WO2023056621A1 - Tube d'accès à un échantillon - Google Patents

Tube d'accès à un échantillon Download PDF

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Publication number
WO2023056621A1
WO2023056621A1 PCT/CN2021/122806 CN2021122806W WO2023056621A1 WO 2023056621 A1 WO2023056621 A1 WO 2023056621A1 CN 2021122806 W CN2021122806 W CN 2021122806W WO 2023056621 A1 WO2023056621 A1 WO 2023056621A1
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WO
WIPO (PCT)
Prior art keywords
tube
adapter
sample
tube body
drip
Prior art date
Application number
PCT/CN2021/122806
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English (en)
Chinese (zh)
Inventor
张力军
吴恒
Original Assignee
南京诺唯赞生物科技股份有限公司
南京诺唯赞医疗科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 南京诺唯赞生物科技股份有限公司, 南京诺唯赞医疗科技有限公司 filed Critical 南京诺唯赞生物科技股份有限公司
Priority to PCT/CN2021/122806 priority Critical patent/WO2023056621A1/fr
Publication of WO2023056621A1 publication Critical patent/WO2023056621A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • the application relates to the field of medical devices, in particular to a sample access tube.
  • the current preservation solution used to preserve viral nucleic acid samples is usually composed of a buffer supplemented with protein denaturants such as guanidine isothiocyanate, which has better preservation performance.
  • protein denaturants such as guanidine isothiocyanate
  • the flocked swab head after repeatedly scratching the subject's nose and pharynx is immersed in the sample preservation solution.
  • This provides a convenient, fast, safe and effective method for preserving viral nucleic acid on nasopharyngeal swabs, providing a reliable guarantee for high-quality nucleic acid templates required for detection and diagnosis, and can meet various molecular detection, diagnosis, and analysis Experimental requirements.
  • the current preservation tubes have certain defects, that is, a pipette needs to be used to transfer the sample preservation solution from the preservation tube to the nucleic acid extraction tube when performing molecular detection, diagnosis and analysis experiments.
  • the caps of the preservation tubes need to be opened prior to transfer.
  • the nozzle opening of the preservation tube is required to be sufficient to accommodate the insertion of the pipette tip into the preservation tube to absorb the sample preservation solution. This highly open sampling operation can easily cause sample contamination.
  • a preservation tube to store the sample preservation solution and using a pipette to transfer the sample preservation solution usually a maximum of 60 sample preservation solutions are processed per hour, which has problems such as low efficiency and complicated operation.
  • the purpose of the present application is to provide a sample access tube suitable for storing swab samples (which contain potential pathogens such as fungi, bacteria and viruses) collected from the nose and throat of subjects (such as people). Pick.
  • swab samples which contain potential pathogens such as fungi, bacteria and viruses
  • the operation of transferring the sample preservation solution is convenient and fast, and the sample contamination can also be avoided or reduced.
  • the application provides a sample access tube (such as drop type), which includes a tube body, an adapter and a cover, wherein the tube body has a deformable (including but not limited to elastic deformation and flexible deformation) part, and wherein the aptamer has a droplet part.
  • a sample access tube such as drop type
  • the tube body has a deformable (including but not limited to elastic deformation and flexible deformation) part
  • the aptamer has a droplet part.
  • the airtight connection between the tube body and the adapter body When the airtight connection between the tube body and the adapter body is closed, the airtight connection between the cover body and the adapter body is opened, and the tube body is turned upside down, when no external force acts on the deformable part of the tube body, the The sample preservation solution will not be discharged from the drip outlet of the aptamer by itself; when the deformable part of the tube is deformed under the action of external force, the sample preservation solution in the tube will drip out from the drip outlet of the aptamer.
  • a set number of liquid droplets drip out from the liquid drop outlet of the adapter, and each liquid droplet has a set volume value or range.
  • the present application provides a sample access tube (such as a drip type), which includes a tube body, an adapter and a cap, wherein the tube body has a deformable part and the adapter has a drip part.
  • a sample access tube such as a drip type
  • the tube body has a deformable part
  • the adapter has a drip part.
  • the airtight connection is a threaded connection.
