WO2023102797A1 - 一种电极保护装置 - Google Patents
一种电极保护装置 Download PDFInfo
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- WO2023102797A1 WO2023102797A1 PCT/CN2021/136630 CN2021136630W WO2023102797A1 WO 2023102797 A1 WO2023102797 A1 WO 2023102797A1 CN 2021136630 W CN2021136630 W CN 2021136630W WO 2023102797 A1 WO2023102797 A1 WO 2023102797A1
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- protection device
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- main body
- cover plate
- protrusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
Definitions
- the invention relates to the field of body electrophysiological recording, in particular to an electrode protection device.
- microwire electrodes or silicon-based electrodes are usually surgically implanted into the target brain area of experimental animals, and then a predetermined experimental paradigm is performed to simultaneously record EEG signals and behavioral videos.
- a protective agent paraffin and liquid paraffin mixed at a ratio of 1:1 or medical grade Vaseline
- the integrated device in the prior art usually needs to install recording electrodes inside the protection device, so a large number of supporting structures need to be installed to carry the weight of the electrodes. Since the electrode needs a stable structure, the connection between the electrode and the protective device is rigid, but the skull of the mouse is uneven, and the bottom of the protective device needs to be bonded to the head of the mouse, so the shaking of the protective cover will cause the microwire electrode to Offsets, or movements, occur in the mouse brain, affecting experimental data. Moreover, the bottom of the current protective cover is mostly a circular sealing device, which seriously affects the field of vision when the electrode under the microscope enters the brain area, and is very unfavorable for observing the entry posture of the microwire electrode.
- the present invention provides an electrode protection device, the specific technical solution is as follows:
- An electrode protection device comprising:
- the main body, the first cover plate and the second cover plate, the main body has a cavity for installing the recording electrode, the bottom of the main body has a fence-type fixing part, and the fence-type fixing part is used to fix the part to be detected;
- the main body is provided with a first connector
- the first cover is provided with an insertion port and a second connector
- the insertion port is used to insert the headstage interface
- the second cover is provided with a third connection pieces
- the second connector is plug-connected with the first connector for fixing the first cover on the top of the main body
- the third connector is plug-connected with the first connector , for fixing the second cover on the top of the main body.
- the cross-sectional shape of the fence-type fixing member includes a circle.
- the fence-type fixing member includes at least two fixing feet, each of which is arranged at intervals.
- the first connecting part includes a first groove and a second groove
- the second connecting part includes a first protrusion
- the third connecting part includes a second protrusion
- the first protrusion is plugged into the first groove for fixing the first cover on the top of the main body
- the second protrusion is plugged into the second groove , for fixing the second cover on the top of the main body.
- the first protrusion comprises a hollow structure
- the second protrusion includes a hollow structure.
- both the first groove and the second groove are semi-cylindrical grooves
- the first protrusion includes a semi-cylindrical protrusion that cooperates with the first groove
- the second protrusion includes a semi-cylindrical protrusion that cooperates with the second groove
- the cross-sectional shape of the first cover plate includes a semicircle
- the cross-sectional shape of the second cover plate includes a semicircle
- the cross-sectional shape of the cavity includes a circle
- the first cover plate and the second cover plate are in contact with each other and form a circle conforming to the cross-sectional shape of the cavity.
- the shape of the insertion opening includes a rectangle.
- the shape of the insertion opening includes a circle, an ellipse, a triangle or a rhombus.
- the part to be detected includes the skull of a rodent.
- the present invention has the following beneficial effects:
- the electrode protection device provided by the invention can solve the problems that the electrode is bitten by experimental animals and is polluted by dust and other problems that affect electrophysiological signals during the experiment, can reduce the weight of the electrode protection device and improve the convenience of the electrode protection device It can further reduce the overall weight of the recording device, and can also increase the observation field of view when the electrodes are implanted. Stably fixed on the head of the mouse can prevent the electrode protection device from shaking and cause the electrode to shift or move in the brain of the mouse, which is conducive to improving the accuracy of the experimental data.
- Fig. 1 is the structural representation of electrode protection device in the embodiment
- Fig. 2 is a structural schematic view of the electrode protection device in the embodiment without the first cover plate and the second cover plate;
- Fig. 3 is the structural representation of the first cover plate in the embodiment
- Fig. 4 is a schematic structural view of the second cover plate in the embodiment.
