WO2023177394A1

WO2023177394A1 - Dosing syringe

Info

Publication number: WO2023177394A1
Application number: PCT/US2022/020480
Authority: WO
Inventors: Brian J. KOLONIA; Robert A. KOLONIA
Original assignee: New Product Development Concepts, Llc
Priority date: 2022-03-16
Filing date: 2022-03-16
Publication date: 2023-09-21

Abstract

A dosing syringe (1) capable of regulating a quantity of a content (13) ejected therefrom is presented. The syringe (1) includes a barrel (2), a dose selector (4) secured at one end of the barrel (2), and a plunger (3) extendable and retractable with respect to the barrel (2) and the dose selector (4). A tab (28) inwardly extends from either an endcap (18) or a detent ring (17) of the dose selector (4) so as to extend into a recessed region (26) along an outer surface (29) of the plunger (3). The recessed region (26) is bounded by an alignment shoulder (24) and a dosing shoulder (25). The recessed region (26) and the tab (28) are adapted to permit axial movement and rotational movement therebetween. Axial cooperation between the plunger (3) and the endcap (18) or between the plunger (3) and the detent ring (17) at each of two or more angular positions (9) regulates the quantity of content (13) ejected from the barrel (2) whereby the tab (28) is contacted by the dosing shoulder (25) in use to limit extension between the plunger (3) and the barrel (2). The quantity of content (13) ejectable from the syringe (1) differs locationally along the dosing shoulder (25).

Description

PATENT COOPERATION TREATY APPLICATION

TITLE

Dosing Syringe

DESCRIPTION

1. Field

The disclosure generally relates to a syringe, and more particularly to a telescoping syringe including a plunger and a dose selector at one end of a barrel wherein features of the plunger and the dose selector interact so as to quantitatively regulate a content dispensed from the syringe.

2. Background

A variety of syringes are known within the art which enable a user to quantitively regulate the content dispensed therefrom. The technical evolution of such syringes has favored more complex design and/or more complex function. The knock- on effects of complexity are syringes which are more expense, less reliable, more prone to error in use, and less adaptable.

Accordingly, what is required is a syringe enabling a user to quantitively regulate the content dispensed therefrom via a less complex design and a less complex function.

3. Summary

An object of the disclosure is a syringe enabling a user to quantitively regulate the content dispensed therefrom via a less complex design and a less complex function.

In accordance with some embodiments, the dosing syringe includes a barrel, a dose selector at a proximal end of the barrel, and a plunger extendable and retractable with respect to the barrel. The dose selector further includes a detent ring disposed within an endcap. The detent ring and the endcap are disposed about the plunger. The detent ring is rotatably movable via the plunger with respect to the endcap. The detent ring slidingly and rotationally engages the endcap. The detent ring is releasably lockable within the dose selector at two or more angular positions of the plunger with respect to the endcap. The plunger is axially movable with respect to the detent ring and the endcap. The detent ring rotationally cooperates with the endcap so that the plunger axially cooperates with the endcap at each angular position to quantitatively regulate a content ejectable from the barrel. In accordance with other embodiments, the content resides within the barrel prior to ejection from the dosing syringe.

In accordance with other embodiments, the content enters the barrel in use of the dosing syringe.

In accordance with other embodiments, the endcap includes a tab which extends into a recessed region disposed along an outer surface of the plunger wherein the recessed region is axially movable and rotationally movable via the plunger with respect to the tab.

In accordance with other embodiments, the recessed region is bounded by a dosing shoulder and an alignment shoulder.

In accordance with other embodiments, the tab is contacted by the dosing shoulder in use to limit extraction of the plunger from the barrel at each angular position so as to regulate the content entering the barrel.

In accordance with other embodiments, the endcap further incudes another tab which extends into another recessed region disposed along the outer surface of the plunger wherein the recessed regions are separately disposed along the outer surface.

In accordance with other embodiments, the detent ring is rotatably movable by the plunger via locking engagement between the alignment shoulder and a slot of the detent ring.

In accordance with other embodiments, the plunger is axially movable along the alignment shoulder via sliding engagement between the alignment shoulder and a slot of the detent ring.

In accordance with other embodiments, the dose selector further includes a first ring interposed between the barrel and the detent ring.

In accordance with other embodiments, the first ring sealingly engages at least one of the barrel, the plunger, or the detent ring.

In accordance with other embodiments, the first ring is compressed between the barrel and the detent ring wherein the first ring biases the detent ring toward the endcap.

In accordance with other embodiments, the first ring is a spring which biases the detent ring toward the endcap.

In accordance with other embodiments, the detent ring is rotationally fixable in use at each angular position via releasably lockable engagement between two interlock portions at an interface within the dose selector between the detent ring and the first ring.

In accordance with other embodiments, the dose selector further includes a second ring interposed between the first ring and the detent ring.

In accordance with other embodiments, the first ring sealingly engages at least one of the barrel, the plunger, or the second ring.

In accordance with other embodiments, the first ring is compressed between the barrel and the second ring wherein the first ring biases the second ring toward the detent ring and the second ring biases the detent ring toward the endcap.

In accordance with other embodiments, the second ring is a washer wherein the detent ring is slidingly rotatable with respect to at least one of the second ring or the first ring.

In accordance with other embodiments, the first ring is a spring which biases the second ring toward the detent ring and the detent ring toward the endcap.

In accordance with other embodiments, the detent ring is rotationally fixable in use at each angular position via releasably lockable engagement between two interlock portions at an interface within the dose selector between the detent ring and the second ring.

In accordance with other embodiments, the dose selector further includes a second ring interposed between the barrel and the detent ring.

In accordance with other embodiments, the second ring is a washer wherein the detent ring is slidingly rotatable with respect to at least one of the second ring or the barrel.

In accordance with other embodiments, the detent ring is rotationally fixable in use at each angular position via releasably lockable engagement between two interlock portions at an interface between the detent ring and the second ring.

In accordance with other embodiments, the barrel includes a barrel wall with a hub at a distal end and a barrel flange at the proximal end wherein the content is ejectable through the hub and the endcap is secured to the barrel flange at the proximal end.

In accordance with other embodiments, the detent ring is rotationally fixable in use at each angular position via releasably lockable engagement within the dose selector between two interlock portions. In accordance with other embodiments, the two interlock portions are disposed at an interface between the detent ring and an end wall of the endcap.

In accordance with other embodiments, the two interlock portions are disposed at an interface between the detent ring and a side wall of the endcap.

In accordance with other embodiments, the two interlock portions are disposed at an interface between the detent ring and a barrel flange at the proximal end.

In accordance with some embodiments, the dosing syringe includes a barrel, a dose selector at a proximal end of the barrel, and a plunger extendable and retractable with respect to the barrel. The dose selector further includes an endcap and a detent ring. The endcap is interposed between the barrel and the detent ring. The detent ring rotatably engages the endcap. The detent ring includes a tab which extends into a recessed region disposed along an outer surface of the plunger. The recessed region is bounded by a dosing shoulder and an alignment shoulder. The recessed region is axially movable via the plunger with respect to the tab. The tab is rotationally movable via the detent ring with respect to the recessed region. The tab is releasably lockable at two or more angular positions with respect to the recessed region. The tab is contacted by the dosing shoulder in use to limit extraction of the plunger from the barrel at each angular position so as to regulate a content ejectable from the barrel.

