WO2023233441A1 - Système et procédé d'actionnement d'une seringue - Google Patents

Système et procédé d'actionnement d'une seringue Download PDF

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Publication number
WO2023233441A1
WO2023233441A1 PCT/IT2023/050139 IT2023050139W WO2023233441A1 WO 2023233441 A1 WO2023233441 A1 WO 2023233441A1 IT 2023050139 W IT2023050139 W IT 2023050139W WO 2023233441 A1 WO2023233441 A1 WO 2023233441A1
Authority
WO
WIPO (PCT)
Prior art keywords
slider
syringe
plunger
reference element
base body
Prior art date
Application number
PCT/IT2023/050139
Other languages
English (en)
Inventor
Luca Giorgini
Alessandro Balboni
Original Assignee
Plan 1 Health S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plan 1 Health S.R.L. filed Critical Plan 1 Health S.R.L.
Publication of WO2023233441A1 publication Critical patent/WO2023233441A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31536—Blocking means to immobilize a selected dose, e.g. to administer equal doses
    • A61M2005/3154—Blocking means to immobilize a selected dose, e.g. to administer equal doses limiting maximum permissible dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member

Definitions

  • the present invention can be applied in the healthcare field and concerns a device and a method for driving, in a very precise and controlled manner, a syringe for feeding homogeneous liquid solutions or dispersions, even with high viscosity, of synthetic or natural origin, such as chemical preparations, drugs, nutrients, or suchlike (collectively here and in the claims defined as “liquid substance”), in infusion devices, such as infusion bags, or elastomeric pumps, usable in more complex infusion systems to perform pharmacological treatments, for example chemotherapy treatments.
  • infusion devices such as infusion bags, or elastomeric pumps
  • infusion systems In the healthcare field, in order to carry out pharmacological treatments on patients, infusion systems are normally used, provided with respective infusion devices which are fed with a specific liquid substance.
  • these infusion devices are filled manually by a healthcare professional by means of a graduated syringe, for example of 50 or 60 ml, which is first connected to a container, or bag, containing the specific liquid solution, in order to suction a determinate quantity, and then to the infusion device, so as to fill it with the same quantity of suctioned liquid solution.
  • a graduated syringe for example of 50 or 60 ml
  • liquid solutions are used, even very viscous ones, which have to be inserted into particular elastomeric pumps, essentially balloon-shaped, in which the elastomer, or elastomeric material, has a high modulus of elasticity which has to be overcome by the pressure exerted by the liquid substance to be inserted into the pump, which inflates it up to a known volume which has to be respected with precision.
  • both the operation of suctioning the liquid solution and also the filling operation can be difficult and not very precise, since the force that the operator has to exert through the plunger of the syringe has to be able to overcome both the resistance of the liquid solution and also the resistance of the elastomer of the infusion devices.
  • liquid solutions used in chemotherapy treatments are very expensive and have a high risk of contamination and chemical degradation, therefore the operator who performs the operations manually has to be highly specialized and pay the utmost attention during the operation.
  • Document US 2021/275751 describes a stop device for a plunger of a standard syringe to administer a standard liquid substance in a controlled manner, in which the syringe is supported and driven directly by hand by an operator.
  • the stop device comprises a base which rests against the flange of a finger of the operator, and a plurality of removable rings cooperating with a terminal end of the plunger to select different delivery intervals.
  • Electronic apparatuses which allow to perform the dosing and filling operations of the infusion devices in a programmable and computerized manner by acting on a graduated syringe, pre-filled manually by an operator, with the disadvantages as above.
  • these known apparatuses are very expensive, so that many hospitals or doctors’ surgeries do not have them.
  • one purpose of the present invention is to provide a device and perfect a method for driving a syringe which allows to deliver a desired quantity of liquid substance in a very precise manner, without this depending on the skill or capacity of the operator.
  • Another purpose of the present invention is to provide a device and perfect a method for driving a syringe which allows to simplify and speed up the dosing and feeding operations of a liquid substance in the infusion devices.
