WO2023102969A1 - 可收集小动物排泄物的睡眠剥夺装置 - Google Patents

可收集小动物排泄物的睡眠剥夺装置 Download PDF

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Publication number
WO2023102969A1
WO2023102969A1 PCT/CN2021/137900 CN2021137900W WO2023102969A1 WO 2023102969 A1 WO2023102969 A1 WO 2023102969A1 CN 2021137900 W CN2021137900 W CN 2021137900W WO 2023102969 A1 WO2023102969 A1 WO 2023102969A1
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Prior art keywords
cage
rotating rod
excrement
sleep deprivation
axis rotating
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PCT/CN2021/137900
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English (en)
French (fr)
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李栩琳
周圆
王枫
王立平
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中国科学院深圳先进技术研究院
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Publication of WO2023102969A1 publication Critical patent/WO2023102969A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/03—Housing for domestic or laboratory animals
    • A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00—Housing animals; Equipment therefor
    • A01K1/01—Removal of dung or urine, e.g. from stables
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0083—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus especially for waking up

Definitions

  • the invention belongs to the technical field of animal experiment equipment, and in particular relates to a sleep deprivation device capable of collecting excrement of small animals.
  • Sufficient sleep is one of the important conditions to maintain the orderly operation of various physiological functions of the body. Short-term or long-term lack of sleep can cause physiological dysfunction of the body, including intestinal flora, metabolism, waste excretion and other functions. Analysis of (feces and urine) components can explore the impact of sleep deprivation on the above functions of the body.
  • the existing commonly used sleep deprivation instrument methods are mainly divided into the platform water environment method (such as the utility model with the Chinese patent publication number "CN213343862U”), the forced running method (such as the utility model with the Chinese patent publication number "CN201775854U”), Electric stimulation method and rotary rod deprivation method (such as the utility model whose Chinese patent publication number is "CN211482388U”).
  • the platform water environment method such as the utility model with the Chinese patent publication number "CN213343862U”
  • the forced running method such as the utility model with the Chinese patent publication number "CN201775854U”
  • Electric stimulation method and rotary rod deprivation method
  • rotary rod deprivation method such as the utility model whose Chinese patent publication number is "CN211482388U”
  • the electrical stimulation method may also cause changes in the physiological indicators of small animals due to strong stress.
  • the rotarod deprivation method is currently a method with a high degree of acceptance, a relatively mild method of sleep deprivation, and will not introduce variables such as excessive exercise.
  • the sleep deprivation device is usually located at the base, excreta cannot be separated and collected in time, and it is easy to cause pollution to the motor.
  • the current practice is to collect metabolic cages continuously for more than 6 hours after sleep deprivation; however, after sleep deprivation modeling animals will appear rebound sleep, resulting in little or no collection of excreta; while animals sleep Changes in the wakefulness state will affect the animal's metabolism and excretion function, so that reliable data cannot be obtained; in addition, due to the rhythmicity of physiological processes such as sodium salt metabolism, the staggering of sleep deprivation and excrement collection time may not be true due to its own rhythmicity. the result of.
  • the technical problem solved by the invention is: how to realize the unification of sleep deprivation and excrement collection of small experimental animals.
  • a sleep deprivation device capable of collecting small animal excrement comprising:
  • the cage includes a cage body and a grid cage bottom installed at the lower end of the cage body, the grid cage bottom is used to carry the experimental animals in the cage and filter out the excrement of the experimental animals;
  • the sleep deprivation assembly includes a driving mechanism and a rotating rod, the driving mechanism is installed above the cage, the rotating rod extends into the cage from top to bottom, and the driving mechanism is used to drive the rotating The rod is rotated to disturb the experimental animal in the cage;
  • the excrement collection assembly is arranged under the bottom of the grid cage, and is used to separate and collect solid excrement and liquid excrement in the excrement filtered out by the bottom of the grid cage.
  • the rotating rod includes a longitudinal axis rotating rod and a horizontal axis rotating rod
  • the longitudinal axis rotating rod is vertically arranged in the cage
  • the horizontal axis rotating rod is horizontally connected to the longitudinal axis rotating rod
  • the driving mechanism is used to drive the vertical axis rotating rod to rotate vertically, so as to drive the horizontal axis rotating rod to rotate horizontally.
