WO2023082030A1 - 实验小鼠尾静脉注射辅助装置 - Google Patents

实验小鼠尾静脉注射辅助装置 Download PDF

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Publication number
WO2023082030A1
WO2023082030A1 PCT/CN2021/000198 CN2021000198W WO2023082030A1 WO 2023082030 A1 WO2023082030 A1 WO 2023082030A1 CN 2021000198 W CN2021000198 W CN 2021000198W WO 2023082030 A1 WO2023082030 A1 WO 2023082030A1
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Prior art keywords
mouse
tail vein
tail
ring
vein injection
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PCT/CN2021/000198
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English (en)
French (fr)
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吴琪
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吴琪
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Priority to PCT/CN2021/000198 priority Critical patent/WO2023082030A1/zh
Publication of WO2023082030A1 publication Critical patent/WO2023082030A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals

Definitions

  • the invention is applicable to the field of biomedicine, and specifically relates to the technical field of animal experiment equipment.
  • Tail vein injection is one of the common operations in mouse experiments and is widely used in medical and life science research.
  • the mouse tail vein is small and covered by the skin of the tail, making it difficult to distinguish its position with the naked eye. And the mice are difficult to fix, and the mice often shake and convulse violently when the syringe is inserted into the needle.
  • the above reasons make the tail vein injection technique difficult to master, and the failure rate of novices is extremely high. Therefore, properly fixing the mice and imaging the tail vein are the key factors to improve the success rate of tail vein injection.
  • the inventor provides a mouse tail vein injection auxiliary device with small size, light weight, low cost, simple structure, easy operation, high reproducibility rate at home, and strong industrial production feasibility, aiming at improving the success rate of injection.
  • the background technology required for the successful implementation of the present invention is: proficiency in the basic knowledge and skills of animal experiments, familiarity with relevant anatomical knowledge of mouse tail blood vessels; and having a certain level of electrical knowledge.
  • the invention to be applied for an international utility model patent is called a mouse lateral tail vein injection assisting device, including a mouse tail vein injection fixer and an experimental mouse tail vein injection imager. a relatively independent component.
  • the mouse tail vein injection fixator is described as “this fixer”, “the fixer” and “fixer” hereinafter.
  • the mouse tail vein injection imaging apparatus is described as “this imaging apparatus”, “the imaging apparatus” and “imaging apparatus” hereinafter.
  • the supporting use of the fixer and the imager can greatly facilitate tail vein injection, reduce the difficulty of injection, and improve the success rate of injection.
  • This fixer can be used as a mouse fixer alone, allowing users to perform tail vein injection operations on mice under direct vision with naked eyes.
  • This imager can be used alone as a tail vein imager and used in conjunction with other mouse fixation devices. Although the two can be used independently, they can be used together to maximize the advantages of each other, so they are considered as one invention at the request of the inventor.
  • the fixer is composed of parts such as a fixing tube and a fixing table, wherein the fixing tube includes a fixing tube, long and short pistons and screw clips, and the fixing table includes a fixing table, an anti-slip foot pad and a plastic suction cup.
  • the imaging device is composed of rings, LED lamp beads and power supplies, among which the ring includes semi-closed rings, rat tail card slots, LED light boxes, back covers of light box and related model identifications, LED lamp beads include lamp beads, wires, One end of the terminal, the power supply includes batteries, battery boxes, variable resistors, wires, and the other end of the terminal.
  • the user Before starting the mouse tail vein injection, the user can fix the fixer on the edge of the experimental table, install the imager, fix the mouse in the fixer, and put the ring on the index finger or middle finger of the non-injecting hand. Place the mouse tail in the above-mentioned mouse tail card slot, turn on the power switch, and the imager will start to act on the mouse tail.
  • the tail vein of the mouse appears as a thin black line under the illumination of LED lamp beads. After successful tail vein injection, the blood is diluted by the drug solution, and the thin black line disappears.
  • the fixer is made up of parts such as a fixing tube and a fixing platform, wherein the fixing tube includes a fixing tube, long and short pistons and screw clips, and the fixing platform includes a fixing platform, a non-slip foot pad and a plastic suction cup. Its function is to fix the mouse body when the user injects the mouse into the tail vein, and can effectively fix the mouse within 15-45g.