  • Another purpose of the present invention is to provide a device and perfect a method for driving a syringe which is simple, and which does not require excessive manual effort on the part of the operator.
  • Another purpose of the present invention is to provide a device for driving a syringe which is easy and cheap to produce.
  • the Applicant has devised, tested and embodied the present invention to overcome the shortcomings of the state of the art and to obtain these and other purposes and advantages.
  • a device for driving a plunger of a syringe having a body capable of containing a determinate quantity of a liquid substance, even with high viscosity, and in which at least a part of the plunger is sliding.
  • the device comprises a base body configured to support the body, a slider configured to cooperate with a terminal end of the plunger and sliding linearly with respect to the base body in both directions between a first position, defined by a reference element of the base body, and a second position, distant from the reference element, and drive means for driving the slider between the first and second position, also making the plunger slide easily.
  • the base body comprises a base plate for stably resting the device on a suitable rest plane, the reference element having at least one part transverse to the base plate.
  • the device has the advantage of driving, even continuously, the plunger of the syringe without making considerable effort.
  • the elastomer of the elastomeric pumps has a very high elastic coefficient, which has to be overcome with the drive of the syringe, the direct manual action on the plunger would be very tiring and such that it would not allow to easily manage the steps of suction and emptying of the syringe itself.
  • the base plate is conformed in such a way as to have at least one longitudinal cavity in which the hand of an operator, or other suitable locking mean, can be positioned or inserted in order to keep the device stationary and in contact with the rest plane.
  • the reference element comprises, or consists of, a first upright provided with a first seating in which the body of the syringe can be at least partly positioned.
  • the slider being provided with a second seating in which the terminal end can be inserted.
  • the base body also comprises a second upright parallel to the first upright and configured to define the second position of the slider.
  • the guide means being associated on one side with the first upright and on the other side with the second upright.
  • the handling member is able to pass from an open position, in which the slider is in the second position, to a closed position, in which the slider is in the first position, and vice versa.
  • the handling member comprises at least one lateral arm which is pivoted to the base plate, connected to the slider by means of a connection pin and provided with a handle.
  • the reference element at an opposite end thereof with respect to the first upright, is pivoted to the base plate so that is capable of inclining with respect to it by a determinate angle in relation to the movement of the handling member, wherein when the handling member is in the open position the reference element is in contact with the base plate and when the handling member is in the closed position the reference element is inclined with respect to the base plate.
  • the base body also comprises a second upright parallel to the first upright and configured to define the second position of the slider.
  • the guide means are associated on one side with the first upright and on the other side with the second upright.
  • the handling member comprises one or more lateral arms pivoted to the second upright and, on the opposite side, connected to a handle.
  • mobile stop means able to be selectively positioned between said positions in order to define an effective travel of the slider and therefore of the plunger with respect to the body.
  • the mobile stop means comprise one or more stop modules, each having a determinate thickness corresponding to a fraction of the travel of the slider and equivalent to a determinate and precise volumetric quantity of the syringe.
  • the one or more stop modules can be positioned on the base body in a removable manner, adjacent to each other when there are at least two of them, along the movement path of the slider, whereby the extension of the effective travel is equal to the difference between the travel and the overall thickness of the one or more stop modules, the latter acting as travel-limiting devices.
  • each of the stop modules can be positioned, in a condition of delivery of the syringe, between the reference element and the slider, and in a condition of suction of the syringe, in such a way that the slider is interposed between them and the reference element.
  • each of the stop modules comprises a calibrated block provided with coupling elements of the male-female type with reciprocally mating shapes, made on opposite sides and able to be coupled to each other in a removable manner.
  • each of the stop modules is provided with at least one stabilization element associated with the guide means and configured to stabilize the respective stop module with respect to the base body.
  • the base body is provided with one or more positioning seatings, in each of which one of the stop modules is able to be inserted.
