WO2023190849A1 - Liquid composition for oral use - Google Patents

Liquid composition for oral use Download PDF

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Publication number
WO2023190849A1
WO2023190849A1 PCT/JP2023/013143 JP2023013143W WO2023190849A1 WO 2023190849 A1 WO2023190849 A1 WO 2023190849A1 JP 2023013143 W JP2023013143 W JP 2023013143W WO 2023190849 A1 WO2023190849 A1 WO 2023190849A1
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WIPO (PCT)
Prior art keywords
water
aluminum
liquid oral
oral composition
soluble
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PCT/JP2023/013143
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French (fr)
Japanese (ja)
Inventor
拓也 田淵
琢也 土屋
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第一三共ヘルスケア株式会社
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Publication of WO2023190849A1 publication Critical patent/WO2023190849A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a liquid oral composition.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 11-269073
  • Patent Document 2 Japanese Patent Application Laid-Open No. 2021-91654.
  • Patent Document 1 states that copper chlorophyllin is a compound obtained by replacing the magnesium atom in the molecule of chlorophyllin with a copper atom, and that chlorophyllin is effective as a medicine for preventing bad breath and treating wounds. It is stated that it has traditionally been incorporated into many products (paragraph 0002). The document also describes a preparation containing a copper chlorophyllin salt and an acid (Claim 1), and a method for adding an acid to prevent the tongue from being colored by the copper chlorophyllin salt (Claim 7). Are listed.
  • Example 1 The same document also describes that the degree of tongue coloring was observed for granules containing copper chlorophyllin potassium and citric acid (Example 1) and chewable tablets containing copper chlorophyllin potassium and citric acid. (Example 2, Table 1, etc.).
  • Patent Document 2 states that water-soluble polyvalent metal salts such as copper salts are medicinal ingredients that can be incorporated into dentifrice compositions, and that such ingredients can suppress hypersensitivity, suppress bad breath, and tighten gums. etc., and is described as being effective in preventing or suppressing oral diseases (paragraph 0002).
  • a water-soluble polyvalent metal salt such as copper salts
  • a water-soluble polyvalent metal salt is described as a technology for a dentifrice composition containing a water-soluble polyvalent metal salt, which is easy to put on a toothbrush, has excellent moldability, and has excellent dischargeability from a storage container even after storage.
  • a dentifrice composition containing one or more water-soluble polyvalent metal salts selected from aluminum salts, water-soluble copper salts, and water-soluble zinc salts, xanthan gum, and a cationic polymer compound is described (Claim 1). .
  • the present inventors have found that when a water-soluble copper salt such as copper gluconate is blended into a liquid oral composition, discoloration may occur in the oral cavity, for example, on the tongue, oral mucosa, or teeth. .
  • the present invention provides a technique for suppressing coloring in the oral cavity when applying a liquid oral composition containing a water-soluble copper salt.
  • the present inventors have intensively investigated the cause of coloration when using a liquid oral composition containing a water-soluble copper salt.
  • one of the causes was found to be a reaction between the water-soluble copper salt in the liquid oral composition and components present in the oral cavity.
  • the present inventors conducted further studies to suppress the coloring caused by the water-soluble copper salt in the liquid oral composition and the components present in the oral cavity, and found that water-soluble aluminum was added to the liquid oral composition.
  • the present invention was completed based on the new discovery that incorporating salt is effective.
  • the following liquid oral cavity composition and method for suppressing tooth discoloration are provided.
  • the water-soluble copper salt is one or more selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin.
  • Composition [3] The liquid oral composition according to [1] or [2], wherein the water-soluble copper salt is copper gluconate.
  • the water-soluble aluminum salt is an aluminum salt of an organic acid.
  • the water-soluble aluminum salt is one or more selected from the group consisting of aluminum lactate, potassium aluminum sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride, aluminum benzoate, and aluminum allantoin chlorohydroxy.
  • [1 The liquid oral composition according to any one of ] to [3].
  • [6] The liquid oral composition according to any one of [1] to [5], wherein the water-soluble aluminum salt is aluminum lactate.
  • the liquid oral composition according to any one of [1] to [6] which contains copper gluconate and aluminum lactate.
  • the content of the copper gluconate is 0.01% by mass or more and 0.2% by mass or less based on the entire liquid oral composition
  • the content of the water-soluble aluminum salt to the content of the water-soluble copper salt in the liquid oral composition is 0.25 or more and 300 or less in mass ratio, [1] to [8] Liquid oral composition according to any one of the above.
  • a dentifrice containing a water-soluble copper salt and a water-soluble aluminum salt can also be provided.
  • composition may contain each component alone or in combination of two or more.
  • ⁇ indicating a numerical range represents the above or below, and includes both ends of the numerical value.
  • the composition is applied intraorally, and specifically is a liquid oral composition.
  • the liquid oral composition contains a water-soluble copper salt and a water-soluble aluminum salt. Each component will be explained below.
  • the water-soluble copper salt refers to a water-soluble one among an inorganic acid salt of copper and an organic acid salt of copper.
  • the water-soluble copper salt may be either anhydrous or hydrated.
  • the water-soluble copper salt may be one used, for example, as a raw material for pharmaceuticals, foods, and cosmetics.
  • a water-soluble copper salt from the viewpoint of improving the effect of combined use with a water-soluble aluminum salt, for example, one or two selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin. The above can be mentioned.
  • the water-soluble copper salt preferably contains at least one of copper gluconate and copper sulfate, and more preferably copper gluconate.
  • the water-soluble copper salt for example, commercially available products can be used.
  • the content of the water-soluble copper salt in the liquid oral composition is preferably 0.001 mass based on the entire liquid oral composition from the viewpoint of further improving the blending effect of the water-soluble copper salt such as the halitosis suppressing effect. % or more, more preferably 0.01% by mass or more, still more preferably 0.03% by mass or more, even more preferably 0.08% by mass or more.
  • the content of the water-soluble copper salt in the liquid oral composition is preferably 10% by mass or less, more preferably The content is 1% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, even more preferably 0.2% by mass or less.
  • the content of the water-soluble copper salt in the liquid oral composition is preferably 0.001% by mass as the copper content from the viewpoint of further improving the blending effect of the water-soluble copper salt such as the halitosis suppressing effect.
  • the content is more than 0.01% by mass, and more preferably 0.01% by mass or more.
  • the content of water-soluble copper salt in the liquid oral composition is preferably 0.06% by mass or less, more preferably 0.06% by mass or less, as the amount of copper blended. It is .03% by mass or less.
  • the water-soluble aluminum salt refers to a water-soluble one among inorganic acid salts of aluminum and organic acid salts of aluminum.
  • the water-soluble aluminum salt may be either anhydrous or hydrated. Any water-soluble aluminum salt may be used as long as it is used, for example, as a raw material for pharmaceuticals, foods, and cosmetics.
  • the water-soluble aluminum salt is preferably aluminum lactate, aluminum potassium sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride (for example, aluminum chloride hexahydrate), benzoic acid. It is one or more selected from the group consisting of aluminum and allantoin chlorohydroxyaluminum, and more preferably at least one selected from the group consisting of aluminum lactate and aluminum chloride.
  • the water-soluble aluminum salt is preferably an aluminum salt of an organic acid.
  • the aluminum salt of an organic acid is, for example, one or more selected from the group consisting of aluminum lactate, aluminum citrate, and aluminum benzoate, and preferably aluminum lactate.
  • the content of the water-soluble aluminum salt in the liquid oral composition is preferably 0.01% by mass or more, more preferably The content is 0.03% by mass or more, more preferably 0.06% by mass or more, even more preferably 0.08% by mass or more, even more preferably 0.1% by mass or more.
  • the content of the water-soluble aluminum salt in the liquid oral composition is preferably 5% by mass or less based on the entire liquid oral composition. , more preferably 3.5% by mass or less, still more preferably 3% by mass or less, even more preferably 1.5% by mass or less.
  • the content of water-soluble aluminum salt in the liquid oral composition is preferably 0.002% by mass or more, more preferably 0.002% by mass or more, based on the aluminum content, from the viewpoint of improving the effect of suppressing coloring in the oral cavity. It is .005% by mass or more. Further, from the viewpoint of improving the effect of suppressing coloring in the oral cavity and suppressing the metallic taste, the content of the water-soluble aluminum salt in the liquid oral composition may be, for example, 1% by mass or less as the amount of aluminum blended, Preferably it is 0.5% by mass or less, more preferably 0.2% by mass or less.