In accordance with other embodiments, the content resides within the barrel prior to ejection from the dosing syringe.

In accordance with other embodiments, the tab is rotationally fixable in use at each angular position via releasably lockable engagement between a pair of interlock portions.

In accordance with other embodiments, one interlock portion is on the detent ring and other interlock portion is on the endcap.

In accordance with other embodiments, the endcap includes an end wall interposed between a collar and a side wall, the other interlock portion is disposed along the collar, and the side wall engages the barrel.

In accordance with other embodiments, the detent ring includes a cylindrical portion extending from a ring portion, the one interlock portion is disposed along the cylindrical portion, and the cylindrical portion is disposed about the collar. In accordance with other embodiments, one interlock portion is a tooth and other interlock portion is a notch.

In accordance with other embodiments, the notch is formed between two other teeth.

In accordance with other embodiments, the detent ring is disposed about a collar extending from the endcap, the detent ring is releasably lockable to the collar via a pair of interlock portions, one interlock portion inwardly extends from the detent ring, and other interlock portion outwardly extends from the collar.

In accordance with other embodiments, the detent ring is disposed about a collar extending from the endcap, the detent ring is releasably lockable to the endcap via a pair of interlock portions, one interlock portion on the detent ring, and other interlock portion on the endcap.

In accordance with other embodiments, the plunger is axially movable along the alignment shoulder via sliding engagement between the alignment shoulder and a slot of the endcap.

In accordance with other embodiments, the barrel includes a barrel wall with a hub at a distal end and a barrel flange at the proximal end, the content is ejectable through the hub, and the endcap is secured to the barrel flange at the proximal end.

In accordance with other embodiments, the detent ring includes a cylindrical portion extending from a ring portion and the tab extends from the ring portion.

Several advantages are offered by one or more embodiments of the disclosure. The disclosure minimizes the number of components of the dose selector which in turn reduces manufacturing and assembly costs. The disclosure simplifies function of the dose selector which in turn increases reliability and minimizes errors in use. The disclosure is adaptable to single-use syringes, extemally-fillable syringes, and prefilled syringes. The disclosure is adaptable to multi-use syringes wherein a fluid is dispensed via two or more uses. The disclosure is adaptable to syringes storable in a sealed configuration for reuse. The disclosure is applicable to a variety of medical uses and non-medical uses.

The above and other objectives, features, and advantages of the present disclosure will become better understood from the following description, appended claims, and accompanying drawings, in which like reference numerals designate the same or similar elements. 4. Brief Description of the Drawings

Additional aspects, features, and advantages of the disclosure will be understood and will become more readily apparent when the disclosure is considered in light of the following description made in conjunction with the accompanying drawings:

FIG. 1 is a perspective view illustrating a dosing syringe including a barrel, a dose selector at one end of the barrel, and a plunger extendable and retractable with respect to the barrel and the dose selector in accordance with an embodiment of the disclosure;

FIG. 2a is a cross-section view illustrating a dosing syringe including a barrel, a dose selector, and a plunger wherein a content ejectable from the syringe originates from a source external to the syringe in accordance with an embodiment of the disclosure;

FIG. 2b is a cross-section view illustrating a dosing syringe including a barrel, a dose selector, and a plunger wherein a content ejectable from the syringe originates within the plunger and the content is communicated into the barrel prior to ejection in accordance with an embodiment of the disclosure;

FIG. 3 is an exploded view illustrating a dosing syringe including a barrel, a dose selector, and a plunger wherein the dose selector includes a first ring, a second ring, a detent ring, and an endcap in accordance with an embodiment of the disclosure;

FIG. 4 is a perspective, cross-section view illustrating a dose selector disposed about a plunger at one end of a barrel wherein the dose selector is secured to a flange extending from the barrel, the plunger is slidably disposed so as to be axially movable with respect to the barrel and components of the dose selector, and the plunger is slidably disposed so as to be rotatably movable with respect to the barrel and components of the dose selector except for a detent ring which rotates with the plunger in accordance with an embodiment of the disclosure;

FIG. 5 is an enlarged, cross-section view illustrating a dose selector wherein a detent ring of the dose selector rotates with a plunger so that one interlock portion engages one of a plurality of other interlock portions at engagement between the detent ring and an endcap of the dose selector in accordance within an embodiment of the disclosure; FIG. 6a is an enlarged, cross-section view illustrating a dose selector including an endcap, a detent ring, a second ring, and a first ring wherein one interlock portion engages another interlock portion at an interface between the detent ring and an end wall of the endcap in accordance with an embodiment of the invention;

FIG. 6b is an enlarged, cross-section view illustrating a dose selector including an endcap, a detent ring, a second ring, and a first ring wherein one interlock portion engages another interlock portion at an interface between the detent ring and the second ring in accordance with an embodiment of the invention;

FIG. 6c is an enlarged, cross-section view illustrating a dose selector including an endcap, a detent ring, and either a second ring or a first ring wherein one interlock portion engages another interlock portion at an interface between the detent ring and a side wall of the endcap in accordance with an embodiment of the invention;

FIG. 6d is an enlarged, cross-section view illustrating a dose selector including an endcap, a detent ring, and either a second ring or a first ring wherein one interlock portion engages another interlock portion at an interface between the detent ring and one of the first ring or the second ring in accordance with an embodiment of the invention;

FIG. 6e is an enlarged, cross-section view illustrating a dose selector including an endcap and a detent ring wherein one interlock portion engages another interlock portion at an interface between the detent ring and a barrel flange extending at a proximal end of a barrel in accordance with an embodiment of the invention;

FIG. 7 is a perspective view illustrating a detent ring disposed about a plunger wherein a recessed region is bounded by a dosing shoulder and an alignment shoulder, the plunger is axially movable with respect to the detent ring along the alignment shoulder, and the detent ring is rotatably movable with the plunger in accordance with an embodiment of the disclosure;

FIG. 8 is a perspective with cross-section view illustrating engagement between a slot along a detent ring and an alignment shoulder along a plunger in accordance with an embodiment of the disclosure;

FIG. 9 is a perspective view with partial cross-section and transparency views illustrating features of an endcap and a plunger wherein a plurality of interlock portions are disposed along an end wall of the endcap, a tab extends inward from an inner surface of a collar of the endcap, and a recessed region defined between an alignment shoulder and a dosing shoulder along the plunger is rotatably movable with respect to the tab in accordance with an embodiment of the disclosure;

FIG. 10a is a diagram illustrating an axial path corresponding to the maximum extension between a plunger and a barrel at two angular positions selectable via rotation of the plunger in accordance with an embodiment of the disclosure;

FIG. 10b is an end view illustrating angular positions relative to a plunger flange which correspond to the rotational adjustment to a plunger and a recessed region thereon with respect to a tab extending inward from an endcap of a dose selector in accordance with an embodiment of the disclosure;

FIG. 1 la is a perspective view illustrating relative position between a plunger and an endcap when the plunger is at an angular position corresponding to a lesser extension/retraction of the plunger from a barrel in accordance with an embodiment of the disclosure;

FIG. 1 lb is a perspective view illustrating relative position between a plunger and an endcap when the plunger is at an angular position corresponding to a greater extension/retraction of the plunger from a barrel in accordance with an embodiment of the disclosure;

