WO2023174379A1 - Method and device for promoting growth of hair - Google Patents

Method and device for promoting growth of hair Download PDF

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Publication number
WO2023174379A1
WO2023174379A1 PCT/CN2023/081967 CN2023081967W WO2023174379A1 WO 2023174379 A1 WO2023174379 A1 WO 2023174379A1 CN 2023081967 W CN2023081967 W CN 2023081967W WO 2023174379 A1 WO2023174379 A1 WO 2023174379A1
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WO
WIPO (PCT)
Prior art keywords
temperature
closed environment
gas
helmet
hair
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PCT/CN2023/081967
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French (fr)
Chinese (zh)
Inventor
陈雄伟
张建超
张瑞红
肖莉
武天中
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爱美客技术发展股份有限公司
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Publication of WO2023174379A1 publication Critical patent/WO2023174379A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0001Body part
    • A61F2007/0002Head or parts thereof
    • A61F2007/0008Scalp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0059Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit
    • A61F2007/006Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit of gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0059Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit
    • A61F2007/0063Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit for cooling
    • A61F2007/0064Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit for cooling of gas

Definitions

  • the present invention relates to the field of beauty, and in particular to a method and device for promoting hair growth.
  • hair loss has become a common problem that plagues people's lives.
  • the causes of hair loss generally include endocrine disorders, mental factors, genetic factors, immune dysfunction and improper diet.
  • Current treatments include medication, laser treatment, hair transplant surgery, etc.
  • Traditional treatment methods such as drug treatment and oral anti-androgen drugs will have problems such as low efficacy and many adverse reactions.
  • Laser treatment will cause a local feeling of heat, tolerable pain or itching during treatment, and a short period of time after treatment.
  • Patent document CN111759576A discloses a refrigeration helmet and hair growth method, which prevents the head temperature from rising too high and maintains the head temperature and humidity within a suitable range for the season, but does not perform a periodic regulation of the temperature to activate hair follicle stem cells. Effect.
  • Patent document CN112932780A discloses a low-temperature hair growth care cap that stimulates hair follicle stem cells with cold to promote hair growth. However, it uses a cold storage bag that cannot accurately regulate the temperature, let alone programmatic control of the temperature.
  • Patent document CN111956389A discloses an adjustable cooling device for preventing drug-induced hair loss. Cooling gas is sent into the inner cavity through a refrigerator. By changing the temperature and speed of the cooling gas, the temperature is controlled and the cap is realized. At the same time, the drug is atomized through an atomizer and sprayed evenly onto the patient's head.
  • this technology can only maintain a constant temperature mode and has limited stimulation of hair follicle stem cells.
  • the invention controls the periodic cooling and heating of the environment around the scalp to stimulate hair follicle stem cells, so that the hair is in a temperature environment suitable for growth and promotes hair growth.
  • non-oxygen gas into the scalp in a closed environment, on the one hand, it can make the scalp surface temperature uniform, on the other hand, it can reduce the oxygen content of the scalp closed environment during cooling, through the synergistic effect of periodic temperature changes and hypoxia. , promotes the growth of hair follicles and is also beneficial to hair growth.
  • the present invention provides a method for promoting hair growth by placing the scalp in a closed environment. Introduce gas to make the oxygen content in the closed environment less than 5%, lower the temperature of the closed environment to -5 ⁇ 20°C, keep it for 1 ⁇ 30min, raise the temperature of the closed environment to 15 ⁇ 30°C, keep it for 1 ⁇ 30min.
  • the oxygen content is less than 3%, preferably, the oxygen content is less than 1.5%, and more preferably, the oxygen content is less than 1%.
  • the scalp When the scalp is in a lower oxygen concentration environment, it is beneficial to stimulate hair follicles and promote hair growth.
  • the process of lowering the temperature of the closed environment and raising the temperature of the closed environment can be repeated 2 to 8 times, and the number of repetitions can be 2, 3, 4, 5, 6, 7 or 8 times.
  • the process of lowering the temperature of the closed environment and raising the temperature of the closed environment can be repeated 2 to 3 times.
  • the temperature reduction rate of the method is 0.1-20°C/min, more preferably 1-10°C/min.
  • the steps of introducing gas into the closed environment and lowering the temperature of the closed environment can be performed simultaneously or successively.
  • the gas is introduced and the temperature of the closed environment is reduced at the same time, or the temperature of the closed environment is reduced first and then the gas is introduced, or the gas is introduced first and then the temperature of the closed environment is reduced.
  • the gas is introduced and the temperature of the closed environment is reduced at the same time.
  • the inflow of gas drives the flow of gas in the closed environment where the scalp is located, and achieves a uniform distribution of the temperature of the environment where the scalp is located.
  • the gas is a non-oxygen gas, including but not limited to one or more of carbon dioxide, hydrogen, nitrogen, helium or argon.
  • the gas is carbon dioxide or nitrogen.
  • the gas is provided by physical means or chemical means.
  • the gas can be generated by the contact between the effervescent tablet and water.
  • the effervescent tablet is pressed by mixing sodium bicarbonate and citric acid, and under the condition of contact with water Produce carbon dioxide.
  • the method further includes removing condensed water in the closed environment to keep the closed environment dry.
  • the temperature of the closed environment is reduced to 0-16°C, for example: the temperature of the closed environment is reduced to 0°C, 1°C, 2°C, 3°C, 4°C, 5°C, 6°C, 7°C, 8°C °C, 9°C, 10°C, 11°C, 12°C, 13°C, 14°C, 15°C, 16°C;
  • the lowered closed environment temperature is 6 to 14°C;
  • the reduced closed environment temperature may be 6.9-9.3°C, 6.9-13.2°C, 7.2-9°C, 7.2-13.2°C, 7.6-13.2°C, 9.3-11.1°C and 9.3-13.2°C;
  • the holding time of the low temperature environment is 2 to 20 minutes; preferably, the holding time is 5 to 15 minutes;
  • the holding time can be 5min, 6min, 7min, 8min, 9min, 10min, 11min, 12min, 13min, 14min and 15min;
  • the elevated ambient temperature is 15-30°C; preferably, the holding time is 2-20 minutes.
  • the ambient temperature can be increased to 15°C, 16°C, 17°C, 18°C, 19°C, 20°C, 21°C, 22°C, 23°C, 24°C, 25°C, 26°C, 27°C, 28°C, 29°C and 30°C;
  • the holding time can be 2min, 3min, 4min, 5min, 6min, 7min, 8min, 9min, 10min, 11min, 12min, 13min, 14min, 15min, 16min, 17min, 18min, 19min and 20min;
  • the temperature of the closed environment is raised from natural heating, gas heating or heating.
  • the gas is a non-oxygen gas, including but not limited to one or more of carbon dioxide, hydrogen, nitrogen, helium or argon.
  • the gas is carbon dioxide or nitrogen.
  • the present invention provides a device for promoting hair growth, which is characterized in that the device includes: a helmet, a temperature control system and a gas generating component.
  • the helmet is provided with a cavity suitable for being worn on the head, and a sealing ring is provided at the bottom of the cavity to keep the scalp in a closed environment;
  • the helmet is provided with a one-way valve, and the one-way valve is used to eliminate gas in the helmet;
  • the helmet is provided with a temperature control system for adjusting the temperature inside the helmet;
  • the temperature control system includes a refrigeration component for reducing the temperature inside the helmet;
  • the temperature control system includes a heating component for raising the temperature inside the helmet;
  • the gas generating component is used to introduce gas into a closed environment; wherein the gas generating component is arranged on the helmet and leads to the inside of the helmet through a gas pipeline, or the gas generating component and the helmet are connected through a gas The pipelines are connected, and the gas pipeline leads to the inside of the helmet.
  • the device for promoting hair growth also includes a temperature balancing component to make the temperature in the cavity uniform.
  • the temperature equalization component is a thermally conductive mesh or thermally conductive sheet arranged inside the helmet, and the thermally conductive mesh or thermally conductive sheet is connected to the temperature control system; more preferably, the material of the thermally conductive mesh or thermally conductive sheet is selected from the group consisting of: Metal; Particularly preferably, the metal is selected from aluminum, magnesium, iron, copper, gold, silver, nickel or alloys.
  • the temperature control system includes a refrigeration component, and the refrigeration component is a semiconductor refrigerator; preferably, the number of the semiconductor refrigerators is 1 to 10, and more preferably 1 to 5.
