WO2023104114A3 - Rna formulations and lipids - Google Patents

Rna formulations and lipids Download PDF

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Publication number
WO2023104114A3
WO2023104114A3 PCT/CN2022/137326 CN2022137326W WO2023104114A3 WO 2023104114 A3 WO2023104114 A3 WO 2023104114A3 CN 2022137326 W CN2022137326 W CN 2022137326W WO 2023104114 A3 WO2023104114 A3 WO 2023104114A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipids
rna
rna formulations
therapeutic
vaccine
Prior art date
Application number
PCT/CN2022/137326
Other languages
French (fr)
Other versions
WO2023104114A2 (en
WO2023104114A8 (en
Inventor
Zihao Wang
Yuanqing LIU
Yanni Chen
Qizhi HU
Zhijun Guo
Hongyue WU
Original Assignee
Immorna (hangzhou) Biotechnology Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immorna (hangzhou) Biotechnology Co., Ltd. filed Critical Immorna (hangzhou) Biotechnology Co., Ltd.
Publication of WO2023104114A2 publication Critical patent/WO2023104114A2/en
Publication of WO2023104114A3 publication Critical patent/WO2023104114A3/en
Publication of WO2023104114A8 publication Critical patent/WO2023104114A8/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The disclosure relates to the method of lyophilizing RNA and mixing with a liquid LNP solution, e. g., to make an RNA vaccine or therapeutic. Included are methods for preparing and administering the vaccine or therapeutic.
PCT/CN2022/137326 2021-12-07 2022-12-07 Rna formulations and lipids WO2023104114A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2021136110 2021-12-07
CNPCT/CN2021/136110 2021-12-07
CN2022118152 2022-09-09
CNPCT/CN2022/118152 2022-09-09

Publications (3)

Publication Number Publication Date
WO2023104114A2 WO2023104114A2 (en) 2023-06-15
WO2023104114A3 true WO2023104114A3 (en) 2023-07-20
WO2023104114A8 WO2023104114A8 (en) 2024-03-28

Family

ID=84901237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/137326 WO2023104114A2 (en) 2021-12-07 2022-12-07 Rna formulations and lipids

Country Status (1)

Country Link
WO (1) WO2023104114A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012051211A2 (en) * 2010-10-11 2012-04-19 Novartis Ag Antigen delivery platforms
WO2016037053A1 (en) * 2014-09-05 2016-03-10 Novartis Ag Lipids and lipid compositions for the delivery of active agents
WO2018089846A1 (en) * 2016-11-10 2018-05-17 Translate Bio, Inc. Subcutaneous delivery of messenger rna
WO2020061457A1 (en) * 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
WO2020264138A1 (en) * 2019-06-27 2020-12-30 Emd Millipore Corporation Cell expansion with self-replicating rna vectors expressing immortalization proteins
CN112961065A (en) * 2021-02-05 2021-06-15 嘉晨西海(杭州)生物技术有限公司 Ionizable lipid molecule, preparation method thereof and application thereof in preparation of lipid nanoparticles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014152027A1 (en) 2013-03-15 2014-09-25 Moderna Therapeutics, Inc. Manufacturing methods for production of rna transcripts

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012051211A2 (en) * 2010-10-11 2012-04-19 Novartis Ag Antigen delivery platforms
WO2016037053A1 (en) * 2014-09-05 2016-03-10 Novartis Ag Lipids and lipid compositions for the delivery of active agents
WO2018089846A1 (en) * 2016-11-10 2018-05-17 Translate Bio, Inc. Subcutaneous delivery of messenger rna
WO2020061457A1 (en) * 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
WO2020264138A1 (en) * 2019-06-27 2020-12-30 Emd Millipore Corporation Cell expansion with self-replicating rna vectors expressing immortalization proteins
CN112961065A (en) * 2021-02-05 2021-06-15 嘉晨西海(杭州)生物技术有限公司 Ionizable lipid molecule, preparation method thereof and application thereof in preparation of lipid nanoparticles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANDREW J GEALL ET AL: "Nonviral delivery of self-amplifying RNA vaccines", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 109, no. 36, 4 September 2012 (2012-09-04), pages 14604 - 14609, XP002683929, ISSN: 0027-8424, [retrieved on 20120820], DOI: 10.1073/PNAS.1209367109 *
BLAKNEY ANNA K. ET AL: "Effect of complexing lipids on cellular uptake and expression of messenger RNA in human skin explants", JOURNAL OF CONTROLLED RELEASE, vol. 330, 1 February 2021 (2021-02-01), AMSTERDAM, NL, pages 1250 - 1261, XP055889259, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.11.033 *

Also Published As

Publication number Publication date
WO2023104114A2 (en) 2023-06-15
WO2023104114A8 (en) 2024-03-28

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