WO2023085912A1 - Automated apparatus for processing histological section samples - Google Patents

Automated apparatus for processing histological section samples Download PDF

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Publication number
WO2023085912A1
WO2023085912A1 PCT/MX2022/050094 MX2022050094W WO2023085912A1 WO 2023085912 A1 WO2023085912 A1 WO 2023085912A1 MX 2022050094 W MX2022050094 W MX 2022050094W WO 2023085912 A1 WO2023085912 A1 WO 2023085912A1
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WIPO (PCT)
Prior art keywords
casing
chamber
cover
samples
processing
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PCT/MX2022/050094
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Spanish (es)
French (fr)
Inventor
Jesús Raúl BELTRÁN RAMÍREZ
Xochitl Citlalli JIMENEZ ROMAN
Xochitl Maritza BECERRA GONZÁLEZ
Ma Del Rocio MACIEL ARELLANO
Victor Manuel LARIOS ROSILLO
Jose Antonio ORIZAGA TREJO
Ma Hidalia CRUZ HERRERA
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Beltran Ramirez Jesus Raul
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Publication of WO2023085912A1 publication Critical patent/WO2023085912A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Definitions

  • the present invention is related to the technical field of mechanics, electronics, biology, anatomy, medicine, immunology, pathology, physiology, cytology, nutrition, biochemistry, genetics and more specifically with histology, since it provides an automated apparatus for the processing of histological section samples.
  • Histology is a branch of biology that studies the organic tissues of animals and plants in their microscopic aspects: characteristics, composition, structure and function. For this reason , his fundamental tool is the microscope .
  • histology comes from the Greek histós which means 'fabric', 'post' or 'rod' (in the sense of "to stand”); includes the suffix or logia, which means 'study or science'. Therefore, histology studies the minimal structures that make up the organisms of living beings.
  • Plant histology deals with the analysis of plants, that is, living beings that belong to the plant kingdom. Plant histology includes the study of two fundamental tissues:
  • growth tissues which include primary and secondary tissues
  • Human histology is included in animal histology, since from the biological point of view human beings are part of the animal kingdom. However, it constitutes a specific area of interest as far as health is concerned.
  • connective or connective tissue which includes the varieties of cartilaginous tissue, bone tissue, adipose tissue and blood;
  • - epithelial tissue which is the tissue that covers the surfaces of the organism
  • Nervous tissue which refers to the neurons that transmit useful information to the organism.
  • the histological process refers to the histology techniques necessary to study tissues. It is based on a series of elementary steps. 1. Introduction, in which tissue harvesting (eg, by biopsy) takes place.
  • Fixation a process that aims to preserve the characteristics of the tissue through various techniques.
  • Cutting refers to the process of cutting hardened tissues, which are carried out with the help of an artifact called a microtome.
  • Staining it is a process that increases the contrast through staining, since many tissues are colorless under the microscope.
  • Observation refers to the process of observation and analysis carried out by the specialist through the microscope, from which it is possible to draw conclusions.
  • Histology is of vital importance to understand the functioning of living organisms, which has repercussions for medical and scientific research in general, and even for the economy.
  • none of the documents show an apparatus that allows the processing of histological samples by filling a chamber where the samples are placed, through a mechanism of hydraulic pumps, in addition to having a gas extraction and filtering mechanism. of the camera .
  • the objective of the present invention is to provide an automated apparatus for the processing of samples from histological sections, which solves the previously mentioned problems.
  • An additional objective of the present invention is to provide an automated apparatus for the processing of samples of histological sections that allows the processing of histological samples by filling a chamber where the samples are placed, by means of a mechanism of hydraulic pumps, in addition to counting with a mechanism for extracting and filtering gases from the chamber.
  • An additional objective of the present invention is to provide an automated apparatus for the processing of histological section samples that has a structure for the placement of sample cassettes, also allowing the processing of these by pouring reagent liquids and the implementation of a mechanism for the extraction and filtering of gases from the sample chamber.
  • Figure 1 shows a front perspective view of the automated apparatus for the processing of histological section samples.
  • Figure 2 shows a rear perspective view of the automated apparatus for processing histological section samples, with the lid open.
  • Figure 3 shows a rear perspective view of the automated apparatus for the processing of histological section samples, with the lid open and showing the transparency of the casing.
  • Figure 4 shows a rear perspective view of the automated apparatus for the processing of histological section samples, with the transparency of the casing.
  • Figure 5 shows a front view of the automated apparatus for the processing of histological section samples.
  • Figure 6 shows a front perspective view of the automated apparatus for the processing of histological section samples.
  • Figure 7 shows a front perspective view of the automated apparatus for the processing of samples of histological sections, where the chamber and the structure are exploded.
  • Figure 8 shows a rear perspective view of the exploded parts of the automated apparatus for the processing of histological section samples.
  • Figure 9 shows a frontal perspective view of the automated apparatus for the processing of histological section samples, where the shows the exploded view of the chamber connected to the hydraulic pumps and the structure.
  • the automated apparatus for the processing of histological section samples is made up of a casing (1) with a prismatic shape, preferably rectangular, which is hollow and does not have one of its faces, preferably the posterior one; on which is placed, a cover (2) that is attached to the casing (1) by at least one means of articulation (3) which can be a hinge, bolt, hinge and/or a combination of the above.
  • the casing (1) has an opening (4) on the front face and a section on the upper face, on which a camera (5) is placed, which is preferably made of a translucent material and has two perforations (6). , one on each side face, placed one at the top and one at the bottom.
  • a removable cover (7) which is preferably made of a translucent material, is placed on top of the chamber (5), a hole (8) is placed on the surface of the cover (7), preferably in the central part. .
  • a structure (9) with a prismatic shape, preferably rectangular, that has multiple shelves (10) is housed in the chamber (5); said shelves have slots, which allow to place various cassettes (not illustrated) containing the samples of the histological sections that are processed by means of the automated apparatus for the processing of samples of histological sections.
  • the structure (9) has a protrusion (11) at each of its corners, which allows it to be attached to the interior of the chamber (5) and not move at any time.
  • a handle (12) is placed on top of the structure (9), this configuration makes it possible to easily insert and remove said structure from the chamber (5).