  • the semiconductor refrigerator is installed inside the helmet for cooling, and a fan is used externally to increase the heat dissipation rate.
  • the cavity ambient temperature drops to about 10°C in 15 minutes.
  • the refrigeration components are distributed on both sides and the top of the helmet, so that The temperature in the cavity can be evenly distributed.
  • the gas generating assembly includes a gas generating chamber, and the gas generating chamber is used for generating gas.
  • the gas generating chamber is used for generating gas.
  • an effervescent tablet and water are placed in the gas generating chamber to generate carbon dioxide gas.
  • solid carbon dioxide dry ice is placed in the gas generating chamber and the lid is closed. The dry ice generates dioxide by absorbing heat from the environment and sublimes. carbon gas. At this time, gas can be generated in situ, simplifying the structure of the hair growth device, reducing weight, and making it easy to carry.
  • the device for promoting hair growth further includes a dehumidification component, which is connected to the helmet and used to eliminate condensation water generated when the refrigeration component is working; preferably, the dehumidification component includes a desiccant or an absorbent sponge.
  • the device for promoting hair growth also includes a temperature sensor, which is arranged on the inside of the helmet to monitor the temperature of the cavity. Furthermore, the inner or outer layer of the device helmet has a thermal insulation layer, and the thermal insulation layer can effectively reduce temperature loss.
  • the sealing ring provided at the bottom of the cavity is made of elastic material.
  • the device includes a temperature sensor, which is arranged on the inside of the helmet to monitor the temperature of the internal cavity and provide feedback signals for cavity temperature control and adjustment.
  • the device may include an oxygen content monitoring display for displaying the monitored oxygen concentration inside the cavity.
  • the device can be charged or powered by a mobile power source.
  • the use process of the device for promoting hair growth according to the present invention includes: setting the temperature T1, cooling down, maintaining the low temperature, increasing the setting temperature T2, raising the temperature, and maintaining the setting temperature. To enhance the effect, the above process can be repeated for each treatment.
  • the use process of the device for promoting hair growth includes: the user puts on a headgear, then puts on a helmet, starts the hair growth device, turns on the low temperature mode, causes the cavity to reach the set temperature T1, and maintains the time t1 ; Turn off the low temperature mode, turn on the heating mode, make the cavity reach the set temperature T2, and maintain the time t2; cycle like this 2 to 4 times.
  • the T1 is selected from 6 to 14°C
  • the T2 is selected from 15 to 30°C
  • the holding times t1 and t2 are independently selected from 2 to 20 min;
  • the heating method of the device includes one or a combination of: natural heating, introducing gas from the outside to raise the temperature, heating by a heating component.
  • the maintenance of the temperature after heating can be controlled by individually adjusting the refrigeration power of the refrigeration component, or the refrigeration component and the heating component can be controlled collaboratively, with the priority being controlled by the refrigeration component individually adjusting the refrigeration power.
  • the switches of the temperature control component and the gas generating component are provided on the helmet of the device;
  • the switches of the temperature control component and the gas generating component can be controlled by the control terminal in a wired or wireless manner.
  • the first method of constructing the temperature balancing component is a metal thermal conductive sheet connected to the semiconductor refrigerator to achieve uniform temperature distribution through solid heat conduction; the second method uses gas inflow and outflow to drive the gas in the internal cavity of the device Flow, the two methods can be used alone or together.
  • the invention also provides an application of the device for promoting hair growth in the field of beauty.
  • the beauty treatment includes: preventing and/or treating hair loss and sparse body hair;
  • the hair loss includes: androgenic alopecia, alopecia areata, scarring alopecia, infectious alopecia, congenital alopecia, One or more combinations of physiological alopecia and chemotherapy-induced alopecia.
  • the hair loss includes androgenic alopecia and/or hair loss caused by chemotherapy.
  • Figure 1 is a sectional structural view of the hair growth device
  • Figure 2 is a top structural view of the hair growth device
  • 1-helmet 2-insulation layer, 3-temperature sensor, 4-exhaust one-way valve, 5-gas generating component, 6-dehumidification device, 7-temperature control system, 8-heat conductive mesh, 9-sealing ring .
  • Figure 3 is an effect diagram before and after using the device in Embodiment 3;
  • Figure 4 is a diagram of the hair growth effect of Comparative Example 2.
  • horizontal does not imply a requirement that the component be absolutely horizontal or overhanging, but may be slightly tilted.
  • “horizontal” only means that its direction is more horizontal than “vertical”. It does not mean that the structure must be completely horizontal, but can be slightly tilted.
  • the terms “set”, “installation”, “connected” and “connected” should be understood in a broad sense.
  • it can be a fixed connection, It can also be a detachable connection or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be an internal connection between two components.
  • the specific meanings of the above terms in the present invention can be understood on a case-by-case basis.
  • the device of the present invention includes a helmet 1 suitable for human body wear.
  • the outer surface of the helmet has an insulation layer 2.
  • the helmet 1 and an elastic sealing ring 9 jointly construct a relatively closed cavity inside; a temperature sensor 3. Collect the internal cavity temperature to provide feedback signals for cavity temperature control and adjustment; effervescent tablets and water are placed in the gas generating component 5 to generate carbon dioxide gas; the one-way valve 4 can discharge excess gas to maintain the normal air pressure of the internal cavity ;
  • the temperature control system 7 is a semiconductor refrigeration module with a refrigeration function; the refrigeration temperature can be set, the refrigeration module is connected to a thin copper mesh, and the thin copper mesh covers the inner surface of the cavity.
  • the dehumidification device 6 is a sponge that absorbs condensed water droplets generated by the semiconductor refrigeration module when the device is running.
  • the device of Example 1 When using the device of Example 1, place an effervescent tablet and water (2 ml) in the gas generating component 5 of the device of Example 1, where the effervescent tablet is commercially available (the main ingredients include citric acid, sodium bicarbonate, lactose , sorbitol, sweet orange powder, vitamin C). Cover the lid, and the effervescent tablets and water will generate carbon dioxide gas. The generated carbon dioxide gas flow will push the gas flow in the cavity inside the device, and the excess gas will be discharged from the one-way valve 4. After the device ran for 5 minutes, the oxygen concentration in the internal cavity was detected and the measured oxygen concentration was 0.9%.
  • the main ingredients include citric acid, sodium bicarbonate, lactose , sorbitol, sweet orange powder, vitamin C.
  • the operation is the same as above.
  • the difference is that while the aforementioned temperature control system is started, the gas generating component 5 is closed, and the refrigeration temperature is set to 10°C. After the temperature stabilizes, it is maintained for 5 minutes, and the temperature in the cavity is The temperature is monitored at five points: top center, left center, right center, rear center, and front center. The highest temperature is 13.2°C and the lowest is 7.6°C.
  • solid carbon dioxide dry ice is placed in the gas generating component 5 of the device of Embodiment 1, and the lid is closed.
  • the dry ice generates carbon dioxide gas by absorbing thermal sublimation from the environment, and the generated carbon dioxide gas flow drives the device.
  • the gas in the internal cavity flows, and the excess gas is discharged from the one-way valve 4.
  • the oxygen concentration in the internal cavity was detected and the measured oxygen concentration was 0.1%, indicating that carbon dioxide gas effectively promoted the flow of internal air and exhausted most of the original air.
  • the operation is the same as described above.
  • the difference is that while the temperature control system 7 device is started, the gas generating component 5 is turned off, and the refrigeration temperature is set to 8°C. After the temperature is stabilized, it is maintained for 5 minutes and the cavity is The temperature is monitored at five points at the center of the inner top, left center, right center, rear center, and front center. The highest temperature is 9.3°C and the lowest is 6.9°C.
  • the method of the present invention regulates the scalp surface temperature by periodically cooling and heating, and stimulates the scalp with hot and cold. It also reduces the oxygen concentration of the surrounding environment, reduces the blood supply to hair follicles, provides continuous low oxygen, affects the metabolism of hair follicle stem cells, and the metabolites are beneficial to increase the activity and lifespan of hair follicle stem cells.
  • the hair follicle stem cells of the scalp are further stimulated, thereby promoting hair growth and having a hair-fixing effect.
