WO2023227746A3 - Signature moléculaire de lentigo actinique associée à la gestion de vésicules - Google Patents
Signature moléculaire de lentigo actinique associée à la gestion de vésicules Download PDFInfo
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- WO2023227746A3 WO2023227746A3 PCT/EP2023/064124 EP2023064124W WO2023227746A3 WO 2023227746 A3 WO2023227746 A3 WO 2023227746A3 EP 2023064124 W EP2023064124 W EP 2023064124W WO 2023227746 A3 WO2023227746 A3 WO 2023227746A3
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- WO
- WIPO (PCT)
- Prior art keywords
- management
- skin
- vesicle
- pigmentary
- genes
- Prior art date
Links
- 206010064127 Solar lentigo Diseases 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 210000003491 skin Anatomy 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- -1 ARC Proteins 0.000 abstract 1
- 102100026292 Asialoglycoprotein receptor 1 Human genes 0.000 abstract 1
- 102100032850 Beta-1-syntrophin Human genes 0.000 abstract 1
- 102100038216 Charged multivesicular body protein 4c Human genes 0.000 abstract 1
- 101150055427 Chmp4c gene Proteins 0.000 abstract 1
- 101000785944 Homo sapiens Asialoglycoprotein receptor 1 Proteins 0.000 abstract 1
- 101000868444 Homo sapiens Beta-1-syntrophin Proteins 0.000 abstract 1
- 101000852486 Homo sapiens Inositol 1,4,5-triphosphate receptor associated 2 Proteins 0.000 abstract 1
- 101000997838 Homo sapiens Janus kinase and microtubule-interacting protein 2 Proteins 0.000 abstract 1
- 101001027628 Homo sapiens Kinesin-like protein KIF21A Proteins 0.000 abstract 1
- 101000577555 Homo sapiens Neuritin Proteins 0.000 abstract 1
- 101000582005 Homo sapiens Neuron navigator 3 Proteins 0.000 abstract 1
- 101000609959 Homo sapiens Protein piccolo Proteins 0.000 abstract 1
- 101001099887 Homo sapiens Rab-3A-interacting protein Proteins 0.000 abstract 1
- 101001130471 Homo sapiens Ras-interacting protein 1 Proteins 0.000 abstract 1
- 101001075558 Homo sapiens Rho GTPase-activating protein 29 Proteins 0.000 abstract 1
- 101000666607 Homo sapiens Rho-related BTB domain-containing protein 3 Proteins 0.000 abstract 1
- 101000835984 Homo sapiens SLIT and NTRK-like protein 6 Proteins 0.000 abstract 1
- 101000630730 Homo sapiens Small VCP/p97-interacting protein Proteins 0.000 abstract 1
- 101000659053 Homo sapiens Synaptopodin-2 Proteins 0.000 abstract 1
- 101000851357 Homo sapiens Troponin T, slow skeletal muscle Proteins 0.000 abstract 1
- 102100036343 Inositol 1,4,5-triphosphate receptor associated 2 Human genes 0.000 abstract 1
- 102100037688 Kinesin-like protein KIF21A Human genes 0.000 abstract 1
- 102100028749 Neuritin Human genes 0.000 abstract 1
- 102100030464 Neuron navigator 3 Human genes 0.000 abstract 1
- 102100039154 Protein piccolo Human genes 0.000 abstract 1
- 102100038475 Rab-3A-interacting protein Human genes 0.000 abstract 1
- 102100031429 Ras-interacting protein 1 Human genes 0.000 abstract 1
- 102100020899 Rho GTPase-activating protein 29 Human genes 0.000 abstract 1
- 102100038342 Rho-related BTB domain-containing protein 3 Human genes 0.000 abstract 1
- 102100025504 SLIT and NTRK-like protein 6 Human genes 0.000 abstract 1
- 102100023152 Scinderin Human genes 0.000 abstract 1
- 102100026336 Small VCP/p97-interacting protein Human genes 0.000 abstract 1
- 101710190410 Staphylococcal complement inhibitor Proteins 0.000 abstract 1
- 102100035603 Synaptopodin-2 Human genes 0.000 abstract 1
