WO2023197881A1

WO2023197881A1 - Nanotube capable of promoting selective nerve self-repair

Info

Publication number: WO2023197881A1
Application number: PCT/CN2023/085035
Authority: WO
Inventors: 孙建军; 孙贺冉; 马千权; 吴超; 杨辰龙; 尹晓亮; 刘丽; 田文平; 娄晓辉; 谢聃; 杨军
Original assignee: 北京大学第三医院（北京大学第三临床医学院）
Priority date: 2022-04-14
Filing date: 2023-03-30
Publication date: 2023-10-19
Also published as: CN114917406A; CN114917406B

Abstract

The present invention relates to a nanotube capable of promoting selective nerve self-repair. The nanotube comprises a hollow nanotube body and a slidable cover plate. The side wall of the nanotube body is provided with a side wall opening part. The inside of the nanotube body is provided with a hollow cavity which is configured for inclusively receiving a nerve structure that is not completely broken and/or an exposed nerve that is not sheltered by the neurolemma. The slidable cover plate is arranged on one side of the side wall opening part, and the other side of the side wall opening part is provided with a cover plate lock catch. The slidable cover plate can be slidably switched between a first position and a second position. When the slidable cover plate is at the first position, the slidable cover plate opens the side wall opening part; when the slidable cover plate is at the second position, the slidable cover plate is engaged with the cover plate lock catch, such that the cover plate lock catch buckles the slidable cover plate and the slidable cover plate closes the side wall opening part.

Description

A nanotube that promotes self-selective neural repair

Cross-references to related applications

This application claims the rights and interests of Chinese application number 202210391655.0 submitted on April 14, 2022. The application number 202210391655.0 is hereby incorporated by reference in its entirety.

Technical field

The invention relates to the technical field of medical supplies and consumables, and in particular to a nanotube that can promote self-selective nerve repair.

Background technique

For patients with multiple or huge cysts in the sacral canal, whether it is the nerves inside the cyst or around the cyst, after long-term compression, the nerve function is on the verge of collapse, and some nerves lose their proper cylindrical shape and fuse with the cyst wall. Membranous. Any slight micromanipulation harassment may cause loss of neurological function or disorder, and the result is disabling. The clinical consequences are unexpected postoperative sensory dysfunction and even bowel dysfunction.

With the development of upright walking human civilization and the accelerated pace of urbanization, long-term sitting, standing and walking working postures have become increasingly normalized, and the incidence of sacral cysts and sacral lesions is increasing year by year. Many patients will face potential nerve damage within the sacral canal, as well as accompanying occult neurological dysfunction, or bowel and bladder dysfunction. Treatments for this kind of unspeakable hiddenness are increasingly in urgent need of society. Improving this type of neurological dysfunction can bring huge potential social benefits, and the market potential is also broad.

In the prior art, the Chinese invention patent with publication number CN101766836A discloses a method for preparing nanosilver spinal cord and peripheral nerve repair materials, using tissue engineering methods to repair human or animal spinal cord and peripheral nerve injuries. The repair material is made of collagen (types I, III, and IV) mixed with chitosan and nanosilver, and is characterized by being closed at both ends.

The Chinese invention patent with publication number CN106188583A discloses a sericin conductive hydrogel, its preparation method and a scaffold prepared therefrom. The sericin conductive hydrogel is cross-linked by sericin protein and can be injected or The minimally invasive method of transplantation into the body minimizes the trauma and pain caused by the transplantation surgery, and does not produce a serious immune response after implantation in the body.

However, most of these technical solutions in the existing technology are based on an alternative continuous nerve repair model, which is aimed at the loss or rupture of a certain segment of the nerve. Nanosilver or hydrogel connects the two broken ends of the nerve, and then the nanoparticles are used to repair the nerve. Silver or hydrogel forms a nerve-like structure and is expected to function as nerve conduction. It is a repair of a compensatory nature.

This application is based on the nerve structure that is not completely broken, but the nerve has been damaged and cannot function as a normal nerve conduction function. It plays a real role in repair and repair.

Contents of the invention

The present invention aims to provide a nanotube that can promote self-selective nerve repair. The technical problem to be solved is how to assist the self-repair of damaged nerves.