- this embodiment provides an electrode protection device, including: a main body 1, a first cover plate 2 and a second cover plate 3, the main body 1 has a cavity 4 for installing recording electrodes , the bottom of the main body 1 has a fence-type fixing part 5, and the fence-type fixing part 5 is used to fix the part to be detected.
- the main body 1 is provided with a first connecting piece 6, the first connecting piece 6 is preferably arranged on the top of the main body 1, specifically preferably on the top of the cavity 4, and the first cover 2 is provided with an insertion port 7 and a second connecting piece 8, the insertion port 7 is used to insert the headstage interface, the second cover plate 3 is provided with a third connecting piece 9, the second connecting piece 8 is plugged and connected with the first connecting piece 6, and is used to fix the first cover plate 2 on the On the top of the main body 1 , the third connecting member 9 is plugged and connected with the first connecting member 6 for fixing the second cover plate 3 on the top of the main body 1 .
- the recording electrode is preferably a microwire electrode or a silicon-based electrode;
- the insertion port 7 is preferably a rectangular opening; specifically, the rectangular opening on the top of the main body 1 (that is, the rectangular opening on the first cover plate 2) is the headstage interface of Plexon Insertion port 7.
- Plexon is a multi-channel electrophysiological recorder, a multi-channel electrophysiological recorder is a scientific instrument used in the fields of biology and basic medicine; headstage is a front-end amplifier; Connector is a connector.
- the first cover plate 2 and the second cover plate 3 on the top of the main body 1 are spliced structures, which are different from other integral screw-in or integral plug-in types. On the premise of reducing the overall weight, it also greatly improves the stability.
- the headstage interface is bound by the top insertion port 7 of the main body 1 (that is, the insertion port 7 on the first cover plate 2), which is more synchronized with the behavior of the experimental mice, which can reduce the generation of motion noise and further improve the accuracy of the experimental data. quality.
- the present invention is used in mouse EEG recording surgery, adopts a separate protection device, can greatly reduce the weight of the electrode protection device, and can also reduce the difficulty of processing and assembly. At the same time, the damage to the electrode by the postoperative animal is largely avoided, and before the EEG data is collected, only a small amount of tape on the first cover 2 and the second cover 3 needs to be torn off, replacing the traditional tape protection. , to avoid the electrode falling off caused by a large torque when tearing off the tape.
- this embodiment can solve the problems that the electrodes are bitten by experimental animals and polluted by dust, etc., which affect the electrophysiological signals during the experiment, can reduce the weight of the electrode protection device and improve the convenience of the electrode protection device, and further reduce the
- the overall weight of the recording device can also increase the observation field of view when the electrodes are implanted, which is conducive to observing the entry posture of the electrodes, and is also conducive to fixing the electrode protection device and the head of the mouse, so that the electrode protection device can be more stably fixed on the mouse head.
- the head of the mouse can prevent the electrodes from shifting or moving in the brain of the mouse due to shaking of the electrode protection device, which is beneficial to improve the accuracy of the experimental data.
- the cross-sectional shape of the fence-type fixing member 5 includes a circle.
- the setting of the barrier-type fixing member 5 can greatly improve the stability of the main body 1, and can still have a better observation field during implantation while protecting the electrodes from external influences, and when fixed, Due to the fence-like structural design, dental cement can be poured and fixed at both ends of the bottom.
- the fence-type fixing member 5 includes at least two fixing feet, each of which is arranged at intervals.
- the fence-type fixing member 5 preferably includes 3 fixing feet, each fixing foot is arranged at intervals, and the distance between each fixing foot is preferably the same; it should be noted that the fence-type fixing member 5 includes 3 One fixing foot is only a preference of this embodiment, and in other embodiments, the fence-type fixing member 5 may include 2, 4 or 5 fixing feet.
- the first connector 6 includes a first groove 10 and a second groove 11
- the second connector 8 includes a first protrusion 12
- the third connector 9 includes a second protrusion 13
- the second connector 8 includes a first protrusion 12.
- a protrusion 12 fits with the first groove 10 for fixing the first cover 2 on the top of the main body 1
- a second protrusion 13 fits with the second groove 11 for making the second cover
- the plate 3 is fixed on top of the main body 1 .