  • An air suction mechanism (13) is placed outside the casing (1), preferably on the upper face.
  • a first duct (14) comes out of said suction mechanism and connects to the hole (8) in the cover. (7), this configuration allows the extraction of the gases generated in the processing of histological section samples inside the chamber (5).
  • the air suction mechanism (13) has a second duct (15) which is connected to a filtering mechanism (16) that is located outside the casing (1), preferably on one of the side faces, said mechanism filter (16) is configured to filter the gases extracted from the chamber (5), to be expelled without representing a health risk.
  • At least one support (17) is placed on the inner base of the casing (1), said supports can be cavities, as can be seen in figure 8, each support (17) is configured to support a container (18) , which is preferably cylindrical and is configured to store the reagents that are used for the processing of samples in histological sections that are carried out inside the chamber (5);
  • Each container has on its upper surface, a perforation (19) in which some tubes (20) are connected, which in turn are connected to solenoid valves (21) that are inside the casing (1) placed on a bracket ( 22) placed behind the camera (5) .
  • the solenoid valves (21) are connected by means of a pipe (23) to two hydraulic pumps (24) that are inside the casing (1), preferably one on each side of the the opening (4) where the camera (5) is located; a tube (25) is connected from each hydraulic pump (24) to each perforation (6) of the side faces of the chamber (5), this configuration allows the reagents used for the processing of samples in histological sections stored in the containers (18) inside the chamber (5).
  • This configuration allows the operation of the solenoid valves (21) and the hydraulic pumps (24) of the automated apparatus for the processing of histological section samples to be initiated through the screen (26), as well as allowing the operation parameters to be viewed.
  • a main switch (not shown) connected to the control module to power the electronic components of the control module (not shown), the screen (26), said main switch (not shown) is placed on the outer surface of the casing (1) .
  • the control module (not shown) is made up of a microcontroller (not shown), a power supply (not shown) and a wireless communication card (not shown).
  • the power source can be rechargeable batteries, disposable batteries, an alternating current cable or a combination of the above, and is configured so that once the main switch (not shown) is activated, it energizes the microcontroller (not shown). illustrated) , the screen (26) , the solenoid valves (21) , the pumps hydraulics (24), the air suction mechanism (13) and the filtering mechanism (16).
  • the wireless communication card (not illustrated) is a means of Bluetooth, WiFi (Wireless Fidelity) or UWB (Ultra Wide Band) or a combination thereof;
  • the wireless communication card is configured to remotely control the automated histology section sample processing apparatus via a smart device such as a laptop, tablet and/or mobile phone.
  • Example 1 Processing of samples of histological sections by means of the automated apparatus for the processing of samples of histological sections, subject of the present invention.
  • the chamber (5) is removed from the casing (1) to subsequently extract the structure (9) to place the cassettes containing the samples of histological sections in the slots of the shelves (10); Subsequently, the structure (9) is inserted into the chamber (5), which is positioned in the opening (4). Subsequently, the general switch (not illustrated) is activated to energize the screen (26) and the control module (not illustrated); Through the screen or an intelligent device, the operating parameters of the control module (not illustrated) are programmed, so that the hydraulic pumps (24) and the electrovalves (21) are activated, which control the reagents that are used. for the processing of samples in histological sections stored in the containers (18) inside the chamber (5).
  • the air suction mechanism (13) is activated to extract the gases generated inside the chamber (5); to send them to the filtering mechanism (16) that is located outside the casing (1), and thus filter the gases extracted from the chamber (5), to be expelled without representing a health risk.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention discloses an automated apparatus for processing histological section samples that allows the histological samples to be processed by filling a chamber, in which the samples are placed, with reagents using a hydraulic pump mechanism, the apparatus also comprising a mechanism for extracting and filtering gases in the chamber. The automated apparatus for processing histological section samples comprises a structure for the placement of sample cassettes, further allowing these samples to be processed by the pouring of liquid reagents and the use of a mechanism for extracting and filtering gases in the sample chamber.

Description

APARATO AUTOMATIZADO PARA EL PROCESAMIENTO DE MUESTRAS DE CORTES HISTOLÓGICOS AUTOMATED APPARATUS FOR PROCESSING SAMPLES OF HISTOLOGICAL SECTIONS
CAMPO TÉCNICO DE LA INVENCIÓN TECHNICAL FIELD OF THE INVENTION
La presente invención se relaciona con el campo técnico de la mecánica, electrónica, biología, anatomía, medicina, inmunología, patología, fisiología, citología, nutrición, bioquímica, genética y más especí ficamente con la histología, ya que aporta un aparato automati zado para el procesamiento de muestras de cortes histológicos . The present invention is related to the technical field of mechanics, electronics, biology, anatomy, medicine, immunology, pathology, physiology, cytology, nutrition, biochemistry, genetics and more specifically with histology, since it provides an automated apparatus for the processing of histological section samples.
ANTECEDENTES DE LA INVENCIÓN BACKGROUND OF THE INVENTION
La histología es una rama de la biología que estudia los tej idos orgánicos de animales y vegetales en sus aspectos microscópicos : características , composición, estructura y función . Por ello , tiene como herramienta fundamental el microscopio . Histology is a branch of biology that studies the organic tissues of animals and plants in their microscopic aspects: characteristics, composition, structure and function. For this reason , his fundamental tool is the microscope .
La palabra histología proviene del griego histós que signi fica ' tej ido ' , 'poste ' o 'vara' ( en el sentido de " estar de pie" ) ; incluye el sufij o logia, que signi fica ' estudio o ciencia' . Por lo tanto , la histología estudia las estructuras mínimas que conforman los organismos de los seres vivos . The word histology comes from the Greek histós which means 'fabric', 'post' or 'rod' (in the sense of "to stand"); includes the suffix or logia, which means 'study or science'. Therefore, histology studies the minimal structures that make up the organisms of living beings.
