WO2023209665A1 - Distributeur de médicament servant à disperser des médicaments en poudre sèche - Google Patents

Distributeur de médicament servant à disperser des médicaments en poudre sèche Download PDF

Info

Publication number
WO2023209665A1
WO2023209665A1 PCT/IB2023/054444 IB2023054444W WO2023209665A1 WO 2023209665 A1 WO2023209665 A1 WO 2023209665A1 IB 2023054444 W IB2023054444 W IB 2023054444W WO 2023209665 A1 WO2023209665 A1 WO 2023209665A1
Authority
WO
WIPO (PCT)
Prior art keywords
inlet
conduit
chamber
bleed
outlet
Prior art date
Application number
PCT/IB2023/054444
Other languages
English (en)
Inventor
Adam BARRETT
Adam STUART
Original Assignee
Merxin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/732,853 external-priority patent/US20230347079A1/en
Priority claimed from GB2206312.7A external-priority patent/GB2618145A/en
Application filed by Merxin Ltd filed Critical Merxin Ltd
Publication of WO2023209665A1 publication Critical patent/WO2023209665A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

  • This invention relates to medicament dispensers for dispensing dry powder medicaments. More particularly, this invention relates to a medicament dispenser having a manifold particularly configured for delivery of medicament powder from the medicament dispenser device.
  • inhalation devices in the administration of medicaments, for example in bronchodilation therapy is well known.
  • Such devices generally comprise a body or housing within which a supply of medicament carrier is located.
  • Known inhalation devices include those in which the supply of medicament is a blister pack containing a number of blister pockets for containment of medicament in dry powder form.
  • Such devices typically contain a mechanism for accessing a medicament dose by opening one or more blister pockets.
  • the mechanism may, for example, comprise either a piercing means or a peeling means to peel a lid sheet away from a base sheet of the blister pack.
  • the powdered medicament is then liberated from the opened blister pocket(s) for inhaled delivery to the patient.
  • Inhalation devices of the type described above typically comprise an element, referred to as a manifold, for guiding airflow towards the one or more opened blister pocket(s) for liberating the powdered medicament contained therein, and subsequently guiding the liberated powder to a mouthpiece for inhalation by a patient.
  • a manifold for guiding airflow towards the one or more opened blister pocket(s) for liberating the powdered medicament contained therein, and subsequently guiding the liberated powder to a mouthpiece for inhalation by a patient.
  • the form of the manifold is known to affect the particle size characteristics of the liberated medicament powder. Such characteristics are known to be pharmaceutically important.
  • the fine particle fraction can be influenced by the form of the manifold.
  • the "fine particle fraction" or FP fraction generally refers to the percentage of particles within a given dose of aerosolised medicament that is of "respirable" size.
  • a first aspect of the invention provides a manifold for delivery of medicament powder from a dispenser device.
  • the manifold comprises a first chamber comprising a first chamber inlet and a first chamber outlet, the first chamber arranged to direct a first flow of air from the first chamber inlet to the first chamber outlet.
  • the manifold also comprises a conduit having a conduit inlet and a conduit outlet, wherein the first chamber outlet and the conduit inlet are arranged such that when a supply of medicament powder is positioned proximal thereto the first flow of air is directed from the first chamber outlet to the conduit inlet via the supply of medicament powder to entrain the medicament powder and provide a flow of air entrained with medicament powder through the conduit from the conduit inlet to the conduit outlet.
  • the manifold further comprises a bleed inlet in a wall of the conduit outside of the first chamber arranged to direct a second flow of air into the conduit to disruptively impact the flow of air entrained with medicament powder through the conduit.
  • such an arrangement may advantageously provide for a finer level of control over the device resistance, and FP fraction performance by allowing for the first flow of air into the supply of medicament powder to be separated from second flow of air directed into the conduit through the bleed hole.
  • such an arrangement has been found to advantageously increase the FP fraction of the aerosolised medicament powder and reduce the impact of variations in flow rate on the FP fraction.
  • it may be possible to modify the geometry of each of the first chamber and the bleed inlet independently without affecting the performance of the other.
  • the first chamber outlet and conduit inlet may be arranged such that when a supply of medicament powder is positioned adjacent thereto the first flow of air is directed from the first chamber outlet to the conduit inlet via the supply of medicament powder to entrain the medicament powder and provide a flow of air entrained with medicament powder through the conduit from the conduit inlet to the conduit outlet.