  • the fixed tube adopts a material-saving fence design with multiple gaps, which allows the mice to breathe freely and is also convenient for the user to observe the mice.
  • the fixed tube can expose the entire mouse tail to the user's field of vision, ensuring that the injection range is the entire length of the mouse tail, and is suitable for situations where multiple injections are required.
  • the fixed tube can be rotated 360° to ensure that the side tail vein is directly above.
  • the fixed tube has a smooth round bottom, which enables the mouse feces to flow out of the device by itself without laborious cleaning.
  • the piston is divided into long and short pistons to accommodate mice of different weights.
  • the short piston fixes 15-30g mice, and the long piston fixes 30-45g mice.
  • the piston enters the fixed tube through the dual-purpose slit on the fixed tube leading directly to the bottom of the tube. Drag the mouse to the bottom of the tube and put a piston to block the head of the mouse, so as to completely immobilize the mouse body.
  • the movable screw clip is attached to the long and short pistons to function, and can be loosened or tightened. When loosening, the piston can move freely in the fixed tube, and when tightened, the piston can be fixed at a specific position in the fixed tube.
  • the imaging device is composed of a ring, LED lamp beads and power supply, wherein the ring includes a semi-closed ring, a rat tail card slot, an LED light box, a back cover of the light box and related model identifications, and the LED light beads include lamp beads, electric wires , one end of the connection terminal, the power supply includes a battery, a battery box, a variable resistor, wires, and the other end of the connection terminal. Its function is to illuminate the mouse tail to display the tail vein when the user injects the tail vein of the mouse, and is suitable for various types of mice.
  • the ring includes three models, large, medium and small. Users can choose the appropriate model to wear according to the thickness of their fingers. No matter how the model of the ring changes, the structure is the same: it consists of a semi-closed ring, a rat tail card slot, an LED light box, a light box back cover and related model marks.
  • the half-closed ring can be worn on the index or middle finger of the user's non-injecting hand.
  • the mouse tail card slot is used to place the mouse tail. Any part of the mouse tail can be placed in the mouse tail slot.
  • the LED lamp box can accommodate yellow LED lamp beads or green LED lamp beads described below. The LED light shines through the opening on the LED light box into the mouse tail slot, and then illuminates the mouse tail to display the tail vein.
  • the back cover of the light box is used to fix the LED lamp beads.
  • the difference between the large, medium and small models of the ring is reflected by the diameter of the semi-closed ring, and the size and shape of the remaining components are
  • LED beads include yellow light and green light with the same structure and size. Yellow light LED beads have strong penetrating power and are suitable for imaging of small white mice and small black mice. Green light LED beads are soft and suitable for The imaging effect of mice is obvious.
  • the LED lamp bead is connected to the power supply through the wires and terminals described below, and it can emit light after the power switch is turned on.
  • the LED lamp beads are placed in the LED light box on the above-mentioned ring during use, and are fixed by the back cover of the light box.
  • the LED lamp beads can enter the light box of any one of the large, medium and small models of the ring, that is, two LED lamp beads are suitable for three rings.
  • the main body of the power supply is a battery and a battery box.
  • the battery is any one of the existing No. 5 alkaline dry batteries on the market.
  • the battery box is a battery box with two AA alkaline dry batteries connected in series, that is, two AA alkaline dry batteries can be placed in series in the battery box as a power supply.
  • the battery box must also have enough room to accommodate a variable resistor.
  • the variable resistor can be any one of the existing small and micro resistors in the market.
  • the image display device includes a female connection terminal connected with electric wires and two male connection terminals connected with electric wires.
  • the imager includes one male connection terminal with wires and two female connection terminals with wires.
  • the connection terminal can be any one of the existing small and micro connection terminals in the market. This manual selects the first case for illustration.
  • the female terminal is connected to the battery box through the attached wire to supply power for the imager.
  • One male terminal is connected to the yellow LED lamp bead through the attached wire, and the other male terminal is connected to the green LED lamp bead through the attached wire.