Las aplicaciones de la histología abarcan ciencias relacionadas y campos tan diversos como la anatomía, la medicina, la inmunología, la patología, la fisiología, la citología, la nutrición, la bioquímica, la genética, la investigación forense , la agricultura y la arqueología, entre otros . La histología vegetal se ocupa del análisis las plantas, es decir, los seres vivos que pertenecen al reino vegetal. La histología vegetal comprende el estudio de dos tejidos fundamentales : The applications of histology span related sciences and fields as diverse as anatomy, medicine, immunology, pathology, physiology, cytology, nutrition, biochemistry, genetics, forensics, agriculture, and archaeology, among others . Plant histology deals with the analysis of plants, that is, living beings that belong to the plant kingdom. Plant histology includes the study of two fundamental tissues:
- Tejidos meris temáticos (tejidos de crecimiento) , los cuales incluyen tejidos primarios y secundarios; y,- Meristhematic tissues (growth tissues), which include primary and secondary tissues; and,
- Tejidos adultos, que incluyen los tejidos parenquimatosos , de soporte, protectores, secretores y conductores . - Adult tissues, which include parenchymal, supportive, protective, secretory, and conductive tissues.
La histología animal estudia los metazoos, es decir, los seres vivos animales. Animal histology studies metazoans, that is, living animal beings.
La histología humana está incluida en la histología de los animales, ya que desde el punto de vista biológico los seres humanos forman parte del reino animal. Sin embargo, constituye un área específica de interés en lo que a salud se refiere. Human histology is included in animal histology, since from the biological point of view human beings are part of the animal kingdom. However, it constitutes a specific area of interest as far as health is concerned.
La histología animal comprende el estudio de los siguientes te j idos : Animal histology includes the study of the following tissues:
- tejido conjuntivo o conectivo, que reúne las variedades de tejido cartilaginoso, tejido óseo, tejido adiposo y sangre ; - connective or connective tissue, which includes the varieties of cartilaginous tissue, bone tissue, adipose tissue and blood;
- tejido epitelial, que es el tejido que recubre las superficies del organismo; - epithelial tissue, which is the tissue that covers the surfaces of the organism;
- tejido muscular, formado por células que usan energía química para generar el movimiento; - muscle tissue, made up of cells that use chemical energy to generate movement;
- tejido nervioso, que se refiere a las neuronas que transmiten la información útil para el organismo. - Nervous tissue, which refers to the neurons that transmit useful information to the organism.
El proceso histológico se refiere a las técnicas de la histología necesarias para estudiar los tejidos. Se basa en una serie de pasos elementales. 1. Introducción, en la cual tiene lugar la obtención del tejido (por ejemplo, mediante una biopsia) . The histological process refers to the histology techniques necessary to study tissues. It is based on a series of elementary steps. 1. Introduction, in which tissue harvesting (eg, by biopsy) takes place.
2. Fijación, proceso que pretende preservar las características del tejido mediante técnicas diversas. 2. Fixation, a process that aims to preserve the characteristics of the tissue through various techniques.
3. Inclusión, método para endurecer el tejido a fin de facilitar los cortes para el estudio por secciones.3. Embedding, method of stiffening tissue to facilitate cuts for sectional study.
4. Corte, se refiere al proceso de corte de los tejidos endurecidos, los cuales se ejecutan con la ayuda de un artefacto denominado microtome. 4. Cutting, refers to the process of cutting hardened tissues, which are carried out with the help of an artifact called a microtome.
5. Tinción: es un proceso que aumenta el contraste por medio de la coloración, ya que a la vista del microscopio, muchos tejidos son incoloros. 5. Staining: it is a process that increases the contrast through staining, since many tissues are colorless under the microscope.
6. Observación: se refiere al proceso de observación y análisis realizado por el especialista a través del microscopio, a partir del cual es posible arrojar conclusiones . 6. Observation: refers to the process of observation and analysis carried out by the specialist through the microscope, from which it is possible to draw conclusions.
La histología es de vital importancia para conocer el funcionamiento de los organismos vivos, lo que tiene repercusiones en la investigación médica y científica en general e, incluso, en la economía. Histology is of vital importance to understand the functioning of living organisms, which has repercussions for medical and scientific research in general, and even for the economy.
Derivado a la creciente importancia en el campo del procesamiento de muestras histológicas, con el tiempo se han desarrollado diversos aparato automatizado para el procesamiento de muestras de cortes histológicos, motivo por el cual se realizó una búsqueda del estado de la técnica al respecto, y se encontró la patente Estados Unidos número US9079735 (B2) , con fecha de publicación del 14 de julio de 2015, que tiene como título "MÉTODO Y ALIMENTADOR DE MUESTRAS HISTOLÓGICAS ANTIADHERENTES" que describe un aparato y método para alimentar portaobjetos de muestras de histología desde una pila de portaobjetos en una impresora de portaobjetos. La pila de portaobjetos incluye un primer portaobjetos, el siguiente que se quitará y un segundo portaobj etos que tienen superficies adyacentes . Se aplica un fluj o de gas a una ubicación en la que se encuentran las superficies adyacentes del primer y segundo portaobj etos cuando se retira el primer portaobj etos de la pila . El fluj o de gas , que puede ser un chorro o ráfaga de aire aplicado a través de una boquilla, y que puede aplicarse antes y/o durante la extracción del portaobj etos de la pila, ayuda a despegar los portaobj etos para mej orar la acción de alimentación . Derived from the growing importance in the field of histological sample processing, over time various automated devices have been developed for the processing of samples of histological sections, which is why a search for the state of the art in this regard was carried out, and United States patent number US9079735 (B2) was found, with a publication date of July 14, 2015, entitled "NON-STICK HISTOLOGICAL SAMPLE FEEDER AND METHOD" that describes an apparatus and method for feeding histology sample slides from a stack of slides in a slide printer. The slide stack includes a first slide, the next to be removed and a second slide having adjacent surfaces. A flow of gas is applied to a location where the adjacent surfaces of the first and second slides meet when the first slide is removed from the stack. The flow of gas, which can be a jet or blast of air applied through a nozzle, and which can be applied before and/or during removal of the slide from the stack, helps to detach the slides to improve the feeding action.
