WO2023114723A3 - Biomarkers for dendritic cells - Google Patents

Biomarkers for dendritic cells Download PDF

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Publication number
WO2023114723A3
WO2023114723A3 PCT/US2022/081373 US2022081373W WO2023114723A3 WO 2023114723 A3 WO2023114723 A3 WO 2023114723A3 US 2022081373 W US2022081373 W US 2022081373W WO 2023114723 A3 WO2023114723 A3 WO 2023114723A3
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WO
WIPO (PCT)
Prior art keywords
dendritic cells
biomarkers
methods
dendritic cell
dendritic
Prior art date
Application number
PCT/US2022/081373
Other languages
French (fr)
Other versions
WO2023114723A2 (en
Inventor
Lisa H. Butterfield
Juraj ADAMIK
Paul MUNSON
Original Assignee
Parker Institute For Cancer Immunotherapy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parker Institute For Cancer Immunotherapy filed Critical Parker Institute For Cancer Immunotherapy
Publication of WO2023114723A2 publication Critical patent/WO2023114723A2/en
Publication of WO2023114723A3 publication Critical patent/WO2023114723A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present disclosure generally relates to, inter alia, methods for characterizing dendritic cells as well as methods for identifying a dendritic cell as either an inflammatory or a tolerogenic dendritic cell.
PCT/US2022/081373 2021-12-13 2022-12-12 Biomarkers for dendritic cells WO2023114723A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163289104P 2021-12-13 2021-12-13
US63/289,104 2021-12-13

Publications (2)

Publication Number Publication Date
WO2023114723A2 WO2023114723A2 (en) 2023-06-22
WO2023114723A3 true WO2023114723A3 (en) 2023-08-17

Family

ID=86773528

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2022/081373 WO2023114723A2 (en) 2021-12-13 2022-12-12 Biomarkers for dendritic cells

Country Status (1)

Country Link
WO (1) WO2023114723A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170182076A1 (en) * 2011-02-15 2017-06-29 Ecole Polytechnique Federale De Lausanne (Epfl) Methods of treating mitochondrial dysfunction
US20190269739A1 (en) * 2016-11-03 2019-09-05 Exostem Biotec Ltd. Mesenchymal stem cells populations, their products, and use thereof
WO2020263192A1 (en) * 2019-06-26 2020-12-30 Agency For Science, Technology And Research Method of identifying pro-inflammatory dendritic cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170182076A1 (en) * 2011-02-15 2017-06-29 Ecole Polytechnique Federale De Lausanne (Epfl) Methods of treating mitochondrial dysfunction
US20190269739A1 (en) * 2016-11-03 2019-09-05 Exostem Biotec Ltd. Mesenchymal stem cells populations, their products, and use thereof
WO2020263192A1 (en) * 2019-06-26 2020-12-30 Agency For Science, Technology And Research Method of identifying pro-inflammatory dendritic cells

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ADAMIK JURAJ, MAURER DEENA, MUNSON PAUL, COMBES ALEXIS, PIERRE PHILIPPE, KRUMMEL MATTHEW, ARGÜELLO RAFAEL, BUTTERFIELD LISA: "299 Immuno-metabolic signatures of dendritic cells associate with T-cell responses in melanoma patients", REGULAR AND YOUNG INVESTIGATOR AWARD ABSTRACTS, BMJ PUBLISHING GROUP LTD, 1 November 2020 (2020-11-01), pages A183 - A183, XP093085451, DOI: 10.1136/jitc-2020-SITC2020.0299 *
ARGÜELLO RAFAEL J., COMBES ALEXIS J., CHAR REMY, GIGAN JULIEN-PAUL, BAAZIZ ANIA I., BOUSIQUOT EVENS, CAMOSSETO VOAHIRANA, SAMAD BU: "SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution", CELL METABOLISM, CELL PRESS, UNITED STATES, vol. 32, no. 6, 1 December 2020 (2020-12-01), United States , pages 1063 - 1075.e7, XP093085452, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2020.11.007 *
JANA ET AL.: "Complex I and II are required for normal mitochondrial Ca2+ homeostasis", MITOCHONDRIAN, vol. 49, 2019, pages 73 - 82, XP085927195, DOI: 10.1016/j.mito.2019.07.004 *
JI DONG, YIN JIAN-YUN, LI DAN-FENG, ZHU CHANG-TAI, YE JIAN-PING, PAN YUAN-QING: "Effects of inflammatory and anti-inflammatory environments on the macrophage mitochondrial function", SCIENTIFIC REPORTS, vol. 10, no. 1, XP093085455, DOI: 10.1038/s41598-020-77370-x *
SANDER JIL; SCHMIDT SUSANNE V.; CIROVIC BRANKO; MCGOVERN NAOMI; PAPANTONOPOULOU OLYMPIA; HARDT ANNA-LENA; ASCHENBRENNER ANNA C.; K: "Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2", IMMUNITY, CELL PRESS, AMSTERDAM, NL, vol. 47, no. 6, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 1051, XP085320548, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.11.024 *
TANNER LUKAS BAHATI, GOGLIA ALEXANDER G., WEI MONICA H., SEHGAL TALEN, PARSONS LANCE R., PARK JUNYOUNG O., WHITE EILEEN, TOETTCHER: "Four Key Steps Control Glycolytic Flux in Mammalian Cells", CELL SYSTEMS, CELL PRESS, US, vol. 7, no. 1, 1 July 2018 (2018-07-01), US , pages 49 - 62.e8, XP093085453, ISSN: 2405-4712, DOI: 10.1016/j.cels.2018.06.003 *

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Publication number Publication date
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