  • One female terminal corresponds to two male terminals, so that one power supply can be adapted to two lamp beads.
  • the wires are connected to the battery box and the LED lamp beads by welding.
  • a complete closed circuit can be realized by docking the female head and the male head of the terminal block, and the LED lamp beads can emit light after the power switch is turned on.
  • the variable resistor is placed on the battery box, and the user adjusts the current by adjusting the variable resistor, thereby adjusting the brightness of the LED lamp bead to meet the needs of different indoor lighting for different light brightness.
  • One-to-two connection terminals are used to connect the power supply and LED lamp beads, so that one power supply can be adapted to two LED beads, which meets the needs of different lights during tail vein injection of different mice.
  • Fig. 1 is a schematic diagram of the structure of the present invention.
  • the number 1 is the fixed tube
  • 2 is the fixed table
  • 3 is the ring
  • 4 is the LED lamp bead
  • 5 is the power supply.
  • Fig. 2 is a schematic diagram of the second structure of the present invention.
  • the number 1 is the fixed tube
  • 2 is the fixed table
  • 3 is the ring
  • 4 is the LED lamp bead
  • 5 is the power supply.
  • Fig. 3 is a schematic diagram of the structure of the fixer.
  • numeral 11 is a fixed tube
  • 12 is a (long/short) piston
  • 13 is a screw clip
  • 21 is a fixed platform
  • 22 is a non-slip foot pad
  • 23 is a plastic suction cup.
  • Fig. 4 is a schematic diagram of the structure of the fixed tube.
  • Fig. 5 is a schematic diagram of the structure of the fixed platform.
  • numeral 21 is a fixed platform
  • 22 is a non-slip foot pad
  • 23 is a plastic suction cup
  • 24 is a storage space.
  • Fig. 6 is a schematic diagram of the structure of the ring.
  • the number 32 is a semi-closed ring
  • 33 is a rat tail card slot
  • 34 is an LED light box
  • 35 is the back cover of the light box.
  • Fig. 7 is a schematic diagram of the structure of the LED lamp bead and the power supply.
  • the number 41 is the LED lamp bead
  • 42 is the electric wire
  • 43 is one end of the terminal block
  • 51 is the battery box
  • 52 is the variable resistor
  • 53 is the electric wire
  • 54 is the other end of the terminal block.
  • the fixing tube, the fixing table, the ring and the back cover of the ring light box can be manufactured by 3D printing technology or other molding technology, the material of the fixing tube and the fixing table can be photosensitive resin, and the material of the ring can be completely opaque materials such as nylon.
  • the stereolithography process of the fixing tube and the fixing table is simple and easy to recreate. Stereolithography documentation for the ring will be provided as an attachment if required and convenient.
  • the auxiliary device for tail vein injection of mice in this experiment is about 1100 cm 3 and 200 g, which can be described as small in size and light in weight.
  • the cost is low and the manufacturing process is simple, and the user can buy most of the required parts at a very low price in the market, and can make it at home according to the above-mentioned disclosed manufacturing method.
