WO2023187396A1

WO2023187396A1 - A composition comprising a coated aerosol-generating material and uses thereof

Info

Publication number: WO2023187396A1
Application number: PCT/GB2023/050844
Authority: WO
Inventors: Robert Press; Jeremy Campbell
Original assignee: Nicoventures Trading Limited
Priority date: 2022-04-01
Filing date: 2023-03-31
Publication date: 2023-10-05
Also published as: GB202204789D0

Abstract

The invention relates to a composition comprising an aerosol-generating material comprising a dried precursor material comprising an extract from a flavour- and/or active-containing plant material and optionally an aerosol-former material, and a moisture impermeable coating surrounding the aerosol-generating material. The compositions may be used to generate an aerosol. For example, the compositions may be used in combustible or non-combustible aerosol-provision systems. The invention also relates to aerosol-provision systems comprising the compositions, and methods of providing a composition.

Description

A composition comprising a coated aerosol-generating material and uses thereof

Field The invention relates to a composition comprising an aerosol-generating material and a moisture impermeable coating, methods of manufacturing the composition and uses thereof.

Background Aerosol-generating materials for use in a combustible or a non-combustible aerosol provision system may include a variety of different active substances and/or flavours. Factors such as the concentration of volatile active and/or flavour components in the aerosol-generating materials and the stability of the aerosol-generating materials will influence the properties of the aerosol generated.

Summary

According to a first aspect of the present invention, there is provided a composition comprising: an aerosol-generating material comprising a dried precursor material comprising an extract from a flavour- and/or active-containing plant material, and a moisture impermeable coating surrounding the aerosol-generating material.

In some embodiments, the moisture impermeable coating decomposes upon heating to allow volatile components generated by heating the aerosol-generating material to be released.

In some embodiments, the moisture impermeable coating decomposes at a temperature at or above about too°C.

In some embodiments, the moisture impermeable coating comprises one or more selected from the group consisting of: a polysaccharide or cellulosic material, or a derivative thereof; a gum; a protein material; a polyol matrix material; a wax; a wax ester; and a polymer

In some embodiments, the moisture impermeable coating completely encapsulates the aerosol-generating material. In some embodiments, the moisture impermeable coating prevents or retards absorption of moisture by the aerosol-generating material from the surrounding environment.

In some embodiments, the moisture impermeable coating has a thickness of from about i pm to about too pm.

In some embodiments, the aerosol-generating material is in the form of granules.

In some embodiments, the granules have a particle size of from about i mm to about 4 mm.

In some embodiments, the aerosol-generating material is in the form of agglomerates or tablets formed from particles.

In some embodiments, the agglomerates or tablets have a size from about 3 mm to about 20 mm. In some embodiments, discrete particles, agglomerates or tablets of the aerosolgenerating material are surrounded by the moisture impermeable coating.

In some embodiments, the coatings of different discrete particles, agglomerates or tablets of the aerosol-generating material decompose at different temperatures or at different rates to control the release of volatile components generated by heating the dried aerosol-generating material.

In some embodiments, different discrete particles or portions of the aerosol-generating material are surrounded by coatings of different thickness.

In some embodiments, different discrete particles or portions of the aerosol-generating material are surrounded by coatings of different coating materials.

In some embodiments, the aerosol-generating material comprises an aerosol-former material. In some embodiments, the precursor material comprises from about to to about 95% by weight extract from a flavour- or active-containing plant material.

In some embodiments, the precursor material comprises from about 1 to about 36 wt% aerosol-former material.

In some embodiments, the precursor material comprises from o to about 40% by weight of an excipient. In some embodiments, the aerosol-generating material comprises from about 45 to about 99% by weight dried extract from the flavour- or active-containing plant material.

In some embodiments, the aerosol-generating material comprises from about 1 to about 34% by weight aerosol-former material.

In some embodiments, the aerosol-generating material comprises from o to about 25% by weight of an excipient. In some embodiments, the plant material is selected from the group consisting of tobacco, eucalyptus, star anise, cocoa and hemp.

In some embodiments, the extract from a flavour- or active-containing plant material is an aqueous extract.

In some embodiments, the extract from a flavour- or active-containing plant material is an aqueous tobacco extract.

In some embodiments, the aerosol-generating material comprises from about 40 to about 99% by weight tobacco solids.

In some embodiments, the aerosol-generating material has a water content of no more than about 5% (calculated on a wet weight basis). In some embodiments, the composition is for use in an aerosol provision system. According to a second aspect of the present invention, there is provided an article comprising an aerosol-generating material comprising a dried precursor material comprising an extract from a flavour- and/or active-containing plant material, and a moisture impermeable coating surrounding the aerosol-generating material.

In some embodiments, the article comprises a film or wrapper comprising the moisture impermeable coating. In some embodiments, the moisture impermeable coating is deposited on a moisture permeable carrier. In some embodiments, the article comprises the composition according to the first aspect.

According to a third aspect of the present invention, there is provided a noncombustible aerosol-provision system comprising a composition according to the first aspect or an article according to the second aspect.

According to a fourth aspect, there is provided a method of providing a composition comprising diying a precursor material comprising an extract from a flavour- and/or active-containing plant material to form an aerosol-generating material and applying a moisture impermeable coating surrounding the aerosol-generating material.

In some embodiments, the precursor material is dried by spray-diying or freeze-diying.

In some embodiments, the moisture impermeable coating is applied by a fluidised bed coating process.

In some embodiments, the moisture impermeable coating is formed as part of the spray-drying or freeze-diying step. In some embodiments, the moisture impermeable coating forming material is included in the precursor material.

Brief Description of the Drawings

Embodiments of the invention will now be described, by way of example only, with reference to accompanying drawings, in which: Figure i is a side-on cross sectional view of a first embodiment of a consumable comprising a composition as described herein; and

Figure 2 is a perspective illustration of a non-combustible aerosol provision device for generating aerosol from the composition of the consumable shown in Figure 1.

Detailed Description

An aerosol-generating material is a material that is capable of generating aerosol, for example when heated, irradiated or energized in any other way. Conventional aerosol-generating materials which comprise tobacco material or a tobacco extract may be used in combustible and non-combustible aerosol-generating devices, including hybrid devices and tobacco heating products, to provide the user with an aerosol with an authentic tobacco taste and texture. One issue encountered with such materials is that the content of the flavour, other volatile compound(s) and nicotine decreases with storage of the aerosol-generating material, dropping off particularly towards the end of the life of the material. This is because the more volatile components, including nicotine and many flavours and aromas, are readily released from the material. Additionally, as the moisture content of the aerosol-generating material increases through moisture absorption, the release of substances such as nicotine and flavours is negatively impacted. Aerosol-generating materials that are produced using conventional methods and procedures commonly need to be used within one to three days of production. There is therefore a need to improve the shelf life of the aerosol-generating material. A further issue associated with conventional aerosol-generating materials comprising tobacco material or a tobacco extract is that the concentration of the desired components such as nicotine and flavours is relatively low. This limits the concentration of these desired components in the aerosol generated. Additionally, this means that a relatively large amount of the aerosol-generating material is needed and, accordingly, high amounts of energy are required to heat the aerosol-generating material in order to release the desired components.

The present invention relates to compositions comprising a dried or dehydrated aerosol-generating material formed from an extract from a flavour- and/or active- containing plant material and a moisture-impermeable coating that surrounds the dried aerosol-generating material. In some embodiments, the extract is a liquid solution or suspension and it may be dried or dehydrated using a process such as spraydrying or freeze-drying. The dried or dehydrated aerosol-generating material may be formed from a precursor material comprising the extract from a flavour- and/or activecontaining plant material and an aerosol-former material.

The aerosol-generating material comprising the dried extract from a flavour- and/or active-containing plant material comprises a high concentration of the flavour and/or active, with little or no material that does not contribute to the aerosol generated from the dried aerosol-generating material. As such, small amounts of the aerosol- generating material are sufficient to generate aerosol with desired active and flavour content. Further, the aerosol may be generated with the input of relatively low levels of energy.

An additional benefit of the aerosol-generating material being used as a solid substrate is that the low water content reduces issues associated with “hot puff’, which are known in the art.

In some embodiments, the dried aerosol-generating material has a moisture content of from o to about 10%, or from o to about 5% (calculated on a wet weight basis), as measured by gas chromatography-thermal conductivity detector (GC-TCD) or Karl Fischer titration. In some embodiments, the moisture content of the dried aerosolgenerating material is less than about 3 wt%, for example from about o to about 3 wt%, or from about 0.5 to about 2.5 wt %. Karl Fischer titration is a classic method of chemical analysis for reliably determining trace amounts of water in a sample, and it can be readily carried out using an automated Karl Fischer titrator. Similarly, the use of GC-TCD is also a well-established method for reliably determining the water content in a sample. Unless stated otherwise, references to moisture content herein are references to the moisture content as measured by Karl Fischer titration.