  • Comparative Example 1 only simple cooling-heating control is used, which has limited stimulation of hair follicles on the scalp, and the hair growth effect is not ideal; in Comparative Example 2, although systematic cooling-heating control is used, it can stimulate the scalp, but due to the oxygen in the surrounding environment At a higher concentration, hair follicle cells can obtain oxygen from the air. At this time, the metabolic mechanism of hair follicle stem cells is different and the hair follicle stem cells cannot be effectively stimulated. Therefore, the synergistic effect of temperature change and hypoxia cannot be exerted, and the hair growth effect is average. Therefore, compared with the simple cooling-heating control in Comparative Example 1 and the high oxygen-containing environment in Comparative Example 2, the present invention has a more effective hair growth effect.

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Abstract

A method and device for promoting the growth of hair. The method for promoting the growth of hair comprises placing a scalp in a closed environment, introducing gas into the closed environment to lower the oxygen content in the closed environment to below 5%, reducing the temperature of the closed environment to -5-20°C, maintaining the temperature for 1-30 min, increasing the temperature of the closed environment to 15-30°C, and maintaining the temperature for 1-30 min. The device for promoting the growth of hair comprises a helmet (1), a temperature control system (7) and a gas generation assembly (5). According to the device, the temperature can be accurately controlled; hair follicle stem cells of the scalp are effectively activated by means of the synergistic effect of a low-oxygen environment and periodic cooling-heating; the growth of hair is promoted; condensate water generated in the treatment process can be removed; and the wearing comfort is improved.

Description

一种促进毛发生长的方法和装置A method and device for promoting hair growth 技术领域Technical field
本发明涉及美容领域,具体涉及一种促进毛发生长的方法和装置。The present invention relates to the field of beauty, and in particular to a method and device for promoting hair growth.
背景技术Background technique
随着现代生活节奏的加快,脱发已经变成困扰人们生活的普遍性问题。引起脱发的原因一般有内分泌紊乱、精神因素、遗传因素、免疫功能障碍及饮食不当等。当前的治疗方法包括药物治疗、激光治疗,植发手术等方式。采用药物治疗,抗雄激素药物口服等传统的治疗方法会出现疗效低和不良反应多等问题,采用激光治疗,治疗时局部会有热的感觉、可忍受的疼痛或瘙痒、治疗后短时间内的局部红斑,激光治疗参数设置在过高的能量水平或使用过高频率可能实际上会恶化脱发,诱导毛囊纤维化的产生,并且高能量的激光也会造成局部长时间红斑、水肿,溃疡甚至疤痕的产生。采用植发手术治疗,不仅成本高昂,而且会产生不可避免的并发症,如疼痛、肿胀、渗血、感染等,并且毛囊的成活率不一定高。With the accelerated pace of modern life, hair loss has become a common problem that plagues people's lives. The causes of hair loss generally include endocrine disorders, mental factors, genetic factors, immune dysfunction and improper diet. Current treatments include medication, laser treatment, hair transplant surgery, etc. Traditional treatment methods such as drug treatment and oral anti-androgen drugs will have problems such as low efficacy and many adverse reactions. Laser treatment will cause a local feeling of heat, tolerable pain or itching during treatment, and a short period of time after treatment. For local erythema, setting laser treatment parameters at too high an energy level or using too high a frequency may actually worsen hair loss and induce hair follicle fibrosis, and high-energy lasers can also cause local long-term erythema, edema, ulcers and even The production of scars. Hair transplantation surgery is not only expensive, but will also produce inevitable complications, such as pain, swelling, bleeding, infection, etc., and the survival rate of hair follicles is not necessarily high.
专利文献CN111759576A公开了一种制冷头盔及生发方法,通过防止头部温度升温过高,维持头部温度和湿度在一个当季合适的范围,但没有对温度进行一个周期性调控激活毛囊干细胞来实现效果。Patent document CN111759576A discloses a refrigeration helmet and hair growth method, which prevents the head temperature from rising too high and maintains the head temperature and humidity within a suitable range for the season, but does not perform a periodic regulation of the temperature to activate hair follicle stem cells. Effect.
专利文献CN112932780A公开的一种低温生发护理帽,通过冷刺激毛囊干细胞来促进头发生长,但其采用蓄冷袋的方式不能对温度进行精准调控,更没法对温度进行程序性控制。Patent document CN112932780A discloses a low-temperature hair growth care cap that stimulates hair follicle stem cells with cold to promote hair growth. However, it uses a cold storage bag that cannot accurately regulate the temperature, let alone programmatic control of the temperature.
专利文献CN111956389A公开的一种可调节防药物性脱发的降温装置,通过冷冻机,将冷却气体送入到内腔中,通过改变送入冷却气体的温度和速度,实现对温度的控制,实现帽体的恒温效果,同时,通过雾化器,将药物进行雾化处理,均匀喷涂到患者的头部,但是该技术仅能保持恒温模式,对毛囊干细胞的刺激有限。Patent document CN111956389A discloses an adjustable cooling device for preventing drug-induced hair loss. Cooling gas is sent into the inner cavity through a refrigerator. By changing the temperature and speed of the cooling gas, the temperature is controlled and the cap is realized. At the same time, the drug is atomized through an atomizer and sprayed evenly onto the patient's head. However, this technology can only maintain a constant temperature mode and has limited stimulation of hair follicle stem cells.
发明内容Contents of the invention
本发明通过控制头皮周围环境的周期性降温和升温,刺激毛囊干细胞,使头发处于适宜生长的温度环境中,促进头发的生长。同时,通过向处于封闭环境的头皮输入非氧气体,一方面能够使头皮表面温度均一,另一方面,减少降温时头皮封闭环境的含氧量,通过周期性的温度变化和低氧的协同作用,促进毛囊的生长,也有利于毛发生长。The invention controls the periodic cooling and heating of the environment around the scalp to stimulate hair follicle stem cells, so that the hair is in a temperature environment suitable for growth and promotes hair growth. At the same time, by inputting non-oxygen gas into the scalp in a closed environment, on the one hand, it can make the scalp surface temperature uniform, on the other hand, it can reduce the oxygen content of the scalp closed environment during cooling, through the synergistic effect of periodic temperature changes and hypoxia. , promotes the growth of hair follicles and is also beneficial to hair growth.
本发明的目的通过以下技术方案予以实现:The purpose of the present invention is achieved through the following technical solutions:
本发明提供一种促进毛发生长的方法,该方法通过使头皮处于封闭环境中,向封闭环境中 通入气体,使封闭环境中的含氧量低于5%,降低封闭环境温度至-5~20℃,保持1~30min,升高封闭环境温度至15~30℃,保持1~30min。The present invention provides a method for promoting hair growth by placing the scalp in a closed environment. Introduce gas to make the oxygen content in the closed environment less than 5%, lower the temperature of the closed environment to -5~20℃, keep it for 1~30min, raise the temperature of the closed environment to 15~30℃, keep it for 1~30min.
进一步的,所述含氧量低于3%,优选的,所述含氧量低于1.5%,更优选的,所述含氧量低于1%。Further, the oxygen content is less than 3%, preferably, the oxygen content is less than 1.5%, and more preferably, the oxygen content is less than 1%.
当头皮处于较低的氧气浓度环境时,有利于刺激毛囊,促进毛发生长。When the scalp is in a lower oxygen concentration environment, it is beneficial to stimulate hair follicles and promote hair growth.
进一步的,所述的降低封闭环境温度和升高封闭环境温度的过程可以重复2~8次,重复次数可以为2、3、4、5、6、7或8次。Further, the process of lowering the temperature of the closed environment and raising the temperature of the closed environment can be repeated 2 to 8 times, and the number of repetitions can be 2, 3, 4, 5, 6, 7 or 8 times.
优选的,所述的降低封闭环境温度和升高封闭环境温度的过程可以重复2~3次。Preferably, the process of lowering the temperature of the closed environment and raising the temperature of the closed environment can be repeated 2 to 3 times.
进一步的,所述方法的降低温度的速率为0.1~20℃/min,更优选为1~10℃/min。Further, the temperature reduction rate of the method is 0.1-20°C/min, more preferably 1-10°C/min.
