WO2023135038A1

WO2023135038A1 - Secure blood sampler on extracorporeal circuit

Info

Publication number: WO2023135038A1
Application number: PCT/EP2023/050070
Authority: WO
Inventors: Angeline PENA PRADO
Original assignee: Pena Prado Angeline
Priority date: 2022-01-11
Filing date: 2023-01-03
Publication date: 2023-07-20
Also published as: FR3131684A1

Abstract

The invention relates to a device for collecting a sample from a septum (100), said device comprising a hollow body (4) that receives a needle (2) securely mounted on a support (20), and comprising an internal reservoir (3) connected to said needle (2), which needle is oriented towards a first end (40) of said body (4), and comprising grasping means (5) located at an opposite end of said body (4). The invention is characterised in that at least said support (20) is placed inside said body (4), said needle (2) being entirely contained within said body (4), which comprises, at the first end (40) thereof, an open recess (41) forming an internal space for receiving said septum (100), said needle (2) communicating with said internal space of said recess (41). The invention also relates to the use of said sampling device (1) for collecting a sample from a septum (100), advantageously for measuring and quantifying a compound present in said collected sample.

Description

SAFE BLOOD SAMPLER ON EXTRA-BODY CIRCUIT

TECHNICAL AREA

The present invention relates to a medical device and its use in vitro in the examination of samples of fluids from the human body, in particular blood samples.

PRIOR TECHNIQUE

The present invention falls within the medical field of taking samples of bodily fluids, in particular blood samples.

The invention will find a preferential, but in no way limiting, application in the in vitro measurement and quantification of a compound present in said sample taken, such as the blood sugar level.

For example, patent document WC03/020134 is known, which discloses a device and a method for sampling a bodily fluid by sampling by absorption. The incision stylet more particularly described comprises a hollow longitudinal body, of generally cylindrical shape, forming a casing, inside which is positioned in particular an incision member in the form of a solid needle mounted inside a channel in the form of a capillary tube, channel which allows the transfer of fluid, in particular migration by capillarity, to an opening made in said body. This document thus aims at a superficial sampling, directly in external contact with the skin, the support of the solid needle serving only as a support for the needle, with a space for receiving the fluid sampled on the side of said needle, which does not communicate not with the tank.

Similarly, patent document WO99/55232 is known, which relates to a device for sucking and pumping a sample of bodily fluid from an incision, in the form of a stylet provided with a solid needle, to incise the skin at the surface, in order to to bring out a sample of body fluid. The needle mounted on a movable support is slidable by means of a piston actuated from the opposite end, from an inactive position to an active position protruding inside a housing provided within the distal end , with an elastic return by springs to the inactive position and allows pumping, via a trigger connected to a piston, to expel more fluid from the incision once made.

However, the invention is preferentially aimed at taking samples from a septum. Such a septum can be present on an extracorporeal circuit, or connected to another medical system, such as for example a urinary catheter.

Recall, within the meaning of the present invention, the term "septum" corresponds to a self-sealing membrane, generally made of silicone material, hermetically separating and preserving from the outside atmosphere, the interior of a circuit connected to the human body. , especially to its vascular system. The material and thickness of such a septum allow it to be pierced by a needle, and above all to retain its hermetic character once the needle is removed. Thus, it is possible in an aseptic manner to administer solutions and, more particularly, to take samples, in particular blood samples.

Such a septum can be mounted along an extracorporeal circuit in the form of sheaths, or else directly at one end of a catheter.

In this context, currently, the blood sample, of several milliliters, from an extracorporeal circuit is carried out by a carer by means of a needle mounted on a syringe. It may be a transfer trocar, commonly referred to as a "pink trocar" (because of its distinctive color differentiating the use for sampling, compared to other colors intended for injection), or even " trocar G18” (with regard to the dimensions of its gauge, i.e. the unit expressing the external diameter of a medical device). It can also be an “orange” needle, also referred to as a “G25 needle”.

Once the sample has been taken by piercing the septum, the caregiver deposits a droplet of blood on a suitable support, such as a blood glucose test strip intended to be analyzed in vitro by a dedicated device.

Such a practice presents significant risks for both the caregiver and the patient.

First of all, for the carer, there is a risk of breaking the skin by pricking himself with the protruding needle, during its manipulation, in particular when the needle must be uncapped manually, or after the sample is taken when it is pier. It is also possible to accidentally prick the patient.

