处于第一幅度阈值区间,将血管响应能力确定为关注优先级最高的第一级,若电压差与最大电压的比值处于第二比值阈值区间,将血管响应能力确定为关注优先级次高的第二级,通过比较筛选关注优先级较高的第二级作为最终的血管响应能力。参照电压差与最大电压的比值、血管响应能力的对应关系可知,若目标振幅下降相对值处于第二幅度阈值区间,将血管响应能力确定为关注优先级次高的第二级,依此类推,在此不一一列举。
在一些实施例中,根据所筛选出的高频QRS波形数据确定目标波形下降区域面积,包括:从所筛选出的高频QRS波形数据中选取第七参考点与第八参考点;根据第七参考点、第八参考点与高频QRS波形数据确定波形下降区域面积;将所筛选出的各高频QRS波形数据对应的波形下降区域面积的和值、平均值或最大值确定为目标波形下降区域面积。
具体地,对于所筛选出的每条高频QRS波形数据,将运动阶段的起始点在该高频QRS波形数据中对应的点作为第七参考点,或,将第二参考点(或第三参考点)作为第七参考点,并将运动阶段的结束点在该高频QRS波形数据中对应的点作为第八参考点。将第七参考点的均方根电压确定为参考振幅,将由参考振幅、第八参考点与高频QRS波形数据确定的、且处于参考振幅下方的封闭区域确定为波形下降区域,通过第一函数计算该封闭区域的面积得到绝对下降面积,将该绝对下降面积作为相应高频QRS波形数据的波形下降区域面积。或,将由第七参考点、第八参考点、高频QRS波形数据与均方根电压为零的基准轴(高频QRS波形图的横轴)确定的封闭区域作为参考区域,通过第二函数计算该参考区域的面积得到参考面积,将绝对下降面积与参考面积的比值确定为相对下降面积,将该相对下降面积作为相应高频QRS波形数据的波形下降区域面积。或,将按照上述方式计算得到的绝对下降面积与相对下降面积,作为相应高频QRS波形数据的波形下降区域面积。第七参考点的时间早于第八参考点的时间。
在一些实施例中,目标波形下降区域面积可用于反映冠脉血管响应能力,二者成负相关关系。基于目标波形下降区域面积能够确定相应血管响应能力,如目标波形下降区域面积越大,则标注相应血管响应能力越低或越小(关注优先级越高),以表征冠脉血管响应能力越弱。由此,根据电压差与最大电压的比值、目标波形下降区域面积,能够得到更为准确的血管响应能力,具体可根据二者各自所处的阈值区间确定血管响应能力。
举例说明,以结合目标波形下降区域面积、电压差与最大电压的比值确定血管响应能力为例,预配置有参考优先级依次降低的第一面积阈值区间至第三面积阈值区间共三个面积阈值区间,若电压差与最大电压的比值处于第一比值阈值区间,且目标波形下降区域面积处于第一面积阈值区间,则标注血管响应能力为第一级,若电压差与最大电压的比值处于第二比值阈值区间,且目标波形下降区域面积处于第一面积阈值区间,则标注血管响应能力为第二级,在此不一一列举。可以理解,面积阈值区间的参考优先级越高,该面积阈值区间中的数值越大。若波形下降区域面积包括绝对下降面积和/或相对下降面积,则针对波形下降区域面积预配置的面积阈值区间,包括针对绝对下降面积预配置的绝对面积阈值区间,和/或,针对相对下降面积预配置的相对面积阈值区间。由此,若目标波形下降区域面积处于第一面积阈值区间,则其所包括的目标绝对下降面积和/或目标相对下降面积分别处于该第一面积阈值区间中的相应面积阈值区间,在此不再赘述。
在一些实施例中,根据电压差与最大电压的比值、目标波形下降区域面积、目标振幅下降相对值,能够得到更为准确的血管响应能力。具体而言,基于各参考指标各自所处的阈值区间能够得到相应的多种组合方式,参照本申请的一个或多个实施例中提供的血管响应能力确定方式,根据各参考指标的各种组合方式能够得到相应血管响应能力,在此不再赘述。例如,若目标波形下降区域面积处于第一面积阈值区间、且目标振幅下降相对值处于第一幅度阈值区间和/或电压差与最大电压的比值处于第一比值阈值区间,则标注血管响应能力为关注优先级最高的第一级。
上述实施例中,在电压差与最大电压的比值的基础上,还结合目标振幅下降相对值、目标波形下降区域面积中的至少一项,能够得到更为准确的血管响应能力供医生参考。
在一些实施例中,上述高频QRS波形数据分析方法还包括:根据运动心电数据对应的高频QRS波形数据确定阳性数量;S118包括:根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值,以及阳性数量确定血管响应能力;或,根据所筛选出的高频QRS波形数据确定参考指标,并根据参考指标与阳性数量确定血管响应能力;参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项。
具体地,根据运动心电数据对应的每条高频QRS波形数据分别确定相应导联阳性指标,从运动心电数据对应的各高频QRS波形数据中筛选并统计导联阳性指标指示为阳性的高频QRS波形数据,得到运动心电数据对应的阳性数量,根据所筛选出的高频QRS波形数据确定电压差与最大电压的比值,并根据所确定的电压差与最大电压的比值、阳性数量确定血管响应能力。或者,按照本申请的一个或多个实施例中提供的方式,根据所筛选出的高频QRS波形数据确定参考指标,并根据参考指标与阳性数量确定血管响应能力。
