WO2023088405A1 - Bouteille de collecte d'échantillon liquide, appareil de collecte d'échantillon liquide et appareil de test - Google Patents

Bouteille de collecte d'échantillon liquide, appareil de collecte d'échantillon liquide et appareil de test Download PDF

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Publication number
WO2023088405A1
WO2023088405A1 PCT/CN2022/132766 CN2022132766W WO2023088405A1 WO 2023088405 A1 WO2023088405 A1 WO 2023088405A1 CN 2022132766 W CN2022132766 W CN 2022132766W WO 2023088405 A1 WO2023088405 A1 WO 2023088405A1
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WO
WIPO (PCT)
Prior art keywords
liquid sample
liquid
bottle
sample collection
wall
Prior art date
Application number
PCT/CN2022/132766
Other languages
English (en)
Chinese (zh)
Inventor
王中平
Original Assignee
艾康生物技术(杭州)有限公司
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Publication of WO2023088405A1 publication Critical patent/WO2023088405A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • G01N2001/1472—Devices not actuated by pressure difference
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • G01N2001/1472—Devices not actuated by pressure difference
    • G01N2001/149—Capillaries; Sponges

Definitions

  • the invention belongs to the technical field of medical devices, and further belongs to the field of medical testing, in particular to a liquid sample collection bottle, a liquid sample collection device and a detection device.
  • lateral flow immunoassay devices that can be used to detect the presence of analytes in samples, such as hormones, sugars, adulterants, drugs of abuse (including injecting or smoking drugs), etc.
  • a liquid sample is collected and added to a lateral flow immunoassay device to detect a certain or certain components in the liquid sample.
  • the liquid sample can be any volume of liquid for testing, inspection or research.
  • the liquid sample can come from any liquid, such as body fluid, such as saliva or blood or urine or other liquids to be tested, such as water samples from pollution sources, liquid samples from beverages, etc.
  • Liquid samples are typically collected and absorbed using a sampling stick having a collecting element formed of absorbent material such as a pad or sponge, which is attached to one end of a plunger.
  • the collection element allows a sufficient volume of sample liquid to be absorbed from the liquid source, the presence of sample liquid in the collection element causing the interior of the collection element to expand.
  • the collection element typically retains the sample until operation of the collection element releases the sample.
  • the prior art usually squeezes the liquid sample out of the collection element of the sampling stick, and then adds it to the detection device (such as a lateral flow immunoassay device) for detection; or in some detections , It is also necessary to pretreat the extruded liquid sample with a buffer solution such as mixing/lysing, and then add it to the detection device for detection.
  • the detection device such as a lateral flow immunoassay device
  • the collection bottle is used to collect the liquid sample on the collection element, that is, the collection element end of the sampling rod is inserted into the collection bottle, and the collection element is pressed against the side wall or bottom of the collection bottle to make the liquid sample flow out into a collection bottle for sample collection.
  • One of the objectives of the present invention is to provide a liquid sample collection bottle for collecting human or animal liquid samples to address the deficiencies in the prior art.
  • a liquid sample collection bottle comprising a bottle body with an opening, the bottle body includes an inner wall and an outer wall, the inner wall includes a cylindrical part, wherein: the cylindrical part of the inner wall of the bottle is provided with a guide groove extending downward from the opening, the The guide groove includes a top-down slope and a spiral descending part.
  • the cross-section of the guide groove is rectangular, triangular, trapezoidal or arc-shaped, and the part with a larger cross-sectional size of the guide rail is located on the inner wall of the bottle body.
  • the guide groove includes a vertical portion and a top-down inclined portion.
  • the slope of the guide groove is a straight line or a smooth curve.
  • the slope of the smooth curve decreases sequentially from top to bottom.
  • the guide groove further includes a horizontal surrounding portion communicating with the bottom of the inclined portion of the guide groove.
  • the present invention also includes a backing plate placed in the bottle, and the backing plate is provided with through holes for the passage of liquid samples.
  • the upper surface of the backing plate is provided with protrusions or depressions.
