WO2023246068A1

WO2023246068A1 - Mass spectrometer use management system and implementation method

Info

Publication number: WO2023246068A1
Application number: PCT/CN2022/143443
Authority: WO
Inventors: 成晓亮; 鲁涵; 徐强; 张伟
Original assignee: 南京品生医疗科技有限公司; 浙江品玉精密科技有限公司
Priority date: 2022-06-21
Filing date: 2022-12-29
Publication date: 2023-12-28
Also published as: CN115204813A

Abstract

The present invention provides a mass spectrometer use management system and an implementation method. At startup, judging whether a detachable card reading module is installed; using a preset transmission method, transmitting user card swiping data to a management system; the management system performing authentication; according to a returned result, judging whether instrument use conditions are satisfied; following completion of instrument use, returning completion information via the preset transmission method, the management system completing registration, and the process being restarted; the invention solves the problems of original manual recording times being inaccurate and not being completed in a timely manner; furthermore, the automated recording process is simple and easy to operate, effectively improves the time efficiency of the user, and allows the user to focus on the use of the instrument.

Description

A mass spectrometer usage management system and implementation method

This application requests the priority of the Chinese patent application submitted to the State Intellectual Property Office on June 21, 2022, with the application number "202210705046.8" and the invention title "A mass spectrometer usage management system and implementation method", all of which The contents are incorporated into this application by reference.

Technical field

The invention relates to the technical field of information management of mass spectrometers, and specifically to a usage management system and implementation method of a mass spectrometer.

Background technique

A mass spectrometer is composed of an ion source, a mass analyzer and an ion detector. The ion source is a device that ionizes sample molecules under high vacuum conditions. The ionized molecules will further fragment into various fragment ions and neutral particles of smaller mass due to receiving too much energy. Fragment ions and neutral particles acquire average kinetic energy with the same energy under the action of an accelerating electric field and enter the mass analyzer. The mass analyzer is a device that separates ions of different masses entering it at the same time according to their mass-to-charge ratio m/e. The separated ions enter the ion detector in sequence, and the amplified ion signals are collected and processed by a computer to draw a mass spectrum. There are many types of ion sources, mass analyzers, and ion detectors. Mass spectrometers are divided into isotope mass spectrometers, inorganic mass spectrometers and organic mass spectrometers according to their application scope; they are divided into high-resolution, medium-resolution and low-resolution mass spectrometers according to their resolving power; they are divided into static instruments and dynamic instruments according to their working principles.

Existing mass spectrometry instruments generally lack the user registration function, or this function has difficulties in accessing third-party management systems and cannot correspond to users one-to-one. This has led to a large number of laboratories using manual methods to record instrument usage logs, which is a waste of time; manual recording The instrument usage log has problems such as untimely recording, inaccurate and untrue results, etc., which causes difficulties in subsequent laboratory management. The relevant mass spectrometry system is relatively closed. The third-party laboratory management system lacks the linkage function with the instrument and cannot accurately record the usage of the instrument and inform whether the instrument is authorized for use.

Contents of the invention

The purpose of the present invention is to provide a usage management system and method for a mass spectrometer to solve problems such as the lack of user registration function, or the difficulty of connecting the function to a third-party management system and the inability to correspond to users one-to-one, resulting in laboratory A large number of manual methods are used to record instrument usage logs, which is a waste of time; manual recording of instrument usage logs has problems such as untimely recording, inaccurate and untrue results, etc., which causes difficulties in laboratory management; the related mass spectrometry system is relatively closed, and third-party experiments The room management system lacks the linkage function with the instruments and cannot accurately record the usage of the instruments and inform whether the instruments are authorized for use.