在一些实施例中,对于运动心电数据对应的每条高频QRS波形数据,根据第三参考点与第四参考点各自的均方根电压确定第二振幅下降绝对值与第二振幅下降相对值,并根据第二振幅下降相对值与第二振幅下降相对值确定相应高频QRS波形数据的导联阳性指标。若高频QRS波形数据的第二振幅下降绝对值与第二振幅下降相对值均符合预设的导联阳性条件,则导联阳性指标指示相应心电图导联为阳性。预设的导联阳性条件可根据实际检测情况自定义,可根据受测者的年龄、性别、身高、体重等因素进行适应性调整,比如,第二振幅下降绝对值大于1uV且第二振幅下降相对值大于50%,在此不作具体限定。
在一些实施例中,阳性数量可用于反应冠脉血管响应能力,二者成负相关关系。基于阳性数量能够确定相应血管响应能力,如阳性数量越大,则标注相应血管响应能力越低或越小(关注优先级越高),以表征冠脉血管响应能力越弱。由此,根据电压差与最大电压的比值、阳性数量,能够得到更为准确的血管响应能力,具体可根据二者各自所处的阈值区间确定血管响应能力。
举例说明,以结合阳性数量、电压差与最大电压的比值确定血管响应能力为例,针对阳性数量预配置有参考优先级依次降低的第一数量阈值区间至第四数量阈值区间共四个数量阈值区间,比如分别为:大于或等于7、大于或等于5且小于7、大于或等于3且小于5、大于或等于1且小于3,若电压差与最大电压的比值处于第一比值阈值区间,且阳性数量处于第一数量阈值区间,则标注血管响应能力为第一级,若电压差与最大电压的比值处于第二比值阈值区间,且阳性数量处于第一数量阈值区间,则标注血管响应能力为第二级,在此不一一列举。可以理解,若电压差与最大电压的比值所处的比值阈值区间的参考优先级较高,而阳性数量所处的数量阈值区间的参考优先级较低,可以适当下调血管响应能力的关注优先级。
在一些实施例中,基于本申请的一个或多个实施例中提供的基于参考指标确定血管响应能力的方式可知,在电压差与最大电压的比值、阳性数量的基础上,还结合目标振幅下降相对值与目标波形下降区域面积中的至少一项,能够得到更为准确的血管响应能力,具体结合方式及其对应的血管响应能力确定方式,可参照相应实施例的记载,在此不再赘述。例如,若阳性数量处于第一数量阈值区间、且目标波形下降区域面积处于第一面积阈值区间、且目标振幅下降相对值处于第一幅度阈值区间和/或电压差与最大电压的比值处于第一比值阈值区间,则标注血管响应能力为关注优先级最高的第一级。
如图5所示,在一些实施例中,提供了一种高频QRS波形数据分析方法,该方法具体包括以下步骤:
S502,获取运动心电数据对应的高频QRS波形数据。
S504,选取在第一时间段内的高频QRS波形数据作为第一参考波形数据。
S506,根据第一参考波形数据中均方根电压最小的点确定第一参考点,以及时间早于第一参考点、且均方根电压最大的点确定第二参考点。
S508,根据第一参考点与第二参考点各自的均方根电压确定第一振幅下降相对值。
S510,根据高频QRS波形数据确定最大电压。
S512,从在第二时间段内的高频QRS波形数据中选取均方根电压最大的点作为第三参考点,以及时间晚于第三参考点、且均方根电压最小的点作为第四参考点。
S514,根据第三参考点与第四参考点各自的均方根电压确定电压差。
S516,从第一参考波形数据中选取满足筛选条件的第五参考点;第五参考点的时间晚于第一参考点。
S518,基于第一参考点与第五参考点各自的均方根电压确定第一振幅上升相对值。
S520,筛选第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值的高频QRS波形数据。
S522,从在第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据。
S524,从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点。
S526,基于第二参考波形数据的结束点与第六参考点各自的均方根电压确定第二振幅上升相对值。
S528,筛选第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值的高频QRS波形数据。
S530,筛选第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值大于或等于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值的高频QRS波形数据。
S532,根据所筛选出的高频QRS波形数据确定参考指标,并根据参考指标确定血管响应能力;参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项。
