WO2023230481A8 - Orthopoxvirus vaccines - Google Patents

Orthopoxvirus vaccines Download PDF

Info

Publication number
WO2023230481A8
WO2023230481A8 PCT/US2023/067368 US2023067368W WO2023230481A8 WO 2023230481 A8 WO2023230481 A8 WO 2023230481A8 US 2023067368 W US2023067368 W US 2023067368W WO 2023230481 A8 WO2023230481 A8 WO 2023230481A8
Authority
WO
WIPO (PCT)
Prior art keywords
vaccines
orthopoxvirus
orthopoxvirus vaccines
orthopoxviruses
monkeypox
Prior art date
Application number
PCT/US2023/067368
Other languages
French (fr)
Other versions
WO2023230481A1 (en
Inventor
Gwo-yu CHUANG
Mihir METKAR
Original Assignee
Modernatx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx, Inc. filed Critical Modernatx, Inc.
Publication of WO2023230481A1 publication Critical patent/WO2023230481A1/en
Publication of WO2023230481A8 publication Critical patent/WO2023230481A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

The disclosure provides mRNA vaccines for orthopoxviruses, such as smallpox and monkeypox, as well as methods of using the vaccines.
PCT/US2023/067368 2022-05-24 2023-05-23 Orthopoxvirus vaccines WO2023230481A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202263345390P 2022-05-24 2022-05-24
US63/345,390 2022-05-24
US202263395567P 2022-08-05 2022-08-05
US63/395,567 2022-08-05

Publications (2)

Publication Number Publication Date
WO2023230481A1 WO2023230481A1 (en) 2023-11-30
WO2023230481A8 true WO2023230481A8 (en) 2024-01-25

Family

ID=86776294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/067368 WO2023230481A1 (en) 2022-05-24 2023-05-23 Orthopoxvirus vaccines

Country Status (1)

Country Link
WO (1) WO2023230481A1 (en)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1832603B1 (en) 2001-06-05 2010-02-03 CureVac GmbH Stabilised mRNA with increased G/C-content encoding a bacterial antigen and its use
US9012219B2 (en) 2005-08-23 2015-04-21 The Trustees Of The University Of Pennsylvania RNA preparations comprising purified modified RNA for reprogramming cells
DE102005046490A1 (en) 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz New nucleic acid molecule comprising promoter, a transcriptable nucleic acid sequence, a first and second nucleic acid sequence for producing modified RNA with transcriptional stability and translational efficiency
JP2010531640A (en) 2007-06-29 2010-09-30 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼイション Method for decomposing toxic compounds
EP2535419A3 (en) 2007-09-26 2013-05-29 Intrexon Corporation Synthetic 5'UTRs, expression vectors, and methods for increasing transgene expression
CN103911378A (en) 2007-12-11 2014-07-09 斯克利普斯研究所 Compositions and methods related to mRNA translational enhancer elements
KR20220025112A (en) 2011-06-08 2022-03-03 샤이어 휴먼 지네틱 테라피즈 인크. Lipid nanoparticle compositions and methods for mrna delivery
CA2876155C (en) 2012-06-08 2022-12-13 Ethris Gmbh Pulmonary delivery of mrna to non-lung target cells
WO2014144196A1 (en) 2013-03-15 2014-09-18 Shire Human Genetic Therapies, Inc. Synergistic enhancement of the delivery of nucleic acids via blended formulations
RU2733424C2 (en) 2013-08-21 2020-10-01 Куревак Аг Method for increasing the expression of encoded rna proteins
CA2925021A1 (en) 2013-11-01 2015-05-07 Curevac Ag Modified rna with decreased immunostimulatory properties
CA2927254C (en) 2013-12-30 2023-10-24 Curevac Ag Artificial nucleic acid molecules
RU2717986C2 (en) 2013-12-30 2020-03-27 Куревак Аг Artificial molecules of nucleic acid
US20210206818A1 (en) 2016-01-22 2021-07-08 Modernatx, Inc. Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
CN111212905A (en) 2017-08-18 2020-05-29 摩登纳特斯有限公司 RNA polymerase variants
AU2020224103A1 (en) 2019-02-20 2021-09-16 Modernatx, Inc. Rna polymerase variants for co-transcriptional capping

Also Published As

Publication number Publication date
WO2023230481A1 (en) 2023-11-30

Similar Documents

Publication Publication Date Title
AU2022208057A9 (en) Variant strain-based coronavirus vaccines
WO2022155530A8 (en) Variant strain-based coronavirus vaccines
WO2018089261A3 (en) Compounds and methods for modulating interleukin-2-inducible t-cell kinase
EP3870217A4 (en) Mutant vaccinia viruses and use thereof
WO2022221335A8 (en) Respiratory virus combination vaccines
EP3856825A4 (en) Ion exchange membrane through uv initiated polymerization
WO2018228538A9 (en) Recombinant herpes simplex virus, preparation method therefor, and application thereof
EP3998246A4 (en) Nitride high-entropy ceramic fiber, preparation method thereof, and application thereof
WO2017156495A8 (en) Compounds and methods for modulating bruton's tyrosine kinase
ZA201908445B (en) Recombinant adenoviruses carrying transgenes
MX2021003013A (en) Recombinant poxviruses for cancer immunotherapy.
CO2021008980A2 (en) Achromosomal dynamic active systems
EP3952966A4 (en) Seal-forming structure, positioning and stabilizing structure and diffuser vent for patient interface
WO2017156370A3 (en) Technique for increasing throughput for channel bonding
EP3816201A4 (en) Polymerizable composition for optical member, and optical member
EP3723731A4 (en) Amphiphilic block copolymers, micelles, and methods for treating or preventing heart failure
EP4053174A4 (en) Method for preparing olefin-polar monomer copolymer
EP4054856A4 (en) Applying and using unique unclonable physical identifiers
WO2023230481A8 (en) Orthopoxvirus vaccines
EP4061417A4 (en) Vaccinia viruses and methods for using vaccinia viruses
MX2020009262A (en) Parapoxvirus vectors.
MX2020007393A (en) Phosphor(n)amidatacetal and phosph(on)atalcetal compounds.
WO2009026456A3 (en) Poxvirus methods and compositions
EP3942209A4 (en) Quick connect fluid connector, swivel, and combination thereof
EP3927892A4 (en) Connection assembly, levelling or lifting system, and method of levelling a slab

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23731487

Country of ref document: EP

Kind code of ref document: A1