WO2023175117A1 - Antibodies against lypd3 - Google Patents

Antibodies against lypd3 Download PDF

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Publication number
WO2023175117A1
WO2023175117A1 PCT/EP2023/056832 EP2023056832W WO2023175117A1 WO 2023175117 A1 WO2023175117 A1 WO 2023175117A1 EP 2023056832 W EP2023056832 W EP 2023056832W WO 2023175117 A1 WO2023175117 A1 WO 2023175117A1
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WO
WIPO (PCT)
Prior art keywords
amino acid
acid sequence
seq
cdr
variable region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2023/056832
Other languages
English (en)
French (fr)
Inventor
Johanna Gellert
Antje Danielczyk
Patrik KEHLER
Anika JÄKEL
Sven Bahrke
Timo LISCHKE
Christoph GOLETZ
Anke FLECHNER
Lars STÖCKL
Stephanie GURKA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycotope GmbH
Original Assignee
Glycotope GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycotope GmbH filed Critical Glycotope GmbH
Priority to CA3253998A priority Critical patent/CA3253998A1/en
Priority to AU2023234686A priority patent/AU2023234686A1/en
Priority to KR1020247032813A priority patent/KR20250021299A/ko
Priority to EP23712015.9A priority patent/EP4493595A1/en
Priority to US18/844,148 priority patent/US20250074999A1/en
Priority to CN202380025716.4A priority patent/CN119421898A/zh
Priority to IL315431A priority patent/IL315431A/en
Priority to JP2024553325A priority patent/JP2025508042A/ja
Publication of WO2023175117A1 publication Critical patent/WO2023175117A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag

Definitions

  • a heavy chain variable region comprising the complementarity-determining regions (CDRs) CDR-H1 having the amino acid sequence of SEQ ID NO: 17, CDR-H2 having the amino acid sequence of SEQ ID NO: 18 and CDR-H3 having the amino acid sequence of SEQ ID NO: 19, and a light chain variable region comprising the complementarity-determining regions (CDRs) CDR-L1 having the amino acid sequence of SEQ ID NO: 20, CDR-L2 having the amino acid sequence of SEQ ID NO: 21 and CDR-L3 having the amino acid sequence of SEQ ID NO: 22; or
  • a heavy chain variable region comprising the complementarity-determining regions (CDRs) CDR-H1 having the amino acid sequence of SEQ ID NO: 25, CDR-H2 having the amino acid sequence of SEQ ID NO: 26 and CDR-H3 having the amino acid sequence of SEQ ID NO: 27, and a light chain variable region comprising the complementarity-determining regions (CDRs) CDR-L1 having the amino acid sequence of SEQ ID NO: 28, CDR-L2 having the amino acid sequence of SEQ ID NO: 29 and CDR-L3 having the amino acid sequence of SEQ ID NO: 30; or
  • a heavy chain variable region comprising the complementarity-determining regions (CDRs) CDR-H1 having the amino acid sequence of SEQ ID NO: 97, CDR-H2 having the amino acid sequence of SEQ ID NO: 98 and CDR-H3 having the amino acid sequence of SEQ ID NO: 99, and a light chain variable region comprising the complementarity-determining regions (CDRs) CDR-L1 having the amino acid sequence of SEQ ID NO: 100, CDR-L2 having the amino acid sequence of SEQ ID NO: 101 and CDR-L3 having the amino acid sequence of SEQ ID NO: 102; or
  • a heavy chain variable region comprising the complementarity-determining regions (CDRs) CDR-H1 having the amino acid sequence of SEQ ID NO: 121 , CDR-H2 having the amino acid sequence of SEQ ID NO: 122 and CDR-H3 having the amino acid sequence of SEQ ID NO: 123, and a light chain variable region comprising the complementarity-determining regions (CDRs) CDR-L1 having the amino acid sequence of SEQ ID NO: 124, CDR-L2 having the amino acid sequence of SEQ ID NO: 125 and CDR-L3 having the amino acid sequence of SEQ ID NO: 126; or
  • the "Fab part” of an antibody in particular refers to a part of the antibody comprising the heavy and light chain variable regions (VH and VL) and the first domains of the heavy and light chain constant regions (CH1 and CL). In cases where the antibody does not comprise all of these regions, then the term “Fab part” only refers to those of the regions VH, VL, CH1 and CL which are present in the antibody.
  • "Fab part” refers to that part of an antibody corresponding to the fragment obtained by digesting a natural antibody with papain which contains the antigen binding activity of the antibody.
  • the Fab part of an antibody encompasses the antigen binding site or antigen binding ability thereof.
  • the Fab part comprises at least the VH region of the antibody.
  • the "Fc part” of an antibody in particular refers to a part of the antibody comprising the heavy chain constant regions 2, 3 and - where applicable - 4 (CH2, CH3 and CH4).
  • the Fc part comprises two of each of these regions.
  • the term "Fc part” only refers to those of the regions CH2, CH3 and CH4 which are present in the antibody.
  • the Fc part comprises at least the CH2 region of the antibody.
  • "Fc part” refers to that part of an antibody corresponding to the fragment obtained by digesting a natural antibody with papain which does not contain the antigen binding activity of the antibody.
  • the Fc part of an antibody is capable of binding to the Fc receptor and thus, e.g. comprises an Fc receptor binding site or an Fc receptor binding ability.
  • Gaipi-3GalNAca1- also called “TF”, “TF antigen”, “T antigen” or “Thomsen Friedenreich antigen” refers to a disaccharide structure consisting of a galactosyl residue attached via a (31-3 bond to an N-acetyl galactosaminyl residue attached via an a1- glycosidic bond to a supporting structure, especially to a serine or threonine residue of a protein or peptide.
  • vector is used here in its most general meaning and comprises any intermediary vehicle for a nucleic acid which enables said nucleic acid, for example, to be introduced into prokaryotic and/or eukaryotic cells and, where appropriate, to be integrated into a genome.
  • Vectors of this kind are preferably replicated and/or expressed in the cells.
  • Vectors comprise plasmids, phagemids, bacteriophages or viral genomes.
  • plasmid as used herein generally relates to a construct of extrachromosomal genetic material, usually a circular DNA duplex, which can replicate independently of chromosomal DNA.
  • metastasis is meant the spread of cancer cells from its original site to another part of the body.
  • the formation of metastasis is a very complex process and normally involves detachment of cancer cells from a primary tumor, entering the body circulation and settling down to grow within normal tissues elsewhere in the body.
  • the new tumor is called a secondary or metastatic tumor, and its cells normally resemble those in the original tumor.
  • the secondary tumor is made up of abnormal breast cells, not of abnormal lung cells.
  • the tumor in the lung is then called metastatic breast cancer, not lung cancer.
  • the antibody is capable of binding to human LYPD3 glycosylated with Gaipi-3GalNAca1-.
  • the antibody binds to LYPD3 if it is glycosylated with Gaipi-3GalNAca1-.
  • LYPD3 may also carry other glycan structures as long as Gaipi-3GalNAca1- is also present.
  • these antibodies specifically bind to human LYPD3 glycosylated with Gaipi-3GalNAca1-.
  • a heavy chain variable region comprising the complementarity-determining regions (CDRs) CDR-H1 having the amino acid sequence of SEQ ID NO: 9, CDR- H2 having the amino acid sequence of SEQ ID NO: 10 and CDR-H3 having the amino acid sequence of SEQ I D NO: 11 , and a light chain variable region comprising the complementarity-determining regions (CDRs) CDR-L1 having the amino acid sequence of SEQ ID NO: 12, CDR-L2 having the amino acid sequence of SEQ I D NO: 13 and CDR-L3 having the amino acid sequence of SEQ ID NO: 14; or
  • a heavy chain variable region comprising the complementarity-determining regions (CDRs) CDR-H1 having the amino acid sequence of SEQ ID NO: 65, CDR-H2 having the amino acid sequence of SEQ ID NO: 66 and CDR-H3 having the amino acid sequence of SEQ ID NO: 67, and a light chain variable region comprising the complementarity-determining regions (CDRs) CDR-L1 having the amino acid sequence of SEQ ID NO: 68, CDR-L2 having the amino acid sequence of SEQ I D NO: 69 and CDR-L3 having the amino acid sequence of SEQ ID NO: 70; or
  • a heavy chain variable region having an amino acid sequence which is at least 60% identical to the amino acid sequence of SEQ ID NO: 47 over its entire length and comprising CDR-H1 having the amino acid sequence of SEQ ID NO: 41 , CDR- H2 having the amino acid sequence of SEQ ID NO: 42 and CDR-H3 having the amino acid sequence of SEQ ID NO: 43, and a light chain variable region having an amino acid sequence which is at least 60% identical to the amino acid sequence of SEQ ID NO: 48 over its entire length and comprising CDR-L1 having the amino acid sequence of SEQ ID NO: 44, CDR-L2 having the amino acid sequence of SEQ ID NO: 45 and CDR-L3 having the amino acid sequence of SEQ ID NO: 46;
  • the antibody according to the invention comprises a heavy chain variable region and a light chain variable region selected from the group consisting of
  • LYPD3 ovarian adenocarcinoma cell line, LYPD3+
  • ZR-75-1 breast carcinoma cell line, LYPD3+
  • MDA-MB-231 breast adenocarcinoma cell line, LYPD3-
  • MDA-MB-231 and ZR-75-1 were treated with sialidase to remove sialic acid from the cell surfaces.
  • Tumor cell lines were stained with aLYPD3 clones and binding was detected using fluorophore-coupled anti-human-IgG secondary reagent.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PCT/EP2023/056832 2022-03-16 2023-03-16 Antibodies against lypd3 Ceased WO2023175117A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA3253998A CA3253998A1 (en) 2022-03-16 2023-03-16 ANTIBODIES DIRECTED AGAINST LYPD3
AU2023234686A AU2023234686A1 (en) 2022-03-16 2023-03-16 Antibodies against lypd3
KR1020247032813A KR20250021299A (ko) 2022-03-16 2023-03-16 Lypd3에 대한 항체
EP23712015.9A EP4493595A1 (en) 2022-03-16 2023-03-16 Antibodies against lypd3
US18/844,148 US20250074999A1 (en) 2022-03-16 2023-03-16 Antibodies against lypd3
CN202380025716.4A CN119421898A (zh) 2022-03-16 2023-03-16 抗lypd3抗体
IL315431A IL315431A (en) 2022-03-16 2023-03-16 Antibodies against lypd3
JP2024553325A JP2025508042A (ja) 2022-03-16 2023-03-16 Ｌｙｐｄ３に対する抗体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22162550.2 2022-03-16
EP22162550 2022-03-16