Furthermore, when depositing the droplet of blood, especially by means of a syringe, there is a risk of blood splashing, in particular in contact with mucous membranes, such as the eyes, liable to induce contamination.

There is also a septic risk for the patient with the sampling needle which can touch surfaces and become contaminating.

This medical gesture therefore presents a manifest lack of safety for the carer, without ensuring the asepsis of such a medical gesture with any certainty.

In addition, the quantity of blood taken, several milliliters (symbol “ml”), is much greater than the real needs for the measurements and quantifications envisaged, namely a single drop of blood of the order of 1/20 ml.

DISCLOSURE OF THE INVENTION

The object of the invention is to overcome the drawbacks of the state of the art by proposing a device for taking a sample from a septum. Such a sampling device is intended to be able to ensure safety avoiding any risk of involuntary puncture and septic contamination, by means of a needle provided retracted inside a body of said sampling device. In addition, the needle is movably mounted from an inactive position enclosed inside said body, to a protruding active position with a view to taking the sample, while still being entirely contained in said body, and vice versa.

To do this, the sampling device comprises:

- a needle provided hollow, in the form of a tube, mounted for fixing on a support,

- an internal reservoir connected to said needle, said internal reservoir comprising walls delimiting a planned interior volume communicating with the needle,

- a hollow body receiving said support and said reservoir, said needle being oriented towards a first end of said body,

- Gripping means located at an opposite end of said body.

Advantageously, said sampling device is characterized in that at least:

- said support is placed inside said body, said needle being entirely contained inside said body, and

- said body comprising at its first end, an open housing, said housing providing an interior space for receiving said septum, said needle communicating with said interior space of said housing.

According to additional, non-limiting features, said support is mounted to move relative to said body, from an inactive position of said retracted needle relative to said housing, to an active position protruding inside the interior volume of said housing, and vice versa.

According to one embodiment, said support is slidably mounted inside said body, said support being actuated by movement in support of said gripping means provided movable with respect to said opposite end of said body, the movement of said gripping means being operating simultaneously by applying a pressure against said opposite end and a traction of said gripping means towards said opposite end, relatively to one another.

According to one embodiment, said reservoir forms said opposite end of said sampling device.

According to one embodiment, said sampling device comprises a member mounted inside said reservoir, like a piston actuated by said gripping means.

According to one embodiment, said sampling device comprises elastic return means from the active position to the inactive position.

According to one embodiment, said body comprises a window, while said reservoir comprises a through orifice, said window and said orifice being located opposite each other in the active position or in the inactive position. In addition, in the protruding position, the needle communicates with a reservoir making it possible to recover a dedicated quantity of the sample taken, said reservoir being accessible by a window made through said body. This communication makes it possible to avoid any risk of contact for the caregiver with the sample taken, as well as to prevent any external contamination.

The invention also relates to the use of the sampling device according to the invention, for taking a sample from a septum present on an extracorporeal circuit or on another medical system, such as a probe, preferably, for measuring and quantifying a compound present in said sample taken, more preferably to measure the blood sugar level.

In particular, the invention relates to the use of the sampling device to collect a sample of bodily fluid from a septum.

According to one non-limiting embodiment, the invention relates to the use for taking a blood sample from a septum present on an extracorporeal circuit.

According to one embodiment, the use aims to measure and quantify a compound present in said blood sample taken.

According to one embodiment, the use aims to measure the blood sugar level in said blood sample taken.

According to another embodiment, the use aims to measure the level of hemoglobin in said blood sample taken.

Thus, the sampling device according to the invention improves the care of patients, by promoting a clean and sterile medical procedure, without any risk of accident, including for the caregiver, avoiding for example the risks of injection or projection of Accidents of Exposure to Viruses (AEV) or Accidents of Exposure to Blood (AES).

In addition, in the context of a sample with a view to quantifying glycaemia, the invention complies with the standards in force relating to capillary and arterial glycaemia, authorizing the use of capillary and arterial glycaemia diagnostic apparatus.