FIG. 12 is a cross-section view illustrating a dose selector including an endcap and a detent ring wherein the endcap is interposed between the detent ring and a barrel flange extending outward from a barrel and the detent ring rotatably engages the endcap in accordance with an embodiment of the invention;

FIG. 13a is a distal perspective view illustrating features of an endcap and a plunger wherein a slot of the endcap and an alignment shoulder of the plunger slidably engage so that a recessed region defined between an alignment shoulder and a dosing shoulder along the plunger is axially movable with respect to the endcap in accordance with an embodiment of the disclosure;

FIG. 13b is a proximal perspective view illustrating features of an endcap and a plunger wherein a slot of the endcap and an alignment shoulder of the plunger slidably engage, a recessed region defined between an alignment shoulder and a dosing shoulder along the plunger is axially movable with respect to the endcap, and a plurality of interlock portions extend outward from a collar of the endcap in accordance with an embodiment of the disclosure; FIG. 14a is a perspective view illustrating features of a dose selector and a plunger wherein a detent ring of the dose selector rotatably engages an endcap of the dose selector, a tab extends from the detent ring into a recessed region along the plunger between an alignment shoulder and a dosing shoulder, and the plunger is axially movable with respect to the endcap, the detent ring, and the tab in accordance with an embodiment of the disclosure;

FIG. 14b is an enlarged perspective view illustrating a detent ring with an interlock portion extending inward therefrom and an endcap with another interlock portion extending outward therefrom wherein the teeth of the interlock portions are interdigitated and releasably lockable in accordance with an embodiment of the disclosure;

FIG. 15a is a diagram illustrating an axial path corresponding to the maximum extension between a plunger and a barrel at two angular positions selectable via rotation of a detent ring in accordance with an embodiment of the disclosure; and

FIG. 15b is an end view illustrating angular positions of a detent ring which correspond to the rotational adjustment to a tab extending inward from the detent ring with respect to a recessed region along an outer surface of a plunger in accordance with an embodiment of the disclosure.

5. Modes for Carrying Out the Disclosure

Reference will now be made in detail to several embodiments of the disclosure that are illustrated in the accompanying drawings. Wherever possible, same or similar reference numerals are used in the drawings and the description to refer to the same or like parts.

While features of various embodiments are separately described herein, it is understood that such features may be combinable to support other additional embodiments.

Components described herein may be composed of one or more suitable materials.

Components described herein may be manufactured via methods, processes, and techniques understood in the art, including, but not limited to, machining, molding, forming, or three-dimensional printing. The drawing figures are not necessarily drawn to scale, but instead are drawn to provide a better understanding of the components thereof, and are not intended to be limiting in scope, but to provide exemplary illustrations.

Referring now to FIG. 1, a dosing syringe 1 in its simplest form includes a barrel 2, a plunger 3, and a dose selector 4. The plunger 3 and the dose selector 4 are arranged at one end of the barrel 2. The dose selector 4 is secured to the barrel 2 so that the dose selector 4 is disposed about the plunger 3. The barrel 2 and the plunger 3 are telescopically arranged so that the plunger 3 is both slidingly-extendable outward and slidingly-retractable inward with respect to the barrel 2 and the dose selector 4. Matter is drawn into the barrel 2 as the plunger 3 is extended from the barrel 2. Matter is ejected from the barrel 2 as the plunger 3 is retracted into the barrel 2.

Referring now to FIGS. 2a, 2b, and 3, preferred embodiments of the barrel 2 include a barrel wall 6 interposed between a hub 5 at one end and a barrel flange 7 at another end. The barrel wall 6 defines a cavity, preferably cylindrically shaped, within the barrel 2 which is capable of containing a content 13 prior to ejection. The hub 5 is adapted at a distal end 33 of the barrel 2 to receive a needle 11 through which a content 13 either enters or exits the cavity formed by the barrel wall 6. The barrel flange 7 is adapted to facilitate use of the dosing syringe 1 so that a user may extend or retract the plunger 3.

Referring now to FIGS. 2a and 2b, preferred embodiments of the plunger 3 include a shaft 9 interposed between a piston 8 at one end and a plunger flange 10 at another end. The shaft 9 is adapted to inwardly and outwardly move with respect to the barrel wall 6 so as to cooperatively decrease or increase, respectively, the fillable volume within the cavity occupied by a content 13. The piston 8 is adapted to slidingly engage the barrel wall 6 so as to facilitate retraction of a content 13 into the dosing syringe 1 and ejection of a content 13 from the dosing syringe 1. The plunger flange 10 is adapted to facilitate use of the dosing syringe 1 so that a user may extend and retract the plunger 3. The dose selector 4 is secured adjacent to the barrel flange 7 so as to not impede functional aspects of the barrel 2, the plunger 3, and components of each.

Referring now to FIG. 2a, the dosing syringe 1 in some embodiments may be adapted to receive a content 13 from an external source. In one non-limiting example, a content 13 may initially reside within a vial 12 external to the dosing syringe 1 whereby the content 13 is transferred in use via the needle 11 into the barrel 2 from the vial 12 as the plunger 3 is extended from the barrel 2. In another non-limiting example, the barrel 2 may be prefilled with a content 13 from an external source prior to packaging.

Referring now to FIG. 2b, the dosing syringe 1 in some embodiments may be adapted to receive a content 13 from an internal source. In one non-limiting example, the content 13 may initially reside within the dosing syringe 1 so as to be transferable from the plunger 3 to the barrel 2 as the plunger 3 is extracted from the barrel 2. In these embodiments, the shaft 9 has a plunger wall 14 which defines a cavity, preferably cylindrically shaped, within the plunger 3 which is capable of containing a content 13 prior to ejection. The content 13 may be transferred from the plunger 3 to the barrel 2 either via or through the piston 8; however, it is understood that other transfer means known within the art are also applicable to the disclosure. Several nonlimiting examples of syringe-based transfer mechanisms are described by Kolonia et al. in U.S. Patent Nos. 9,850,058, 10,450,124, and 10,800,597, each entitled Telescoping Syringe with One-Way Valve.

Referring now to FIG. 3, the barrel 2 and components of the dose selector 4 at a proximal end 32 of the barrel 2 are sized and shaped so as to receive the plunger 3. The dose selector 4 may include a first ring 15, a second ring 16, a detent ring 17, and an endcap 18. It is understood that the first ring 15 and/or the second ring 16 may be optional components of embodiments, preferred or otherwise, of the dosing syringe 1. The first ring 15 may be in the form of a sealing ring, a gasket, a spring, or other functionally suitable component. The second ring 16 may be in the form of a washer or other functionally suitable component. The detent ring 17 includes one or more features which releasably impede motion with at least one of the endcap 18, the first ring 15, the second ring 16, or the barrel 2, the latter preferably at the barrel flange 7. The endcap 18 is sized and shaped so as to receive the first ring 15, the second ring 16, and the detent ring 17 in some embodiments, or the first ring 15 and the detent ring 17 in other embodiments, or the second ring 16 and the detent ring 17 in yet other embodiments, or the detent ring 17 only in still other embodiments.