  • the horizontal-axis rotating rod is detachably connected to the longitudinal-axis rotating rod, and the horizontal-axis rotating rod can move along the height direction of the longitudinal-axis rotating rod.
  • the sleep deprivation assembly further includes a screw, the side wall of the longitudinal-axis rotating rod has vertically distributed thread strips, the screw is fixed to the longitudinal-axis rotating rod, and the screw is connected to the longitudinal-axis rotating rod.
  • the threaded strips are threaded.
  • the cage also includes a cage cover, the cage cover is arranged on the upper end of the cage body;
  • the drive mechanism includes a motor and a coupling, the motor is installed on the cage cover, the The top end of the longitudinal axis rotating rod is fixedly connected with the output shaft of the motor through the coupling.
  • the driving mechanism further includes a shock-absorbing pad, the shock-absorbing pad is arranged on the cage cover, and the motor is installed on the shock-absorbing pad.
  • the excrement collection assembly includes a cone-shaped funnel, a filter screen and a collection bottle
  • the large mouth end of the cone-shaped funnel is detachably connected to the edge of the lower end of the cage, and the collection bottle is connected to the The small end of the cone-shaped funnel
  • the filter screen is arranged in the cone-shaped funnel
  • the filter screen is used to separate and collect the solid excrement in the excrement
  • the collection bottle is used to collect the solid excrement in the excrement liquid excrement.
  • the cage also includes a drinking fountain and a feeder, a first opening and a second opening are opened on the side wall of the cage, the drinking fountain is installed in the first opening, and the feeding apparatus is installed in the first opening. at the second opening.
  • the grid cage bottom is detachably mounted on the lower end of the cage body.
  • the invention discloses a sleep deprivation device capable of collecting excrement of small animals. Compared with the prior art, it has the following technical effects:
  • the sleep deprivation component By separating the sleep deprivation component and the excrement collection component up and down, the interference of the sleep deprivation component on the separation and collection of excrement can be avoided, the flexibility is high, the application scenarios are wide, and the sleep deprivation mode is relatively mild.
  • FIG. 1 is a schematic diagram of a sleep deprivation device capable of collecting excrement of small animals according to Embodiment 1 of the present invention.
  • the sleep deprivation device for small animals in the prior art usually installs the sleep deprivation equipment at the bottom, so that when sleep deprivation is performed, it cannot be timely Separate and collect excreta. For this reason, the application provides a sleep deprivation device that can collect excrement of small animals.
  • a drive mechanism is installed above the cage, and the rotating rod is inserted into the cage to disturb the experimental animals in the cage by using the rotating rod.
  • the excrement collection assembly is installed under the cage to collect the excrement collected by the experimental animals.
  • the sleep deprivation device capable of collecting excrement of small animals disclosed in Embodiment 1 includes a cage, a sleep deprivation assembly, and an excrement collection assembly.
  • the cage comprises a cage body 11 and a grid cage bottom 12 installed at the lower end of the cage body 11, and the grid cage bottom 11 is used to carry the experimental animals in the cage body 11 and filter out the excrement of the experimental animals.
  • the sleep deprivation assembly includes a driving mechanism and a rotating rod.
  • the driving mechanism is installed above the cage body 11, and the rotating rod extends into the cage body from top to bottom. Disturbance of experimental animals.
  • the grid cage bottom 12 is detachably installed on the lower end of the cage body 11, which is convenient for removing the grid cage bottom 12 for cleaning.
  • the rotating rod includes a vertical axis rotating rod 21 and a horizontal axis rotating rod 22, the vertical axis rotating rod 21 is vertically arranged in the cage body 11, the horizontal axis rotating rod 22 is horizontally connected to the longitudinal axis rotating rod 21, and the driving mechanism is used To drive the vertical axis rotating rod 21 to rotate vertically, to drive the horizontal axis rotating rod 22 to rotate horizontally, forcing the small animal to avoid the horizontal axis rotating rod 22, so as to realize sleep deprivation for the small animal.
  • the length of the vertical axis rotating rod 21 is 8 cm
  • the length of the horizontal axis rotating rod 22 is 12 cm.
  • the lengths of the vertical axis rotating rod 21 and the horizontal axis rotating rod 22 can be set according to actual needs, and are not limited here.
  • the sleep deprivation method of forcing animals to avoid the rotating rod in this embodiment is milder and can be applied to complete sleep deprivation needs.