- the first groove 10 and the second groove 11 are preferably arranged on the top of the main body 1, the first groove 10 is used as the insertion end of the first cover plate 2 for fixing the first cover plate 2, and the second groove
- the groove 11 is used as an insertion end of the second cover plate 3 for fixing the second cover plate 3 .
- the first protrusion 12 is used to insert into the first groove 10, so that the first cover plate 2 is fixed on the top of the main body 1, and the second protrusion 13 is used to be inserted into the second groove 11, so that the second cover plate 3 is fixed on the main body 1 top.
- the first protrusion 12 includes a hollow structure
- the second protrusion 13 includes a hollow structure
- the first protrusion 12 is a fixing device for the first cover plate 2 and the main body 1
- the second protrusion 13 is a fixing device for the second cover plate 3 and the main body 1.
- the first protrusion 12 and the second protrusion 13 All adopt a hollow design to reduce the overall weight of the electrode protection device.
- first groove 10 and the second groove 11 are both semi-cylindrical grooves
- first protrusion 12 includes a semi-cylindrical protrusion that cooperates with the first groove 10
- second protrusion 13 It includes a semi-cylindrical protrusion cooperating with the second groove 11 .
- the cross-sectional shape of the first cover plate 2 includes a semicircle
- the cross-sectional shape of the second cover plate 3 includes a semicircle
- the cross-sectional shape of the cavity 4 includes a circle
- the first cover plate 2 and The second cover plates 3 are in contact with each other and form a circle conforming to the cross-sectional shape of the cavity 4 .
- the shape of the insertion opening 7 includes a rectangle.
- the shape of the insertion opening 7 including a rectangle is only a preference in this embodiment, and in other embodiments, the shape of the insertion opening 7 may include a circle, an ellipse, a triangle or a rhombus.
- the part to be detected includes the skull of a rodent.
- all parts of the device are manufactured using 3D printing technology.
- the fence-like fixture 5 at the bottom of the main body 1 is fixed to the skull of the experimental mouse, and the first protrusion 12 on the first cover plate 2 is inserted into the first concave hole at the top of the main body 1 .
- the first cover plate 2 is fixed on the top of the main body 1, and the second protrusion 13 on the second cover plate 3 is inserted into the second groove 11 on the top of the main body 1, so that the second cover plate 3 is fixed on top of the main body 1 to complete the assembly.
- the first protrusion 12 on the first cover plate 2 is in clearance fit with the first groove 10 on the top of the main body 1, and the second protrusion 13 on the second cover plate 3 is in contact with the second groove 11 on the top of the main body 1 It is a gap fit, so it needs to be glued with adhesive plaster after the implantation operation is completed, and there is no need to use more adhesive tape for adhesion, which can avoid the phenomenon of large torque when removing the adhesive tape and avoid loosening.
- the insertion port 7 of the headstage also needs to be sealed with tape to prevent dust from falling in, and the tape is removed when it needs to be inserted into the headstage interface.
- the present invention can largely avoid postoperative animal damage to the electrode, and before collecting EEG data, only a small amount of adhesive tape on the first cover 2 and the second cover 3 needs to be torn off, replacing the traditional adhesive tape Protection, avoiding the electrode falling off caused by large torque when tearing off the tape.
- the main body 1 can also be integrated with a shielding device, so as to form a more comprehensive shielding field to offset the influence of noise on the EEG signal.
- the electrode protection device provided by this embodiment can solve the problems that the electrode is bitten by experimental animals and is polluted by dust and other problems that affect the electrophysiological signal during the experiment, and can reduce the damage of the electrode protection device.
- Weight and improve the convenience of the electrode protection device further reduce the overall weight of the recording device, and increase the observation field of view when the electrode is implanted, which is conducive to observing the entry posture of the electrode, and it is also beneficial to connect the electrode protection device and the head of the mouse. Fixed, so that the electrode protection device can be more stably fixed on the head of the mouse, which can prevent the electrodes from shifting or moving in the brain of the mouse caused by the shaking of the electrode protection device, which is conducive to improving the accuracy of the experimental data.
- modules in the devices in the implementation scenario can be distributed among the devices in the implementation scenario according to the description of the implementation scenario, or can be located in one or more devices different from the implementation scenario according to corresponding changes.
- the modules of the above implementation scenarios can be combined into one module, or can be further split into multiple sub-modules.