  • the first chamber inlet may be arranged to draw air external to (i.e. outside of) a dispenser device comprising the manifold into the first chamber.
  • the first chamber inlet may be in fluid connection with a first device inlet of a dispenser device comprising the manifold, the first device inlet being arranged to draw air external to the device into the device.
  • the bleed inlet may be arranged to draw air external to a dispenser device comprising the manifold into the conduit.
  • the bleed inlet may be in fluid connection with a second device inlet of a dispenser device comprising the manifold, the second device inlet being arranged to draw air external to the device into the device.
  • the manifold may comprise a second chamber.
  • the second chamber may comprise a second chamber inlet arranged to direct a second flow of air from the second chamber inlet to the bleed inlet.
  • the second chamber inlet may be arranged to draw air external to (i.e. outside of) a dispenser device comprising the manifold into the second chamber.
  • the second chamber inlet may be in fluid connection with a second device inlet of a dispenser device comprising the manifold, the second device inlet being arranged to draw air external to the device into the device.
  • the first and second chambers may be located on substantially opposite sides of the conduit.
  • the first and second chambers may be located substantially on a same side of the conduit.
  • the first and second chambers may be arranged substantially side-by-side.
  • the bleed inlet may be located on a first side of the conduit and the first chamber may be located at a second side of the conduit generally orthogonal to the first side of the conduit.
  • the bleed inlet may be located on a first side of the conduit and the first chamber may be located at a second side of the conduit generally at a right angle (i.e. at about 90°) to the first side of the conduit.
  • the direction of the bleed inlet into the conduit may be generally orthogonal to the direction of the first chamber inlet into the first chamber.
  • the direction of the bleed inlet into the conduit may be generally at a right angle (i.e. at about 90°) to the direction of the first chamber inlet into the first chamber.
  • the direction of the bleed inlet into the conduit may be generally orthogonal to the direction of the second chamber inlet into the second chamber.
  • the direction of the bleed inlet into the conduit may be generally at a right angle (i.e. at about 90°) to the direction of the second chamber inlet into the second chamber.
  • the bleed inlet may be located on a first side of the conduit and the first chamber may be located at a second side of the conduit substantially opposite to the first side.
  • the direction of the bleed inlet into the conduit may be generally in line with the direction of the first chamber inlet into the first chamber.
  • the direction of the bleed inlet into the conduit may be generally in the same plane as the direction of the first chamber inlet into the first chamber.
  • the direction of the bleed inlet into the conduit may be generally in line with the direction of the second chamber inlet into the second chamber.
  • the direction of the bleed inlet into the conduit may be generally in the same plane as the direction of the second chamber inlet into the second chamber.
  • the bleed inlet and first chamber may be located substantially on the same side of the conduit.
  • the direction of the bleed inlet into the conduit may be generally parallel to the direction of the first chamber inlet into the first chamber.
  • the manifold may comprise a pair of bleed inlets.
  • the pair of bleed inlets may be located substantially on the same side of the conduit.
  • the pair of bleed inlets may be arranged substantially side-by-side.
  • the first chamber outlet and/or the conduit inlet may comprise a baffle.
  • the baffle may comprise a grille and/or cross-piece spanning the outlet/in let.
  • the presence of a baffle may advantageously be used to control air flow through the first chamber outlet and/or the conduit inlet.
  • the presence of a baffle may serve to prevent large particles of dry powder (i.e. having a particle size falling outside the upper limit of a defined size range) from entering the conduit inlet.
  • the conduit may have an elongate length between the conduit inlet and the conduit outlet.
  • the bleed inlet may be located partway along the length of the conduit between the conduit inlet and the conduit outlet.
  • the bleed inlet may be located at or between one third and two thirds of the length of the conduit.
  • the conduit may be located about halfway along the length of the conduit, i.e. at or towards the middle of the length of the conduit.
  • the bleed inlet may comprise a circular or elliptical opening in the wall of the conduit. In some embodiments, the bleed inlet may comprise an oblong or oval opening in the wall of the conduit. Suitably, the bleed inlet may generally elongate having curved first and second ends.
