WO2023059298A1 - A cream comprising fenugreek for prevention of zoster, wound and skin infections and for treatment of migraine, arthritis - Google Patents

A cream comprising fenugreek for prevention of zoster, wound and skin infections and for treatment of migraine, arthritis Download PDF

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Publication number
WO2023059298A1
WO2023059298A1 PCT/TR2022/051077 TR2022051077W WO2023059298A1 WO 2023059298 A1 WO2023059298 A1 WO 2023059298A1 TR 2022051077 W TR2022051077 W TR 2022051077W WO 2023059298 A1 WO2023059298 A1 WO 2023059298A1
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Prior art keywords
wounds
cream
wound
diseases
fenugreek
Prior art date
Application number
PCT/TR2022/051077
Other languages
French (fr)
Inventor
Omer ELBASHEER
Original Assignee
Elbasheer Omer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from TR2021/015672 external-priority patent/TR2021015672A2/en
Application filed by Elbasheer Omer filed Critical Elbasheer Omer
Publication of WO2023059298A1 publication Critical patent/WO2023059298A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Definitions

  • the present invention relates to a cream including herbal components with antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics and which is suitable for use in prevention and treatment of wound and skin infections, migraine, arthritis and zoster diseases or in elimination of the symptoms which result from these diseases.
  • the subject matter cream can be used for the treatment of the mentioned diseases for the related technical field and has high bio-availability and provides reduction of the inflammation for healing of wound.
  • Skin is the widest organ which protects animal and human body against external factors and which provides heat isolation. Skin has body protective function against mechanical, chemical and biological external factors for animal and human body.
  • wounds can be mild such that the skin can repair itself in short duration; and in some cases, healing of the wounds may delay or may stop.
  • wounds which are not healed within duration between 4-6 weeks are named non-healing or chronic wound.
  • Various internal-sourced factors (factors which belong to the body of a person) or external-sourced factors can determine the healing duration of the wound.
  • Wound and skin infections mean that the tissues are infected by one or more kind of microorganisms. Said infections trigger the immune system of the body and they can lead to tissue damage and inflammation in the body and decelerate the healing process.
  • the reasons which avoid healing of the wound are diagnosed and these reasons are eliminated as much as possible and a suitable medium is provided for healing for treatment of wound and skin infections.
  • the treatments for healing of the skin and wound infections can show variety in a range from usage of ointments, including antibiotics, to surgical operations depending on the intensity of the infections.
  • creams, ointments, sprays, gels and disinfectants which mostly include synthetic components, are used for the treatment of wound and skin infections. These creams hardly include herbal active substance or do not include any herbal active substance. Pharmaceutical compositions including a small number of herbal components can show small amount of synergic effect.
  • Synthetic components (components which are obtained by means of chemical methods) can show side effects for some patients and can lead to an unfavorable condition because they can have a toxic effect. Because of such reasons, usage of herbal-based components which are ideal for skin and wound care and which are beneficial for health and which have high bio-availability increases every passing day in the related technical field.
  • Migraine is a kind of head ache which can affect daily life of a patient and which can lead to limitation in daily activities of the patient.
  • migraine begins in the periphery of back of the neck, temporal or eyes and can become denser depending on the type of the ache.
  • compositions which include herbs at higher concentrations and which show favorable effect for the treatment in the course of the wound and skin infections, zoster and migraine diseases and which eliminate the side effects of the drugs having a chemical form.
  • the document with number TR2021/00190 can be shown as an example for the known state of the art.
  • the invention relates to a drug which includes herbs and which is used in treatment of virus-sourced diseases like chronic sinusitis, influenza, herpes zoster, herpes simplex, corona virus and in treatment of liver lesions and reinforcement of the immune system and in prevention of reproduction of cancer cells and which is in nose drop, throat spray, pastille, soft gelatin capsule, cream and ointment form including powder mixture obtained by means of extraction and lyophilization method from the ecballium elaterium herb fruit, which is also known as fructus elateri, and foliages and stem and roots.
  • the document with number TR2020/0156 can be shown.
  • the invention relates to an herbal support cream which is easily applicable and which supports treatment and which eliminates inflammation and which heals wound and which has bitter gourd extract, oil, vaseline, stearic acid, alcohol, isopropyl myristate, glycerine and water ingredient.