  • the inventor encourages potential users to make the auxiliary device for tail vein injection of experimental mice for their own use, but does not allow any application with commercial purposes, including production, publicity, sales, etc.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Husbandry (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

一种实验小鼠尾静脉注射辅助装置，属于一种动物实验设备，可用于包括医学在内的生命科学研究，具体用于实验小鼠尾静脉注射给药。该操作是一种小鼠实验常用操作，但成功率较低。本装置通过实现鼠体固定和尾静脉显像降低尾注难度、提高尾注成功率。本装置包括固定器和显像指环两个相对独立的部件。固定器由固定管（1）和固定台（2）等组成；显像指环由指环（3）、LED灯珠（4）和电源（5）等部件组成。本装置比较明显的特点有：体积小、重量轻、固定器可360°旋转保证静脉朝上、显像指环可戴在手上照亮鼠尾。

Description

实验小鼠尾静脉注射辅助装置 技术领域
本发明适用于生物医药领域，具体涉及动物实验设备技术领域。
背景技术
尾静脉注射给药是小鼠实验的常用操作之一，广泛应用于医学及生命科学研究中。小鼠尾静脉细小，被尾部皮肤覆盖，难以用肉眼分辨其位置。且小鼠难以固定，伴随注射器进针时，小鼠往往会剧烈抖动抽搐。上述原因导致尾静脉注射技术很难掌握，新手失败率极高，因此妥善固定小鼠并对尾静脉显像是提高尾静脉注射成功率的关键因素。发明人提供一款体积小、重量轻、成本低廉、结构简单、操作容易、在家自制复现率高、工业生产可行性强的小鼠尾静脉注射辅助装置，旨在提高注射成功率。
本发明成功实施所需要的背景技术为：熟练掌握动物实验的基本知识和技能，熟悉小鼠尾部血管相关解剖知识；具备一定水平的电学知识。
发明内容
本拟申请国际实用新型专利的发明名为实验小鼠尾静脉注射辅助装置(a mouse lateral tail vein injection assisting device)，包括实验小鼠尾静脉注射固定器和实验小鼠尾静脉注射显像仪两个相对独立的部件。小鼠尾静脉注射固定器在后文中描述为“本固定器”、“所述固定器”、“固定器”。小鼠尾静脉注射显像仪在后文中描述为“本显像仪”、“所述显像仪”、“显像仪”。本固定器与本显像仪配套使用可以极大便利尾静脉注射、降低注射难度、提高注射成功率。另：本固定器可单独用作小鼠固定器允许使用者在裸眼直视下对小鼠进行尾静脉注射操作。本显像仪可单独用作尾静脉显像仪与其它小鼠固定装置配合使用。两者虽可单独使用，但配套使用可将彼此的优势发挥到最大，故应发明人要求，将其视为一个发明。
本固定器由固定管和固定台等部件组成，其中固定管包括固定管、长短活塞和螺丝卡子，固定台包括固定台、防滑脚垫和塑料吸盘。本显像仪由指环、LED灯珠和电源等部件组成，其中指环包括半闭指环、鼠尾卡槽、LED灯盒、灯盒后盖和相关型号标识，LED灯珠包括灯珠、电线、接线端子的一头，电源包括电池、电池盒、可变电阻器、电线、接线端子的另一头。
使用者在开始小鼠尾静脉注射之前，可将固定器固定于实验桌边缘处，将显像仪安装好，将小鼠固定于固定器内，将指环戴在非注射手食指或中指上，将小鼠鼠尾放置在前文所述鼠尾卡槽内，将电源开关打开，显像仪即开始对小鼠鼠尾发生作用。小鼠尾静脉在LED灯珠照射下显示为一条黑色细线，成功进行尾静脉注射之后，血液被药液稀释，黑色细线消失。
一、固定器
所述固定器由固定管和固定台等部件组成，其中固定管包括固定管、长短活塞和螺丝卡子，固定台包括固定台、防滑脚垫和塑料吸盘。其作用是在使用者对小鼠进行尾静脉注射时固定鼠体，能实现15-45g以内小鼠的有效固定。
