WO2023096715A3 - Immunomodulatory glycosphingolipids and methods of use thereof - Google Patents
Immunomodulatory glycosphingolipids and methods of use thereof Download PDFInfo
- Publication number
- WO2023096715A3 WO2023096715A3 PCT/US2022/047392 US2022047392W WO2023096715A3 WO 2023096715 A3 WO2023096715 A3 WO 2023096715A3 US 2022047392 W US2022047392 W US 2022047392W WO 2023096715 A3 WO2023096715 A3 WO 2023096715A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- compounds
- alpha
- activity
- immunomodulatory
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000002339 glycosphingolipids Chemical class 0.000 title 1
- VQFKFAKEUMHBLV-BYSUZVQFSA-N 1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQFKFAKEUMHBLV-BYSUZVQFSA-N 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 210000000581 natural killer T-cell Anatomy 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided herein are a subset of alpha-galactosylceramide (alpha-GC) compounds having improved immunomodulatory activity, particularly with respect to NKT cell number and activity. Also provided herein are methods of use of such compounds, including in the modulation of NKT cells and/or activity in vivo. Further provided are combinatorial synthesis methods for generating alpha-GC compounds of specifically defined structure and thereby generating pure preparations thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163270959P | 2021-10-22 | 2021-10-22 | |
| US63/270,959 | 2021-10-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2023096715A2 WO2023096715A2 (en) | 2023-06-01 |
| WO2023096715A9 WO2023096715A9 (en) | 2023-07-20 |
| WO2023096715A3 true WO2023096715A3 (en) | 2023-09-28 |
Family
ID=86540268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2022/047392 WO2023096715A2 (en) | 2021-10-22 | 2022-10-21 | Immunomodulatory glycosphingolipids and methods of use thereof |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2023096715A2 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060052316A1 (en) * | 2004-08-27 | 2006-03-09 | Porcelli Steven A | Ceramide derivatives as modulators of immunity and autoimmunity |
| WO2012018950A1 (en) * | 2010-08-03 | 2012-02-09 | Beth Israel Deaconess Medical Center | Methods and compositions for treatment of metabolic disorders |
| US20150252068A1 (en) * | 2012-10-12 | 2015-09-10 | The Brigham And Women's Hospital, Inc. | Glycosphingolipids and methods of use thereof |
| WO2020167403A1 (en) * | 2019-02-11 | 2020-08-20 | President And Fellows Of Harvard College | Immunomodulatory glycosphingolipids and methods of use thereof |
-
2022
- 2022-10-21 WO PCT/US2022/047392 patent/WO2023096715A2/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060052316A1 (en) * | 2004-08-27 | 2006-03-09 | Porcelli Steven A | Ceramide derivatives as modulators of immunity and autoimmunity |
| WO2012018950A1 (en) * | 2010-08-03 | 2012-02-09 | Beth Israel Deaconess Medical Center | Methods and compositions for treatment of metabolic disorders |
| US20150252068A1 (en) * | 2012-10-12 | 2015-09-10 | The Brigham And Women's Hospital, Inc. | Glycosphingolipids and methods of use thereof |
| WO2020167403A1 (en) * | 2019-02-11 | 2020-08-20 | President And Fellows Of Harvard College | Immunomodulatory glycosphingolipids and methods of use thereof |
Non-Patent Citations (1)
| Title |
|---|
| DATABASE PUBCHEM SUBSTANCE ANONYMOUS : "HexCer-NDS d30:0", XP093096763, retrieved from PUBCHEM * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023096715A9 (en) | 2023-07-20 |
| WO2023096715A2 (en) | 2023-06-01 |
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