WO2023180283A3 - Electrochemical reactor and processes using the electrochemical reactor - Google Patents

Electrochemical reactor and processes using the electrochemical reactor Download PDF

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Publication number
WO2023180283A3
WO2023180283A3 PCT/EP2023/057142 EP2023057142W WO2023180283A3 WO 2023180283 A3 WO2023180283 A3 WO 2023180283A3 EP 2023057142 W EP2023057142 W EP 2023057142W WO 2023180283 A3 WO2023180283 A3 WO 2023180283A3
Authority
WO
WIPO (PCT)
Prior art keywords
electrochemical reactor
inner electrode
inlet
demethylation
solid
Prior art date
Application number
PCT/EP2023/057142
Other languages
French (fr)
Other versions
WO2023180283A2 (en
Inventor
Oliver KAPPE
Florian Sommer
David CANTILLO
Original Assignee
Karl-Franzens-Universität Graz
Research Center Pharmaceutical Engineering Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl-Franzens-Universität Graz, Research Center Pharmaceutical Engineering Gmbh filed Critical Karl-Franzens-Universität Graz
Publication of WO2023180283A2 publication Critical patent/WO2023180283A2/en
Publication of WO2023180283A3 publication Critical patent/WO2023180283A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B9/00—Cells or assemblies of cells; Constructional parts of cells; Assemblies of constructional parts, e.g. electrode-diaphragm assemblies; Process-related cell features
    • C25B9/01—Electrolytic cells characterised by shape or form
    • C25B9/015—Cylindrical cells
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B15/00—Operating or servicing cells
    • C25B15/08—Supplying or removing reactants or electrolytes; Regeneration of electrolytes
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C25B3/05—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C25B3/07—Oxygen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/01—Products
    • C25B3/09—Nitrogen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/23—Oxidation
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B9/00—Cells or assemblies of cells; Constructional parts of cells; Assemblies of constructional parts, e.g. electrode-diaphragm assemblies; Process-related cell features
    • C25B9/30—Cells comprising movable electrodes, e.g. rotary electrodes; Assemblies of constructional parts thereof
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B9/00—Cells or assemblies of cells; Constructional parts of cells; Assemblies of constructional parts, e.g. electrode-diaphragm assemblies; Process-related cell features
    • C25B9/60—Constructional parts of cells
    • C25B9/67—Heating or cooling means
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B11/00—Electrodes; Manufacture thereof not otherwise provided for
    • C25B11/02—Electrodes; Manufacture thereof not otherwise provided for characterised by shape or form
    • C25B11/034—Rotary electrodes
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B15/00—Operating or servicing cells
    • C25B15/08—Supplying or removing reactants or electrolytes; Regeneration of electrolytes
    • C25B15/081—Supplying products to non-electrochemical reactors that are combined with the electrochemical cell, e.g. Sabatier reactor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to an electrochemical reactor capable of processing an organic mixture comprising a suspension of a solid and a liquid, wherein the electrochemical reactor comprises an inner electrode, an outer electrode, wherein the inner electrode and the outer electrode are arranged concentrically forming a first cavity therebetween, a first inlet configured for introducing the liquid into the first cavity of the electrochemical reactor, a second inlet configured for introducing the solid into the first cavity of the electrochemical reactor, wherein the first inlet and the second inlet are arranged such that the liquid and the solid are introduced separately, wherein the inner electrode is configured to be rotatable around its longitudinal axis, wherein the inner electrode comprises one or more mixing elements. The present invention further relates to processes for the electrochemical N- demethylation and N- and O-demethylation, respectively, of an opioid precursor by means of the electrochemical reactor. The present invention further relates to a one-pot process for the N- and O-demethylation of an opioid precursor.
PCT/EP2023/057142 2022-03-24 2023-03-21 Electrochemical reactor and processes using the electrochemical reactor WO2023180283A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102022107020 2022-03-24
DE102022107020.4 2022-03-24

Publications (2)

Publication Number Publication Date
WO2023180283A2 WO2023180283A2 (en) 2023-09-28
WO2023180283A3 true WO2023180283A3 (en) 2024-01-11

Family

ID=85778816

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2023/057142 WO2023180283A2 (en) 2022-03-24 2023-03-21 Electrochemical reactor and processes using the electrochemical reactor

Country Status (1)

Country Link
WO (1) WO2023180283A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4667037A (en) * 1985-06-06 1987-05-19 E. I. Du Pont De Nemours And Company Dealkylation of opioid ethers
US5198083A (en) * 1989-01-11 1993-03-30 United Kingdom Atomic Energy Authority Electrochemical cell and method of treating waste material therewith
US5788820A (en) * 1996-08-29 1998-08-04 Liu; Cheng-Li Device for electrolyzing water
US20210253452A1 (en) * 2018-08-08 2021-08-19 Commonwealth Scientific And Industrial Research Organisation Electrochemical flow reactor
WO2021249708A1 (en) * 2020-06-10 2021-12-16 Research Center Pharmaceutical Engineering Gmbh Processes for preparing nor-opioid compounds and opioid antagonists by electrochemical n-demethylation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4448364B2 (en) 2004-03-31 2010-04-07 善八 小久見 Rotating electrode body
CN101033228B (en) 2007-04-04 2010-05-19 复旦大学 Method of preparing 14-hydroxy-7,8-dihydromorphone

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4667037A (en) * 1985-06-06 1987-05-19 E. I. Du Pont De Nemours And Company Dealkylation of opioid ethers
US5198083A (en) * 1989-01-11 1993-03-30 United Kingdom Atomic Energy Authority Electrochemical cell and method of treating waste material therewith
US5788820A (en) * 1996-08-29 1998-08-04 Liu; Cheng-Li Device for electrolyzing water
US20210253452A1 (en) * 2018-08-08 2021-08-19 Commonwealth Scientific And Industrial Research Organisation Electrochemical flow reactor
WO2021249708A1 (en) * 2020-06-10 2021-12-16 Research Center Pharmaceutical Engineering Gmbh Processes for preparing nor-opioid compounds and opioid antagonists by electrochemical n-demethylation

Also Published As

Publication number Publication date
WO2023180283A2 (en) 2023-09-28

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