The purpose of the present invention is to solve the deficiencies of the prior art and provide a nanotube that can promote self-selective nerve repair, including a hollow nanotube body and a sliding cover. The side wall of the nanotube body is provided with a side plate. The side wall opening extends along the length direction of the nanotube body; a hollow cavity is provided inside the nanotube body, and the hollow cavity is used to inclusively accommodate incomplete Broken nerve structures and/or exposed nerves without nerve sheaths; the slidable cover is provided on one side of the side wall opening; and a cover is provided on the other side of the side wall opening. Lock; the sliding cover can slide and switch between the first position and the second position; when the sliding cover is in the first position, the sliding cover moves the side The wall opening is open; when the slidable cover is in the second position, the slidable cover is engaged with the cover lock, and the cover lock locks the slidable cover The cover is locked, and the slidable cover closes the side wall opening.

The nanotube body has a long cylindrical shape and a partially open structure.

The length of the nanotube body can be extended.

The length of the nanotube body is 2cm, 4cm or 6cm, and the inner diameter of the nanotube body is 2mm, 4mm, 6mm or 8mm. Nanotube bodies with different inner diameters are suitable for accommodating different numbers of damaged nerves.

Preferably, the interior of the nanotube body is pre-paved with a slow-release nerve regeneration stimulating factor.

Preferably, the nanotubes capable of promoting self-selective nerve repair can self-degrade within 3 years.

Further preferably, the width of the side wall opening provided on the nanotube body with an inner diameter of 4 mm is 1.5 mm; the width of the side wall opening provided on the nanotube body with an inner diameter of 6 mm is 2.5 mm; and the width of the side wall opening provided on the nanotube body with an inner diameter of 8 mm The width of the side wall opening provided on the body is 3.5mm.

Preferably, the nanotubes capable of promoting self-selective nerve repair are made of chitosan nanomaterials.

Preferably, the wall thickness of the nanotube body is 1 mm.

Preferably, the cover locks are provided every 1.9 cm along the length direction of the nanotube body, and the number of cover locks provided on nanotube bodies with different lengths varies.

beneficial effects

Compared with the prior art, the beneficial effects of the present invention are:

(1) The nanotubes of the present invention that can promote self-selective nerve repair are open but can be closed and locked in one direction;

(2) The nanotubes of the present invention that can promote self-selective nerve repair can accommodate damaged nerves;

(3) The nanotubes of the present invention can promote the self-selection of damaged nerves to repair their missing neural structures and functions;

(4) The nanotube capable of promoting self-selective nerve repair described in the present invention is not a substitute material for damaged nerves, but a protective device that assists the self-repair of damaged nerves.

Description of the drawings

The drawings are used to provide a further understanding of the technical solution of the present invention, and constitute a part of the description. They are used to explain the technical solution of the present invention together with the specific embodiments of the present application, and do not constitute a limitation of the technical solution of the present invention.

Figure 1 is a schematic diagram of the appearance of the nanotube capable of promoting self-selective nerve repair according to the present invention when placed horizontally.

Figure 2 is a cross-sectional view of a nanotube capable of promoting self-selective nerve repair according to the present invention.

Figure 3 is a schematic diagram of the appearance of the nanotube capable of promoting self-selective nerve repair according to the present invention when placed vertically.

Figure 4 is a cross-sectional view of another embodiment of a nanotube capable of promoting self-selective nerve repair according to the present invention.

Detailed ways

The invention is described in more detail below to facilitate understanding of the invention.

As shown in Figures 1 to 3, the nanotube capable of promoting self-selective nerve repair according to the present invention includes a hollow nanotube body 1 and a sliding cover 2. The side wall of the nanotube body 1 is provided with The side wall opening 5 extends along the length direction of the nanotube body 1; a hollow cavity is provided inside the nanotube body 1, and the hollow cavity is used to contain to accommodate There is no completely broken nerve structure and/or no nerve sheath covering the exposed nerve; the slidable cover 2 is provided on one side of the side wall opening 5; the other side of the side wall opening 5 A cover lock 6 is provided on the side; the slidable cover 2 can slide and switch between the first position and the second position; when the slidable cover 2 is in the first position, the The sliding cover 2 opens the side wall opening 5; when the slidable cover 2 is in the second position, the slidable cover 2 is engaged with the cover lock 6, whereby The cover lock 6 locks the slidable cover 2, and the slidable cover 2 closes the side wall opening 5.