Referring now to FIG. 4, the endcap 18 of the dose selector 4, in preferred embodiments, includes an end wall 19 interposed between a collar 34 and a side wall 20 wherein the collar 34 is smaller diameter-wise than the side wall 20. The side wall 20 may be secured via one or more flanges 21, or other suitable means, to the barrel flange 7 at the proximal end 32 of the barrel 2. The first ring 15, the second ring 16, and the detent ring 17 are interposed between the barrel flange 7 and the end wall 19 whereby cooperation between the barrel flange 7, the side wall 20, and the end wall 19 encloses the first ring 15, the second ring 16, and the detent ring 17. In other embodiments, the barrel flange 7, the side wall 20, and the end wall 19 cooperate to enclose the first ring 15 and the detent ring 17 or the second ring 16 and the detent ring 17 as in FIGS. 6c and 6d. In yet other embodiments, the barrel flange 7, the side wall 20, and the end wall 19 cooperate to enclose the detent ring 17 as in FIG. 6e. The plunger 3, and specifically the shaft 9, is axially movable with respect to the barrel wall 6, the barrel flange 7, the first ring 15, the second ring 16, the detent ring 17, and the endcap 18. The plunger 3, and specifically the outer surface of the shaft 9, may slidingly contact at least one of the first ring 15, the second ring 16, the detent ring 17, or the collar 34.

Referring now to FIGS. 5, 6a, and 6b, the first ring 15 is interposed between the barrel 2, preferably the barrel flange 7 at the proximal end 32, and the second ring 16 within the dose selector 4. The first ring 15 may sealingly engage at least one of the barrel 2, the plunger 3 at the shaft 9, or the second ring 16. In preferred embodiments, the first ring 15 communicates a biasing force F onto the second ring 16 which biasingly urges the detent ring 17 into contact with the end wall 19 of the endcap 18. In some embodiments, the biasing force F may result by compressing a first ring 15 composed of a resilient material, one non-limiting example being rubber, between the barrel flange 7 and the second ring 16. In other embodiments, the biasing force F may result when the first ring 15 is a compression spring or other spring or spring-like element which prefers expansion rather than contraction.

Referring again to FIGS. 5, 6a, and 6b, the second ring 16 is interposed between the first ring 15 and the detent ring 17. The second ring 16 is preferably a washer or the like which permits the detent ring 17 to slidingly rotate with respect to the second ring 16 and/or the first ring 15.

Referring again to FIGS. 5, 6a, and 6b, the detent ring 17 is interposed between the second ring 16 and the end wall 19 of the endcap 18. In some embodiments, the detent ring 17 may include a cylindrical portion 36 which extends from a ring portion 37. The cylindrical portion 36 may be arranged so as to reside between the endcap 18 and the plunger 3, the latter preferably along the shaft 9. The detent ring 17 engages the plunger 3 so as to be rotatably movable therewith. The plunger 3 is axially movable with respect to the barrel flange 7, the first ring 15, the second ring 16, the detent ring 17, and the endcap 18. The plunger 3 is translated by grasping the plunger 3 with one hand, grasping the barrel 2 with another hand, and applying a translational force via one hand relative to the other hand. The detent ring 17 lockingly and releasably engages the end wall 19. In one non-limiting example, at least one first interlock portion 22 may lockingly and releasably engage at least one second interlock portion 23 along an interface 38. The interface 38 may be between the detent ring 17 and the end wall 19 as in FIGS. 5 and 6a, or between the detent ring 17 and the second ring 16 as in FIG. 6b, or between the detent ring 17 and the side wall 20 as in FIG. 6c, or between the detent ring 17 and the first ring 15 or the second ring 16 as in FIG. 6d, or between the detent ring 17 and the barrel flange 7 as in FIG. 6e. In some embodiments, the first interlock portion(s) 22 may reside along the detent ring 17 as illustrated by way of the non-limiting example in FIG. 5. In other embodiments, the second interlock portion(s) 23 may reside along the detent ring 17 as illustrated by way of non-limiting example in FIG. 6a. In preferred embodiments, either the first interlock portion(s) 22 or the second interlock portion(s) 23 reside(s) along the ring portion 37. The first and second interlock portions 22, 23 may be in the form of a ball and socket arrangement. However, it is understood that other suitable shapes, engagements, and/or configurations are likewise applicable.

Referring now to FIGS. 5, 6a, 6b, 6c, 6d, and 6e, a first interlock portion 22 in use moves from one second interlock portion 23 to the next second interlock portion 23 within the dose selector 4 as the detent ring 17 is rotated via the plunger 3. The detent ring 17 is rotated by grasping the plunger 3 with one hand, grasping the barrel 2 with another hand, and applying a rotational force onto the plunger 3 via one hand relative to the other hand. The first interlock portion 22 slidingly moves between adjacent second interlock portions 23 along the surface containing the second interlock portions 23. The first interlock portion 22 is lockingly engaged to a second interlock portion 23 when the first interlock portion 22 is properly aligned with the second interlock portion 23. The locking engagement is releasable so that the first interlock portion 22 and the second interlock portion 23 are separable, preferably slidingly. The locking engagement is released by applying a rotational force to the detent ring 17 via the plunger 3 wherein the rotational force is of sufficient magnitude to induce relative motion between the first interlock portion 22 and the second interlock portion 23 which causes the first interlock portion 22 and the second interlock portion 23 to disengage. The releasably locking engagement between a first interlock portion 22 and a second interlock portion 23 corresponds to an angular position relative between the plunger 3 and the dose selector 4, and also to the angular offset between features of the plunger 3 and the dose selector 4 which enable dosing function.

Referring now to FIGS. 6a, 6b, 6c, 6d, and 6e, one or more of the first ring 15, the second ring 16, or detent ring 17 in the various embodiments of the dose selector 4 either may or may not extend into contact with the inner diameter surface of the side wall 20. In preferred embodiments, it is understood that the detent ring 17 and the component contacted at the interface 38 permit for relative motion therebetween so as to allow lock and release functionalities between the first interlock portion(s) 22 and the second interlock portions(s) 23.

Referring now to FIGS. 6c and 6d, either the first ring 15 or the second ring 16, in other embodiments, is interposed between the barrel 2, preferably the barrel flange 7, and the detent ring 17 within the dose selector 4. The plunger 3 (not shown) is axially movable with respect to the barrel flange 7, either the first ring 15 or the second ring 16, the detent ring 17, and the endcap 18. The detent ring 17 is lockingly and releasably engageable as described elsewhere herein.

Referring again to FIGS. 6c and 6d, the first ring 15 may sealingly engage at least one of the barrel flange 7, the plunger 3 and preferably the shaft 9 (not shown), or the detent ring 17. In preferred embodiments, the first ring 15 communicates a biasing force F, as in FIG. 5, onto the detent ring 17 which biasingly urges the detent ring 17 into contact with the end wall 19 of the endcap 18. In some embodiments, the biasing force F may result by compressing a first ring 15 composed of a resilient material, one non-limiting example being rubber, between the barrel flange 7 and the detent ring 17. In other embodiments, the biasing force F may result when the first ring 15 is a compression spring or other spring or spring-like element which prefers expansion rather than contraction. The detent ring 17 is interposed between the first ring 15 and the end wall 19.

Referring again to FIGS. 6c and 6d, the second ring 16 may be interposed between the barrel flange 7 and the detent ring 17. The second ring 16 is preferably a washer or the like which permits the detent ring 17 to slidingly rotate with respect to the second ring 16 and/or the barrel 2, preferably via the barrel flange 7. The detent ring 17 is interposed between the second ring 16 and the end wall 19. The detent ring 17 engages the plunger 3 so as to be rotatably movable therewith.

