WO2023205174A1 - Tables et ensembles d'intervention pour animaux - Google Patents

Tables et ensembles d'intervention pour animaux Download PDF

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Publication number
WO2023205174A1
WO2023205174A1 PCT/US2023/018981 US2023018981W WO2023205174A1 WO 2023205174 A1 WO2023205174 A1 WO 2023205174A1 US 2023018981 W US2023018981 W US 2023018981W WO 2023205174 A1 WO2023205174 A1 WO 2023205174A1
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WO
WIPO (PCT)
Prior art keywords
plastic
major surface
animal
animal procedure
covered
Prior art date
Application number
PCT/US2023/018981
Other languages
English (en)
Inventor
Robert M. Kaiser
Original Assignee
Kaiser Hepatocyte Isolation, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaiser Hepatocyte Isolation, Llc filed Critical Kaiser Hepatocyte Isolation, Llc
Publication of WO2023205174A1 publication Critical patent/WO2023205174A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals
    • C08L59/02—Polyacetals containing polyoxymethylene sequences only

Definitions

  • the present disclosure relates to animal procedure tables for performing various procedures on small anmals, such as rodents.
  • morgue tables are not designed to achieve all three modes of movement (pitch, yaw, and roll), and are not suitable for bench-top or biological sample cabinet (BSC) usage.
  • Drain conduits must be provided to route fluids to a separate drain unit.
  • the labor required, and the lengths of these conduits add greatly to the capital and operating expense, especially when the procedure table is separated from the drain by long distance.
  • These disadvantages may cause frequent maintenance headaches, and in the worse case outright table downtime for extended periods.
  • Cleaning and maintenance of the known procedure tables, drainage conduits, and drains may take away time that otherwise could be used in research.
  • a first aspect of the disclosure are animal procedure tables comprising (or consisting essentially of, or consisting of): a) a plastic or plastic-covered board (preferably polyoxymethylene homopolymer (Delrin® or other)); (machined, molded, printed, or otherwise formed); (optionally one-piece or multiple pieces fitted together) having first and second major surfaces and a through-hole extending from the first major surface to the second major surface serving as a drain, the drain positioned in a non-central location of the plastic board or plastic-covered board; b) the first major surface having a continuous, single recessed work area shaped to allow fluids (blood, buffer, perfusate, and the like) to gravity-flow or otherwise be directed (for example, pushed) into a collector in fluid and structural communication with the drain, the continuous, single work area being a major portion of the first major surface (certain embodiments may comprise a collector adapter, as described herein, whereby the collector removably attaches to the collector adapter, and the
  • animal refers primarily to small animals, such as rodents used in research settings, wherein the entire device may be placed in a BSC, although conceivably the tables described herein could be scaled up for larger animal use.
  • Plastic means polymeric, filled or unfilled with one or more fillers, whether active or passive fillers.
  • Plastic-coated means the boards may comprise a metal core with a plastic material coated or layered thereon so that the plastic comprises at least the continuous, single recessed work area.
  • the plastic or plastic-covered board may be formed by a procedure selected from one or more subtractive processes, one or more additive processes, one or more molding processes (for example, but not limted to, injection molding extrusion, rotational molding, and blow molding), or a combination thereof.
  • the stand is a tripod allowing the plastic or plastic-covered board to achieve all three modes of movement (pitch, yaw, and roll).
  • the drain may be circular having threads and the collector may be a transparent or partially transparent bottle having a circular, mating threaded opening. In certain embodiments the bottle may be a transparent plastic.
  • FIG. 1 is a schematic perspective view of one embodiment in accordance with the present disclosure, illustrating how the tables may be used with a small animal;
  • FIG. 2 is another perspective view of the embodiment of FIG. 1;
  • FIGS. 3 and 4 are schematic perspective views of another animal procedure table embodiment in accordance wih the present disclosure.