S534,根据运动心电数据对应的高频QRS波形数据确定阳性数量。
S536,根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值,以及阳性数量确定血管响应能力。
S538,根据所筛选出的高频QRS波形数据确定参考指标,并根据参考指标与阳性数量确定血管响应能力;参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项。
上述实施例中,分析每条高频QRS波形数据的波形类别是否为预设类别(如第一类别、第二类别或第三类别),筛选波形类别为第一类别、第二类别与第三类别的高频QRS波形数据,用于确定包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项的参考指标,以根据参考指标确定血管响应能力,或者,根据运动心电数据对应的高频QRS波形数据确定阳性数量,并根据阳性数量、电压差与最大电压的比值(或,参考指标)确定血管响应能力,以通过无创方式准确评估得到血管响应能力供医生参考,以便于医生结合临床症状等准确识别受测者的心脏健康状况。
应该理解的是,虽然图1和图5的流程图中的各个步骤按照箭头的指示依次显示,但是这些步骤并不是必然按照箭头指示的顺序依次执行。除非本文中有明确的说明,这些步骤的执行并没有严格的顺序限制,这些步骤可以以其它的顺序执行。而且,图1和图5中的至少一部分步骤可以包括多个步骤或者多个阶段,这些步骤或者阶段并不必然是在同一时刻执行完成,而是可以在不同的时刻执行,这些步骤或者阶段的执行顺序也不必然是依次进行,而是可以与其它步骤或者其它步骤中的步骤或者阶段的至少一部分轮流或者交替地执行。
在一些实施例中,如图6所示,提供了一种高频QRS波形数据分析装置600,包括:获取模块601、选取模块602、指标确定模块603、筛选模块604,其中:
获取模块601,用于获取运动心电数据对应的高频QRS波形数据;
选取模块602,用于选取在第一时间段内的高频QRS波形数据作为第一参考波形数据;
选取模块602,还用于根据第一参考波形数据中选取均方根电压最小的点确定第一参考点,以及时间早于第一参考点、且均方根电压最大的点确定第二参考点;
指标确定模块603,用于根据第一参考点与第二参考点各自的均方根电压确定第一振幅下降相对值;
指标确定模块603,还用于根据高频QRS波形数据确定最大电压;
选取模块602,用于从在第二时间段内的高频QRS波形数据中选取均方根电压最大的点作为第三参考点,以及时间晚于第三参考点、且均方根电压最小的点作为第四参考点;
指标确定模块603,还用于根据第三参考点与第四参考点各自的均方根电压确定电压差;
筛选模块604,用于筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据;
指标确定模块603,用于根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力。
在一些实施例中,筛选模块604,还用于筛选相应波形类别为第一类别、第二类别与第三类别的高频QRS波形数据;第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;第二类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;第三类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值大于或等于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;选取模块602,还用于从第一参考波形数据中选取满足筛选条件的第五参考点;第五参考点的时间晚于第一参考点;指标确定模块603,还用于基于第一参考点与第五参考点各自的均方根电压确定第一振幅上升相对值;选取模块602,还用于从在第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;指标确定模块603,还用于基于第二参考波形数据的结束点与第六参考点各自的均方根电压确定第二振幅上升相对值。
在一些实施例中,筛选模块604,还用于筛选相应波形类别为第一类别的高频QRS波形数据;或,筛选相应波形类别为第二类别的高频QRS波形数据;或,筛选相应波形类别为第三类别的高频QRS波形数据;第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;第二类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;第三类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、第二振幅上升相对值大于或等于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;选取模块602,还用于从第一参考波形数据中选取满足筛选条件的第五参考点;第五参考点的时间晚于第一参考点;指标确定模块603,还用于基于第一参考点与第五参考点各自的均方根电压确定第一振幅上升相对值;选取模块602,还用于从在第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;指标确定模块603,还用于基于第二参考波形数据的结束点与第六参考点各自的均方根电压确定第二振幅上升相对值。