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Abstract
本发明提供一种电极保护装置，包括主体、第一盖板和第二盖板，主体内具有腔体，主体底部具有栅栏式固定件，主体上设置有第一连接件，第一盖板上设置有插入口和第二连接件，第二盖板上设置有第三连接件；第二连接件与第一连接件插接连接，第三连接件与第一连接件插接连接。与现有技术相比，本发明能解决在实验过程中电极被实验动物撕咬，以及受到灰尘污染等问题，能减轻电极保护装置的重量以及提高保护装置的便捷性，还能增加植入电极时的观察视野，有利于观察电极的进入姿态，有利于保护装置和小鼠头部的固定，使保护装置能够更稳定地固定在小鼠的头部，能避免保护装置晃动导致电极在小鼠脑中发生偏移或者移动，有利于提高实验数据的准确性。
Description
本发明涉及体电生理记录领域，具体是涉及一种电极保护装置。
在体多通道电生理记录技术中，通常需要将微丝电极或者硅基电极通过手术植入进入实验动物的目标脑区，再进行预定的实验范式，同时记录脑电信号和行为学视频。将传统的可步进微丝电极植入动物脑袋中以后，通常需要使用保护剂(石蜡与液体石蜡按1:1的比例混合或者医用级凡士林)将电极洞封起来，以免牙科水泥流入，这种方式十分麻烦，且难以得出准确地实验数据。
现有技术中存在将电极与保护装置做成一体化的产品，但这类产品存在缺陷，例如：
现有技术中的一体化装置通常需要在保护装置内部安装记录电极，故需要安装大量的支撑结构，以承载电极重量。由于电极需要稳定的结构，故电极与保护装置之间为刚性连接，但小鼠头骨凹凸不平，保护装置的底部需要与小鼠头部进行粘合，故保护套的晃动将会导致微丝电极在小鼠脑中发生偏移或者移动，对实验数据产生影响。且当前保护套的底部多为圆形封闭装置，严重影响镜下电极进入脑区时的视野，非常不利于观察微丝电极的进入姿态。
发明内容
为了克服现有技术的不足，本发明提供了一种电极保护装置，具体技术方案如下所示：
一种电极保护装置，包括：
主体、第一盖板和第二盖板，所述主体内具有腔体，用于安装记录电极，所述主体底部具有栅栏式固定件，所述栅栏式固定件用于固定于待检测部；
所述主体上设置有第一连接件，所述第一盖板上设置有插入口和第二连接件，所述插入口用于插入headstage接口，所述第二盖板上设置有第三连接件；
所述第二连接件与所述第一连接件插接连接、用于使所述第一盖板固定在所述主体的顶部，所述第三连接件与所述第一连接件插接连接、用于使所述第二盖板固定在 所述主体的顶部。
在一个具体的实施例中，所述栅栏式固定件的横截面形状包括圆形。
在一个具体的实施例中，所述栅栏式固定件包括至少2个固定脚，每个所述固定脚间隔设置。
在一个具体的实施例中，所述第一连接件包括第一凹槽和第二凹槽，所述第二连接件包括第一凸起，所述第三连接件包括第二凸起；
所述第一凸起与所述第一凹槽插接配合，用于使所述第一盖板固定在所述主体的顶部，所述第二凸起与所述第二凹槽插接配合，用于使所述第二盖板固定在所述主体的顶部。
在一个具体的实施例中，所述第一凸起包括中空的结构；
所述第二凸起包括中空的结构。
在一个具体的实施例中，所述第一凹槽和所述第二凹槽均为半圆柱形槽体；
所述第一凸起包括与所述第一凹槽互相配合的半圆柱形凸起，所述第二凸起包括与所述第二凹槽互相配合的半圆柱形凸起。
在一个具体的实施例中，所述第一盖板的横截面形状包括半圆形，所述第二盖板的横截面形状包括半圆形，所述腔体的横截面形状包括圆形；
所述第一盖板和所述第二盖板互相接触、构成与所述腔体的横截面形状吻合的圆形。
在一个具体的实施例中，所述插入口的形状包括矩形。
在一个具体的实施例中，所述插入口的形状包括圆形、椭圆形、三角形或菱形。
在一个具体的实施例中，所述待检测部包括鼠类的头骨。
相对于现有技术，本发明具有以下有益效果：
本发明提供的一种电极保护装置，能够解决在实验过程中电极被实验动物撕咬，以及受到灰尘污染等一些影响电生理信号的问题，能够减轻电极保护装置的重量以及提高电极保护装置的便捷性，进一步减轻记录装置整体的重量，还能增加植入电极时的观察视野，有利于观察电极的进入姿态，还有利于将电极保护装置和小鼠头部进行固定，使电极保护装置能够更稳定地固定在小鼠的头部，能够避免电极保护装置晃动导致电极在小鼠脑中发生偏移或者移动，有利于提高实验数据的准确性。
