WO2023067031A3 - Dosage - Google Patents
Dosage Download PDFInfo
- Publication number
- WO2023067031A3 WO2023067031A3 PCT/EP2022/079144 EP2022079144W WO2023067031A3 WO 2023067031 A3 WO2023067031 A3 WO 2023067031A3 EP 2022079144 W EP2022079144 W EP 2022079144W WO 2023067031 A3 WO2023067031 A3 WO 2023067031A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- monoclonal antibodies
- colour
- protein
- vitro potency
- potency assay
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000000338 in vitro Methods 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 239000011324 bead Substances 0.000 title 1
- 229960005037 meningococcal vaccines Drugs 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940124731 meningococcal vaccine Drugs 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention concerne un immunoessai multiplex pour analyser un vaccin antiméningococcique et évaluer la puissance relative in vitro de celui-ci (IVRP). L'invention concerne également des anticorps monoclonaux qui se lient aux protéines méningococciques à l'intérieur du vaccin, et en particulier des anticorps monoclonaux qui sont bactéricides pour un méningocoque et/ou qui reconnaissent des épitopes conformationnels dans les protéines méningococciques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB2115077.6A GB202115077D0 (en) | 2021-10-21 | 2021-10-21 | Assay |
GB2115077.6 | 2021-10-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2023067031A2 WO2023067031A2 (fr) | 2023-04-27 |
WO2023067031A3 true WO2023067031A3 (fr) | 2023-06-01 |
Family
ID=78805967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2022/079144 WO2023067031A2 (fr) | 2021-10-21 | 2022-10-19 | Dosage |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB202115077D0 (fr) |
WO (1) | WO2023067031A2 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009143168A2 (fr) * | 2008-05-19 | 2009-11-26 | Novartis Ag | Essais de vaccin |
WO2012031271A1 (fr) * | 2010-09-04 | 2012-03-08 | Novartis Ag | Dosages d'anticorps bactéricides pour évaluer l'immunogénicité et la puissance de vaccins contre le méningocoque constitués de saccharides capsulaires |
WO2013132040A2 (fr) * | 2012-03-08 | 2013-09-12 | Novartis Ag | Dosage de puissance in vitro pour des vaccins méningococciques à base de protéine |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
US5698438A (en) | 1994-10-18 | 1997-12-16 | Oregon Health Sciences University | Bacterial hemoglobin receptor gene |
IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
US6180111B1 (en) | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
NZ541361A (en) | 1998-05-01 | 2008-04-30 | Inst Genomic Research | Neisseria meningitidis antigens and compositions relating to SEQ ID Nos:2916, 2918 and 2920 |
RU2002117308A (ru) | 1999-11-29 | 2004-03-10 | Чирон Спа (It) | 85 кДа АНТИГЕН NEISSERIA |
AU2001280883A1 (en) | 2000-07-27 | 2002-02-13 | The Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
GB0213622D0 (en) | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
JP2012512240A (ja) | 2008-12-17 | 2012-05-31 | ノバルティス アーゲー | ヘモグロビン受容体を含む髄膜炎菌ワクチン |
GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
EP3607967A1 (fr) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Polypeptides modifiés du méningocoque fhbp |
-
2021
- 2021-10-21 GB GBGB2115077.6A patent/GB202115077D0/en not_active Ceased
-
2022
- 2022-10-19 WO PCT/EP2022/079144 patent/WO2023067031A2/fr unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009143168A2 (fr) * | 2008-05-19 | 2009-11-26 | Novartis Ag | Essais de vaccin |
WO2012031271A1 (fr) * | 2010-09-04 | 2012-03-08 | Novartis Ag | Dosages d'anticorps bactéricides pour évaluer l'immunogénicité et la puissance de vaccins contre le méningocoque constitués de saccharides capsulaires |
WO2013132040A2 (fr) * | 2012-03-08 | 2013-09-12 | Novartis Ag | Dosage de puissance in vitro pour des vaccins méningococciques à base de protéine |
Non-Patent Citations (5)
Title |
---|
BANDIERA SILVIO ET AL: "A single immunogenicity assay for testing potency of combination DTaP vaccines: Simultaneous quantitation of anti-DT, anti-TT, anti-PTxd and anti-FHA antibodies in Guinea-pig serum with a Luminex -xMAP bead-based serological assay", BIOLOGICALS, ACADEMIC PRESS LTD., LONDON, GB, vol. 61, 23 August 2019 (2019-08-23), pages 15 - 21, XP085813642, ISSN: 1045-1056, [retrieved on 20190823], DOI: 10.1016/J.BIOLOGICALS.2019.08.002 * |
MASDOR NOOR AZLINA ET AL: "Subtractive inhibition assay for the detection of Campylobacter jejuni in chicken samples using surface plasmon resonance", SCIENTIFIC REPORTS, vol. 9, no. 1, 1 January 2019 (2019-01-01), pages 13642, XP093022376, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754509/pdf/41598_2019_Article_49672.pdf> DOI: 10.1038/s41598-019-49672-2 * |
SKOTTRUP ET AL: "Monoclonal antibodies for the detection of Puccinia striiformis urediniospores", MYCOLOGICAL RESEARCH, ELSEVIER, GB, vol. 111, no. 3, 1 March 2007 (2007-03-01), pages 332 - 338, XP022015904, ISSN: 0953-7562, DOI: 10.1016/J.MYCRES.2006.11.010 * |
SKOTTRUP ET AL: "Rapid determination of Phytophthora infestans sporangia using a surface plasmon resonance immunosensor", JOURNAL OF MICROBIOLOGICAL METHODS, ELSEVIER, AMSTERDAM, NL, vol. 68, no. 3, 16 February 2007 (2007-02-16), pages 507 - 515, XP005892088, ISSN: 0167-7012, DOI: 10.1016/J.MIMET.2006.10.011 * |
YIXIAN WANG ET AL: "Subtractive inhibition assay for the detection of E.coli O157:H7 using surface plasmon resonance", vol. 11, no. 3, 1 January 2011 (2011-01-01), pages 2728 - 2739, XP003029230, ISSN: 1424-8220, Retrieved from the Internet <URL:http://www.mdpi.com/1424-8220/11/3/2728> [retrieved on 20110301], DOI: 10.3390/S110302728 * |
Also Published As
Publication number | Publication date |
---|---|
WO2023067031A2 (fr) | 2023-04-27 |
GB202115077D0 (en) | 2021-12-08 |
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