  • the present invention also concerns a method for driving a plunger of a syringe by means of a drive device, which comprises a preparation step in which a body of the syringe is disposed on, or in correspondence with, a reference element of a base body of the device, in which the syringe is connected to an infusion system in which a liquid substance, even with high viscosity, circulates, and in which a terminal end of the plunger is associated with a slider sliding linearly with respect to the base body in both directions between a first position, defined by the reference element, and a second position, distant from the reference element.
  • the method also comprises one or more operating steps in which drive means drive the slider between the first and second position, also making the plunger slide easily, the base body comprising a base plate for stably resting the device on a suitable rest plane during the execution of the one or more operating steps.
  • mobile stop means are able to be selectively positioned between the first and second position in order to define an effective travel of the slider and therefore of the plunger with respect to the body, thus determining with precision the quantity of the liquid substance suctioned into, or delivered from, the syringe.
  • the operating steps comprise one or the other of either a step of delivering the liquid substance, in which the slider is initially in the second position and in which the one or more stop modules are positioned on the base body, one adjacent to the other when there are at least two of them, between the reference element and the slider, and a step of controlled suction, in which the slider is initially in the first position and in which one or more stop modules are positioned on the base body, one adjacent to the other when there are at least two of them, in such a way that the slider is interposed between the reference element and the one or more stop modules, in order to define, in both cases, the effective travel.
  • the device is provided for use in said method for driving a plunger.
  • - fig. 1 is a three-dimensional view of a device for driving a syringe, according to the present invention
  • - fig. 2 is another a three-dimensional view of the device of fig. 1, without the syringe;
  • - figs from 3 to 5 are a schematic representation of a delivery step using the device of fig. 1;
  • - figs from 6 to 8 are a schematic representation of a suction step using the device of fig. 1 ;
  • - fig. 9 is a three-dimensional view of a device for driving a syringe according to another embodiment of the present invention, in a first operating condition;
  • - fig. 10 is a three-dimensional view of the device for driving a syringe of fig. 9, in a second operating condition.
  • a device 10 according to the present invention is suitable and able to be used to drive, in a controlled and precise manner, a syringe
  • a plunger, or piston, 103 thereof for the dosed feed of a homogeneous liquid solution, or dispersion, even with high viscosity, as indicated above, in a corresponding infusion device, which can be of any known type whatsoever, or one which will be developed in the future and which is not shown in the drawings, such as an infusion bag or an elastomeric pump.
  • the infusion device can be used, for example, in any infusion system whatsoever, also not shown in the drawings, usable, for example, in chemotherapy treatments. It is known that some liquid substances used in such infusion devices or systems have a high viscosity, which makes the manual drive of the plunger 103 of the syringe 100 very difficult or tiring.
  • the syringe 100 can be substantially of any known type whatsoever for the use described above, and essentially comprises a hollow cylindrical body
  • the plunger 103 comprises an internal end 104 provided with a sealing rubber sliding inside the body 101 and an external terminal end 105, opposite to the internal one 104.
  • the device 10 is configured to drive the plunger 103 of the syringe 100 in order to displace it between a position of maximum suction of the liquid substance, in which it is almost entirely outside the body 101, leaving substantially only the internal end 104 with the sealing rubber inside the body 101, and a position of maximum delivery in which it is almost entirely inside the body 101, leaving substantially only the terminal end 105 outside.
  • the device 10 comprises a base body 11 having a substantially horizontal base plate 12, for resting the device 10 stably on any rest plane, and a reference element 14 mounted thereon.
  • the reference element 14 is fixed and consists of a first upright 13 transverse, for example perpendicular, to the base plate 12.
  • the base body 11 can also be provided with a second upright 15, parallel to the first upright 13 and also perpendicular to the base plate 12.
  • the base plate 12 is conformed so as to have at least one longitudinal cavity 18 in which the hand of an operator, or another suitable locking mean, can be inserted in order to keep the device 10 stationary and in contact with the rest plane.
  • the longitudinal cavity 18 is made through.
  • the reference element 14 is substantially L-shaped and comprises the first upright 13. Moreover, the reference element 14, in correspondence with an end thereof opposite to the first upright 13, is pivoted to the plate 12 in such a way as to be inclined with respect to it.