Referring now to FIG. 6e, the detent ring 17, in yet other embodiments, is interposed between the barrel 2, preferably the barrel flange 7, and the endcap 18 within the dose selector 4. The detent ring 17 contacts the end wall 19 of the endcap 18. The detent ring 17 engages the plunger 3 (not shown) so as to be rotatably movable therewith. The plunger 3 is axially movable with respect to the barrel flange 7, the detent ring 17, and the endcap 18. The detent ring 17 is lockingly and releasably engageable as described elsewhere herein.

Referring now to FIGS. 7 and 8, the plunger 3 further includes one or more recessed regions 26 which separately extend into an outer surface 29 of the plunger 3, and preferably at the shaft 9, so as to reside along the exterior thereof. Each recessed region 26 is bounded at least in part by an alignment shoulder 24 and a dosing shoulder 25. The alignment shoulder 24 and the dosing shoulder 25 are each broadly understood to be a feature which restricts and/or impedes movement of the plunger 3 with respect to the dose selector 4 attached to the barrel 2. In one non-limiting example, either the alignment shoulder 24 or the dosing shoulder 25 may be in the form of a mechanical stop or the like. In another non-limiting example, either the alignment shoulder 24 or the dosing shoulder 25 may be defined by a discontinuity. In another non-limiting example, either the alignment shoulder 24 or the dosing shoulder 25 may be defined by a change in the depth of the recessed region 26 with respect to the outer surface 29. In another non-limiting example, either the alignment shoulder 24 or the dosing shoulder 25 may be defined by an outwardly extending feature with respect to the outer surface 29. In another non-limiting example, either the alignment shoulder 24 or the dosing shoulder 25 may be defined by a change in the cross- sectional thickness of the plunger 3. Regardless, the alignment shoulder 24 and the dosing shoulder 25 define the boundaries of movement relative by and between the recessed region 26 and a tab 28 which in turn limit rotation and/or translation between the plunger 3 and the barrel 2.

Referring again to FIGS. 7 and 8, the alignment shoulder 24 engages a slot 27 along the inner diameter of the detent ring 17. In preferred embodiments, the engagement rotationally locks the detent ring 17 to the plunger 3 so that the detent ring 17 is rotatable with the plunger 3 and thereby rotatable with respect to other components of the dose selector 4. The engagement is also preferred to permit the plunger 3 to axially move along the alignment shoulder 24 with respect to the detent ring 17. The alignment shoulder 24 is preferably aligned along the length of the plunger 3. In some embodiments, the alignment shoulder 24 is arranged, for example parallel relative to the axial length of the plunger 3, so that sliding motion between the alignment shoulder 24 and the slot 27 causes the plunger 3 to move axially only with respect to the dose selector 4. In other embodiments, the alignment shoulder 24 is arranged, for example non-parallel relative to the axial length of the plunger 3, so that sliding motion between the alignment shoulder 24 and the slot 27 causes the plunger 3 to move both axially and rotationally with respect to the dose selector 4.

Referring again to FIGS. 7 and 8, the dosing shoulder 25 is arranged along the outer surface 29 so as to be engageable with the tab 28. The dosing shoulder 25 is aligned preferably non-parallel to the axial length of the plunger 3. The dosing shoulder 25 may straightly and/or curvedly extend along the plunger 3 whereby the dosing shoulder 25 is formed by at least one segment. It is preferable for the dosing shoulder 25 to be disposed at an angle with respect to the alignment shoulder 24 whereby the distance between the dosing shoulder 25 and the alignment shoulder 24, and therefore the corresponding width of the recessed region 26, decreases with axial distance from the plunger flange 10. In preferred embodiments, the width of the recessed region 26 adjacent the distal end 33 may be at least as wide as the tab 28. Other angular orientations between the dosing shoulder 25 and the alignment shoulder 24 are possible. Furthermore, other varying and non-varying width profiles are possible for the recessed region 26 as defined by the dosing shoulder 25 and the alignment shoulder 24.

Referring now to FIGS. 9 and 4, the endcap 18 may be securable to the barrel 2, and preferably the barrel flange 7, via mechanical or non-mechanical means. In one non-limiting example, the endcap 18 may include at least one flange 21, as in FIGS. 6a-6e, which facilitate mechanical locking between the endcap 18 and the barrel 2. In other non-limiting examples, the endcap 18 may be non-mechanically secured to the barrel 2 via an adhesive, an ultrasonic weld, or other suitable means. Referring now to FIGS. 9, 6a, 6b, 6c, 6d, and 6e, the first interlock portion(s) 22 or the second interlock portions 23 may be arranged along the end wall 19 of the endcap 18 so as to be engageable with the corresponding second interlock portions 23 or the corresponding first interlock portion(s) 22. In preferred embodiments, the first interlock portions 22 or the second interlock portions 23 are arranged in a circular pattern along the end wall 19 about the plunger 3, and preferably the shaft 9, or along one of the side wall 20, the detent ring 17, the second ring 16, the first ring 15, or the barrel flange 7 at the interface 38.

Referring now to FIG. 9, the tab 28 inwardly extends from an inner surface of the endcap 18, preferably at the collar 34. This arrangement positions the tab 28 within the recessed region 26 so as to be contactable with the alignment shoulder 24 and the dosing shoulder 25. The tab 28 may or may not contact the plunger 3, preferably the shaft 9, within the recessed region 26; however, the tab 28 contacts the dosing shoulder 25 in use and the tab 28 may or may not contact the alignment shoulder 24 in use. The various arrangements also permit the plunger 3 to be rotatable with respect to the endcap 18 over a range of angular rotations bounded by the alignment shoulder 24 and the dosing shoulder 25. One end of the range is determined by contact between the tab 28 and the alignment shoulder 24. Another end of the range is determined by contact between the tab 28 and the dosing shoulder 25. In some alternate embodiments, the tab 28 may inwardly extend from the barrel 2.

Referring now to FIGS. 10a, 10b, and 1, the recessed region 26 along the outer surface 29 and the tab 28 are graphically illustrated in simplified form to describe functional aspects of the dosing syringe 1. The locations of the tab 28 are shown relative to positions within the recessed region 26 so as to correspond to extension between the plunger 3 and the barrel 2 in use wherein the graphical representation shows the barrel 2 translating relative to the plunger 3 and the plunger 3 rotating relative to the barrel 2.

Referring now to FIGS. 10a, 10b, 1, and 4, the plunger 3 and the barrel 2 are relatively rotatable so as to position the alignment shoulder 24 and the dosing shoulder 25 of the recessed region 26 with respect to the tab 28 within the dose selector 4. The dosing syringe 1 may permit for two or more angular positions 0 between the plunger 3 and the barrel 2 which correspond to an equal number of angular positions 9 between the recessed region 26 and the tab 28. In a non-limiting example, the detent ring 17 is rotated via the plunger 3 with respect to the barrel 2 and other components of the dose selector 4 so as to reposition the dosing shoulder 25 with respect to the tab 28. The plunger 3 is fixed with respect to the barrel 2 and the dose selector 4 at each angular position 9 via locking engagement between at least one first interlock portion 22 and at least one second interlock portion 23. This functionality allows the user to adjust the axial path X over which the barrel 2 or the plunger 3 is axially movable outward via adjustment to the intersect position 31 at which the dosing shoulder 25 and the tab 28 contact. The axial path X is either increased or decreased via adjustments to the angular position 9 so that the axial path Xi is shorter at one angular position 9i corresponding to a shorter extension of the plunger 3 as in FIG. I la with lesser ejectable content 13 within the barrel 2 or so that the axial path X2 is longer at another angular position 92 corresponding to a longer extension of the plunger 3 as in FIG. 1 lb with greater ejectable content 13 within the barrel 2. The end result is a detent ring 17 which rotationally cooperates with an endcap 18 so that a plunger 3 axially cooperates with the endcap 18 at each angular position 9 to quantitatively regulate a content 13 ejectable from the barrel 2.