为使本发明的上述目的、特征和优点能更明显易懂，下文特举较佳实施例，并配合所附附图，作详细说明如下。
为了更清楚地说明本发明实施例的技术方案，下面将对实施例中所需要使用的附图作简单地介绍，应当理解，以下附图仅示出了本发明的某些实施例，因此不应被看作是对范围的限定，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他相关的附图。
图1是实施例中电极保护装置的结构示意图；
图2是实施例中电极保护装置除去第一盖板和第二盖板的结构示意图；
图3是实施例中第一盖板的结构示意图；
图4是实施例中第二盖板的结构示意图。
主要元件符号说明：
1-主体；2-第一盖板；3-第二盖板；4-腔体；5-栅栏式固定件；6-第一连接件；7-插入口；8-第二连接件；9-第三连接件；10-第一凹槽；11-第二凹槽；12-第一凸起；13-第二凸起。
实施例
如图1-图4所示，本实施例提供了一种电极保护装置，包括：主体1、第一盖板2和第二盖板3，主体1内具有腔体4，用于安装记录电极，主体1底部具有栅栏式固定件5，栅栏式固定件5用于固定于待检测部。主体1上设置有第一连接件6，第一连接件6优选设置在主体1的顶部，具体优选设置在腔体4的顶部，第一盖板2上设置有插入口7和第二连接件8，插入口7用于插入headstage接口，第二盖板3上设置有第三连接件9，第二连接件8与第一连接件6插接连接、用于使第一盖板2固定在主体1的顶部，第三连接件9与第一连接件6插接连接、用于使第二盖板3固定在主体1的顶部。
优选地，记录电极优选为微丝电极或者硅基电极；插入口7优选为矩形开口；具体地，主体1顶部的矩形开口(即第一盖板2上的矩形开口)为Plexon的headstage接口的插入口7，在植入手术需要注意将Connector插入口对准该矩形开口，方便heandstage接口插入。Plexon为多通道电生理记录仪，多通道电生理记录仪是一种用于生物学、基础医学领域的科学仪器；headstage为前端放大器；Connector为连接器。
具体地，主体1顶部的第一盖板2和第二盖板3均为拼接式结构，不同于其他的整体旋入式或整体插入式，在减轻整体重量的前提下，还大大提升了稳定性，且headstage接口由于有主体1顶部插入口7(即第一盖板2上的插入口7)的束缚，与实验鼠的行为更加同步，能够减少运动噪音的产生，进一步提高了实验数据的质量。
具体地，本发明用于小鼠脑电记录手术，采用分离式保护装置，能够大大减轻电极保护装置的重量，还能减轻加工装配的难度。同时极大程度上避免了术后动物对电极的破坏，且在脑电数据采集之前，仅需将第一盖板2和第二盖板3的少量胶带撕开即可，取代了传统胶带保护，避免了在撕开胶带时产生大扭矩导致的电极脱落。
优选地，本实施例能够解决在实验过程中电极被实验动物撕咬，以及受到灰尘污染等一些影响电生理信号的问题，能够减轻电极保护装置的重量以及提高电极保护装置的便捷性，进一步减轻记录装置整体的重量，还能增加植入电极时的观察视野，有利于观察电极的进入姿态，还有利于将电极保护装置和小鼠头部进行固定，使电极保护装置能够更稳定地固定在小鼠的头部，能够避免电极保护装置晃动导致电极在小鼠脑中发生偏移或者移动，有利于提高实验数据的准确性。
本实施例中，栅栏式固定件5的横截面形状包括圆形。
具体地，栅栏式固定件5的设置能够大大提升主体1的稳定性，还能够在保护电极不受外部影响的情况下，仍能在植入时拥有较好的观察视野，且在固定时，由于是栅栏式的结构设计，因此可在底部俩端进行牙科水泥的浇筑固定。
本实施例中，栅栏式固定件5包括至少2个固定脚，每个固定脚间隔设置。
优选地，本实施例中，栅栏式固定件5优选包括3个固定脚，每个固定脚间隔设置，每个固定脚之间的距离优选相同；需要说明的是，栅栏式固定件5包括3个固定脚仅是本实施例的一种优选，在其他实施例中，栅栏式固定件5可以包括2个、4个或5个固定脚。