También se encontró la patente de Estados Unidos número US US 8715594 (B2 ) , con fecha de publicación del 06 de mayo de 2014 , que tiene como titulo "APARATO PARA INCLUIR MUESTRAS DE TEJIDO" que describe un aparato de inclusión de tej ido de histología que tiene una salida para el medio de inclusión y un área de trabaj o generalmente hori zontal debaj o de la salida para soportar un casete . El área de trabaj o incluye una superficie de recorte generalmente hori zontal que tiene ondulaciones y que está sustancialmente nivelada con el resto del área de trabaj o . The United States patent number US US 8715594 (B2) was also found, with a publication date of May 6, 2014, which has the title "APPARATO TO INCLUDE TISSUE SAMPLES" that describes a histology tissue inclusion apparatus. having an outlet for embedding medium and a generally horizontal work area below the outlet to support a cassette. The work area includes a generally horizontal trim surface that is corrugated and is substantially level with the remainder of the work area.
Como se puede observar, ninguno de los documentos evidencia un aparato que permite el procesamiento de muestras histológicas mediante el llenado de una cámara donde se colocan las muestras , mediante un mecanismo de bombas hidráulicas , además de contar con un mecanismo de extracción y filtrado de gases de la cámara . As can be seen, none of the documents show an apparatus that allows the processing of histological samples by filling a chamber where the samples are placed, through a mechanism of hydraulic pumps, in addition to having a gas extraction and filtering mechanism. of the camera .
Tampoco hay evidencia de que los aparatos cuentan con una estructura para la colocación de casets de muestras , permitiendo también el procesado de estas mediante le vertimiento de líquidos reactivos y de la implantación de un mecanismo de extracción y filtrado de gases de la cámara de las muestras . OBJETO DE LA INVENCIÓN There is also no evidence that the devices have a structure for the placement of sample cassettes, also allowing the processing of these by pouring reagent liquids and the implementation of a mechanism for extracting and filtering gases from the sample chamber. . OBJECT OF THE INVENTION
La presente invención, tiene como obj etivo proporcionar un aparato automati zado para el procesamiento de muestras de cortes histológicos , que resuelve los problemas anteriormente mencionados . The objective of the present invention is to provide an automated apparatus for the processing of samples from histological sections, which solves the previously mentioned problems.
Un obj etivo adicional de la presente invención es proporcionar un aparato automati zado para el procesamiento de muestras de cortes histológicos que permite el procesamiento de muestras histológicas mediante el llenado una cámara donde se colocan las muestras , mediante un mecanismo de bombas hidráulicas , además de contar con un mecanismo de extracción y filtrado de gases de la cámara . An additional objective of the present invention is to provide an automated apparatus for the processing of samples of histological sections that allows the processing of histological samples by filling a chamber where the samples are placed, by means of a mechanism of hydraulic pumps, in addition to counting with a mechanism for extracting and filtering gases from the chamber.
Un obj etivo adicional de la presente invención es proporcionar un aparato automati zado para el procesamiento de muestras de cortes histológicos que cuenta con una estructura para la colocación de casets de muestras , permitiendo también el procesado de estas mediante le vertimiento de líquidos reactivos y de la implantación de un mecanismo de extracción y filtrado de gases de la cámara de las muestras . An additional objective of the present invention is to provide an automated apparatus for the processing of histological section samples that has a structure for the placement of sample cassettes, also allowing the processing of these by pouring reagent liquids and the implementation of a mechanism for the extraction and filtering of gases from the sample chamber.
BREVE DESCRIPCIÓN DE LAS FIGURAS BRIEF DESCRIPTION OF THE FIGURES
Los detalles característicos de este novedoso aparato automati zado para el procesamiento de muestras de cortes histológicos se muestran claramente en la siguiente descripción y en las figuras que se acompañan, asi como una ilustración de aquella, y siguiendo los mismos signos de referencia para indicar las partes mostradas . Sin embargo , dichas figuras se muestran a manera de ej emplo y no deben de ser consideradas como limitativas para la presente invención . La figura 1 muestra una vista en perspectiva frontal del aparato automati zado para el procesamiento de muestras de cortes histológicos . The characteristic details of this novel automated apparatus for the processing of histological section samples are clearly shown in the following description and in the accompanying figures, as well as an illustration thereof, and following the same reference signs to indicate the parts displayed . However , said figures are shown by way of example and should not be considered as limiting for the present invention . Figure 1 shows a front perspective view of the automated apparatus for the processing of histological section samples.
La figura 2 muestra una vista en perspectiva posterior del aparato automati zado para el procesamiento de muestras de cortes histológicos , con la tapa abierta . Figure 2 shows a rear perspective view of the automated apparatus for processing histological section samples, with the lid open.
La figura 3 muestra una vista en perspectiva posterior del aparato automati zado para el procesamiento de muestras de cortes histológicos , con la tapa abierta y mostrando la transparencia de la carcasa . Figure 3 shows a rear perspective view of the automated apparatus for the processing of histological section samples, with the lid open and showing the transparency of the casing.
La figura 4 muestra una vista en perspectiva posterior del aparato automati zado para el procesamiento de muestras de cortes histológicos , con la transparencia de la carcasa . Figure 4 shows a rear perspective view of the automated apparatus for the processing of histological section samples, with the transparency of the casing.
La figura 5 muestra una vista frontal del aparato automati zado para el procesamiento de muestras de cortes histológicos . Figure 5 shows a front view of the automated apparatus for the processing of histological section samples.
La figura 6 muestra una vista en perspectiva frontal del aparato automati zado para el procesamiento de muestras de cortes histológicos . Figure 6 shows a front perspective view of the automated apparatus for the processing of histological section samples.
La figura 7 muestra una vista en perspectiva frontal del aparato automati zado para el procesamiento de muestras de cortes histológicos , donde se muestra el despiece de la cámara y la estructura .Figure 7 shows a front perspective view of the automated apparatus for the processing of samples of histological sections, where the chamber and the structure are exploded.
La figura 8 muestra una vista en perspectiva posterior de la explosión de partes del aparato automati zado para el procesamiento de muestras de cortes histológicos . Figure 8 shows a rear perspective view of the exploded parts of the automated apparatus for the processing of histological section samples.
La figura 9 muestra una vista en perspectiva frontal del aparato automati zado para el procesamiento de muestras de cortes histológicos , donde se muestra el despiece de la cámara conectada a las bombas hidráulicas y la estructura . Figure 9 shows a frontal perspective view of the automated apparatus for the processing of histological section samples, where the shows the exploded view of the chamber connected to the hydraulic pumps and the structure.