Referring now to FIGS. 19a, 19b, and 9, the adjustment fidelity with respect to the incremental increase or decrease of the quantity of content 13 ejectable at each angular position 9 is based in part on the shape of the dosing shoulder 25 and location of the dosing shoulder 25 with respect to the tab 28. Furthermore, the adjustment fidelity is determined at least in part by the number of first interlock portions 22, the number of second interlock portions 23, the spacing between first interlock portions 22, and/or the spacing between second interlock portions 23 within the dose selector 4.

Referring now to FIGS. 19a, I la, and 1 lb, the recessed region 26 may be bounded by a stop 35 or the like adjacent to the plunger flange 19. In preferred embodiments, the stop 35 corresponds to the limit at which the plunger 3 is initially movable from the barrel 2 and at which the plunger 3 stops moving into the barrel 2. The stop 35 may be in a form of a mechanical stop, a functionally suitable structure, or other structure described elsewhere herein for either the alignment shoulder 24 or the dosing shoulder 25. The plunger 3 is axially movable between the stop position 39 at which the proximal edge 39 of the tab 28 contacts the stop 35 and the intersect position 31 at which the distal edge 49 of the tab 28 contacts the dosing shoulder 25. In preferred embodiments, the axial path X is the distance between the stop position 30 and the intersect position 31 less the offset L which corresponds to the distance between the proximal edge 39 and the distal edge 40. The axial path X correlates to the quantity of content 13 entering/exiting or exiting the dosing syringe 1 in use.

Referring now to FIG. 12, the dosing syringe 1, in other embodiments, includes an endcap 18 of the dose selector 4 interposed between a barrel 2 and a detent ring 17 of the dose selector 4. The endcap 18 further includes an end wall 19 interposed between a collar 34 and a side wall 20 wherein the collar 34 is smaller diameter-wise than the side wall 20. In some embodiments, the side wall 20 may be secured via one or more flanges 21, or other suitable means, to a barrel flange 7 at the proximal end 32 of the barrel 2. In other non-limiting examples, the endcap 18 may be non-mechanically secured to the barrel 2 via an adhesive, an ultrasonic weld, or other suitable means. In yet other embodiments, the side wall 20 may be either formed directly onto or a part of the barrel flange 7 so that the endcap 18 is integral with the barrel 2. The plunger 3 is slidingly extendable and retractable with respect to the barrel 2 and the dose selector 4. This arrangement permits the plunger 3 to be axially movable with respect to the barrel 2, the endcap 18, and the detent ring 17. Two or more of the barrel flange 7, the side wall 20, the end wall 19, the collar 34, the barrel 2, and/or the plunger 3 may sealingly cooperate at the proximal end 32.

Referring again to FIG. 12, the detent ring 17 may include a cylindrical portion 36 which extends from a side of a ring portion 37. The ring portion 37 may abut the collar 34 so that the collar 34 is interposed between the ring portion 37 and the end wall 19. The cylindrical portion 36 may be disposed about the collar 34 so that the collar 34 is interposed between the plunger 3 and the cylindrical portion 36. One or more flanges 42 may inwardly extend from the cylindrical portion 36 so as to mechanically lock to a shoulder 43 of the collar 34.

Referring now to FIGS. 13a and 13b, the plunger 3 further includes at least one recessed region 26 which separately extend into the plunger 3, or preferably at the shaft 9 (not shown), so as to reside along the exterior thereof. Each recessed region 26 is bounded at least in part by an alignment shoulder 24 and a dosing shoulder 25. The alignment shoulder 24 and the dosing shoulder 25 are each broadly understood to be a feature which restricts and/or impedes movement of the plunger 3 with respect to the dose selector 4 as described elsewhere herein. It is understood that the alignment shoulder 24 and the dosing shoulder 25 define the boundaries of movement relative between the recessed region 26 and a tab 28, the latter shown in FIG. 14a, which in turn limit translation between the barrel 2 and the plunger 3 and rotation between the detent ring 17 and the plunger 3.

Referring again to FIGS. 13a and 13b, the alignment shoulder 24 engages a slot 27 along an opening 41 of the endcap 18. In preferred embodiments, the engagement locks the endcap 18 and the plunger 3 thereby precluding relative rotation therebetween. However, the engagement is also preferred to permit the plunger 3 to axially move with respect to the endcap 18. The alignment shoulder 24 is preferably aligned along the length of the plunger 3. In some embodiments, the alignment shoulder 24 is arranged, for example parallel relative to the axial length of the plunger 3, so that sliding motion between the alignment shoulder 24 and the slot 27 causes the plunger 3 to axially move only with respect to the endcap 18 and the dose selector 4. In other embodiments, the alignment shoulder 24 is arranged, for example nonparallel relative to the axial length of the plunger 3, so that sliding motion between the alignment shoulder 24 and the slot 27 causes the plunger 3 to move both axially and rotationally with respect to the endcap 18 and the dose selector 4. The endcap 18 may further include one or more second interlock portions 23 which outwardly extend therefrom, preferably at the collar 34. In preferred embodiments, the second interlock portion(s) 23 are located along the outer surface of the collar 34 at one side of the end wall 19.

Referring now to FIG. 14a, the tab 28 inwardly extends from the detent ring 17. In preferred embodiments, the tab 28 extends from an inner surface of the ring portion 37. Preferred arrangements position the tab 28 within the recessed region 26 so as to be contactable with the alignment shoulder 24 and the dosing shoulder 25. The tab 28 may or may not contact the plunger 3 within the recessed region 26. The tab 28 is rotatable via the detent ring 17 over a range of angular rotations bounded by the alignment shoulder 24 and the dosing shoulder 25. One end of the range is determined by contact between the tab 28 and the alignment shoulder 24. Another end of the range is determined by contact between the tab 28 and the dosing shoulder 25. In some alternate embodiments, the plunger 3 is rotatable, the detent ring 17 rotates with the plunger 3, one non-limiting example being via engagement between a slot 27 and the alignment shoulder 24, and the tab 28 inwardly extends from the endcap 18 or the barrel 2.

Referring now to FIGS. 14a and 14b, the dosing shoulder 25 is arranged so as to be engageable with the tab 28. The dosing shoulder 25 is aligned preferably nonparallel with respect to the plunger 3. The dosing shoulder 25 may straightly and/or curvedly extend along the plunger 3 whereby the dosing shoulder 25 is formed by at least one segment. It is preferable for the dosing shoulder 25 to be disposed at an angle with respect to the alignment shoulder 24 whereby the distance between the dosing shoulder 25 and the alignment shoulder 24, and therefore the corresponding width of the recessed region 26, decreases with axial distance from the plunger flange 10. Other angular orientations between the dosing shoulder 25 and the alignment shoulder 24 are possible. Furthermore, other varying and non-varying width profiles are possible for the recessed region 26 as permitted by the dosing shoulder 25 and the alignment shoulder 24.