进一步的,所述方法中封闭环境中通入气体和降低封闭环境温度步骤可以同时或先后进行。例如,通入气体和降低封闭环境温度同时进行,或者,先降低封闭环境的温度,再通入气体,或者,先通入气体,再降低封闭环境的温度。优选的,所述的方法中通入气体和降低封闭环境温度同时进行,通过气体流入,带动头皮所处的封闭环境的气体流动,实现头皮所处环境的温度的均一分布。Furthermore, in the method, the steps of introducing gas into the closed environment and lowering the temperature of the closed environment can be performed simultaneously or successively. For example, the gas is introduced and the temperature of the closed environment is reduced at the same time, or the temperature of the closed environment is reduced first and then the gas is introduced, or the gas is introduced first and then the temperature of the closed environment is reduced. Preferably, in the method, the gas is introduced and the temperature of the closed environment is reduced at the same time. The inflow of gas drives the flow of gas in the closed environment where the scalp is located, and achieves a uniform distribution of the temperature of the environment where the scalp is located.
进一步的,所述气体为非氧气体,包括不限于二氧化碳、氢气、氮气、氦气或氩气中的一种或多种。优选的,所述的气体为二氧化碳或氮气。Further, the gas is a non-oxygen gas, including but not limited to one or more of carbon dioxide, hydrogen, nitrogen, helium or argon. Preferably, the gas is carbon dioxide or nitrogen.
进一步的,所述气体通过物理方式或化学方式提供,优选的,所述气体可由泡腾片与水接触产生,例如,泡腾片采用碳酸氢钠与柠檬酸混合压制,与水接触的条件下产生二氧化碳。Further, the gas is provided by physical means or chemical means. Preferably, the gas can be generated by the contact between the effervescent tablet and water. For example, the effervescent tablet is pressed by mixing sodium bicarbonate and citric acid, and under the condition of contact with water Produce carbon dioxide.
进一步的,所述方法还包括去除封闭环境中的冷凝水,使封闭环境保持干燥。Further, the method further includes removing condensed water in the closed environment to keep the closed environment dry.
进一步的,所述方法中降低封闭环境温度至0~16℃,例如是:降低封闭环境温度至0℃、1℃、2℃、3℃、4℃、5℃、6℃、7℃、8℃、9℃、10℃、11℃、12℃、13℃、14℃、15℃、16℃;Further, in the method, the temperature of the closed environment is reduced to 0-16°C, for example: the temperature of the closed environment is reduced to 0°C, 1°C, 2°C, 3°C, 4°C, 5°C, 6°C, 7°C, 8°C ℃, 9℃, 10℃, 11℃, 12℃, 13℃, 14℃, 15℃, 16℃;
优选的,所述降低封闭环境温度为6~14℃;Preferably, the lowered closed environment temperature is 6 to 14°C;
例如,所述降低封闭环境温度可以是6.9~9.3℃、6.9~13.2℃、7.2~9℃、7.2~13.2℃、7.6~13.2℃、9.3~11.1℃和9.3~13.2℃;For example, the reduced closed environment temperature may be 6.9-9.3°C, 6.9-13.2°C, 7.2-9°C, 7.2-13.2°C, 7.6-13.2°C, 9.3-11.1°C and 9.3-13.2°C;
进一步的,所述低温环境的保持时间为2~20min;优选的,所述保持时间为5~15min;Further, the holding time of the low temperature environment is 2 to 20 minutes; preferably, the holding time is 5 to 15 minutes;
例如,所述保持时间可以为5min、6min、7min、8min、9min、10min、11min、12min、13min、14min和15min;For example, the holding time can be 5min, 6min, 7min, 8min, 9min, 10min, 11min, 12min, 13min, 14min and 15min;
优选的,所述升高环境温度为15~30℃;优选的,所述保持时间为2~20min。 Preferably, the elevated ambient temperature is 15-30°C; preferably, the holding time is 2-20 minutes.
例如,升高环境温度为可以升高至15℃、16℃、17℃、18℃、19℃、20℃、21℃、22℃、23℃、24℃、25℃、26℃、27℃、28℃、29℃和30℃;For example, the ambient temperature can be increased to 15℃, 16℃, 17℃, 18℃, 19℃, 20℃, 21℃, 22℃, 23℃, 24℃, 25℃, 26℃, 27℃, 28℃, 29℃ and 30℃;
例如,所述保持时间可以为2min、3min、4min、5min、6min、7min、8min、9min、10min、11min、12min、13min、14min、15min、16min、17min、18min、19min和20min;For example, the holding time can be 2min, 3min, 4min, 5min, 6min, 7min, 8min, 9min, 10min, 11min, 12min, 13min, 14min, 15min, 16min, 17min, 18min, 19min and 20min;
进一步的,所述的方法中升高封闭环境温度选自自然升温、通入气体升温或加热升温。Furthermore, in the method, the temperature of the closed environment is raised from natural heating, gas heating or heating.
所述气体为非氧气体,包括不限于二氧化碳、氢气、氮气、氦气或氩气中的一种或多种。优选的,所述的气体为二氧化碳或氮气。The gas is a non-oxygen gas, including but not limited to one or more of carbon dioxide, hydrogen, nitrogen, helium or argon. Preferably, the gas is carbon dioxide or nitrogen.
本发明提供一种促进毛发生长的装置,其特征在于,所述装置包括:头盔、温度控制系统和气体发生组件。The present invention provides a device for promoting hair growth, which is characterized in that the device includes: a helmet, a temperature control system and a gas generating component.
进一步的,所述头盔设置有适于头部佩戴的空腔,所述的空腔底部设置有密封圈,用于使头皮处于封闭环境;Further, the helmet is provided with a cavity suitable for being worn on the head, and a sealing ring is provided at the bottom of the cavity to keep the scalp in a closed environment;
进一步的,所述头盔上设置有单向阀,所述的单向阀用于排除头盔内的气体;Further, the helmet is provided with a one-way valve, and the one-way valve is used to eliminate gas in the helmet;
进一步的,所述头盔上设置有温度控制系统,用于调节头盔内温度;Further, the helmet is provided with a temperature control system for adjusting the temperature inside the helmet;
优选的,所述温度控制系统包括制冷组件,用于降低头盔内温度;Preferably, the temperature control system includes a refrigeration component for reducing the temperature inside the helmet;
更优选的,所述温度控制系统包括加热组件,用于升高头盔内温度;More preferably, the temperature control system includes a heating component for raising the temperature inside the helmet;
进一步的,所述气体发生组件用于向封闭环境中通入气体;其中,所述气体发生组件设置在头盔上,通过气体管路通向头盔内部,或者,所述气体发生组件与头盔通过气体管路相连,所述的气体管路通向头盔内部。Further, the gas generating component is used to introduce gas into a closed environment; wherein the gas generating component is arranged on the helmet and leads to the inside of the helmet through a gas pipeline, or the gas generating component and the helmet are connected through a gas The pipelines are connected, and the gas pipeline leads to the inside of the helmet.
进一步的,所述促进毛发生长的装置还包括温度均衡组件,使空腔内温度均一。Furthermore, the device for promoting hair growth also includes a temperature balancing component to make the temperature in the cavity uniform.
优选的,所述的温度均衡组件为设置在头盔内部的导热网或导热片,所述的导热网或导热片与温度控制系统相连;更优选的,所述导热网或导热片的材料选自金属;特别优选的,所述的金属选自铝、镁、铁、铜、金、银、镍或合金。Preferably, the temperature equalization component is a thermally conductive mesh or thermally conductive sheet arranged inside the helmet, and the thermally conductive mesh or thermally conductive sheet is connected to the temperature control system; more preferably, the material of the thermally conductive mesh or thermally conductive sheet is selected from the group consisting of: Metal; Particularly preferably, the metal is selected from aluminum, magnesium, iron, copper, gold, silver, nickel or alloys.
进一步的,所述温度控制系统包括制冷组件,所述制冷组件为半导体制冷器;优选的,所述半导体制冷器的设置数量为1~10个,更优选为1~5个。半导体制冷器设置在头盔内部制冷,外部使用风扇增加散热速率,在本发明的实施方式中,15min空腔环境温度下降至10℃左右,进一步的,将制冷组件分布在头盔两侧和顶部,使得空腔内温度可以均匀分布。Further, the temperature control system includes a refrigeration component, and the refrigeration component is a semiconductor refrigerator; preferably, the number of the semiconductor refrigerators is 1 to 10, and more preferably 1 to 5. The semiconductor refrigerator is installed inside the helmet for cooling, and a fan is used externally to increase the heat dissipation rate. In the embodiment of the present invention, the cavity ambient temperature drops to about 10°C in 15 minutes. Furthermore, the refrigeration components are distributed on both sides and the top of the helmet, so that The temperature in the cavity can be evenly distributed.