The dried aerosol-generating material may be hygroscopic and so measures need to be taken to ensure that the aerosol-generating material does not absorb moisture during processing, incorporation into a final product and storage in that final product prior to use. It is not usually necessary for conventional aerosol-generating materials to be protected from the moisture in the surrounding environment. This is because conventional aerosol-generating materials are not hygroscopic and not particularly sensitive to moisture. In addition, humectants such as glycerol are often included in conventional aerosol-generating materials in appropriate amounts in order to target a particular moisture level in the aerosol-generating material. The highly concentrated nature of the dried aerosol-generating material used in the present invention means that the absorption of even small amounts of moisture can be very detrimental to the properties of the aerosol-generating material and to the quality of the aerosol produced. What is more, the absorption of water can occur to such an extent that the dry powder takes on a paste-like consistency, which is undesirable in the compositions and consumables described herein. Prevention of or reduction in absorption of water by the aerosol-generating material will also help to manage or avoid the phenomenon known as “hot puff’.

In the present disclosure, a moisture-impermeable coating is provided, surrounding the aerosol-generating material. This coating is intended to prevent or reduce the exposure of the aerosol-generating material to moisture, thus preventing or reducing the absorption of moisture by the aerosol-generating material prior to its use.

Thus, compositions are provided comprising: an aerosol-generating material comprising a dried precursor material comprising an extract from a flavour- and/or active-containing plant material and an aerosol-former material, and a moisture impermeable coating surrounding the aerosol-generating material.

In some embodiments, the hygroscopic aerosol-generating material has a moisture content of no greater than about 10% or no greater than about 5% (calculated on a wet weight basis), as measured by gas chromatography-thermal conductivity detector (GC- TCD) or Karl Fischer titration. This moisture content is stable, meaning that the moisture content of the aerosol-generating material is within this range not only when it is first prepared and/or when it is surrounded with the moisture-impermeable coating, but also after incorporation into an aerosol-generating article and following transport and storage. This stable moisture content is observed despite the fact that the hygroscopic aerosol-generating material would rapidly absorb moisture if exposed to the environment, even under “normal” humidity conditions. Indeed, when the aerosolgenerating material is described as hygroscopic, this means that it will rapidly absorb water from the surrounding environment to significantly increase its water content. For example, upon exposure of the uncoated aerosol-generating material to the environment (for example, upon storage in an open container or the like), the moisture content rapidly increases to above 20% or above 25% (calculated on a wet weight basis), as measured by gas chromatography-thermal conductivity detector (GC-TCD) or Karl Fischer titration. The moisture impermeable coating

In the compositions disclosed herein, the dried aerosol-generating material is surrounded by a moisture impermeable coating. This coating creates a moisture impermeable barrier around the dried aerosol-generating material. The physical and chemical properties of the coating materials are important. In addition to forming a moisture impermeable coating, the coating also needs to remain stable and in place during the period between manufacture and use by the consumer. In some embodiments, it is desirable for the moisture impermeable coating to become permeable when the aerosol-generating material is heated to generate an aerosol. This is necessary to ensure that the aerosol can be released. In some embodiments, the coating is rendered permeable by melting or other decomposition of the coating material or at least part of the coating.

In some embodiments, the decomposition of the coating involves the coating losing its physical integrity so that it no longer forms a barrier around the aerosol-generating material. This may, for example, involve the coating melting, crumbling, disintegrating or otherwise breaking down.

Once a coating material is heated to its melting point, it can be expected that the integrity of the moisture impermeable coating may be compromised. The coating materials should therefore be selected so that the moisture impermeable coatings remain intact when exposed to normal environmental temperatures. Therefore, in some embodiments, the coating materials used should be ones that form moisture impermeable coatings that are stable at temperatures below 40 or 5O°C. In some embodiments, it may be desirable to select a coating material that will form a moisture impermeable coating that remains intact during more extreme temperatures that may be encountered during storage and transport, such as those of 60 to 8o°C.

In some embodiments, the moisture impermeable coating may become permeable when the temperature is raised to about too to no°C, so as to avoid superheating any moisture present in the coated aerosol-generating material. In some embodiments, the coating opens rapidly upon heating to form an aerosol. This will reduce the likelihood of the coating interfering with the volatilisation and the release of the resultant gas or vapour.

In some embodiments, the temperature at which the moisture impermeable coating becomes permeable, for example as a result of decomposition, is at least about 5O°C, at least about 6o°C, at least about 7O°C at least about 8o°C, at least about 9O°C, at least about too°C, at least about no°C, at least about 12O°C at least about 13O°C, at least about 14O°C, at least about 15O°C, at least about t6o°C, at least about 17O°C, at least about t8o°C, at least about 19O°C or at least about 200°C.

Additionally or alternatively, the temperature at which the moisture impermeable coating becomes permeable, for example as a result of decomposition, is no more than about 28O°C, no more than about 27O°C, no more than about 26o°C, no more than about 25O°C, no more than about 24O°C, no more than about 23O°C, no more than about 220°C, no more than about 2to°C or no more than 200°C, no more than about 19O°C, no more than about t8o°C, no more than about 17O°C, no more than about t6o°C, no more than about 15O°C, no more than about 14O°C, no more than about 13O°C, no more than about 12O°C, no more than about no°C, or no more than about too°C.

In some embodiments, the moisture impermeable coating comprises one or more materials selected from: a polysaccharide or cellulosic material, or a derivative thereof; a gum; a protein material; a polyol matrix material; a wax; a wax ester; and a polymer.ioo nm to about 50 pm. In some embodiments, the average particle size of the coating powder is at least about too nm, at least about 200 nm, at least about 300 nm, at least about 400 nm, at least about 500 nm, at least about 600 nm, at least about 700 nm, at least about 800 nm, at least about 900 nm, at least about 1 pm, at least about 2 pm, at least about 3 pm, at least about 4 pm, at least about 5 pm, at least about 10 pm, , at least about 15 jam, at least about 20 um, at least about 25 iim, at least about 30 um, at least about 35 um, or at least about 40 um.

Additionally or alternatively, the average particle size of the coating powder is no more than about 50 pm, no more than about 45 pm, no more than about 40 pm, no more than about 35 pm, no more than about 30 pm, no more than about 25 pm, no more than about 20 pm, no more than about 15 pm, no more than about 10 pm, no more than about 5 pm, no more than about 4 pm, no more than about 3 pm, no more than about 2 pm, or no more than about 1 pm.

In some embodiments, the coating adheres to the surface of the aerosol-generating material by virtue of inter-particle forces, such as Van der Waals forces. In some embodiments, the surface of the aerosol-generating material is tacky and so particles of coating material readily adhere to the surface to form a complete or substantially complete coating. The tackiness of the aerosol-generating material may be adjusted by adjusting the moisture content of the aerosol-generating material at the time when the coating is applied.

In some embodiments, the moisture impermeable coating is formed as part of the spray-drying or freeze-drying step. For example, the moisture impermeable coating forming material may be included in the precursor material and forms a coating as the precursor material is dried. This may require the aerosol-generating material and coating material to have chemical properties that ensure that the coating material migrates to the surface of the dried material so that it surrounds the dried aerosol- generating material. For example, in some embodiments, the coating material is an apolar and/or hydrophobic material that may be included in the precursor material to be dried.

As discussed above, the moisture-impermeable coating has the benefit of protecting the aerosol-generating material from moisture and the negative effects this can have in the material and the aerosol generated when it is heated. The coating can also, as mentioned control the release of the aerosol generated by heating the aerosolgenerating material. In addition, there are other benefits provided by the coatings described herein. The aerosol-generating material may be tacky or sticky. This can make the material difficult to process and handle. The coating applied to the surface of the aerosol-generating material masks this tackiness, rendering the composition more readily processed and handled. The coating may also enhance the structural integrity of the aerosol-generating material. The coating gives the particle or portions of aerosolgenerating material additional support and strength, reducing the tendency for it to break and form dust that can be detrimental to the products and machineiy used to make them.

The dried aerosol-generating material

The aerosol-generating material comprises a dried extract from a flavour- and/or active-containing plant material. In some embodiments, the aerosol-generating material further comprises an aerosol-former material.

In some embodiments, the aerosol-generating material is formed by drying a precursor material comprising an extract from a flavour- and/or active-containing plant material. The drying process is selected to retain the desired components of the precursor material and, therefore, the aerosol-generating material may comprise one or more active substances and/or flavours.

In some embodiments, the precursor material further comprises one or more aerosolformer material. Additionally or alternatively, one or more aerosol-former materials may be added to the dried precursor material to provide an aerosol-generating material with the desired aerosol-former material content.

The precursor material and/or the dried aerosol-generating material may also optionally include one or more other functional materials.

Therefore, the aerosol-generating material may comprise one or more active substances and/or flavours, and, optionally, one or more aerosol -former materials. The precursor material and/or the dried aerosol-generating material may also optionally include one or more other functional materials.

The invention enjoys the advantage of an aerosol-generating material that is formulated to have an increased shelflife and so it may be easily transported and stored. Without wishing to be bound by any particular theory, it is hypothesised that the low water content of the dried aerosol-generating material reduces evaporation over time of other solvents, and reduces degradation of nicotine and/ or other volatile compounds. A low water content also inhibits microbial growth. The compositions comprising the dried aerosol-generating materials described herein are stable at a range of temperatures and humidities and have an increased shelf-life, and are therefore easy to store and transport. In some embodiments, the compositions may be stored at temperatures in the range of o-35°C. In some embodiments, the compositions may be stored at a relative humidity of up to about 50%, prior to use and possibly as high as 90% RH.