  • the horizontal axis rotating rod 22 is detachably connected to the vertical axis rotating rod 21, and the horizontal axis rotating rod 22 can move along the height direction of the vertical axis rotating rod 21, so that the rotation height of the horizontal axis rotating rod 22 can be adjusted to Adapt to experimental animals of different sizes to achieve the effect of sufficient sleep deprivation.
  • the horizontal axis rotating rod 22 and the vertical axis rotating rod 21 can be removed for cleaning in a detachable manner, and the horizontal axis rotating rod 22 and the vertical axis rotating rod 21 of different lengths can also be replaced.
  • the sleep deprivation assembly further includes a screw part 23, the side wall of the longitudinal axis rotating rod 21 has threaded strips distributed vertically, the screw part 23 is fixed to the horizontal axis rotating rod 22, and the screw part 23 is threadedly connected with the threaded bars.
  • the up and down movement of the horizontal axis rotating rod 22 can be realized by turning the screw member 23 .
  • Screw part 23 adopts M6 screw part.
  • the cage also includes a cage cover 13, and the cage cover 13 covers the upper end of the cage body 11;
  • the driving mechanism includes a motor 24 and a shaft coupling 25, and the motor 24 is installed on the cage cover 13, and the top end of the longitudinal axis rotating rod 21 passes through
  • the shaft coupling 25 is fixedly connected to the output shaft of the motor 24, and by adjusting the speed of the motor 24, the speed of the horizontal axis rotating rod 22 is adjusted to meet the modeling requirements of complete sleep deprivation or segmental sleep deprivation.
  • the driving mechanism also includes a shock absorber 26, which is arranged on the cage cover 13, and the motor 24 is installed on the shock absorber 26 to realize the buffering of the motor 24 and ensure the stability of the motor 24 during rotation.
  • the excrement collection assembly includes a cone-shaped funnel 31, a filter screen 32 and a collection bottle 33.
  • the large mouth end of the cone-shaped funnel 31 is detachably connected to the edge of the lower end of the cage body 11, and the collection bottle 33 is connected to the bottom of the cone-shaped funnel 31.
  • a filter screen 32 is arranged in the cone-shaped funnel 31, the filter screen 32 is used to separate and collect solid excrement in the excrement, and the collection bottle 33 is used to collect liquid excrement in the excrement.
  • the large mouth end of the cone-shaped funnel 31 is fixed on the edge of the lower end of the cage body 11 by means of bayonet locking.
  • the disassembly and assembly of the sleep deprivation assembly and the excrement collection assembly of this embodiment does not fix the use space and use place, and is convenient for carrying, transporting, assembling and cleaning.
  • the cage also includes a drinker 14 and a feeder 15 , a first opening and a second opening are opened on the side wall of the cage body 11 , the drinker 14 is installed in the first opening, and the feeder 15 is installed in the second opening.
  • the sleep deprivation device that can collect small animal excrement provided by this embodiment has high flexibility, wide application scenarios, relatively mild sleep deprivation mode, convenient excrement collection, and can effectively unify sleep deprivation and excrement collection.