BRIEF DESCRIPTION OF THE DRAWINGS

Other characteristics and advantages of the invention will emerge from the detailed description which will follow of the non-limiting embodiments of the invention, with reference to the appended figures, in which:

[Fig. 1] schematically represents a perspective view of an embodiment of a sampling device according to the invention, in the active position, showing in particular a slot made in the body of said device;

[Fig. 2] schematically represents a perspective view of another embodiment of said sampling device, in the inactive position;

[Fig. 3] schematically represents an exploded perspective view of FIG. 2, showing in particular the different parts of said sampling device; [Fig.4] schematically represents a view according to a longitudinal median section of an embodiment of the sampling device, showing in a partially exploded manner the various separate elements of said sampling device;

[Fig. 5] schematically represents a view according to a longitudinal median section of an embodiment of the sampling device, in the inactive position;

[Fig. 6] schematically represents a view similar to FIG. 4, in the active position; And

[Fig. 7] schematically represents a simplified view along a longitudinal median section of said sampling device, in the active position in cooperation with a septum of an extracorporeal circuit, showing in particular the flow of blood from said circuit to a reservoir.

DESCRIPTION OF EMBODIMENTS

The invention relates to a device 1 for taking a sample of bodily fluid, in particular a blood sample, also called a “sampler”.

The invention specifically relates to a sampling device 1 made from a septum 100. Such a septum 100 equips a medical system, such as an extracorporeal circuit 101, or even a probe, as mentioned above. Such a septum 100 is visible in the implementation example of Figure 7.

Advantageously, the sampling device 1 comprises a needle 2 fixedly mounted on a support 20. The needle 2 is therefore secured to its support 20.

More specifically, in a non-limiting manner, the needle 2 is mounted on one face of the support 20, called the "lower face" with respect to the orientation of the sampling device 1 during its use, namely downwards reference to Figures 4 to 7. The needle 2 is hollow, in the form of a tube. The needle 2 projects in relation to this lower face and passes through the wall of said lower face. The protruding end 200 of said needle 2 comprises a bevel, giving it a piercing or piercing capacity. The opposite end 201 of the needle 2 therefore opens out on the other side of the support 20 with respect to the lower face, namely on the side of the so-called “upper” face.

Said needle 2 can be of any type, preferably hypodermic, suitable for taking samples. According to one embodiment, the needle 2 is identical to that of a transfer trocar or "trocar" or even "trocar", commonly referred to as "pink trocar" (due to its distinctive color differentiating the use for sampling , compared to other colors intended for injection), or even "trocar G18" (with regard to the dimensions of its gauge, namely the unit expressing the external diameter of a medical device).

According to another particularly preferred embodiment, the needle 2 is identical to that of an “orange needle”, also designated “G25 needle”. According to another particularly preferred embodiment, the needle 2 is a heparinized or anti-coagulated needle, making it possible to leave the device 1 in place for a few hours for secure sampling on the extracorporeal circuit.

Furthermore, said support 20 can have any shape. According to the embodiment visible in the figures, said support 20 preferably has a generally cylindrical shape, with a circular section. The underside has a recess 21, within which the needle 2 is sealed over part of its length, ensuring its maintenance.

According to one embodiment, the needle 2 and its support 20 form a non-removable tip with respect to the sampling device 1, for single use.

According to another embodiment, the needle 2 and its support 20 form a removable tip relative to the sampling device 1, allowing it to be replaced for and according to each use.

The sampling device 1 also comprises an internal reservoir 3, provided for collecting the sample taken. To do this, the internal reservoir 3 is connected to said needle 2.

More specifically, in a non-limiting manner, said internal reservoir 3 comprises walls delimiting an interior volume 30 provided communicating with the needle 2. In particular, the opposite end 201 of the needle 2 is connected to the interior volume 30 of said reservoir 3 via a channel 31 formed within the corresponding wall of said reservoir 3, namely the wall located on the side of said end piece (needle 2 and support 20), or even the wall located below. In addition, the inside of the channel 31 is sized to receive said end 201 of the needle 2, namely with an internal diameter greater than or substantially equal to the clearance with respect to the external diameter of the said needle 2.

According to one embodiment, particularly visible in Figures 4 to 7, the reservoir 3 comprises a distal part 32 shaped to cooperate in interlocking with a complementary space 22 formed within said support 20. Thus, the support 20 can be engaged on the reservoir 3, ensuring a removable maintenance of one relative to the other, as well as the connection of the needle 2 to the interior volume 30 for the circulation of the fluid of the sample.

Further, the sampling device 1 comprises a hollow body 4 receiving said support 20 and said reservoir 3. In addition, the shape and internal dimensions of said body 4 are provided to be complementary, with respect to the external dimensions of said reservoir 3, as well as the tip.

Said body 4 can have any shape, preferably a cylindrical shape. The body 4 has an opening at its opposite end, namely the upper or upward end. This opening allows the insertion of the other elements inside the sampling device 1 .