1.固定管采用省料栅栏设计，有多条缝隙，可以让小鼠自由呼吸，也方便使用者观察小鼠。其上有一条直通管底的两用缝隙，可以将装进固定管的小鼠从尾巴处拽至管底，也用来支撑螺丝卡子从而调整活塞在管内位置，有效固定鼠体。固定管可以让整条鼠尾暴露在使用者的视野中，确保注射范围为鼠尾全长，适用于需要进行多次注射的情况。进行尾注时，妥善固定小鼠并通过旋转小鼠体位使位于侧方的尾静脉处于正上方是成功进行注射的必要条件，本固定管可以360°旋转，保证尾部侧方静脉处于正上方。固定管为平滑圆底，可实现小鼠粪便自行流出装置外，无需费力清洗。
2.活塞分为长短两个活塞以适应不同重量的小鼠，短活塞固定15-30g小鼠，长活塞固定30-45g小鼠。活塞通过固定管上直通管底的两用缝隙进入固定管。将小鼠拽至管底后放入活塞堵住小鼠头部，从而彻底实现鼠体固定。
3.可活动螺丝卡子依附于长短活塞发生作用，可松可紧，转松时可使活塞在固定管内自由移动，转紧时可使活塞固定在固定管内某个具体位置。
4.固定台底部前方有两个圆形硅胶防滑脚垫，可减少固定器和实验桌的接触噪音和磨损，增大摩擦力。固定台底部后方有两个PVC材质的吸盘，在实验桌干净无灰且润湿的情况下可确保固定器牢固贴附实验桌。固定台底部后上方有六个凸起面，围成一个储物空间，可放置小型实验用具，或者在本发明中，该储物空间为放置电池盒而发明。固定台上方为半圆形支架，固定管以此支架为支撑点实现360°旋转，保证尾部侧方静脉处于正上方。
二、显像仪
所述显像仪由指环、LED灯珠和电源等部件组成，其中指环包括半闭指环、鼠尾卡槽、LED灯盒、灯盒后盖和相关型号标识，LED灯珠包括灯珠、电线、接线端子的一头， 电源包括电池、电池盒、可变电阻器、电线、接线端子的另一头。其作用是在使用者对小鼠进行尾静脉注射时照亮鼠尾显示尾静脉，适用于各种品类的小鼠。
1.指环包括大中小三个型号，使用者可根据手指粗细选择合适型号佩戴。本指环无论其型号如何变化，结构一样：由一个半闭指环、一个鼠尾卡槽、一个LED灯盒、一个灯盒后盖和相关型号标识组成。半闭指环可佩戴在使用者非注射手食指或中指上。鼠尾卡槽用来安置小鼠尾部。小鼠鼠尾的任何一段都可被安置在鼠尾卡槽内。LED灯盒可安置下文所述黄光LED灯珠或绿光LED灯珠。LED灯珠灯光透过LED灯盒上的开口照射到鼠尾卡槽里，进而照亮鼠尾，显示尾静脉。灯盒后盖用来固定LED灯珠。本指环大中小型号的区别通过半闭指环的直径体现，其余组成部分的大小外形等三种型号保持一致。
2.LED灯珠包括黄光和绿光两种结构大小一样的灯珠，黄光LED灯珠穿透力强，适用于小白鼠和小黑鼠的显像，绿光LED灯珠柔和，对小白鼠的显像效果明显。LED灯珠通过下文所述电线和接线端子与电源相连，电源开关打开后即可发光。LED灯珠在使用过程中放置在上文所述指环上的LED灯盒内，通过灯盒后盖固定。LED灯珠可进入所述指环大中小型号的任意一个的灯盒中，即两个LED灯珠适配三个指环。
3.电源主体为电池和电池盒。电池为市场上现有的五号碱性干电池的任意一种。电池盒为两节五号碱性干电池串联电池盒，即该电池盒里面可以串联方式安置两节五号碱性干电池充当电源。电池盒还必须具有足够的空间用以安置一个可变电阻器。该可变电阻器可为市场现有小微型电阻器的任意一种。
4.其它部件包括接线端子、电线和可变电阻器。所述显像仪包括一个连带电线的母头接线端子和两个连带电线的公头接线端子。或相反，所述显像仪包括一个连带电线的公头接线端子和两个连带电线的母头接线端子。该接线端子可为市场现有小微型接线端子的任意一种。本说明书选取第一种情况做说明。母头接线端子通过所连带电线与电池盒相连，为显像仪供电。一个公头接线端子通过所连带电线与黄光LED灯珠相连，另一个公头接线端子通过所连带电线与绿光LED灯珠相连。接线端子一个母头对应两个公头，实现一个电源适配两个灯珠。电线与电池盒、LED灯珠通过焊接法连接。接线端子母头和公头对接即可实现一个完整的闭合电路，电源开关打开后LED灯珠即可发光。可变电阻器安置于电池盒上，使用者通过调节可变电阻器调节电流大小，从而调节LED灯珠的亮度，满足不同室内光照对不同灯光亮度的需求。采用一对二形式的接线端子连接电源和LED灯珠，使得一个电源可以适配两个LED珠，满足了不同小鼠尾静脉注射过程 中对不同灯光的需求。