  • the bleed inlet may define an opening in the wall of the conduit having a width across the opening, and a depth through the wall of the conduit.
  • the bleed inlet may have a width across the opening greater than the depth of the bleed inlet through the wall of the conduit.
  • the bleed inlet may have a width across the widest point of the opening greater than the depth of the bleed inlet through the wall of the conduit.
  • the bleed inlet may have a diameter greater than the depth of the bleed inlet through the wall of the conduit.
  • the manifold may be formed from a single moulding.
  • the single moulding may be injection moulded.
  • the manifold may be formed by the abutment of two or more moulded parts.
  • one or more of the moulded parts may be injection moulded.
  • a second aspect of the invention provides a dispenser device comprising: a manifold according to the first aspect of the invention; and a medicament chamber in fluid connection with the first chamber outlet and the conduit inlet, wherein the medicament chamber comprises a supply of medicament powder.
  • the dispenser device may comprise first and second device inlets in fluid connection with the first chamber inlet and the bleed inlet respectively.
  • the dispenser device may comprise first and second device inlets in fluid connection with the first and second chamber second inlets respectively.
  • the first device inlet may be located on first side of the device and the second device inlet may be located on a second side of the device substantially opposite to the first side of the device.
  • the first and second device inlets may be located substantially on the same side of the device.
  • the first and second device inlets may be arranged substantially side-by-side.
  • the dispenser device may comprise a device inlet in fluid connection with the first chamber and the bleed inlet.
  • a wall of the first chamber of the manifold may abut the device inlet to divide external air entering the dispenser device through the device inlet into first and second flows of air inside the device.
  • the supply of medicament powder may comprise a blister pack.
  • the supply of medicament powder may comprise an open blister pocket of a blister pack.
  • the supply of medicament powder may comprise a plurality of blister packs.
  • the supply of medicament powder may comprise a plurality of open blister pockets of one or more blister packs.
  • the supply of medicament powder may comprise a capsule, for example such as a gelatin capsule.
  • the supply of medicament powder may comprise a pierced capsule.
  • the supply of medicament powder may comprise a plurality of capsules.
  • the supply of medicament powder may comprise a plurality of pierced capsules.
  • the dispenser device may comprise a mouthpiece in fluid connection with the conduit outlet.
  • Figure 1 A shows a perspective view of a first embodiment of a manifold that forms part of a medicament dispenser
  • Figure 1 B shows a cross-sectional view of the manifold of Figure 1 A
  • Figure 1 C shows a cross-sectional view of the manifold of Figure 1 A inside a dispenser device
  • Figure 2A shows perspective view of a manifold in accordance with a second embodiment of the invention
  • Figure 2B shows a side view of the manifold of Figure 2A
  • Figure 2C shows a cross-sectional view of the manifold of Figure 2A
  • Figure 3A shows a perspective view of a manifold in accordance with a third embodiment of the invention.
  • Figure 3B shows a side view of the manifold of Figure 3A
  • Figure 3C shows a cross-sectional view of the manifold of Figure 3A inside a dispenser device
  • Figure 4A shows a perspective view of a manifold in accordance with a fourth embodiment of the invention.
  • Figure 4B shows a side view of the manifold of Figure 4A
  • Figure 4C shows a cross-sectional view of the manifold of Figure 4A inside a dispenser device
  • Figure 5A shows a perspective view of a manifold in accordance with a fifth embodiment of the invention
  • Figure 5B shows a side view of the manifold of Figure 5A.
  • Figure 5C shows a cross-sectional view of the manifold of Figure 5A inside a dispenser device.
  • Embodiments of medicament dispensers for dispensing dry powder medicaments will now be described with reference to the figures.
  • a first embodiment of dispenser device 10 is shown in figure 1 C.
  • the dispenser device 10 has a main body 150 that has first and second inlet grates 12, 18 and a mouthpiece 19.
  • the dispenser device 10 comprises a manifold 100, located inside the main body, that is described in detail below.
  • the first inlet grate 12 is in fluid connection with a first chamber inlet 102A that forms part of the manifold 100.
  • the second inlet grate 18 is in fluid connection with the second chamber inlet 108A that forms part of the manifold 100.
  • the mouthpiece 19 is in fluid connection with the conduit outlet 104B that forms part of the manifold 100.
  • FIG. 1 A A first embodiment of manifold 100 that forms part of the dispenser device 10 is shown in figures 1 A and 1 B.
  • the manifold 100 comprises a first chamber 102 comprising a first chamber inlet 102A and a first chamber outlet 102B.