  • the content of water-soluble aluminum salt (water-soluble aluminum salt/water-soluble copper salt) with respect to the content of water-soluble copper salt in the liquid oral composition is determined by mass ratio, from the viewpoint of improving the effect of suppressing coloring in the oral cavity. Therefore, it is preferably 0.25 or more, more preferably 0.5 or more. Further, from the viewpoint of suppressing metallic taste, the mass ratio (water-soluble aluminum salt/water-soluble copper salt) is preferably 300 or less, more preferably 100 or less, and even more preferably 50 or less.
  • the liquid oral cavity composition preferably contains copper gluconate and aluminum lactate from the viewpoint of more stably suppressing intraoral coloration.
  • the content of copper gluconate is preferably 0.01% by mass or more and 0.2% by mass or less based on the entire liquid oral composition
  • the content of aluminum lactate is preferably 0.01% by mass or more and 0.2% by mass or less with respect to the entire liquid oral composition. It is preferably 0.01% by mass or more and 3% by mass or less based on the whole.
  • Liquid oral compositions specifically include water.
  • the content of water in the liquid oral composition can be, for example, the remainder after removing components other than water in the liquid oral composition.
  • the content of water in the liquid oral composition is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more, based on the entire liquid oral composition. It is also preferably 99.99% by mass or less, more preferably 99.989% by mass or less, still more preferably 99.90% by mass or less.
  • compositions such as liquid oral compositions may contain components other than the above-mentioned components as long as the effects of the present invention are not impaired.
  • Such components include, for example, medicinal ingredients, abrasives, binders, thickeners, surfactants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, and detergents. agents, adsorbents, etc., and can be appropriately selected depending on the dosage form and the like. Specific examples of additive components are shown below, but the components that can be blended are not limited to these.
  • Examples of medicinal ingredients include one or two selected from the group consisting of bactericidal agents, anti-inflammatory agents, blood circulation promoters, tartar deposition inhibitors, stain removers, hypersensitivity inhibitors, vitamins, and plaque-degrading enzymes. The above can be mentioned. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals and the like.
  • the bactericidal agent is selected from the group consisting of, for example, isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroylsarcosine, and triclosan.
  • isopropylmethylphenol cetylpyridinium chloride
  • benzalkonium chloride benzethonium chloride
  • hinokitiol chlorhexidine hydrochloride
  • alkyldiaminoethylglycine hydrochloride sodium lauroylsarcosine
  • triclosan One or more types may be mentioned.
  • anti-inflammatory agents examples include ⁇ -glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, tranexamic acid, and ⁇ -aminocaprone.
  • Examples include one or more selected from the group consisting of acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterin, dihydrocholesterol, and lysozyme hydrochloride.
  • blood circulation promoters examples include sodium chloride.
  • tartar deposition inhibitors include zeolite, disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, and phosphoric acid.
  • examples include one or more selected from the group consisting of sodium hydrogen hydrate, disodium hydrogen phosphate (crystal), trisodium phosphate, and sodium polyphosphate.
  • stain remover examples include Macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000). etc.), sodium polyphosphate, and polyvinylpyrrolidone.
  • hypersensitivity suppressant examples include at least one selected from the group consisting of potassium nitrate and aluminum salts other than water-soluble aluminum salts.
  • vitamin preparations include ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, pyridoxine hydrochloride, DL- ⁇ -tocopherol acetate, tocopherol acetate, dl- ⁇ -tocopherol nicotinate, and tocopherol nicotine.
  • acid esters One or more types selected from the group consisting of acid esters can be mentioned.
  • dental plaque decomposing enzyme is dextranase.
  • abrasives examples include silica-based abrasives such as silicic anhydride, silica (crystalline silica or amorphous silica), silica gel, and aluminosilicate; zeolite, calcium hydrogen phosphate anhydrate, and calcium hydrogen phosphate dihydrate. selected from the group consisting of calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, quaternary calcium phosphate, and synthetic resin-based abrasives. One or more types may be mentioned.
  • binders include pullulan, gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, polyvinyl Examples include one or more selected from the group consisting of organic binders such as pyrrolidone and carboxyvinyl polymers, thickening silicic anhydride, and bentonite.
  • organic binders such as pyrrolidone and carboxyvinyl polymers, thickening silicic anhydride, and bentonite.
  • the thickening agent may be one that is commercially available as a raw material for pharmaceuticals, foods, and cosmetics, such as polyhydric alcohols, more specifically sorbitol, glycerin, concentrated glycerin, ethylene glycol, propylene glycol, 1,3 - One or more selected from the group consisting of butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylit, maltit, lactit, trehalose, sodium hyaluronate, and hydrolyzed collagen. It will be done.
  • polyhydric alcohols more specifically sorbitol, glycerin, concentrated glycerin, ethylene glycol, propylene glycol, 1,3 - One or more selected from the group consisting of butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylit, maltit, lac
  • surfactant examples include anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants, and preferably anionic surfactants, nonionic surfactants, and amphoteric surfactants.
  • anionic surfactants cationic surfactants, nonionic surfactants, and amphoteric surfactants.
  • anionic surfactants, nonionic surfactants, and amphoteric surfactants One or more selected from the group consisting of:
  • Anionic surfactants include, for example, N-acylamino acid salts, ⁇ -olefin sulfonates, N-acyl sulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters.
  • N-acylamino acid salts e.g., N-acylamino acid salts
  • ⁇ -olefin sulfonates e.g., N-acyl sulfonates
  • alkyl sulfates e.g., sodium lauryl sulfate
  • sulfates of glycerin fatty acid esters e.g., sodium lauryl sulfate
  • nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and One or more types selected from the group consisting of glycerin fatty acid esters can be mentioned.
  • amphoteric surfactants include one or more selected from the group consisting of alkyl betaine surfactants, amine oxide surfactants, and imidazolinium betaine surfactants. Specific examples thereof include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and coconut oil fatty acid amide alkyl betaine.
  • flavoring agents include monosodium L-glutamate, saccharin, sodium saccharin, disodium glycyrrhizinate, trisodium glycyrrhizinate, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, xylitol, inositol, D-sorbitol.
  • D-mannitol arabitol, raffinose, lactulose, lactitol, erythritol, reduced palatinose, palatinose, palatinite, acesulfame K, maltose, maltosyltrehalose or maltitol, neohesperidin dihydrochalcone, perillartin, p-methoxycinnamic aldehyde and thaumatin
  • preservatives include benzoates such as sodium benzoate; paraoxybenzoic acid esters such as methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol and ethanol; Examples include one or more selected from the group consisting of sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, and alkyldiaminoethylglycine hydrochloride.
  • Examples of the flavor include one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavor, and peppermint oil.
  • colorants include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red malt pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina blue pigment, coumarind pigment; A type selected from the group consisting of legal pigments such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1; riboflavin, and titanium dioxide. Or two or more types can be mentioned.
  • pH adjusting agents include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, sodium acetate hydroxide, potassium hydroxide, A group consisting of acids, alkalis, and buffers such as sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate.
  • buffers such as sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate.
  • solvent examples include, in addition to the water mentioned above, lower alcohols such as ethanol and propanol.
  • a solubilizer may be added to promote the dissolution of the above additives and medicinal ingredients in water.
  • solubilizers include polyhydric alcohols such as propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol.
  • Examples of the base include sodium hydrogen carbonate.
  • cleaning agent examples include sodium polyphosphate.
  • Examples of the adsorbent include ⁇ -cyclodextrin.
  • components suitable for use in oral compositions such as liquid oral compositions can also be appropriately blended within a range that does not impair the content of the present invention.
  • liquid oral composition is specifically a liquid preparation.
  • Liquid formulations are specifically oral formulations.
  • Specific embodiments of the liquid oral composition include one selected from the group consisting of mouthwashes, liquid toothpastes, and mouth fresheners. From the viewpoint of further improving the blending effect of the water-soluble copper salt and the water-soluble aluminum salt, the liquid oral composition is preferably a mouthwash.
  • the liquid oral composition includes a step of blending, for example, a water-soluble copper salt, a water-soluble aluminum salt, water, and other components as appropriate.
  • liquid oral composition obtained in this embodiment contains a water-soluble copper salt and a water-soluble aluminum salt, it effectively suppresses coloring when applied to the oral cavity, for example, to the tongue, oral mucosa, or teeth. can do.