Referring again to FIGS. 14a and 14b, the detent ring 17 is rotatably movable with respect to the endcap 18, the barrel 2, and the plunger 3. The detent ring 17 is rotated by grasping the detent ring 17 with one hand, grasping the barrel 2 with another hand, and applying a rotational force onto the detent ring 17 via one hand relative to the other hand. The plunger 3 is axially movable with respect to the barrel 2, the detent ring 17, and the endcap 18. The plunger 3 is translated by grasping the plunger 3 with one hand, grasping the barrel 2 with another hand, and applying a translational force via one hand relative to the other hand. The detent ring 17 rotatingly, lockingly and releasably engages the endcap 18, preferably along collar 34. In one non-limiting example, at least one first interlock portion 22 may extend from the detent ring 17 so as to lockingly and releasably engage at least one second interlock portion 23 along the endcap 18. The first interlock portion 22 may extend from either the ring portion 37 or the cylindrical portion 36. The second interlock portion 23 may extend from either the collar 34 or the side wall 20. The first and second interlock portions 22, 23 may be interdigitated teeth 44 or may be formed by interdigitated teeth 44. In one non-limiting example, one interlock portion 22 or 23 may be a tooth 44 and another interlock portion 23 or 22 may be a notch 45 wherein the notch 45 is formed between two teeth 44. However, it is understood that other suitable shapes, configurations, and/or engagements are likewise applicable.

Referring again to FIGS. 14a and 14b, a first interlock portion 22 in use moves from one second interlock portion 23 to the next second interlock portion 23 as the detent ring 17 is rotated with respect to the endcap 18. The first interlock portion 22 slidingly moves between adjacent second interlock portions 23 along the surface containing the second interlock portions 23. The first interlock portion 22 is lockingly engaged to a second interlock portion 23 when the first interlock portion 22 is properly aligned with the second interlock portion 23. The locking engagement is releasable so that the first interlock portion 22 and the second interlock portion 23 are separable. The locking engagement is released by applying a rotational force to the detent ring 17 wherein the rotational force is of sufficient magnitude to induce relative motion between the first interlock portion 22 and the second interlock portion 23 which causes the first interlock portion 22 and the second interlock portion 23 to disengage. The releasably locking engagement between a first interlock portion 22 and a second interlock portion 23 corresponds to an angular position relative between the detent ring 17 and the endcap 18, and also to the angular offset between features of the plunger 3 and the dose selector 4 which enable dosing function.

Referring now to FIGS. 14b and 13b, the first interlock portion(s) 22 or the second interlock portions 23 may be arranged in a circular pattern. The number, arrangement, design, and/or function of the interlock portions 22, 23 may determine the resistance to rotation or other rotation property between the detent ring 17 and the endcap 18.

Referring now to FIGS. 15a, 15b, and 1, the recessed region 26 along the outer surface 29 of the plunger 3 and the tab 28 are graphically illustrated in simplified form to describe functional aspects of the dosing syringe 1. The locations of the tab 28 are shown relative to positions within the recessed region 26 so as to correspond to extension between the plunger 3 and the barrel 2 in use wherein the graphical representation shows the barrel 2 translating relative to the plunger 3 and the detent ring 17 rotating relative to the plunger 3.

Referring now to FIGS. 15a, 15b, 14a, and 14b, the detent ring 17 and the endcap 18 are relatively rotatable so as to position the tab 28 of the dose selector 4 with respect to the alignment shoulder 24 and the dosing shoulder 25 of the recessed region 26. The dosing syringe 1 may permit for two or more angular positions 9 between the detent ring 17 and the plunger 3 which correspond to an equal number of angular positions 9 between the tab 28 and the recessed region 26. In a non-limiting example, the detent ring 17 is rotated with respect to the barrel 2, the plunger 3, and other components of the dose selector 4 so as to reposition the tab 28 with respect to the dosing shoulder 25. The detent ring 17 is fixed with respect to the barrel 2 and the dose selector 4 at each angular position 9 via locking engagement between at least one first interlock portion 22 and at least one second interlock portion 23. This functionality allows the user to adjust the axial path X over which the barrel 2 or the plunger 3 is axially movable outward via adjustment to the intersect position 31 at which the dosing shoulder 25 and the tab 28 contact. The axial path X is either increased or decreased via adjustments to the angular position 9 so that the axial path Xi is longer at one angular position 9i corresponding to a longer extension of the plunger 3 as in FIG. 1 lb with greater ejectable content 13 within the barrel 2 or so that the axial path X2 is shorter at another angular position 92 corresponding to a shorter extension of the plunger 3 as in FIG. 1 la with lesser ejectable content 13 within the barrel 2. The end result is a detent ring 17 which rotationally cooperates with an endcap 18 so that a plunger 3 axially cooperates with the detent ring 17 at each angular position 9 to quantitatively regulate a content 13 ejectable from the barrel 2.

Referring now to FIGS. 15a, 15b, and 14b, the adjustment fidelity with respect to the incremental increase or decrease of the quantity of content 13 ejectable at each angular position 9 is based in part on the shape of the dosing shoulder 25 and location of the dosing shoulder 25 with respect to the tab 28. Further, the adjustment fidelity is determined at least in part by the number of first interlock portions 22, the number of second interlock portions 23, the spacing between first interlock portions 22, and/or the spacing between second interlock portions 23.

Referring now to FIGS. 15a, I la, and 1 lb, the recessed region 26 may be bounded by a stop 35 or the like adjacent to the plunger flange 19. In preferred embodiments, the stop 35 corresponds to the limit at which the plunger 3 is initially movable from the barrel 2 and at which the plunger 3 stops moving into the barrel 2. The stop 35 may be in a form of a mechanical stop, a functionally suitable structure, or other structure described elsewhere herein for either the alignment shoulder 24 or the dosing shoulder 25. The plunger 3 is axially movable between the stop position 39 at which the proximal edge 39 of the tab 28 contacts the stop 35 and the intersect position 31 at which the distal edge 49 of the tab 28 contacts the dosing shoulder 25. In preferred embodiments, the axial path X is the distance between the stop position 30 and the intersect position 31 less the offset L which corresponds to the distance between the proximal edge 39 and the distal edge 40. The axial path X correlates to the quantity of content 13 entering/exiting or exiting the dosing syringe 1 in use.

While the disclosure is susceptible to various modifications and alternative constructions, certain illustrative embodiments are shown in the drawings and are described in detail herein. It should be understood, however, there is no intention to limit the disclosure to the specific embodiments disclosed, but on the contrary, the intention is to cover all modifications, alternative constructions, combinations, and equivalents falling into the spirit and scope of the disclosure.