  • the manifold 100 also has a conduit 104 having a conduit inlet 104A and a conduit outlet 104B.
  • the conduit 104 has an elongate length between the conduit inlet 104A and the conduit outlet 104B.
  • a pair of bleed inlets 106 are arranged side-by-side in a wall of the conduit 104 outside of the first chamber 102.
  • the pair of bleed inlets 106 are located partway (about halfway) along the length of the conduit 104, between the conduit inlet and the conduit outlet.
  • Each of the bleed inlets 106 defines an oblong shaped opening in the wall of the conduit 104.
  • the bleed inlet has a width across the opening greater than the depth of the bleed inlet through the wall of the conduit.
  • the manifold 100 further comprises a second chamber 108 having a second chamber inlet 108A.
  • the second chamber 108 is in fluid connection with the pair of bleed inlets 106.
  • the first chamber 102 and second chamber 108 are located on opposite sides of the conduit 104.
  • the direction of each of the bleed inlets 106 into the conduit 104 is generally orthogonal to the direction of the first chamber inlet 102A into the first chamber 102 and to the direction of the second chamber inlet 108A into the second chamber 108.
  • the first chamber 102 is arranged to direct a first flow 110 of air from the first chamber inlet 102A to the first chamber outlet 102B, where it passes through a supply of medicament powder (not shown) positioned next to both the first chamber outlet 102B and conduit inlet 104A.
  • a supply of medicament powder (not shown) positioned next to both the first chamber outlet 102B and conduit inlet 104A.
  • the first flow 110 of air entrained with medicament powder then flows into the conduit inlet 104A and along the conduit 104 to the conduit outlet 104B, where it exits the manifold 100.
  • the second chamber 108 is arranged to direct a second flow 112 of air from the second chamber inlet 108A to the bleed inlets 106.
  • the bleed inlets 106 are configured to direct the second flow 112 of air into the conduit 104 to disruptively impact the first flow 110 of air entrained with medicament powder as it flows through the conduit 104. This advantageously increases the FP fraction of the medicament powder entrained in the first flow 110 of air as it passes through the conduit 104.
  • manifold 100 has been described above for use with the dispenser device 10.
  • Other forms of manifold such as those described below could also be used with the dispenser device 10.
  • the first chamber 102 is arranged so that air external to the device is drawn into the first chamber 102 of the manifold through the first inlet grate 12 on the main body of the dispenser device, and the first chamber inlet 102A on the manifold.
  • the path of this air into and through the device is shown in figure 1 B, with the external first flow of air entering the device shown by arrow 110.
  • the first flow 110 of air passes through the supply of medicament powder positioned next to both the first chamber outlet 102B, and then flows into the conduit inlet 104A, which also has a supply of medicament powder.
  • the flow of air becomes entrained with the medicament powder as it passes the outlet 102B and the inlet 104A.
  • the flow of air 110 with the entrained medicament powder then passes along the conduit 104 to the conduit outlet 104B, where it exits the manifold 100, and substantially simultaneously exits the device 10 through the mouthpiece 19.
  • the bleed inlets 106 are located and configured to direct the second flow 112 of air into the conduit 104 so that this air flow disruptively impacts the first flow 110 of air - the air entering the conduit 104 via the conduit inlet 104A that is entrained with medicament powder - as it flows through the conduit 104.
  • This disruptive impact and mixing advantageously increases the FP fraction of the medicament powder entrained in the first flow 110 of air as it passes through the conduit 104.
  • first inlet grate 12 and the first chamber inlet 102A are located on one, or a first, side of main body 150, and that the separate second inlet grate 18 and second chamber inlet 108A are located on a second side of the main body 150 that is separate to, or away from, the first side.
  • the second inlet grate 18 and second chamber inlet 108A are on substantially the opposite side of the main body 150 to the first inlet grate 12 and the first chamber inlet 102A - that is, separated by substantially 180 degrees or a half-circle or half-turn.
  • the main body could be arranged so that the first and second sides are separated by for example a quarter-turn or similar (orthogonal to one another).
  • first and second sides are separated by for example a quarter-turn or similar (orthogonal to one another).
  • grate in this specification is intended to cover a single simple aperture, or an aperture or apertures that comprise a framework of parallel or crossed bars, or a series of smaller apertures grouped together to produce a similar effect to a single larger aperture.
  • a second embodiment of manifold 200 is shown in figures 2A and 2B.