  • compositions including herbal components are needed to be obtained which have antiviral, antibacterial, antifungal, antiinflammatory, analgesic characteristics and which shall not lead to any side effect or any toxic effect for human and animal body.
  • the present invention relates to a cream including herbal ingredient in order to be used in prevention and treatment of wound and skin infections and migraine, arthritis and zoster diseases and in elimination of the symptoms which result from these diseases, for eliminating the abovementioned disadvantages and for bringing new advantages to the related technical field.
  • An object of the present invention is to obtain a cream including herbal component with high amounts and which does not comprise any side effect and any toxic effect for human and animal body.
  • An object of the present invention is to obtain a cream including herbal components which have antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
  • An object of the present invention is to obtain a cream including herbal ingredient and having high bio-availability.
  • the present invention relates to a cream for use in treatment of wound and skin infections, arthritis, migraine and zoster diseases or in elimination of the symptoms which result from these diseases.
  • the cream comprises powders, essence oils or mixtures thereof obtained by means of modern or traditional methods from fenugreeks which have antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
  • the subject matter cream comprises fenugreek at a value between 10% and 30% by weight.
  • the subject matter cream comprises fenugreek at a value of 20% by weight.
  • the subject matter cream comprises powders, essence oils or mixtures obtained by means of modern or traditional methods from black seed and fenugreek having antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
  • the wound is acute wounds, chronic wounds, infectious wounds, abrasion wounds, tear wounds, bruise wounds, trauma wounds, knife wounds, skin cuts, surgical wounds, gun wounds, thermal wounds, chemical wounds, bites, stings and electrical-sourced wounds.
  • the subject matter cream comprises at least one auxiliary substance.
  • said auxiliary substance is selected from the group formed by solvents, lubricants, filling substances, density enhancers, oils, emollients, penetration enhancers, binders, dispensers and preservatives.
  • the subject matter relates to a cream including herbal components with antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics and which is suitable for use in prevention and treatment of wound and skin infections, arthritis, migraine and zoster diseases or in elimination of the symptoms which result from these diseases, and is explained with references to examples without forming any restrictive effect only in order to make the subject more understandable.
  • the subject matter cream has a structure which has high bio-availability and which shall show effect for long duration by long-duration release on the skin.
  • the subject matter cream is applied to the region where skin integrity has been deteriorated, and treatment of skin and wound infections is realized (by laying or saturating).
  • the subject matter cream can be applied by laying or saturating to the region where the ache is sensed.
  • wound used within the scope of the present invention describes acute wounds, chronic wounds, infectious wounds, abrasion wounds, tear wounds, bruise wounds, trauma wounds, knife wounds, skin cuts, surgical wounds, gun wounds, thermal wounds, chemical wounds, bites, stings and electrical-sourced wounds.
  • the subject matter cream comprises powder forms of the herb, known frequently as fenugreek in the related technical field and named as Trigonella foenum-graecum in Latin and named as Semen Foenugraeci in medicine, obtained by means of traditional drying methods or by application of extraction and lyophilization methods and essence oils of said herb obtained by means of traditional and/or modern essence oil obtaining methods.
  • the subject matter cream can comprise fenugreek in solid powder form in nano or micro dimensions if preferred.
  • Said fenugreek comprises high amount of proteins, minerals and vitamins.
  • fenugreek comprises nitric compounds, phytin, choline, rutine, nicotine amid, coumarin, eholine, sentionine and cerpaine alkaloids, diosgenin, steroidal saponins and vitamins A, B and C. Since these and similar minerals, vitamins and various chemical compounds exist in fenugreek, it has been detected by the invention owner that fenugreek shows antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
  • fenugreek functions as the basic component in the invention because of its antiviral, antibacterial, antifungal, antiinflammatory, analgesic characteristics.
  • the subject matter cream comprises powder forms of the herb, known frequently as black seed in the related technical field and named as Nigella Steva in Latin, obtained by means of traditional drying methods or by application of extraction and lyophilization methods and essence oils of said herb obtained by means of traditional and/or modern essence oil obtaining methods.
