WO2023202908A1 - Système et méthode de thérapie nasale à haut débit - Google Patents
Système et méthode de thérapie nasale à haut débit Download PDFInfo
- Publication number
- WO2023202908A1 WO2023202908A1 PCT/EP2023/059371 EP2023059371W WO2023202908A1 WO 2023202908 A1 WO2023202908 A1 WO 2023202908A1 EP 2023059371 W EP2023059371 W EP 2023059371W WO 2023202908 A1 WO2023202908 A1 WO 2023202908A1
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- WO
- WIPO (PCT)
- Prior art keywords
- flow rate
- capnograph
- oxygen
- data
- patient
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 60
- 238000000034 method Methods 0.000 title claims description 27
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 106
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 106
- 239000001301 oxygen Substances 0.000 claims abstract description 106
- 239000007789 gas Substances 0.000 claims abstract description 47
- 230000029058 respiratory gaseous exchange Effects 0.000 claims abstract description 33
- 230000036961 partial effect Effects 0.000 claims abstract description 20
- 238000012544 monitoring process Methods 0.000 claims abstract description 17
- 210000003928 nasal cavity Anatomy 0.000 claims abstract description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 226
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 114
- 239000001569 carbon dioxide Substances 0.000 claims description 99
- 238000010790 dilution Methods 0.000 claims description 28
- 239000012895 dilution Substances 0.000 claims description 28
- 238000005259 measurement Methods 0.000 claims description 22
- 230000036387 respiratory rate Effects 0.000 claims description 13
- 206010021079 Hypopnoea Diseases 0.000 claims description 4
- 208000000782 Intrinsic Positive-Pressure Respiration Diseases 0.000 claims description 3
- 238000004590 computer program Methods 0.000 claims description 3
- 244000144985 peep Species 0.000 claims 3
- 239000003570 air Substances 0.000 description 63
- 230000008859 change Effects 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 238000009423 ventilation Methods 0.000 description 11
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 10
- 230000006870 function Effects 0.000 description 9
- 238000005457 optimization Methods 0.000 description 9
- 230000000241 respiratory effect Effects 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 230000008901 benefit Effects 0.000 description 6
- 238000011088 calibration curve Methods 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 230000006866 deterioration Effects 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 230000010412 perfusion Effects 0.000 description 5
- 101100243025 Arabidopsis thaliana PCO2 gene Proteins 0.000 description 4
- 206010020591 Hypercapnia Diseases 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 206010007559 Cardiac failure congestive Diseases 0.000 description 3
- 206010061818 Disease progression Diseases 0.000 description 3
- 206010019280 Heart failures Diseases 0.000 description 3
- 229910003798 SPO2 Inorganic materials 0.000 description 3
- 101100478210 Schizosaccharomyces pombe (strain 972 / ATCC 24843) spo2 gene Proteins 0.000 description 3
- 230000005750 disease progression Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000012804 iterative process Methods 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 210000001331 nose Anatomy 0.000 description 3
- 238000002106 pulse oximetry Methods 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000003434 inspiratory effect Effects 0.000 description 2
- 238000002640 oxygen therapy Methods 0.000 description 2
- 238000006213 oxygenation reaction Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000004852 Lung Injury Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000011191 Pulmonary vascular disease Diseases 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010069363 Traumatic lung injury Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000009246 art therapy Methods 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 230000035565 breathing frequency Effects 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000000122 hyperventilation Diseases 0.000 description 1
- 230000000870 hyperventilation Effects 0.000 description 1
- 208000018875 hypoxemia Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 231100000515 lung injury Toxicity 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000000420 mucociliary effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000011338 personalized therapy Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0666—Nasal cannulas or tubing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes operated by electrical means
- A61M16/022—Control means therefor
- A61M16/024—Control means therefor including calculation means, e.g. using a processor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
- A61M16/122—Preparation of respiratory gases or vapours by mixing different gases with dilution
- A61M16/125—Diluting primary gas with ambient air
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0057—Pumps therefor
- A61M16/0066—Blowers or centrifugal pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0225—Carbon oxides, e.g. Carbon dioxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/202—Blood composition characteristics partial carbon oxide pressure, e.g. partial dioxide pressure (P-CO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/205—Blood composition characteristics partial oxygen pressure (P-O2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/42—Rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/43—Composition of exhalation
- A61M2230/432—Composition of exhalation partial CO2 pressure (P-CO2)
Definitions
- HFNT has two high pressure sources, for an air flow and for an oxygen flow. In combination, these high flows can reach a total of 60 L/min.