本实施例中，第一连接件6包括第一凹槽10和第二凹槽11，第二连接件8包括第一凸起12，所述第三连接件9包括第二凸起13，第一凸起12与第一凹槽10插接配合，用于使第一盖板2固定在主体1的顶部，第二凸起13与第二凹槽11插接配合，用于使第二盖板3固定在主体1的顶部。
具体地，第一凹槽10和第二凹槽11均优选设置在主体1的顶部，第一凹槽10作为第一盖板2的插入端、用于固定第一盖板2，第二凹槽11作为第二盖板3的插入端、用于固定第二盖板3。第一凸起12用于插入第一凹槽10，使第一盖板2固定在主 体1顶部，第二凸起13用于插入第二凹槽11，使第二盖板3固定在主体1顶部。
本实施例中，第一凸起12包括中空的结构，第二凸起13包括中空的结构。
具体地，第一凸起12为第一盖板2与主体1的固定装置，第二凸起13为第二盖板3与主体1的固定装置，第一凸起12和第二凸起13均采取挖空设计、用于减轻电极保护装置整体的重量。
本实施例中，第一凹槽10和第二凹槽11均为半圆柱形槽体，第一凸起12包括与第一凹槽10互相配合的半圆柱形凸起，第二凸起13包括与第二凹槽11互相配合的半圆柱形凸起。
本实施例中，第一盖板2的横截面形状包括半圆形，第二盖板3的横截面形状包括半圆形，腔体4的横截面形状包括圆形，第一盖板2和第二盖板3互相接触、构成与腔体4的横截面形状吻合的圆形。
本实施例中，插入口7的形状包括矩形。
需要说明的是，插入口7的形状包括矩形仅是本实施例的一种优选，在其他实施例中，插入口7的形状可以包括圆形、椭圆形、三角形或菱形。
本实施例中，待检测部包括鼠类的头骨。
优选地，本装置的所有零件均采用3D打印技术进行制造。具体地，在电极植入后，主体1底部的栅栏式固定件5与实验鼠的头骨进行固定之后，将第一盖板2上的第一凸起12插装至主体1顶部的第一凹槽10中、使第一盖板2固定在主体1顶部，将第二盖板3上的第二凸起13插装至主体1顶部的第二凹槽11中、使第二盖板3固定在主体1顶部，以完成组装。由于第一盖板2上的第一凸起12与主体1顶部的第一凹槽10为间隙配合，以及第二盖板3上的第二凸起13与主体1顶部的第二凹槽11为间隙配合，因此在完成植入手术后需要将其使用胶布粘连，且无需使用较多胶带粘连，能够避免在取下胶带时产生较大扭矩的现象，避免产生松动。且headstage的插入口7也需要胶带封闭，防止灰尘落入，待需要插入headstage接口时，再取下胶带。本发明能够极大程度上避免术后动物对电极的破坏，且在脑电数据采集之前，仅需将第一盖板2和第二盖板3的少量胶带撕开即可，取代了传统胶带保护，避免了在撕开胶带时产生大扭矩导致的电极脱落。
优选地，在其他优选的实施例中，主体1上还能集成有屏蔽装置，从而形成更全面的屏蔽场，以抵消噪音对脑电信号的影响。
与现有技术相比，本实施例提供的一种电极保护装置，能够解决在实验过程中电 极被实验动物撕咬，以及受到灰尘污染等一些影响电生理信号的问题，能够减轻电极保护装置的重量以及提高电极保护装置的便捷性，进一步减轻记录装置整体的重量，还能增加植入电极时的观察视野，有利于观察电极的进入姿态，还有利于将电极保护装置和小鼠头部进行固定，使电极保护装置能够更稳定地固定在小鼠的头部，能够避免电极保护装置晃动导致电极在小鼠脑中发生偏移或者移动，有利于提高实验数据的准确性。
本领域技术人员可以理解附图只是一个优选实施场景的示意图，附图中的模块或流程并不一定是实施本发明所必须的。
本领域技术人员可以理解实施场景中的装置中的模块可以按照实施场景描述进行分布于实施场景的装置中，也可以进行相应变化位于不同于本实施场景的一个或多个装置中。上述实施场景的模块可以合并为一个模块，也可以进一步拆分成多个子模块。
上述本发明序号仅仅为了描述，不代表实施场景的优劣。
以上公开的仅为本发明的几个具体实施场景，但是，本发明并非局限于此，任何本领域的技术人员能思之的变化都应落入本发明的保护范围。
Claims (10)