The aerosol-generating materials also have the advantage of having a high concentration of the desired components. This means that relatively small amounts of the aerosol-generating material are required and less energy is required to heat and release the desired components. Significantly, the aerosols generated from these materials also provide an authentic tobacco taste of reasonable strength. A further advantage of the aerosol-generating materials is that they may be used as a solid aerosol-generating substrate in Hybrid systems or Tobacco Heating Products (THPs). This makes the invention versatile enough to be used in a range of products without the need for further processing. In some embodiments, the extract from a flavour- or active-substance containing plant material is an extract derived by contacting the plant material with a suitable solvent, such as an aqueous solvent or an alcohol such as ethanol. The liquid portion comprising the solvent and any dissolved plant components may then be separated or partially separated from the remaining solid plant material to provide the extract to be included in the precursor composition and dried.

In some embodiments, the extract from a flavour- or active-substance containing plant material is an extract derived from tobacco material. The tobacco extract or material may be from or may be any type of tobacco and any part of the tobacco plant, including tobacco lamina, stem, stalk, ribs, scraps and shorts or mixtures of two or more thereof. Suitable tobacco extracts or materials include the following types: Virginia or flue-cured tobacco, Burley tobacco, Oriental tobacco, or blends of tobacco materials, optionally including those listed here. The tobacco may be expanded, such as dry-ice expanded tobacco (DIET), or processed by any other means. In some embodiments, the tobacco material may be reconstituted tobacco material. The tobacco may be pre-processed or unprocessed, and may be, for instance, solid stems (SS); shredded dried stems (SDS); steam treated stems (STS); or any combination thereof. The tobacco material may be fermented, cured, uncured, toasted, or otherwise pre-treated. The tobacco material may be provided in the form of cut rag tobacco. The cut rag tobacco can have a cut width of at least 15 cuts per inch (about 5.9 cuts per cm, equivalent to a cut width of about 1.7 mm) for example. The cut rag tobacco can be formed from a mixture of forms of tobacco material, for instance a mixture of one or more of paper reconstituted tobacco, leaf tobacco, extruded tobacco and bandcast tobacco.

The precursor material which is dried to form the aerosol-generating material may comprise at least about 10 wt%, at least about 15 wt%, at least about 20 wt%, at least about 25 wt%, at least about 30 wt%, at least about 35 wt%, or at least about 40 wt% tobacco solids (calculated on a wet weight basis). Additionally or alternatively, the precursor material may comprise up to about 60 wt%, up to about 55 wt%, up to about 50 wt%, up to about 45 wt%, or up to about 40 wt% tobacco solids (calculated on a wet weight basis). In some embodiments, the precursor material comprises from about 20 wt% to about 40 wt% tobacco solids (calculated on a wet weight basis). In some embodiments, the precursor material comprises at least about 10 wt%, about 20 wt%, at least about 30 wt%, at least about 40 wt%, at least about 50 wt%, at least about 60 wt%, at least about 70 wt%, at least about 80 wt%, or at least about 90 wt% extract from a tobacco or other flavour- or active-substance containing plant material (calculated on a wet weight basis). Alternatively or additionally, precursor material may comprise up to about 99 wt%, up to about 90 wt%, up to about 80 wt%, up to about 70 wt% or up to about 60 wt% extract from tobacco or other flavour- or activesubstance containing plant material (calculated on a wet weight basis). In some embodiments, the precursor material comprises around 50 wt% tobacco extract (calculated on a wet weight basis).

In some embodiments, the aerosol-generating material may comprise at least about 45 wt%, at least about 50 wt%, at least about 60 wt%, at least about 70 wt%, at least about 80 wt%, at least about 90 wt%, or at least about 95 wt% tobacco material or tobacco extract, or flavour- or active-substance containing plant material extract (calculated on a diy weight basis). In some embodiments, the aerosol-generating material may comprise about 60 to about 80 wt% tobacco extract (calculated on a diy weight basis). In some embodiments, the dried aerosol-generating material may comprise from about 2 wt% to about to wt% of nicotine, or from about 3 to about 6 wt% of nicotine (calculated on a dry weight basis).

In some embodiments, the precursor material comprises around 50 v/v% tobacco extract. Where the precursor material comprises around 50 v/v% tobacco extract and the tobacco extract has a tobacco solid content of between about 55 and about 60 v/v%, the overall tobacco solid content of the precursor material is from about 27.5 to about 30 v/v%.

In some embodiments, the tobacco extract has a solids content of between about 40 and about 65 wt%, between about 45 and about 65 wt%, or between about 40 and about 60 wt% (calculated on a wet weight basis). In some embodiments, the water content of the tobacco extract is between about 35 wt% and about 65 wt%, or between about 35 and about 55 wt% (calculated on a wet weight basis). In some embodiments, the nicotine content of the tobacco extract is between about 1 wt% and about 5 wt% (calculated on a wet weight basis). In some embodiments, the dried aerosol-generating material may comprise at least about 45 wt%, at least about 50 wt%, at least about 60 wt%, at least about 70 wt%, at least about 80 wt%, at least about 90 wt%, or at least about 95 wt% tobacco solids (calculated on a dry weight basis). Additionally or alternatively, the aerosol-generating material may comprise up to about 99 wt%, up to about 98 wt%, up to about 95 wt%, up to about 90 wt% or up to about 80 wt%. In some embodiments, the dried aerosolgenerating material may comprise about 60 to about 80 wt% tobacco solids (calculated on a dry weight basis).

In some embodiments, the tobacco extract is an aqueous tobacco extract. In some embodiments, the tobacco extract may be concentrated and subsequently diluted before being added to the precursor material and dried. In other embodiments, the tobacco extract is not concentrated and may be used directly in the precursor material.

The precursor material may be in the form of a sluriy, a suspension, a gel, a liquid or a solid, but in some embodiments which may be preferred, it is in the form of a suspension or liquid. In some embodiments, particles of solid material may be removed from the extract and/or from the precursor material by filtration and/or centrifugation.

In some embodiments, it may be desirable for any particles in the precursor composition to have an average particle size of no greater than about 3 mm, of no greater than 1 mm, of no greater than about 0.5 mm, or to have an average particle size of no greater than about 0.3 mm, when measured by sieving or by observing the size of the particles by SEM. The water content of the precursor material may be at least about 20 wt%, at least about 30 wt%, at least about 40 wt%, at least about 50 wt%, at least about 60 wt%, at least about 70 wt%, at least about 80 wt%, or at least about 90 wt% on a wet weight basis. Alternatively or additionally, the water content of the precursor material may be up to about 95 wt%, up to about 90 wt%, up to about 85 wt%, up to about 80 wt%, up to about 75 wt%, up to about 70 wt%, up to about 65 wt%, up to about 60 wt%, up to about 55 wt% or up to about 50 wt% on a wet weight basis. In some embodiments, the water content of the precursor material is between about 40 and about 50 wt % on a wet weight basis (50% and 60 v/v%). When the precursor material has a lower water content, the spray/freeze-diying process is quicker, as there is less water to remove.

In some embodiments, the dried aerosol-generating material and/or the precursor material comprises one or more active substance. This may be derived from the extract or it may be added. In some embodiments, the extract from a flavour- or activesubstance containing plant material comprises an active substance.

The active substance may be a physiologically active material, which is a material intended to achieve or enhance a physiological response. The active substance may for example be selected from nutraceuticals, nootropics and psychoactives. The active substance may comprise, for example, nicotine, caffeine, taurine, theine, vitamins such as B6 or B12 or C, melatonin, cannabinoids, or constituents, derivatives, or combinations thereof. The active substance may comprise one or more constituents, derivatives or extracts of tobacco, cannabis or another botanical.

In some embodiments, the active substance comprises nicotine. In some embodiments, the active substance comprises caffeine, melatonin or vitamin B12. In some embodiments, the precursor material may comprise an extract from other botanical source(s) along with or instead of the tobacco extract.