The nanotube of the present invention that can promote self-selective nerve repair is a semi-closed nanotube that can incorporate nerves during surgery. The nerves are exposed nerves without nerve sheaths, or are Nerves that have been damaged or membranous degeneration. The above-mentioned nerves are placed in the nanotubes in groups, and the unidirectional locking nanotubes are adjusted after placement to promote degradation after nerve repair. The nanotube is suitable for environments with fluid accumulation, and root sleeve reconstruction and reinforcement molding surgeries can be performed outside the nanotube.

The nanotube body 1 is a long cylindrical, partially open basic structure. The length of the nanotube body 1 can be extended or set to different lengths and diameters (2mm, 4mm, 6mm), which is suitable for different numbers of nerve roots and damaged nerves in the cyst. The nanotubes can be pre-paved with slow-release nerve regeneration stimulating factors. , the nanotubes can self-degrade within 3 years.

Both the top 3 and the bottom 4 of the nanotube body 1 are hollow openings. Because the nerve is along this tube (i.e., the nanotube body 1), the nerve is continuous. The nanotube contains the damaged nerve part. The proximal end of the nerve starts from the end of the dura mater, and the distal end of the nerve needs to continue to travel to the distal periphery. target organ.

The nanotube thin wall of the nanotube body 1 forms a long cylindrical structure, which can be in the shape of two fans (the first fan cylinder 11 and the second fan cylinder 12 as shown in Figure 4), and the opening is usually in an unlocked state. . The two fan cylinders (the first fan cylinder 11 and the second fan cylinder 12) on opposite sides of the side wall opening 5 may partially overlap (for example, overlap within the range of A1 to A2 as shown in Figure 4) to ensure that the nanometer The tubes are open rather than scattered.

When the nanotube capable of promoting self-selective nerve repair is in an open state, the overlapping portions of the first fan cylinder 11 and the second fan cylinder 12 are connected by limiting hinge strips to ensure and limit the side. The width of the wall opening 5 is 1.5mm, 2.5mm, and 3.5mm, corresponding to different diameters (4mm, 6mm, and 8mm) respectively.

Preferably, the material of the nanotubes that can promote self-selective nerve repair is chitosan, but other nanotube base materials are not excluded.

Preferably, the wall thickness of the nanotube body 1 is limited to about 1 mm.

When the nanotubes of the present invention that can promote self-selective nerve repair are used, nanotubes with different length specifications are selected according to the size of the cyst and the length of the damaged nerve to ensure that there is no nerve sheath. The damaged nerves of the membrane are contained in the open nanotube body 1; the thickness of the nanotubes is selected according to the thickness and quantity of the damaged nerves to ensure that the damaged nerves are placed in a loose state within the open nanotube body; damaged or After the entire length of the diseased nerve is contained within the open nanotube body, liquid or powdered nerve regeneration stimulating factors for delayed degradation can be sprayed directly; the nanotube body contains the lesion after neurotrophic treatment Nerve, check again to confirm that the entire length of the damaged nerve is within the opened nanotube body, and there is no squeeze or crowding. Use a specific instrument arm to pull and close the nanotube; the opening edge part of the side wall opening 5 is provided with Cover lock 6; after pulling the nanotube to close, lock the cover lock to ensure that the nanotube is no longer open.

Preferably, the cover plate locks 6 are set every 1.9cm along the length direction of the nanotube body 1, and the number of the cover plate locks 6 provided on the nanotube bodies with different lengths varies. , the 2cm long nanotube body is provided with 2 cover locks, the 4cm long nanotube body is provided with 3 cover locks, and the 6cm long nanotube body is provided with 4 cover locks.

Once locked, the cover lock 6 cannot be opened again unless external damage or degradation occurs.

The preset degradation life of the nanotubes capable of promoting self-selective nerve repair according to the present invention is 3 years.