DESCRIPCIÓN DETALLADA DE LA INVENCIÓN DETAILED DESCRIPTION OF THE INVENTION
Para una mej or comprensión de la invención, a continuación, se enlistan las partes que componen el aparato automati zado para el procesamiento de muestras de cortes histológicos : For a better understanding of the invention, the parts that make up the automated apparatus for the processing of histological section samples are listed below:
I . Carcasa YO . Case
2 . Tapa 2 . Top
3 . Medio de articulación 3 . means of articulation
4 . Abertura 4 . Opening
5 . Cámara 5 . Camera
6 . Perforación 6 . Drilling
7 . Cubierta 7 . Deck
8 . Ori ficio 8 . hole
9 . Estructura 9 . Structure
10 . Estantes 10 . shelves
I I . Saliente I I . Outgoing
12 . Agarradera 12 . Handle
13 . Mecanismo de succión de aire 13 . Air suction mechanism
14 . Primer ducto 14 . first pipeline
15 . Segundo ducto fifteen . Second pipeline
16 . Mecanismo de filtrado 16 . filter mechanism
17 . Soporte 17 . Medium
18 . Contenedor 18 . Container
19 . Perforación 19 . Drilling
20 . Tubos twenty . tubes
21 . Electroválvulas twenty-one . solenoid valves
22 . Ménsula 22 . Bracket
23 . Tubería 23 . Pipeline
24 . Bombas hidráulicas 24 . Hydraulic bombs
25 . Tubo 26. Pantalla 25 . Tube 26. Screen
Con referencia a las figuras, el aparato automatizado para el procesamiento de muestras de cortes histológicos está conformado por una carcasa (1) de forma prismática, preferentemente rectangular, la cual es hueca y no cuenta con una de sus caras, preferentemente la posterior; sobre la cual se coloca, una tapa (2) que se une a la carcasa (1) por, al menos, un medio de articulación (3) el cual puede ser bisagra, pernio, gozne y/o la combinación de los anteriores. With reference to the figures, the automated apparatus for the processing of histological section samples is made up of a casing (1) with a prismatic shape, preferably rectangular, which is hollow and does not have one of its faces, preferably the posterior one; on which is placed, a cover (2) that is attached to the casing (1) by at least one means of articulation (3) which can be a hinge, bolt, hinge and/or a combination of the above.
La carcas (1) cuenta con una abertura (4) en la cara frontal y una sección de la cara superior, sobre la cual se coloca una cámara (5) la cual preferentemente es de un material traslúcido y cuenta con dos perforaciones (6) , una en cada cara lateral, colocada una en la parte superior y otra en la parte inferior. Una cubierta (7) removible, la cual preferentemente es de un material traslúcido se coloca en la parte superior de la cámara (5) , un orificio (8) se coloca en la superficie de la cubierta (7) , preferentemente en la parte central . The casing (1) has an opening (4) on the front face and a section on the upper face, on which a camera (5) is placed, which is preferably made of a translucent material and has two perforations (6). , one on each side face, placed one at the top and one at the bottom. A removable cover (7), which is preferably made of a translucent material, is placed on top of the chamber (5), a hole (8) is placed on the surface of the cover (7), preferably in the central part. .
Una estructura (9) de forma prismática, preferentemente rectangular, que cuenta con múltiples estantes (10) se alberga en la cámara (5) ; dichos estantes tienen ranuras, lo que permite colocar diversos casetes (no ilustrados) que contienen las muestras de los cortes histológicos que son procesadas por medio del aparato automatizado para el procesamiento de muestras de cortes histológicos. La estructura (9) cuenta con una saliente (11) en cada una de sus esquinas, lo que permite fijarse al interior de la cámara (5) y que no tenga movimiento en ningún momento. Una agarradera (12) se coloca en la parte superior de la estructura (9) , esta configuración permite introducir y sacar con facilidad dicha estructura de la cámara (5) . A structure (9) with a prismatic shape, preferably rectangular, that has multiple shelves (10) is housed in the chamber (5); said shelves have slots, which allow to place various cassettes (not illustrated) containing the samples of the histological sections that are processed by means of the automated apparatus for the processing of samples of histological sections. The structure (9) has a protrusion (11) at each of its corners, which allows it to be attached to the interior of the chamber (5) and not move at any time. A handle (12) is placed on top of the structure (9), this configuration makes it possible to easily insert and remove said structure from the chamber (5).
Un mecanismo de succión de aire (13) se coloca al exterior de la carcasa (1) , preferentemente en la cara superior, de dicho mecanismo de succión sale un primer ducto (14) que se conecta en el orificio (8) de la cubierta (7) , esta configuración permite la extracción de los gases generados en el procesamiento de las muestras de cortes histológicas dentro de la cámara (5) . El mecanismo de succión de aire (13) tiene un segundo ducto (15) el cual se conecta a un mecanismo de filtrado (16) que se encuentra al exterior de la carcasa (1) , preferentemente en una de las caras laterales, dicho mecanismo de filtrado (16) está configurado filtrar los gases extraídos de la cámara (5) , para ser expulsados sin representar un riesgo a la salud. An air suction mechanism (13) is placed outside the casing (1), preferably on the upper face. A first duct (14) comes out of said suction mechanism and connects to the hole (8) in the cover. (7), this configuration allows the extraction of the gases generated in the processing of histological section samples inside the chamber (5). The air suction mechanism (13) has a second duct (15) which is connected to a filtering mechanism (16) that is located outside the casing (1), preferably on one of the side faces, said mechanism filter (16) is configured to filter the gases extracted from the chamber (5), to be expelled without representing a health risk.