As noted herein, the extract may comprise or be derived from one or more botanicals or constituents, derivatives or extracts thereof. As used herein, the term "botanical" includes any material derived from plants including, but not limited to, extracts, leaves, bark, fibres, stems, roots, seeds, flowers, fruits, pollen, husk, shells or the like. The extract may comprise or be derived from botanicals in the form of liquid, gas, solid, powder, dust, crushed particles, granules, pellets, shreds, strips, sheets, or the like. Example botanicals are tobacco, eucalyptus, star anise, hemp, cocoa, cannabis, fennel, lemongrass, peppermint, spearmint, rooibos, chamomile, flax, ginger, ginkgo biloba, hazel, hibiscus, laurel, licorice (liquorice), matcha, mate, orange skin, papaya, rose, sage, tea such as green tea or black tea, thyme, clove, cinnamon, coffee, aniseed (anise), basil, bay leaves, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary, saffron, lavender, lemon peel, mint, juniper, elderflower, vanilla, wintergreen, beefsteak plant, curcuma, turmeric, sandalwood, cilantro, bergamot, orange blossom, myrtle, cassis, valerian, pimento, mace, damien, maijoram, olive, lemon balm, lemon basil, chive, carvi, verbena, tarragon, geranium, mulberiy, ginseng, theanine, theacrine, maca, ashwagandha, damiana, guarana, chlorophyll, baobab or any combination thereof. The mint may be chosen from the following mint varieties: Mentha Arventis, Mentha c.v., Mentha niliaca, Mentha piperita, Mentha piperita citrata c.v., Mentha piperita c.v., Mentha spicata crispa, Mentha cardifolia, Mentha longifolia, Mentha suaveolens variegata, Mentha pulegium, Mentha spicata c.v. and Mentha suaveolens

In some embodiments, the extract comprises or is derived from one or more botanicals or constituents, derivatives or extracts thereof selected from eucalyptus, star anise, cocoa and hemp. In some embodiments, the extract comprises or is derived from one or more botanicals or constituents, derivatives or extracts thereof selected from rooibos and fennel.

In some embodiments, the aerosol-generating material and/or the precursor material comprises one or more cannabinoid compounds selected from the group consisting of: cannabidiol (CBD), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM) and cannabielsoin (CBE), cannabicitran (CBT).

The aerosol-generating material and/or the precursor material may comprise one or more cannabinoid compounds selected from the group consisting of cannabidiol (CBD) and THC (tetrahydrocannabinol). The aerosol-generating material and/ or the precursor material may comprise cannabidiol (CBD).

The aerosol-generating material and/or the precursor material may comprise nicotine and cannabidiol (CBD).

The aerosol-generating material and/or the precursor material may comprise nicotine, cannabidiol (CBD), and THC (tetrahydrocannabinol).

The aerosol-generating material further comprises an aerosol-former material. In some embodiments, this aerosol-former material is included in the precursor material.

The aerosol-former material may comprise one or more constituents capable of forming an aerosol. The aerosol-former maybe, for instance, a polyol aerosol generator or a non-polyol aerosol generator. It may be a solid or liquid at room temperature, but preferably is a liquid at room temperature.

In some embodiments, the aerosol-former material may comprise one or more of glycerine, glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-Eiythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauiyl acetate, lauric acid, myristic acid, and propylene carbonate.

In some embodiments, the aerosol former comprises one or more polyhydric alcohols, such as propylene glycol, triethylene glycol, 1 ,3-butanediol and glycerin; esters of polyhydric alcohols, such as glycerol mono-, di- or triacetate; and/or aliphatic esters of mono-, di- or polycarboxylic acids, such as dimethyl dodecanedioate and dimethyl tetradecanedioate. In some embodiments, the aerosol-former material comprises one or more compounds selected from eiythritol, propylene glycol, glycerol, vegetable glycerine (VG), triacetin, sorbitol and xylitol.

In some embodiments, the aerosol-former material comprises, consists essentially of or consists of glycerol. Glycerol provides a visible aerosol when the aerosol-generation device is used. It is common that consumers like the aerosol-generation device to provide a visible aerosol, as this enables the consumer to visualise the product and what they are consuming. This makes glycerol a desirable choice for aerosol former material.

Propylene glycol has the benefit that it is a better flavour carrier than glycerol.

A combination of two or more aerosol forming agents may be used, in equal or differing proportions.

In some embodiments, the precursor material comprises at least about 1 wt%, at least about 5 wt%, at least about 10 wt%, or at least about 20 wt% aerosol-former material (calculated on a wet weight basis). Additionally or alternatively, the precursor material may comprise up to about 40 wt%, up to about 35, up to about 30 wt%, up to about 25 wt%, up to about 20 wt%, or up to about 10 wt% aerosol-former material (calculated on a wet weight basis).

In embodiments of the invention in which the aerosol-former material is glycerol, the precursor material may comprise at most 36 wt% of glycerol. The inventors have demonstrated that dry weight inclusion levels up to 36 wt% (calculated on a dry weight basis) of aerosol-former material are possible.

The amount of glycerol in the precursor material, and therefore the dried aerosol material, is important because it is both an aerosol-forming material and also a plasticizer. If the concentration of glycerol it too high, it may be detrimental to a critical temperature of the product during the freeze-drying process and may result in collapse of the product if the critical temperature of the formulation is exceeded. On the other hand, sufficient glycerol should be included to provide the consumer with an adequate and pleasing aerosol. As glycerol and some other aerosol-former materials are considered to have anti-freeze properties, it is particularly surprising that it is possible to freeze-dry a precursor material comprising such materials. Nevertheless, the inventors have discovered that precursor materials comprising glycerol may be freeze dried to form a highly useful aerosol-generating material.

In some embodiments, the dried aerosol-generating material may comprise at least about i wt%, at least about 5 wt%, at least about 10 wt%, at least about 20 wt%, at least about 30 wt%, or at least about 40 wt% aerosol-former material (calculated on a dry weight basis).

In some embodiments, the dried aerosol-generating material may comprise from about 1 to about 34 wt%, or from about 17 to about 34 wt% aerosol-former material (calculated on a dry weight basis). In some embodiments in which the aerosol-former material is glycerol, the dried aerosol-generating material may comprise from about 13 to about 34 wt% glycerol (calculated on a diy weight basis).

In embodiments in which Burley tobacco is used, the aerosol-generating material may comprise from about 17 to about 36 wt% of glycerol. The amount of glycerol in the aerosol material is important because it is both an aerosol-forming material and a plasticizer. If the concentration of glycerol is too high, it may be detrimental to the critical temperature of the product during the freeze-drying process and may result in collapse of the product if a critical temperature of the formulation is exceeded. On the other hand, sufficient glycerol should be included to provide the consumer with an adequate and pleasing aerosol.

In some embodiments, the aerosol-generating material and/or the precursor material further comprises one or more excipients. In some embodiments, the excipient stabilises and preserves the precursor material and the inventors have found the inclusion of an excipient especially important for stability when the precursor material comprised glycerol as the aerosol-forming material. The excipient may also act as a bulking agent or a filler material. In some embodiments, the inclusion of an excipient may also improve the handleability of the dried aerosol-generating material, helping it to retain its granular form by helping to reduce moisture uptake and the resulting increase in tackiness of the material. The presence of an excipient may also have an effect on the speed of (freeze) diying. Suitable excipients include mannitol, sucrose, trehalose, lactose, sorbitol, raffinose, maltose, dextrans such as Dextran to, Dextran 70, Dextran 90, maltodextrin, gelatin, agar, cyclodextrins, and polyethylene glycols such as PEG 2000-6000, and polyvinylpyrrolidone (PVP 10).

In some embodiments, the aerosol-generating material and/or the precursor material comprises one or more excipients in an amount of from o to about 40 wt% on a wet weight basis. In some embodiments, the precursor material may comprise at least about 1 wt%, at least about 10 wt%, at least about 20 wt%, at least about 30 wt%, and/or up to about 40 wt%, up to about 30%, up to about 20 wt%, or up to about 10 wt% excipient on a wet weight basis.

In some embodiments, the aerosol-generating material may comprise at least about 0.1 wt%, at least about 10 wt%, at least about 20 wt%, or at least about 25 wt% excipient (calculated on a diy weight basis). In some embodiments, the aerosol-generating material may comprise up to about 25%, up to about 20 wt%, up to about 15 wt%, or up to about 10 wt% excipient (calculated on a dry weight basis). In an exemplary embodiment, the aerosol-generating material comprises about 36 wt% glycerol, about 45 wt% tobacco extract, and about 19 wt% excipient on a diy weight basis.

In another exemplaiy embodiment, the aerosol-generating material comprises from about 17 to about 39 wt% glycerol, from about 41 to about 76 wt% tobacco extract, and from o to about 28 wt% excipient on a dry weight basis.

In embodiments in which the excipient is agar, the precursor material may comprise o wt%, about 5 wt%, or about 10 wt% agar. The inventors have found that agar makes the precursor material more viscous and that the freeze-drying process is easier when the precursor material comprises a lower concentration of the agar excipient.

In some embodiments, the precursor material comprises about 50 wt% tobacco extract, from o to about 36 wt% aerosol forming agent (for example, from o to about 15 v/v%) and from o to about 40 wt% (for example, about 37.5 v/v%) excipient. The tobacco extract may comprise about 55 wt% tobacco solids and the overall tobacco solids content of the precursor material is about 27.5 wt%.

In some embodiments, the precursor material comprises about 50 wt% tobacco extract, up to about 36 wt% (for example, about 15 v/v%) glycerol and from o to about 40 wt%

(for example, about 37.5 v/v%) excipient. The tobacco extract may comprise about 55 wt% tobacco solids and the overall tobacco solids content of the precursor material is about 27.5 wt%. Some sample formulations of dried aerosol-generating materials formed from aqueous tobacco extracts are summarised in Table 1 below, with the amounts provided on a dry weight basis. Glycerol may be used as an aerosol-former material, but can be replaced or partially replaced with one or more other aerosol-former material such as those disclosed herein. The excipient used may be a dextran such as Dextran 70. Again, this may be replaced or partially replaced with alternative excipients, such as those disclosed herein.