  • the inner diameter of the drip outlet, drip channel and/or drip inlet of the drip portion is less than about 5.0, 4.9, 4.8, 4.7, 4.6, 4.5, 4.4, 4.3, 4.2, 4.1, 4.0, 3.9 , 3.8, 3.7, 3.6, 3.5, 3.4, 3.3, 3.2, 3.1, 3.0, 2.9, 2.8, 2.7, 2.6, 2.5, 2.4, 2.3, 2.2, 2.1, 2.0, 1.9, 1.8, 1.7, 1.6, 1.5, 1.4 , 1.3, 1.2, 1.1 or 1.0 mm, ⁇ 0.01, 0.02, 0.03, 0.04 or 0.05 mm.
  • the length of the drip channel of the drip portion is greater than about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 , 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42 , 43, 44, 45, 46, 47, 48, 49 or 50 mm, ⁇ 0.1, 0.2, 0.3, 0.4 or 0.5 mm.
  • a single maximum allowable deformation of the deformable portion results in about 1-600, 5-500, 10-400, 15-300, 20-200 or 25-100 microliters, such as about 1, 10, 20 ,30,40,50,60,70,80,90,100,110,120,130,140,150,160,170,180,190,200,210,220,230,240,250,260,270 ,280,290,300,310,320,330,340,350,360,370,380,390,400,410,420,430,440,450,460,470,480,490,500,510,520 , 530, 540, 550, 560, 570, 580, 590 or 600 microliters, ⁇ 1, 2, 3, 4 or 5 microliters of tube volume difference.
  • the airtight connection between the tube body and the adapter body when the airtight connection between the tube body and the adapter body is closed, the airtight connection between the cover body and the adapter body is opened, and the tube body is inverted, when no external force acts on the deformable body of the tube body Partially, the sample preservation liquid in the tube body will not be discharged from the drip outlet of the adapter body; The outlet drips out.
  • a single maximum allowable deformation of the deformable portion of the tube body is sufficient to cause N drops of the sample preservation solution to drip from the dripping portion of the aptamer but not enough to cause N+1 drops of the sample preservation solution to emerge from the aptamer Part of the dripping liquid drops out, optionally, N is an integer of 1 to 10, such as 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, optional 3 to 5, such as 3, 4 or 5.
  • the sample preservation solution in the tube is dripped from the drip outlet of the aptamer in a volume of about 1-100, 10-90, 20-80, 30-70 or 40-60 microliters , for example about 1, 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 microliters, ⁇ 1, 2, 3, 4 or 5 microliters.
  • (1) two sets of thread directions are the same, or, two sets of thread directions are the same and opposite; and/or (2) the number of threads between the pipe body and the fitting body is greater than that between the cap body and the fitting body number of threads; and/or (3) the thread density between the pipe body and the fitting body is greater than the thread density between the cover body and the fitting body; and/or (4) the thread density between the pipe body and the fitting body
  • the screwing resistance is greater than the thread screwing resistance between the cover body and the adapter; and/or (5) the thread between the pipe body and the adapter is a safety thread.
  • the sample access tube of the present application further comprises (1) hanging skirt; and/or (2) standing skirt; and/or (3) sealing pad; and/or (4) sealing protrusion; and/or (5) sealing ring; and/or (6) sealing skirt; and/or (7) arresting protrusion; and/or (8) wiping protrusion; and/or (9) connecting strip; and/or ( 10) Anti-slip structure.
  • the sample access tubes of the present application have the following characteristics: (1) capable of holding 1-10 swab heads and optionally a portion or the entire swab shaft; and/or (2) having about 0.5 - 3.0 cm inside diameter of the tube; and/or (3) having a tube body height of about 3-15 cm; and/or (4) having a tube body volume of about 1-50 ml; and/or (5) tube body
  • the airtight connection with the adapter cannot be opened after being closed; and/or (6) the airtight connection between the cover and the adapter can be opened and closed repeatedly; and/or (7) the tube body is partially or completely transparent or translucent.
