WO2023088394A3 - New crystal forms of lurbinectedin and preparation thereof - Google Patents

New crystal forms of lurbinectedin and preparation thereof Download PDF

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Publication number
WO2023088394A3
WO2023088394A3 PCT/CN2022/132675 CN2022132675W WO2023088394A3 WO 2023088394 A3 WO2023088394 A3 WO 2023088394A3 CN 2022132675 W CN2022132675 W CN 2022132675W WO 2023088394 A3 WO2023088394 A3 WO 2023088394A3
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WO
WIPO (PCT)
Prior art keywords
degrees
lurbinectedin
preparation
new crystal
crystal forms
Prior art date
Application number
PCT/CN2022/132675
Other languages
French (fr)
Chinese (zh)
Other versions
WO2023088394A2 (en
Inventor
陆彬文
张夏衡
邱小龙
刘文博
徐涛
张金凯
赵恒�
王虎
胡林
邹平
Original Assignee
江苏慧聚药业股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 江苏慧聚药业股份有限公司 filed Critical 江苏慧聚药业股份有限公司
Publication of WO2023088394A2 publication Critical patent/WO2023088394A2/en
Publication of WO2023088394A3 publication Critical patent/WO2023088394A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

A new crystal form C and a new crystal form D of Lurbinectedin; an XRPD spectrum of crystal form C has characteristic Bragg angles at 4.0 degrees, 7.8 degrees, 10.1 degrees, 11.9 degrees, 18.2 degrees and 25.4 degrees; and an XRPD spectrum of crystal form D has characteristic Bragg angles at 4.7 degrees, 7.9 degrees, 9.4 degrees, 11.9 degrees, 13.0 degrees, 16.8 degrees, 20.3 degrees, 24.6 degrees and 25.5 degrees.
PCT/CN2022/132675 2021-11-19 2022-11-17 New crystal forms of lurbinectedin and preparation thereof WO2023088394A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202111398172.5A CN115246846A (en) 2021-11-19 2021-11-19 New crystal form of rubitinid and preparation thereof
CN202111398172.5 2021-11-19

Publications (2)

Publication Number Publication Date
WO2023088394A2 WO2023088394A2 (en) 2023-05-25
WO2023088394A3 true WO2023088394A3 (en) 2023-09-21

Family

ID=83698861

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/132675 WO2023088394A2 (en) 2021-11-19 2022-11-17 New crystal forms of lurbinectedin and preparation thereof

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CN (1) CN115246846A (en)
WO (1) WO2023088394A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115246846A (en) * 2021-11-19 2022-10-28 江苏慧聚药业股份有限公司 New crystal form of rubitinid and preparation thereof
CN115304619A (en) * 2022-04-08 2022-11-08 上海皓元医药股份有限公司 Crystal form of rubitinid and preparation method thereof
CN114940682A (en) * 2022-05-18 2022-08-26 博瑞制药(苏州)有限公司 Crystal form of ribitdine, preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1564822A (en) * 2001-08-07 2005-01-12 法马马有限公司 Antitumoral analogs
WO2012062920A1 (en) * 2010-11-12 2012-05-18 Pharma Mar, S.A. Combination therapy with an antitumor alkaloid
WO2021099635A1 (en) * 2019-11-21 2021-05-27 Pharma Mar, S.A. New solid state form of lurbinectedin
CN115246846A (en) * 2021-11-19 2022-10-28 江苏慧聚药业股份有限公司 New crystal form of rubitinid and preparation thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1564822A (en) * 2001-08-07 2005-01-12 法马马有限公司 Antitumoral analogs
WO2012062920A1 (en) * 2010-11-12 2012-05-18 Pharma Mar, S.A. Combination therapy with an antitumor alkaloid
WO2021099635A1 (en) * 2019-11-21 2021-05-27 Pharma Mar, S.A. New solid state form of lurbinectedin
CN115246846A (en) * 2021-11-19 2022-10-28 江苏慧聚药业股份有限公司 New crystal form of rubitinid and preparation thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WEIMING HE; ZHIGAO ZHANG; DAWEI MA: "A Scalable Total Synthesis of the Antitumor Agents Et‐743 and Lurbinectedin", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 58, no. 12, 14 February 2019 (2019-02-14), Hoboken, USA, pages 3972 - 3975, XP072095926, ISSN: 1433-7851, DOI: 10.1002/anie.201900035 *

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CN115246846A (en) 2022-10-28
WO2023088394A2 (en) 2023-05-25

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