Table 1

The percentage content of nicotine in the formulation will depend on the type of tobacco used, and the presence of other components, i.e. the aerosol-former and the excipient.

In some embodiments, the aerosol-generating material and/or the precursor material comprises one or more binders. In some embodiments the one or more binder is selected from the group consisting of: thermoreversible gelling agents, such as gelatin; starches; polysaccharides; pectins; celluloses; cellulose derivatives, such as carboxymethylcellulose; and alginates. In some embodiments, the aerosol-generating material and/or the precursor material comprises one or more flavour-modifier, flavour or flavourant. This may be derived from the extract or it may be added. As used herein, the terms "flavour" and "flavourant" refer to materials which, where local regulations permit, may be used to create a desired taste, aroma or other somatosensorial sensation in a product for adult consumers. They may include naturally occurring flavour materials, botanicals, extracts of botanicals, synthetically obtained materials, or combinations thereof (e.g., tobacco, cannabis, licorice (liquorice), hydrangea, eugenol, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, maple, matcha, menthol, Japanese mint, aniseed (anise), cinnamon, turmeric, Indian spices, Asian spices, herb, wintergreen, cherry, berry, red berry, cranberry, peach, apple, orange, mango, clementine, lemon, lime, tropical fruit, papaya, rhubarb, grape, durian, dragon fruit, cucumber, blueberry, mulberry, citrus fruits, Drambuie, bourbon, scotch, whiskey, gin, tequila, rum, spearmint, peppermint, lavender, aloe vera, cardamom, celery, cascarilla, nutmeg, sandalwood, bergamot, geranium, khat, naswar, betel, shisha, pine, honey essence, rose oil, vanilla, lemon oil, orange oil, orange blossom, cheriy blossom, cassia, caraway, cognac, jasmine, ylang-ylang, sage, fennel, wasabi, piment, ginger, coriander, coffee, hemp, a mint oil from any species of the genus Mentha, eucalyptus, star anise, cocoa, lemongrass, rooibos, flax, ginkgo biloba, hazel, hibiscus, laurel, mate, orange skin, rose, tea such as green tea or black tea, thyme, juniper, elderflower, basil, bay leaves, cumin, oregano, paprika, rosemary, saffron, lemon peel, mint, beefsteak plant, curcuma, cilantro, myrtle, cassis, valerian, pimento, mace, damien, maijoram, olive, lemon balm, lemon basil, chive, carvi, verbena, tarragon, limonene, thymol, camphene), flavour enhancers, bitterness receptor site blockers, sensorial receptor site activators or stimulators, sugars and/or sugar substitutes (e.g., sucralose, acesulfame potassium, aspartame, saccharine, cyclamates, lactose, sucrose, glucose, fructose, sorbitol, or mannitol), and other additives such as charcoal, chlorophyll, minerals, botanicals, or breath freshening agents. They may be imitation, synthetic or natural ingredients or blends thereof. They may be in any suitable form, for example, liquid such as an oil, solid such as a powder, or gas.

In some embodiments, the flavour comprises menthol, spearmint and/or peppermint.

In some embodiments, the flavour comprises flavour components of cucumber, blueberry, citrus fruits and/or redberry. In some embodiments, the flavour comprises eugenol. In some embodiments, the flavour comprises flavour components extracted from tobacco. In some embodiments, the flavour comprises flavour components extracted from cannabis.

In some embodiments, the flavour may comprise a sensate, which is intended to achieve a somatosensorial sensation which are usually chemically induced and perceived by the stimulation of the fifth cranial nerve (trigeminal nerve), in addition to or in place of aroma or taste nerves, and these may include agents providing heating, cooling, tingling, numbing effect. A suitable heat effect agent may be, but is not limited to, vanillyl ethyl ether and a suitable cooling agent may be, but not limited to eucolyptol, WS-3.

In some embodiments, the aerosol-generating material and/or the precursor material comprises one or more other functional materials, which may comprise one or more of pH regulators, colouring agents, preservatives, fillers, stabilizers, and/or antioxidants.

In some embodiments, the aerosol-generating material and/or the precursor material contains a filler component. The filler component is generally a non-tobacco component, that is, a component that does not include ingredients originating from tobacco. In some embodiments, the precursor material comprises less than 60 wt% of a filler, such as from 1 wt% to 60 wt%, or 5 wt% to 50 wt%, or 5 wt% to 30 wt%, or 10 wt% to 20 wt% on a wet weight basis.

The filler, if present, may comprise one or more inorganic filler materials such as calcium carbonate, perlite, vermiculite, diatomaceous earth, colloidal silica, magnesium oxide, magnesium sulphate, magnesium carbonate, and suitable inorganic sorbents, such as molecular sieves. The filler may comprise one or more organic filler materials such as wood pulp, hemp fibre, cellulose and cellulose derivatives.

In some embodiments, the dried aerosol-generating material is in the form of a gel. A gelling agent may be added to the aerosol-generating material, the precursor material or may be optionally omitted. The gelling agent may comprise one or more compounds selected from cellulosic gelling agents, non-cellulosic gelling agents, guar gum, acacia gum and mixtures thereof. In some embodiments, the cellulosic gelling agent is selected from the group consisting of: hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), cellulose acetate propionate (CAP) and combinations thereof. In some embodiments, the gelling agent comprises (or is) one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose (HPMC), carboxymethylcellulose, guar gum, or acacia gum.

In some embodiments, the gelling agent comprises (or is) one or more non-cellulosic gelling agents, including, but not limited to, agar, xanthan gum, gum Arabic, guar gum, locust bean gum, pectin, carrageenan, starch, alginate, and combinations thereof. In preferred embodiments, the non-cellulose based gelling agent is alginate or agar.

The aerosol-generating material and/or the precursor material may comprise an acid. The acid may be an organic acid. In some of these embodiments, the acid may be at least one of a monoprotic acid, a diprotic acid and a triprotic acid. In some such embodiments, the acid may contain at least one carboxyl functional group. In some such embodiments, the acid may be at least one of an alpha-hydroxy acid, carboxylic acid, dicarboxylic acid, tricarboxylic acid and keto acid. In some such embodiments, the acid may be an alpha-keto acid.

In some such embodiments, the acid may be at least one of succinic acid, lactic acid, benzoic acid, citric acid, tartaric acid, fumaric acid, levulinic acid, acetic acid, malic acid, formic acid, sorbic acid, benzoic acid, propanoic and pyruvic acid. In some embodiments, the acid is selected from one of lactic acid, benzoic acid and levulinic acid.

In other embodiments the acid may be an inorganic acid. In some of these embodiments the acid may be a mineral acid. In some such embodiments, the acid may be at least one of sulphuric acid, hydrochloric acid, boric acid and phosphoric acid.

The inclusion of an acid may be beneficial in embodiments in which the aerosolgenerating material and/or the precursor material comprises nicotine. In such embodiments, the presence of an acid may stabilise dissolved species in the slurry from which the aerosol-generating material is formed. The presence of the acid may reduce or substantially prevent evaporation of nicotine during drying of the slurry, thereby reducing loss of nicotine during manufacturing.

In certain embodiments, the aerosol-generating material comprises a gelling agent comprising a cellulosic gelling agent and/or a non-cellulosic gelling agent, an active substance and an acid.

The dried aerosol-generating material may be in any solid form. For example, the aerosol-generating material may be in the form of particles, granules or powder. The aerosol-generating material may be in the form of a monolithic form, tablet, agglomerate or “cake”. In some embodiments, the aerosol-generating material formed by freeze- or spray-diying and is then processed with other suitable steps as required and known to the person skilled in the art to provide the dried material in the desired form, for example in the form of particles of the desired size(s).

In some embodiments, the aerosol-generating material is in the form of granules. The granules may be of any size, cross-sectional shape or mass. The aerosol-generating material in the form of granules is advantageous due to the high surface area to volume ratio, which positively impacts the release of volatiles from the material. This form also facilitates incorporation of the material into an aerosol provision system.

In some embodiments, the aerosol-generating material is free-flowing and non-sticky, and this aids the further processing and handling of the aerosol-generating material. Smaller granule particles have a greater surface area to volume ratio and they may therefore exhibit enhanced release of tobacco constituents compared to particles of larger sizes.

In some embodiments, it may be desirable for the particles in the precursor composition, to have an average particle size of no greater than about 3 mm, of no greater than 1 mm, of no greater than about 0.5 mm, or to have an average particle size of no greater than about 0.3 mm, when measured by sieving.