  • the present application provides a method for using the sample access tube of the present application (such as a drip type) (such as accessing a swab sample), which includes one or more of the following steps:
  • the effect of the present application is at least that: without using a pipette, only by squeezing the deformable part of the tube body, the sample preservation solution stored in the sample access tube can be transferred quickly and effectively; Volume (depending on several factors, such as the inner diameter and shape of the drip outlet and the inclination angle of the drip channel) of sample preservation liquid; by controlling extrusion, a set number of droplets can be obtained; copies can be set; mixed samples can be set ; By limiting the exposure of the sample preservation solution to the outside world, the sample preservation solution can be safely transferred (this not only avoids or reduces the contamination of the sample preservation solution from the outside, but also avoids or reduces the spread of pathogens that may exist in the sample preservation solution to the outside world). This application also provides the possibility for the automation of the whole process of sample detection.
  • FIG. 1 is an embodiment of the sample access tube of the present application.
  • A Exploded view of the sample access tube;
  • B Schematic diagram of the assembled sample access tube;
  • Fig. 2 is an embodiment (i.e. embodiment 1) of the sample access tube of the present application.
  • FIG. 3 is a schematic structural view of various embodiments of the tube body of the sample access tube of the present application.
  • Fig. 4 is a structural schematic diagram of various embodiments of the adapter (and liquid outlet channel) of the sample access tube of the present application;
  • FIG. 5 is a schematic structural view of various embodiments of the cover of the sample access tube of the present application.
  • Fig. 6 is a structural schematic diagram of various embodiments of the drip outlet and part of the drip channel of the adapter of the sample access tube of the present application;
  • Fig. 7 is a schematic diagram of an embodiment of the aptamer of the sample access tube of the present application.
  • FIG. 8A is a schematic diagram of an embodiment of the tube body of the sample access tube of the present application.
  • Fig. 8B is a schematic diagram of an embodiment of the adapter of the sample access tube of the present application.
  • FIG. 8C is a schematic diagram of an embodiment of the cover of the sample access tube of the present application.
  • Figure 9 shows a schematic diagram of the measurement method for the drop inlet.
  • Tube body 11. Lower section of tube body; 12. Upper section of tube body; 13. Middle section of tube body; 14. Horizontal skirt; 15. Vertical skirt; 16. Deformable part;
  • Aptamer; 21 The lower part of the aptamer; 22. The upper part of the aptamer; 23. The middle part of the aptamer; 24. The junction between the lower part of the aptamer 21 and the middle part of the aptamer 23; 25.
  • Adaptation The connecting part between the upper part of the adapter body 22 and the middle part of the adapter body 23; 26, the blocking protrusion;
  • Cover body 31. Cover body main body; 32. Topping of cover body body; 33. Cover body lower section; 34. Joint between cover body main body 31 and cover body lower section 33.
  • a first feature being "on” or “under” a second feature may include direct contact between the first and second features, and may also include the first and second features Not in direct contact but through another characteristic contact between them.
  • “above”, “above” and “above” the first feature on the second feature include that the first feature is directly above and obliquely above the second feature, or simply means that the first feature is horizontally higher than the second feature.
  • “Below”, “beneath” and “under” the first feature to the second feature include that the first feature is directly below and obliquely below the second feature, or simply means that the first feature has a lower level than the second feature.
  • the present application provides a sample access tube (such as a drip type), which includes a tube body, an adapter and a cap, wherein the tube body has a deformable (including but not limited to elastic deformation and flexible deformation) portion , and wherein the aptamer has a droplet portion.
  • a sample access tube such as a drip type
  • the tube body has a deformable (including but not limited to elastic deformation and flexible deformation) portion
  • the aptamer has a droplet portion.
  • the airtight connection between the tube body and the adapter body When the airtight connection between the tube body and the adapter body is closed, the airtight connection between the cover body and the adapter body is opened, and the tube body is turned upside down, when no external force acts on the deformable part of the tube body, the The sample preservation solution will not be discharged from the drip outlet of the aptamer by itself; when the deformable part of the tube is deformed under the action of external force, the sample preservation solution in the tube will drip out from the drip outlet of the aptamer.
  • a set number of liquid droplets drip out from the liquid drop outlet of the adapter, and each liquid droplet has a set volume value or range.
  • the tube body includes a tube wall and a lumen surrounded by the tube wall.