  • the liquid oral composition obtained in this embodiment is suitably used as, for example, a tongue coloring inhibitor, an oral mucosa coloring inhibitor, or a tooth coloring inhibitor.
  • the method for inhibiting tongue discoloration, the method for inhibiting oral mucosa discoloration, and the method for inhibiting tooth discoloration all include applying a composition containing a water-soluble copper salt and a water-soluble aluminum salt to the oral cavity.

Abstract

Provided is a liquid composition for oral use, which contains a water-soluble copper salt and a water-soluble aluminum salt.

Description

液体口腔用組成物liquid oral composition
　本発明は、液体口腔用組成物に関する。 The present invention relates to a liquid oral composition.
　口腔用の製剤に銅化合物を配合する技術として、特許文献１（特開平１１－２６９０７３号公報）および特許文献２（特開２０２１－９１６５４号公報）に記載のものがある。 As a technique for blending a copper compound into a preparation for the oral cavity, there are those described in Patent Document 1 (Japanese Patent Application Laid-Open No. 11-269073) and Patent Document 2 (Japanese Patent Application Laid-Open No. 2021-91654).
　特許文献１には、銅クロロフィリンとはクロロフィリンの分子中にあるマグネシウム原子を銅原子に置き換えることにより得られる化合物であること、および、クロロフィリンは、医薬品としては口臭予防や創傷治療に効果的で、従来から多くの製品に配合されてきたことが記載されている（段落０００２）。そして、同文献には、銅クロロフィリンの塩及び酸を含有してなる製剤（請求項１）、ならびに、酸を添加して銅クロロフィリンの塩による舌の着色を防止する方法（請求項７）について記載されている。また、同文献には、銅クロロフィリンカリウム及びクエン酸を配合した顆粒剤（実施例１）、ならびに、銅クロロフィリンカリウム及びクエン酸を配合したチュアブル錠について、舌の着色の度合いを観察したことが記載されている（実施例２、表１等）。 Patent Document 1 states that copper chlorophyllin is a compound obtained by replacing the magnesium atom in the molecule of chlorophyllin with a copper atom, and that chlorophyllin is effective as a medicine for preventing bad breath and treating wounds. It is stated that it has traditionally been incorporated into many products (paragraph 0002). The document also describes a preparation containing a copper chlorophyllin salt and an acid (Claim 1), and a method for adding an acid to prevent the tongue from being colored by the copper chlorophyllin salt (Claim 7). Are listed. The same document also describes that the degree of tongue coloring was observed for granules containing copper chlorophyllin potassium and citric acid (Example 1) and chewable tablets containing copper chlorophyllin potassium and citric acid. (Example 2, Table 1, etc.).
　特許文献２には、銅塩等の水溶性多価金属塩は、歯磨剤組成物に配合可能な薬効成分であること、および、かかる成分により知覚過敏抑制効果や口臭抑制効果、歯茎のひきしめ効果等を有し、口腔疾患予防又は抑制に有効であることが記載されている（段落０００２）。同文献には、水溶性多価金属塩が配合され、歯ブラシに載せ易く成形性に優れ、かつ保存後も収容容器からの排出性に優れる歯磨剤組成物に関する技術として（段落０００１）、水溶性アルミニウム塩、水溶性銅塩及び水溶性亜鉛塩から選ばれる１種以上の水溶性多価金属塩、キサンタンガム及びカチオン性高分子化合物を含有する歯磨剤組成物について記載されている（請求項１）。 Patent Document 2 states that water-soluble polyvalent metal salts such as copper salts are medicinal ingredients that can be incorporated into dentifrice compositions, and that such ingredients can suppress hypersensitivity, suppress bad breath, and tighten gums. etc., and is described as being effective in preventing or suppressing oral diseases (paragraph 0002). In the same document, as a technology for a dentifrice composition containing a water-soluble polyvalent metal salt, which is easy to put on a toothbrush, has excellent moldability, and has excellent dischargeability from a storage container even after storage (Paragraph 0001), a water-soluble polyvalent metal salt is described. A dentifrice composition containing one or more water-soluble polyvalent metal salts selected from aluminum salts, water-soluble copper salts, and water-soluble zinc salts, xanthan gum, and a cationic polymer compound is described (Claim 1). .
特開平１１－２６９０７３号公報Japanese Patent Application Publication No. 11-269073 特開２０２１－９１６５４号公報JP2021-91654A
　一方、本発明者らは、液体口腔用組成物中にグルコン酸銅等の水溶性銅塩を配合すると、口腔内に、たとえば舌、口腔粘膜または歯に着色が生じる場合があることを見出した。 On the other hand, the present inventors have found that when a water-soluble copper salt such as copper gluconate is blended into a liquid oral composition, discoloration may occur in the oral cavity, for example, on the tongue, oral mucosa, or teeth. .
　そこで、本発明は、水溶性銅塩が含まれる液体口腔用組成物を適用する際の口腔内の着色を抑制する技術を提供する。 Therefore, the present invention provides a technique for suppressing coloring in the oral cavity when applying a liquid oral composition containing a water-soluble copper salt.
　本発明者らは、水溶性銅塩が含まれる液体口腔用組成物を使用した際の着色の原因を鋭意検討した。その結果、液体口腔用組成物中の水溶性銅塩と口腔内に存在する成分との反応が原因の一つとして見出された。たとえば、水溶性銅塩と、お茶に含まれるポリフェノール（たとえばタンニン酸）とが共存すると褐色の沈澱を生じることがあることが明らかになった。 The present inventors have intensively investigated the cause of coloration when using a liquid oral composition containing a water-soluble copper salt. As a result, one of the causes was found to be a reaction between the water-soluble copper salt in the liquid oral composition and components present in the oral cavity. For example, it has been revealed that the coexistence of water-soluble copper salts and polyphenols (such as tannic acid) contained in tea can result in brown precipitates.
　そこで、本発明者らは、液体口腔用組成物中の水溶性銅塩と口腔内に存在する成分とによる着色を抑制すべくさらに検討を進めたところ、液体口腔用組成物中に水溶性アルミニウム塩を配合することが効果的であることを新たに見出し、本発明を完成させた。 Therefore, the present inventors conducted further studies to suppress the coloring caused by the water-soluble copper salt in the liquid oral composition and the components present in the oral cavity, and found that water-soluble aluminum was added to the liquid oral composition. The present invention was completed based on the new discovery that incorporating salt is effective.
　本発明によれば、以下の液体口腔用組成物および歯着色抑制方法が提供される。
［１］　水溶性銅塩と水溶性アルミニウム塩とを含有する液体口腔用組成物。
［２］　前記水溶性銅塩が、グルコン酸銅、硫酸銅、クエン酸銅、銅クロロフィルおよび銅クロロフィリンナトリウムからなる群から選ばれる一種または二種以上である、［１］に記載の液体口腔用組成物。
［３］　前記水溶性銅塩がグルコン酸銅である、［１］または［２］に記載の液体口腔用組成物。
［４］　前記水溶性アルミニウム塩が、有機酸のアルミニウム塩である、［１］乃至［３］いずれか一つに記載の液体口腔用組成物。
［５］　前記水溶性アルミニウム塩が、乳酸アルミニウム、硫酸アルミニウムカリウム、硫酸アルミニウム、硝酸アルミニウム、塩化アルミニウム、安息香酸アルミニウムおよびアラントインクロルヒドロキシアルミニウムからなる群から選ばれる一種または二種以上である、［１］乃至［３］いずれか一つに記載の液体口腔用組成物。
［６］　前記水溶性アルミニウム塩が乳酸アルミニウムである、［１］乃至［５］いずれか一つに記載の液体口腔用組成物。
［７］　グルコン酸銅と乳酸アルミニウムとを含有する、［１］乃至［６］いずれか一つに記載の液体口腔用組成物。
［８］　前記グルコン酸銅の含有量が、当該液体口腔用組成物全体に対して０．０１質量％以上０．２質量％以下であり、
　前記乳酸アルミニウムの含有量が、当該液体口腔用組成物全体に対して０．０１質量％以上３質量％以下である、［７］に記載の液体口腔用組成物。
［９］　当該液体口腔用組成物中の前記水溶性銅塩の含有量に対する前記水溶性アルミニウム塩の含有量が、質量比で、０．２５以上３００以下である、［１］乃至［８］いずれか一つに記載の液体口腔用組成物。
［１０］　舌着色抑制剤である、［１］乃至［９］いずれか一つに記載の液体口腔用組成物。
［１１］　口腔粘膜着色抑制剤である、［１］乃至［９］いずれか一つに記載の液体口腔用組成物。
［１２］　洗口液である、［１］乃至［１１］いずれか一つに記載の液体口腔用組成物。
［１３］　水溶性銅塩および水溶性アルミニウム塩を含む組成物を口腔に適用することを含む、歯着色抑制方法。 According to the present invention, the following liquid oral cavity composition and method for suppressing tooth discoloration are provided.