In some embodiments, the average particle size is within the range of about 0.1 to about 3 mm, of about 0.1 to about 1 mm, of about 0.1 to about 0.5 mm, of about 0.1 to about

0.4 mm, or in the range of about 0.2 to about 0.3 mm. In some embodiments, at least about 90% of the particles of the precursor composition will have a particle size within the range of about 0.1 to about 3 mm, or of about 0.1 to about 1 mm, or of about 0.1 to about 0.5 mm. In some embodiments, at least about 90% of the tobacco particles of the precursor composition will have a particle size within the range of about 0.1 to about 3 mm, or of about 0.1 to about 1 mm, or of about 0.1 to 0.5 mm. In some embodiments, none of the particles in the precursor composition have a particle size greater than 5 mm, greater than 4 mm, greater than 2 mm, greater than 1.5 mm, or greater than about 1 mm. In some embodiments, the average particle size is less than 1 mm. When preparing the precursor compositions to be dried, the particle size of any solid material present may be reduced by grinding, shredding, cutting or crushing the plant material. Suitable machinery to create such plant particles includes, for example, shredders, cutters, or mills, such as hammer mills, roller mills or other types of commercially available milling machinery. The size of the plant particles is selected to provide particles which can be readily prepared from a variety of different types of plant material, having the properties described herein, and which provide a source of plant constituents that are readily released.

Particles of the aerosol -generating material of a smaller size may be advantageous for aerosol generation. Without wishing to be bound by any particular theory, smaller particles may have a greater surface area to volume ratio, which may improve aerosol generation. In some embodiments, the dried aerosol-generating material readily forms particles with an average size of smaller than 1 mm. In some embodiments, the particles may be as small as 10 pm or even as small as 1 pm. The size of the particles may be determined by sieving or by observing the particles by SEM.

In some embodiments, the freeze dried precursor material is ground into particles and may be sieved to exclude particles that are considered too small or too large to be used as aerosol-generating material.

In some embodiments, aerosol-generating material used in the present invention has a particle size distribution Dio from about 5 to about 25 pm (meaning that 10% of the particles in the tested sample are smaller than the value), a particle size distribution D50 from about 30 to about 200 pm (meaning that 50% of the particles in the tested sample are smaller than the value), and a particle size distribution D90 from about 500 to about 2500 pm (meaning that 90% of the particles in the tested sample are smaller than the value). These values are determined using particle size analyser Microtrac CamSizer® X2. Percentages referred to here are volume percentages.

In some embodiments, the freeze dried material used as the aerosol-generating material according to the present invention has a particle size distribution Dio from about 8 to about 15 pm, a particle size distribution D50 from about 50 to about 150 pm, and a particle size distribution D90 from about 900 to about 1700 pm.

In some embodiments, the Dio mean is from about 10 to about 15 pm, the D50 mean from about 40 to about 140 pm and the D90 mean from about 800 to about 1600 pm.

Spray-drying and freeze-drying

The drying methods used to diy the precursor material may be any suitable drying process, including freeze-drying or spray-drying processes. The drying process used must be compatible with the precursor material and the desired make-up of the aerosol-generating material. As it may be desirable for the aerosol-generating material to include active and/or flavour substances derived from the extract in the precursor material, it is important to select a drying method that will retain a sufficient amount of these components.

In small scale examples, the precursor material is freeze-dried using freeze-drying microscopy, for example using a Lyostat freeze-drying microscope.

In a spray-drying process, the precursor material is sprayed and rapidly dried using a hot gas. The use of spray drying provides several advantages to the present invention: the dry particle size can be controlled and may be consistent; tobacco or flavour extracts or materials are heat sensitive but can still be spray-dried at relatively high inlet temperatures; a short residence time in the spray-diying equipment is required; and minimal loss of flavour/volatiles. This makes the process adaptable to reduce loss of volatile compounds and maintain the desired flavour of the aerosol-generating material.

Freeze-drying, also known as lyophilisation or cryodesiccation, is a process in which the precursor material is frozen, the temperature lowered and the water is removed via sublimation under reduced pressure conditions. Without wishing to be bound by any specific theory, it is believed that the low processing temperatures and rapid water loss via sublimation avoid changes in the aerosol-generating material’s structure, appearance and characteristics. This process preserves the structure of the precursor material, and reduces the loss and decomposition of volatile flavour compounds. The dried aerosol-generating material has a lower water content than the precursor material. The water content of the aerosol-generating material may be at most about 0.5 wt%, about 1 wt%, about 2%, about 5 wt%, about 10 wt%, or about 20 wt% (calculated on a wet weight basis). The water content of the dried aerosol -generating material may be reduced from the precursor material by at least about 50 wt%, about 60 wt%, about 70 wt%, about 80 wt%, about 90 wt%, about 95 wt%, about 98 wt%, or by about too wt%. In some embodiments the dried aerosol-generating material has a water content of less than about 5 wt%, less than about 4 wt%, less than about 3 wt%, less than about 2 wt% or less than about 1 wt% (calculated on a wet weight basis), as measured by gas chromatography-thermal conductivity detector (GC-TCD) or Karl Fischer measurement.

In an exemplary embodiment of the invention, the precursor material comprises Burley tobacco extract and a water content of 60 wt%. After the freeze-drying operation described herein, the dried aerosol-generating material has a water content of 3 wt%.

A lower water content of the dried aerosol-generating material is associated with longer shelf-life and stability. However, very low water content may be associated be a brittle structure and a smaller particle size, as well as taking longer to process. The material is also very hygroscopic. If the water content of the dried aerosol-generating material is too high on the other hand, the desired increased stability may not be achieved. The dried aerosol-generating material may also not be as easy to handle with higher water content, with the material becoming sticky.

The inventors have found that when the precursor material comprises an excipient, the precursor material may be better suited to being dried via spray-drying (compared to a precursor material without an excipient). Without wishing to be bound by any particular theoiy, it is speculated that increasing the amount of the excipient in the precursor material raises the glass transition temperature to above too°C and this affects the physical properties of the material, making it more suitable for spray diying.

Use of the compositions The compositions comprising the aerosol-generating material and coating may be used in combustible or non-combustible aerosol provision systems, or in an aerosol-free delivery system. In some embodiments, the compositions comprising the aerosol-generating material and moisture impermeable coating may be provided on a carrier or support. The support may have any shape, size or configuration. For example, the composition may be provided in or on a rod-shaped support, or on a surface of a flat consumable or support.

In some embodiments, the support maybe an additional aerosol-generating material, such as tobacco material in the form of cut rag or reconstituted tobacco material. The composition may be added to the additional aerosol-generating material to introduce the dried aerosol-generating material included in the composition. Additionally, the composition may be introduced in order to stabilise or structurally strengthen the additional aerosol-generating material.

In some embodiments, the support consists of or comprises a heating material that comprises one or more materials selected from the group consisting of: an electrically- conductive material, a magnetic material, and a magnetic electrically-conductive material. In some embodiments, the heating material may comprise a metal or a metal alloy. In some embodiments, the heating material may comprise one or more materials selected from the group consisting of: aluminium, gold, iron, nickel, cobalt, conductive carbon, graphite, plain-carbon steel, stainless steel, ferritic stainless steel, copper, and bronze.

In some embodiments, the heating material may be heated by induction heating. Induction heating is a process in which an electrically-conductive object is heated by penetrating the object with a vaiying magnetic field. In some embodiments, the heating material may be heated by resistive heating. In such embodiments, the heating material is connected to a power supply. Alternatively, the heating may be microwave heating or infrared heating.

The aerosol-generating material may be provided in the form of individual units or portions, that can be heated individually and independently of one another and which can each produce one puff of aerosol or a series of puffs that may be used in a single session of use.

In other embodiments, the coated composition may be provided as one or more tablets, beads or granules and these may, for example, be provided in a cartridge, pod or pouch.

Alternatively, a coated tablet or bead may be provided for direct insertion into a device, for example into an appropriately configured chamber or receptacle of an aerosolgenerating device. The present invention also relates to a consumable or article, comprising an aerosolgenerating material comprising a dried precursor material comprising an extract from a flavour- and/or active-containing plant material, and a moisture impermeable coating. The moisture impermeable coating surrounds the aerosol-generating material. In some embodiments, the composition disclosed herein is provided in the consumable.

A consumable is an article comprising aerosol-generating material, part or all of which is intended to be consumed during use by a user. In this case, the aerosol-generating material, or at least some of the aerosol-generating material, is in the form of the composition disclosed herein, comprising the aerosol-generating material and moisture-impermeable coating.

A consumable may comprise one or more other components, such as an aerosolgenerating material storage area, an aerosol-generating material transfer component, an aerosol generation area, a housing, a wrapper, a mouthpiece, a filter and/or an aerosol-modifying agent. A consumable may also comprise an aerosol generator, such as a heater, that emits heat to cause the aerosol-generating material to generate aerosol in use. The heater may, for example, comprise combustible material, a material heatable by electrical conduction, or a susceptor. The consumable may be any shape or size that is appropriate to the smoking device. In a preferred embodiment of the invention, the consumable is a rod shape.

In some embodiments, the moisture impermeable coating surrounds the aerosolgenerating material but may be separate from the composition. For example, the moisture impermeable coating may surround the composition (thereby surrounding the aerosol-generating material within the composition). In some embodiments, the moisture impermeable coating may be provided as a film or wrapper, optionally being deposited on a moisture permeable carrier.