  • the first upright 13 is provided with a first seating 16 in which a rear terminal part of the body 101 of the syringe 100 can be positioned in a removable manner (figs. 1, 3 and 6).
  • a locking bar 40 is pivoted on the upper part of the first upright 13 (figs. 1 and 2) to selectively and temporarily lock the body 101 in the first seating 16.
  • the device 10 also comprises a slider 17 sliding linearly with respect to the base body 11, which is configured to support and cooperate with the terminal end 105 of the plunger 103, moving it.
  • the slider 17 is provided with a second seating 19 in which the terminal end 105 of the plunger 103 is inserted with minimal play.
  • the first seating 16 and the second seating 19 are made in such a way that the syringe 100 is disposed parallel to the base plate 12.
  • the slider 17 is able to slide along an axis of sliding X, parallel to the base plate 12, between a first position Pl, in which it is proximal to the first upright 13, and a second position P2, in which it is distal from the first upright 13 and located up against the second upright 15.
  • first position Pl the plunger 103 is in the position of maximum delivery
  • second position P2 the plunger 103 is in the position of maximum suction.
  • the device 10 comprises drive means 24 for driving the slider 17 between the first position Pl and the second position P2, thus also making the plunger 103 of the syringe 100 slide without particular effort, as will be described in detail below.
  • first upright 13 defines the reference limit during a step of delivery of the liquid substance and the second upright 15 defines the reference limit during a step of suction of the liquid substance, as will be described in detail below.
  • the device 10 is also provided with guide means 20 which are associated at least with the first upright 13, which have the function of guiding and supporting the slider 17 during its travel C.
  • the guide means 20 are associated on one side with the first upright 13 and on the other side with the second upright 15.
  • the guide means 20 are defined by two guides 20a and 20b which are coplanar to each other, parallel to the base plate 12 and distanced therefrom.
  • the two guides 20a and 20b are attached to the first upright 13 and to the second upright 15.
  • the slider 17 is provided with two through holes, made in its lower part, which cooperate sliding with said two guides 20a and 20b.
  • the guide means 20 can be defined by rails, or other suitable means, for example disposed parallel to each other on the base plate 12.
  • the guide means 20 are defined by two guides 20a, 20b which are coplanar to each other, parallel to the base plate 12 and distanced therefrom.
  • a first end of the two guides 20a, 20b is able to cooperate with the reference element 14 and a second end of the two guides 20a, 20b is able to cooperate with the slider 17.
  • the first end of the guides 20a, 20b can be attached to the first upright 13 and the slider 17 is able to slide along them between the first and second position Pl, P2.
  • the second end of the guides 20a, 20b can be attached to the slider 17 and they are able to slide inside the reference element 14 in order to make the slider 17 pass from the first to the second position Pl, P2 (fig. 10).
  • the device 10 also comprises a handling member 23 configured to make the slider 17 slide along the guide means 20, that is, the guides 20a and 20b between the first position P 1 and the second position P2, and vice versa.
  • the handling member 23 defines the drive means 24 of the slider 17.
  • the handling member 23 comprises two lateral arms 25 parallel to each other which, in correspondence with the respective lower ends, are pivoted to the second upright 15 and which, in correspondence with the respective upper ends, are connected to each other by means of a handle 26.
  • the two lateral arms 25 are connected to the slider 17 by means of respective intermediate arms 27 which are also parallel to each other and disposed on opposite sides with respect to the slider 17. Specifically, the intermediate arms 27 are pivoted at one end to the respective lateral arms 25, while at the other end they are pivoted in correspondence with respective lateral recesses 29 created in an upper part of the slider 17.
  • the handling member 23 comprises a single lateral arm 25 provided with a handle 26.
  • the arm 25 can be pivoted to the base plate 12, the disposition of the second upright 15 not being provided, and connected to the slider 17 by means of a connection pin 28.