进一步的,气体发生组件包括气体发生腔,所述的气体发生腔用于气体的产生。在一种实施方式中,所述的气体发生腔内放置泡腾片和水,产生二氧化碳气体。在另一种实施方式中,所述的气体发生腔内放置固态二氧化碳干冰,盖好盖子,干冰通过吸收环境中热升华产生二氧 化碳气体。此时,气体可原位产生,简化生发装置的结构,降低重量,携带方便。Further, the gas generating assembly includes a gas generating chamber, and the gas generating chamber is used for generating gas. In one embodiment, an effervescent tablet and water are placed in the gas generating chamber to generate carbon dioxide gas. In another embodiment, solid carbon dioxide dry ice is placed in the gas generating chamber and the lid is closed. The dry ice generates dioxide by absorbing heat from the environment and sublimes. carbon gas. At this time, gas can be generated in situ, simplifying the structure of the hair growth device, reducing weight, and making it easy to carry.
进一步的,所述促进毛发生长的装置还包括除湿组件,所述除湿组件与头盔相连接,用于消除制冷组件工作时产生的冷凝水;优选的,所述除湿组件包括干燥剂或吸水海绵。Further, the device for promoting hair growth further includes a dehumidification component, which is connected to the helmet and used to eliminate condensation water generated when the refrigeration component is working; preferably, the dehumidification component includes a desiccant or an absorbent sponge.
进一步的,所述促进毛发生长的装置还包含温度传感器,所述温度传感器设置在头盔内侧,监测空腔温度。进一步的,所述装置头盔的内层或外层具有保温层,所述保温层能够有效减小温度损耗。Furthermore, the device for promoting hair growth also includes a temperature sensor, which is arranged on the inside of the helmet to monitor the temperature of the cavity. Furthermore, the inner or outer layer of the device helmet has a thermal insulation layer, and the thermal insulation layer can effectively reduce temperature loss.
进一步的,所述的空腔底部设置的密封圈为弹性材料。Furthermore, the sealing ring provided at the bottom of the cavity is made of elastic material.
进一步的,所述装置包含温度传感器,所述温度传感器设置在头盔内侧,监测内部空腔温度并给空腔温度控制调节提供反馈信号。Further, the device includes a temperature sensor, which is arranged on the inside of the helmet to monitor the temperature of the internal cavity and provide feedback signals for cavity temperature control and adjustment.
进一步的,所述装置可包含氧含量监测显示器,用于显示所监测到的空腔内部的氧气浓度。Further, the device may include an oxygen content monitoring display for displaying the monitored oxygen concentration inside the cavity.
进一步的,所述装置可充电或采用移动电源供电。Furthermore, the device can be charged or powered by a mobile power source.
本发明所述促进毛发生长的装置使用过程包括:设置温度T1,降温,保持低温,调高设置温度T2,升温,保持设置温度。为加强效果,每次治疗时可重复以上工作过程。The use process of the device for promoting hair growth according to the present invention includes: setting the temperature T1, cooling down, maintaining the low temperature, increasing the setting temperature T2, raising the temperature, and maintaining the setting temperature. To enhance the effect, the above process can be repeated for each treatment.
在本发明的一些实施例中,所述促进毛发生长的装置使用过程包括:使用者戴头套,再带上头盔,启动生发装置,开启低温模式,使空腔达到设定温度T1,保持时间t1;关闭低温模式,开启升温模式,使空腔达到设定温度T2,保持时间t2;如此循环2~4次。In some embodiments of the present invention, the use process of the device for promoting hair growth includes: the user puts on a headgear, then puts on a helmet, starts the hair growth device, turns on the low temperature mode, causes the cavity to reach the set temperature T1, and maintains the time t1 ; Turn off the low temperature mode, turn on the heating mode, make the cavity reach the set temperature T2, and maintain the time t2; cycle like this 2 to 4 times.
所述T1选自6~14℃,所述T2选自15~30℃,所述保持时间t1、t2独立的选自2~20min;The T1 is selected from 6 to 14°C, the T2 is selected from 15 to 30°C, and the holding times t1 and t2 are independently selected from 2 to 20 min;
进一步的,所述装置升温方式包括:自然升温、由外部导入气体来升高温度、由加热组件加热中的一种或者多种的组合。Furthermore, the heating method of the device includes one or a combination of: natural heating, introducing gas from the outside to raise the temperature, heating by a heating component.
进一步的,升温后温度的维持可单独调节制冷组件的制冷功率来控制,也可以制冷组件与加热组件协同控制,优先选择由制冷组件单独调节制冷功率来控制。Furthermore, the maintenance of the temperature after heating can be controlled by individually adjusting the refrigeration power of the refrigeration component, or the refrigeration component and the heating component can be controlled collaboratively, with the priority being controlled by the refrigeration component individually adjusting the refrigeration power.
在本发明的一些实施例中,所述温度控制组件、气体发生组件的开关设置在装置的头盔上;In some embodiments of the present invention, the switches of the temperature control component and the gas generating component are provided on the helmet of the device;
和/或,所述温度控制组件、气体发生组件的开关可通过有线或无线的方式由控制终端控制。And/or, the switches of the temperature control component and the gas generating component can be controlled by the control terminal in a wired or wireless manner.
在本发明的一些实施例中,温度均衡组件构成方式一为与半导体制冷器相连金属导热片,通过固体导热的方式实现温度均匀分布;方式二通过气体流入和流出,带动装置内部空腔的气体流动,两种方式可单独采用,也可以共同采用。In some embodiments of the present invention, the first method of constructing the temperature balancing component is a metal thermal conductive sheet connected to the semiconductor refrigerator to achieve uniform temperature distribution through solid heat conduction; the second method uses gas inflow and outflow to drive the gas in the internal cavity of the device Flow, the two methods can be used alone or together.
本发明还提供一种所述的促进毛发生长的装置在美容领域中的应用。The invention also provides an application of the device for promoting hair growth in the field of beauty.
优选的,所述美容包括:预防和/或治疗脱发、体毛稀少;Preferably, the beauty treatment includes: preventing and/or treating hair loss and sparse body hair;
更优选的,所述脱发包括:雄激素性脱发、斑秃、瘢痕性脱发、感染性脱发、先天性脱发、 生理性脱发和化疗所导致的脱发中的一种或多种的组合。优选的,所述脱发包括雄激素性脱发和/或化疗所导致的脱发。More preferably, the hair loss includes: androgenic alopecia, alopecia areata, scarring alopecia, infectious alopecia, congenital alopecia, One or more combinations of physiological alopecia and chemotherapy-induced alopecia. Preferably, the hair loss includes androgenic alopecia and/or hair loss caused by chemotherapy.
本发明的有益效果:Beneficial effects of the present invention:
通过周期性的调控头皮温度,先降低头皮表面温度,收缩毛细血管,减少毛囊供血,形成短时间的低氧,再升高温度,温热头皮,通过冷热交替的方式进一步刺激头皮,同时结合降低头皮表面的氧气浓度,为毛囊创造持续的低氧环境,刺激毛囊干细胞的代谢,其代谢产物有利于增加毛囊干细胞的活性和寿命。通过周期性的冷热交替和低氧环境的协同作用,刺激毛囊干细胞的生长,进而达到促进毛发生长以及固发的作用。采用本发明方法和装置,每周进行治疗,持续数月后,可使使用者头发密度大幅度提升,达到促进生发的效果。By periodically regulating the scalp temperature, we first lower the surface temperature of the scalp, shrink capillaries, reduce blood supply to hair follicles, and form short-term hypoxia, then increase the temperature to warm the scalp, further stimulate the scalp through alternating hot and cold, and at the same time combine Reduce the oxygen concentration on the scalp surface, create a continuous low-oxygen environment for hair follicles, stimulate the metabolism of hair follicle stem cells, and its metabolite products are beneficial to increase the activity and lifespan of hair follicle stem cells. Through the synergistic effect of periodic alternations of hot and cold and a low-oxygen environment, the growth of hair follicle stem cells is stimulated, thereby promoting hair growth and hair fixation. Using the method and device of the present invention, treatment is carried out every week for several months, and the density of the user's hair can be greatly increased, thereby achieving the effect of promoting hair growth.