  • the guide rail spirally descends one-sixth to one week of the inner wall of the bottle.
  • the second object of the present invention is to provide a device for collecting liquid samples for collecting liquid samples from humans or animals in view of the deficiencies in the prior art.
  • a device for collecting liquid samples including a liquid sample collection bottle and a sampler
  • the liquid sample collection bottle includes a bottle body with an opening
  • the bottle body includes an inner wall and an outer wall
  • the inner wall includes a cylindrical part
  • the sampler includes a rod part and a liquid-absorbing part
  • the liquid-absorbing part is connected to the lower end of the rod part
  • the cylindrical part of the inner wall of the bottle is provided with a guide groove extending downward from the opening, so
  • the guide groove includes a part that slopes from top to bottom and spirals down.
  • the lower end of the rod is provided with a guide rail.
  • the guide rail at the lower end of the rod cooperates with the guide groove on the inner wall of the bottle. , leading the lower end of the rod portion of the sampler to spirally descend in the liquid sample collection bottle.
  • the cross-section of the guide groove on the inner wall of the bottle is rectangular, triangular, trapezoidal or arc-shaped, and the part with a larger cross-sectional size of the guide rail is located on the inner wall of the bottle body.
  • the guide groove includes a vertical part and a top-down inclined part.
  • the slope of the guide groove is a straight line or a smooth curve.
  • the slope of the smooth curve decreases sequentially from top to bottom.
  • the guide groove further includes a horizontal surrounding portion communicating with the bottom of the inclined portion of the guide groove.
  • the present invention also includes a backing plate placed in the liquid sample collection bottle, the backing plate is provided with a through hole to facilitate the passage of the liquid sample, and the lower end of the rod portion of the sampler spirally descends in the liquid sample collection bottle During the process, the backing plate wrings or squeezes the suction portion of the sampler.
  • the backing plate and the dipping part of the sampler are provided with protrusions and depressions that cooperate with each other.
  • the bottom of the dipping part is hardened so that it has a higher hardness compared to other parts of the dipping part, which is more conducive to reducing the bottom of the dipping part and the upper surface of the backing plate. slippage between.
  • the guide groove spirally descends one-sixth to one week of the inner wall of the liquid sample collection bottle.
  • the cooperating guide rails and guide grooves are a pair, or two, three, four, five or six pairs evenly distributed.
  • the third object of the present invention is to provide a method for collecting liquid samples for collecting human or animal liquid samples in view of the deficiencies in the prior art.
  • a method for collecting a liquid sample providing a device for collecting a liquid sample, the device for collecting a liquid sample includes a sampler and a liquid sample collecting part, and an inclined and spiral descending guide is provided between the sampler and the liquid sample collecting part
  • the mechanism is used to guide the sampler to descend spirally in the liquid sample collecting part, and the method includes the following steps:
  • the sampler is reversely spiraled up, the sampler is taken out, and the liquid sample collection part is sealed.
  • the device for collecting liquid samples is as disclosed in the second invention.
  • the fourth object of the present invention is to provide a detection device for collecting liquid samples of people or animals in view of the deficiencies in the prior art.
  • a detection device comprising a device for collecting liquid samples and a detection plate
  • the device for collecting liquid samples includes a liquid sample collecting part and a sampler
  • the liquid sample collecting part includes a cylindrical inner wall
  • the sampler includes a rod part and a liquid suction part
  • the liquid-absorbing part is connected to the lower end of the rod part
  • the cylindrical part of the inner wall of the bottle is provided with a guide groove extending downward from the opening, and the guide groove includes a part inclined and spirally descending from top to bottom, and the rod There is a guide rail at the lower end of the sampler.
  • the detection plate After the lower end of the rod of the sampler is inserted into the liquid sample collection bottle, the guide rail at the lower end of the rod cooperates with the guide groove on the inner wall of the bottle to guide the lower end of the rod of the sampler to spiral down in the liquid sample collection bottle. , and then squeeze or squeeze the liquid-absorbing part of the sampler, the detection plate includes a detection component, and the detection component is used to give the detection result information.