  • the reference element 14 when the handling member 23 is in the open position PA, the reference element 14 is in contact with the base plate 12 (fig. 9), instead when the handling member 23 is in the closed position PC, the reference element 14 is inclined by a determinate angle with respect to the base plate 12 (fig. 10). Please note that fig. 10 approximately shows the closed position PC so that the movement of the reference element 14 can be better understood.
  • the handling member 23 is able to incline with respect to the base body 11 , rotating around an axis of rotation R perpendicular to the axis of sliding X, in order to pass from a closed position PC, in which the slider 17 is located in the first position Pl and, consequently, the plunger 103 is in the position of maximum delivery, to an open position PA, in which the slider 17 is in the second position P2 and, consequently, the plunger 103 is in the position of maximum suction.
  • the handling member 23 performs the function of a lever of the first type and allows to drive the plunger 103 of the syringe 100 with precision and without requiring particular efforts on behalf of an operator, which would otherwise be necessary given the presence of liquid substances in the syringe 100, even with high viscosity, which have to overcome the elastic resistance of an elastomer with a high elastic coefficient present in the elastomeric pumps, in order to be able to inject a desired volume of liquid substance inside them.
  • the device 10 can be provided with mobile stop elements, or means, 30 which are able to be selectively positioned between the first and second position Pl, P2 in order to define an effective travel CE of the slider 17, and therefore the position of the plunger 103 with respect to the body 101, in order to thus precisely control the quantity of liquid substance suctioned into, or delivered from, the syringe 100.
  • the mobile stop means 30 comprise a plurality of stop modules, or calibrated blocks, 30i, each of which has a determinate thickness S corresponding to a fraction of the travel C of the slider 17 and equivalent to a determinate and precise volumetric quantity of the syringe 100, and therefore of the liquid substance to be introduced into, or delivered from, said syringe 100, for example a few milliliters.
  • the thickness S is determined, or defined, in correspondence with a head, or upper, portion 31 of each stop module 30i.
  • the stop modules 30i can be positioned on the base body 11 in a removable manner, adjacent to each other and without a break in continuity when there are at least two of them, along the path of the slider 17, in order to define the effective travel CE of the latter.
  • the effective travel CE is given by the difference between the travel C and the overall thickness of the stop modules 3 Oi disposed along the path of the slider 17; the stop modules 3 Oi acting as intermediate travellimiting devices.
  • the mobile stop means 30 can all be removed from the base body 11, or they can also not be provided.
  • the syringe 100 is configured to contain 60 ml of liquid substance and there are six stop modules 30i, each having a thickness S equivalent to exactly 10 ml of liquid substance. It is understood that in other embodiments, not shown in the drawings, the syringe 100 can be configured to contain a different quantity of liquid substance; moreover, also the thickness S and/or the number of stop modules 30i can be modified with respect to those described, thus defining other volumetric quantities, or intervals, for each of them.
  • each stop module 30i comprises coupling elements 33, 35 (fig. 1) of the male- female type having reciprocally mating shapes, created on opposite sides and able to be coupled to each other in a removable manner.
  • the coupling elements 33, 35 are defined, respectively, by protrusions 33 and corresponding recesses 35, created on opposite sides and having reciprocally mating shapes in order to guarantee a suitable coupling between them, and therefore between two adjacent stop modules 30i.
  • the protrusions 33 and the recesses 35 have a mating rectangular shape, but in other embodiments they could be of a different shape, for example a dovetail shape.
  • the thickness S of each stop module 3 Oi is determined without taking into account the coupling elements 33, 35.
  • each stop module 30i is also provided with a pair of stabilization elements 36, 37 (fig. 2) which are configured to stabilize its coupling to the base body 11.
  • the stabilization elements comprise an upper groove 36 created in correspondence with the head portion 31 and configured to cooperate with the guide 20a, and a hook 37 configured to fasten, for example in a snap-in manner, to a longitudinal groove 39 created on the base plate 12.
  • each stop module 3 Oi in correspondence with the upper groove 36, could be provided with a hook configured to fasten, for example in a snap-in manner, to the guide 20a.