附图说明Description of the drawings
图1生发装置剖视结构图;Figure 1 is a sectional structural view of the hair growth device;
图2生发装置俯视结构图;Figure 2 is a top structural view of the hair growth device;
图例:1-头盔,2-保温层,3-温度传感器,4-排气单向阀,5-气体发生组件,6-除湿装置,7-温度控制系统,8-导热网,9-密封圈。Legend: 1-helmet, 2-insulation layer, 3-temperature sensor, 4-exhaust one-way valve, 5-gas generating component, 6-dehumidification device, 7-temperature control system, 8-heat conductive mesh, 9-sealing ring .
图3实施例3使用装置前后的效果图;Figure 3 is an effect diagram before and after using the device in Embodiment 3;
图4对比例2生发效果图。Figure 4 is a diagram of the hair growth effect of Comparative Example 2.
具体实施方式Detailed ways
为使本发明实施例的目的、技术方案和优点更加清楚,下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例是本发明一部分实施例,而不是全部的实施例。通常在此处附图中描述和示出的本发明实施例的组件可以以各种不同的配置来布置和设计。In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments These are some embodiments of the present invention, rather than all embodiments. The components of the embodiments of the invention generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations.
实施例中未注明的具体条件,通常按照常规条件以及手册中所述的条件,或按照制造厂商所建议的条件;所用的材料、组件等,如无特殊说明,均可从商业途径得到。Specific conditions not specified in the examples are usually based on conventional conditions and conditions described in the manual, or conditions recommended by the manufacturer; the materials, components, etc. used can be obtained from commercial sources unless otherwise specified.
应注意到:相似的标号和字母在下面的附图中表示类似项,因此,一旦某一项在一个附图中被定义,则在随后的附图中不需要对其进行进一步定义和解释。It should be noted that similar reference numerals and letters represent similar items in the following figures, therefore, once an item is defined in one figure, it does not need further definition and explanation in subsequent figures.
在本发明的描述中,需要说明的是,术语“中心”、“上”、“下”、“左”、“右”、“竖直”、“水平”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系,或者是该产品使用时惯常摆放的方位或位置关系,仅是为了便于描述本发明和简化描述,而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作,因此不能理解为对本发明 的限制。In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. The indicated orientation or positional relationship is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the product is customarily placed during use. It is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply what is meant. Refers to devices or elements that must have a specific orientation, be constructed and operate in a specific orientation, and therefore are not to be construed as limiting the scope of the invention. limits.
此外,术语“水平”、“竖直”、“悬垂”等术语并不表示要求部件绝对水平或悬垂,而是可以稍微倾斜。如“水平”仅仅是指其方向相对“竖直”而言更加水平,并不是表示该结构一定要完全水平,而是可以稍微倾斜。Furthermore, the terms "horizontal," "vertical," "overhanging," etc. do not imply a requirement that the component be absolutely horizontal or overhanging, but may be slightly tilted. For example, "horizontal" only means that its direction is more horizontal than "vertical". It does not mean that the structure must be completely horizontal, but can be slightly tilted.
在本发明的描述中,还需要说明的是,除非另有明确的规定和限定,术语“设置”、“安装”、“相连”、“连接”应做广义理解,例如,可以是固定连接,也可以是可拆卸连接,或一体地连接;可以是机械连接,也可以是电连接;可以是直接相连,也可以通过中间媒介间接相连,可以是两个元件内部的连通。对于本领域的普通技术人员而言,可以具体情况理解上述术语在本发明中的具体含义。In the description of the present invention, it should also be noted that, unless otherwise clearly stated and limited, the terms "set", "installation", "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, It can also be a detachable connection or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be an internal connection between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood on a case-by-case basis.
下面结合附图,对本发明的一些实施方式作详细说明。在不冲突的情况下,下述的实施例及实施例中的特征可以相互组合。Some embodiments of the present invention will be described in detail below with reference to the accompanying drawings. The following embodiments and features in the embodiments may be combined with each other without conflict.
实施例1Example 1
如图1和图2所示,本发明的装置包括适合人体佩戴的头盔1,头盔外表面具有保温层2,头盔1与具有弹性的密封圈9共同构建内部一个相对封闭的空腔;温度传感器3收集内部空腔温度以给空腔温度控制调节提供反馈信号;气体发生组件5内放置泡腾片和水,产生二氧化碳气体;单向阀4可将多余气体排出,维持内部腔体的正常气压;温度控制系统7为具有制冷功能的半导体制冷模块;可设置制冷温度,制冷模块与铜薄网片相连,铜薄网片覆盖空腔内表面。除湿装置6中为海绵,吸收装置运行时制半导体制冷模块产生的冷凝水珠。As shown in Figures 1 and 2, the device of the present invention includes a helmet 1 suitable for human body wear. The outer surface of the helmet has an insulation layer 2. The helmet 1 and an elastic sealing ring 9 jointly construct a relatively closed cavity inside; a temperature sensor 3. Collect the internal cavity temperature to provide feedback signals for cavity temperature control and adjustment; effervescent tablets and water are placed in the gas generating component 5 to generate carbon dioxide gas; the one-way valve 4 can discharge excess gas to maintain the normal air pressure of the internal cavity ; The temperature control system 7 is a semiconductor refrigeration module with a refrigeration function; the refrigeration temperature can be set, the refrigeration module is connected to a thin copper mesh, and the thin copper mesh covers the inner surface of the cavity. The dehumidification device 6 is a sponge that absorbs condensed water droplets generated by the semiconductor refrigeration module when the device is running.
实施例2气体发生组件对空腔温度均一性的影响实验Example 2 Experiment on the influence of gas generating components on cavity temperature uniformity
实施例1的装置使用时,将实施例1的装置的气体发生组件5中放置一片泡腾片和水(2ml),其中泡腾片为市售(主要成分包括柠檬酸、碳酸氢钠、乳糖、山梨糖醇、甜橙粉、维生素C)。盖好盖子,泡腾片和水产生二氧化碳气体,产生的二氧化碳气流推动装置内部空腔的气体流动,多余的气体从单向阀4排出。装置运行5分钟后,对内部空腔中氧气浓度进行探测,测得氧气浓度为0.9%。在前述装置启动的同时,将温度控制系统7同时启动,设定制冷温度10℃,待温度稳定后,维持5分钟,对空腔内顶部中心、左中、右中、后中、前中5个点温度进行监控,最高温度为10.6℃,最低9.5℃。When using the device of Example 1, place an effervescent tablet and water (2 ml) in the gas generating component 5 of the device of Example 1, where the effervescent tablet is commercially available (the main ingredients include citric acid, sodium bicarbonate, lactose , sorbitol, sweet orange powder, vitamin C). Cover the lid, and the effervescent tablets and water will generate carbon dioxide gas. The generated carbon dioxide gas flow will push the gas flow in the cavity inside the device, and the excess gas will be discharged from the one-way valve 4. After the device ran for 5 minutes, the oxygen concentration in the internal cavity was detected and the measured oxygen concentration was 0.9%. When the aforementioned device is started, start the temperature control system 7 at the same time, set the cooling temperature to 10°C, and maintain it for 5 minutes after the temperature stabilizes. The temperature of each point is monitored, with the highest temperature being 10.6℃ and the lowest temperature being 9.5℃.
实施例1的装置使用时,操作同前述,区别在于在前述温度控制系统启动的同时,将气体发生组件5关闭,设定制冷温度10℃,待温度稳定后,维持5分钟,对空腔内顶部中心、左中、右中、后中、前中5个点温度进行监控,最高温度为13.2℃,最低7.6℃。 When using the device of Embodiment 1, the operation is the same as above. The difference is that while the aforementioned temperature control system is started, the gas generating component 5 is closed, and the refrigeration temperature is set to 10°C. After the temperature stabilizes, it is maintained for 5 minutes, and the temperature in the cavity is The temperature is monitored at five points: top center, left center, right center, rear center, and front center. The highest temperature is 13.2°C and the lowest is 7.6°C.