附图说明
图1为本发明结构示意图一。其中数字1是固定管，2是固定台，3是指环，4是LED灯珠，5是电源。
图2为本发明结构示意图二。其中数字1是固定管，2是固定台，3是指环，4是LED灯珠，5是电源。
图3为所述固定器结构示意图。其中数字11是固定管，12是(长/短)活塞，13是螺丝卡子，21是固定台，22是防滑脚垫，23是塑料吸盘。
图4为所述固定管结构示意图。
图5为所述固定台结构示意图。其中数字21是固定台，22是防滑脚垫，23是塑料吸盘，24是储物空间。
图6为所述指环结构示意图。其中数字32是半闭指环，33是鼠尾卡槽，34是LED灯盒，35是灯盒后盖。
图7为所述LED灯珠和电源结构示意图。其中数字41是LED灯珠，42是电线，43是接线端子的一头，51是电池盒，52是可变电阻器，53是电线，54是接线端子的另一头。
本发明的具体安装及实施方式
用湿毛巾擦干净实验桌，将固定台放在实验桌边缘位置处(便于给实验鼠做实验)，稍用力按压吸盘排走里面的空气，此时固定台牢固吸附在桌面上。打开电池盒后盖，放入两节五号碱性干电池，盖上后盖。将电池盒放入固定台底部后上方的储物空间。将任一LED灯珠放入选择的指环灯盒内，盖上灯盒后盖。将接线端子公头插入母头内。沿着固定管上直通底部的缝隙拖拽小鼠尾巴将其拽至固定管底部，然后将活塞插入固定管前端，轻轻往底部方向滑动至合适位置，拧紧螺丝卡子固定活塞，此时鼠体固定在固定管中。将固定管安装到固定台支架上，慢慢旋转固定管直至侧方静脉朝向正上方，实验鼠固定完成。打开显像仪电源开关，调整可变电阻器使得LED灯的亮度满意即可开始尾静脉注射操作。
本发明的一种可行制作方法
一、制作固定器及指环
所述固定管和固定台、指环和指环灯盒后盖可用3维打印技术或其它成型技术制造，固定管和固定台材料可为光敏树脂，指环材料可为尼龙等完全不透光材料。固定管和固 定台的立体光刻工艺简单易重建。指环的立体光刻工艺文件将在需要的并且方便的情况下作为附件提供。
二、制作一个黄光LED灯珠和电源电路
在任一形式的市场上购买所需原材料，包括：两节五号碱性干电池的串联电池盒、50R 3362P电位器、接线端子一对、Φ1mm电线90mm+250mm、5W黄光LED灯珠一个。
1.通过铣削钻孔等技术在电池盒的开关附近接入50R 3362P电位器，焊接电路使得电位器串联于开关和阳极电极片之间。
2.选取250mm电线，焊接接线端子母端引线至电池盒。
3.选取90mm电线，焊接接线端子公端引线至LED灯珠。
本发明的优势
本实验小鼠尾静脉注射辅助装置约为1100cm 3、200g，可谓体积小、重量轻。成本低廉、制作过程简单，使用者可以在市场上以极低的价格买到所需的大部分零部件，在家即可按照上述公开的制作方法自行制作。发明人鼓励潜在使用者自己动手制作供自己使用的实验小鼠尾静脉注射辅助装置，但不允许任何具有商业目的应用，包括制作、宣传、售卖等。

Claims (7)

  1. [根据细则91更正 30.08.2022]　
    实验小鼠尾静脉注射辅助装置，包括固定器和显像仪两大部分，其特征在于：所述固定器由固定管（图1.1）和固定台（图1.2）等部件组成，所述固定台（图1.2）顶部支架可以固定固定管（图1.1）,所述固定管（图1.1）内腔设置有长短活塞（图3.12）.所述显像仪由指环（图1.3）、LED灯珠（图1.4）和电源（图1.5）等部件组成，所述LED灯珠（图1.4）上连接有电线（图7.53）,电线上焊接有接线端子的公头（图7.43）；所述电源（图1.5）上连接有电线（图7.42）,电线上焊接有接线端子的母头（图7.54）:所述灯珠（图7.41）可以并且应该放置在所述指环（图1.3）的灯盒（图6.34）里面.