  • the liquid sample collecting part and the detection plate or parts of the detection plate are independent components separated from each other.
  • the liquid sample collection component is mounted on the detection board or a component of the detection board.
  • a guide groove extending downward from the opening is provided on the inner wall of the liquid sample collection bottle, and the guide groove includes a part inclined and spirally descending from top to bottom.
  • the liquid part draws enough liquid samples, it is inserted into the sampling bottle.
  • the lower end of the rod part of the guide sampler drives the liquid extraction part to perform a spiral downward movement in the sampling bottle, and then the liquid extraction is carried out.
  • the part produces a squeezing effect similar to that of wringing a wet towel, so as to fully squeeze out the liquid sample drawn by the liquid absorbing part.
  • the present invention has a higher liquid sample extrusion rate, and can squeeze out more liquid samples for detection when the same liquid sample is drawn by the suction part, so that it is easier to meet the detection requirements.
  • the minimum amount of liquid samples thereby improving the success rate of detection and the accuracy of detection results.
  • Fig. 1 is a schematic plan view of a liquid sample collection bottle of the present invention.
  • FIG. 2 is a schematic cross-sectional view along line A-A of FIG. 1 .
  • Fig. 3 is a schematic plan view of the backing plate in the liquid sample collection bottle of the present invention.
  • FIG. 4 is a top view of FIG. 1 .
  • Fig. 5 is a schematic plan view of the device for collecting liquid samples of the present invention (the sampler is not inserted into the liquid sample collection bottle).
  • FIG. 6 is a schematic partial cross-sectional view along the line A-A of FIG. 5 .
  • Figure 7 is similar to Figure 5, but with the sampler inserted into the liquid sample collection bottle in its initial position (the dip has not been squeezed).
  • FIG. 8 is a schematic cross-sectional view along line A-A of FIG. 7 .
  • FIG. 9 is a partially enlarged schematic view of portion "A" along the direction C-C in FIG. 8 .
  • 10-12 are schematic diagrams of modified designs of FIG. 9 .
  • Fig. 13 is a partially developed plan view of the cylindrical part of the inner wall of the liquid sample collection bottle of the present invention.
  • FIG. 14 is a schematic diagram of a modified design of FIG. 13 .
  • Figure 15 is similar to Figure 7, but with the sampler inserted into the final position in the liquid sample collection bottle (with the dip fully squeezed).
  • Fig. 16 is a schematic cross-sectional view along the line A-A of Fig. 15 .
  • FIG. 17 is a schematic diagram of a modified design of FIG. 2 .
  • Fig. 18 is similar to Fig. 7, but the liquid sample collection bottle has the structure shown in Fig. 17 .
  • FIG. 19 is an enlarged schematic view of part “B” in FIG. 18 .
  • Fig. 20 is a modified design diagram of Fig. 8, showing another modified design of the present invention.
  • FIG. 21 is a partially enlarged schematic diagram of FIG. 20 .
  • Fig. 22 is a modified design diagram of Fig. 21.
  • 23-28 are six specific embodiments of the sampling stick of the present invention.
  • Fig. 29 and Fig. 30 are modified design diagrams of Fig. 13 .
  • Fig. 31 and Fig. 32 are modified design diagrams of Fig. 14 .
  • Fig. 33 is a schematic diagram of the use state of the detection device of the present invention.
  • FIG. 34 is a schematic diagram of the detection results of the detection board shown in FIG. 33 .
  • Fig. 35 is a schematic diagram of the use state of another embodiment of the detection device of the present invention.
  • FIG. 36 is a schematic diagram of the detection results of the detection board shown in FIG. 35 .
  • the cylinder of the present invention refers to a hollow cylinder or hollow barrel whose cross-section is circular or approximately circular, and the areas of each cross-section are equal or approximately equal; the cylinder of the present invention also includes cut Hollow cone with truncated apex, that is, the longitudinal section through its axis is an isosceles trapezoid or approximately isosceles trapezoid, but the angle between the hypotenuse and the height of the trapezoid is preferably not more than fifteen degrees, but Nor is it limited to fifteen degrees.