- 102100036860 Troponin T, slow skeletal muscle Human genes 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 210000002780 melanosome Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/148—Screening for cosmetic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La présente invention concerne une méthode de caractérisation d'une tache pigmentaire de la peau apparente ou suspecté chez un être humain, comprenant la mesure des niveaux d'expression puis la comparaison des niveaux d'expression mesurés, dans des échantillons de peau provenant de ladite tache et provenant de la peau non lésée adjacente, d'au moins un gène impliqué dans la gestion de vésicules, de préférence des mélanosomes, choisi dans la liste constituée des gènes JAKMIP2, ARC, KIF21A, SLITRK6, NRN1, SCIN, SYNPO2, TNNT1, SNTB1, ARHGAP29, RAB3IP, RHOBTB3, RASIP1, ASGR1, CHMP4C, SVIP, LRMP, NAV3 et PCLO. L'invention concerne également des méthodes d'évaluation de l'efficacité d'un traitement des taches pigmentaires, des méthodes cosmétiques de traitement des taches pigmentaires, ainsi que divers modulateurs desdits gènes et leur utilisation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2205044A FR3135992A1 (fr) | 2022-05-25 | 2022-05-25 | Signature moléculaire du lentigo actinique associée à la gestion des vésicules |
FRFR2205044 | 2022-05-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2023227746A2 WO2023227746A2 (fr) | 2023-11-30 |
WO2023227746A3 true WO2023227746A3 (fr) | 2024-01-04 |
Family
ID=85222013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2023/064124 WO2023227746A2 (fr) | 2022-05-25 | 2023-05-25 | Signature moléculaire de lentigo actinique associée à la gestion de vésicules |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR3135992A1 (fr) |
WO (1) | WO2023227746A2 (fr) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009140550A2 (fr) * | 2008-05-14 | 2009-11-19 | Dermtech International | Diagnostic de mélanome et de lentigo solaire par analyse d'acides nucléiques |
WO2012013776A2 (fr) * | 2010-07-30 | 2012-02-02 | Nestec S.A. | Utilisation de grains de café vert pour réguler des troubles de la pigmentation de la peau |
US20120244131A1 (en) * | 2011-02-04 | 2012-09-27 | Cellectis Sa | Method for modulating the efficiency of double-strand break-induced mutagenesis |
FR2974370A1 (fr) * | 2011-04-22 | 2012-10-26 | Oreal | Signature moleculaire des taches pigmentaires cutanees, associee a la voie de signalisation tgf-beta - smad |
US20150166646A1 (en) * | 2012-06-15 | 2015-06-18 | The Wistar Institute Of Anatomy And Biology | Methods and Compositions for Treating or Diagnosing Melanoma |
US20200348313A1 (en) * | 2019-03-19 | 2020-11-05 | Incyte Corporation | Biomarkers for vitiligo |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR332E (fr) | 1902-01-04 | 1902-12-11 | Ostwald Wilhelm | Procédé de fabrication de l'acide nitrique |
FR2974372B1 (fr) | 2011-04-22 | 2016-09-02 | Oreal | Signature moleculaire des taches pigmentaires cutanees, associee au remodelage de la matrice extracellulaire |
FR2974371B1 (fr) | 2011-04-22 | 2016-10-28 | Oreal | Signature moleculaire des taches pigmentaires cutanees, associee a la famille des proteoglycanes et glycoproteines extracellulaires |
FR2974373B1 (fr) | 2011-04-22 | 2016-09-02 | Oreal | Signature moleculaire des taches pigmentaires cutanees, associee a la matrice extracellulaire |
-
2022
- 2022-05-25 FR FR2205044A patent/FR3135992A1/fr active Pending
-
2023
- 2023-05-25 WO PCT/EP2023/064124 patent/WO2023227746A2/fr unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009140550A2 (fr) * | 2008-05-14 | 2009-11-19 | Dermtech International | Diagnostic de mélanome et de lentigo solaire par analyse d'acides nucléiques |
WO2012013776A2 (fr) * | 2010-07-30 | 2012-02-02 | Nestec S.A. | Utilisation de grains de café vert pour réguler des troubles de la pigmentation de la peau |
US20120244131A1 (en) * | 2011-02-04 | 2012-09-27 | Cellectis Sa | Method for modulating the efficiency of double-strand break-induced mutagenesis |