在一些实施例中,指标确定模块603,还用于根据所筛选出的高频QRS波形数据确定参考指标;参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项;根据参考指标确定血管响应能力。
在一些实施例中,指标确定模块603,还用于根据运动心电数据对应的高频QRS波形数据确定阳性数量;根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值,以及阳性数量确定血管响应能力;或,根据所筛选出的高频QRS波形数据确定参考指标,并根据参考指标与阳性数量确定血管响应能力;参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项。
关于高频QRS波形数据分析装置的具体限定可以参见上文中对于高频QRS波形数据分析方法的限定,在此不再赘述。上述高频QRS波形数据分析装置中的各个模块可全部或部分通过软件、硬件及其组合来实现。上述各模块可以硬件形式内嵌于或独立于计算机设备中的处理器中,也可以以软件形式存储于计算机设备中的存储器中,以便于处理器调用执行以上各个模块对应的操作。
在一些实施例中,提供了一种计算机设备,该计算机设备可以是服务器,其内部结构图可以如图7所示。该计算机设备包括通过系统总线连接的处理器、存储器和网络接口。该计算机设备的处理器用于提供计算和控制能力。该计算机设备的存储器包括非易失性存储介质、内存储器。该非易失性存储介质存储有操作系统、计算机可读指令和数据库。该内存储器为非易失性存储介质中的操作系统和计算机可读指令的运行提供环境。该计算机设备的数据库用于存储运动心电数据对应的高频QRS波形数据。该计算机设备的网络接口用于与外部的终端通过网络连接通信。该计算机可读指令被处理器执行时以实现一种高频QRS波形数据分析方法。
本领域技术人员可以理解,图7中示出的结构,仅仅是与本申请方案相关的部分结构的框图,并不构成对本申请方案所应用于其上的计算机设备的限定,具体的计算机设备可以包括比图中所示更多或更少的部件,或者组合某些部件,或者具有不同的部件布置。
在一些实施例中,还提供了一种计算机设备,包括存储器和处理器,存储器存储有计算机可读指令,该处理器执行计算机可读指令时实现各方法实施例中的步骤
在一些实施例中,提供了一种计算机可读存储介质,其上存储有计算机可读指令,该计算机可读指令被处理器执行时实现各方法实施例中的步骤。
本领域普通技术人员可以理解实现上述实施例方法中的全部或部分流程,是可以通过计算机可读指令来指令相关的硬件来完成,所述的计算机可读指令可存储于一非易失性计算机可读取存储介质中,该计算机可读指令在执行时,可包括如上述各方法的实施例的流程。本申请所提供的各实施例中所使用的对存储器、存储、数据库或其它介质的任何引用,均可包括非易失性和易失性存储器中的至少一种。非易失性存储器可包括只读存储器(Read-Only Memory,ROM)、磁带、软盘、闪存或光存储器等。易失性存储器可包括随机存取存储器(Random Access Memory,RAM)或外部高速缓冲存储器。作为说明而非局限,RAM可以是多种形式,比如静态随机存取存储器(Static Random Access Memory,SRAM)或动态随机存取存储器(Dynamic Random Access Memory,DRAM)等。
以上实施例的各技术特征可以进行任意的组合,为使描述简洁,未对上述实施例中的各个技术特征所有可能的组合都进行描述,然而,只要这些技术特征的组合不存在矛盾,都应当认为是本说明书记载的范围。
以上所述实施例仅表达了本申请的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本申请构思的前提下,还可以做出若干变形和改进,这些都属于本申请的保护范围。因此,本申请专利的保护范围应以所附权利要求为准。
Claims (12)
