WO2023138433A3 - Composé amide ayant une activité inhibitrice de ripk1, son procédé de préparation et son utilisation - Google Patents

Composé amide ayant une activité inhibitrice de ripk1, son procédé de préparation et son utilisation Download PDF

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Publication number
WO2023138433A3
WO2023138433A3 PCT/CN2023/071413 CN2023071413W WO2023138433A3 WO 2023138433 A3 WO2023138433 A3 WO 2023138433A3 CN 2023071413 W CN2023071413 W CN 2023071413W WO 2023138433 A3 WO2023138433 A3 WO 2023138433A3
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WIPO (PCT)
Prior art keywords
amide compound
ripk1
preparation
inhibitory activity
method therefor
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PCT/CN2023/071413
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English (en)
Chinese (zh)
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WO2023138433A2 (fr
Inventor
段文虎
耿美玉
张贺峰
艾菁
金泽宸
季寅淳
冯大智
彭霞
方晨
戴阳
兰垚瀚
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中国科学院上海药物研究所
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Publication of WO2023138433A2 publication Critical patent/WO2023138433A2/fr
Publication of WO2023138433A3 publication Critical patent/WO2023138433A3/fr

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

L'invention concerne un composé amide ayant une activité inhibitrice de RIPK1, son procédé de préparation et son utilisation. La structure du composé amide est représentée dans la formule générale I, et les définitions des substituants sont telles que décrites dans la description et les revendications. Le composé amide de la présente invention peut être utilisé pour le traitement de troubles et de maladies liés à RIPK1, tels que des maladies inflammatoires, des maladies ischémiques, des maladies neurodégénératives et des tumeurs.
PCT/CN2023/071413 2022-01-21 2023-01-09 Composé amide ayant une activité inhibitrice de ripk1, son procédé de préparation et son utilisation WO2023138433A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202210074243 2022-01-21
CN202210074243.4 2022-01-21

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WO2023138433A2 WO2023138433A2 (fr) 2023-07-27
WO2023138433A3 true WO2023138433A3 (fr) 2023-08-31

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CN (1) CN116478135A (fr)
WO (1) WO2023138433A2 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110272426A (zh) * 2018-07-17 2019-09-24 深圳市塔吉瑞生物医药有限公司 用于抑制蛋白激酶活性的炔基（杂）芳环类化合物
CN111100130A (zh) * 2018-10-29 2020-05-05 四川大学 4-氨基吡咯并嘧啶衍生物及其制备方法和用途
WO2020151589A1 (fr) * 2019-01-25 2020-07-30 北京赛特明强医药科技有限公司 Composé hétérocyclique à pont acylamino, composition et utilisation associées
KR20200134370A (ko) * 2019-05-21 2020-12-02 주식회사 비투에스바이오 N-(3-(이미다조[1,2-b]피리다진-3-일에틴일)페닐)카복스아미드 유도체 및 이를 유효성분으로 포함하는 키나아제 관련 질환 치료용 약학적 조성물
WO2021046515A1 (fr) * 2019-09-06 2021-03-11 Board Of Regents, The University Of Texas System Inhibiteurs de la protéine kinase i interagissant avec le récepteur pour le traitement d'une maladie
WO2021108198A1 (fr) * 2019-11-26 2021-06-03 Board Of Regents, The University Of Texas System Inhibiteurs de la protéine kinase 1 interagissant avec les récepteurs pour le traitement d'une maladie

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110272426A (zh) * 2018-07-17 2019-09-24 深圳市塔吉瑞生物医药有限公司 用于抑制蛋白激酶活性的炔基（杂）芳环类化合物
CN111100130A (zh) * 2018-10-29 2020-05-05 四川大学 4-氨基吡咯并嘧啶衍生物及其制备方法和用途
WO2020151589A1 (fr) * 2019-01-25 2020-07-30 北京赛特明强医药科技有限公司 Composé hétérocyclique à pont acylamino, composition et utilisation associées
KR20200134370A (ko) * 2019-05-21 2020-12-02 주식회사 비투에스바이오 N-(3-(이미다조[1,2-b]피리다진-3-일에틴일)페닐)카복스아미드 유도체 및 이를 유효성분으로 포함하는 키나아제 관련 질환 치료용 약학적 조성물
WO2021046515A1 (fr) * 2019-09-06 2021-03-11 Board Of Regents, The University Of Texas System Inhibiteurs de la protéine kinase i interagissant avec le récepteur pour le traitement d'une maladie
WO2021108198A1 (fr) * 2019-11-26 2021-06-03 Board Of Regents, The University Of Texas System Inhibiteurs de la protéine kinase 1 interagissant avec les récepteurs pour le traitement d'une maladie

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