WO2023186984A3 - Chip, device and method for analysing suspended particles - Google Patents

Chip, device and method for analysing suspended particles Download PDF

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Publication number
WO2023186984A3
WO2023186984A3 PCT/EP2023/058145 EP2023058145W WO2023186984A3 WO 2023186984 A3 WO2023186984 A3 WO 2023186984A3 EP 2023058145 W EP2023058145 W EP 2023058145W WO 2023186984 A3 WO2023186984 A3 WO 2023186984A3
Authority
WO
WIPO (PCT)
Prior art keywords
suspended particles
chip
analysing
base body
relates
Prior art date
Application number
PCT/EP2023/058145
Other languages
German (de)
French (fr)
Other versions
WO2023186984A2 (en
Inventor
Stephan Quint
Original Assignee
Cysmic GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102022107729.2A external-priority patent/DE102022107729A1/en
Application filed by Cysmic GmbH filed Critical Cysmic GmbH
Publication of WO2023186984A2 publication Critical patent/WO2023186984A2/en
Publication of WO2023186984A3 publication Critical patent/WO2023186984A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention relates to a chip (10) for the analysis of suspended particles, wherein the chip (10) comprises a base body (12), wherein the base body (12) has at least one microchannel (20) for the passage of the suspended particles. The invention also relates to a device (48), a system (78) and a method for analysing suspended particles.
PCT/EP2023/058145 2022-03-30 2023-03-29 Chip, device and method for analysing suspended particles WO2023186984A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102022107557 2022-03-30
DE102022107557.5 2022-03-30
DE102022107729.2 2022-03-31
DE102022107729.2A DE102022107729A1 (en) 2022-03-30 2022-03-31 Chip, device and method for analyzing suspended particles

Publications (2)

Publication Number Publication Date
WO2023186984A2 WO2023186984A2 (en) 2023-10-05
WO2023186984A3 true WO2023186984A3 (en) 2023-11-23

Family

ID=86006830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2023/058145 WO2023186984A2 (en) 2022-03-30 2023-03-29 Chip, device and method for analysing suspended particles

Country Status (1)

Country Link
WO (1) WO2023186984A2 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050000312A (en) * 2003-06-23 2005-01-03 (주) 세원메디텍 Apparatus For Measuring Blood Cell Deformability
US20060119836A1 (en) * 2003-06-23 2006-06-08 Yun-Hee Ku Apparatus for measuring blood cell deformability
US20090269837A1 (en) * 2003-03-01 2009-10-29 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
US20170087550A1 (en) * 2015-09-29 2017-03-30 Foxconn Interconnect Technology Limited Microfluidic device for detecting cells of blood
WO2021087301A1 (en) * 2019-10-30 2021-05-06 Case Western Reserve University Biochip having microchannel provided with capturing agent for performing cytological analysis
US20210268498A1 (en) * 2020-02-10 2021-09-02 Anpac Bio-Medical Science Co., Ltd. Apparatus and methods for disease detection and treatment
US20220088583A1 (en) * 2019-02-26 2022-03-24 Truvian Sciences, Inc. Assay device and method of use thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090269837A1 (en) * 2003-03-01 2009-10-29 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
KR20050000312A (en) * 2003-06-23 2005-01-03 (주) 세원메디텍 Apparatus For Measuring Blood Cell Deformability
US20060119836A1 (en) * 2003-06-23 2006-06-08 Yun-Hee Ku Apparatus for measuring blood cell deformability
US20170087550A1 (en) * 2015-09-29 2017-03-30 Foxconn Interconnect Technology Limited Microfluidic device for detecting cells of blood
US20220088583A1 (en) * 2019-02-26 2022-03-24 Truvian Sciences, Inc. Assay device and method of use thereof
WO2021087301A1 (en) * 2019-10-30 2021-05-06 Case Western Reserve University Biochip having microchannel provided with capturing agent for performing cytological analysis
US20210268498A1 (en) * 2020-02-10 2021-09-02 Anpac Bio-Medical Science Co., Ltd. Apparatus and methods for disease detection and treatment

Also Published As

Publication number Publication date
WO2023186984A2 (en) 2023-10-05

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