[1] A liquid oral composition containing a water-soluble copper salt and a water-soluble aluminum salt.
[2] The liquid for oral cavity according to [1], wherein the water-soluble copper salt is one or more selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin. Composition.
[3] The liquid oral composition according to [1] or [2], wherein the water-soluble copper salt is copper gluconate.
[4] The liquid oral composition according to any one of [1] to [3], wherein the water-soluble aluminum salt is an aluminum salt of an organic acid.
[5] The water-soluble aluminum salt is one or more selected from the group consisting of aluminum lactate, potassium aluminum sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride, aluminum benzoate, and aluminum allantoin chlorohydroxy. [1 The liquid oral composition according to any one of ] to [3].
[6] The liquid oral composition according to any one of [1] to [5], wherein the water-soluble aluminum salt is aluminum lactate.
[7] The liquid oral composition according to any one of [1] to [6], which contains copper gluconate and aluminum lactate.
[8] The content of the copper gluconate is 0.01% by mass or more and 0.2% by mass or less based on the entire liquid oral composition,
The liquid oral composition according to [7], wherein the content of the aluminum lactate is 0.01% by mass or more and 3% by mass or less based on the entire liquid oral composition.
[9] The content of the water-soluble aluminum salt to the content of the water-soluble copper salt in the liquid oral composition is 0.25 or more and 300 or less in mass ratio, [1] to [8] Liquid oral composition according to any one of the above.
[10] The liquid oral composition according to any one of [1] to [9], which is a tongue coloring inhibitor.
[11] The liquid oral composition according to any one of [1] to [9], which is an oral mucosa coloring inhibitor.
[12] The liquid oral composition according to any one of [1] to [11], which is a mouthwash.
[13] A method for inhibiting tooth discoloration, comprising applying to the oral cavity a composition containing a water-soluble copper salt and a water-soluble aluminum salt.
　なお、これらの各構成の任意の組み合わせや、本発明の表現を方法、装置などの間で変換したものもまた本発明の態様として有効である。
　たとえば、本発明によれば、水溶性銅塩と水溶性アルミニウム塩とを含有する歯磨剤を提供することもできる。 Note that arbitrary combinations of these configurations and expressions of the present invention converted between methods, devices, etc. are also effective as aspects of the present invention.
For example, according to the present invention, a dentifrice containing a water-soluble copper salt and a water-soluble aluminum salt can also be provided.
　本発明によれば、水溶性銅塩が含まれる液体口腔用組成物を適用する際の口腔内の着色を抑制することができる。 According to the present invention, it is possible to suppress discoloration in the oral cavity when applying a liquid oral composition containing a water-soluble copper salt.
　以下、本発明の実施形態について説明する。本実施形態において、組成物は、各成分をいずれも単独でまたは２種以上を組み合わせて含むことができる。
　本明細書において、数値範囲を示す「～」は、以上、以下を表し、両端の数値をいずれも含む。 Embodiments of the present invention will be described below. In this embodiment, the composition may contain each component alone or in combination of two or more.
In this specification, "~" indicating a numerical range represents the above or below, and includes both ends of the numerical value.
　本実施形態において、組成物は口腔内に適用されるものであり、具体的には液体口腔用組成物である。 In this embodiment, the composition is applied intraorally, and specifically is a liquid oral composition.
　（液体口腔用組成物）
　本実施形態において、液体口腔用組成物は、水溶性銅塩と水溶性アルミニウム塩とを含有する。
　以下、各成分について説明する。 (Liquid oral composition)
In this embodiment, the liquid oral composition contains a water-soluble copper salt and a water-soluble aluminum salt.
Each component will be explained below.
（水溶性銅塩）
　水溶性銅塩は、具体的には、銅の無機酸塩や銅の有機酸塩のうち、水溶性のものをいう。水溶性銅塩は、無水物および水和物のいずれであってもよい。水溶性銅塩は、たとえば医薬品・食品・化粧品原料に用いられるものであればよい。
　また、水溶性銅塩として、水溶性アルミニウム塩との併用効果向上の観点から、たとえば、グルコン酸銅、硫酸銅、クエン酸銅、銅クロロフィルおよび銅クロロフィリンナトリウムからなる群から選ばれる一種または二種以上が挙げられる。口臭抑制効果等の水溶性銅塩の配合効果をより向上する観点から、水溶性銅塩は好ましくはグルコン酸銅および硫酸銅の少なくとも一方を含み、より好ましくはグルコン酸銅である。
　水溶性銅塩としては、たとえば市販品を用いることができる。 (Water-soluble copper salt)
Specifically, the water-soluble copper salt refers to a water-soluble one among an inorganic acid salt of copper and an organic acid salt of copper. The water-soluble copper salt may be either anhydrous or hydrated. The water-soluble copper salt may be one used, for example, as a raw material for pharmaceuticals, foods, and cosmetics.
In addition, as a water-soluble copper salt, from the viewpoint of improving the effect of combined use with a water-soluble aluminum salt, for example, one or two selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin. The above can be mentioned. From the viewpoint of further improving the mixing effect of the water-soluble copper salt, such as the halitosis suppressing effect, the water-soluble copper salt preferably contains at least one of copper gluconate and copper sulfate, and more preferably copper gluconate.
As the water-soluble copper salt, for example, commercially available products can be used.
　液体口腔用組成物中の水溶性銅塩の含有量は、口臭抑制効果等の水溶性銅塩の配合効果をより向上する観点から、液体口腔用組成物全体に対し、好ましくは０．００１質量％以上であり、より好ましくは０．０１質量％以上、さらに好ましくは０．０３質量％以上、より好ましくは０．０８質量％以上である。
　また、口腔内の着色抑制効果向上の観点から、液体口腔用組成物中の水溶性銅塩の含有量は、液体口腔用組成物全体に対し、好ましくは１０質量％以下であり、より好ましくは１質量％以下、さらに好ましくは０．５質量％以下、さらにより好ましくは０．３質量％以下、よりいっそう好ましくは０．２質量％以下である。 The content of the water-soluble copper salt in the liquid oral composition is preferably 0.001 mass based on the entire liquid oral composition from the viewpoint of further improving the blending effect of the water-soluble copper salt such as the halitosis suppressing effect. % or more, more preferably 0.01% by mass or more, still more preferably 0.03% by mass or more, even more preferably 0.08% by mass or more.
In addition, from the viewpoint of improving the effect of suppressing coloring in the oral cavity, the content of the water-soluble copper salt in the liquid oral composition is preferably 10% by mass or less, more preferably The content is 1% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, even more preferably 0.2% by mass or less.
　また、液体口腔用組成物中の水溶性銅塩の含有量は、口臭抑制効果等の水溶性銅塩の配合効果をより向上する観点から、銅の配合量として、好ましくは０．００１質量％以上であり、より好ましくは０．０１質量％以上である。
　また、口腔内の着色抑制効果向上の観点から、液体口腔用組成物中の水溶性銅塩の含有量は、銅の配合量として、好ましくは０．０６質量％以下であり、より好ましくは０．０３質量％以下である。 In addition, the content of the water-soluble copper salt in the liquid oral composition is preferably 0.001% by mass as the copper content from the viewpoint of further improving the blending effect of the water-soluble copper salt such as the halitosis suppressing effect. The content is more than 0.01% by mass, and more preferably 0.01% by mass or more.
In addition, from the viewpoint of improving the effect of suppressing coloring in the oral cavity, the content of water-soluble copper salt in the liquid oral composition is preferably 0.06% by mass or less, more preferably 0.06% by mass or less, as the amount of copper blended. It is .03% by mass or less.
（水溶性アルミニウム塩）
　水溶性アルミニウム塩は、具体的には、アルミニウムの無機酸塩やアルミニウムの有機酸塩のうち、水溶性のものをいう。水溶性アルミニウム塩は、無水物および水和物のいずれであってもよい。水溶性アルミニウム塩は、たとえば医薬品・食品・化粧品原料に用いられるものであればよい。 (Water-soluble aluminum salt)
Specifically, the water-soluble aluminum salt refers to a water-soluble one among inorganic acid salts of aluminum and organic acid salts of aluminum. The water-soluble aluminum salt may be either anhydrous or hydrated. Any water-soluble aluminum salt may be used as long as it is used, for example, as a raw material for pharmaceuticals, foods, and cosmetics.