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  • General Health & Medical Sciences (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
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  • Engineering & Computer Science (AREA)
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Abstract

一种可收集小动物排泄物的睡眠剥夺装置。睡眠剥夺装置包括：笼子，包括笼体(11)和安装于笼体(11)下端的网格笼底(12)，网格笼底(12)用于承载笼体(11)内的实验动物并滤出实验动物的排泄物；睡眠剥夺组件，包括驱动机构和转动棒，驱动机构安装于笼体(11)的上方，转动棒从上至下伸入于笼体(11)内，驱动机构用于驱动转动棒进行转动，以实现对笼体(11)内的实验动物的扰动；排泄物收集组件，设置于网格笼底(12)的下方，用于分离并收集网格笼底(12)滤出的排泄物中的固体排泄物和液体排泄物。通过将睡眠剥夺组件和排泄物收集组件上下分离设置，可以避免睡眠剥夺组件对排泄物的分离和收集造成干扰，灵活度高，应用场景广，睡眠剥夺方式较为温和。

Description

可收集小动物排泄物的睡眠剥夺装置 技术领域
本发明属于动物实验器材技术领域，具体地讲，涉及一种可收集小动物排泄物的睡眠剥夺装置。
背景技术
充足的睡眠是维持机体各项生理功能有序运作的重要条件之一，短期或长期睡眠不足会引起机体生理功能紊乱，其中包括肠道菌群、代谢、废物排泄等功能，通过对机体排泄物(粪便及尿液)成分的分析可探究睡眠不足对机体上述功能的影响。
现有常用的睡眠剥夺仪使用方法主要分为平台水环境法(如中国专利公开号为“CN213343862U”的实用新型)、强迫跑动法(如中国专利公开号为“CN201775854U”的实用新型)、电刺激法及转棒剥夺法(如中国专利公开号为“CN211482388U”的实用新型)。水平台环境法由于其底部环境的限制，无法收集小动物的排泄物；强迫跑动法的原理是使小动物不间断运动达到睡眠剥夺的目的，而过量运动可能会导致小动物的生理指标发生改变，增加了睡眠剥夺之外影响排泄物的因素；电刺激法由于导致较强的应激，也存在引起小动物过生理指标发生改变的可能。转棒剥夺法是目前接收程度较高，睡眠剥夺手段较温和，也不会引入例如运动过量等变量的方法，但由于其睡眠剥夺装置通常位于底座，排泄物无法及时分离和收集，且易造成对电机的污染。目前做法是在睡眠剥夺后后连续6小时以上的代谢笼收集；然而，在进行睡眠剥夺造模后的动物会出现反弹式睡眠，导致排泄物收集量过少或甚至收集不到；同时动物睡眠觉醒状态的改变会影响动物代谢和排泄功能，以致未能获得可靠数据；另外，由于钠盐代谢等生理过程存在节律性，睡眠剥夺与排泄物收集时间错开可能由于本身的节律性得不到真实的结果。
发明内容
(一)本发明所要解决的技术问题
本发明解决的技术问题是：如何实现对实验小动物的睡眠剥夺和排泄物收集的统一。
(二)本发明所采用的技术方案
一种可收集小动物排泄物的睡眠剥夺装置，所述睡眠剥夺装置包括：
笼子，包括笼体和安装于所述笼体下端的网格笼底，所述网格笼底用于承载所述笼体内的实验动物并滤出所述实验动物的排泄物；
睡眠剥夺组件，包括驱动机构和转动棒，所述驱动机构安装于所述笼体的上方，所述转动棒从上至下伸入于所述笼体内，所述驱动机构用于驱动所述转动棒进行转动，以实现对所述笼体内的实验动物的扰动；
排泄物收集组件，设置于所述网格笼底的下方，用于分离并收集所述网格笼底滤出的排泄物中的固体排泄物和液体排泄物。
可选择地，所述转动棒包括纵轴转棒和横轴转棒，所述纵轴转棒竖直设置于所述笼体内，所述横轴转棒水平连接于所述纵轴转棒上，所述驱动机构用于驱动所述纵轴转棒进行竖直转动，以带动所述横轴转棒进行水平转动。
可选择地，所述横轴转棒与所述纵轴转棒可拆卸连接，且所述横轴转棒可沿着所述纵轴转棒的高度方向移动。