  • FIGS. 5, 6, 7, and 8 are perspective schematic illustration views of one embodiment of a table adapter in accordance with the present disclosure used in certain embodiments to connect an animal procedure table to a stand;
  • FIGS. 9 and 10 are bottom and top plan schematic illustration views, respectively, of the table adapter illustrated in FIGS. 5-8;
  • FIGS. 11 and 12 are schematic end and side elevation views, respectively, of the table adapter illustrated schematically in FIGS. 5-10;
  • FIGS. 13 and 14 are perspective schematic illustration views, FIGS. 15 and 16 are bottom and top plan schematic illustration views, respectively, and
  • FIGS. 17 and 18 are schematic side elevation views of one embodiment of a collector adapter in accordance with the present disclosure used in certain embodiments to connect a collector (bottle or other) to an animal procedure table;
  • FIGS. 19, 20, 21, and 22 are perspective schematic illustration views
  • FIGS. 23 and 24 are bottom and top plan schematic illustration views, respectively
  • FIGS. 25 and 26 are schematic end and side elevation views, respectively, of another embodiment of a table adapter in accordance with the present disclosure used in certain embodiments to connect an animal procedure table to a stand;
  • FIGS. 27 and 29 are schematic perspective views
  • FIG. 28 is a schematic side elevation view
  • FIG. 31 a schematic end elevation view
  • FIG. 30 a schematic top plan view
  • FIG. 32 is a schematic bottom plan view
  • FIG. 33 is a schematic exploded view of one animal procedure assembly in accordance with the present disclosure
  • FIGS. 34 and 36 are schematic perspective views
  • FIG. 35 is a schematic side elevation view
  • FIG. 38 a schematic end elevation view
  • FIG. 37 a schematic top plan view
  • FIG. 39 is a schematic bottom plan view
  • FIG. 40 is a schematic exploded view of another animal procedure assembly in accordance with the present disclosure
  • FIGS. 41 and 42 are schematic perspective views
  • FIGS. 43 and 44 are top and bottom plan views, respectively
  • FIGS. 45 and 46 are end and side elevation views, respectively, of the animal procedure table of the animal procedure assembly illustrated schematically in FIGS. 27-33;
  • FIGS. 47 and 48 are schematic perspective views
  • FIGS. 49 and 50 are top and bottom plan views, respectively
  • FIGS. 51 and 52 are end and side elevation views, respectively, of the animal procedure table of the animal procedure assembly illustrated schematically in FIGS. 34-40; and
  • FIGS. 53 and 54 are perspective schematic illustration views
  • FIGS. 55 and 56 are top and bottom plan schematic illustration views, respectively
  • FIGS. 57 and 58 are schematic side elevation views of another embodiment of a collector adapter in accordance with the present disclosure used in certain embodiments to connect a collector (bottle or other) to an animal procedure table.
  • R RL + k*(RU-RL), wherein k is a variable ranging from 1% to 100% with a 1% increment, i.e., k is 1%, 2%, 3%, 4%, 5%, . . . , 50%, 51%, 52%, . . . , 95%, 96%, 97%, 98%, 99%, or 100%.
  • any numerical range defined by two R numbers as defined in the above is also specifically disclosed.
  • Certain animal procedure assemblies may be devoid of one or both adapters described herein.
  • the term “comprising” and derivatives thereof is not intended to exclude the presence of any additional component, step or procedure, whether or not the same is disclosed herein.
  • all systems, processes, and compositions claimed herein through use of the term “comprising” may include any additional component, step, additive, adjuvant, or compound whether monomeric, oligomeric, polymeric or otherwise, unless stated to the contrary.
  • the term, “consisting essentially of’ excludes from the scope of any succeeding recitation any other component, step or procedure, excepting those that are not essential to operability.
  • the term “consisting of” excludes any component, step or procedure not specifically delineated or listed.
  • the term “a” includes a single item as well as multiple items.
  • the stand may be a tripod allowing the plastic or plastic-covered board to achieve all three modes of movement (pitch, yaw, and roll).
  • One suitable tripod may be that known under the trade designation Manfrotto MTPIXI-B, which features versatile, lightweight stainless steel, and portable construction, as well as a universal mounting system.
  • a user may use the tripod with most DSLR cameras, and with the help of various nozzles, users can attach a camera, GoPro® brand compact action camera or other brand action camera, or smartphone.
  • a button mechanism allows mounting and fixing a ball head with a quick movement.
  • a button when pressed, allows a hinge to move freely and very easily.
  • tripods When the button is down, the hinge is automatically locked in the selected position. Rubber feet ensure a stable fixation on any surface. 360 degrees panoramic rotation is allowed.
  • Other suitable tripods may incude adjustable length lengths, and may be made of aluminum.
  • Another suitable tripod may be that known under the trade designation SLIK Mini-Pro V, which when equipped with a ball attachment allows pitch, yaw, and roll movements, and features a suction cup at the bottom of a central column for additional stability.
  • a handle may be used to control the frame.
  • Certain useful tripods may include an integrated ball head or mini -ball head, which allows adjustment in pitch, yaw, and roll as the user wishes.