　口腔内の着色をより安定的に抑制する観点から、水溶性アルミニウム塩は、好ましくは、乳酸アルミニウム、硫酸アルミニウムカリウム、硫酸アルミニウム、硝酸アルミニウム、塩化アルミニウム（たとえば塩化アルミニウム六水和物）、安息香酸アルミニウムおよびアラントインクロルヒドロキシアルミニウムからなる群から選ばれる一種または二種以上であり、より好ましくは乳酸アルミニウムおよび塩化アルミニウムからなる群から選ばれる少なくとも一種である。 From the viewpoint of more stably suppressing intraoral coloration, the water-soluble aluminum salt is preferably aluminum lactate, aluminum potassium sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride (for example, aluminum chloride hexahydrate), benzoic acid. It is one or more selected from the group consisting of aluminum and allantoin chlorohydroxyaluminum, and more preferably at least one selected from the group consisting of aluminum lactate and aluminum chloride.
　口腔内の着色をより安定的に抑制する観点から、水溶性アルミニウム塩は、好ましくは有機酸のアルミニウム塩である。
　同様の観点から、有機酸のアルミニウム塩は、たとえば、乳酸アルミニウム、クエン酸アルミニウムおよび安息香酸アルミニウムからなる群から選ばれる一種または二種以上であり、好ましくは乳酸アルミニウムである。 From the viewpoint of more stably suppressing coloring in the oral cavity, the water-soluble aluminum salt is preferably an aluminum salt of an organic acid.
From the same viewpoint, the aluminum salt of an organic acid is, for example, one or more selected from the group consisting of aluminum lactate, aluminum citrate, and aluminum benzoate, and preferably aluminum lactate.
　液体口腔用組成物中の水溶性アルミニウム塩の含有量は、口腔内の着色抑制効果向上の観点から、液体口腔用組成物全体に対し、好ましくは０．０１質量％以上であり、より好ましくは０．０３質量％以上、さらに好ましくは０．０６質量％以上、さらにより好ましくは０．０８質量％以上、よりいっそう好ましくは０．１質量％以上である。
　また、口腔内の着色抑制効果向上および金属味抑制の観点から、液体口腔用組成物中の水溶性アルミニウム塩の含有量は、液体口腔用組成物全体に対し、好ましくは５質量％以下であり、より好ましくは３．５質量％以下、さらに好ましくは３質量％以下、さらにより好ましくは１．５質量％以下である。 The content of the water-soluble aluminum salt in the liquid oral composition is preferably 0.01% by mass or more, more preferably The content is 0.03% by mass or more, more preferably 0.06% by mass or more, even more preferably 0.08% by mass or more, even more preferably 0.1% by mass or more.
In addition, from the viewpoint of improving the effect of suppressing coloring in the oral cavity and suppressing the metallic taste, the content of the water-soluble aluminum salt in the liquid oral composition is preferably 5% by mass or less based on the entire liquid oral composition. , more preferably 3.5% by mass or less, still more preferably 3% by mass or less, even more preferably 1.5% by mass or less.
　また、液体口腔用組成物中の水溶性アルミニウム塩の含有量は、口腔内の着色抑制効果向上の観点から、アルミニウムの配合量として、好ましくは０．００２質量％以上であり、より好ましくは０．００５質量％以上である。
　また、口腔内の着色抑制効果向上および金属味抑制の観点から、液体口腔用組成物中の水溶性アルミニウム塩の含有量は、アルミニウムの配合量として、たとえば１質量％以下であってもよく、好ましくは０．５質量％以下であり、より好ましくは０．２質量％以下である。 In addition, the content of water-soluble aluminum salt in the liquid oral composition is preferably 0.002% by mass or more, more preferably 0.002% by mass or more, based on the aluminum content, from the viewpoint of improving the effect of suppressing coloring in the oral cavity. It is .005% by mass or more.
Further, from the viewpoint of improving the effect of suppressing coloring in the oral cavity and suppressing the metallic taste, the content of the water-soluble aluminum salt in the liquid oral composition may be, for example, 1% by mass or less as the amount of aluminum blended, Preferably it is 0.5% by mass or less, more preferably 0.2% by mass or less.
　また、液体口腔用組成物中の水溶性銅塩の含有量に対する水溶性アルミニウム塩の含有量（水溶性アルミニウム塩／水溶性銅塩）は、質量比で、口腔内の着色抑制効果向上の観点から、好ましくは０．２５以上であり、より好ましくは０．５以上である。
　また、金属味抑制の観点から、上記質量比（水溶性アルミニウム塩／水溶性銅塩）は、好ましくは３００以下であり、より好ましくは１００以下、さらに好ましくは５０以下である。 In addition, the content of water-soluble aluminum salt (water-soluble aluminum salt/water-soluble copper salt) with respect to the content of water-soluble copper salt in the liquid oral composition is determined by mass ratio, from the viewpoint of improving the effect of suppressing coloring in the oral cavity. Therefore, it is preferably 0.25 or more, more preferably 0.5 or more.
Further, from the viewpoint of suppressing metallic taste, the mass ratio (water-soluble aluminum salt/water-soluble copper salt) is preferably 300 or less, more preferably 100 or less, and even more preferably 50 or less.
　本実施形態において、液体口腔用組成物は、口腔内の着色をより安定的に抑制する観点から、好ましくはグルコン酸銅と乳酸アルミニウムとを含有する。
　このとき、グルコン酸銅の含有量は、液体口腔用組成物全体に対して、好ましくは０．０１質量％以上０．２質量％以下であり、乳酸アルミニウムの含有量は、液体口腔用組成物全体に対して好ましくは０．０１質量％以上３質量％以下である。 In this embodiment, the liquid oral cavity composition preferably contains copper gluconate and aluminum lactate from the viewpoint of more stably suppressing intraoral coloration.
At this time, the content of copper gluconate is preferably 0.01% by mass or more and 0.2% by mass or less based on the entire liquid oral composition, and the content of aluminum lactate is preferably 0.01% by mass or more and 0.2% by mass or less with respect to the entire liquid oral composition. It is preferably 0.01% by mass or more and 3% by mass or less based on the whole.
（水）
　液体口腔用組成物は、具体的には水を含む。
　液体口腔用組成物中の水の含有量は、たとえば液体口腔用組成物中の水以外の成分を除いた残部とすることができる。
　また、液体口腔用組成物中の水の含有量は、液体口腔用組成物全体に対して、好ましくは５０質量％以上であり、より好ましくは６０質量％以上、さらに好ましくは７０質量％以上であり、また、好ましくは９９．９９質量％以下であり、より好ましくは９９．９８９質量％以下、さらに好ましくは９９．９０質量％以下である。 (water)
Liquid oral compositions specifically include water.
The content of water in the liquid oral composition can be, for example, the remainder after removing components other than water in the liquid oral composition.
Further, the content of water in the liquid oral composition is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more, based on the entire liquid oral composition. It is also preferably 99.99% by mass or less, more preferably 99.989% by mass or less, still more preferably 99.90% by mass or less.
（その他成分）
　液体口腔用組成物等の組成物は、本発明の効果を損なわない範囲で、上述の成分以外の成分を含んでもよい。
　かかる成分としては、たとえば、薬用成分、研磨剤、粘結剤、粘稠剤、界面活性剤、矯味剤、防腐剤、香料、着色剤、ｐＨ調整剤、溶剤、可溶化剤、基剤、洗浄剤、吸着剤等が挙げられ、剤形等に応じて適宜選択し得る。以下に添加成分の具体例を示すが、配合可能な成分はこれらに限定されるものではない。 (Other ingredients)
Compositions such as liquid oral compositions may contain components other than the above-mentioned components as long as the effects of the present invention are not impaired.
Such components include, for example, medicinal ingredients, abrasives, binders, thickeners, surfactants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, and detergents. agents, adsorbents, etc., and can be appropriately selected depending on the dosage form and the like. Specific examples of additive components are shown below, but the components that can be blended are not limited to these.