  • the nozzle can be in any shape, such as circular, oval, square, rectangular, etc., circular is optional.
  • the bottom of the tube can be in any shape, such as flat bottom (can be any shape, such as circular, oval, square, rectangular, etc.), arc bottom (such as spherical bottom), pointed bottom (such as cone bottom) and the like.
  • the cross-section of the tube body can be in any shape, such as circular, oval, square, rectangular, shuttle-shaped, etc., and circular is optional.
  • the cross-sectional shape at different positions of the tube body is the same.
  • the cross-sectional shape of the tube body is different at different positions, such as a combination of a circle and a rectangle.
  • the cross-sectional shapes at different positions of the pipe body are the same but different in size, for example, they are all circular, the top is large and the bottom is small, the top is small and the bottom is large, the middle is small and both ends are large, the middle is large and both ends are small, etc.
  • the body is segmented (eg, 2, 3 or more segments), wherein each segment independently has the characteristics described above.
  • the change in cross-section is gradual.
  • the change in cross-section is abrupt.
  • mutational embodiments there is a junction between the two segments involved in the mutation.
  • the inner diameter of the nozzle is less than or equal to 3.0, 2.9, 2.8, 2.7, 2.6, 2.5, 2.4, 2.3, 2.2, 2.1, 2.0, 1.9, 1.8, 1.7, 1.6, 1.5, 1.4, 1.3, 1.2 , 1.1, 1.0, 0.9, 0.8, 0.7, 0.6, 0.5, 04, 0.3, 0.2, or 0.1 cm, and/or, greater than or equal to 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0 , 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 or 3.0 cm, floating up and down 0.01, 0.02, 0.03, 0.04 or 0.05 cm.
  • the transverse dimensions of the tube body and/or tube bottom allow for one or more (for example 1-10, for example 3-5, for example 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 ) swab head and optionally part or the entire swab shaft.
  • the inner diameter of the tube body and/or the tube bottom is less than or equal to 3.0, 2.9, 2.8, 2.7, 2.6, 2.5, 2.4, 2.3, 2.2, 2.1, 2.0, 1.9, 1.8, 1.7, 1.6, 1.5, 1.4, 1.3, 1.2, 1.1, 1.0, 0.9, 0.8, 0.7, 0.6, 0.5, 0.4, 0.3, 0.2 or 0.1 cm, and/or, greater than or equal to 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 or 3.0 cm, floating 0.01 , 0.02, 0.03, 0.04 or 0.05 cm.
  • the cross-sectional area of the tube body and/or the tube bottom is less than or equal to 5.0, 4.9, 4.8, 4.7, 4.6, 4.5, 4.4, 4.3, 4.2, 4.1, 4.0, 3.9, 3.8, 3.7, 3.6, 3.5, 3.4, 3.3, 3.2, 3.1, 3.0, 2.9, 2.8, 2.7, 2.6, 2.5, 2.4, 2.3, 2.2, 2.1, 2.0, 1.9, 1.8, 1.7, 1.6, 1.5, 1.4, 1.3, 1.2, 1.1, 1.0, 0.9, 0.8, 0.7, 0.6, 0.5, 0.4, 0.3, 0.2, or 0.1 cm2, and/or, greater than or equal to 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1 , 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4,
  • the height of the tube body is 3-15 cm, such as 5-10 cm, such as 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15 cm, up and down Float 0.1, 0.2, 0.3, 0.4 or 0.5 cm.
  • the tube is capable of holding one or more (eg 1-10, eg 3-5, eg 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10) wipes Swab head and optional part or entire swab shaft.
  • the volume of the tube body is 1-50 milliliters, such as 3-20 or 5-15 milliliters, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 , 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37 , 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or 50 ml, plus or minus 0.1, 0.2, 0.3, 0.4 or 0.5 ml, where applicable.
  • the tube body contains 1-10 ml, such as 3-5 ml, such as 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 ml of sample preservation solution, floating up and down by 0.1, 0.2 , 0.3, 0.4 or 0.5 ml.
  • the deformable part of the tube body can still undergo a set maximum allowable deformation under the action of an external force.
  • the tube bodies can be made of the same or different materials.