Al menos, un soporte (17) se coloca en la base interior de la carcasa (1) , dichos soportes pueden son cavidades, tal como se aprecia en la figura 8, cada soporte (17) está configurado para sustentar un contenedor (18) , el cual preferentemente es cilindrico y está configurado para almacenar los reactivos que se utilizan para el procesamiento de muestras en cortes histológicos que se realiza dentro de la cámara (5) ; cada contenedor tiene en su superficie superior, una perforación (19) en la cual se conectan unos tubos (20) que a su vez están conectados a unas electroválvulas (21) que se encuentran dentro de la carcasa (1) colocadas sobre una ménsula (22) colocada detrás de la cámara (5) . At least one support (17) is placed on the inner base of the casing (1), said supports can be cavities, as can be seen in figure 8, each support (17) is configured to support a container (18) , which is preferably cylindrical and is configured to store the reagents that are used for the processing of samples in histological sections that are carried out inside the chamber (5); Each container has on its upper surface, a perforation (19) in which some tubes (20) are connected, which in turn are connected to solenoid valves (21) that are inside the casing (1) placed on a bracket ( 22) placed behind the camera (5) .
Las electroválvulas (21) están conectadas por medio de una tubería (23) a, dos bombas hidráulicas (24) que se encuentran dentro de la carcasa (1) , preferentemente una a cada lado de la abertura (4) donde se encuentra la cámara (5) ; un tubo (25) se conecta desde cada bomba hidráulica (24) a cada perforación (6) de las caras laterales de la cámara (5) , esta configuración permite mandar los reactivos que se utilizan para el procesamiento de muestras en cortes histológicos almacenados en los contenedores (18) dentro de la cámara (5) . The solenoid valves (21) are connected by means of a pipe (23) to two hydraulic pumps (24) that are inside the casing (1), preferably one on each side of the the opening (4) where the camera (5) is located; a tube (25) is connected from each hydraulic pump (24) to each perforation (6) of the side faces of the chamber (5), this configuration allows the reagents used for the processing of samples in histological sections stored in the containers (18) inside the chamber (5).
Una pantalla (26) que preferentemente es táctil, se coloca en al exterior de la carcasa (1) , preferentemente en la cara frontal y está conectada a un módulo de control (no ilustrado) que está dentro de la carcasa (1) ; esta configuración permite que por medio de la pantalla (26) se inicie la operación de las electroválvulas (21) y las bombas hidráulicas (24) del aparato automatizado para el procesamiento de muestras de cortes histológicos, asi como permitir visualizar los parámetros de operación. Adicionalmente, se tiene un interruptor general (no ilustrado) conectado al módulo de control para energizar los componentes electrónicos del módulo de control (no ilustrado) , la pantalla (26) , dicho interruptor general (no ilustrado) se coloca en la superficie exterior de la carcasa (1) . A screen (26) that is preferably tactile, is placed outside the casing (1), preferably on the front face, and is connected to a control module (not illustrated) that is inside the casing (1); This configuration allows the operation of the solenoid valves (21) and the hydraulic pumps (24) of the automated apparatus for the processing of histological section samples to be initiated through the screen (26), as well as allowing the operation parameters to be viewed. Additionally, there is a main switch (not shown) connected to the control module to power the electronic components of the control module (not shown), the screen (26), said main switch (not shown) is placed on the outer surface of the casing (1) .
El módulo de control (no ilustrado) está conformado por un microcontrolador (no ilustrado) , una fuente de alimentación (no ilustrada) y una tarjeta de comunicación inalámbrica (no ilustrada) . The control module (not shown) is made up of a microcontroller (not shown), a power supply (not shown) and a wireless communication card (not shown).
La fuente de alimentación (no ilustrada) puede ser baterías recargables, baterías desechables, un cable de corriente alterna o la combinación de las anteriores, y está configurada para una vez que el interruptor general (no ilustrado) es accionado, energizar el microcontrolador (no ilustrado) , la pantalla (26) , las electroválvulas (21) , las bombas hidráulicas (24) , el mecanismo de succión de aire (13) y el mecanismo de filtrado (16) . The power source (not shown) can be rechargeable batteries, disposable batteries, an alternating current cable or a combination of the above, and is configured so that once the main switch (not shown) is activated, it energizes the microcontroller (not shown). illustrated) , the screen (26) , the solenoid valves (21) , the pumps hydraulics (24), the air suction mechanism (13) and the filtering mechanism (16).
La tarjeta de comunicación inalámbrica (no ilustrada) es un medio de Bluetooth, WiFi (Wireless Fidelity por sus siglas en inglés) o UWB (Ultra Wide Band por sus siglas en inglés) o la combinación de las anteriores; la tarjeta de comunicación inalámbrica está configurada para controlar via remota el aparato automatizado para el procesamiento de muestras de cortes histológicos por medio de un dispositivo inteligente, como puede ser una computadora portátil, una tableta y/o un teléfono móvil. The wireless communication card (not illustrated) is a means of Bluetooth, WiFi (Wireless Fidelity) or UWB (Ultra Wide Band) or a combination thereof; The wireless communication card is configured to remotely control the automated histology section sample processing apparatus via a smart device such as a laptop, tablet and/or mobile phone.
REALIZACIÓN PREFERENTE DE LA INVENCIÓN PREFERRED EMBODIMENT OF THE INVENTION
Ejemplos examples
Los siguientes ejemplos ilustran una manera preferente, de cómo llevar a cabo la realización de la presente invención, por lo que no deben ser considerados como limitativos de la misma . The following examples illustrate a preferred way of how to carry out the implementation of the present invention, so they should not be considered as limiting the same.
Ejemplo 1. Procesamiento de muestras de cortes histológicos por medio del aparato automatizado para el procesamiento de muestras de cortes histológicos, motivo de la presente invención. Example 1. Processing of samples of histological sections by means of the automated apparatus for the processing of samples of histological sections, subject of the present invention.
Se retira la cámara (5) de la carcas (1) para posteriormente extraer la estructura (9) para colocar los casetes que contienen las muestras de cortes histológicos en las ranuras de los estantes (10) ; posteriormente se ingresa la estructura (9) dentro de la cámara (5) , la cual se posiciona en la abertura ( 4 ) . Posteriormente se acciona el interruptor general (no ilustrado) , para energizar la pantalla (26) y el módulo de control (no ilustrado) ; por medio de la pantalla o de un dispositivo inteligente se programan los parámetros de operación del módulo de control (no ilustrado) , para que se accionen las bombas hidráulicas (24) y las electroválvulas (21) , las cuales mandan los reactivos que se utilizan para el procesamiento de muestras en cortes histológicos almacenados en los contenedores (18) dentro de la cámara (5) . The chamber (5) is removed from the casing (1) to subsequently extract the structure (9) to place the cassettes containing the samples of histological sections in the slots of the shelves (10); Subsequently, the structure (9) is inserted into the chamber (5), which is positioned in the opening (4). Subsequently, the general switch (not illustrated) is activated to energize the screen (26) and the control module (not illustrated); Through the screen or an intelligent device, the operating parameters of the control module (not illustrated) are programmed, so that the hydraulic pumps (24) and the electrovalves (21) are activated, which control the reagents that are used. for the processing of samples in histological sections stored in the containers (18) inside the chamber (5).