In a first aspect, the present invention provides a mass spectrometer usage management system, including: a detachable card reader module, a removable wireless data module, a wired data interface, a mass spectrometer instrument control panel, a host computer and a management system;

There is a communication connection between the detachable card reading module and the mass spectrometry instrument control board, the communication connection between the mass spectrometry instrument control board and the removable wireless data module, and the mass spectrometry instrument control board and the host computer. There is a communication connection between computers, the wired data interface is physically connected to the mass spectrometry instrument control panel, the host computer is connected to the management system, the wired data interface is physically connected to the management system, The removable wireless data module is communicatively connected with the management system.

Further, the detachable card reading module has the following characteristics:

The detachable card reading module can be replaced;

The detachable card reading module supports one or more protocols among GB/T 29768, ISO/IEC 14443, ISO/IEC 15693, ISO 18092, and ISO 18000-4, and can read the contents of manual cards;

The detachable card reading module can send the read information to the mass spectrometry system control board.

The removable wireless data module has the following characteristics:

The removable wireless data module can exchange information of the mass spectrometry system and the management system through wireless communication;

The removable wireless data module is detachable, and other functions of the system can still be used after being disassembled.

Further, the wired data interface has the following characteristics:

The wired data interface is used to access a third-party management terminal;

The wired data interface can output mass spectrometry usage information and read the interface access information;

Can be connected to third-party data collection terminals.

The mass spectrometry instrument control panel has the following characteristics:

The mass spectrometry instrument control panel can read the information of each system and control whether the instrument is allowed to operate.

Further, the host computer has the following characteristics:

The host computer can connect with the management system and exchange data;

The host computer can be connected to the mass spectrometry instrument control panel and exchange data.

The management system has the following characteristics:

The management system can record instrument usage information;

The management system can issue a command whether the instrument can be used;

The management system may be a compatible system developed by an authorized third party.

In a second aspect, the present invention provides a method for implementing a mass spectrometer usage management system, including:

Determine whether the removable card reader module is installed when running;

Transmit user card swiping data to the management system through the set transmission method;

Management system for authentication;

Determine whether the instrument usage conditions are met based on the returned results;

After the use of the instrument is completed, the completion information is sent back through the set transmission method, and the management system completes the registration and restarts the process.

Furthermore, determining whether the removable card reader module is installed when starting operation also includes:

If it is installed, wait for the employee to swipe the card. If it is not installed, wait for the installation. After the installation is completed, the employee will swipe the card;

The mass spectrometer control panel performs a card reading operation;

Further, in the step of transmitting the user's card swiping data to the management system through the set transmission method;

Transmission methods include: one or more of detachable wireless modules, wired data interfaces, and host computers;

Further, the management system performs authentication, including:

Determine whether it is a user who can access the system. If it is a user who can use it, the registration operation will be performed. If it is not a user who can use it, registration authorization will not be granted;

After completing the registration, the result will be returned by the set transmission method.

Further, determine whether the instrument usage conditions are met based on the return results, including:

If the result allows the instrument to start, the mass spectrometry instrument control panel starts the instrument; if not, the process starts again.

The beneficial effects of the present invention are as follows: The present invention provides a usage management system and implementation method for a mass spectrometer. By automatically recording usage time, the present invention solves the problem of inaccurate and untimely manual recording of time. At the same time, the automated recording process is simple and easy to operate. , which can effectively improve the time efficiency of users, allowing users to focus on using the instrument itself.

Through cloud authentication operation, the present invention solves the possible authenticity problems of original manual recording users, avoids unauthorized use, and greatly improves the safety of instrument use.

Description of the drawings

In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the drawings needed to be used in the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some of the drawings of the present invention. Embodiments, for those of ordinary skill in the art, other drawings can also be obtained based on these drawings without exerting creative efforts.

Figure 1 is a flow chart of a method for implementing a mass spectrometer usage management system provided by the present invention;

Figure 2 is a general diagram of the implementation method of a mass spectrometer usage management system provided by the present invention;

Figure 3 is a communication connection diagram of a mass spectrometer usage management system provided by the present invention.