  • the subject matter cream can comprise black seed in solid powder form in nano or micro dimensions if preferred.
  • Said black seed comprises quinone components like thymoquinone, thymohydroquinone, dithymoquinone at high ratios.
  • black seed also comprises thymol, limonene, carvacrol, p-cymene, longipholene, t-anethole benzene compounds. Since black seed comprises these and similar minerals, vitamins and various chemical compounds; black seed is used in the subject matter cream as an agent which has antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
  • the subject matter cream comprises fenugreek, and besides, it comprises black seed which can form synergic effect with fenugreek thanks to the compounds included in its body.
  • the subject matter cream comprises fenugreek oils and/or powders at a value between 10% and 30% by weight.
  • the subject matter cream comprises fenugreek oils and/or powders at a value of 20% by weight.
  • the subject matter cream comprises powders, essence oils or mixtures obtained from black seed and fenugreek by means of modern or traditional methods.
  • the invention owners expect a synergic effect related to increasing antiviral, antibacterial, antifungal, antiinflammatory, analgesic characteristics of the subject matter cream because these two components exist together.
  • synergic effect for the subject matter cream high antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics are obtained and the subject matter cream can be used in prevention and treatment of wound and skin infections and migraine and zoster diseases and in elimination of the symptoms which result from these diseases.
  • the subject matter cream comprises the powders, essence oils or mixtures of black seed obtained by means of modern or traditional methods and/or the powders, essence oils or mixtures of fenugreek obtained by means of modern or traditional methods, and the obtained cream can be used as pharmaceutical composition.
  • the subject matter cream is used as nutraceutical composition.
  • the subject matter cream can comprise at least one auxiliary substance.
  • Said auxiliary substances can be substances which can contribute to providing cream characteristic to the cream and obtaining a stable structure and showing long duration effect.
  • said auxiliary substances can be selected from a group formed by solvents, lubricants, filling substances, density enhancers, oils, emollients, penetration enhancers, binders, dispensers and preservatives.
  • the invention owner has detected that by using a cream comprising powders, essence oils or mixtures of fenugreek and black seed obtained by means of modern or traditional methods, said wound and skin infections are more rapidly healed and the treatment duration is shortened and rapid epithelization of the damaged region is provided.
  • the cream, including powders, essence oils or mixtures obtained by means of modern or traditional methods from fenugreek and black seed which trigger healing in the wound and skin infection region and afterwards which show modulating characteristic for the immune elements which can prevent healing, is controlled in a manner providing healing of inflammation wounds.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Natural Medicines & Medicinal Plants (AREA)
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  • Dermatology (AREA)
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Abstract

The present invention relates to a cream including herbal components with antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics and which is suitable for use in prevention and treatment of wound and skin infections, migraine and zoster diseases or in elimination of the symptoms which result from these diseases. In order to provide said characteristics, the cream comprises powders, essence oils or mixtures obtained from black seed and fenugreek by means of modern or traditional methods.

Description

A CREAM COMPRISING FENUGREEK FOR PREVENTION OF ZOSTER, WOUND AND SKIN INFECTIONS AND FOR TREATMENT OF MIGRAINE, ARTHRITIS
TECHNICAL FIELD
The present invention relates to a cream including herbal components with antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics and which is suitable for use in prevention and treatment of wound and skin infections, migraine, arthritis and zoster diseases or in elimination of the symptoms which result from these diseases. The subject matter cream can be used for the treatment of the mentioned diseases for the related technical field and has high bio-availability and provides reduction of the inflammation for healing of wound.
PRIOR ART
Skin is the widest organ which protects animal and human body against external factors and which provides heat isolation. Skin has body protective function against mechanical, chemical and biological external factors for animal and human body.
Any kind of damage which occurs on skin is named wound. Wounds can be mild such that the skin can repair itself in short duration; and in some cases, healing of the wounds may delay or may stop. In the art, wounds which are not healed within duration between 4-6 weeks are named non-healing or chronic wound. Various internal-sourced factors (factors which belong to the body of a person) or external-sourced factors can determine the healing duration of the wound.