  • the manifold 200 comprises a first chamber 202 comprising a first chamber inlet 202A and a first chamber outlet 202B.
  • the manifold 200 also has a conduit 204 having a conduit inlet 204A and a conduit outlet 204B.
  • the conduit 204 has an elongate length between the conduit inlet 204A and the conduit outlet 204B.
  • a pair of bleed inlets 206 are arranged side-by-side in a wall of the conduit 204 outside of the first chamber 202. In this example, the pair of bleed inlets 206 are located partway (about halfway) along the length of the conduit 204, between the conduit inlet and the conduit outlet.
  • Each of the bleed inlets 206 defines an oblong shaped opening in the wall of the conduit 204. In this embodiment, the bleed inlet has a width across the opening greater than the depth of the bleed inlet through the wall of the conduit.
  • the manifold 200 further comprises a second chamber 208 having a second chamber inlet 208A.
  • the second chamber 208 is in fluid connection with the pair of bleed inlets 206.
  • the first chamber 202 and second chamber 208 are located on opposite sides of the conduit 204.
  • the direction of each the bleed inlets 206 into the conduit 204 is generally in line with the direction of the first chamber inlet 202A into the first chamber 202 and with the direction of the second chamber inlet 208A into the second chamber 208.
  • the bleed inlets 206 are located on a first side of the conduit 204 and the first chamber 202 is located at a second side of the conduit 204 opposite to the first side.
  • the direction of the bleed inlet 206 into the conduit 204 is in line with the direction of the first chamber inlet 202A into the first chamber 202, as shown on figure 2C.
  • the first chamber 202 is arranged to direct a first flow of air (not shown) from the first chamber inlet 202A to the first chamber outlet 202B, where it passes through a supply of medicament powder (not shown) positioned next to both the first chamber outlet 202B and conduit inlet 204A.
  • a supply of medicament powder not shown
  • the first flow of air entrained with medicament powder then flows into the conduit inlet 204A and along the conduit 204 to the conduit outlet 204B, where it exits the manifold 200.
  • the second chamber 208 is arranged to direct a second flow of air (not shown) from the second chamber inlet 208A to the bleed inlets 206.
  • the bleed inlets 206 are configured to direct the second flow of air into the conduit 204 to disruptively impact the first flow of air entrained with medicament powder as it flows through the conduit 204. This advantageously increases the FP fraction of the medicament powder entrained in the first flow of air as it passes through the conduit 204.
  • first and second chambers 202, 208 are on opposite sides of the conduit 204, and that the openings that will receive air are substantially in line with one another and open opposite to one another.
  • a second embodiment of dispenser device 30 is shown in figure 3C.
  • the dispenser device 30 comprises a manifold 300 that is described in detail below.
  • Figure 3C provides a cross-sectional view of the manifold 300 inside a dispenser device 30.
  • the main body 350 of the dispenser device 30 has an inlet grate 32 and a mouthpiece 39.
  • the inlet grate 32 is in fluid connection with both the first and second chamber inlets 302A, 308A of the manifold 300.
  • the dividing wall 320 of the manifold abuts the inlet grate 32.
  • the mouthpiece 39 is in fluid connection with the conduit outlet 304B.
  • a third embodiment of manifold is shown in figures 3A and 3B.
  • the manifold 300 comprises a first chamber 302 comprising a first chamber inlet 302A and a first chamber outlet 302B.
  • the manifold 300 also has a conduit 304 having a conduit inlet 304A and a conduit outlet 304B.
  • the conduit 304 has an elongate length between the conduit inlet 304A and the conduit outlet 304B.
  • a pair of bleed inlets 306 are arranged side-by-side in a wall of the conduit 304 outside of the first chamber 302. In this example, the pair of bleed inlets 306 are located partway (about halfway) along the length of the conduit 304, between the conduit inlet and the conduit outlet.
  • Each of the bleed inlets 306 defines an oblong shaped opening in the wall of the conduit 304.
  • the bleed inlet has a width across the opening greater than the depth of the bleed inlet through the wall of the conduit.
  • the manifold 300 further comprises a second chamber 308 having a second chamber inlet 308A.
  • the second chamber 308 is in fluid connection with the pair of bleed inlets 306.
  • the first chamber 302 and second chamber 308 are located side-by-side (i.e. adjacent to one another) on the same side of the conduit 304.
  • the first and second chambers 302, 308 are separated from each other by a dividing wall 320.
  • the direction of each of the bleed inlets 306 into the conduit 304 is generally orthogonal to the direction of the first chamber inlet 302A into the first chamber 302 and to the direction of the second chamber inlet 308A into the second chamber 308.