  • Tripods of this nature may be used to mount almost any animal procedure table thereto, or camera, smartphone, or other device, using a 14-20 screw (where 'A is the nominal width in inches of the screw, and 20 is threads per inch) or other size screw.
  • the plastic or plastic-covered board may have a first perimeter shape selected from rectangular, triangular, oval, and circular, and a first plan area ranging from about 80 in 2 to about 120 in 2 (from about 520 cm 2 to about 770 cm 2 ), or from about 90 in 2 to about 110 in 2 (from about 590 cm 2 to about 700 cm 2 ).
  • the continuous, single recessed work area has a second perimeter shape selected from rectangular, triangular, oval, and circular, the second perimeter shape being same as or different than the first perimeter shape, and a second plan area smaller than the first plan area.
  • the second plan area may be 10 percent smaller, or 20 percent smaller, or 30 percent smaller, or 40 percent smaller, or 50 percent smaller than the first plan area.
  • the continuous, single recessed work area may have a depth ranging from about 10 percent to about 50 percent of the thickness of the plastic or plastic-covered board, or from about 15 to about 35 percent of the thickness of the plastic or plastic-covered board.
  • the depth may be uniform or nonuniform; example of nonuniform depth include those where the depth increases from the sides of the board toward the centerline of the board, and embodiments where the depth is greatest at the drain but less in other areas.
  • the board or table may comprise, on its non-working major side, a grid of plastic members. The grid may be in the form of vertical panels with arcuate edges connecting the panels with the second major surface of the board or table.
  • the drain hole may be circular having threads and the collector may be a transparent or partially transparent bottle having a circular, mating threaded opening.
  • the bottle may be a rigid or flexible transparent plastic, for example polyethylene terephthalate (PET), polyvinyl chloride (PVC), polypropylene (PP), polystyrene (PS), polycarbonate (PC), polymethyl methacrylate (PMMA), polyamide, polyethylene, polytetrafluoroethylene (PTFE), copolymers, mixtures, and layered versions of two or more of these, and the like.
  • PET polyethylene terephthalate
  • PVC polyvinyl chloride
  • PP polypropylene
  • PS polystyrene
  • PC polycarbonate
  • PMMA polymethyl methacrylate
  • polyamide polyethylene, polytetrafluoroethylene (PTFE), copolymers, mixtures, and layered versions of two or more of these, and the like.
  • the collector may be glass, such as that known under the trade designation PYREX, or other glassware such as E-glass, S-glass, and the like.
  • the collector may be a plastic bag comprising flexible plastic such as polyethylene, the bag having a rigid attachment spount that may be threaded or snapped onto a table or table adapter.
  • the one or more metal posts may be adjustable in height away from the plastic or plastic-covered board, for example by threaded adjustment, friction fit adjustment, telescoping adjustment, and the like. The metal posts may also be extended by securing a metal or other material extension thereon.
  • the one or more metal posts may comprise first and second metal posts positioned on opposite side of the drain, third and fourth metal posts positioned further away from the drain than the first and second metal posts, and fifth and sixth metal posts positioned on opposites sides of a utility cutout portion of the board positioned distal from the drain.
  • Certain animal procedure assembly embodiments described herein may comprise a collector adapter and a table adapter, as further explained in reference to the drawings.
  • the collector adapter may allow a user to employ different size collectors, or collectors with different size openings, with the same table.
  • Table adapters are designed for easy and quick attachment/detachment of a stand (tripod or other).
  • FIG. 1 is a high-level schematic perspective view, general illustrating the top of one animal procedure assembly embodiment 100 in accordance with the present disclosure
  • FIG. 2 is a high-level schematic perspective view, generally illustrating the bottom of embodiment 100.
  • Embodiment 100 includes an 8 inch x 12 inch (20 cm x 30 cm) plastic or plastic-covered board or table 2 having a first major surface of 4, a second major surface 6, and a continuous, single recessed work area 8.
  • Embodiment 100 includes a drain through-hole 10 (also referred to herein as simply a drain) extending from the continuous, single recessed work area 8 to second major surface 6, which allows fluids to flow into a detachable container 12, in embodiment 100 a transparent plastic bottle.
  • a drain through-hole 10 also referred to herein as simply a drain
  • Second major surface 6 of table 2 of embodiment 100 includes a neck 14 formed in the plastic and in fluid communication with drain 10.
  • Embodiment 100 includes a tripod 16 having three legs 17A, 17B, and 17C positioned about 120 degrees apart, and (as better illustrated in FIG. 2) an optional center leg 26 for extra support.