Wound and skin infections mean that the tissues are infected by one or more kind of microorganisms. Said infections trigger the immune system of the body and they can lead to tissue damage and inflammation in the body and decelerate the healing process.
In the art, the reasons which avoid healing of the wound are diagnosed and these reasons are eliminated as much as possible and a suitable medium is provided for healing for treatment of wound and skin infections. The treatments for healing of the skin and wound infections can show variety in a range from usage of ointments, including antibiotics, to surgical operations depending on the intensity of the infections. In the art, creams, ointments, sprays, gels and disinfectants, which mostly include synthetic components, are used for the treatment of wound and skin infections. These creams hardly include herbal active substance or do not include any herbal active substance. Pharmaceutical compositions including a small number of herbal components can show small amount of synergic effect. Synthetic components (components which are obtained by means of chemical methods) can show side effects for some patients and can lead to an unfavorable condition because they can have a toxic effect. Because of such reasons, usage of herbal-based components which are ideal for skin and wound care and which are beneficial for health and which have high bio-availability increases every passing day in the related technical field.
Migraine is a kind of head ache which can affect daily life of a patient and which can lead to limitation in daily activities of the patient. In general, migraine begins in the periphery of back of the neck, temporal or eyes and can become denser depending on the type of the ache. Most of the time, sensitivity to light and sound, nausea and vomiting can accompany to the ache.
While various drugs, including synthetic components, can be used for treatment of migraine disease, pluralities of pharmaceutical compositions, including herbs like basil, lavender, mint and daisy, can also be used.
In the present art, pharmaceutical compositions are needed which include herbs at higher concentrations and which show favorable effect for the treatment in the course of the wound and skin infections, zoster and migraine diseases and which eliminate the side effects of the drugs having a chemical form.
As a result of the search made in the literature, the document with number TR2021/00190 can be shown as an example for the known state of the art. In said document, the invention relates to a drug which includes herbs and which is used in treatment of virus-sourced diseases like chronic sinusitis, influenza, herpes zoster, herpes simplex, corona virus and in treatment of liver lesions and reinforcement of the immune system and in prevention of reproduction of cancer cells and which is in nose drop, throat spray, pastille, soft gelatin capsule, cream and ointment form including powder mixture obtained by means of extraction and lyophilization method from the ecballium elaterium herb fruit, which is also known as fructus elateri, and foliages and stem and roots. As another example, the document with number TR2020/0156 can be shown. In this document, the invention relates to an herbal support cream which is easily applicable and which supports treatment and which eliminates inflammation and which heals wound and which has bitter gourd extract, oil, vaseline, stearic acid, alcohol, isopropyl myristate, glycerine and water ingredient.
As a result, in the related technical field, pharmaceutical compositions including herbal components are needed to be obtained which have antiviral, antibacterial, antifungal, antiinflammatory, analgesic characteristics and which shall not lead to any side effect or any toxic effect for human and animal body.
OBJECT OF THE INVENTION
The present invention relates to a cream including herbal ingredient in order to be used in prevention and treatment of wound and skin infections and migraine, arthritis and zoster diseases and in elimination of the symptoms which result from these diseases, for eliminating the abovementioned disadvantages and for bringing new advantages to the related technical field.
An object of the present invention is to obtain a cream including herbal component with high amounts and which does not comprise any side effect and any toxic effect for human and animal body.
An object of the present invention is to obtain a cream including herbal components which have antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
An object of the present invention is to obtain a cream including herbal ingredient and having high bio-availability.
In order to realize all of these objects, the present invention relates to a cream for use in treatment of wound and skin infections, arthritis, migraine and zoster diseases or in elimination of the symptoms which result from these diseases. The cream comprises powders, essence oils or mixtures thereof obtained by means of modern or traditional methods from fenugreeks which have antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics. In a possible embodiment of the invention, the subject matter cream comprises fenugreek at a value between 10% and 30% by weight.
In a possible embodiment of the invention, the subject matter cream comprises fenugreek at a value of 20% by weight.
In a possible embodiment of the invention, the subject matter cream comprises powders, essence oils or mixtures obtained by means of modern or traditional methods from black seed and fenugreek having antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
In a possible embodiment of the invention, the wound is acute wounds, chronic wounds, infectious wounds, abrasion wounds, tear wounds, bruise wounds, trauma wounds, knife wounds, skin cuts, surgical wounds, gun wounds, thermal wounds, chemical wounds, bites, stings and electrical-sourced wounds.