- 一种电极保护装置，其特征在于，包括：主体、第一盖板和第二盖板，所述主体内具有腔体，用于安装记录电极，所述主体底部具有栅栏式固定件，所述栅栏式固定件用于固定于待检测部；所述主体上设置有第一连接件，所述第一盖板上设置有插入口和第二连接件，所述插入口用于插入headstage接口，所述第二盖板上设置有第三连接件；所述第二连接件与所述第一连接件插接连接、用于使所述第一盖板固定在所述主体的顶部，所述第三连接件与所述第一连接件插接连接、用于使所述第二盖板固定在所述主体的顶部。
- 根据权利要求1所述的电机保护装置，其特征在于：所述栅栏式固定件的横截面形状包括圆形。
- 根据权利要求1所述的电机保护装置，其特征在于：所述栅栏式固定件包括至少2个固定脚，每个所述固定脚间隔设置。
- 根据权利要求1所述的电机保护装置，其特征在于：所述第一连接件包括第一凹槽和第二凹槽，所述第二连接件包括第一凸起，所述第三连接件包括第二凸起；所述第一凸起与所述第一凹槽插接配合，用于使所述第一盖板固定在所述主体的顶部，所述第二凸起与所述第二凹槽插接配合，用于使所述第二盖板固定在所述主体的顶部。
- 根据权利要求4所述的电机保护装置，其特征在于：所述第一凸起包括中空的结构；所述第二凸起包括中空的结构。
- 根据权利要求4所述的电机保护装置，其特征在于：所述第一凹槽和所述第二凹槽均为半圆柱形槽体；所述第一凸起包括与所述第一凹槽互相配合的半圆柱形凸起，所述第二凸起包括与所述第二凹槽互相配合的半圆柱形凸起。
- 根据权利要求1所述的电机保护装置，其特征在于：所述第一盖板的横截面形状包括半圆形，所述第二盖板的横截面形状包括半圆形，所述腔体的横截面形状包括圆形；所述第一盖板和所述第二盖板互相接触、构成与所述腔体的横截面形状吻合的圆形。
- 根据权利要求1所述的电机保护装置，其特征在于：所述插入口的形状包括矩形。
- 根据权利要求1所述的电机保护装置，其特征在于：所述插入口的形状包括圆形、椭圆形、三角形或菱形。
- 根据权利要求1所述的电机保护装置，其特征在于：所述待检测部包括鼠类的头骨。
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| WO2016080652A1 (ko) * | 2014-11-19 | 2016-05-26 | 전남대학교병원 | 동물의 실험부위 보호장치 |
| CN212232648U (zh) * | 2020-05-18 | 2020-12-29 | 宁波大学 | 可拆卸的啮齿类动物社交能力行为检测装置 |
| CN112545704A (zh) * | 2020-12-10 | 2021-03-26 | 中国科学院深圳先进技术研究院 | 一种大小鼠头部植入型固定器 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016080652A1 (ko) * | 2014-11-19 | 2016-05-26 | 전남대학교병원 | 동물의 실험부위 보호장치 |
| CN212232648U (zh) * | 2020-05-18 | 2020-12-29 | 宁波大学 | 可拆卸的啮齿类动物社交能力行为检测装置 |
| CN112545704A (zh) * | 2020-12-10 | 2021-03-26 | 中国科学院深圳先进技术研究院 | 一种大小鼠头部植入型固定器 |
Non-Patent Citations (1)
| Title |
|---|
| MA XIAO-YU ，, ZHANG YI-YAO, WANG LI-NA, LIN LONG-NIAN: "Multi-channel in vivo recording technique: Microdrive array fabrication and electrode implantation in mice", ACTA PHYSIOLOGICA SINICA., vol. 65, no. 6, 25 December 2013 (2013-12-25), pages 637 - 646, XP093071500, DOI: 10.13294/j.aps.2013.06.007 * |
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