  • each stop module 30i is able to be inserted with a lower part thereof.
  • the first upright 13, in correspondence with one side thereof, is shaped in such a way as to have a recess 34 that is the same as the recesses 35 and mating with the protrusions 33 of the stop modules 30i, thus allowing to correctly position any one of the stop modules 30i (figs. 3, 6, 7 and 8).
  • the stop modules 30i can be disposed according to different modes and/or needs, and their number varies in relation to the quantity of liquid substance to be delivered, or suctioned, by means of the syringe 100.
  • the slider 17 is initially located in the second position P2 (figs. 3 and 4) and the stop modules 30i are disposed one adjacent to the other without a break in continuity, between the first upright 13 and the slider 17.
  • the slider 17 is initially located in the first position Pl (figs. 6 and 7) and the stop modules 30i are disposed one adjacent to the other without a break in continuity, between the slider 17 and the second upright 15, starting from the latter.
  • a locking bar 40 is pivoted on the upper part of the first upright 13 (figs. 1 and 2) which is configured to selectively open and close for the purpose of disposing and, respectively, preventing the accidental removal or lifting of, the body 101 from the first seating 16.
  • an electromechanical drive member in order to move the slider 17 between the first position Pl and the second position P2, instead of the handling member 23, an electromechanical drive member can be provided, for example by means of a stepping motor or by means of an electrically driven linear actuator, in combination with suitable mechanical means such as cams or connection rods. In this case, it is the drive member that defines the drive means 24.
  • the electromechanical drive member can be provided in combination with the stop means 30, or, alternatively, without the presence thereof.
  • the embodiments described with reference to figs. 9 and 10 may not provide the stop means 30.
  • electromechanical drive member so that the sliding of the slider 17 occurs according to pre-established intervals of forward or backward movement.
  • one or more detection sensors can also be provided, which allow to verify the correct position of the slider 17 in relation to the pre-established sliding intervals.
  • the syringe 100 in correspondence with the internal end of the body 101, can be provided with a Luer-type connector, known to the persons of skill in the art and not shown in the drawings, so that it can couple to a feed line of the infusion system mentioned above, which comprises, or consists of, a flexible tube, the feed line can be provided, at inlet, with a three-way regulator, or cock, also known to the persons of skill in the art and not shown in the drawings, which allows to selectively connect the syringe 100 first to a bag containing the specific high viscosity liquid solution to be suctioned, and then to the infusion device to be filled. In this way, an operator, by acting selectively on the three-way cock, can continuously suction and deliver a precise volumetric quantity of the liquid substance, achieving a considerable advantage compared to the state of the art.
  • a Luer-type connector known to the persons of skill in the art and not shown in the drawings
  • the operation of the device 10 described heretofore which corresponds to the method according to the present invention, comprises the following steps. Initially, the device 10 is not provided with the syringe 100 (fig. 2) and the locking bar 40 is open to allow the syringe 100 to be introduced later.
  • the syringe 100 is positioned on the device 10 so that the terminal part of the body 101 is disposed in the first seating 16 and that the terminal end 105 of the plunger 103 is inserted in the second seating 19 of the slider 17.
  • the device 10 is not provided with the mobile stop means 30 and the syringe 100 is connected to a bag containing the high viscosity liquid substance, possibly by acting on the three-way cock connected to the infusion system.
  • the handling member 23 is inclined from the closed position PC to the open position PA so as to make the slider 17 slide from the first position Pl to the second position P2 and thus suction, into the body 101, a determinate quantity of liquid substance, even with high viscosity, equal to the maximum containing capacity of the syringe 100.
  • the syringe 100 is connected to an infusion device of the infusion system in which the liquid substance circulates.
  • one or more stop modules 30i are disposed in sequence between the first upright 13 and the slider 17 in order to define the effective travel CE of the slider 17 for the filling condition
  • the number of stop modules 30i disposed on the base body 11 determines the quantity of liquid substance delivered through the syringe 100.