In a possible embodiment of the invention, the subject matter cream comprises at least one auxiliary substance.
In a possible embodiment of the invention, said auxiliary substance is selected from the group formed by solvents, lubricants, filling substances, density enhancers, oils, emollients, penetration enhancers, binders, dispensers and preservatives.
DETAILED DESCRIPTION OF THE INVENTION
In this detailed description, the subject matter relates to a cream including herbal components with antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics and which is suitable for use in prevention and treatment of wound and skin infections, arthritis, migraine and zoster diseases or in elimination of the symptoms which result from these diseases, and is explained with references to examples without forming any restrictive effect only in order to make the subject more understandable.
The subject matter cream has a structure which has high bio-availability and which shall show effect for long duration by long-duration release on the skin. The subject matter cream is applied to the region where skin integrity has been deteriorated, and treatment of skin and wound infections is realized (by laying or saturating). For the treatment of zoster and migraine, the subject matter cream can be applied by laying or saturating to the region where the ache is sensed.
The term “wound” used within the scope of the present invention describes acute wounds, chronic wounds, infectious wounds, abrasion wounds, tear wounds, bruise wounds, trauma wounds, knife wounds, skin cuts, surgical wounds, gun wounds, thermal wounds, chemical wounds, bites, stings and electrical-sourced wounds.
In order to meet all these characteristics, the subject matter cream comprises powder forms of the herb, known frequently as fenugreek in the related technical field and named as Trigonella foenum-graecum in Latin and named as Semen Foenugraeci in medicine, obtained by means of traditional drying methods or by application of extraction and lyophilization methods and essence oils of said herb obtained by means of traditional and/or modern essence oil obtaining methods.
As the essence oil obtaining methods mentioned here, traditional and modern distillation, extraction, cold compression and/or maceration methods can be used. The methods mentioned here do not limit the protection scope of the present invention.
The subject matter cream can comprise fenugreek in solid powder form in nano or micro dimensions if preferred.
Said fenugreek comprises high amount of proteins, minerals and vitamins. Besides, fenugreek comprises nitric compounds, phytin, choline, rutine, nicotine amid, coumarin, eholine, sentionine and cerpaine alkaloids, diosgenin, steroidal saponins and vitamins A, B and C. Since these and similar minerals, vitamins and various chemical compounds exist in fenugreek, it has been detected by the invention owner that fenugreek shows antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
In the treatment of wound and skin infections besides migraine and zoster diseases and in elimination of the symptoms which result from these diseases, fenugreek functions as the basic component in the invention because of its antiviral, antibacterial, antifungal, antiinflammatory, analgesic characteristics.
The subject matter cream comprises powder forms of the herb, known frequently as black seed in the related technical field and named as Nigella Steva in Latin, obtained by means of traditional drying methods or by application of extraction and lyophilization methods and essence oils of said herb obtained by means of traditional and/or modern essence oil obtaining methods.
The subject matter cream can comprise black seed in solid powder form in nano or micro dimensions if preferred.
Said black seed comprises quinone components like thymoquinone, thymohydroquinone, dithymoquinone at high ratios. Besides said compounds, black seed also comprises thymol, limonene, carvacrol, p-cymene, longipholene, t-anethole benzene compounds. Since black seed comprises these and similar minerals, vitamins and various chemical compounds; black seed is used in the subject matter cream as an agent which has antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
The subject matter cream comprises fenugreek, and besides, it comprises black seed which can form synergic effect with fenugreek thanks to the compounds included in its body.
The subject matter cream comprises fenugreek oils and/or powders at a value between 10% and 30% by weight.
The subject matter cream comprises fenugreek oils and/or powders at a value of 20% by weight.
The subject matter cream comprises powders, essence oils or mixtures obtained from black seed and fenugreek by means of modern or traditional methods. The invention owners expect a synergic effect related to increasing antiviral, antibacterial, antifungal, antiinflammatory, analgesic characteristics of the subject matter cream because these two components exist together. By means of providing synergic effect for the subject matter cream, high antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics are obtained and the subject matter cream can be used in prevention and treatment of wound and skin infections and migraine and zoster diseases and in elimination of the symptoms which result from these diseases.