  • the hollow column or hollow cone that achieves the beneficial effects of the present invention are all included in the cylinder of the present invention. In the range.
  • Cylindrical part The part whose shape or structure is a cylinder of the present invention.
  • Liquid sample collection bottle also known as a liquid sample collection part, refers to a bottle-shaped object, a cup-shaped object, a cylindrical object, and any shape or part of an object with a cylindrical inner wall for collecting liquid samples.
  • Spiral descent also known as spiral descent, that is, on the inner wall of the cylinder, it gradually descends in the form of a spiral from a high place to a low place, forming a three-dimensional smooth curve trajectory.
  • the spiral can be from a fraction of a turn to a turn or several turns.
  • Rectangle, triangle, trapezoid including not only the rectangle, triangle, and trapezoid in mathematical concepts, but also the approximate rectangle, triangle, and trapezoid.
  • Forward refers to the direction opposite to the reverse, but forward does not specifically refer to the clockwise direction, but refers to one of the clockwise or counterclockwise directions.
  • the reverse direction refers to the counterclockwise direction; otherwise, when the forward direction refers to the counterclockwise direction, the reverse direction refers to the clockwise direction.
  • Squeeze Squeeze while twisting, that is, the two ends of the object rotate in opposite directions when they are close to each other, producing an effect similar to wringing a wet towel.
  • the liquid-absorbing part is fully squeezed: it means that under normal manpower, the liquid-absorbing part is squeezed to achieve the effect of basically draining the liquid in the liquid-absorbing part (the liquid discharge rate is obviously higher than that of the prior art) .
  • the present invention provides a liquid sample collection bottle 10, which is used to collect liquid samples such as saliva, blood, urine, sweat, etc. (including immunological detection methods and non-immunological detection methods) to detect the content of a certain substance or substances in these liquid samples, so as to obtain the physiological parameter indicators of the tested human body or animal.
  • liquid samples such as saliva, blood, urine, sweat, etc.
  • immunological detection methods and non-immunological detection methods to detect the content of a certain substance or substances in these liquid samples, so as to obtain the physiological parameter indicators of the tested human body or animal.
  • coronavirus pneumonia Taking the detection of new coronavirus pneumonia as an example, scientists have developed products and detection methods that use human or animal saliva (including processed) as samples to determine whether the human body or animal that provided the saliva sample is infected with the new coronavirus. Coronavirus pneumonia.
  • One of the important links of the detection method is how to collect the saliva of the human body or animal to be tested.
  • the object of the present invention is to provide a novel liquid sample collection bottle for collecting human or animal saliva, a device for collecting liquid samples, a detection device, and a method for collecting liquid samples using the device for collecting liquid samples.
  • the invention can be used for the detection of novel coronavirus pneumonia.
  • Invention 1 Liquid sample collection bottle
  • the liquid sample collecting bottle 10 of the present invention comprises the bottle body 12 that has opening 11, and bottle body 12 comprises inner wall 14 and outer wall 16, and inner wall 14 comprises cylindrical portion 18 (that is, at least the inner wall 14 A part is a cylindrical structure), and the cylindrical part 18 is provided with a guide groove 20 inclined and spirally descending from the opening 11 from top to bottom.
  • the guide groove 20 inclined from top to bottom and spirally descending according to the present invention includes at least the following structures: A, the whole section from the starting point to the end point is all spiral descending part 20b (as shown in Figure 29 and Figure 31); B, from the opening 11 of the bottle body, a vertical descending portion 20a extending vertically downward for an appropriate distance and a spiral descending portion 20b communicating with the vertical descending portion 20a (as shown in Figures 2, 6, 13, and 14); C, from the opening 11 of the bottle body a vertical descending portion 20a extending vertically downward for an appropriate distance, a spiral descending portion 20b communicating with the vertical descending portion 20a and a horizontal surrounding portion 20c communicating with the spiral descending portion 20b ( As shown in Figure 17); and D, the spiral descending portion 20b descending from the opening 11 of the bottle and the horizontal surrounding portion 20c (as shown in Figures 30 and 32 ) communicated with the spiral descending portion 20b.