  2. [根据细则91更正 30.08.2022]　
    根据权利要求1所述的实验小鼠尾静脉注射辅助装置，其特征在于：所述固定管（图1.1）为省料栅栏式设计.其上有多条平行小缝隙和一条直通管底的两用大缝隙，让小鼠得以自由呼吸。
  3. [根据细则91更正 30.08.2022]　
    根据权利要求1所述的实验小鼠尾静脉注射辅助装置，其特征在于：所述长短活塞（图3.12）远实验鼠端设置有螺丝卡子（图3.13）、近实验鼠端设计有方便活塞进入固定管的滑坡，同时近实验鼠端有可固定小鼠头端的锥形空间.
  4. [根据细则91更正 30.08.2022]　
    根据权利要求1所述的实验小鼠尾静脉注射辅助装置.其特征在于：所述固定台（图1.2）底部前方设置有防滑脚垫（图5.22）、底部后方设置有固定吸盘（图5.23）、底部后上方由若干凸起面围成一个储物空间（图5.24）,所述固定台（图1.2）上方为半圆形支架,固定管（图1.1）以此支架为支撑点实现360°旋转。
  5. [根据细则91更正 30.08.2022]　
    根据权利要求1所述的实验小鼠尾静脉注射辅助装置，其特征在于：所述指环（图1.3）包括大中小三种型号，使用者可根据手指粗细选择合适型号佩戴，所述指环（图1.3）无论其型号如何变化，结构一样由半闭指环（图6.32）、鼠尾卡槽（图6.33）、LED灯盒（图6.34）以及灯盒后盖（图6.35）组成。
  6. [根据细则91更正 30.08.2022]　
    根据权利要求1所述的实验小鼠尾静脉注射辅助装置，其特征在于：所述灯珠（图7.41）包括黄光和绿光两种结构外形一样的灯,与灯珠（图7.41）所连电线（图7.53）上焊接有一个微型电阻，所述灯珠（图7.41）可以而且应该放置在指环（图L3）的灯盒（图&34）里面,由灯盒后盖（图6.35）固定.通电后灯光经过灯盒的透光孔发生作用，照亮鼠尾卡槽（图6.33）,从而照亮鼠尾。
  7. [根据细则91更正 30.08.2022]　
    根据权利要求1所述的实验小鼠尾静脉注射辅助装置，其特征在于：所述电源（图1.5）上设置有可变电阻器（图7.52）、电线（图7.42）和母头接线端子（图7.54）。
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CN204734571U (zh) * 2015-05-19 2015-11-04 青海师范大学 一种小鼠尾静脉注射装置
CN208709863U (zh) * 2018-03-11 2019-04-09 南京卡尔文生物科技有限公司 小鼠尾注射静脉显像仪
CN109965850A (zh) * 2019-05-08 2019-07-05 杭州多泰科技有限公司 一种双光源小鼠尾静脉显像仪器
KR102038991B1 (ko) * 2019-07-30 2019-10-31 박성걸 소동물 미정맥 투여 또는 채혈 보정장치
CN110974472A (zh) * 2020-01-03 2020-04-10 华中科技大学同济医学院附属协和医院 小鼠尾静脉注射固定装置及其使用方法
CN210932017U (zh) * 2019-08-16 2020-07-07 天津市第三中心医院 一种鼠尾采血及静脉注射仪
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN204734571U (zh) * 2015-05-19 2015-11-04 青海师范大学 一种小鼠尾静脉注射装置
CN208709863U (zh) * 2018-03-11 2019-04-09 南京卡尔文生物科技有限公司 小鼠尾注射静脉显像仪
CN109965850A (zh) * 2019-05-08 2019-07-05 杭州多泰科技有限公司 一种双光源小鼠尾静脉显像仪器
KR102038991B1 (ko) * 2019-07-30 2019-10-31 박성걸 소동물 미정맥 투여 또는 채혈 보정장치
CN210932017U (zh) * 2019-08-16 2020-07-07 天津市第三中心医院 一种鼠尾采血及静脉注射仪
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