Claims

CLAIMS What is claimed is:

1. A dosing syringe comprising:

(a) a barrel;

(b) a dose selector at a proximal end of said barrel; and

(c) a plunger extendable and retractable with respect to said barrel; wherein: said dose selector comprises a detent ring and an endcap, said detent ring disposed within said endcap, said detent ring and said endcap disposed about said plunger, said detent ring rotatably movable via said plunger with respect to said endcap, said detent ring rotationally engages said endcap, said detent ring releasably lockable within said dose selector at at least two angular positions of said plunger with respect to said endcap, said plunger axially movable with respect to said detent ring and said endcap, said detent ring rotationally cooperates with said endcap so that said plunger axially cooperates with said endcap at each said angular position to quantitatively regulate a content ejectable from said barrel.

2. The dosing syringe of claim 1, wherein said content resides within said barrel prior to ejection from said dosing syringe.

3. The dosing syringe of claim 1, wherein said content enters said barrel in use of said dosing syringe.

4. The dosing syringe of claim 1, wherein said endcap includes a tab which extends into a recessed region disposed along an outer surface of said plunger, said recessed region being axially movable and rotationally movable via said plunger with respect to said tab.

5. The dosing syringe of claim 4, wherein said recessed region being bounded by a dosing shoulder and an alignment shoulder.

6. The dosing syringe of claim 5, wherein said tab being contacted by said dosing shoulder in use to limit extraction of said plunger from said barrel at each said angular position so as to regulate said content entering said barrel.

7. The dosing syringe of claim 6, wherein said endcap further comprises another said tab which extends into another said recessed region disposed along said outer surface of said plunger, said recessed regions separately disposed along said outer surface.

8. The dosing syringe of claim 5, wherein said detent ring being rotatably movable via said plunger by locking engagement between said alignment shoulder and a slot of said detent ring.

9. The dosing syringe of claim 5, wherein said plunger being axially movable along said alignment shoulder via sliding engagement between said alignment shoulder and a slot of said detent ring.

10. The dosing syringe of claim 1, wherein said dose selector further comprises a first ring interposed between said barrel and said detent ring.

11. The dosing syringe of claim 10, wherein said first ring sealingly engages at least one of said barrel, said plunger, or said detent ring.

12. The dosing syringe of claim 10, wherein said first ring being compressed between said barrel and said detent ring, said first ring biases said detent ring toward said endcap.

13. The dosing syringe of claim 10, wherein said first ring being a spring which biases said detent ring toward said endcap.

14. The dosing syringe of claim 10, wherein said detent ring being rotationally fixable in use at each said angular position via releasably lockable engagement between two interlock portions at an interface between said detent ring and said first ring.

15. The dosing syringe of claim 10, wherein said dose selector further comprises a second ring interposed between said first ring and said detent ring.

16. The dosing syringe of claim 15, wherein said first ring sealingly engages at least one of said barrel, said plunger, or said second ring.

17. The dosing syringe of claim 15, wherein said first ring being compressed between said barrel and said second ring, said first ring biases said second ring toward said detent ring, said second ring biases said detent ring toward said endcap.

18. The dosing syringe of claim 15, wherein said second ring being a washer, said detent ring being slidingly rotatable with respect to at least one of said second ring or said first ring.

19. The dosing syringe of claim 15, wherein said first ring being a spring which biases said second ring toward said detent ring and said detent ring toward said endcap.

20. The dosing syringe of claim 15, wherein said detent ring being rotationally fixable in use at each said angular position via releasably lockable engagement between two interlock portions at an interface between said detent ring and said second ring.

21. The dosing syringe of claim 1, wherein said dose selector further comprises a second ring interposed between said barrel and said detent ring.

22. The dosing syringe of claim 21, wherein said second ring being a washer, said detent ring being slidingly rotatable with respect to at least one of said second ring or said barrel.

23. The dosing syringe of claim 21, wherein said detent ring being rotationally fixable in use at each said angular position via releasably lockable engagement between two interlock portions at an interface between said detent ring and said second ring.

24. The dosing syringe of claim 1, wherein said barrel includes a barrel wall with a hub at a distal end and a barrel flange at said proximal end, said content being ejectable through said hub, said endcap being secured to said barrel flange at said proximal end.

25. The dosing syringe of claim 1, wherein said detent ring being rotationally fixable in use at each said angular position via releasably lockable engagement within said dose selector between two interlock portions.

26. The dosing syringe of claim 25, wherein said two interlock portions disposed at an interface between said detent ring and an end wall of said endcap.

27. The dosing syringe of claim 25, wherein said two interlock portions disposed at an interface between said detent ring and a side wall of said endcap.

28. The dosing syringe of claim 25, wherein said two interlock portions disposed at an interface between said detent ring and a barrel flange at said proximal end.

29. The dosing syringe of claim 25, wherein one said interlock portion being a ball and other said interlock portion being a socket.

30. A dosing syringe comprising:

(a) a barrel;

(b) a dose selector at a proximal end of said barrel; and

(c) a plunger extendable and retractable with respect to said barrel; wherein: said dose selector comprises an endcap and a detent ring, said endcap interposed between said barrel and said detent ring, said detent ring rotatably engages said endcap, said detent ring includes a tab which extends into a recessed region disposed along an outer surface of said plunger, said recessed region being bounded by a dosing shoulder and an alignment shoulder, said recessed region being axially movable via said plunger with respect to said tab, said tab being rotationally movable via said detent ring with respect to said recessed region, said tab being releasably lockable at at least two angular positions with respect to said recessed region, said tab being contacted by said dosing shoulder in use to limit extraction of said plunger from said barrel at each said angular position so as to regulate a content ejectable from said barrel.

31. The dosing syringe of claim 30, wherein said content resides within said barrel prior to ejection from said dosing syringe.

32. The dosing syringe of claim 30, wherein said content enters said barrel in use of said dosing syringe.

33. The dosing syringe of claim 30, wherein said tab being rotationally fixable in use at each said angular position via releasably lockable engagement between a pair of interlock portions.

34. The dosing syringe of claim 33, wherein one said interlock portion being on said detent ring and other said interlock portion being on said endcap.

35. The dosing syringe of claim 34, wherein said endcap includes an end wall interposed between a collar and a side wall, said other said interlock portion disposed along said collar, said side wall engages said barrel.

36. The dosing syringe of claim 35, wherein said detent ring includes a cylindrical portion extending from a ring portion, said one said interlock portion disposed along said cylindrical portion, said cylindrical portion disposed about said collar.

37. The dosing syringe of claim 33, wherein one said interlock portion being a tooth and other said interlock portion being a notch.

38. The dosing syringe of claim 37, wherein said notch formed between two other said teeth.

39. The dosing syringe of claim 30, wherein said detent ring being disposed about a collar extending from said endcap, said detent ring being releasably lockable to said collar via a pair of interlock portions, one said interlock portion inwardly extends from said detent ring, other said interlock portion outwardly extends from said collar.

40. The dosing syringe of claim 30, wherein said detent ring being disposed about a collar extending from said endcap, said detent ring being releasably lockable to said endcap via a pair of interlock portions, one said interlock portion on said detent ring, other said interlock portion on said endcap.

41. The dosing syringe of claim 30, wherein said plunger being axially movable along said alignment shoulder via sliding engagement between said alignment shoulder and a slot of said endcap.

42. The dosing syringe of claim 30, wherein said barrel includes a barrel wall with a hub at a distal end and a barrel flange at said proximal end, said content being ejectable through said hub, said endcap being secured to said barrel flange at said proximal end.

43. The dosing syringe of claim 30, wherein said detent ring includes a cylindrical portion extending from a ring portion, said tab extends from said ring portion.