  • the guide groove 20 is a groove recessed to the inner wall 14 by an appropriate distance, and is attached to the inner wall 14 as a helical disk.
  • the cross-section of the guide groove 20 is rectangular (including square), triangular, trapezoidal or arc-shaped (including partly circular or partly elliptical), and the cross-sectional size of the guide groove 20 is relatively large
  • the part (as shown by the dotted lines in FIGS. 9-12 ) is located on the inner wall 14 of the bottle body 12 .
  • the spiral descending portion 20b on the inner wall 14 is a straight line inclined from top to bottom (as shown in Figures 13, 29, and 31). , the angle “A" between it and the horizontal plane is greater than or equal to 30 degrees and less than or equal to 75 degrees, and the preferred angle “A” is 60 degrees or 45 degrees.
  • the spiral descending portion 20b on the inner wall 14 is a smooth curve inclined from top to bottom (as shown in Figures 14, 31, and 32). The slope of the curve decreases successively from top to bottom (that is, the angle between the tangent of the smooth curve and the horizontal plane gradually decreases).
  • the angle "C" between the tangent line at the top of the guide groove 20 and the horizontal plane is 75 degrees
  • the angle "B” between the tangent line at the bottom of the guide groove 20 and the horizontal plane is 30 degrees.
  • the liquid sample collection bottle 10 further includes a backing plate 22 placed in the bottle body 12 .
  • the backing plate 22 is provided with several through holes 24 to facilitate the flow of liquid samples.
  • the backing plate 22 is in the shape of a disc with a thickness of about 2.0-5.0 mm and is usually made of hard plastic.
  • the bottle body 12 includes an upper part and a lower part. The size of the upper part is obviously larger than that of the lower part.
  • a shoulder 26 is formed at the junction of the two parts. The backing plate 22 is placed on and supported by the shoulder 26 .
  • FIG. 3 is a top plan view of the backing plate 22
  • FIG. 4 is a top plan view of the backing plate 22 after being placed in the bottle body 12 .
  • a depression 30 (as shown in FIG. 21 , the depression may also be a through hole 24 as shown in FIG. 3 ) or a protrusion 28 (as shown in FIG. 22 ) is provided on the upper surface of the backing plate 22 .
  • the guide groove 20 spirally descends at least one-sixth of the circle of the inner wall 18 of the bottle, but preferably no more than one circle (not necessarily no more than one circle, in some cases, it can also be several circles).
  • One guide groove 20 can be set on the inner wall 18 of the cylinder part, and two, three, four, five and six guide grooves 20 can also be evenly set, but the quantity of guide grooves 20 should not limit the scope of the present invention. protected range.
  • the present invention also provides a liquid sample collection device 100, the liquid sample collection device 100 includes the liquid sample collection bottle 10 as described in Invention 1 (in order to avoid repetition, Invention 1
  • the contents of the invention are all incorporated into the second invention, and the specific structure of the liquid sample collection bottle 10) and the sampler 50 will not be described in detail in the second invention.
  • the sampler 50 includes a stem 52 and a dip 56 connected to a lower end 54 of the stem.
  • the liquid-absorbing part 56 is made of a material with excellent water absorption and drainage properties, such as sponge, absorbent cotton, gauze, special fiber and the like.
  • Rod 52 is made of hard material, and the lower end 54 of the rod is round cake-shaped, and its periphery is provided with protruding guide rail 58, and the shape and size of this guide rail 58 are corresponding to guide groove 20 on the bottle inner wall 14 (Fig. 5 and the guide rail 58 shown in Figure 6 are inclined, and the direction of inclination is consistent with the guide groove 20), the size of the lower end 54 of the bar is adapted to the space surrounded by the bottle inner wall 14, so that the guide rail 58 can Free sliding in the guide groove 20 enables the guide rail 20 and the guide groove 58 to cooperate with each other to play the role of guiding the lower end 54 of the rod part to spirally descend.
