WO2023122731A3 - A live attenuated mumps virus-based sars-cov-2 vaccine - Google Patents
A live attenuated mumps virus-based sars-cov-2 vaccine Download PDFInfo
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- WO2023122731A3 WO2023122731A3 PCT/US2022/082244 US2022082244W WO2023122731A3 WO 2023122731 A3 WO2023122731 A3 WO 2023122731A3 US 2022082244 W US2022082244 W US 2022082244W WO 2023122731 A3 WO2023122731 A3 WO 2023122731A3
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- live attenuated
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18711—Rubulavirus, e.g. mumps virus, parainfluenza 2,4
- C12N2760/18721—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18711—Rubulavirus, e.g. mumps virus, parainfluenza 2,4
- C12N2760/18741—Use of virus, viral particle or viral elements as a vector
- C12N2760/18743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18711—Rubulavirus, e.g. mumps virus, parainfluenza 2,4
- C12N2760/18751—Methods of production or purification of viral material
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20071—Demonstrated in vivo effect
Abstract
Disclosed herein are live attenuated recombinant mumps virus (rMuV)-based SARS-CoV-2 vaccines and methods for vaccinating a subject for COVID-19 using the disclosed vaccines. Advantages of MuV-based SARS-CoV-2 vaccine include a great safety record, ideal for infants and children, overcomes the pre-existing MuV immunity, no integration to host DNA, high expression level, high efficacy, long term (life-long) immunity, excellent genetic stability, well-established GMP vaccine manufacture, a quadrivalent vaccine for SARS-CoV-2, MeV, MuV, and rubella virus, protection against SARS-CoV-2 variants, human clinical trial experience, and the MMR vaccine is lyophilized and stored at refrigerator temperatures both before and after it is reconstituted, greatly reducing its cost.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163292857P | 2021-12-22 | 2021-12-22 | |
US63/292,857 | 2021-12-22 |
Publications (2)
Publication Number | Publication Date |
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WO2023122731A2 WO2023122731A2 (en) | 2023-06-29 |
WO2023122731A3 true WO2023122731A3 (en) | 2023-08-31 |
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PCT/US2022/082244 WO2023122731A2 (en) | 2021-12-22 | 2022-12-22 | A live attenuated mumps virus-based sars-cov-2 vaccine |
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Citations (3)
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US20070258997A1 (en) * | 1999-08-02 | 2007-11-08 | Wyeth | Rescue of mumps virus from CDNA |
WO2021222228A1 (en) * | 2020-04-27 | 2021-11-04 | Ohio State Innovation Foundation | A live attenuated measles virus vectored vaccine for sars-cov-2 |
CN113773372A (en) * | 2021-08-15 | 2021-12-10 | 北京科兴中维生物技术有限公司 | Recombinant protein and preparation method and application thereof |
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2022
- 2022-12-22 WO PCT/US2022/082244 patent/WO2023122731A2/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US20070258997A1 (en) * | 1999-08-02 | 2007-11-08 | Wyeth | Rescue of mumps virus from CDNA |
WO2021222228A1 (en) * | 2020-04-27 | 2021-11-04 | Ohio State Innovation Foundation | A live attenuated measles virus vectored vaccine for sars-cov-2 |
CN113773372A (en) * | 2021-08-15 | 2021-12-10 | 北京科兴中维生物技术有限公司 | Recombinant protein and preparation method and application thereof |
Non-Patent Citations (11)
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ZHANG YUEXIU, MIJIA LU, K C MAHESH, EUNSOO KIM, MOHAMED M. SHAMSELDIN, CHENGJIN YE, PIYUSH DRAVID, MICHELLE CHAMBLEE, JUN-GYU PAR: "A highly efficacious live attenuated mumps virus–based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike ", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, 27 July 2022 (2022-07-27), pages 1 - 12, XP093021457, ISSN: 0027-8424 * |
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WO2023122731A2 (en) | 2023-06-29 |
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