  • a suction cup 28 on bottom of central leg 26 may be provided as an option for extra stability.
  • a major portion 22 of first major surface 4 is illustrated, as is a minor portion 24 of first major surface 4, and embodiment 100 includes first and second metal posts 18, 20. Legs 17A-C may be folded inward for storage.
  • FIG. 2 further illustrates length adjustments 30A, 30B, and 30C for legs 17A, 17B, and 17C, respectively, where the length adjustments in embodiment 100 are tent pole twist adjustments, but any other adjustment mechanism, such as threaded bolts with wing nuts, would be satisfactory.
  • Embodiment 100 includes a threaded locking/unlocking nut 32 for attaching various attachments to tripod 16, such as a ball connector 34 in this embodiment and a locking/unlocking nut 36 for ball connector 34.
  • a centrally located male or female attachment 38 is configured to accept a mating attachment of tripod 16, allowing the plastic or plastic- covered board or table 2 to achieve all three modes of movement (pitch, yaw, and roll).
  • a female or male extension 40 is provided to mate with centrally located male or female attachment 38.
  • a cotter pin 29 is provided in embodiment 100 for securing male or female attachment 38 to female or male extension 40.
  • a platform 42 may be provided for supporting female or male extension 40.
  • FIGS. 3 and 4 illustrate another embodiment 200 having many features in common with embodiment 100.
  • Embodiment 200 features, in addition to first and second metal posts 18, 20, third, fourth, fifth, and sixth metal posts 50, 52, 54, 56 and a cutout portion 58 for anesthesia conduits, perfusion conduits, and the like.
  • Through holes 60, 62, 64, and 66 are provided for metal posts 50, 52, 54, and 56, respectively, and threads 68 are provided on neck 14.
  • FIGS. 5, 6, 7, and 8 are perspective schematic illustration views of one embodiment of a table adapter 70 in accordance with the present disclosure used in certain embodiments to connect an animal procedure table to a stand, for example, but not limited to, a tripod.
  • Embodiment 70 includes a body 72 having a bottom surface 74 and a top surface 76. Bottom surface 74 faces a stand, while top surface 76 faces the second major surface 6 of table 2 when connected thereto.
  • Embodiment 70 further includes a connector element 78, a box-like component (which may be solid or hollow), having a male part 80 which is configured to slide or snap into a female part of a stand or tripod connector (not illustrated) and four sides 82.
  • Embodiment 70 also includes arcuate flange connections 84 where connector element 78 connects to body 72.
  • Sliding or snap connector elements 86 are provided in this embodiment for removably connecting table adapter 70 to a stand or tripod.
  • Through holes 88 are provided for threaded connectors that allow connection of table adapter 70 to an animal procedure table.
  • Lightening and alignment through holes 90, 92 in body 72 allow alignment of table adapter 70 to an animal procedure table, while reducing weight. Short or end edge 94 of body 72 and long or side edge 96 of body 72 are further noted.
  • FIGS. 9 and 10 are bottom and top plan schematic illustration views, respectively, of the table adapter 70 illustrated in FIGS. 5-8, while FIGS. 11 and 12 are schematic end and side elevation views, respectively, of table adapter 70 illustrated schematically in FIGS. 5-10.
  • FIGS. 13 and 14 are perspective schematic illustration views
  • FIGS. 15 and 16 are bottom and top plan schematic illustration views, respectively
  • FIGS. 17 and 18 are schematic side elevation views of one embodiment 102 of a collector adapter in accordance with the present disclosure used in certain assembly embodiments to connect a collector 12 to an animal procedure table described herein.
  • Collector adapter 102 comprises a generally triangular body 104 having three sides 106, a planar surface or “face” 108 that is configured to face the collector when a collector is removably attached to collector adapter 102, and a planar surface or “face” 110 that is configured to face the table when collector adapter 102 is removably attached to a table.
  • Collector adapter embodiment 102 further includes a female threaded hole 112 to mate with male threads on collectors, and a female threaded hole 114 to mate with male threads on a table.
  • Three through holes 116 are provided in embodiment 102 for threaded fittings for removably attaching collector adapter 102 to a table using threaded member (bolts, screws, and the like).
  • Generally triangular body 104 also features three vertices 118.