  • the guide rail 58 of the lower end 54 of the rod portion cooperates with the guide groove 20 on the inner wall 14 of the bottle, and guides the lower end 54 of the rod portion of the sampler 50 in the liquid sample collection bottle 10. Spiral descending inside liquid sample collection bottle.
  • the surface friction between the two reduces the relative sliding of the bottom of the dipping portion 56 relative to the pad portion 22, while the guide groove 20 guides the lower end of the stem portion.
  • the liquid sample is discharged from the liquid drawing part 56 into the liquid sample collection bottle 10, and mixed with the lysate 60 (as shown in Figure 8) in the collection bottle to form a mixed solution 62 of the lysate and the liquid sample (as shown in Figure 16 ).
  • the guide groove of smooth curve is favorable when starting to descend, the guide groove 20 and the guide rail 58 guide the lower end 54 of the rod portion to accelerate the descending speed, thereby exerting a stronger downward extrusion on the dipping portion, while in the When approaching the end of the descent, the guide groove 20 and the guide rail 58 guide the lower end 54 of the rod part to produce a stronger twist, thereby producing a better wringing effect on the liquid drawing part 56, and squeezing out more liquid samples from the liquid drawing part 56 .
  • Both can be provided with depression 30 (this depression also can be through hole 24) on the upper surface of backing plate 22 and be provided with protrusion 28 (as shown in Figure 21) at the bottom of the dipping part 56 of sampler, also can be on backing plate
  • the upper surface of the sampler 22 is provided with a protrusion 28 and a depression 30 (as shown in Figure 22 ) at the bottom of the dipping portion 56 of the sampler, or the bottom of the dipping portion 56 and the upper surface of the backing plate 22 are made rough. , to increase the friction between the two.
  • the bottom of the dipping portion 56 is hardened so that it has a higher hardness compared to other parts of the dipping portion, so that it is more conducive to reducing the gap between the bottom of the dipping portion 56 and the upper surface of the backing plate 22.
  • the sliding between them improves the squeezing effect on the liquid drawing part 56, and further improves the discharge rate of the liquid sample from the liquid drawing part 56.
  • the guide rail 58 on the lower end 54 of the rod portion of the sampler 50 there is one guide rail 58 on the lower end 54 of the rod portion of the sampler 50 , and at this time, the guide groove 20 and the guide rail 58 are a pair.
  • the guide rails 58 on the lower end 54 of the rod portion of the sampler 50 may be two, three, four, five or six evenly distributed, Then the guide grooves 20 and the guide rails 58 that cooperate with each other at this time are two pairs, three pairs, four pairs, five pairs or six pairs respectively, which can improve the twisting effect on the liquid-absorbing portion 56 and further improve the flow rate from the liquid-absorbing portion 56. Efficiency of twisting out liquid samples.
  • the distance "L” between the bottom of the horizontal surrounding portion 20c of the guide groove and the upper surface of the backing plate 22 is greater than or equal to 2.5 millimeters and less than or equal to 35.0 millimeters, and this distance "L” enables sampling
  • the guide rail 58 of the lower end 54 of the rod part of the device 50 is kept buckled on the horizontal surrounding part 20c (as shown in Fig. 17 and Fig. 18 ).
  • the advantage of such a design is that the liquid-absorbing part 56 can still be kept in a twisted and compressed state after the operator lets go.
  • the liquid sample collection bottle 10 of the present invention can also be integrated with the detection device 210 (including the two are formed integrally and the two are formed separately and then assembled into one body).
  • the liquid sample collection bottle 10 of the present invention can be formed on the existing detection device 210 , so that the liquid sample collection bottle 10 of the present invention becomes the liquid sample receiving part of the detection device 210 .
  • the guide groove 20 according to the present invention is set on the cylindrical inner wall of the liquid sample receiving part of the existing detection device, and the guide groove 20 cooperates with the guide rail 58 at the lower end of the sampler 10 to guide the draw of the sampler 10.
  • the liquid part 56 produces a wringing effect, thereby improving the liquid sample discharge rate of the liquid drawing part 56 .