　薬用成分としては、たとえば、殺菌剤、抗炎症剤、血行促進剤、歯石沈着抑制剤、ステイン除去剤、知覚過敏抑制剤、ビタミン剤および歯垢分解酵素からなる群から選択される一種または二種以上が挙げられる。これらの薬効成分は、医薬品等に使用しうるものであれば限定されない。 Examples of medicinal ingredients include one or two selected from the group consisting of bactericidal agents, anti-inflammatory agents, blood circulation promoters, tartar deposition inhibitors, stain removers, hypersensitivity inhibitors, vitamins, and plaque-degrading enzymes. The above can be mentioned. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals and the like.
　薬用成分のうち、殺菌剤としては、たとえば、イソプロピルメチルフェノール、塩化セチルピリジニウム、塩化ベンザルコニウム、塩化ベンゼトニウム、ヒノキチオール、クロルヘキシジン塩酸塩、塩酸アルキルジアミノエチルグリシン、ラウロイルサルコシンナトリウムおよびトリクロサンからなる群から選択される一種または二種以上が挙げられる。 Among medicinal ingredients, the bactericidal agent is selected from the group consisting of, for example, isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroylsarcosine, and triclosan. One or more types may be mentioned.
　抗炎症剤としては、たとえば、β－グリチルレチン酸、グリチルレチン酸、グリチルリチン酸、グリチルリチン酸二アンモニウム、グリチルリチン酸二ナトリウム、グリチルリチン酸三ナトリウム、グリチルリチン酸二カリウム、グリチルリチン酸モノアンモニウム、トラネキサム酸、ε－アミノカプロン酸、アズレンスルホン酸ナトリウム水和物、アラントイン、アラントインジヒドロキシアルミニウム、エピジヒドロコレステリン、ジヒドロコレステロールおよびリゾチーム塩酸塩からなる群から選択される一種または二種以上が挙げられる。 Examples of anti-inflammatory agents include β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, tranexamic acid, and ε-aminocaprone. Examples include one or more selected from the group consisting of acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterin, dihydrocholesterol, and lysozyme hydrochloride.
　血行促進剤としては、たとえば、塩化ナトリウムが挙げられる。 Examples of blood circulation promoters include sodium chloride.
　歯石沈着抑制剤としては、たとえば、ゼオライト、リン酸水素二ナトリウム、ピロリン酸二水素二ナトリウム、ピロリン酸ナトリウム、無水ピロリン酸ナトリウム、ピロリン酸四ナトリウム（無水）、リン酸一水素二ナトリウム、リン酸水素ナトリウム水和物、リン酸水素二ナトリウム（結晶）、リン酸三ナトリウムおよびポリリン酸ナトリウムからなる群から選択される一種または二種以上が挙げられる。 Examples of tartar deposition inhibitors include zeolite, disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, and phosphoric acid. Examples include one or more selected from the group consisting of sodium hydrogen hydrate, disodium hydrogen phosphate (crystal), trisodium phosphate, and sodium polyphosphate.
　ステイン除去剤としては、たとえば、マクロゴール（マクロゴール２００、マクロゴール３００、マクロゴール４００、マクロゴール６００、マクロゴール１０００、マクロゴール１５００、マクロゴール１５４０、マクロゴール４０００、マクロゴール６０００、マクロゴール２００００など）、ポリリン酸ナトリウムおよびポリビニルピロリドンからなる群から選択される一種または二種以上が挙げられる。 Examples of the stain remover include Macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000). etc.), sodium polyphosphate, and polyvinylpyrrolidone.
　知覚過敏抑制剤としては、たとえば、硝酸カリウムおよび水溶性アルミニウム塩以外のアルミニウム塩からなる群から選択される少なくとも一種が挙げられる。 Examples of the hypersensitivity suppressant include at least one selected from the group consisting of potassium nitrate and aluminum salts other than water-soluble aluminum salts.
　ビタミン剤としては、たとえば、アスコルビン酸、Ｌ－アスコルビン酸、アスコルビン酸ナトリウム、Ｌ－アスコルビン酸ナトリウム、ピリドキシン塩酸塩、酢酸ＤＬ－α－トコフェロール、トコフェロール酢酸エステル、ニコチン酸ｄｌ－α－トコフェロールおよびトコフェロールニコチン酸エステルからなる群から選択される一種または二種以上が挙げられる。 Examples of vitamin preparations include ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, pyridoxine hydrochloride, DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotine. One or more types selected from the group consisting of acid esters can be mentioned.
　歯垢分解酵素としては、たとえばデキストラナーゼが挙げられる。 An example of a dental plaque decomposing enzyme is dextranase.
　研磨剤としては、たとえば、無水ケイ酸、シリカ（結晶性シリカ又は非晶性シリカ）、シリカゲル、アルミノシリケート等のシリカ系研磨剤；ゼオライト、リン酸水素カルシウム無水和物、リン酸水素カルシウム２水和物、ピロリン酸カルシウム、炭酸カルシウム、水酸化アルミニウム、アルミナ、炭酸マグネシウム、第３リン酸マグネシウム、ケイ酸ジルコニウム、第３リン酸カルシウム、ハイドロキシアパタイト、第４リン酸カルシウムおよび合成樹脂系研磨剤からなる群から選択される一種または二種以上が挙げられる。 Examples of abrasives include silica-based abrasives such as silicic anhydride, silica (crystalline silica or amorphous silica), silica gel, and aluminosilicate; zeolite, calcium hydrogen phosphate anhydrate, and calcium hydrogen phosphate dihydrate. selected from the group consisting of calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, quaternary calcium phosphate, and synthetic resin-based abrasives. One or more types may be mentioned.
　粘結剤としては、たとえば、プルラン、ゼラチン、メチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロースナトリウム、カラギーナン、アルギン酸ナトリウム、キサンタンガム、ポリアクリル酸ナトリウム、アラビアガム、グアーガム、ローカストビーンガム、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー等の有機系粘結剤、増粘性無水ケイ酸およびベントナイトからなる群から選択される一種または二種以上が挙げられる。 Examples of binders include pullulan, gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, polyvinyl Examples include one or more selected from the group consisting of organic binders such as pyrrolidone and carboxyvinyl polymers, thickening silicic anhydride, and bentonite.
　粘稠剤としては、たとえば医薬品・食品・化粧品原料として市販されているものであればよく、たとえば、多価アルコール、さらに具体的にソルビット、グリセリン、濃グリセリン、エチレングリコール、プロピレングリコール、１，３－ブチレングリコール、プロパンジオール（１，３－プロパンジオール）、ポリエチレングリコール、ポリプロピレングリコール、キシリット、マルチット、ラクチット、トレハロース、ヒアルロン酸ナトリウムおよび加水分解コラーゲンからなる群から選択される一種または二種以上が挙げられる。 The thickening agent may be one that is commercially available as a raw material for pharmaceuticals, foods, and cosmetics, such as polyhydric alcohols, more specifically sorbitol, glycerin, concentrated glycerin, ethylene glycol, propylene glycol, 1,3 - One or more selected from the group consisting of butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylit, maltit, lactit, trehalose, sodium hyaluronate, and hydrolyzed collagen. It will be done.
　界面活性剤としては、具体的には、アニオン界面活性剤、カチオン界面活性剤、ノニオン界面活性剤および両性界面活性剤が挙げられ、好ましくはアニオン界面活性剤、ノニオン界面活性剤および両性界面活性剤からなる群から選択される一種または二種以上である。 Specific examples of the surfactant include anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants, and preferably anionic surfactants, nonionic surfactants, and amphoteric surfactants. One or more selected from the group consisting of:
　アニオン界面活性剤では、たとえば、Ｎ－アシルアミノ酸塩、α－オレフィンスルホン酸塩、Ｎ－アシルスルホン酸塩、アルキル硫酸塩（たとえばラウリル硫酸ナトリウム）、および、グリセリン脂肪酸エステルの硫酸塩からなる群から選択される一種または二種以上が挙げられる。
　ノニオン界面活性剤では、たとえば、ポリオキシエチレンアルキルエーテル、ポリオキシエチレン－ポリオキシプロピレンブロック共重合体、ポリオキシエチレン硬化ヒマシ油、グリセリンエステルのポリオキシエチレンエーテル、ショ糖脂肪酸エステル、アルキロールアミドおよびグリセリン脂肪酸エステルからなる群から選択される一種または二種以上が挙げられる。
　両性界面活性剤では、たとえば、アルキルベタイン系界面活性剤、アミンオキサイド系界面活性剤およびイミダゾリニウムベタイン系界面活性剤からなる群から選択される一種または二種以上が挙げられる。その具体例としては、２－アルキル－Ｎ－カルボキシメチル－Ｎ－ヒドロキシエチルイミダゾリニウムベタインやヤシ油脂肪酸アミドアルキルベタインが挙げられる。 Anionic surfactants include, for example, N-acylamino acid salts, α-olefin sulfonates, N-acyl sulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters. One or more selected types may be mentioned.
Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and One or more types selected from the group consisting of glycerin fatty acid esters can be mentioned.
Examples of amphoteric surfactants include one or more selected from the group consisting of alkyl betaine surfactants, amine oxide surfactants, and imidazolinium betaine surfactants. Specific examples thereof include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and coconut oil fatty acid amide alkyl betaine.
　矯味剤としては、たとえば、Ｌ－グルタミン酸ナトリウム、サッカリン、サッカリンナトリウム、グリチルリチン酸二ナトリウム、グリチルリチン酸三ナトリウム、ショ糖、ブドウ糖、果糖、乳糖、ハチミツ、アスパルテーム、ステビア、スクラロース、キシリトール、イノシトール、Ｄ－ソルビトール、Ｄ－マンニトール、アラビトール、ラフィノース、ラクチュロース、ラクチトール、エリスリトール、還元パラチノース、パラチノース、パラチニット、アセスルファムＫ、マルトース、マルトシルトレハロースまたはマルチトール、ネオヘスペリジンジヒドロカルコン、ペリラルチン、ｐ－メトキシシンナミックアルデヒドおよびソーマチンからなる群から選択される一種または二種以上が挙げられる。 Examples of flavoring agents include monosodium L-glutamate, saccharin, sodium saccharin, disodium glycyrrhizinate, trisodium glycyrrhizinate, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, xylitol, inositol, D-sorbitol. , D-mannitol, arabitol, raffinose, lactulose, lactitol, erythritol, reduced palatinose, palatinose, palatinite, acesulfame K, maltose, maltosyltrehalose or maltitol, neohesperidin dihydrochalcone, perillartin, p-methoxycinnamic aldehyde and thaumatin One or more types selected from the group consisting of:
　防腐剤としては、たとえば、安息香酸ナトリウム等の安息香酸塩；メチルパラベン、エチルパラベン、ブチルパラベン、イソプロピルパラベン、プロピルパラベン、イソブチルパラベン、ベンジルパラベン等のパラオキシ安息香酸エステル；フェノキシエタノール、エタノール等のアルコール類；ソルビン酸、安息香酸、デヒドロ酢酸、プロピオン酸およびこれらの塩；エチレンジアミン四酢酸塩、ならびに、塩酸アルキルジアミノエチルグリシンからなる群から選択される一種または二種以上が挙げられる。 Examples of preservatives include benzoates such as sodium benzoate; paraoxybenzoic acid esters such as methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol and ethanol; Examples include one or more selected from the group consisting of sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, and alkyldiaminoethylglycine hydrochloride.
　香料としては、たとえば、Ｌ－メントール、ペパーミント、スペアミント、フルーツ香料およびハッカ油からなる群から選択される一種または二種以上が挙げられる。 Examples of the flavor include one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavor, and peppermint oil.
　着色剤としては、たとえば、ベニバナ赤色素、クチナシ黄色素、クチナシ青色素、シソ色素、紅麹色素、赤キャベツ色素、ニンジン色素、ハイビスカス色素、カカオ色素、スピルリナ青色素、クマリンド色素等の天然色素；赤色３号、赤色１０４号、赤色１０５号、赤色１０６号、黄色４号、黄色５号、緑色３号、青色１号等の法定色素；リボフラビン、および、二酸化チタンからなる群から選択される一種または二種以上が挙げられる。 Examples of colorants include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red malt pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina blue pigment, coumarind pigment; A type selected from the group consisting of legal pigments such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1; riboflavin, and titanium dioxide. Or two or more types can be mentioned.
　ｐＨ調整剤としては、たとえば、酢酸、塩酸、硫酸、硝酸、クエン酸、リン酸、リンゴ酸、グルコン酸、マレイン酸、コハク酸、グルタミン酸、ピロリン酸、酒石酸、酢酸水酸化ナトリウム、水酸化カリウム、酢酸ナトリウム、炭酸ナトリウム、クエン酸ナトリウム、クエン酸水素ナトリウム、リン酸、リン酸ナトリウム、リン酸一水素ナトリウム、リン酸二水素ナトリウム、リン酸二水素カリウム等の酸やアルカリ、緩衝剤からなる群から選択される一種または二種以上が挙げられる。 Examples of pH adjusting agents include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, sodium acetate hydroxide, potassium hydroxide, A group consisting of acids, alkalis, and buffers such as sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate. One or more types selected from the following may be mentioned.
　溶剤としては、上述の水の他、たとえば、エタノール、プロパノールなどの低級アルコールが挙げられる。 Examples of the solvent include, in addition to the water mentioned above, lower alcohols such as ethanol and propanol.
　可溶化剤は、水への上記添加剤や薬効成分の溶解を促進させるために添加してもよい。そのような可溶化剤の例として、プロピレングリコール、ジプロピレングリコール、ブチレングリコール、ポリエチレングリコール等の多価アルコール類が挙げられる。 A solubilizer may be added to promote the dissolution of the above additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol.
　基剤としては、たとえば炭酸水素ナトリウムが挙げられる。 Examples of the base include sodium hydrogen carbonate.
　洗浄剤としては、たとえばポリリン酸ナトリウムが挙げられる。 Examples of the cleaning agent include sodium polyphosphate.
　吸着剤としては、たとえばβ－シクロデキストリンが挙げられる。 Examples of the adsorbent include β-cyclodextrin.
　さらに、上記成分以外にも、本発明の内容を損なわない範囲で、通常、液体口腔用組成物等の口腔用組成物の用途に適した成分も適宜配合することができる。 Furthermore, in addition to the above-mentioned components, components suitable for use in oral compositions such as liquid oral compositions can also be appropriately blended within a range that does not impair the content of the present invention.
（液体製剤）
　また、液体口腔用組成物は、具体的には液体製剤である。液体製剤は、具体的には経口投与製剤である。
　液体口腔用組成物の具体的態様として、洗口液、液体歯磨および口中清涼剤からなる群から選択される一種が挙げられる。水溶性銅塩および水溶性アルミニウム塩の配合効果をより向上する観点から、液体口腔用組成物は好ましくは洗口液である。 (liquid preparation)
Moreover, the liquid oral composition is specifically a liquid preparation. Liquid formulations are specifically oral formulations.
Specific embodiments of the liquid oral composition include one selected from the group consisting of mouthwashes, liquid toothpastes, and mouth fresheners. From the viewpoint of further improving the blending effect of the water-soluble copper salt and the water-soluble aluminum salt, the liquid oral composition is preferably a mouthwash.
（製造方法）
　本実施形態において、液体口腔用組成物は、たとえば水溶性銅塩、水溶性アルミニウム塩、水および適宜その他の成分を配合する工程を含む。 (Production method)
In this embodiment, the liquid oral composition includes a step of blending, for example, a water-soluble copper salt, a water-soluble aluminum salt, water, and other components as appropriate.
　本実施形態において得られる液体口腔用組成物は、水溶性銅塩および水溶性アルミニウム塩を含むため、口腔内に適用した際の着色、たとえば舌、口腔粘膜または歯への着色を効果的に抑制することができる。 Since the liquid oral composition obtained in this embodiment contains a water-soluble copper salt and a water-soluble aluminum salt, it effectively suppresses coloring when applied to the oral cavity, for example, to the tongue, oral mucosa, or teeth. can do.
　本実施形態において得られる液体口腔用組成物は、たとえば舌着色抑制剤、口腔粘膜着色抑制剤または歯着色抑制剤として好適に用いられる。 The liquid oral composition obtained in this embodiment is suitably used as, for example, a tongue coloring inhibitor, an oral mucosa coloring inhibitor, or a tooth coloring inhibitor.
　本実施形態において、舌着色抑制方法、口腔粘膜着色抑制方法および歯着色抑制方法は、いずれも、水溶性銅塩および水溶性アルミニウム塩を含む組成物を口腔に適用することを含む。 In the present embodiment, the method for inhibiting tongue discoloration, the method for inhibiting oral mucosa discoloration, and the method for inhibiting tooth discoloration all include applying a composition containing a water-soluble copper salt and a water-soluble aluminum salt to the oral cavity.