Una vez finalizado el procesamiento de las muestras en cortes histológicos, se acciona el mecanismo de succión de aire (13) para extraer los gases generados dentro de la cámara (5) ; para enviarlos al mecanismo de filtrado (16) que se encuentra al exterior de la carcasa (1) , y asi filtrar los gases extraídos de la cámara (5) , para ser expulsados sin representar un riesgo a la salud. Once the processing of the samples in histological sections is finished, the air suction mechanism (13) is activated to extract the gases generated inside the chamber (5); to send them to the filtering mechanism (16) that is located outside the casing (1), and thus filter the gases extracted from the chamber (5), to be expelled without representing a health risk.
El invento ha sido descrito suficientemente como para que una persona con conocimientos medios en la materia pueda reproducir y obtener los resultados que mencionamos en la presente invención. Sin embargo, cualquier persona hábil en el campo de la técnica que compete el presente invento puede ser capaz de hacer modificaciones no descritas en la presente solicitud, sin embargo, si para la aplicación de estas modificaciones en una estructura determinada o en el proceso de manufactura de este, se requiere de la materia reclamada en las siguientes reivindicaciones, dichas estructuras deberán ser comprendidas dentro del alcance de la invención. The invention has been sufficiently described so that a person with average knowledge in the matter can reproduce and obtain the results that we mention in the present invention. However, any person skilled in the field of the technique that the present invention is competent may be able to make modifications not described in the present application, however, if for the application of these modifications in a determined structure or in the manufacturing process of this, the matter claimed in the following claims is required, said structures must be understood within the scope of the invention.

Claims

REIVINDICACIONES
1. Un aparato automatizado para el procesamiento de muestras de cortes histológicos, caracterizado porque comprende: una carcasa (1) de forma prismática, preferentemente rectangular, la cual es hueca y no cuenta con una de sus caras, sobre la cual se coloca, una tapa (2) que se une a la carcasa (1) por, al menos, un medio de articulación (3) ; la carcas (1) cuenta con una abertura (4) en la cara frontal y una sección de la cara superior, sobre la cual se coloca una cámara (5) la cual preferentemente es de un material traslúcido y cuenta con dos perforaciones (6) ; una cubierta (7) se coloca en la parte superior de la cámara (5) , un orificio (8) se coloca en la superficie de la cubierta (7) ; una estructura (9) que cuenta con múltiples estantes (10) se alberga en la cámara (5) , dichos estantes tienen ranuras; una saliente (11) se coloca en cada esquina de la estructura (9) ; un mecanismo de succión de aire (13) se coloca al exterior de la carcasa (1) , de dicho mecanismo de succión sale un primer ducto (14) que se conecta en el orificio (8) de la cubierta (7) ; el mecanismo de succión de aire (13) tiene un segundo ducto (15) el cual se conecta a un mecanismo de filtrado (16) que se encuentra al exterior de la carcasa (1) ; al menos, un soporte (17) se coloca en la base interior de la carcasa (1) ; un contenedor (18) se coloca sobre cada soporte (17) , cada contenedor tiene en su superficie superior, una perforación (19) en la cual se conectan unos tubos (20) que a su vez están conectados a unas electroválvulas (21) que se encuentran dentro de la carcasa (1) colocadas sobre una ménsula (22) colocada detrás de la cámara (5) ; las electroválvulas (21) están conectadas por medio de una tubería (23) a, dos bombas hidráulicas (24) que se encuentran dentro de la carcasa (1) ; un tubo (25) se conecta desde cada bomba hidráulica (24) a cada perforación (6) de las caras laterales de la cámara (5) ; una pantalla (26) se coloca en al exterior de la carcasa (1) y está conectada a un módulo de control que está dentro de la carcasa (1) ; y, un interruptor general se coloca en la superficie exterior de la carcasa (1) y se conecta al módulo de control. 1. An automated apparatus for the processing of samples from histological sections, characterized in that it comprises: a casing (1) with a prismatic shape, preferably rectangular, which is hollow and does not have one of its faces, on which it is placed, a cover (2) that is attached to the casing (1) by at least one means of articulation (3); The casing (1) has an opening (4) on the front face and a section on the upper face, on which a camera (5) is placed, which is preferably made of a translucent material and has two perforations (6). ; a cover (7) is placed on the top of the chamber (5), a hole (8) is placed on the surface of the cover (7); a structure (9) that has multiple shelves (10) is housed in the chamber (5), said shelves have slots; a protrusion (11) is placed at each corner of the structure (9); an air suction mechanism (13) is placed outside the casing (1), from said suction mechanism comes a first duct (14) that connects to the hole (8) of the cover (7); the air suction mechanism (13) has a second duct (15) which is connected to a filtering mechanism (16) that is outside the casing (1); at least one support (17) is placed on the inner base of the casing (1); a container (18) is placed on each support (17), each container has on its upper surface, a perforation (19) in which tubes (20) are connected, which in turn are connected to electrovalves (21) that They are inside the casing (1) placed on a bracket (22) placed behind the camera (5); the solenoid valves (21) are connected by means of a pipe (23) to two hydraulic pumps (24) that are inside the casing (1); a tube (25) is connected from each hydraulic pump (24) to each perforation (6) of the side faces of the chamber (5); a screen (26) is placed outside the casing (1) and is connected to a control module that is inside the casing (1); and, a general switch is placed on the outer surface of the casing (1) and is connected to the control module.
2. El aparato de la reivindicación 1 caracterizado porque, la carcasa (1) y la estructura (9) tienen forma prismática. 2. The apparatus of claim 1 characterized in that the casing (1) and the structure (9) have a prismatic shape.