In a specific implementation case, the hospital received a 48-year-old female patient with sacral cyst. After sitting, standing, and walking for a long time, her sacrococcygeal perineum was tingling and numb for 10 years, which worsened for 1 year. She had frequent urination for half a year, and was incontinent. January. Preoperative images and intraoperative microscopy confirmed that the maximum diameter of the cyst was 4.2cm, containing 3 damaged nerves, and the 3 nerves merged into a bundle with a total diameter of approximately 6.5mm. Select a bundle of damaged nerves and place it in an open nanotube with a length of 4cm and a diameter of 8mm. Then spray the nerve regeneration stimulating factor to ensure that the nerves are in a relaxed state. Use a specific instrument to close the nanotube and lock the three covers. Die button. Root sleeve reconstruction and artificial dura mater reinforcement were then performed. The patient's perineal numbness persisted after surgery, along with difficulty in defecation. Three months after the operation, the numb area gradually developed a sense of electric current surge and perianal muscle beating. One year after the operation, the numbness of the perineum and difficulty in defecation gradually improved. Three years later, the perineum felt as normal and the bowel movements were normal.

The nanotube capable of promoting self-selective nerve repair described in the present invention is an inclusive, open and closable self-selective nerve repair nanotube, which can promote the self-selective repair of sacral nerves and not only facilitates the self-selection of sacral canal nerves. Sexual repair, and can contain and protect nerves.

The preferred embodiments of the present invention have been described above, but they are not intended to limit the present invention. Those skilled in the art may make modifications and changes to the embodiments disclosed herein without departing from the scope and spirit of the invention.

Claims

A nanotube that can promote self-selective nerve repair, characterized in that the nanotube that can promote self-selective nerve repair includes a hollow nanotube body and a sliding cover. The side walls of the nanotube body A side wall opening is provided on the nanotube body, and the side wall opening extends along the length direction of the nanotube body; a hollow cavity is provided inside the nanotube body, and the hollow cavity is used for containment. to accommodate nerve structures that are not completely broken and/or nerves that are exposed without nerve sheaths; the slidable cover is provided on one side of the side wall opening; and on the other side of the side wall opening A cover lock is provided; the slidable cover can slide and switch between the first position and the second position; when the slidable cover is in the first position, the slidable cover will The side wall opening is open; when the slidable cover is in the second position, the slidable cover is engaged with the cover lock, and the cover lock locks the The sliding cover plate is fastened, and the sliding cover plate closes the opening of the side wall.
The nanotube capable of promoting self-selective nerve repair according to claim 1, characterized in that the nanotube body has a long cylindrical and partially open structure.
The nanotube capable of promoting self-selective nerve repair according to claim 1, wherein the length of the nanotube body is extendable.
The nanotube capable of promoting self-selective nerve repair according to claim 1, characterized in that the length of the nanotube body is 2cm, 4cm or 6cm, and the inner diameter of the nanotube body is 2mm, 4mm, 6mm or 8mm, nanotube bodies with different inner diameters are suitable for accommodating different numbers of damaged nerves.
The nanotube capable of promoting self-selective nerve repair according to claim 1, characterized in that the interior of the nanotube body is pre-paved with a slow-release nerve regeneration stimulating factor.
The nanotube capable of promoting self-selective nerve repair according to claim 1, characterized in that the nanotube capable of promoting self-selective nerve repair can self-degrade within 3 years.
The nanotube capable of promoting self-selective nerve repair according to claim 4, characterized in that the width of the side wall opening provided on the nanotube body with an inner diameter of 4 mm is 1.5 mm; the width of the side wall opening provided on the nanotube body with an inner diameter of 6 mm The width of the side wall opening is 2.5 mm; the width of the side wall opening provided on the nanotube body with an inner diameter of 8 mm is 3.5 mm.
The nanotube capable of promoting self-selective nerve repair according to claim 1, characterized in that the nanotube capable of promoting self-selective nerve repair is made of chitosan nanomaterial.
The nanotube capable of promoting self-selective nerve repair according to claim 1, wherein the wall thickness of the nanotube body is 1 mm.
The nanotube capable of promoting self-selective nerve repair according to claim 1, characterized in that the cover locks are set every 1.9cm along the length of the nanotube body, with different lengths. The number of cover plate locks provided on the nanotube body varies.