- HFNT therapy facilitates removal of CO2 from the airway system, the removal of which is beneficial for effective ventilation. This removal is commonly referred to as CO2 washout.
- CO2 washout is achieved to a certain point, but CO2 washout it not maximized. This is because air and oxygen flows are manually set accordingly to typical therapy values, and the conventional HFNT device provides no means to determine or optimise CO2 washout.
- the present invention permits air and oxygen flows to be adjusted in order to achieve a maximum or target CO2 washout.
- the current disadvantages of HFNT are that (1) it is restricted to stable hypoxemic patients and (2) it does not highly depend on measured CO2 concentrations (e.g. exhaled or transcutaneous) to diagnose and optimize the therapy of these patients.
- various different parameters may be monitored, and these may provide information relating to the type and severity of a range of different diseases and their progression. For example, if a capnograph is used, the slope of different phases is related to asthmatic patients and their severity. Different monitored parameters for example enable differentiation between COPD patients and congestive heart failure patients.
- Fig. 3 shows how a capnograph 40 (or, in practice, the underlying capnograph data) is employed to assist therapy optimization or disease diagnosis.
- the capnograph 40 is a measure of CO2 against time or volume, and may provide many features which may be useful for determining appropriate variations to HFNT settings, either for short term (i.e. immediate) therapy optimization or longer term disease diagnosis and HFNT control as discussed above. Data from a full capnograph 40 or partial capnograph may be used for calibration. The capnograph 40 may also be divided into its partial segments (i.e. phases) and features may be extracted. This information may be used, optionally along with other measurements, to optimize and monitor patient deterioration/improvement and therapy.
- the air flow FnCt) and oxygen flow Fo2(t) may be controlled simultaneously to achieve the target range under various different scenarios:
- the total flow FT is here maintained as a constant, and is the summation of air flow Fo(t) and oxygen flow Fo2(t).
- IE inhalation-exhalation
- Detecting inhalation-exhalation (IE) state in HFNT is critical as it allows the control of the air and oxygen flows to synchronize with the patient’s breathing (e.g. deliver oxygen only during inspiration, deliver different flow values in inspiration and expiration to achieve different pressure support levels such as a BiPAP (bilevel positive airway pressure).
- the capnograph may be used to detect IE state and thus aid in the control of oxygen flow Fo2(t) and total flow Fi(t) (e.g. providing oxygen flow only during inspiration as shown).
- Fig. 14 shows a capnograph with an extrapolated PrCO2 plot, depicting an alternative method of determining dilution.
- the shape of the initial curve 150 is extrapolated to give curve 154.
- the system could potentially pause the delivery of flow (both from the device and the oxygen) and take several breath waveforms without the effect of the device in any way. These breaths could be used to monitor the progression of the disease without any device effect as well as analyze the effect of the HFNT settings on the patient parameters (e.g. impact of total flow on respiratory rate of patient, or how the slopes of the capnograph are affected by HFNT.)
- the insight is fundamental to understand how HFNT is behaving and how it could be controlled to achieve optimal settings.