  • the tube body may include one section or one piece (or multiple sections or pieces) of rigid (non-deformable) walls, which can be used for affixing labels (such as two-dimensional codes), so as to mark samples and avoid sample confusion.
  • the tube body may include one or one (or multiple segments or pieces) soft (deformable, including but not limited to elastic deformation and flexible deformation) walls, which can be used to achieve volume changes of the tube body.
  • the whole or part of the tube body is made of transparent or translucent material, so as to observe whether there is a sample preservation solution in the tube body and judge its volume.
  • a volume scale is provided on the tube body, so as to judge the volume of the sample preservation solution in the tube body.
  • Deformation includes, but is not limited to, elastic deformation and flexible deformation.
  • elastic deformation is able to return to its original shape after the external force is removed.
  • the flexible deformation can also return to its original state by itself after the tube body is restored to its upright position, especially in the case of retaining a sufficient volume of sample preservation solution; or, the flexible deformation can be restored to its original state with the help of external force or a reset auxiliary device.
  • the tube body is deformable in whole or in part.
  • one or more sections of the tubular body are deformable, such as the lower section, the middle section or the upper section of the tubular body ("upper” is defined as the top of the tube, and “lower” is defined as the bottom of the tube).
  • one or more pieces (eg 2 pieces, especially symmetrical 2 pieces) of the tube body are deformable, such as deformable windows on the tube body.
  • the deformable portion may be of any shape, such as circular, oval, square, rectangular, etc. or combinations thereof.
  • the base of the tube and the optional connected portion of the tube body are deformable.
  • the deformable portion may be of any shape, such as a sphere or part thereof (e.g., spherical cap, spherical band), an ellipsoid or part thereof (eg, ellipsoidal cap, ellipsoidal band), cube, cuboid, etc., or its combination.
  • a sphere or part thereof e.g., spherical cap, spherical band
  • an ellipsoid or part thereof eg, ellipsoidal cap, ellipsoidal band
  • cube cuboid, etc., or its combination.
  • the deformable parts are carefully designed, calculated and tested.
  • the single maximum allowable deformation of the deformable part (based on calculation or practical operation) is enough to cause N drops of the sample preservation solution with a set volume value or range are dripped from the drip outlet of the aptamer but not enough to cause N+1 drops of the sample preservation solution to drip from the drip outlet of the aptamer.
  • N is 1 to 10 drops, eg 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 drops.
  • the set volume value is about 1-100, 10-90, 20-80, 30-70 or 40-60 microliters, such as about 1, 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 microliters, plus or minus 1, 2, 3, 4 or 5 microliters.
  • the set volume range is 1-25 microliters independently above and below the set volume value, such as about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 or 25 microliters.
  • the upper limit of the set volume range is about 1-25 microliters independently of one of the above-mentioned set volume values, such as about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 , 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 microliters.
  • the lower limit of the set volume range is about 1-25 microliters independently of one of the above set volume values, such as about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 , 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 microliters.
  • the maximum allowable deformation of the deformable portion results in a volume difference of about 1-600, 5-500, 10-400, 15-300, 20-200 or 25-100 microliters, for example about 1 ,10,20,30,40,50,60,70,80,90,100,110,120,130,140,150,160,170,180,190,200,210,220,230,240,250 ,260,270,280,290,300,310,320,330,340,350,360,370,380,390,400,410,420,430,440,450,460,470,480,490,500 , 510, 520, 530, 540, 550, 560, 570, 580, 590 or 600 microliters, plus or minus 1, 2, 3, 4 or 5 microliters.
  • the outer wall of the deformable part is provided with an anti-slip structure, which may be any structure that can play an anti-slip function, such as straight lines, curved lines, or particles.
  • the aptamer is in the form of a multilayer (eg, two, three or more layers) tower.
  • the lower layer of the aptamer is airtightly connected with the tube body
  • the upper layer of the aptamer is airtightly connected with the cover body
  • one or more intermediate layers connect the upper layer of the aptamer and the lower layer of the aptamer.
  • Each layer of the aptamer can independently be a cylinder or a truncated cone.
  • the cross-section of the outer wall and/or inner wall of each layer of the aptamer can independently be in any shape, such as circular, oval, square, rectangular, etc., and circular is optional.