  • the first chamber 302 is arranged to direct a first flow of air (not shown) from the first chamber inlet 302A to the first chamber outlet 302B, where it passes through a supply of medicament powder (not shown) positioned next to both the first chamber outlet 302B and conduit inlet 304A.
  • a supply of medicament powder not shown
  • the first flow of air entrained with medicament powder then flows into the conduit inlet 304A and along the conduit 304 to the conduit outlet 304B, where it exits the manifold 300.
  • the second chamber 308 is arranged to direct a second flow of air (not shown) from the second chamber inlet 308A to the bleed inlets 306.
  • the bleed inlets 306 are configured to direct the second flow of air into the conduit 304 to disruptively impact the first flow of air entrained with medicament powder as it flows through the conduit 304. This advantageously increases the FP fraction of the medicament powder entrained in the first flow of air as it passes through the conduit 304.
  • the first chamber 302 of the manifold is arranged to draw air external to the device 30 into the first chamber 302 through the inlet grate 32 and first chamber inlet 302A.
  • the second chamber 308 is arranged to draw air external to the device 30 into the second chamber 308 through the inlet grate 32 and second chamber inlet 308A.
  • the dividing wall 320 acts to divide the air drawn in through the inlet grate 32 into separate first and second air flows (not shown) in the first and second chambers 302, 308 respectively.
  • the first flow of air entrained with medicament powder exits the device 30 through the mouthpiece 39.
  • a third embodiment of dispenser device 30 is shown in figure 4C.
  • the main body 450 of the dispenser device 30 comprises a manifold 400 that is described in detail below.
  • Figure 4C provides a cross-sectional view of the manifold 400 inside a dispenser device 40.
  • the dispenser device 40 has first and second inlet grates 42, 48 and a mouthpiece 49.
  • the first inlet grate 42 is in fluid connection with a first chamber inlet 402A on the manifold 400.
  • the second inlet grate 48 is in fluid connection with a second chamber inlet 408A on the manifold 400.
  • the mouthpiece 49 is in fluid connection with the conduit outlet 404B.
  • the manifold 400 is shown in detail in figures 4A and 4B.
  • the manifold 400 comprises a first chamber 402 comprising a first chamber inlet 402A and a first chamber outlet 402B.
  • the manifold 400 also has a conduit 404 having a conduit inlet 404A and a conduit outlet 404B.
  • the conduit 404 has an elongate length between the conduit inlet 404A and the conduit outlet 404B.
  • a pair of bleed inlets 406 are arranged side-by-side in a wall of the conduit 404 outside of the first chamber 402. In this example, the pair of bleed inlets 406 are located partway (about halfway) along the length of the conduit 404, between the conduit inlet and the conduit outlet.
  • Each of the bleed inlets 406 defines an oblong shaped opening in the wall of the conduit 404. In this embodiment, the bleed inlet has a width across the opening greater than the depth of the bleed inlet through the wall of the conduit.
  • the manifold 400 further comprises a second chamber 408 having a second chamber inlet 408A.
  • the second chamber 408 is in fluid connection with the pair of bleed inlets 406.
  • the first chamber 402 and second chamber 408 are located on opposite sides of the conduit 404.
  • the direction of each of the bleed inlets 406 into the conduit 404 is orthogonal to the direction of the first chamber inlet 402A into the first chamber 402 and to the direction of the second chamber inlet 408A into the second chamber 408.
  • the first chamber 402 is arranged to direct a first flow of air (not shown) from the first chamber inlet 402A to the first chamber outlet 402B, where it passes through a supply of medicament powder (not shown) positioned next to both the first chamber outlet 402B and conduit inlet 404A.
  • a supply of medicament powder not shown
  • the first flow of air entrained with medicament powder then flows into the conduit inlet 404A and along the conduit 404 to the conduit outlet 404B, where it exits the manifold 400.
  • the second chamber 408 is arranged to direct a second flow of air (not shown) from the second chamber inlet 408A to the bleed inlets 406.
  • the bleed inlets 406 are configured to direct the second flow of air into the conduit 404 to disruptively impact the first flow of air entrained with medicament powder as it flows through the conduit 404. This advantageously increases the FP fraction of the medicament powder entrained in the first flow of air as it passes through the conduit 404.
  • the first chamber 402 is arranged to draw air external to the device 40 into the first chamber 402 through the first inlet grate 42 and first chamber inlet 402A.
  • the second chamber 408 is arranged to draw air external to the device 40 into the second chamber 408 through the second inlet grate 48 and second chamber inlet 408A.
  • the first flow of air entrained with medicament powder exits the device 40 through the mouthpiece 49.