In some embodiments, the composition comprising an aerosol-generating material and a moisture impermeable coating is provided in an aerosol-generating device such as a tobacco-heating product (THP) or hybrid e-cigarette product. Advantageously, the composition may be used directly as a solid substrate and the composition is directly heated without burning to provide an inhalable aerosol. In some embodiments, heating the composition will first cause the coating to decompose, to breach the barrier it forms around the aerosol-generating material. Then, the aerosolised components of the aerosol-generating material, for example the glycerol, nicotine and/or tobacco flavour will be released.

As the composition itself and/or the moisture impermeable coating protects the moisture sensitive aerosol-generating material, it is not necessary for the composition or the consumable to be stored in reduced humidity conditions prior to use.

In some embodiments, the composition comprising an aerosol-generating material and a moisture impermeable coating may be incorporated into the consumable in the absence of any carrier or other substrate material that would need to be heated.

However, in some embodiments, the composition may be applied to a fibrous paper material to provide reconstituted tobacco. This process may be analogous to the existing process of preparing reconstituted tobacco by applying tobacco extract to fibrous paper material, and modified by replacing the tobacco extract with the composition comprising an aerosol-generating material and a moisture impermeable coating. This is advantageous as the aerosol-generating material can be incorporated into an existing manufacturing process, but with the improved shelflife as discussed herein.

“Paper reconstituted tobacco” refers to tobacco material formed by a process in which tobacco feedstock is extracted with a solvent to afford an extract of solubles and a residue comprising fibrous material, and then the extract (usually after concentration, and optionally after further processing) is recombined with fibrous material from the residue (usually after refining of the fibrous material, and optionally with the addition of a portion of non-tobacco fibres) by deposition of the extract onto the fibrous material. The process of recombination resembles the process for making paper.

The paper reconstituted tobacco described herein may be prepared by methods which are known to those skilled in the art for preparing paper reconstituted tobacco.

In some embodiments, the total mass of the dried aerosol-generating material included for use in a deliveiy system is up to about 200 mg, up to about 190 mg, up to about 180 mg, up to about 170 mg, up to about 160 mg, up to about 150 mg, up to about 140 mg, up to about 130 mg, up to about 120 mg, up to about no mg, up to about too mg, up to about 90 mg, up to about 80 mg, up to about 70 mg, up to about 60 mg, or up to about 50 mg.

Alternatively or in addition, the total mass of the dried aerosol-generating material included may be at least about 5 mg, at least about 10 mg, at least about 15 mg, at least about 20 mg, at least about 25 mg, at least about 30 mg, at least about 35 mg, at least about 40 mg, at least about 45 mg, or at least about 50 mg.

In some embodiments, the total mass of the dried aerosol-generating material is sufficient to provide aerosol, for example, for up to about 10 puffs to be generated in a single session or over a series of multiple sessions. In such embodiments, the total mass of the dried aerosol-generating material provided is from about 10 to too mg, or from about 25 to about 50 mg. Delivery Systems

The delivery systems described herein can be combustible aerosol provision systems, non-combustible aerosol provision systems or an aerosol-free delivery systems.

As used herein, the term “delivery system” is intended to encompass systems that deliver at least one substance to a user, and includes: combustible aerosol provision systems, such as cigarettes, cigarillos, cigars, and tobacco for pipes or for roll-your-own or for make-your-own cigarettes (whether based on tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, tobacco substitutes or other smokable material); non-combustible aerosol provision systems that release compounds from an aerosol-generating material without combusting the aerosol-generating material, such as electronic cigarettes, tobacco heating products, and hybrid systems to generate aerosol using a combination of aerosol-generating materials; and aerosol-free deliveiy systems that deliver the at least one substance to a user orally, nasally, transdermally or in another way without forming an aerosol, including but not limited to, lozenges, gums, patches, articles comprising inhalable powders, and oral products such as oral tobacco which includes snus or moist snuff, wherein the at least one substance may or may not comprise nicotine.

According to the present disclosure, a “combustible” aerosol provision system is one where a constituent aerosol-generating material of the aerosol provision system (or component thereof) is combusted or burned during use in order to facilitate deliveiy of at least one substance to a user.

In some embodiments, the delivery system is a combustible aerosol provision system, such as a system selected from the group consisting of a cigarette, a cigarillo and a cigar.

In some embodiments, the disclosure relates to a component for use in a combustible aerosol provision system, such as a filter, a filter rod, a filter segment, a tobacco rod, a spill, an aerosol-modifying agent release component such as a capsule, a thread, or a bead, or a paper such as a plug wrap, a tipping paper or a cigarette paper.

According to the present disclosure, a “non-combustible” aerosol provision system is one where a constituent aerosol-generating material of the aerosol provision system (or component thereof) is not combusted or burned in order to facilitate delivery of at least one substance to a user.

In some embodiments, the delivery system is a non-combustible aerosol provision system, such as a powered non-combustible aerosol provision system.

In some embodiments, the non-combustible aerosol provision system is an electronic cigarette, also known as a vaping device or electronic nicotine delivery system (END), although it is noted that the presence of nicotine in the aerosol-generating material is not a requirement. In some embodiments, the non-combustible aerosol provision system is an aerosolgenerating material heating system, also known as a heat-not-burn system. An example of such a system is a tobacco heating system. In some embodiments, the non-combustible aerosol provision system is a hybrid system to generate aerosol using a combination of aerosol-generating materials, one or a plurality of which may be heated and may be a composition comprising an aerosolgenerating material and a moisture impermeable coating. Each of the aerosolgenerating materials may be, for example, in the form of a solid, liquid or gel and may or may not contain nicotine. In some embodiments, the hybrid system comprises a liquid or gel aerosol-generating material and a solid aerosol-generating material. The solid aerosol-generating material may comprise, for example, tobacco or a non-tobacco product. Typically, the non-combustible aerosol provision system may comprise a non- combustible aerosol provision device and a consumable for use with the non- combustible aerosol provision device.

In some embodiments, the disclosure relates to consumables comprising a composition comprising an aerosol-generating material and a moisture impermeable coating and configured to be used with non-combustible aerosol provision devices. These consumables are sometimes referred to as articles throughout the disclosure.

In some embodiments, the non-combustible aerosol provision system, such as a non- combustible aerosol provision device thereof, may comprise a power source and a controller. The power source may, for example, be an electric power source or an exothermic power source. In some embodiments, the exothermic power source comprises a carbon substrate which may be energised so as to distribute power in the form of heat to a composition comprising an aerosol -generating material and a moisture impermeable coating or to a heat transfer material in proximity to the exothermic power source.

In some embodiments, the non-combustible aerosol provision system may comprise an area for receiving the consumable, an aerosol generator, an aerosol generation area, a housing, a mouthpiece, a filter and/ or an aerosol-modifying agent. In some embodiments, the consumable for use with the non-combustible aerosol provision device may comprise a composition comprising an aerosol-generating material and a moisture impermeable coating, an aerosol-generating material storage area, an aerosol-generating material transfer component, an aerosol generator, an aerosol generation area, a housing, a wrapper, a filter, a mouthpiece, and/or an aerosolmodifying agent.

Figure i is a side-on cross sectional view of a consumable or article i for use in an aerosol deliveiy system. The article i comprises a mouthpiece segment 2, and an aerosol generating segment 3.

The aerosol generating segment 3 is in the form of a cylindrical rod and comprises a composition comprising an aerosol-generating material and a moisture impermeable coating 4. The composition can be any of the compositions comprising an aerosol- generating material and a moisture impermeable coating discussed herein.

Although described above in rod form, the aerosol-generating segment 3 can be provided in other forms, for instance a plug, pouch, or packet of material within an article.

The mouthpiece segment 2, in the illustrated embodiment, includes a body of material 5 such as a fibrous or filamentary tow.

The rod-shaped consumable 1 further comprises a wrapper 6 circumscribing the mouthpiece segment 2 and aerosol generating segment 3, such as a paper wrapper.

Figure 2 shows an example of a non-combustible aerosol provision device too for generating aerosol from an aerosol -generating medium/ material such as the composition of a consumable no, as described herein. In broad outline, the device too may be used to heat a replaceable article no comprising the aerosol-generating medium, for instance an article 1 as illustrated in Figure 1 or as described elsewhere herein, to generate an aerosol or other inhalable medium which is inhaled by a user of the device too. The device too and replaceable article no together form a system. The device too comprises a housing 102 (in the form of an outer cover) which surrounds and houses various components of the device too. The device too has an opening 104 in one end, through which the article no may be inserted for heating by a heating assembly. In use, the article no may be fully or partially inserted into the heating assembly where it may be heated by one or more components of the heater assembly.

The device too of this example comprises a first end member 106 which comprises a lid 108 which is moveable relative to the first end member 106 to close the opening 104 when no article no is in place. In Figure 2, the lid 108 is shown in an open configuration, however the lid 108 may move into a closed configuration. For example, a user may cause the lid 108 to slide in the direction of arrow “B”.

The device too may also include a user-operable control element 112, such as a button or switch, which operates the device too when pressed. For example, a user may turn on the device too by operating the switch 112.