可选择地，所述睡眠剥夺组件还包括螺丝件，所述纵轴转棒的侧壁具有竖直分布的螺纹条，所述螺丝件与所述纵轴转棒固定，且所述螺丝件与所述螺纹条螺纹连接。
可选择地，所述笼子还包括笼盖，所述笼盖盖设于所述笼体的上端；所述驱动机构包括电机和联轴器，所述电机安装于所述笼盖上，所述纵轴转棒的顶端通过所述联轴器与所述电机的输出轴固定连接。
可选择地，所述驱动机构还包括减震垫，所述减震垫设置于所述笼盖上，所述电机安装于所述减震垫上。
可选择地，所述排泄物收集组件包括锥体型漏斗、过滤网和收集瓶，所述锥体型漏斗的大口端可拆卸地连接于所述笼体下端的边缘，所述收集瓶连接于所述锥体型漏斗的小口端，所述过滤网设置于所述锥体型漏斗中，所述过滤网用于分离并收集所述排泄物中的固体排泄物，所述收集瓶用于收集排泄物中的 液体排泄物。
可选择地，所述笼子还包括饮水器和喂食器，所述笼体的侧壁上开设有第一开口和第二开口，所述饮水器安装于所述第一开口，所述喂食器安装于所述第二开口。
可选择地，所述网格笼底可拆卸地安装于所述笼体的下端。
(三)有益效果
本发明公开了一种可收集小动物排泄物的睡眠剥夺装置，相对于现有技术，具有如下技术效果：
通过将睡眠剥夺组件和排泄物收集组件上下分离设置，可以避免睡眠剥夺组件对排泄物的分离和收集造成干扰，灵活度高，应用场景广，睡眠剥夺方式较为温和。
附图说明
图1为本发明的实施例一的可收集小动物排泄物的睡眠剥夺装置的示意图。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本发明进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
在详细描述本申请的各个实施例之前，首先简单描述本申请的技术构思：现有技术中的小动物睡眠剥夺装置，通常将睡眠剥夺设备安装在底部，这样导致在进行睡眠剥夺时，无法及时分离和收集排泄物。为此，本申请提供了一种可收集小动物排泄物的睡眠剥夺装置，在笼体的上方安装驱动机构，将转动棒伸入于笼体内，利用转动棒扰动笼体内的实验动物，并将排泄物收集组件安装在笼体的下方，收集实验动物收集的排泄物。通过将睡眠剥夺组件和排泄物收集组件上下分离设置，可以避免睡眠剥夺组件对排泄物的分离和收集造成干扰。
具体地，如图1所示，本实施例一公开的可收集小动物排泄物的睡眠剥夺装置包括笼子、睡眠剥夺组件、排泄物收集组件。其中笼子包括笼体11和安装于笼体11下端的网格笼底12，网格笼底11用于承载笼体11内的实验动物并滤 出实验动物的排泄物。睡眠剥夺组件包括驱动机构和转动棒，驱动机构安装于笼体11的上方，转动棒从上至下伸入于笼体内，驱动机构用于驱动转动棒进行转动，以实现对笼体11内的实验动物的扰动。其中，网格笼底12可拆卸地安装于笼体11的下端，便于拆下网格笼底12进行清洗。
进一步地，转动棒包括纵轴转棒21和横轴转棒22，纵轴转棒21竖直设置于笼体11内，横轴转棒22水平连接于纵轴转棒21上，驱动机构用于驱动纵轴转棒21进行竖直转动，以带动横轴转棒22进行水平转动，迫使小动物躲避横轴转棒22，实现对小动物进行睡眠剥夺。示例性地，纵轴转棒21长度为8cm，横轴转棒22长度为12cm。其中，纵轴转棒21和横轴转棒22的长度可根据实际需求进行设置，在此不进行限定。相对于现有技术中，通过旋转台和挡板强迫动物无法入睡的睡眠剥夺方式，本实施例通过强迫动物躲避转棒的睡眠剥夺方式更加温和，且能适用于完全睡眠剥夺需求。
进一步地，横轴转棒22与纵轴转棒21可拆卸连接，且横轴转棒22可沿着纵轴转棒21的高度方向移动，这样可以调整横轴转棒22的转动高度，以适应不同体型的实验动物，达到充分睡眠剥夺的效果。同时，采用可拆卸的方式，可拆下横轴转棒22与纵轴转棒21进行清洗，也可更换不同长度的横轴转棒22与纵轴转棒21。
示例性地，睡眠剥夺组件还包括螺丝件23，纵轴转棒21的侧壁具有竖直分布的螺纹条，螺丝件23与横轴转棒22固定，且螺丝件23与螺纹条螺纹连接。通过拧动螺丝件23可实现横轴转棒22的上下移动。螺丝件23采用M6螺丝件。