另外,优选的,实施例1的装置使用时,将实施例1的装置气体发生组件5中放置固态二氧化碳干冰,盖好盖子,干冰通过吸收环境中热升华产生二氧化碳气体,产生的二氧化碳气流推动装置内部空腔的气体流动,多余的气体从单向阀4排出。装置运行5分钟后,对内部空腔中氧气浓度进行探测,测得氧气浓度为0.1%,表明二氧化碳气体有效地推动内部空气的流动,将原来的空气大部分排尽。In addition, preferably, when the device of Embodiment 1 is used, solid carbon dioxide dry ice is placed in the gas generating component 5 of the device of Embodiment 1, and the lid is closed. The dry ice generates carbon dioxide gas by absorbing thermal sublimation from the environment, and the generated carbon dioxide gas flow drives the device. The gas in the internal cavity flows, and the excess gas is discharged from the one-way valve 4. After the device ran for 5 minutes, the oxygen concentration in the internal cavity was detected and the measured oxygen concentration was 0.1%, indicating that carbon dioxide gas effectively promoted the flow of internal air and exhausted most of the original air.
在前述装置启动的同时,将温度控制系统7同时启动,设定制冷温度8℃,待温度稳定后,维持5分钟,对空腔内顶部中心、左中、右中、后中、前中5个点温度进行监控,最高温度为8.8℃,最低7.5℃。When the aforementioned device is started, start the temperature control system 7 at the same time, set the refrigeration temperature to 8°C, and maintain it for 5 minutes after the temperature stabilizes. The temperature at each point is monitored, with the highest temperature being 8.8°C and the lowest temperature being 7.5°C.
实施例1的装置使用时,操作同前述,区别在于在温度控制系统7装置启动的同时,将气体发生组件5关闭,设定制冷温度8℃,待温度稳定后,维持5分钟,对空腔内顶部中心、左中、右中、后中、前中5个点温度进行监控,最高温度为9.3℃,最低6.9℃。When using the device of Embodiment 1, the operation is the same as described above. The difference is that while the temperature control system 7 device is started, the gas generating component 5 is turned off, and the refrigeration temperature is set to 8°C. After the temperature is stabilized, it is maintained for 5 minutes and the cavity is The temperature is monitored at five points at the center of the inner top, left center, right center, rear center, and front center. The highest temperature is 9.3°C and the lowest is 6.9°C.
上述实验说明,气体发生组件中产生的二氧化碳气体有效地推动内部空气的流动,将原来的空气大部分排尽,实现低氧环境;同时,当温度控制系统运行时,同时运行气体发生组件,能够减小装置内的温度差,使空腔内温度更均一。The above experiments show that the carbon dioxide gas generated in the gas generating component effectively promotes the flow of internal air, exhausts most of the original air, and achieves a low-oxygen environment; at the same time, when the temperature control system is running and the gas generating component is operated at the same time, it can Reduce the temperature difference within the device and make the temperature in the cavity more uniform.
实施例3Example 3
具有雄性脱发症状的两例男性患者配戴好实施例1装置后,在气体发生组件中放置二氧碳干冰,盖好盖子。运行2分钟后,生发装置内部的氧气浓度探测结果为0.2%,设置温度为8℃,待显示温度降低到目标温度后维持5分钟,再将温度设置为16℃,温度到达设定值后维持5分钟,重复上述降温-升温的循环操作两次。每周一、三和五治疗一次,持续6个月,在0个月、4个月、5个月和6个月对同一区域的头发密度进行统计(如表1),6个月可观察到头发密度(根/cm2)分别提升了37%和25%。治疗整体效果见图3,从图中可以看出裸露的头皮减少,可明显看出发量的增加。After two male patients with symptoms of male alopecia put on the device of Embodiment 1, carbon dioxide dry ice was placed in the gas generating component and the lid was closed. After running for 2 minutes, the oxygen concentration detection result inside the hair growth device is 0.2%, and the set temperature is 8°C. After the displayed temperature drops to the target temperature, it is maintained for 5 minutes. Then the temperature is set to 16°C, and the temperature is maintained after the temperature reaches the set value. For 5 minutes, repeat the above-mentioned cooling-heating cycle twice. Treatment is performed once every Monday, Wednesday and Friday for 6 months. Statistics of hair density in the same area are performed at 0, 4, 5 and 6 months (as shown in Table 1). It can be observed at 6 months Hair density (roots/cm 2 ) increased by 37% and 25% respectively. The overall effect of the treatment is shown in Figure 3. From the picture, it can be seen that the exposed scalp is reduced and the hair volume is obviously increased.
表1治疗过程中头发密度的计数
Table 1 Count of hair density during treatment
对比例1Comparative example 1
具有雄性脱发症状的两例男性患者配戴好实施例1装置,仅开启温度控制系统,而不使用气体发生组件。降温-升温方式按照实施例3的方式进行。每周一、三和五治疗一次,持续6个月,在0个月、4个月、5个月和6个月对同一区域的头发密度进行统计(如表2),6个月可观察到头发密度(根/cm2)分别提升了10%和9%。Two male patients with symptoms of male pattern baldness put on the device of Embodiment 1 and only turned on the temperature control system without using the gas generating component. The cooling-heating method was carried out as in Example 3. Treatment is performed once every Monday, Wednesday and Friday for 6 months. Statistics of hair density in the same area are performed at 0, 4, 5 and 6 months (as shown in Table 2). It can be observed at 6 months Hair density (roots/cm 2 ) increased by 10% and 9% respectively.
表2治疗过程中头发密度的计数
Table 2 Count of hair density during treatment
对比例2Comparative example 2
具有雄性脱发症状的两例男性患者配戴好实施例1装置后,在气体发生组件中放置二氧碳干冰,盖好盖子。运行0.5分钟后,生发装置内部的氧气浓度探测结果为7%。每周一、三和五治疗一次,持续6个月,在0个月、4个月、5个月和6个月对同一区域的头发密度进行统计(如表3),6个月可观察到头发密度(根/cm2)分别提升了16.9%和9.4%。使用情况见图4,使用前(0天,左图)和使用后(180天,右图)可以看出,生发效果并不明显。After two male patients with symptoms of male alopecia put on the device of Embodiment 1, carbon dioxide dry ice was placed in the gas generating component and the lid was closed. After running for 0.5 minutes, the oxygen concentration detection result inside the hair growth device was 7%. Treatment is performed once every Monday, Wednesday and Friday for 6 months. Statistics of hair density in the same area are made at 0, 4, 5 and 6 months (as shown in Table 3). It can be observed at 6 months Hair density (roots/cm 2 ) increased by 16.9% and 9.4% respectively. The usage is shown in Figure 4. Before use (0 days, left picture) and after use (180 days, right picture), it can be seen that the hair growth effect is not obvious.
表3治疗过程中头发密度的计数
Table 3 Count of hair density during treatment
上述实验结果说明,本发明的方法通过周期性地降温-升温调控头皮表面温度,冷热刺激头 皮,同时降低周围环境的氧浓度,减少毛囊供血,提供持续的低氧,影响毛囊干细胞的代谢,代谢产物有利于增加毛囊干细胞的活性和寿命。通过冷热交替和低氧两者的协同作用,进一步刺激头皮的毛囊干细胞,从而促进毛发的生长同时具有固发的效果。The above experimental results show that the method of the present invention regulates the scalp surface temperature by periodically cooling and heating, and stimulates the scalp with hot and cold. It also reduces the oxygen concentration of the surrounding environment, reduces the blood supply to hair follicles, provides continuous low oxygen, affects the metabolism of hair follicle stem cells, and the metabolites are beneficial to increase the activity and lifespan of hair follicle stem cells. Through the synergistic effect of alternating hot and cold and hypoxia, the hair follicle stem cells of the scalp are further stimulated, thereby promoting hair growth and having a hair-fixing effect.