- 一种高频QRS波形数据分析方法,包括:获取运动心电数据对应的高频QRS波形数据;选取在第一时间段内的高频QRS波形数据作为第一参考波形数据;所述第一时间段由运动前一段时间与运动中的一段时间组成,或者,由运动中的一段时间组成;根据所述第一参考波形数据中均方根电压最小的点确定第一参考点,以及时间早于所述第一参考点、且均方根电压最大的点确定第二参考点;根据所述第一参考点与所述第二参考点各自的均方根电压确定第一振幅下降相对值;根据所述高频QRS波形数据确定最大电压;从在第二时间段内的高频QRS波形数据中选取均方根电压最大的点作为第三参考点,以及时间晚于所述第三参考点、且均方根电压最小的点作为第四参考点;根据所述第三参考点与所述第四参考点各自的均方根电压确定电压差;筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据;根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力;所述根据所述高频QRS波形数据确定最大电压,包括:从所述高频QRS波形数据中获取均方根电压的最大值作为目标电压,根据所述目标电压确定最大电压。
- 根据权利要求1所述的方法,其特征在于,所述筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据,包括:筛选相应波形类别为第一类别、第二类别与第三类别的高频QRS波形数据;所述第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;所述第二类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;所述第三类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值大于或等于所述第三预设阈值、且第二参考波形数据的持续时长大于或等于所述预设时长阈值;所述第一振幅上升相对值的确定步骤,包括:从所述第一参考波形数据中选取满足筛选条件的第五参考点;所述第五参考点的时间晚于所述第一参考点;基于所述第一参考点与所述第五参考点各自的均方根电压确定第一振幅上升相对值;所述第二振幅上升相对值的确定步骤,包括:从在所述第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;基于所述第二参考波形数据的结束点与所述第六参考点各自的均方根电压确定第二振幅上升相对值。
- 根据权利要求1所述的方法,其特征在于,所述筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据,包括:筛选相应波形类别为第一类别的高频QRS波形数据;或,筛选相应波形类别为第二类别的高频QRS波形数据;或,筛选相应波形类别为第三类别的高频QRS波形数据;所述第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;所述第二类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;所述第三类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值大于或等于所述第三预设阈值、且第二参考波形数据的持续时长大于或等于所述预设时长阈值;所述第一振幅上升相对值的确定步骤,包括:从所述第一参考波形数据中选取满足筛选条件的第五参考点;所述第五参考点的时间晚于所述第一参考点;基于所述第一参考点与所述第五参考点各自的均方根电压确定第一振幅上升相对值;所述第二振幅上升相对值的确定步骤,包括:从在所述第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;基于所述第二参考波形数据的结束点与所述第六参考点各自的均方根电压确定第二振幅上升相对值。
- 根据权利要求1至3任意一项所述的方法,其特征在于,所述根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力,包括:根据所筛选出的高频QRS波形数据确定参考指标;所述参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项;根据所述参考指标确定血管响应能力。
- 根据权利要求1至3任意一项所述的方法,其特征在于,还包括:根据所述运动心电数据对应的高频QRS波形数据确定阳性数量;所述根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力,包括:根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值,以及所述阳性数量确定血管响应能力;或,根据所筛选出的高频QRS波形数据确定参考指标,并根据所述参考指标与所述阳性数量确定血管响应能力;所述参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项。