Detailed ways

In order to make the purpose, technical solutions and advantages of the present invention more clear, the technical solutions of the present invention will be clearly and completely described below with reference to specific embodiments of the present invention and corresponding drawings. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present invention. The technical solutions provided by various embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

Referring to Figures 1 to 2, an embodiment of the present invention provides a method for implementing a mass spectrometer usage management system, including:

S101: Determine whether the removable card reader module is installed when starting to run.

If the detachable card reading module is installed, wait for the employee to swipe the card. If the detachable card reading module is not installed, wait for the installation. After the installation is completed, the employee will swipe the card. The detachable card reading module can be replaced; the detachable card reading module supports multiple protocols and can read the content of manual cards. It supports multiple protocols to achieve the purpose of reading multiple parties, which is convenient for later use. There are a variety of options for card making, which not only saves a certain amount of costs, but also solves the authenticity problems that may exist for users of the original manual records, avoids unauthorized use, and greatly improves the safety of the instrument;

After the employee swipes the card, the detachable card reading module sends the read information to the mass spectrometer system control board. The mass spectrometer control board detects that the employee swipes the card and performs the card reading operation.

S102: Transmit user card swiping data to the management system through the set transmission method.

The transmission method includes one or more of the detachable wireless module, the wired data interface, and the host computer. The removable wireless data module can exchange information of the mass spectrometry system and the management system through wireless communication. The removable wireless data module is detachable, and other functions of the system can still be used after being disassembled. The wired data interface is used to access a third-party management terminal. The wired data interface can extract and output mass spectrometry usage information, and read the interface access information. The host computer can be connected to the management system and exchange data, and the host computer can be connected to the mass spectrometry instrument control panel and exchange data. The specific use here is: after the mass spectrometry instrument control panel reads the information, it needs to transmit the information to the management system, where the wired data interface can provide wired transmission operations, and the detachable wireless module can implement Wireless transmission, the host computer can complete communication transmission, and a variety of selection methods provide users with more choices, making the system convenient and fast.

S103: Management system performs authentication.

Determine whether the user is able to access the system. If the user is usable, the registration operation will be performed. If the user is not usable, registration authorization will not be granted. A management system is a complete organizational management system composed of various management institutions, management systems, management processes, and management methods with specific management functions and internal connections in order to achieve organizational goals and target management objects. The management system here should have the following main features: the management system can record instrument usage information and register operations; the management system can issue commands whether the instrument can be used.

The management system can record instrument usage information, and the management system can issue a command whether the instrument can be used.

After completing the registration, the results are returned by the set transmission method. The overall operation steps here are: the mass spectrometer control panel collects the information collected by the detachable card reading module through the detachable wireless module, The wired data interface and one or more transmission methods of the host computer are sent to the management system. The management system will judge based on the received information whether it is a user who can access the system. If it is a user who can use it, it will perform the user registration operation, and after granting the right to use, the right to use information will be sent back to the user. Described mass spectrometer control panel, described spectrometer control panel records the time of starting use.

S104: Determine whether the instrument usage conditions are met based on the return results.

If the results allow the instrument to be started, the mass spectrometer instrument control panel starts the instrument.

After the mass spectrometer control panel receives the usage rights information (the mass spectrometer control panel can read each system system information and control whether the instrument is allowed to operate), the mass spectrometer control panel will allow the instrument to operate.

If not allowed, start the process again.

S105: After the use of the instrument is completed, the completion information is returned by the set transmission method, the management system completes the registration, and restarts the process.

Please refer to Figure 3. An embodiment of the invention provides a mass spectrometer usage management system, including: a detachable card reader module, a removable wireless data module, a wired data interface, a mass spectrometer instrument control panel, a host computer, and a management system.

The detachable card reading module is communicatively connected to the mass spectrometry instrument control board. The mass spectrometry instrument control board and the detachable wireless data module are communicated with each other. There is a communication connection between the mass spectrometry instrument control panel and the host computer. The wired data interface is physically connected to the mass spectrometry instrument control board. The host computer is communicatively connected with the management system. The wired data interface is physically connected to the management system. The removable wireless data module is communicatively connected with the management system.