  • FIGS. 19, 20, 21, and 22 are perspective schematic illustration views
  • FIGS. 23 and 24 are bottom and top plan schematic illustration views, respectively
  • FIGS. 25 and 26 are schematic end and side elevation views, respectively, of another embodiment 120 of a table adapter in accordance with the present disclosure used in certain embodiments to connect an animal procedure table to a stand.
  • Table adapter 120 includes a body 122, vertical support panels 124 that are parallel to the long axis of table adapter 120, and vertical support panels 126 that are parallel to the short axis. This forms a grid, with arcuate portions 132, 134 serving as transitions between panels 124, 126 and a bottom surface 130 of table adapter 120.
  • Table adapter embodiment 120 may be lighter (weigh less) than embodiment 70, but because it has a more complicated shape embodiment 120 may be manufactured using one or more additive processes, such as 3D printing or other process described herein, using one or more plastic materials.
  • FIGS. 27 and 29 are schematic perspective views
  • FIG. 28 is a schematic side elevation view
  • FIG. 31 is a schematic end elevation view
  • FIG. 30 is a schematic top plan view
  • FIG. 32 is a schematic bottom plan view
  • FIG. 33 is a schematic exploded view of one animal procedure assembly 140 in accordance with the present disclosure.
  • Animal procedure assembly 140 includes an animal procedure table 142 connected via table adapter 70 to a ball connector 34 via a slide or snap connector 144 having surfaces that mate to corresponding slide or snap connector elements 86 on table adapter 70 as previous described.
  • FIGS. 41-46 As illustrated schematically in exploded view of FIG.
  • embodiment 140 includes sleeves or guides 146 for metal posts 18, 20, 50, 52, 54, 56.
  • each sleeve or guide 146 has both internal and external threads, where the external threads are forced into the table plastic material and held in the table by friction threaded fittings, while the internal threads mate with external threads on lower portions of each metal post 18, 20, 50, 52, 54, 56.
  • Threaded connectors 148 are provided for connecting connector adapter 102 to table 142.
  • Another set of threaded connectors 149 are provided for connecting table adapter 70 to table 142.
  • FIGS. 34 and 36 are schematic perspective views, FIG. 35 is a schematic side elevation view, FIG. 38 is a schematic end elevation view, FIG. 37 is a schematic top plan view, FIG. 39 is a schematic bottom plan view, and FIG. 40 is a schematic exploded view of another animal procedure assembly 150 in accordance with the present disclosure.
  • Animal procedure assembly 150 is similar to embodiment 140 but differs by employing a different animal procedure table 202, collector adapter 160, and table adapter 120.
  • Animal procedure table 202 is described in reference to FIGS. 47-52 herein, while collector adapter 160 is described with reference to FIGS. 53-58 herein.
  • FIGS. 41 and 42 are schematic perspective views
  • FIGS. 43 and 44 are top and bottom plan views, respectively
  • FIGS. 45 and 46 are side and end elevation views, respectively, of the animal procedure table 142 of the animal procedure assembly 140 illustrated schematically in FIGS. 27-33.
  • table embodiment 142 holes for metal posts 18, 20, 50, 42, 54, 56 are provided, as well as an alignment ring 192 for collector adapter 102, and alignment rings 194 for table adapter 70.
  • Holes 196 for threaded members to connect table adapter 70 to table 142 are provided, as well as holes 198 for threaded members to connect collector adapter 102 to table 142.
  • FIGS. 47 and 48 are schematic perspective views
  • FIGS. 49 and 50 are top and bottom plan views, respectively
  • FIGS. 51 and 52 are side and end elevation views, respectively, of the animal procedure table 202 of the animal procedure assembly 150 illustrated schematically in FIGS. 34-40.
  • Animal procedure table 202 includes sockets 204 for threaded members to connect metal posts 18, 20, 50, 52, 54, 56 to table 202, as well as sockets 206 for threaded members to connect table adapter 120 to table 202.
  • Animal procedure table 202 differs in structure from animal procedure table 142 primarily in two features.
  • the first structural difference is the inclusion of a support grid 208 on non-working surface 6 extending the entire length and width of table 202, where support grid 208 comprises a series of length- wise panels and a series of cross-width panels forming a checkerboard pattern with recesses.
  • the first structural difference necessitates the second structural difference, the inclusion of sockets 204, 210, and 212.
  • sockets 204 receive threaded sleeves 146.
  • Sockets 210 receive threaded members 149 for attaching table adapter 120 to table 202
  • sockets 212 receive threaded members 151 for attaching collector adapter 160 to table 202.