  • the liquid sample collection bottle 10 of the present invention can be an independent bottle-shaped structure, or can be a part of the sample receiving part formed on the detection device.
  • Invention 3 A method for collecting liquid samples
  • the present invention also provides a method for collecting a liquid sample.
  • the method provides the liquid sample collecting part 10 and the sampler 50 as disclosed in the first and second inventions above.
  • the guide mechanism for spiral descent is used to guide the sampler 50 to descend spirally in the liquid sample collection part 10 .
  • the method comprises the steps of:
  • the sampler 50 is spiraled upward in reverse, the sampler 50 is taken out, and the liquid sample collection bottle 10 is sealed.
  • the guiding mechanism includes guide rails 20 and guide grooves 58 (or guide grooves 20 and guide rails 58 ) respectively arranged at the lower ends of the rods of the liquid sample collecting part 10 and the sampler 50 .
  • Invention 4 A detection device
  • FIG. 33 and 34 show the use status and detection results of a detection device of the present invention.
  • the detection device 200 includes a device 100 for collecting liquid samples (the structure is as described in "Invention 2", the difference is that a cap 11 is added) and a detection plate 210 .
  • the device 100 for collecting a liquid sample includes a liquid sample collecting part 10 and a sampler 50 (the sampler 50 is omitted in FIG. 33 ), wherein the liquid sample collecting part 10 includes a cylindrical inner wall 14, and the sampler 50 includes a rod part 52 and a liquid-absorbing part. 56 , the dipping part 56 is connected to the lower end 54 of the rod part.
  • the cylindrical inner wall 14 is provided with a guide groove 20 inclined and spirally descending from top to bottom, and a guide rail 58 is provided at the lower end 54 of the rod.
  • the guide rail 58 at the lower end of the rod part cooperates with the guide groove 20 on the inner wall of the cylinder to guide the lower end 54 of the rod part of the sampler to descend spirally in the liquid sample collecting part 10. , and then wring or extrude the dipping portion 56 of the sampler.
  • the detection board 210 includes a detection component 220, and the detection component 220 is used for giving detection result information.
  • the test board 210 is provided with a sample loading area 212 and a test result display area 214 for observing the test results.
  • the detection part 220 has a T line and a C line in the detection result display area 214, and the T line and the C line are invisible before detection. Within a period of time after the detection, the following situations generally occur: A. If the C line is not displayed (whether the T line is displayed or not), it means that the detection has failed; B. If the C line is displayed, but the T line is not displayed, it means that the detection The result is negative; C, showing both the C line and the T line, it means that the test result is positive, and the T line is thick, it is strong positive, and the T line is weak, it is weak positive.
  • the liquid sample collection part 10 and the detection plate 210 or parts of the detection plate 210 are independent components separated from each other, and the structures of the liquid sample collection part 10 and the sampler 50 are similar to those of "Invention 2" "basically the same.
  • the liquid sample collecting part 10 is installed on the detection board 210 or a certain part of the detection board 210 .
  • the liquid sample collection part 10 and the detection board 210 or a certain part of the detection board 210 can be manufactured separately and then assembled together, or can be integrally formed with the detection board 210 or a certain part of the detection board 210 and then assembled together , forming a whole.
  • the cylindrical inner wall 14 of the liquid sample collecting part 10 is provided with a guide groove 20 inclined and spirally descending from top to bottom.
  • the lower end 54 of the rod portion is provided with a guide rail 58 .
  • the guide rail 58 at the lower end of the rod part cooperates with the guide groove 20 on the inner wall of the cylinder to guide the lower end 54 of the rod part of the sampler to descend spirally in the liquid sample collecting part 10. , and then wring or extrude the dipping portion 56 of the sampler.
  • the basic principle and specific structure are as disclosed in "Invention 2".
  • the present invention uses a sponge stick as an example of the sampler 50 to collect human saliva, and uses the method of comparative experiment to check the beneficial effect of the present invention.