Landscapes
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Otolaryngology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
L'invention concerne un système de thérapie ayant une interface patient canule nasale configurée pour administrer du gaz à une cavité nasale d'un patient et un système d'administration pour administrer un gaz respiratoire enrichi en oxygène, comprenant de l'air et de l'oxygène d'enrichissement, à l'interface patient. Un capteur permet de mesurer ou d'estimer la pression partielle artérielle de CO2, PaCO2, permettant ainsi de générer des données de capnographie. Un paramètre est déterminé à partir des données de capnographie qui est représentatif de l'élimination du CO2, et le débit total, le débit d'oxygène ou le débit d'air du gaz respiratoire délivré par le système d'administration sont ajustés de manière itérative tout en surveillant le paramètre déterminé. Une valeur du débit total, du débit d'oxygène ou du débit d'air est utilisée, qui rend maximale l'élimination du CO2 ou atteint un niveau souhaité d'élimination du CO2.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263333269P | 2022-04-21 | 2022-04-21 | |
| US63/333,269 | 2022-04-21 | ||
| EP22171395.1A EP4265289A1 (fr) | 2022-04-21 | 2022-05-03 | Système et procédé de thérapie nasale à haut débit |
| EP22171395.1 | 2022-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023202908A1 true WO2023202908A1 (fr) | 2023-10-26 |
Family
ID=86185293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2023/059371 WO2023202908A1 (fr) | 2022-04-21 | 2023-04-11 | Système et méthode de thérapie nasale à haut débit |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2023202908A1 (fr) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110257550A1 (en) | 2010-03-20 | 2011-10-20 | Jay Choi | Method and Apparatus for Continuous Monitoring of Exhaled Carbon Dioxide |
| US20180104426A1 (en) * | 2015-03-31 | 2018-04-19 | Fisher & Paykel Healthcare Limited | Methods and apparatus for oxygenation and/or co2 removal |
| US20180126110A1 (en) * | 2015-02-18 | 2018-05-10 | Fisher & Paykel Healthcare Limited | Flow therapy system |
| CN111991663A (zh) * | 2020-09-14 | 2020-11-27 | 江西安联医疗器械有限公司 | 一种自动提供氧气治疗方案的3联智能系统 |
| US20200383606A1 (en) * | 2014-09-04 | 2020-12-10 | Fisher & Paykel Healthcare Limited | Exhaled gas measurement compensation during high flow respiratory therapy |
| WO2021101780A1 (fr) * | 2019-11-18 | 2021-05-27 | Incoba, Llc | Procédé et système de capnographie |
| AU2021203928A1 (en) * | 2014-10-28 | 2021-07-08 | Fisher & Paykel Healthcare Limited | Patient specific auto-flowrate control |
| US20220105288A1 (en) * | 2020-10-05 | 2022-04-07 | Zoll Medical Corporation | Respiratory distress management apparatus, system and method |
-
2023
- 2023-04-11 WO PCT/EP2023/059371 patent/WO2023202908A1/fr unknown
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110257550A1 (en) | 2010-03-20 | 2011-10-20 | Jay Choi | Method and Apparatus for Continuous Monitoring of Exhaled Carbon Dioxide |
| US20200383606A1 (en) * | 2014-09-04 | 2020-12-10 | Fisher & Paykel Healthcare Limited | Exhaled gas measurement compensation during high flow respiratory therapy |
| AU2021203928A1 (en) * | 2014-10-28 | 2021-07-08 | Fisher & Paykel Healthcare Limited | Patient specific auto-flowrate control |
| US20180126110A1 (en) * | 2015-02-18 | 2018-05-10 | Fisher & Paykel Healthcare Limited | Flow therapy system |
| US20180104426A1 (en) * | 2015-03-31 | 2018-04-19 | Fisher & Paykel Healthcare Limited | Methods and apparatus for oxygenation and/or co2 removal |
| WO2021101780A1 (fr) * | 2019-11-18 | 2021-05-27 | Incoba, Llc | Procédé et système de capnographie |
| CN111991663A (zh) * | 2020-09-14 | 2020-11-27 | 江西安联医疗器械有限公司 | 一种自动提供氧气治疗方案的3联智能系统 |
| US20220105288A1 (en) * | 2020-10-05 | 2022-04-07 | Zoll Medical Corporation | Respiratory distress management apparatus, system and method |
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