FR2974370A1 (fr) * | 2011-04-22 | 2012-10-26 | Oreal | Signature moleculaire des taches pigmentaires cutanees, associee a la voie de signalisation tgf-beta - smad |
US20150166646A1 (en) * | 2012-06-15 | 2015-06-18 | The Wistar Institute Of Anatomy And Biology | Methods and Compositions for Treating or Diagnosing Melanoma |
US20200348313A1 (en) * | 2019-03-19 | 2020-11-05 | Incyte Corporation | Biomarkers for vitiligo |
Non-Patent Citations (9)
Title |
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ESPINOSA ERIC J. ET AL: "RhoBTB3: A Rho GTPase-Family ATPase Required for Endosome to Golgi Transport", CELL, vol. 137, no. 5, 29 May 2010 (2010-05-29), Amsterdam NL, pages 938 - 948, XP093105994, ISSN: 0092-8674, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801561/pdf/nihms108740.pdf> DOI: 10.1016/j.cell.2009.03.043 * |
GUO WEIHONG ET AL: "Promotion of Cell Proliferation through Inhibition of Cell Autophagy Signalling Pathway by Rab3IP is Restrained by MicroRNA-532-3p in Gastric Cancer", JOURNAL OF CANCER, vol. 9, no. 23, 1 January 2018 (2018-01-01), AU, pages 4363 - 4373, XP093105955, ISSN: 1837-9664, Retrieved from the Internet <URL:https://www.jcancer.org/v09p4363.pdf> DOI: 10.7150/jca.27533 * |
HUAN LIU ET AL: "Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate", BIRTH DEFECTS RESEARCH, JOHN WILEY & SONS, INC, HOBOKEN, USA, vol. 109, no. 1, 23 January 2017 (2017-01-23), pages 27 - 37, XP072279705, ISSN: 2472-1727, DOI: 10.1002/BDRA.23596 * |
ORTONNE J-P: "Management of actinic lentigo and melasma: ECLAIR international study. Profile of patients, conditions and efficiency of Iklen(R) Rucinol treatment", NOUVELLES DERMATOLOGIQUES, STRASBOURG, FR, vol. 26, no. 8, 1 January 2007 (2007-01-01), pages 499 - 504, XP009093664, ISSN: 0752-5370 * |
ROSSI A.B.: "Clinical and instrumental efficacy of a dermocosmetic with Uniwhite peptide, niacinamide, vitC and hyaluronic acid on reducing actinic lentigo and improving photoaging", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 74, no. 5, 31 May 2016 (2016-05-31), XP029517864, ISSN: 0190-9622, DOI: 10.1016/J.JAAD.2016.02.911 * |
WARRICK E ET AL: "Morphological and molecular characterization of actinic lentigos reveals alterations of the dermal extracellular matrix", BRITISH JOURNAL OF DERMATOLOGY, JOHN WILEY, HOBOKEN, USA, vol. 177, no. 6, 16 November 2017 (2017-11-16), pages 1619 - 1632, XP071054051, ISSN: 0007-0963, DOI: 10.1111/BJD.15697 * |
WARRICK E ET AL: "Supplementary information 1 for "Morphological and molecular characterization of actinic lentigos reveals alterations of the dermal extracellular matrix"", BRITISH JOURNAL OF DERMATOLOGY, 1 June 2017 (2017-06-01), pages 1 - 12, XP093037680, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fbjd.15697&file=bjd15697-sup-0001-Supinfo1.pdf> [retrieved on 20230405] * |
WARRICK E ET AL: "Supplementary Material 2 for "Morphological and molecular characterization of actinic lentigos reveals alterations of the dermal extracellular matrix"", BRITISH JOURNAL OF DERMATOLOGY, 1 June 2017 (2017-06-01), pages 1 - 3, XP093037681, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fbjd.15697&file=bjd15697-sup-0002-Supinfo2.pdf> [retrieved on 20230405] * |
WU ZHIQIANG ET AL: "Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRP[alpha]-CD47 axis", CELL RESEARCH, SPRINGER SINGAPORE, SINGAPORE, vol. 29, no. 6, 14 May 2019 (2019-05-14), pages 502 - 505, XP036854726, ISSN: 1001-0602, [retrieved on 20190514], DOI: 10.1038/S41422-019-0177-0 * |
Also Published As
Publication number | Publication date |
---|---|
WO2023227746A2 (fr) | 2023-11-30 |
FR3135992A1 (fr) | 2023-12-01 |
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