Furthermore, once positioned inside, said needle 2 is oriented towards a first end 40 of said body 4, namely its lower end or located downwards. In other words, the insertion of the reservoir 3 and of the tip is carried out in such a way as to orient the pointed end 200 of the needle 2 towards said first end 40.

According to an advantageous characteristic, the sampling device 1 provides at least that when said support 20 is placed inside said body 4, said needle 2 is entirely contained inside said body 4. In short, no part of the needle 2 does not protrude beyond the walls delimiting said body 4, in particular its sharp end 200 . Thus, it is not possible for a user to prick himself inadvertently, ensuring a clean and sterile medical procedure, without any risk of accident, for the caregiver as for the patient.

Further, the sampling device 1 comprises gripping means 5 located at an opposite end of said body 4. Said gripping means 5, located on the proximal side of the body 4, allow the carer to hold it in the hand for the purpose of use of the sampling device 1.

Said gripping means 5 can have any shape. As visible in the embodiment of Figure 2, the gripping means 5 may be in the form of a simple ring, while they may include fins 50, as visible in the embodiment of Figure 1 .

According to an advantageous characteristic, the sampling device 1 provides at least that said body 4 comprises at its first end 40, an open housing 41 . In addition, said housing 41 provides an interior space for receiving said septum 100. In other words, said housing 41 has a shape complementary to that of septum 100, namely preferably globally cylindrical. In addition, the internal dimensions of the housing 41 are shaped complementary to the external dimensions of said septum 100, so as to allow the positioning of the sampling device 1 on the septum 100, including said septum 100 partially within said housing 41, in the body 4. Such a configuration of the sampling device 1 on the septum 100 is particularly visible in Figure 7.

In addition, said needle 2 communicates with said interior space of said housing 41. In short, housing 41 comprises a passage allowing needle 2, in particular its piercing end 200, to penetrate inside.

Such a passage can be in the form of a hole 42 provided passing through, through the bottom 43 of said housing 41. In addition, said hole 42 is shaped complementary to receive the end piece, in particular the step 21 of the support 20 located inside said body 4.

Thus, the needle 2 communicating inside the housing 41, said needle 2 can perforate the septum 100 introduced within said housing 41, until it reaches the inside of the extracorporeal circuit 101, allowing the fluid from the sample to circulate to the internal volume 30 of said reservoir 3, as can be seen in particular in FIG. 7. According to a preferred embodiment, said support 20 is mounted to move relative to said body 4, from an inactive position of said needle 2 retracted relative to said housing 41, to a protruding active position inside the interior volume of said housing 41, and vice versa. In short, said support 20 moves inside body 4, along a stroke extending from said inactive position to said active position.

In addition, in the inactive position, as seen in the example of Figure 5, the perforating end 200 is essentially contained inside the hole 42 passing through the housing 41, its tip being flush with said bottom 43. Due to the dimensions of said housing 41, it is then not possible to inadvertently introduce therein a body part capable of entering it, such as the distal phalanx of a finger.

In the active position, as seen in the example of Figure 6, the needle 2 is deployed, but still contained inside the body 4, not protruding outside the housing 41. It is then not possible to inadvertently pricking a predominantly flat body part, such as the caregiver's or patient's skin.

According to one embodiment, said support 20 is slidably mounted inside said body 4. In fact, as the end piece is mounted on reservoir 3, said reservoir 3 is jointly slidably mounted inside said body 4 .

In particular, the external dimensions of said reservoir 3 correspond, except for clearance, to the internal dimensions of said body 4, ensuring a sliding of one relative to the other. In short, said body 4 forms a guide sleeve in translation of said tank 3 in its stroke, namely a downward vertical translation from the inactive position to the active position (from top to bottom), and conversely an upward vertical translation from the active position to inactive position (from bottom to top).

Further on, the actuation of the sampling device 1 is carried out by pressing on the reservoir 3, making it possible to manually move the support 20 together from the inactive position to the active position.

According to one embodiment, this support can be conferred by the application of the sampling device 1 in contact with the septum 100, at the time of its insertion into said housing 41 . In short, the septum 100 forms an abutment at the time of application of said sampling device 1, blocking the body 4, only allowing said reservoir 3 to move under the action of said pressure.

Preferably, said support 20 is actuated by movement in support of said gripping means 5 provided to be movable with respect to the opposite end of said body 4.