  • first inlet grate 42 and the first chamber inlet 402A are located on one, or a first, side of main body 450, and that the separate second inlet grate 48 and second chamber inlet 408A are located on a second side of the main body 450 that is separate to, or away from, the first side.
  • the second inlet grate 48 and second chamber inlet 408A are on substantially the opposite side of the main body 450 to the first inlet grate 42 and the first chamber inlet 402A - that is, separated by substantially 180 degrees or a half-circle or half-turn.
  • the main body could be arranged so that the first and second sides are separated by for example a quarter-turn or similar (orthogonal to one another).
  • first and second sides are separated by for example a quarter-turn or similar (orthogonal to one another).
  • grate in this specification is intended to cover a single simple aperture, or an aperture or apertures that comprise a framework of parallel or crossed bars, or a series of smaller apertures grouped together to produce a similar effect to a single larger aperture.
  • a fourth embodiment of dispenser device 50 is shown in figure 5C.
  • the dispenser device 50 comprises a manifold 500, which is shown separately in figures 5A and 5B.
  • the main body 550 of the dispenser device 50 has an inlet grate 52 and a mouthpiece 59.
  • the inlet grate 52 is in fluid connection with both first and second chamber inlets 502A, 508A on the manifold 500.
  • the dividing wall 520 abuts the inlet grate 52.
  • the mouthpiece 59 is in fluid connection with the conduit outlet 504B.
  • the manifold 500 comprises a first chamber 502 comprising a first chamber inlet 502A and a first chamber outlet 502B.
  • the manifold 500 also has a conduit 504 having a conduit inlet 504A and a conduit outlet 504B.
  • the conduit 504 has an elongate length between the conduit inlet 504A and the conduit outlet 504B.
  • a pair of bleed inlets 506 are arranged side-by-side in a wall of the conduit 504 outside of the first chamber 502. In this example, the pair of bleed inlets 506 are located partway (about halfway) along the length of the conduit 504, between the conduit inlet and the conduit outlet.
  • Each of the bleed inlets 506 defines an oblong shaped opening in the wall of the conduit 504. In this embodiment, the bleed inlet has a width across the opening greater than the depth of the bleed inlet through the wall of the conduit.
  • the manifold 500 further comprises a second chamber 508 having a second chamber inlet 508A.
  • the second chamber 508 is in fluid connection with the pair of bleed inlets 506.
  • the first chamber 502 and second chamber 508 are located side-by-side (i.e. adjacent to one another) on the same side of the conduit 504.
  • the first and second chambers 502, 508 are separated from each other by a dividing wall 520.
  • the direction of each the bleed inlets 506 into the conduit 504 is generally in line with the direction of the first chamber inlet 508A into the first chamber 502 and to the direction of the second chamber inlet 508A into the second chamber 508.
  • the first chamber 502 is arranged to direct a first flow of air (not shown) from the first chamber inlet 502A to the first chamber outlet 502B, where it passes through a supply of medicament powder (not shown) positioned next to both the first chamber outlet 502B and conduit inlet 504A.
  • a supply of medicament powder not shown
  • the first flow of air entrained with medicament powder then flows into the conduit inlet 504A and along the conduit 504 to the conduit outlet 504B, where it exits the manifold 500.
  • the second chamber 508 is arranged to direct a second flow of air (not shown) from the second chamber inlet 508A to the bleed inlets 506.
  • the bleed inlets 506 are configured to direct the second flow of air into the conduit 504 to disruptively impact the first flow of air entrained with medicament powder as it flows through the conduit 504. This advantageously increases the FP fraction of the medicament powder entrained in the first flow of air as it passes through the conduit 504.
  • the first chamber 502 is arranged to draw air external to the device 50 into the first chamber 502 through the inlet grate 52 and first chamber inlet 502A.
  • the second chamber 508 is arranged to draw air external to the device 50 into the second chamber 508 through the inlet grate 52 and second chamber inlet 508A.
  • the dividing wall 520 acts to divide the air drawn in through the inlet grate 52 into separate first and second air flows (not shown) in the first and second chambers 502, 508 respectively.
  • the first flow of air entrained with medicament powder exits the device 50 through the mouthpiece 59.
  • the first chamber outlets (102B, 202B, 302B, 402B, 502B) and the conduit inlets (104A, 204A, 304A, 404A, 504A) comprise apertures with a baffle (numbered 120, 220, 320, 420, 520 for each of the embodiments respectively) across the aperture that forms the inlets and outlets.
  • the baffles are integrally formed with the material through which the apertures pass.
  • the baffles are formed as narrow bars or extensions that substantially quadrisect the substantially oval shapes of the apertures.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Nozzles (AREA)

