WO2023141560A3 - Alkaline phosphatase for use in oncology - Google Patents
Alkaline phosphatase for use in oncology Download PDFInfo
- Publication number
- WO2023141560A3 WO2023141560A3 PCT/US2023/060978 US2023060978W WO2023141560A3 WO 2023141560 A3 WO2023141560 A3 WO 2023141560A3 US 2023060978 W US2023060978 W US 2023060978W WO 2023141560 A3 WO2023141560 A3 WO 2023141560A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oncology
- cancer therapy
- alkaline phosphatase
- iap
- laps
- Prior art date
Links
- 102000002260 Alkaline Phosphatase Human genes 0.000 title 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 title 1
- 102100024319 Intestinal-type alkaline phosphatase Human genes 0.000 abstract 2
- 238000011275 oncology therapy Methods 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 101710184243 Intestinal-type alkaline phosphatase Proteins 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present disclosure relates, inter alia, to combination therapies of specific commensal gastrointestinal bacteria with therapeutic intestinal alkaline phosphatases (lAPs) for preventing, treating, and/or reducing a cancer therapy-mediated side effect, or improving efficacy of a cancer therapy relative to the treatment before or in the absence of IAP.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202263301227P | 2022-01-20 | 2022-01-20 | |
US63/301,227 | 2022-01-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2023141560A2 WO2023141560A2 (en) | 2023-07-27 |
WO2023141560A3 true WO2023141560A3 (en) | 2023-09-21 |
Family
ID=87349170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2023/060978 WO2023141560A2 (en) | 2022-01-20 | 2023-01-20 | Alkaline phosphatase for use in oncology |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2023141560A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024036144A1 (en) * | 2022-08-09 | 2024-02-15 | Theriva Biologics, Inc. | Treatment or prevention of gastrointestinal immunotherapy side effects |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020106983A1 (en) * | 2018-11-21 | 2020-05-28 | Board Of Regents, The University Of Texas System | Methods and compositions for treating cancer |
WO2020163381A1 (en) * | 2019-02-04 | 2020-08-13 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Compositions and methods to detect gastrointestinal disease |
US20200277379A1 (en) * | 2019-03-01 | 2020-09-03 | Rampart Health, L.L.C. | Pharmaceutical composition combining immunologic and chemotherapeutic method for the treatment of cancer |
WO2020247421A1 (en) * | 2019-06-03 | 2020-12-10 | Synthetic Biologics, Inc. | Alkaline phosphatase formulations and uses thereof |
-
2023
- 2023-01-20 WO PCT/US2023/060978 patent/WO2023141560A2/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020106983A1 (en) * | 2018-11-21 | 2020-05-28 | Board Of Regents, The University Of Texas System | Methods and compositions for treating cancer |
WO2020163381A1 (en) * | 2019-02-04 | 2020-08-13 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Compositions and methods to detect gastrointestinal disease |
US20200277379A1 (en) * | 2019-03-01 | 2020-09-03 | Rampart Health, L.L.C. | Pharmaceutical composition combining immunologic and chemotherapeutic method for the treatment of cancer |
WO2020247421A1 (en) * | 2019-06-03 | 2020-12-10 | Synthetic Biologics, Inc. | Alkaline phosphatase formulations and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2023141560A2 (en) | 2023-07-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2019220369A3 (en) | Methods of treating cancers and enhancing efficacy of t cell redirecting therapeutics | |
MX2020008777A (en) | Microbiome related immunotherapies. | |
WO2023141560A3 (en) | Alkaline phosphatase for use in oncology | |
MXPA05011656A (en) | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. | |
IL171607A (en) | Use of a botulinum toxin for the preparation of a medicament for treating sinus headache | |
EA201650134A1 (en) | SPECIFIC COMBINED THERAPY OF MALIGNANT TUMORS BY CYTOSTATIC AND ITS MODIFIER | |
MX2023004156A (en) | Combination therapy for treating cancer. | |
NZ588435A (en) | Use of a polypeptide with an angiotensin-converting enzyme 2 (ACE2) activity for treating tumours (with the exception of lung cancer) | |
IL155781A0 (en) | Effective antitumor treatments | |
MX2009011320A (en) | Enzymatic anticancer therapy. | |
WO2018102687A3 (en) | Combination therapy for treating cancer | |
MX2023006793A (en) | Combination therapies for treatment of her2 cancer. | |
ZA202300875B (en) | Kat6 inhibitor methods and combinations for cancer treatment | |
MX2021008972A (en) | Metal chelator combination therapy for the treatment of cancer. | |
PH12020551176A1 (en) | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent | |
UA86586C2 (en) | Combination for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis | |
MX2020008881A (en) | Methods of treatment of cancer comprising chk1 inhibitors. | |
WO2021229507A3 (en) | Methods, therapies and uses for treating cancer | |
MX2022011845A (en) | Combination therapy with a mutant idh inhibitor and a bcl-2 inhibitor. | |
MX2022014223A (en) | Combination therapy for ttr amyloidosis. | |
TW200724158A (en) | Combination therapy in the treatment of cancer | |
AU2020327022A8 (en) | Method of treating cancer | |
MX2021006778A (en) | Novel approach for treatment of cancer using immunomodulation. | |
WO2023164455A3 (en) | Compositions and methods to modulate the immune system | |
MX2021002884A (en) | Combination therapy for the treatment of prostate cancer. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 23743945 Country of ref document: EP Kind code of ref document: A2 |