　以上、本発明の実施形態について述べたが、これらは本発明の例示であり、上記以外の様々な構成を採用することもできる。 Although the embodiments of the present invention have been described above, these are merely examples of the present invention, and various configurations other than those described above can also be adopted.
　以下、実施例および比較例を挙げて本実施形態を具体的に説明するが、本実施形態はこれらの実施例に限定されるものではない。 Hereinafter, this embodiment will be specifically described with reference to Examples and Comparative Examples, but this embodiment is not limited to these Examples.
　（試験例）
　（実施例１～３０、比較例１～３）
　表１～表４に記載の成分を混合し、各例の洗口液を調製し、後述の方法で評価した。各表に記載の成分の詳細を以下に示す。
グルコン酸銅（ＧＣｕ）：扶桑化学工業社製
乳酸アルミニウム（乳酸Ａｌ）：富士フイルム和光純薬社製
塩化アルミニウム六水和物（塩化Ａｌ）：関東化学社製
タンニン酸：ナカライテスク社製 (Test example)
(Examples 1 to 30, Comparative Examples 1 to 3)
The components listed in Tables 1 to 4 were mixed to prepare mouthwashes for each example, and evaluated using the methods described below. Details of the components listed in each table are shown below.
Copper gluconate (GCu): manufactured by Fuso Chemical Co., Ltd. Aluminum lactate (Al lactic acid): manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. Aluminum chloride hexahydrate (Al chloride): manufactured by Kanto Kagaku Co., Ltd. Tannic acid: manufactured by Nacalai Tesque Co., Ltd.
（評価方法）
　各例で得られた洗口液に、組成物中の濃度が２ｍｇ／ｍＬとなる量のタンニン酸を添加し、３７℃で１週間静置した後、沈澱の着色の程度を、水溶性銅塩が同濃度で水溶性アルミニウム塩を含有しない比較例と比較し、目視にて評価した。評価基準を以下に示す。
＋＋：著明改善
＋：改善
±：変化なし
－：悪化 (Evaluation method)
To the mouthwash obtained in each example, tannic acid was added in an amount such that the concentration in the composition was 2 mg/mL, and after standing at 37°C for one week, the degree of coloration of the precipitate was determined by water-soluble copper. Comparison was made with a comparative example containing no water-soluble aluminum salt at the same concentration of salt, and visually evaluated. The evaluation criteria are shown below.
++: Significant improvement +: Improvement ±: No change -: Worsening
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
　表１～表４より、各実施例においては、洗口液とタンニン酸とが共存した際の着色を抑制することができた。
　また、各実施例で得られた組成物は、洗口液として通常使用できる使用感であった。 From Tables 1 to 4, in each Example, coloring could be suppressed when the mouthwash and tannic acid coexisted.
Furthermore, the compositions obtained in each example had a feel that could be used normally as a mouthwash.
　この出願は、２０２２年３月３１日に出願された日本出願特願２０２２－０５８４９１号を基礎とする優先権を主張し、その開示のすべてをここに取り込む。 This application claims priority based on Japanese Patent Application No. 2022-058491 filed on March 31, 2022, and all of its disclosure is incorporated herein.

Claims (13)

  1. 　水溶性銅塩と水溶性アルミニウム塩とを含有する液体口腔用組成物。 A liquid oral composition containing a water-soluble copper salt and a water-soluble aluminum salt.
  2. 　前記水溶性銅塩が、グルコン酸銅、硫酸銅、クエン酸銅、銅クロロフィルおよび銅クロロフィリンナトリウムからなる群から選ばれる一種または二種以上である、請求項１に記載の液体口腔用組成物。 The liquid oral composition according to claim 1, wherein the water-soluble copper salt is one or more selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin.
  3. 　前記水溶性銅塩がグルコン酸銅である、請求項１または２に記載の液体口腔用組成物。 The liquid oral composition according to claim 1 or 2, wherein the water-soluble copper salt is copper gluconate.
  4. 　前記水溶性アルミニウム塩が、有機酸のアルミニウム塩である、請求項１乃至３いずれか一項に記載の液体口腔用組成物。 The liquid oral composition according to any one of claims 1 to 3, wherein the water-soluble aluminum salt is an aluminum salt of an organic acid.
  5. 　前記水溶性アルミニウム塩が、乳酸アルミニウム、硫酸アルミニウムカリウム、硫酸アルミニウム、硝酸アルミニウム、塩化アルミニウム、安息香酸アルミニウムおよびアラントインクロルヒドロキシアルミニウムからなる群から選ばれる一種または二種以上である、請求項１乃至３いずれか一項に記載の液体口腔用組成物。 Claims 1 to 3, wherein the water-soluble aluminum salt is one or more selected from the group consisting of aluminum lactate, potassium aluminum sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride, aluminum benzoate, and aluminum allantoin chlorohydroxy. Liquid oral composition according to any one of the items.
  6. 　前記水溶性アルミニウム塩が乳酸アルミニウムである、請求項１乃至５いずれか一項に記載の液体口腔用組成物。 The liquid oral composition according to any one of claims 1 to 5, wherein the water-soluble aluminum salt is aluminum lactate.
  7. 　グルコン酸銅と乳酸アルミニウムとを含有する、請求項１乃至６いずれか一項に記載の液体口腔用組成物。 The liquid oral composition according to any one of claims 1 to 6, containing copper gluconate and aluminum lactate.
  8. 　前記グルコン酸銅の含有量が、当該液体口腔用組成物全体に対して０．０１質量％以上０．２質量％以下であり、
    　前記乳酸アルミニウムの含有量が、当該液体口腔用組成物全体に対して０．０１質量％以上３質量％以下である、請求項７に記載の液体口腔用組成物。     The content of the copper gluconate is 0.01% by mass or more and 0.2% by mass or less based on the entire liquid oral composition,
    The liquid oral composition according to claim 7, wherein the content of the aluminum lactate is 0.01% by mass or more and 3% by mass or less based on the entire liquid oral composition.
  9. 　当該液体口腔用組成物中の前記水溶性銅塩の含有量に対する前記水溶性アルミニウム塩の含有量が、質量比で、０．２５以上３００以下である、請求項１乃至８いずれか一項に記載の液体口腔用組成物。 According to any one of claims 1 to 8, the content of the water-soluble aluminum salt to the content of the water-soluble copper salt in the liquid oral composition is 0.25 or more and 300 or less in mass ratio. A liquid oral composition as described.
  10. 　舌着色抑制剤である、請求項１乃至９いずれか一項に記載の液体口腔用組成物。 The liquid oral composition according to any one of claims 1 to 9, which is a tongue staining inhibitor.
  11. 　口腔粘膜着色抑制剤である、請求項１乃至９いずれか一項に記載の液体口腔用組成物。 The liquid oral composition according to any one of claims 1 to 9, which is an oral mucosa coloring inhibitor.
  12. 　洗口液である、請求項１乃至１１いずれか一項に記載の液体口腔用組成物。 The liquid oral composition according to any one of claims 1 to 11, which is a mouthwash.
  13. 　水溶性銅塩および水溶性アルミニウム塩を含む組成物を口腔に適用することを含む、歯着色抑制方法。 A method for inhibiting tooth discoloration, comprising applying to the oral cavity a composition containing a water-soluble copper salt and a water-soluble aluminum salt.
PCT/JP2023/013143 2022-03-31 2023-03-30 Liquid composition for oral use WO2023190849A1 (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010189358A (en) * 2009-02-20 2010-09-02 Lion Corp Composition for oral cavity
WO2022131147A1 (en) * 2020-12-14 2022-06-23 ライオン株式会社 Oral cavity composition
JP2022099622A (en) * 2020-12-23 2022-07-05 小林製薬株式会社 Oral composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010189358A (en) * 2009-02-20 2010-09-02 Lion Corp Composition for oral cavity
WO2022131147A1 (en) * 2020-12-14 2022-06-23 ライオン株式会社 Oral cavity composition
JP2022099622A (en) * 2020-12-23 2022-07-05 小林製薬株式会社 Oral composition

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD MINTEL; 23 June 2021 (2021-06-23), "Toothpaste", XP093093926, Database accession no. 8810077 *
DATABASE GNPD MINTEL; December 2021 (2021-12-01), "Herbal Toothpaste for Bad Breath & Gum Disease", XP093093913, Database accession no. 9238786 *

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