3. El aparato de la reivindicación anterior caracterizado porque, la forma prismática es rectangular. 3. The apparatus of the preceding claim, characterized in that the prismatic shape is rectangular.
4. El aparato de la reivindicación 1 caracterizado porque, la cara faltante de la carcasa (1) es la posterior. 4. The apparatus of claim 1 characterized in that the missing face of the casing (1) is the rear.
5. El aparato de la reivindicación 1 caracterizado porque, los medios de articulación (3) son una bisagra, pernio, gozne y/o la combinación de los anteriores. 5. The apparatus of claim 1 characterized in that the articulation means (3) are a hinge, bolt, hinge and/or a combination of the above.
6. El aparato de la reivindicación 1 caracterizado porque, las perforaciones (6) , se colocan en cada cara lateral de la cámara (5) . 6. The apparatus of claim 1 characterized in that the perforations (6) are placed on each side face of the chamber (5).
7. El aparato de la reivindicación anterior caracterizado porque, las perforaciones (6) se coloca una en la parte superior y otra en la parte inferior. 7. The apparatus of the preceding claim, characterized in that the perforations (6) are placed one at the top and the other at the bottom.
8. El aparato de la reivindicación 1 caracterizado porque, la cubierta (7) es removible. 8. The apparatus of claim 1 characterized in that the cover (7) is removable.
9. El aparato de la reivindicación 1 caracterizado porque, la cámara (5) y la cubierta (7) son de un material traslúcido. 9. The apparatus of claim 1 characterized in that the chamber (5) and the cover (7) are made of a translucent material.
10. El aparato de la reivindicación 1 caracterizado porque, el orificio (8) está en la parte central de la cubierta (7) . 10. The apparatus of claim 1 characterized in that the hole (8) is in the central part of the cover (7).
11. El aparato de la reivindicación 1 caracterizado porque, una agarradera (12) se coloca en la parte superior de la estructura ( 9 ) . 11. The apparatus of claim 1 characterized in that a handle (12) is placed at the top of the structure (9).
12. El aparato de la reivindicación 1 caracterizado porque, el mecanismo de succión de aire (13) se coloca en la cara superior de la carcasa (1) . 12. The apparatus of claim 1 characterized in that the air suction mechanism (13) is placed on the upper face of the casing (1).
13. El aparato de la reivindicación 1 caracterizado porque, el mecanismo de filtrado (16) que se encuentra en una de las caras laterales de la carcasa (1) . 13. The apparatus of claim 1 characterized in that the filtering mechanism (16) is located on one of the side faces of the casing (1).
14. El aparato de la reivindicación 1 caracterizado porque, los soportes (17) son cavidades. The apparatus of claim 1 characterized in that the supports (17) are cavities.
15. El aparato de la reivindicación 1 caracterizado porque, los contenedores (18) son cilindricos y están configurados para almacenar reactivos. The apparatus of claim 1 characterized in that the containers (18) are cylindrical and are configured to store reagents.
16. El aparato de la reivindicación 1 caracterizado porque, las bombas hidráulicas (24) se colocan una a cada lado de la abertura (4) donde se encuentra la cámara (5) . 16. The apparatus of claim 1 characterized in that the hydraulic pumps (24) are placed one on each side of the opening (4) where the chamber (5) is located.
17. El aparato de la reivindicación 1 caracterizado porque, la pantalla (26) es táctil. 17. The apparatus of claim 1 characterized in that the screen (26) is tactile.
18. El aparato de las reivindicaciones 1 y 17 caracterizado porque, la pantalla (26) se coloca en la cara frontal de la carcasa ( 1 ) . 18. The apparatus of claims 1 and 17 characterized in that the screen (26) is placed on the front face of the casing (1).
19. El aparato de la reivindicación 1 caracterizado porque, el módulo de control está conformado por un microcontrolador , una fuente de alimentación y una tarjeta de comunicación inalámbrica . 16 19. The apparatus of claim 1 characterized in that the control module is made up of a microcontroller, a power supply and a wireless communication card. 16
20. El aparato de las reivindicaciones 1 y 19 caracterizado porque, la fuente de alimentación es baterías recargables, baterías desechables, un cable de corriente alterna o la combinación de las anteriores. 20. The apparatus of claims 1 and 19 characterized in that the power source is rechargeable batteries, disposable batteries, an alternating current cable or a combination of the above.
21. El aparato de las reivindicaciones 1 y 19 caracterizado porque, la tarjeta de comunicación inalámbrica es un medio de Bluetooth, WiFi, UWB o la combinación de las anteriores. 21. The apparatus of claims 1 and 19, characterized in that the wireless communication card is a means of Bluetooth, WiFi, UWB or a combination of the above.
22. El aparato de las reivindicaciones 1 19 y 29 caracterizado porque, la tarjeta de comunicación se enlaza con un dispositivo inteligente. 22. The apparatus of claims 1, 19 and 29, characterized in that the communication card is linked to an intelligent device.
PCT/MX2022/050094 2021-11-11 2022-10-18 Automated apparatus for processing histological section samples WO2023085912A1 (en)

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MXMX/U/2021/000605 2021-11-11

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003029845A2 (en) * 2001-10-01 2003-04-10 Vision Biosystems Limited Histological tissue specimen treatment
US20050186114A1 (en) * 2002-04-15 2005-08-25 Kurt Reinhardt Automated high volume slide processing system
GB2432669A (en) * 2005-11-29 2007-05-30 Leica Microsystems Tissue processor adaptable to different reagent containers
WO2010048631A2 (en) * 2008-10-24 2010-04-29 Biomicro, Inc. Modular system for performing laboratory protocols and associated methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003029845A2 (en) * 2001-10-01 2003-04-10 Vision Biosystems Limited Histological tissue specimen treatment
US20050186114A1 (en) * 2002-04-15 2005-08-25 Kurt Reinhardt Automated high volume slide processing system
GB2432669A (en) * 2005-11-29 2007-05-30 Leica Microsystems Tissue processor adaptable to different reagent containers
WO2010048631A2 (en) * 2008-10-24 2010-04-29 Biomicro, Inc. Modular system for performing laboratory protocols and associated methods

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