- 一种高频QRS波形数据分析装置,包括:获取模块,用于获取运动心电数据对应的高频QRS波形数据;选取模块,用于选取在第一时间段内的高频QRS波形数据作为第一参考波形数据;所述第一时间段由运动前一段时间与运动中的一段时间组成,或者,由运动中的一段时间组成;所述选取模块,还用于根据所述第一参考波形数据中均方根电压最小的点确定第一参考点,以及时间早于所述第一参考点、且均方根电压最大的点确定第二参考点;指标确定模块,用于根据所述第一参考点与所述第二参考点各自的均方根电压确定第一振幅下降相对值;所述指标确定模块,还用于根据所述高频QRS波形数据确定最大电压;所述选取模块,用于从在第二时间段内的高频QRS波形数据中选取均方根电压最大的点作为第三参考点,以及时间晚于所述第三参考点、且均方根电压最小的点作为第四参考点;所述指标确定模块,还用于根据所述第三参考点与所述第四参考点各自的均方根电压确定电压差;筛选模块,用于筛选第一振幅下降相对值大于或等于第一预设阈值的高频QRS波形数据;指标确定模块,用于根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值确定血管响应能力;所述指标确定模块,还用于从所述高频QRS波形数据中获取均方根电压的最大值作为目标电压,根据所述目标电压确定最大电压。
- 根据权利要求6所述的装置,其特征在于,所述筛选模块,还用于筛选相应波形类别为第一类别、第二类别与第三类别的高频QRS波形数据;所述第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;所述第二类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;所述第三类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值大于或等于所述第三预设阈值、且第二参考波形数据的持续时长大于或等于所述预设时长阈值;所述选取模块,还用于从所述第一参考波形数据中选取满足筛选条件的第五参考点;所述第五参考点的时间晚于所述第一参考点;所述指标确定模块,还用于基于所述第一参考点与所述第五参考点各自的均方根电压确定第一振幅上升相对值;所述选取模块,还用于从在所述第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;所述指标确定模块,还用于基于所述第二参考波形数据的结束点与所述第六参考点各自的均方根电压确定第二振幅上升相对值。
- 根据权利要求6所述的装置,其特征在于,所述筛选模块,还用于筛选相应波形类别为第一类别的高频QRS波形数据;或,筛选相应波形类别为第二类别的高频QRS波形数据;或,筛选相应波形类别为第三类别的高频QRS波形数据;所述第一类别的波形特征包括:第一振幅下降相对值大于或等于第一预设阈值、且第一振幅上升相对值大于或等于第二预设阈值;所述第二类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值小于第三预设阈值、且第二参考波形数据的持续时长大于或等于预设时长阈值;所述第三类别的波形特征包括:第一振幅下降相对值大于或等于所述第一预设阈值、第二振幅上升相对值大于或等于所述第三预设阈值、且第二参考波形数据的持续时长大于或等于所述预设时长阈值;所述选取模块,还用于从所述第一参考波形数据中选取满足筛选条件的第五参考点;所述第五参考点的时间晚于所述第一参考点;所述指标确定模块,还用于基于所述第一参考点与所述第五参考点各自的均方根电压确定第一振幅上升相对值;所述选取模块,还用于从在所述第二时间段内的高频QRS波形数据中,选取振幅波动幅度小于或等于预设波动幅度的第二参考波形数据;从在第三时间段内的高频QRS波形数据中选取均方根电压最大的点作为第六参考点;所述指标确定模块,还用于基于所述第二参考波形数据的结束点与所述第六参考点各自的均方根电压确定第二振幅上升相对值。
- 根据权利要求6至8任意一项所述的装置,其特征在于,所述指标确定模块,还用于根据所筛选出的高频QRS波形数据确定参考指标;所述参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项;根据所述参考指标确定血管响应能力。
- 根据权利要求6至8任意一项所述的装置,其特征在于,所述指标确定模块,还用于根据所述运动心电数据对应的高频QRS波形数据确定阳性数量;根据所筛选出的高频QRS波形数据对应的电压差与最大电压的比值,以及所述阳性数量确定血管响应能力;或,根据所筛选出的高频QRS波形数据确定参考指标,并根据所述参考指标与所述阳性数量确定血管响应能力;所述参考指标包括电压差与最大电压的比值,还包括目标振幅下降相对值、目标波形下降区域面积中的至少一项。
- 一种计算机设备,包括存储器和处理器,所述存储器存储有计算机可读指令,其特征在于,所述处理器执行所述计算机可读指令时实现权利要求1至5中任一项所述的高频QRS波形数据分析方法的步骤。
- 一种计算机可读存储介质,其上存储有计算机可读指令,其特征在于,所述计算机可读指令被处理器执行时实现权利要求1至5中任一项所述的高频QRS波形数据分析方法的步骤。
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