对比例1中仅采用单纯的降温-升温的控制,对头皮的毛囊刺激有限,生发效果并不理想;对比例2中虽然采用了系统降温-升温控制,可以刺激头皮,但是由于周围环境的氧浓度较高,毛囊细胞可以从空气获取氧气,此时毛囊干细胞代谢机制不同,无法有效刺激毛囊干细胞,从而无法发挥变温与低氧的协同作用,生发效果一般。因此,相较对比例1中只单纯的降温-升温控制和对比例2的高含氧环境,本发明具有更有效的生发效果。In Comparative Example 1, only simple cooling-heating control is used, which has limited stimulation of hair follicles on the scalp, and the hair growth effect is not ideal; in Comparative Example 2, although systematic cooling-heating control is used, it can stimulate the scalp, but due to the oxygen in the surrounding environment At a higher concentration, hair follicle cells can obtain oxygen from the air. At this time, the metabolic mechanism of hair follicle stem cells is different and the hair follicle stem cells cannot be effectively stimulated. Therefore, the synergistic effect of temperature change and hypoxia cannot be exerted, and the hair growth effect is average. Therefore, compared with the simple cooling-heating control in Comparative Example 1 and the high oxygen-containing environment in Comparative Example 2, the present invention has a more effective hair growth effect.
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。 The above are only preferred specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any person familiar with the technical field can, within the technical scope disclosed in the present invention, implement the technical solutions of the present invention. Equivalent substitutions or changes of the inventive concept thereof shall be included in the protection scope of the present invention.

Claims (15)

  1. 一种促进毛发生长的方法,其特征在于,使头皮处于封闭环境中,向封闭环境中通入气体,使封闭环境中的含氧量低于5%,降低封闭环境温度至-5~20℃,保持1~30min,升高封闭环境温度至15~30℃,保持1~30min。A method for promoting hair growth, which is characterized by placing the scalp in a closed environment, introducing gas into the closed environment, making the oxygen content in the closed environment less than 5%, and reducing the temperature of the closed environment to -5~20°C , keep for 1 to 30 minutes, raise the closed environment temperature to 15 to 30°C, and keep for 1 to 30 minutes.
  2. 如权利要求1所述的方法,其特征在于,所述含氧量低于3%,优选的,所述含氧量低于1.5%,更优选的,所述含氧量低于1%。The method of claim 1, wherein the oxygen content is less than 3%, preferably, the oxygen content is less than 1.5%, and more preferably, the oxygen content is less than 1%.
  3. 如权利要求1所述的方法,其特征在于,所述降低封闭环境温度的降温速率为0.1~20℃/min,优选为1~10℃/min。The method according to claim 1, characterized in that the cooling rate for reducing the temperature of the closed environment is 0.1-20°C/min, preferably 1-10°C/min.
  4. 如权利要求1所述的方法,其特征在于,所述方法中封闭环境中通入气体和降低封闭环境温度步骤同时或先后进行。The method according to claim 1, characterized in that in the method, the steps of introducing gas into the closed environment and reducing the temperature of the closed environment are performed at the same time or one after another.
  5. 如权利要求1所述的方法,其特征在于,所述气体选自二氧化碳、氢气、氮气、氦气和氩气中的一种或多种。The method of claim 1, wherein the gas is selected from one or more of carbon dioxide, hydrogen, nitrogen, helium and argon.
  6. 如权利要求1所述的方法,其特征在于,所述的降低封闭环境温度和升高封闭环境温度的过程重复2~8次,优选的,重复2~3次。The method according to claim 1, characterized in that the process of lowering the temperature of the closed environment and raising the temperature of the closed environment is repeated 2 to 8 times, preferably 2 to 3 times.
  7. 如权利要求1~6任一项所述的方法,其特征在于,所述方法中降低封闭环境温度至0~16℃,优选的,所述降低封闭环境温度至6~14℃;优选的,所述保持时间为2~20min,更优选的,所述保持时间为5~15min;优选的,所述升高封闭环境温度至20~25℃;优选的,所述保持时间为2~20min。The method according to any one of claims 1 to 6, characterized in that in the method, the temperature of the closed environment is reduced to 0-16°C, preferably, the temperature of the closed environment is reduced to 6-14°C; preferably, The holding time is 2 to 20 minutes, more preferably, the holding time is 5 to 15 minutes; preferably, the closed environment temperature is raised to 20 to 25°C; preferably, the holding time is 2 to 20 minutes.
  8. 如权利要求1所述的方法,其特征在于,升高封闭环境温度选自自然升温、通入气体升温或加热升温。The method according to claim 1, characterized in that increasing the temperature of the closed environment is selected from the group consisting of natural heating, gas heating or heating.
  9. 一种促进毛发生长的装置,其特征在于,所述装置包括:头盔、温度控制系统和气体发生组件;A device for promoting hair growth, characterized in that the device includes: a helmet, a temperature control system and a gas generating component;
    所述头盔设置有适于头部佩戴的空腔,所述的空腔底部设置有密封圈,用于使头皮处于封闭环境;The helmet is provided with a cavity suitable for being worn on the head, and a sealing ring is provided at the bottom of the cavity to keep the scalp in a closed environment;
    所述头盔上设置有单向阀,所述的单向阀用于排除头盔内的气体;The helmet is provided with a one-way valve, and the one-way valve is used to eliminate gas in the helmet;
    所述头盔上设置有温度控制系统;The helmet is provided with a temperature control system;
    所述气体发生组件用于向封闭环境中通入气体;The gas generating component is used to introduce gas into the closed environment;
    其中,所述气体发生组件设置在头盔上,通过气体管路通向头盔内部,或者,所述气体发生组件与头盔通过气体管路相连,所述的气体管路通向头盔内部。Wherein, the gas generating component is arranged on the helmet and leads to the inside of the helmet through a gas pipeline, or the gas generating component is connected to the helmet through a gas pipeline, and the gas pipeline leads to the inside of the helmet.
  10. 如权利要求9所述的装置,其特征在于,所述装置还包括温度均衡组件,使空腔内温 度均一,优选的,所述的温度均衡组件为设置在头盔内部的导热网或导热片,所述的导热网或导热片与温度控制系统相连;更优选的,所述导热网或导热片的材料选自金属;特别优选的,所述的金属选自铝、镁、铁、铜、金、银、镍或合金。The device according to claim 9, characterized in that the device further includes a temperature equalization component to make the temperature inside the cavity The temperature is uniform. Preferably, the temperature balancing component is a heat-conducting net or heat-conducting sheet arranged inside the helmet, and the heat-conducting net or heat-conducting sheet is connected to the temperature control system; more preferably, the heat-conducting net or heat-conducting sheet is The material is selected from metals; particularly preferably, the metal is selected from aluminum, magnesium, iron, copper, gold, silver, nickel or alloys.
  11. 如权利要求9或10所述的装置,其特征在于,所述温度控制系统包括制冷组件,所述制冷组件为半导体制冷器;优选的,所述半导体制冷器的设置数量为1~10个,更优选为1~5个。The device according to claim 9 or 10, characterized in that the temperature control system includes a refrigeration component, and the refrigeration component is a semiconductor refrigerator; preferably, the number of the semiconductor refrigerators is 1 to 10, More preferably, they are 1 to 5.
  12. 如权利要求9所述的装置,其特征在于,气体发生组件包括气体发生腔,所述的气体发生腔用于气体的产生。The device according to claim 9, wherein the gas generating component includes a gas generating chamber, and the gas generating chamber is used for generating gas.
  13. 如权利要求11所述的装置,其特征在于,所述装置还包括除湿组件,所述除湿组件与头盔相连接,用于消除制冷组件工作时产生的冷凝水;优选的,所述除湿组件包括干燥剂或吸水海绵。The device according to claim 11, characterized in that the device further includes a dehumidification component, the dehumidification component is connected to the helmet and is used to eliminate condensed water generated when the refrigeration component is working; preferably, the dehumidification component includes Desiccant or absorbent sponge.
  14. 如权利要9所述的装置,其特征在于,所述装置包含温度传感器,所述温度传感器设置在头盔内侧,监测空腔温度。The device according to claim 9, characterized in that the device includes a temperature sensor, and the temperature sensor is arranged on the inside of the helmet to monitor the temperature of the cavity.
  15. 如权利要求9~14任一项所述的装置在美容领域中的应用;优选的,所述美容包括:预防和/或治疗脱发、体毛稀少;更优选的,所述脱发包括:雄激素性脱发和/或化疗所导致的脱发。 The application of the device according to any one of claims 9 to 14 in the field of beauty; preferably, the beauty treatment includes: prevention and/or treatment of hair loss and sparse body hair; more preferably, the hair loss includes: androgenic Alopecia and/or hair loss due to chemotherapy.
PCT/CN2023/081967 2022-03-16 2023-03-16 Method and device for promoting growth of hair WO2023174379A1 (en)

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