Abstract

La présente invention concerne un distributeur de médicament qui comprend : un corps principal ; un collecteur à l'intérieur du corps comprenant une chambre avec une entrée et une sortie, la chambre dirigeant de l'air de l'entrée vers la sortie ; un conduit ayant une entrée et une sortie, la sortie de chambre et l'entrée de conduit étant agencées de sorte que le flux d'air est dirigé de la sortie de chambre vers l'entrée de conduit par l'intermédiaire d'une poudre de médicament pour entraîner la poudre et fournir un écoulement d'air entraîné par poudre à travers le conduit ; et une entrée de purge dans une paroi du conduit à l'extérieur de la chambre qui dirige un second flux d'air à l'intérieur du conduit pour affecter le flux d'air ; le corps principal ayant des première et seconde entrées séparées qui permettent le passage de l'air de l'extérieur du corps principal vers l'intérieur, la première entrée de corps principal étant en communication fluidique avec l'entrée de chambre, la seconde entrée de corps principal étant en communication fluidique avec l'entrée de purge.
PCT/IB2023/054444 2022-04-29 2023-04-28 Distributeur de médicament servant à disperser des médicaments en poudre sèche WO2023209665A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17/732,853 2022-04-29
US17/732,853 US20230347079A1 (en) 2022-04-29 2022-04-29 Manifold
GB2206312.7A GB2618145A (en) 2022-04-29 2022-04-29 Manifold
GB2206312.7 2022-04-29

Publications (1)

Publication Number Publication Date
WO2023209665A1 true WO2023209665A1 (fr) 2023-11-02

Family

ID=86605017

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2023/054444 WO2023209665A1 (fr) 2022-04-29 2023-04-28 Distributeur de médicament servant à disperser des médicaments en poudre sèche

Country Status (1)

Country Link
WO (1) WO2023209665A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030183229A1 (en) * 1994-09-21 2003-10-02 Inhale Therapeutic Systems, A Corporation Of The State Of California Apparatus and method for dispersing dry powder medicaments
US20090314291A1 (en) * 2005-12-12 2009-12-24 Anderson Gregor John Mclennan Medicament dispenser
US20110094507A1 (en) * 2008-01-24 2011-04-28 Vectura Delivery Devices Limited Inhaler

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030183229A1 (en) * 1994-09-21 2003-10-02 Inhale Therapeutic Systems, A Corporation Of The State Of California Apparatus and method for dispersing dry powder medicaments
US20090314291A1 (en) * 2005-12-12 2009-12-24 Anderson Gregor John Mclennan Medicament dispenser
US20110094507A1 (en) * 2008-01-24 2011-04-28 Vectura Delivery Devices Limited Inhaler

Similar Documents

Publication Publication Date Title
EP2240228B1 (fr) Inhalateur de poudre sèche
JP4718757B2 (ja) 着脱可能な液滴放出カートリッジを備えた吸入器
CA2529069C (fr) Inhalateur de poudre seche et methode pour l'inhalation pulmonaire d'une poudre seche
FI64893B (fi) Inhalationsanordning
EP0938907B1 (fr) Inhalateur
US6286507B1 (en) Single dose inhaler I
CA2147260C (fr) Inhalateur de medicaments en poudre
US20180369513A1 (en) Powder dispersion devices and methods
CN106535968B (zh) 粉末吸入器和粉末吸入组
US5692496A (en) Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
CA2507794A1 (fr) Inhalateur pour administration transpulmonaire
CZ5699A3 (cs) Nosná jednotka pro uložení puchýřkové karty
JPH06501176A (ja) 乾燥粉薬吸入器
PT1351734E (pt) Inalador de pó seco
KR20010102405A (ko) 정량식 저속 분무 흡입기
JP2012527262A5 (fr)
EP3397329B1 (fr) Écoulement d'air dans une tête de nébuliseur
KR20200090802A (ko) 신형 드라이 파우더 흡입장치
WO2023209665A1 (fr) Distributeur de médicament servant à disperser des médicaments en poudre sèche
CN111356495A (zh) 粉末释放装置及方法
US20230347079A1 (en) Manifold
GB2618145A (en) Manifold
CN111989132B (zh) 干粉末吸入器
JP2019521828A (ja) 散乱チャンバを有し呼吸を支援するマスク、システム、および方法
EP3151893B3 (fr) Inhalateur de poudre sèche

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23727074

Country of ref document: EP

Kind code of ref document: A1