Publications (1)

Publication Number Publication Date
WO2023175117A1 true WO2023175117A1 (en) 2023-09-21

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Application Number Title Priority Date Filing Date
PCT/EP2023/056832 Ceased WO2023175117A1 (en) 2022-03-16 2023-03-16 Antibodies against lypd3

Country Status (9)

Country Link
US (1) US20250074999A1 (https=)
EP (1) EP4493595A1 (https=)
JP (1) JP2025508042A (https=)
KR (1) KR20250021299A (https=)
CN (1) CN119421898A (https=)
AU (1) AU2023234686A1 (https=)
CA (1) CA3253998A1 (https=)
IL (1) IL315431A (https=)
WO (1) WO2023175117A1 (https=)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008028686A2 (en) 2006-09-10 2008-03-13 Glycotope Gmbh Use of human cells of myeloid leukaemia origin for expression of antibodies
WO2011070088A1 (en) 2009-12-09 2011-06-16 Bayer Schering Pharma Aktiengesellschaft Anti-c4.4a antibodies and uses thereof
WO2016040321A1 (en) * 2014-09-09 2016-03-17 Board Of Regents, The University Of Texas System Blocking monoclonal antibodies to agr2 and its receptor c4.4a
LU92659B1 (en) 2015-02-23 2016-08-24 Glycotope Gmbh Glycooptimized antibody drug conjugates
WO2016166169A1 (en) * 2015-04-17 2016-10-20 Spring Bioscience Corporation Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a
WO2017156280A1 (en) * 2016-03-09 2017-09-14 Viba Therapeutics, Inc. Methods of treating cancer using monoclonal antibodies to agr2 and c4.4a

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008028686A2 (en) 2006-09-10 2008-03-13 Glycotope Gmbh Use of human cells of myeloid leukaemia origin for expression of antibodies
WO2011070088A1 (en) 2009-12-09 2011-06-16 Bayer Schering Pharma Aktiengesellschaft Anti-c4.4a antibodies and uses thereof
WO2016040321A1 (en) * 2014-09-09 2016-03-17 Board Of Regents, The University Of Texas System Blocking monoclonal antibodies to agr2 and its receptor c4.4a
LU92659B1 (en) 2015-02-23 2016-08-24 Glycotope Gmbh Glycooptimized antibody drug conjugates
WO2016166169A1 (en) * 2015-04-17 2016-10-20 Spring Bioscience Corporation Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a
WO2017156280A1 (en) * 2016-03-09 2017-09-14 Viba Therapeutics, Inc. Methods of treating cancer using monoclonal antibodies to agr2 and c4.4a

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* Cited by examiner, † Cited by third party
Title
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JIN YU ET AL: "Induction of Antibodies Directed Against Branched Core O-Mannosyl Glycopeptides-Selectivity Complimentary to the ConA Lectin", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 23, no. 14, 16 February 2017 (2017-02-16), pages 3466 - 3473, XP071842541, ISSN: 0947-6539, DOI: 10.1002/CHEM.201605627 *
LILIANA R. LOUREIRO ET AL: "Preclinical Antitumor Efficacy of BAY 1129980: a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer", SCIENTIFIC REPORTS, vol. 8, no. 1, 15 August 2018 (2018-08-15), XP055567232, DOI: 10.1038/s41598-018-30421-w *
LINE V HANSEN ET AL: "Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor", BIOCHEMICAL JOURNAL, PUBLISHED BY PORTLAND PRESS ON BEHALF OF THE BIOCHEMICAL SOCIETY, GB, vol. 380, no. Part 3, 15 June 2004 (2004-06-15), pages 845 - 857, XP002626955, ISSN: 0264-6021, [retrieved on 20040310], DOI: 10.1042/BJ20031478 *
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