Detachable card reader module 601:

The detachable card reading module can be replaced.

The detachable card reading module supports GB/T 29768 (information technology radio frequency identification 800/900MHz air interface protocol), ISO/IEC 14443 (non-contact IC card standard protocol, close-coupled IC card), ISO/IEC 15693 ( Contactless IC card standard protocol, sparsely coupled IC card), ISO 18092 (near field communication interface protocol), ISO 18000-4 (radio frequency identification RFID standard protocol) one or more protocols, and can be read and used Manual card content.

The specific reference models of the detachable card reader module include but are not limited to: ThingMagic M7e-Pico model.

Mass spectrometry instrument control panel 602:

The mass spectrometry instrument control panel can read the information of each system and control whether the instrument is allowed to operate. The mass spectrometry instrument control panel can be optionally MS-PAN-1200-D2209 (self-developed model).

Removable wireless data module 603:

The removable wireless data module can exchange information of the mass spectrometry system and the management system through wireless communication.

The specific models of the removable wireless data module include but are not limited to ESP32, ESP8266, etc. Here, ESP32 is taken as an example. ESP32 combines antenna switch, RF balun (balun radio frequency), power amplifier, receiving low noise amplifier, filter, and power supply. Management module and other functions are integrated into one. ESP32 requires only a few peripheral components to achieve powerful processing performance, reliable security performance, Wi-Fi and Bluetooth functions. The application here is that the mass spectrometry instrument control board transmits the collected information to the Management system can meet the needs of users.

The wired data interface 604:

The wired data interface is used to access a third-party management terminal.

The wired data interface can extract and output mass spectrometry usage information, and read the interface access information.

It can connect to third-party data collection terminals. The wired data interfaces include but are not limited to: RS232, RS485, CAN, and USB. Here we take the common USB as an example. The USB version has experienced many years of development and has developed into version 3.1, becoming the second version. The standard expansion interface in eleventh-century computers. Currently, motherboards mainly use USB2.0 and USB3.0 interfaces, and various USB versions are well compatible. USB uses a 4-pin (USB3.0 standard is 9-pin) plug as the standard plug. All peripherals can be connected in a daisy chain form. Up to 127 external devices can be connected without losing bandwidth. USB requires support from three aspects: host hardware, operating system and peripherals to work. The motherboard generally uses a control chipset that supports USB functions. The motherboard is also equipped with a USB interface socket. In addition to the socket on the back panel, the motherboard also has USB pins reserved, which can be connected to the front of the chassis as a front panel. Set up USB interface for convenient use. Moreover, the USB interface can also realize the interconnection of two machines through a special USB connection cable, and can expand more interfaces through the Hub. The application of USB here is to connect to a third-party management terminal to extract and output mass spectrometry usage information. , and read the interface access information.

The host computer 605:

The host computer can connect with the management system and exchange data.

Management system 606:

The management system can record instrument usage information, including: user information, used for authorization, usage start time, usage end time, and recording usage duration, which can effectively improve the time efficiency of users and allow users to focus on using the instrument itself. .

The management system can issue a command whether the instrument can be used.

Principle of use: Determine whether the detachable card reading module is installed when it starts running. If it is installed, wait for the employee to swipe the card. If not, wait for the installation. After the installation is completed, the employee will swipe the card. The mass spectrometer control panel performs a card reading operation and transmits the user's card swiping data to the management system through the set transmission method. The management system authenticates and determines whether the user is a user who can access the system. If it is a user who can use it, then Registration operation, if the user is not available, registration authorization will not be granted. After completing the registration, the result will be returned by the set transmission method. Based on the return result, it will be determined whether the instrument usage conditions are met. If the result allows the instrument to be started, the mass spectrometer instrument will control The board starts the instrument. After the instrument is used, the completion information is sent back through the set transmission method. The management system completes the registration and restarts the process.