The device too may also comprise an electrical component, such as a socket/port 114, which can receive a cable to charge a batteiy of the device too. For example, the socket 114 may be a charging port, such as a USB charging port. In some embodiments, the substance to be delivered may be a composition comprising an aerosol-generating material and a moisture impermeable coating, and optionally another aerosol-generating material that may or may not be heated. As appropriate, the composition and other aerosol-generating material may comprise one or more active constituents, one or more flavours, one or more aerosol-former materials, and/ or one or more other functional materials.

Stability

The invention enjoys the advantage of longer shelflife than other tobacco extracts. The nicotine content of the precursor and aerosol-generating material after the freeze drying process has been calculated, providing an indication of the amount of nicotine retained following the processing. Compared to the original tobacco extract, the nicotine recovery of the dried aerosol-generating material is at least about 76 wt% on a dry weight basis. The nicotine recoveiy of the dried aerosol-generating material compared to the original tobacco extract may be at least about 60%, at least about 70%, at least about 75%, at least about 80%, or at least about 90% on a diy weight basis. The glycerol content of the precursor and dried aerosol-generating material after the freeze diying process has been calculated, providing an indication of the amount of glycerol retained following the processing. Compared to the precursor material, the glycerol recovery of the dried aerosol-generating material is at least about 85%. The glycerol recovery of the dried aerosol-generating material compared to the precursor material may be at least about 70%, at least about 75%, at least about 80%, at least about 85%, at least about 90% at least about 95% on a dry weight basis. In addition, once surrounded by the moisture impermeable coating, the content of volatile components such as nicotine and flavours, and the content of the aerosolforming material in the aerosol-generating material will be maintained until the composition is heated to generate an aerosol. This will be even without packaging or other protection from exposure to moisture.

Example 1

In a first test, the precursor material comprised essentially of aqueous tobacco extract, and glycerol. The aqueous tobacco extract was diluted further with glycerol up to about 24 wt% (calculated on a dry weight basis). The Burley aqueous tobacco extract had a tobacco solid content of about 40 wt%, and a water content of about 60 wt%. The precursor material was dried via freeze drying.

Example 2

In a further test, the precursor material comprised essentially of aqueous tobacco extract, glycerol and Dextran 70. The glycerol content was about o to about 15 v/v%, or up to about 36 wt% calculated on a diy weight basis. The precursor material was dried via freeze drying.

Example 3 50 mg of the freeze-dried aerosol-generating material of Example 1 or Example 2 is agglomerated to form beads with an average size of from about 1 mm to about 3 mm. A population of beads are then each coated by fluidised bed coating with shellac to provide a complete coating having a thickness of about 30 pm. Example 4 io separate portions, each comprising 5 mg of the freeze-dried aerosol-generating material of Example 1 or Example 2 are deposited on the surface of a support comprising aluminium sections which can be heated by magnetic hysteresis heating. Each portion of aerosol-generating material is the coated with a 20 pm thick layer of carnauba wax, lignin or polyvinyl alcohol. The support and the portions comprising the aerosol-generating material are then heated to form an aerosol to be inhaled by a consumer.

Example A tablet is formed by pressing too mg of the freeze-dried aerosol-generating material of

Example 1 or Example 2. This tablet is then spray coated with agar or gum arabic to provide a complete coating having a thickness of about 25 pm.

The various embodiments described herein are presented only to assist in understanding and teaching the claimed features. These embodiments are provided as a representative sample of embodiments only, and are not exhaustive and/or exclusive. It is to be understood that advantages, embodiments, examples, functions, features, structures, and/or other aspects described herein are not to be considered limitations on the scope of the invention as defined by the claims or limitations on equivalents to the claims, and that other embodiments may be utilised and modifications may be made without departing from the scope of the claimed invention. Various embodiments of the invention may suitably comprise, consist of, or consist essentially of, appropriate combinations of the disclosed elements, components, features, parts, steps, means, etc., other than those specifically described herein. In addition, this disclosure may include other inventions not presently claimed, but which may be claimed in future.

Claims

1. A composition comprising: an aerosol-generating material comprising a dried precursor material comprising an extract from a flavour- and/ or active-containing plant material, and a moisture impermeable coating surrounding the aerosol-generating material.

2. A composition as claimed in claim 1, wherein the moisture impermeable coating decomposes upon heating to allow volatile components generated by heating the aerosol-generating material to be released.

3. A composition as claimed in claim 2, wherein the moisture impermeable coating decomposes at a temperature at or above about too°C.

4. A composition as claimed in any one of claims 1 to 3, wherein the moisture impermeable coating comprises one or more selected from the group consisting of: a polysaccharide or cellulosic material, or a derivative thereof; a gum; a protein material; a polyol matrix material; a wax; a wax ester; and a polymer

5. A composition as claimed in any one of claims 1 to 4, wherein the moisture impermeable coating completely encapsulates the aerosol-generating material.

6. A composition as claimed in any one of claims 1 to 5, wherein the moisture impermeable coating prevents or retards absorption of moisture by the aerosol- generating material from the surrounding environment.

7. A composition as claimed in any one of claims 1 to 6, wherein the moisture impermeable coating has a thickness of from about 1 pm to about too pm.

8. A composition as claimed in any one of claims 1 to 7, wherein the aerosolgenerating material is in the form of granules.

9. A composition as claimed in claim 8, wherein the granules have a particle size of from about 1 mm to about 4 mm.

10. A composition as claimed in any one of claims 1 to 7, wherein the aerosolgenerating material is in the form of agglomerates or tablets formed from particles.

11. A composition as claimed in claim 10, wherein the agglomerates or tablets have a size from about 3 mm to about 20 mm.

12. A composition as claimed in any one of claims 1 to 7, wherein discrete particles, agglomerates or tablets of the aerosol-generating material are surrounded by the moisture impermeable coating.

13. A composition as claimed in claim 12, wherein the coatings of different discrete particles, agglomerates or tablets of the aerosol -generating material decompose at different temperatures or at different rates to control the release of volatile components generated by heating the dried aerosol-generating material.

14. A composition as claimed in claim 13, wherein different discrete particles or portions of the aerosol-generating material are surrounded by coatings of different thickness.

15. A composition as claimed in claim 13 or 14, wherein different discrete particles or portions of the aerosol-generating material are surrounded by coatings of different coating materials.

16. A composition as claimed in any one of claims 1 to 15, wherein the aerosol- generating material comprises an aerosol-former material.

17. A composition as claimed in any one of claims 1 to 16, the precursor material comprising from about 10 to about 95% by weight extract from a flavour- or activecontaining plant material.

18. A composition as claimed in any one of claims 1 to 17, the precursor material comprising from about 1 to about 36 wt% aerosol-former material.

19. A composition as claimed in any one of claims 1 to 18, the precursor material comprising from o to about 40% by weight of an excipient.

20. A composition as claimed in any one of claims 1 to 19, the aerosol -generating material comprising from about 45 to about 99% by weight dried extract from the flavour- or active-containing plant material.

21. A composition as claimed in any one of claims 1 to 20, the aerosol-generating material comprising from about 1 to about 34% by weight aerosol-former material.

22. A composition as claimed in any one of claims 1 to 21, the aerosol-generating material comprising from o to about 25% by weight of an excipient.

23. A composition as claimed in any one of claims 1 to 22, wherein the plant material is selected from the group consisting of tobacco, eucalyptus, star anise, cocoa and hemp.

24. A composition as claimed in any one of claims 1 to 23, wherein the extract from a flavour- or active-containing plant material is an aqueous extract.

25. A composition as claimed in any one of claims 1 to 24 wherein the extract from a flavour- or active-containing plant material is an aqueous tobacco extract.

26. A composition as claimed in any one of claims 1 to 25, the aerosol -generating material comprising from about 40 to about 99% by weight tobacco solids.

27. A composition as claimed in any one of claims 1 to 26, the aerosol-generating material having a water content of no more than about 5% (calculated on a wet weight basis).

28. A composition as claimed in any one of claims 1 to 27 for use in an aerosol provision system.

29. An article comprising an aerosol-generating material comprising a dried precursor material comprising an extract from a flavour- and/or active-containing plant material, and a moisture impermeable coating surrounding the aerosolgenerating material.

30. An article as claimed in claim 29, comprising a film or wrapper comprising the moisture impermeable coating.

31. An article as claimed in claim 30, wherein the moisture impermeable coating is deposited on a moisture permeable carrier.

32. An article as claimed in any one of claims 29 to 31, comprising the composition as claimed in any one of claims 1 to 28.

33. A non-combustible aerosol-provision system comprising a composition as claimed in any one of claims 1 to 28 or an article as claimed in any one of claims 29 to 32.

34. A method of providing a composition comprising drying a precursor material comprising an extract from a flavour- and/ or active-containing plant material to form an aerosol-generating material and applying a moisture impermeable coating surrounding the aerosol-generating material.

35. A method as claimed in claim 34, wherein the precursor material is dried by spray-drying or freeze-drying.

36. A method as claimed in claim 34 or claim 35, wherein the moisture impermeable coating is applied by a fluidised bed coating process.

37- A method as claimed in claim 34 or claim 35, wherein the moisture impermeable coating is formed as part of the drying step.

38. A method as claimed in claim 37, wherein the moisture impermeable coating forming material is included in the precursor material.