In addition, said gripping means 5 are moved simultaneously by applying pressure against said opposite end and pulling said gripping means 5 towards said opposite end, relatively to one another. other. In short, a pinching gesture between the gripping means 5 and the opposite end of said body 4, reflects a thrust bearing against the reservoir 3, which then moves in translation from the inactive position to the active position. According to one embodiment, said reservoir 3 forms said opposite end of said sampling device 1, namely the upper end or located upwards. In short, reservoir 3 protrudes from body 4 at this upper end.

In particular, as can be seen in the figures, the sampling device 1 comprises a cover 6 ensuring the closure of the body 4, in particular by covering the corresponding end of the said reservoir 3. It is then advantageously against the said cover 6 that the support takes place, as well as possibly the pinching of said gripping means 5.

Such a cover 6 can have any shape, in particular an ergonomic shape, for example with a concave outer face, allowing in particular the support of the pulp of the thumb, while the rest of the body 4, in particular the gripping means 5, are held by the other fingers of the caregiver's hand.

Further forward, the gripping means 5 may have a vertical section generally shaped like a T, with side branches 51 connected to a middle part 52. Therefore, the tank 3 internally receives the means 5 for gripping.

In addition, the tank 3 laterally comprises perforated walls 33, allowing the movement of the side branches 51 of the gripping means 5. Such perforated walls 33 are provided in a complementary manner with respect to said branches 51, allowing their vertical movement during the movement induced on said means 5 for gripping.

According to one embodiment, the sampling device 1 comprises a member 7 mounted inside said reservoir 3, like a piston actuated by said gripping means 5 . The member 7 is therefore movable relative to said reservoir 3, in particular according to a vertical translation.

In addition, the member 7 can have any shape, in particular a cylindrical shape with a generally U-shaped vertical section, additionally to receive internally the middle part 52 of said means 5 for gripping.

Further forward, the member 7 may comprise a ring 70, ensuring its closure in the open upper part of its U-shape. This ring 70 fits over the distal ends of the branches of the U-shape.

In addition, said ring 70 is crossed by the middle part 52 of the gripping means 5, while the branches 51 remain outside.

According to a preferred embodiment, the ring 70 has an annular shape with an oblong hole, allowing the passage of the distal end of the middle part 52, shaped complementary with a lug 53. This lug 53 projects laterally, on both sides. other side of said middle portion 52.

Thus, combined with the complementary oblong hole of the ring 70, the shape of the lug 53 ensures, according to an angular configuration, the insertion of the middle part 52 inside said member 7, as well as its locking according to another angular configuration. , like a foolproof device. In said other angular configuration, the means 5 of grip therefore find themselves entangled with the member 7, the lug 53 being retained by the underside of said ring 70, preventing their disassembly of these elements one by the other. This other configuration nevertheless allows the sliding of the middle part 52 and therefore of the gripping means 5 with respect to the member 7. In particular, as can be seen in the example of FIG. 5, in the inactive position, the gripping means 5 are in the low position, the middle part 52 being found in abutment in the bottom of said member 7, while after pressing, in the active position, the lug 53 comes into abutment against the ring 70, as visible in the example of the figure 6. At this moment, the member 7 moves within the reservoir 3, applying a positive pressure to the fluid of the sample taken, due to the joint movement of the needle 2. This is how the movements of all of these elements are similar to the operation of a piston.

In particular, the piston effect makes it possible to create a positive pressure within the reservoir 3, which is necessary at the start of sampling when the needle 2 is plunged through the septum 100, to attract the fluid, for example blood, towards the tank 3.

Further, the return from the active position to the inactive position can take place anyway, in particular manually.

According to one embodiment, the sampling device 1 is for single use.

According to a particular embodiment, it is possible to disassemble the elements of the sampling device 1, in order to clean and sanitize it, as well as to replace the tip, namely the needle 2 secured to its support 20.

According to one embodiment, not shown, the sampling device 1 comprises elastic return means from the active position to the inactive position. Such elastic return means can be of any type, in particular a spring, preferably compression; said spring is then positioned, between at least two corresponding elements within the sampling device 1, to be compressed during the transition to the active position and ensure the automatic return to the inactive position.

Preferably, the return to the inactive position can take place by the positive pressure applied inside the tank 3 when it contains the fluid of a sample taken.

Once the sample has been taken, the sampling device 1 makes it possible to perform an in vitro test on the sample taken.