  • FIGS. 53 and 54 are perspective schematic illustration views
  • FIGS. 55 and 56 are bottom and top plan schematic illustration views, respectively
  • FIGS. 57 and 58 are schematic side elevation views of another embodiment 160 of a collector adapter in accordance with the present disclosure used in certain embodiments to connect a collector (bottle or other) to an animal procedure table such as embodiment 150.
  • Collector adapter 160 includes a generally triangular body 164, three sides 166 of body 164 which define a recess 168 of generally triangular body 164.
  • Embodiment 160 includes a centrally positioned, internally threaded cylindrical connector 170 supported by three stmts 172. Internally threaded cylindrical connector 170 includes internal threads 174.
  • a through hole 176 is provided for fluidly connecting with table 202, and through holes 178 function with threaded fittings 151 for connecting collector adapter 160 to table 202.
  • a bottom face 180 of generally triangular body 164 is configured to be adjacent non-working surface 6 of table 202.
  • Suitable metals for the metal posts include stainless steels, for example, but not limited to, 304, 316, as well as titanium alloys, aluminum alloys, copper, copper alloys, and the like. High-strength materials like C-110 and C-125 metallurgies that are NACE qualified may be employed.
  • NACE refers to the corrosion prevention organization formerly known as the National Association of Corrosion Engineers, now operating under the name NACE International, Houston, Texas.
  • the skilled artisan having knowledge of the particular application, temperatures, and available materials, will be able design the most cost effective, safe, and operable components for each particular application without undue experimentation.
  • the materials of construction of the tables, table adapters, collector adapters, collectors, stands, and other members may comprise any moldable or printable plastic (polymeric) material, or ceramic material, or metallic material, or combination thereof that is approved for use in biomedical research facilities.
  • the members may comprise a single material, or combination of materials.
  • the members may comprise more than one layer of material, and each layer may be the same or different.
  • the polymeric materials may be filled with various fillers, extenders, pigments, and other additives. In embodiments consisting essentially of moldable and/or biocompatible polymeric material, these fillers, extenders, pigments, and other additives may be present in limited amounts to the extent necessary to substantially exceed minimum safety and effectiveness standards.
  • Suitable polymeric materials include thermoplastics, thermosetting polymers, elastomers, and thermoplastic elastomers.
  • the polymeric materials may comprise co-polymers, ter-polymers, and blends of two or more chemical types of polymers, or blends of two or more polymers of the same chemical type, for example, a blend of two thermoplastics having different molecular weights.
  • Examples of specific polymers include light-curable polymer-based resins designed for the fabrication of parts by additive manufacturing, such as acetals, polyacrylics, polyvinyls, polyvinyl alcohols, and the like.
  • An example of a suitable polymeric material is a durable fade- proof acrylic that retains its shape and color for at least four- five years.
  • Other polymeric materials that may be useful include nitinol, silicone, polyamides, polyimides, PTFE, e-PTFE, polypropylene, polyurethane, polycarbonate, polyethylene terephthalate, polyvinylidene fluoride and combinations thereof.
  • the plastic or plastic-covered board may be formed by a procedure selected from one or more subtractive processes, one or more additive processes, one or more molding processes (for example, but not limited to, injection molding extrusion, rotational molding, and blow molding), or a combination thereof.
  • the one or more substractive processes may be selected from machining operations such as cutting, sanding, knurling, drilling, deformation, facing, and turning, all of which may be computer-aided or non-computer- aided.
  • the one or more additive processes may be selected from rapid prototyping, 3D printing, stereolithography (SLA) printing, near-net or net-shape casting, and combinations thereof.
  • SLA stereolithography
  • the plastic or plastic-covered board may comprise a plastic homopolymer, a plastic copolymer, mixtures thereof, and layered versions thereof, wherein the plastic homopolymer may be unfilled or partially filled with one or more fillers, wherein the plastic copolymer may be unfilled or partially filled with one or more fillers, wherein the filler may be selected from fibrous materials, non-fibrous materials, and mixtures thereof.
  • the plastic homopolymer may be a polyoxymethylene carboxylate having a reaction rate constant for thermal degradation at 222 °C of less than 1% by weight per minute, substantially all polymer chains of the polyoxymethylene carboxylate having the structural formula RiC(O)O(CH2O) n C(O)R2 wherein Ri and R2 are organic radicals having from 1 to about 17 carbon atoms and are independently selected from the group consisting of alkyl, alkylene, cycloalkyl, and aryl, and n is an integer greater than about 500, as described in U.S. Patent Nos. 2,768,994 and 2,998,409, incorporated herein by reference. These specific products are known under the trade designations Delrin® acetal homopolymer, commercially available from duPont.