Those skilled in the art can clearly understand that the technology in the embodiments of the present invention can be implemented by means of software plus the necessary general hardware platform. Based on this understanding, the technical solutions in the embodiments of the present invention can be embodied in the form of software products in essence or those that contribute to the existing technology. The computer software products can be stored in storage media, such as ROM/RAM. , magnetic disk, optical disk, etc., including a number of instructions to cause a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods described in various embodiments or certain parts of the embodiments of the present invention.

The above-described embodiments of the present invention do not limit the scope of the present invention.

Claims

A usage management system for a mass spectrometer, which is characterized by including: a detachable card reader module, a detachable wireless data module, a wired data interface, a mass spectrometer instrument control panel, a host computer and a management system;

There is a communication connection between the detachable card reading module and the mass spectrometry instrument control board, the communication connection between the mass spectrometry instrument control board and the removable wireless data module, and the mass spectrometry instrument control board and the host computer. There is a communication connection between computers, the wired data interface is physically connected to the mass spectrometry instrument control panel, the host computer is connected to the management system, the wired data interface is physically connected to the management system, The removable wireless data module is communicatively connected with the management system.
A mass spectrometer usage management system according to claim 1, characterized in that:

The detachable card reading module can be replaced;

The detachable card reading module supports one or more protocols among GB/T 29768, ISO/IEC 14443, ISO/IEC 15693, ISO 18092, and ISO 18000-4, and is used to read the content of manual cards;

The detachable card reading module can send the read information to the mass spectrometry system control board;

The removable wireless data module is used to exchange information of the mass spectrometry system and the management system through wireless communication;

The removable wireless data module is detachable, and other functions of the system can still be used after being disassembled.
A mass spectrometer usage management system according to claim 1, characterized in that:

The wired data interface is used to access a third-party management terminal;

The wired data interface is used to output mass spectrometry usage information and read the interface access information;

The wired data interface is also used to connect third-party data collection terminals;

The mass spectrometry instrument control panel is used to read information of each system and control whether the instrument is allowed to operate.
A mass spectrometer usage management system according to claim 1, characterized in that:

The host computer is used to connect with the management system and exchange data;

The host computer is also used to connect with the mass spectrometry instrument control board and exchange data;

The management system is used to record instrument usage information;

The management system is also used to issue commands whether the instrument can be used;

The management system is also used in compatible systems developed for authorized third parties.
A method for implementing a mass spectrometer usage management system, applied to the mass spectrometer usage management system according to any one of claims 1 to 4, characterized in that it includes:

Determine whether the removable card reader module is installed when running;

Transmit user card swiping data to the management system through the set transmission method;

Management system for authentication;

Determine whether the instrument usage conditions are met based on the returned results;

After the use of the instrument is completed, the completion information is sent back through the set transmission method, and the management system completes the registration and restarts the process.
The method for implementing a mass spectrometer usage management system according to claim 5, characterized in that, when starting operation, it is determined whether the detachable card reading module is installed, and further includes:

If it is installed, wait for the employee to swipe the card. If it is not installed, wait for the installation. After the installation is completed, the employee will swipe the card;

The mass spectrometer control panel performs a card reading operation.
A method for implementing a mass spectrometer usage management system according to claim 5, characterized in that in the step of transmitting user card swiping data to the management system through a set transmission method;

The transmission method includes one or more of detachable wireless modules, wired data interfaces, and host computers.
A method for implementing a mass spectrometer usage management system according to claim 5, characterized in that the management system performs authentication, including:

Determine whether it is a user who can access the system. If it is a user who can use it, the registration operation will be performed. If it is not a user who can use it, registration authorization will not be granted;

After completing the registration, the result will be returned by the set transmission method.
A method for implementing a mass spectrometer usage management system according to claim 5, characterized in that determining whether instrument usage conditions are met based on the return results includes:

If the result allows the instrument to start, the mass spectrometry instrument control board starts the instrument;

If not allowed, start the process again.