进一步地，笼子还包括笼盖13，笼盖13盖设于笼体11的上端；驱动机构包括电机24和联轴器25，电机24安装于笼盖13上，纵轴转棒21的顶端通过联轴器25与电机24的输出轴固定连接，通过调节电机24的转速，对横轴转棒22进行转速调节，适应完全睡眠剥夺或片段式睡眠剥夺的造模需求。
驱动机构还包括减震垫26，减震垫26设置于笼盖13上，电机24安装于减震垫26上，实现对电机24的缓冲，保证电机24转动过程中的稳定性。
进一步地，排泄物收集组件包括锥体型漏斗31、过滤网32和收集瓶33，锥体型漏斗31的大口端可拆卸地连接于笼体11下端的边缘，收集瓶33连接于锥体型漏斗31的小口端，过滤网32设置于锥体型漏斗31中，过滤网32用于分离并收集排泄物中的固体排泄物，收集瓶33用于收集排泄物中的液体排泄物。
示例性地，锥体型漏斗31的大口端通过卡口卡接的方式固定在笼体11下端的边缘。本实施例的睡眠剥夺组件和排泄物收集组件的拆卸组装，因此不固定使用空间和使用场所，便于携带、运输、组装和清洗。
进一步地，笼子还包括饮水器14和喂食器15，笼体11的侧壁上开设有第一开口和第二开口，饮水器14安装于第一开口，喂食器15安装于第二开口。将实验动物的进食进水与代谢收集笼体分开，避免饮用水和食物残渣对排泄物的污染。
本实施例提供的可收集小动物排泄物的睡眠剥夺装置，其灵活度高，应用场景广，睡眠剥夺方式较为温和，排泄物收集方便，能达到睡眠剥夺与排泄物收集的有效统一。
上面对本发明的具体实施方式进行了详细描述，虽然已表示和描述了一些实施例，但本领域技术人员应该理解，在不脱离由权利要求及其等同物限定其范围的本发明的原理和精神的情况下，可以对这些实施例进行修改和完善，这些修改和完善也应在本发明的保护范围内。

Claims (9)

  1. 一种可收集小动物排泄物的睡眠剥夺装置，其中，所述睡眠剥夺装置包括：
    笼子，包括笼体和安装于所述笼体下端的网格笼底，所述网格笼底用于承载所述笼体内的实验动物并滤出所述实验动物的排泄物；
    睡眠剥夺组件，包括驱动机构和转动棒，所述驱动机构安装于所述笼体的上方，所述转动棒从上至下伸入于所述笼体内，所述驱动机构用于驱动所述转动棒进行转动，以实现对所述笼体内的实验动物的扰动；
    排泄物收集组件，设置于所述网格笼底的下方，用于分离并收集所述网格笼底滤出的排泄物中的固体排泄物和液体排泄物。
  2. 根据权利要求1所述的睡眠剥夺装置，其中，所述转动棒包括纵轴转棒和横轴转棒，所述纵轴转棒竖直设置于所述笼体内，所述横轴转棒水平连接于所述纵轴转棒上，所述驱动机构用于驱动所述纵轴转棒进行竖直转动，以带动所述横轴转棒进行水平转动。
  3. 根据权利要求2所述的睡眠剥夺装置，其中，所述横轴转棒与所述纵轴转棒可拆卸连接，且所述横轴转棒可沿着所述纵轴转棒的高度方向移动。
  4. 根据权利要求3所述的睡眠剥夺装置，其中，所述睡眠剥夺组件还包括螺丝件，所述纵轴转棒的侧壁具有竖直分布的螺纹条，所述螺丝件与所述纵轴转棒固定，且所述螺丝件与所述螺纹条螺纹连接。
  5. 根据权利要求2所述的睡眠剥夺装置，其中，所述笼子还包括笼盖，所述笼盖盖设于所述笼体的上端；所述驱动机构包括电机和联轴器，所述电机安装于所述笼盖上，所述纵轴转棒的顶端通过所述联轴器与所述电机的输出轴固定连接。
  6. 根据权利要求5所述的睡眠剥夺装置，其中，所述驱动机构还包括减震垫，所述减震垫设置于所述笼盖上，所述电机安装于所述减震垫上。
  7. 根据权利要求1所述的睡眠剥夺装置，其中，所述排泄物收集组件包括锥体型漏斗、过滤网和收集瓶，所述锥体型漏斗的大口端可拆卸地连接于所述笼体下端的边缘，所述收集瓶连接于所述锥体型漏斗的小口端，所述过滤网设置于所述锥体型漏斗中，所述过滤网用于分离并收集所述排泄物中的固体排泄物，所述收集瓶用于收集排泄物中的液体排泄物。
  8. 根据权利要求1所述的睡眠剥夺装置，其中，所述笼子还包括饮水器和喂食器，所述笼体的侧壁上开设有第一开口和第二开口，所述饮水器安装于所述第一开口，所述喂食器安装于所述第二开口。
  9. 根据权利要求1所述的睡眠剥夺装置，其中，所述网格笼底可拆卸地安装于所述笼体的下端。
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