  • Certain products may be copolymers, where about 1-1.5% of the -CH2O- groups are replaced with -CH2CH2O-.
  • Copolymer resins are commercially available from several manufactures and are known under the trade designations Kocetal® (Kolon Plastics, South Korea), Ultraform® (BASF), Celcon® (Celanese), Ramtal® (Polyram Plastic Industries LTD, Israel), Duracon® (Polyplastic Co., China), Kepitai® (Korean Engineering Plastics Co., LTD), Polypenco® (Quadrant Polypenco, Korea), Tenac® (Asahi Kasei Chemicals Corporation, Japan), and Hostaform® (Celanese).
  • acetal homopolymers and copolymers may also be filled with solid lubricants, glass fibers, polyaramid fibers, colorants, and the like to enhance their structural, bearing and wear properties, and/or simply their appearance.
  • Materials such as glass, PTFE, graphite and oil are all available in standard sizes.
  • the component in question may be integrally molded using special molds, or may be made using additive manufacturing methods, such as 3D printing.
  • one or more molding or printing steps may be required to build up the component to functional length, width, height, and diameter.
  • the methods may include printing steps featuring specific polymers, colors, shapes, software, and the like.
  • 3D printers that may be useful are the 3D printers known under the trade designation Formlabs Form 3B+ and 3BL, available from Formlabs, Millbury, Ohio (USA).
  • Various components such as tables as described herein may be made using a variety of additive and/or subtractive processes, including molding, machining, stamping and like additive processes, and/or subtractive processes such as net-shape casting (or near-net shape casting) using rapid prototype (RP) molds.
  • Net-shape or near-net shape casting methods of making a variety of molds for producing a variety of complex products are summarized in patents assigned to 3D Systems, Inc., Rock Hill, South Carolina, U.S.A., for example U.S. Pat. No. 8,285,411.
  • RP rapid prototype
  • SFF Solid Freeform Fabrication
  • Some SFF techniques include stereolithography, selective deposition modeling, laminated object manufacturing, selective phase area deposition, multi-phase jet solidification, ballistic particle manufacturing, fused deposition modeling, particle deposition, laser sintering, film transfer imaging, and the like.
  • SFF Solid Freeform Fabrication
  • complex parts are produced from a build material in an additive fashion as opposed to conventional fabrication techniques, which are generally subtractive in nature. For example, in most conventional subtractive fabrication techniques material is removed by machining operations or shaped in a die or mold to near net shape and then trimmed.
  • additive fabrication techniques incrementally add portions of a build material to targeted locations, layer by layer, in order to build a complex part.
  • SFF technologies typically utilize a computer graphic representation of a part and a supply of a build material to fabricate the part in successive layers.
  • SFF technologies may dramatically shorten the time to develop prototype parts, can produce limited numbers of parts in rapid manufacturing methods, and may eliminate the need for complex tooling and machining associated with conventional subtractive manufacturing methods, including the need to create molds for custom applications.
  • customized parts can be directly produced from computer graphic data (e.g., computer-aided design (CAD) files) in SFF techniques.
  • CAD computer-aided design
  • structures are formed in a layer by layer manner by solidifying or curing successive layers of a build material.
  • a tightly focused beam of energy typically in the ultraviolet radiation band, is scanned across sequential layers of a liquid photopolymer resin to selectively cure resin of each layer to form a multilayered part.
  • a tightly focused beam of energy such as a laser beam
  • melt powder such as a metal or ceramic powder
  • a build material is jetted or dropped in discrete droplets, or extruded through a nozzle, such that the build material becomes relatively rigid upon a change in temperature and/or exposure to actinic radiation in order to build up a three-dimensional part in a layerwise fashion.
  • FTI film transfer imaging
  • a film transfers a thin coat of resin to an image plane area where portions of the resin corresponding to the cross-sectional layer of the part are selectively cured with actinic radiation to form one layer of a multilayer part.
  • Certain SFF techniques require the part be suspended from a supporting surface such as a build pad, a platform, or the like using supports that join the part to the supporting surface.
  • Prior art methods for generating supports are described in U.S. Patent Nos. 5,595,703; 6,558,606; and 6,797,351.
  • the Internet website of Quickparts.com, Inc., Atlanta, GA, a subsidiary of 3D Systems Inc. has more information on some of these techniques and materials that may be used.