  • Step 1 Use the sponge sticks of the 10 fundamental inventions to be numbered 1-10 in sequence, and use an electronic scale accurate to one-thousandth of a gram to weigh the weight of each sponge stick before drawing liquid, and record it in "A” in the table below " column (the unit of weight is grams, the same below);
  • Step 2 Use the above 10 sponge sticks to collect the saliva of 10 volunteers. After the sponge head of the sponge stick is absorbed and saturated, weigh the weight of each sponge stick after absorbing the liquid, and record it in the following table. Column "B";
  • Step 3 Insert the above 10 sponge sticks into the existing liquid sample collection bottles, squeeze the sponge head vertically, fully squeeze out the saliva on the sponge head, and weigh the sponge head respectively , recorded in column "C" in the table below;
  • Step 4 insert the 10 sponge sticks after performing step 3 into the liquid sample collection bottle of the present invention respectively, after fully extruding the saliva on the sponge head with the method of the present invention, weigh the weight of the sponge head respectively , recorded in column "D" in the table below;
  • Step 5 use the formula in the following table to calculate respectively the amount of liquid drawn (E) of these 10 sponge sticks, the sample extrusion amount (F) using the existing method, and the sample extrusion amount (G) using the method of the present invention. ), adopt the sample extrusion percentage (H) of existing method, adopt the sample extrusion percentage (I) of the method of the present invention and the present invention improve percentage (J) relative to present method.
  • Step 6 Calculate the average value of the percentage improvement of the present invention relative to the current method.
  • the sampling amount of the sampling method of the present invention is increased by 28.67% on average compared with the current sampling method. This experiment shows that the beneficial effects of the sampling device and sampling method of the present invention are very prominent.
  • the sample collection bottle of the present invention cooperates with the sampling stick to fully collect the samples in the sampling stick, and can simultaneously complete the pretreatment steps such as sample cracking.
  • pretreatment steps such as sample cracking.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Hydrology & Water Resources (AREA)
  • Medicinal Chemistry (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne une bouteille de collecte d'échantillon liquide (10), un appareil de collecte d'échantillon liquide (100), et un appareil de test (200). L'appareil de collecte d'échantillon liquide (100) comprend une bouteille de collecte d'échantillon liquide (10) et un dispositif d'échantillonnage (50) ; une paroi interne (14) de la bouteille de collecte d'échantillon liquide (10) est pourvue d'une rainure de guidage (20) inclinée de haut en bas et descendant en spirale, et une extrémité inférieure (54) d'une partie tige du dispositif d'échantillonnage (50) est pourvue d'un rail de guidage (58). Lorsque l'extrémité inférieure (54) de la partie tige du dispositif d'échantillonnage (50) est insérée dans la bouteille de collecte d'échantillon liquide (10), le rail de guidage (58) de l'extrémité inférieure (54) de la partie tige et de la rainure de guidage (20) de la paroi interne (14) du corps de bouteille s'accouplent ensemble, pour guider l'extrémité inférieure (54) de la partie tige du dispositif d'échantillonnage (50) à descendre en spirale dans la bouteille de collecte d'échantillon liquide (10), ce qui continue à tordre et presser une partie écouvillon (56) du dispositif d'échantillonnage (50).
PCT/CN2022/132766 2021-11-19 2022-11-18 Bouteille de collecte d'échantillon liquide, appareil de collecte d'échantillon liquide et appareil de test WO2023088405A1 (fr)

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CN202111398025.8A CN114392780A (zh) 2021-11-19 2021-11-19 一种收集液体样本的收集装置及检测装置

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Publication number Priority date Publication date Assignee Title
CN114160219A (zh) * 2021-11-19 2022-03-11 艾康生物技术(杭州)有限公司 一种液体样本收集装置及检测装置
CN114392780A (zh) * 2021-11-19 2022-04-26 艾康生物技术(杭州)有限公司 一种收集液体样本的收集装置及检测装置

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JP2010038640A (ja) * 2008-08-01 2010-02-18 Sekisui Medical Co Ltd 検体容器
US20190339263A1 (en) * 2018-05-03 2019-11-07 Healgen Scientific Limited Apparatus for Collecting and Detecting an Analyte in a Fluid Sample
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