To do this, a measuring means 102 is positioned to allow contact with the sample taken and contained in the device 1 for taking samples. Such measuring means 102 can be of any type, in particular in the form of a paper dedicated to the absorption of said fluid from the sample, such as for example a test strip, in particular a test strip for blood glucose or blood glucose. of hemoglobin, intended to be analyzed by a dedicated device. According to a preferred embodiment, said body 4 comprises a window 44, while said tank 3 comprises a through orifice 34. In addition, said window 44 and said orifice 34 are located opposite each other in the active position or in the inactive position, preferably in the active position. In short, the window 44 and the orifice 34 are found aligned in an active or inactive position of the sampling device 1, providing a communication channel between the internal volume 30 of said reservoir 3 and the outside of said body 4.

Thus, it is possible to bring the measuring means 102 close to the window 44, so that it comes into contact with the fluid of the sample taken, contained in the reservoir 3 and accessible via the orifice 34.

The sampling device 1 allows a secure measurement, in that once the sampling has been carried out, the needle 2 remains in a safe position inside the body 4 without the risk of the user being pricked or the patient being pricked. . Such operation limits the risks of contact with the sample taken, in particular Accidents of Exposure to Viruses (AEV) or Accidents of Exposure to Blood (AES).

The invention also relates to the use of the sampling device 1, according to one and/or the other of the aforementioned embodiments, for taking a sample of bodily fluid from a septum 100, preferably a blood sample from a septum 100 present on an extracorporeal circuit 101.

According to one mode of implementation, the use makes it possible to measure and quantify in vitro a compound present in said sample taken, preferably in said blood sample taken.

According to one mode of implementation, the use makes it possible to measure the blood sugar level in said blood sample taken.

In the context of a sample for quantification of blood sugar, the use of the sampling device 1 complies with the standards in force relating to capillary blood sugar, authorizing the use of capillary blood sugar diagnostic devices.

According to another embodiment, the use makes it possible to measure the level of hemoglobin in said blood sample taken.

Thus, the sampling device 1 according to the invention improves patient care, by promoting a clean and sterile medical procedure, with easy and risk-free handling.

In addition, the amount of fluid, preferably blood, collected is minimal and perfectly suited to the uses envisaged.

Claims

Device (1) for taking a sample from a septum (100), comprising:

- a needle (2) provided hollow, in the form of a tube, fixedly mounted on a support (20),

- an internal reservoir (3) connected to said needle (2), said internal reservoir (3) comprising walls delimiting an interior volume (30) provided communicating with the needle

(2),

- a hollow body (4) receiving said support (20) and said tank

(3), said needle (2) being oriented towards a first end (40) of said body (4),

- Means (5) for gripping located at an opposite end of said body (4); characterized in that at least:

- said support (20) is placed inside said body (4), said needle (2) being entirely contained inside said body (4), and

- said body (4) comprising at its first end (40), an open housing (41), said housing (41) providing an interior space for receiving said septum (100), said needle (2) communicating with said interior space of said housing (41). Sampling device (1) according to claim 1, characterized in that said support (20) is mounted to move relative to said body (4), from an inactive position of said needle (2) retracted relative to said housing (41), towards a protruding active position inside the interior volume of said housing (41), and vice versa. Sampling device (1) according to claim 2, characterized in that said support (20) is slidably mounted inside said body (4), said support (20) being actuated by movement in support of said means (5) gripping devices provided to be movable with respect to said opposite end of said body (4), the movement of said gripping means (5) taking place simultaneously by applying pressure against said opposite end and pulling said means (5) to grip towards said opposite end, relative to one another.

4. Device (1) for sampling according to one of the preceding claims, characterized in that said reservoir (3) forms said opposite end of said device (1) for sampling.

5. Device (1) for sampling according to one of the preceding claims, characterized in that it comprises a member (7) mounted inside said reservoir (3), in the manner of a piston actuated by said gripping means (5).

6. Device (1) for sampling according to one of claims 2 to 5, characterized in that it comprises elastic return means from the active position to the inactive position.

7. Device (1) for sampling according to one of claims 2 to 6, characterized in that said body (4) comprises a window (44), while said reservoir (3) comprises an orifice (34) passing through, said window (44) and said orifice (34) located opposite each other in the active position or in the inactive position.

8. Use of the sampling device (1) according to one of the preceding claims, for taking a sample of bodily fluid from a septum (100).

9. Use according to claim 8, for taking a blood sample from a septum (100) present on a circuit (101) extracorporeal.

10. Use according to claim 9, for measuring and quantifying a compound present in said collected blood sample.

1 1. Use according to claim 10, for measuring the level of blood sugar or hemoglobin in said blood sample taken.