  • the cross-sectional shapes at different positions of the outer wall and/or inner wall of each layer of the aptamer are the same.
  • the cross-sectional shapes of different positions of the outer wall and/or inner wall of each layer of the aptamer are different.
  • the cross-sectional shapes of different positions of the outer wall and/or inner wall of each layer of the aptamer are the same but different in size, for example, they are all circular, with a big top and a small bottom, a small top and a big bottom, a small middle and two big ends, and a middle Large and small at both ends, etc.
  • the inner wall of the connecting portion connected to the lower layer has a sealing skirt, which clamps the pipe body together with the lower layer wall.
  • the outer wall of the aptamer (such as the upper layer and/or the second upper layer and/or the second upper layer, and so on) is provided with a non-slip structure, which can be linear stripes, curved stripes, particles, etc. structure for easy tightening or unscrewing of the adapter.
  • the outer wall of the lower layer of the aptamer ie the layer that is airtightly connected with the tube body
  • a non-slip structure is provided with a non-slip structure.
  • the inner wall of the aptamer forms a liquid outlet channel.
  • the cross-sectional area of the outlet channel gradually increases from top to bottom.
  • the cross-sectional dimensions of the outlet channels of each layer are the same or have no significant change, for example, the difference between the largest diameter and the smallest diameter is no more than 25%, 20%, 15%, 10%, 9%, or less than the smallest diameter. 8%, 7%, 6%, 5%, 4%, 3%, 2% or 1%.
  • the cross-sectional area of the liquid outlet channel corresponding to the interface between the various layers of the aptamer gradually decreases upwards, so that a funnel effect is generated when the aptamer is inverted, which is beneficial to the collection of the sample preservation solution.
  • the liquid outlet channel (especially the middle layer, if present) has a waist structure (such as a "tip-to-tip” double funnel-shaped channel) on the inner wall, which is used to buffer or weaken the rapid reversal.
  • a waist structure such as a "tip-to-tip” double funnel-shaped channel
  • the longitudinal section of the waist setting is triangular, rectangular or arc-shaped. This buffering effect can also be achieved by gradually or stepwise shrinking the outlet channel.
  • the tip of the aptamer is the drop outlet.
  • the drip outlet is usually round.
  • the part of the liquid outlet channel connected to the drip outlet is the drip channel (usually the upper layer of the aptamer, the joint part connected to it optionally, even the next layer, until the liquid outlet channel of the lower layer of the aptamer, or its connection part of the drip outlet).
  • the other end of the drip channel is a drip inlet.
  • the dripping outlet, the dripping channel and the dripping inlet constitute the dripping part.
  • the dripping channel is the whole or part of the liquid outlet channel (that is, the part connected to the dripping outlet).
  • the drip outlet and/or the drip channel and/or the drip inlet have suitable internal diameters, which are independently arranged to: close the tight connection between the tube body and the adapter, open the tight connection between the lid and the adapter When the connection and the tube body are upside down, when there is no external force acting on the deformable part of the tube body, the sample preservation solution in the tube body will not be discharged from the drip outlet or even enter the drip channel; When the deformed part is deformed under the action of external force, the sample preservation liquid in the tube enters the dripping channel and drips out from the dripping outlet (drops with a set volume value or range can be optionally dropped).
  • the drip outlet and/or the drip channel and/or the drip inlet independently have an 3.8, 3.7, 3.6, 3.5, 3.4, 3.3, 3.2, 3.1, 3.0, 2.9, 2.8, 2.7, 2.6, 2.5, 2.4, 2.3, 2.2, 2.1, 2.0, 1.9, 1.8, 1.7, 1.6, 1.5, 1.4, 1.3, 1.2, 1.1 or 1.0 mm, and/or, greater than or equal to 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9 or 5.0 mm inner diameter, up and down Float 0.02, 0.02, 0.03, 0.
  • the cross-sectional dimensions of the dripping channel are the same or have no significant change, for example, the difference between the largest diameter and the smallest diameter is no more than 25%, 20%, 15%, 10%, 9%, 8%, or less than the smallest diameter. 7%, 6%, 5%, 4%, 3%, 2% or 1%.
