WO2023081377A3 - Compositions comprising an rna guide targeting ciita and uses thereof - Google Patents
Compositions comprising an rna guide targeting ciita and uses thereof Download PDFInfo
- Publication number
- WO2023081377A3 WO2023081377A3 PCT/US2022/048989 US2022048989W WO2023081377A3 WO 2023081377 A3 WO2023081377 A3 WO 2023081377A3 US 2022048989 W US2022048989 W US 2022048989W WO 2023081377 A3 WO2023081377 A3 WO 2023081377A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- rna guide
- sequence
- ciita
- rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
Abstract
The present invention relates to compositions comprising RNA guides targeting CIITA, processes for characterizing the compositions, cells comprising the compositions, and methods of using the compositions. The invention provides a composition comprising an RNA guide, wherein the RNA guide comprises (i) a spacer sequence that is substantially complementary to a target sequence within a CIITA gene and (ii) a direct repeat sequence; wherein the target sequence is adjacent to a protospacer adjacent motif (PAM) comprising the sequence 5 '-NTTN-3'.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163276229P | 2021-11-05 | 2021-11-05 | |
US63/276,229 | 2021-11-05 | ||
US202163294121P | 2021-12-28 | 2021-12-28 | |
US63/294,121 | 2021-12-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2023081377A2 WO2023081377A2 (en) | 2023-05-11 |
WO2023081377A3 true WO2023081377A3 (en) | 2023-09-14 |
Family
ID=86242120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2022/048989 WO2023081377A2 (en) | 2021-11-05 | 2022-11-04 | Compositions comprising an rna guide targeting ciita and uses thereof |
Country Status (2)
Country | Link |
---|---|
TW (1) | TW202334421A (en) |
WO (1) | WO2023081377A2 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021158918A1 (en) * | 2020-02-05 | 2021-08-12 | Danmarks Tekniske Universitet | Compositions and methods for targeting, editing or modifying human genes |
WO2021202800A1 (en) * | 2020-03-31 | 2021-10-07 | Arbor Biotechnologies, Inc. | Compositions comprising a cas12i2 variant polypeptide and uses thereof |
WO2023039534A2 (en) * | 2021-09-10 | 2023-03-16 | Arbor Biotechnologies, Inc. | Compositions comprising a cas12i polypeptide and uses thereof |
-
2022
- 2022-11-04 TW TW111142267A patent/TW202334421A/en unknown
- 2022-11-04 WO PCT/US2022/048989 patent/WO2023081377A2/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021158918A1 (en) * | 2020-02-05 | 2021-08-12 | Danmarks Tekniske Universitet | Compositions and methods for targeting, editing or modifying human genes |
WO2021202800A1 (en) * | 2020-03-31 | 2021-10-07 | Arbor Biotechnologies, Inc. | Compositions comprising a cas12i2 variant polypeptide and uses thereof |
WO2023039534A2 (en) * | 2021-09-10 | 2023-03-16 | Arbor Biotechnologies, Inc. | Compositions comprising a cas12i polypeptide and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
TW202334421A (en) | 2023-09-01 |
WO2023081377A2 (en) | 2023-05-11 |
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