  • the handling member 23 is inclined in order to pass from the open position PA to a determinate intermediate position, thus making the slider 17 slide from the second position P2 to an intermediate operating position, in which it abuts against the stop module 30i facing toward it (fig. 5). In this way, a precise volume of liquid substance is delivered from the syringe 100 into the infusion device.
  • each stop module 30i is equivalent to 10 ml of liquid substance
  • the method also provides an operating step of controlled suction, for example in the event the entire content of the syringe 100 is delivered, in which initially, by acting on the three-way cock, the syringe 100 is connected to a bag containing the liquid substance, even with high density.
  • the handling member 23 is in the closed position PC and the slider 17 is located in the first position Pl (fig. 6).
  • one or more stop modules 3 Oi are disposed in sequence between the slider 17 and the second upright 15, starting from the latter, so as to define the effective travel CE for the condition of suction (fig. 7).
  • the handling member 23 is then inclined in order to pass from the closed position PC to a determinate intermediate position, thus causing the slider 17 to slide from the first position Pl to an intermediate operating position, in which it abuts on the stop module 30i closest to it (fig. 8). In this way, a precise volumetric quantity of liquid substance is suctioned into the syringe 100.
  • the reference element 14 inclines by a determinate angle with respect to the base plate 12, and the slider 17 passes from the second position P2 to the first position Pl (fig. 10).
  • the reference element 14 lowers until it contacts the base plate 12 again, and the slider 17 passes from the first position Pl to the second position P2 (fig.9).
  • the stop modules 3 Oi can be made in such a way that they can be positioned, in a removable manner, astride the guide means 20, adjacent to each other when there are at least two of them, along the path of the slider 17, in order to define the effective travel CE of the latter.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Dispositif (10) pour actionner un piston (103) d'une seringue (100) ayant un corps (101) pouvant contenir une quantité déterminée de substance liquide et dans lequel au moins une partie du piston (103) peut coulisser. Le dispositif (10) comprend un corps de base (11) ayant un élément de référence (14), un coulisseau (17) conçu pour coopérer avec une extrémité terminale (105) du piston (103) et qui coulisse linéairement par rapport au corps de base (11), et des moyens d'actionnement (24) pour actionner le coulisseau (17) entre lesdites première (Pl) et seconde (P2) positions, faisant également coulisser facilement ledit piston (103).
PCT/IT2023/050139 2022-06-01 2023-05-30 Système et procédé d'actionnement d'une seringue WO2023233441A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102022000011618A IT202200011618A1 (it) 2022-06-01 2022-06-01 Dispositivo e procedimento per azionare una siringa
IT102022000011618 2022-06-01

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WO2023233441A1 true WO2023233441A1 (fr) 2023-12-07

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170296753A1 (en) * 2016-04-18 2017-10-19 Accunit, Llc Handheld medical substance dispensing system, apparatus and methods
US20190269857A1 (en) * 2016-11-21 2019-09-05 Merck Sharp & Dohme Corp. Manually-Actuated Injection Device for High-Viscosity Drugs
US20190381252A1 (en) * 2018-06-19 2019-12-19 Innomed Technologies, Inc. Precision low-dose,low-waste syringes and ergonomic attachments therefor
US20210275751A1 (en) * 2016-11-04 2021-09-09 Shire Human Genetic Therapies, Inc. Small unit dosage plunger rod stops

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170296753A1 (en) * 2016-04-18 2017-10-19 Accunit, Llc Handheld medical substance dispensing system, apparatus and methods
US20210275751A1 (en) * 2016-11-04 2021-09-09 Shire Human Genetic Therapies, Inc. Small unit dosage plunger rod stops
US20190269857A1 (en) * 2016-11-21 2019-09-05 Merck Sharp & Dohme Corp. Manually-Actuated Injection Device for High-Viscosity Drugs
US20190381252A1 (en) * 2018-06-19 2019-12-19 Innomed Technologies, Inc. Precision low-dose,low-waste syringes and ergonomic attachments therefor

Also Published As

Publication number Publication date
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