  • Methods of making apparatus of the present disclosure using additive manufacturing may comprise scanning a previously made example device employing a laser scanning appliance to produce a pointcloud image of a device, uploading the pointcloud image to a computer having one or more design software programs loaded thereon or available remotely through an Internet connection, and producing a software version of apparatus from the pointcloud image.
  • the software version of the device may then be uploaded to a 3D printer, followed by 3D printing the device or portions thereof.
  • Laser scanning images is a well- established practice in the medical industry. See for example the laser scanners available from Laser Design, Minneapolis, Minnesota (U.S.A.). See also U.S. Patent Nos. 7,184,150; 7,153,135; and 9,522,054.
  • a 3D rendering may be made from a 2D image, such as a photograph or 2D drawing of a device. See for example U.S. Patent Nos. 8,165,711 and 8,605,136. Imaging equipment, CAD/CAM and imaging analysis software are available from various sources, including 3 Shape, Renishaw, 3M, and others.
  • the various components need not have specific shapes or arrangements as illustrated in the drawings, but rather could take any shape, such as a box or cube shape, elliptical, triangular, prism-shaped, hemispherical or semi-hemispherical-shaped (dome-shaped), or combination thereof and the like, as long as the apparatus performs the desired range of movements.
  • the board cross-section and plan shape need not be rectangular, but may be arcuate, such as semicircular, oval, and the like. It will be understood that such embodiments are part of this disclosure and deemed with in the claims.
  • one or more of the various components may be ornamented with various ornamentation produced in various ways (for example stamping or engraving, or raised features such as reflectors, reflective tape), such as facility designs, operating company designs, logos, letters, words, nicknames (for example KAISER, and the like).
  • Animal procedure tables of the present disclosure may include optional hand-holds, which may be machined or formed to have easy- to-grasp features for fingers, or may have rubber grips shaped and adorned with ornamental features, such as raised knobby gripper patterns.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Husbandry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Housing For Livestock And Birds (AREA)

Abstract

Tables et ensembles d'intervention pour animaux. Les tables présentent des première et seconde surfaces principales et un trou traversant s'étendant de la première surface principale à la seconde surface principale servant de trou de drainage, le trou de drainage étant positionné dans un emplacement non central de la table. La première surface principale présente une zone de travail continue en creux unique mise en forme pour permettre à des fluides de s'écouler par gravité ou autrement d'être dirigés dans un collecteur en communication fluidique et structurelle avec le trou de drainage, la zone de travail continue unique étant une partie principale de la première surface principale. Un ou plusieurs montants s'étendent à l'opposé de la table à partir d'une partie mineure de la première surface principale. La seconde surface principale présente une fixation mâle ou femelle située au centre conçue pour accepter une fixation d'accouplement d'un support permettant à la table d'effectuer un mouvement de roulis, de tangage, et de lacet. Les ensembles comportent une table, un support, et peuvent comporter des adaptateurs de table et de collecteur.
PCT/US2023/018981 2022-04-19 2023-04-18 Tables et ensembles d'intervention pour animaux WO2023205174A1 (fr)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007244762A (ja) * 2006-03-17 2007-09-27 Sanki Eng Co Ltd 解剖台
KR20160094026A (ko) * 2015-01-30 2016-08-09 원정호 동물 부검대
CN108324402A (zh) * 2018-04-03 2018-07-27 华中科技大学苏州脑空间信息研究院 小动物灌流解剖台
CN110353922A (zh) * 2019-07-23 2019-10-22 重庆医药高等专科学校 一种家兔固定台
CN210170217U (zh) * 2019-02-26 2020-03-24 青岛农业大学 动物解剖操作台
CN215228772U (zh) * 2021-03-26 2021-12-21 承德医学院 一种多功能自动化大鼠针灸实验台

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007244762A (ja) * 2006-03-17 2007-09-27 Sanki Eng Co Ltd 解剖台
KR20160094026A (ko) * 2015-01-30 2016-08-09 원정호 동물 부검대
CN108324402A (zh) * 2018-04-03 2018-07-27 华中科技大学苏州脑空间信息研究院 小动物灌流解剖台
CN210170217U (zh) * 2019-02-26 2020-03-24 青岛农业大学 动物解剖操作台
CN110353922A (zh) * 2019-07-23 2019-10-22 重庆医药高等专科学校 一种家兔固定台
CN215228772U (zh) * 2021-03-26 2021-12-21 承德医学院 一种多功能自动化大鼠针灸实验台

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