WO2023215407A3 - Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases - Google Patents

Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases Download PDF

Info

Publication number
WO2023215407A3
WO2023215407A3 PCT/US2023/020878 US2023020878W WO2023215407A3 WO 2023215407 A3 WO2023215407 A3 WO 2023215407A3 US 2023020878 W US2023020878 W US 2023020878W WO 2023215407 A3 WO2023215407 A3 WO 2023215407A3
Authority
WO
WIPO (PCT)
Prior art keywords
dipa
phosphinoyl
isopropyl
treatment
eye diseases
Prior art date
Application number
PCT/US2023/020878
Other languages
French (fr)
Other versions
WO2023215407A2 (en
Inventor
Edward Wei
Original Assignee
Iview Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/803,311 external-priority patent/US20220265687A1/en
Application filed by Iview Therapeutics, Inc. filed Critical Iview Therapeutics, Inc.
Publication of WO2023215407A2 publication Critical patent/WO2023215407A2/en
Publication of WO2023215407A3 publication Critical patent/WO2023215407A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention pertains to a method for treating an eye disease in a subject in need of such a treatment. The method includes administering to the subject a composition comprising a therapeutically effective amount of a 1-di-isopropyl-phosphinoyl-alkane (DIPA) compound. The DIPA compound is a compound selected from DIPA-1-7, DIPA-1-8, and DIPA-1-9. The eye diseases include blepharitis and conjunctivitis.
PCT/US2023/020878 2022-05-03 2023-05-26 Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases WO2023215407A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17/803,311 2022-05-03
US17/803,311 US20220265687A1 (en) 2018-11-30 2022-05-03 Di-Isopropyl-Phosphinoyl -Alkanes as topical agents for the treatment of sensory discomfort

Publications (2)

Publication Number Publication Date
WO2023215407A2 WO2023215407A2 (en) 2023-11-09
WO2023215407A3 true WO2023215407A3 (en) 2024-02-08

Family

ID=88647000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2023/020878 WO2023215407A2 (en) 2022-05-03 2023-05-26 Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases

Country Status (1)

Country Link
WO (1) WO2023215407A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180126908A (en) * 2017-05-19 2018-11-28 에드워드 택 웨이 Method for Increasing Light Reflectance from the Eyes
US20190105335A1 (en) * 2014-12-29 2019-04-11 Edward T. Wei Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of sensory discomfort
US20210059998A1 (en) * 2014-06-24 2021-03-04 Sydnexis, Inc. Ophthalmic composition
WO2022150730A1 (en) * 2021-01-11 2022-07-14 Iview Therapeutics, Inc. Treatment of neuropathic sensitization disorders
US20220265687A1 (en) * 2018-11-30 2022-08-25 Edward T. Wei Di-Isopropyl-Phosphinoyl -Alkanes as topical agents for the treatment of sensory discomfort

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210059998A1 (en) * 2014-06-24 2021-03-04 Sydnexis, Inc. Ophthalmic composition
US20190105335A1 (en) * 2014-12-29 2019-04-11 Edward T. Wei Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of sensory discomfort
KR20180126908A (en) * 2017-05-19 2018-11-28 에드워드 택 웨이 Method for Increasing Light Reflectance from the Eyes
US20220265687A1 (en) * 2018-11-30 2022-08-25 Edward T. Wei Di-Isopropyl-Phosphinoyl -Alkanes as topical agents for the treatment of sensory discomfort
WO2022150730A1 (en) * 2021-01-11 2022-07-14 Iview Therapeutics, Inc. Treatment of neuropathic sensitization disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "1-diisopropylphosphorylheptane", XP093137393, retrieved from PUBCHEM *

Also Published As

Publication number Publication date
WO2023215407A2 (en) 2023-11-09

Similar Documents

Publication Publication Date Title
CO5670356A2 (en) DOSAGE PROGRAM FOR A NEW ANTI-BANKING AGENT
DE60225556D1 (en) DPP-IV INHIBITING PURINE DERIVATIVE FOR THE TREATMENT OF DIABETES
NO20054958L (en) Substituted amino carboxylic acids
NO20055129L (en) Phenyl-substituted carboxylic acids
BR0211119A (en) Compound, method of treating a patient who has, or preventing a patient from catching, a disease or condition, use of a compound, and method for making a compound
ES2191069T3 (en) DIARIL-2- (5H) -FURANONAS AS COX-2 INHIBITORS.
EA200500234A1 (en) COMBINED THERAPY OF HYPERPROLIFERATIVE DISEASES
MX2023003627A (en) 1,2,3,4-tetrahydroquinoline derivatives as inhibitors of the yap/taz-tead activation for treating cancer.
TW200639159A (en) Treatment of pain
MX2022015531A (en) Pyridine-pyrimidine derivative, preparation method therefor and pharmaceutical use thereof.
BRPI0506493A (en) therapeutic combinations
TN2009000004A1 (en) Compositions and methods for the treatment of mucormycosis and other fungal diseases
BR112022024483A2 (en) METHODS TO TREAT MULTIPLE MYELOMA
MX2023007027A (en) Cannabinoid derivative as a pharmaceutically active compound and method of preparation thereof.
EP4397375A3 (en) Isoxazoline parasiticide formulations and methods for treating blepharitis
MX2023006504A (en) Hydroxamate compound, preparation method therefor and application thereof.
MX2022003845A (en) Medicinal cognitive treatments.
WO2020128614A8 (en) Method for treating interstital lung disease
WO2022192594A3 (en) Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease
WO2022079290A3 (en) Heterocyclic cullin ring ubiquitin ligase compounds and uses thereof
WO2023215407A3 (en) Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of eye diseases
MX2021016055A (en) Isoxazoline parasiticide formulations and methods for treating blepharitis.
EA202190798A1 (en) ROTAMERIC ISOMERS OF 4-ALKYL-5-HETEROARYL-3H-1,2-DITHIOL-3-THIONES
MX2021002936A (en) Use of low volume plasma exchange for treating the early and middle stages of alzheimer's disease.
HRP20041150A2 (en) Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23799995

Country of ref document: EP

Kind code of ref document: A2