The subject matter cream comprises the powders, essence oils or mixtures of black seed obtained by means of modern or traditional methods and/or the powders, essence oils or mixtures of fenugreek obtained by means of modern or traditional methods, and the obtained cream can be used as pharmaceutical composition. The subject matter cream is used as nutraceutical composition.
In another perspective, the subject matter cream can comprise at least one auxiliary substance. Said auxiliary substances can be substances which can contribute to providing cream characteristic to the cream and obtaining a stable structure and showing long duration effect. As example to these, said auxiliary substances can be selected from a group formed by solvents, lubricants, filling substances, density enhancers, oils, emollients, penetration enhancers, binders, dispensers and preservatives.
The invention owner has detected that by using a cream comprising powders, essence oils or mixtures of fenugreek and black seed obtained by means of modern or traditional methods, said wound and skin infections are more rapidly healed and the treatment duration is shortened and rapid epithelization of the damaged region is provided. Moreover, the cream, including powders, essence oils or mixtures obtained by means of modern or traditional methods from fenugreek and black seed which trigger healing in the wound and skin infection region and afterwards which show modulating characteristic for the immune elements which can prevent healing, is controlled in a manner providing healing of inflammation wounds.
The protection scope of the present invention is set forth in the annexed claims and cannot be restricted to the illustrative disclosures given above, under the detailed description. It is because a person skilled in the relevant art can obviously produce similar embodiments under the light of the foregoing disclosures, without departing from the main principles of the present invention.

Claims

1. The present invention is a cream for use in treatment of wound and skin infections, migraine, arthritis and zoster diseases or in elimination of the symptoms which result from these diseases, wherein the subject matter cream comprises powders, essence oils or mixtures thereof obtained by means of modern or traditional methods from fenugreek which have antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
2. The cream according to claim 1 , wherein the subject matter cream comprises fenugreek at a value between 10% and 30% by weight.
3. The cream according to claim 2, wherein the subject matter cream comprises fenugreek at a value of 20% by weight.
4. The cream according to any one of the claims 1 -3, wherein the subject matter cream comprises powders, essence oils or mixtures obtained by means of modern or traditional methods from black seed and fenugreek having antiviral, antibacterial, antifungal, anti-inflammatory, analgesic characteristics.
5. The cream according to any one of the claims 1 -4, wherein the wound is acute wounds, chronic wounds, infectious wounds, abrasion wounds, tear wounds, bruise wounds, trauma wounds, knife wounds, skin cuts, surgical wounds, gun wounds, thermal wounds, chemical wounds, bites, stings and electrical-sourced wounds.
6. The cream according to any one of the claims 1 -5, wherein the subject matter cream comprises at least one auxiliary substance.
7. The cream according to claim 6, wherein said auxiliary substance is selected from the group formed by solvents, lubricants, filling substances, density enhancers, oils, emollients, penetration enhancers, binders, dispensers and preservatives.
8. Usage of the cream, characterized according to claims 1 -7, as a nutraceutical composition for use in treatment of wound and skin infections, zoster and migraine diseases or in elimination of the symptoms which result from these diseases.
8 Usage of the cream, characterized according to claims 1 -8, as a pharmaceutical composition for use in treatment of wound and skin infections, zoster and migraine diseases or in elimination of the symptoms which result from these diseases.
9
PCT/TR2022/051077 2021-10-07 2022-10-03 A cream comprising fenugreek for prevention of zoster, wound and skin infections and for treatment of migraine, arthritis WO2023059298A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2021/015672 TR2021015672A2 (en) 2021-10-07 A CREAM CONTAINING HERBAL INGREDIENTS FOR PREVENTING SHINGLES, WOUNDS AND SKIN INFECTIONS AND TREATMENT OF MIGRAINE AND ARTHRITIS.
TR2021015672 2021-10-07

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WO2008125120A2 (en) * 2007-04-13 2008-10-23 V-Biotek Holding Aps Extract of trigonella foenum-graecum

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