  • the drip channel gradually narrows upwards, and the difference between the largest diameter and the smallest diameter is no more than 25%, 20%, 25%, 10%, 9%, 8%, 7%, 6%, 5% of the smallest diameter. %, 4%, 3%, 2% or 1%.
  • the cross-sectional shapes of different positions of the dripping channel are the same but different in size, for example, they are all circular, with a big top and a small bottom, a small top and a big bottom, a small middle and two big ends, a big middle and two small ends, etc. ( Take the top of the cover as “up” and the bottom of the tube as “down”).
  • the length of the drip channel is less than or equal to 50, 49, 48, 47, 46, 45, 44, 43, 42, 41, 40, 39, 38, 37, 36, 35, 34, 33, 32, 31, 30, 29, 28, 27, 26, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3, 2 or 1 mm, and/or, greater than or equal to 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or 50 mm, up and down 0.1, 0.2, 0.3, 0.4 or 0.5 mm.
  • the drip outlet produces about 1-100, 10-90, 20-80, 30-70, or 40-60 microliters, such as about 1, 10, 20, 30, 40, 50, 60, 70 , 80, 90 or 100 droplets of a set volume range, floating 1, 2, 3, 4 or 5 microliters up and down.
  • the tip of the aptamer is pointed, flat or rounded/arc.
  • the cover body is closed and the other end is open.
  • the closed end is a cover top
  • the open end is a cover opening
  • the cover body is between the cover top and the cover opening.
  • the cover body includes a cover wall and a cover cavity surrounded by the cover wall.
  • the lid opening can be in any shape, such as circle, ellipse, square, rectangle, etc., and circle is optional.
  • Cover top can be any shape, for example flat top (can be any shape, for example circle, ellipse, square, rectangle etc.), arc top (for example ball top), pointed top (for example cone top) etc.
  • the body cross section can be any shape, such as circle, ellipse, square, rectangle etc., optional circle.
  • the cross-sectional shape of the body is the same at different locations.
  • the cross-sectional shape is different at different locations on the body.
  • the cross-sectional shapes of different positions of the cover body are the same but different in size, for example, they are all circular, the top is large and the bottom is small, the top is small and the bottom is large, the middle is small and the two ends are large, the middle is large and the two ends are small, and so on.
  • the cover body is segmented, wherein each segment independently has the characteristics described above.
  • the change in cross-section is gradual.
  • the change in cross-section is abrupt.
  • mutational embodiments there is a junction between the two segments involved in the mutation.
  • the cover is cylindrical, frustoconical or conical (for the upper layer) in shape.
  • the lid is hermetically attached to the upper layer of the aptamer.
  • the cap covers (completely or partially) the upper layer of the aptamer.
  • the cover has a flap which completely or partially covers the junction with the upper layer of the adapter.
  • the cover is a multi-layer (eg, two-layer) tower-like configuration, wherein each layer is independently a cylindrical, frustoconical, or conical (for the upper layer) configuration.
  • the upper layer of the cap is hermetically fitted to the upper layer of the aptamer.
  • the upper layer of the cover completely covers the upper layer of the aptamer, and the layers of the cover other than the upper layer in turn (completely or partially) cover the layers of the aptamer except the upper layer. These can avoid or reduce the operator's hand contact with the sample and avoid or reduce contamination. In any case, the top of the cap seals the adapter's drip outlet.
  • the outer wall of the cover (for example, the upper layer and/or the second upper layer and/or the second upper layer, etc.) is provided with an anti-slip structure, which is convenient for screwing or unscrewing the cover.
  • the outer wall of the upper layer of the cover body and/or the second upper layer is provided with a non-slip structure.
  • the inner wall of the roof has sealing protrusions.
  • the outer wall of the sealing protrusion can be in sealing fit with the inner wall of the section where the dripping channel is connected to the dripping outlet.
  • the airtight connection between the various components of the sample access tube of the present application i.e., the tube body, the adapter body and the cover body
  • the airtight connection between the tube body and the adapter body and the connection between the cover body and the adapter body. closed connection is, the airtight connection between the tube body and the adapter body and the connection between the cover body and the adapter body. closed connection.
  • Connections can be reversible (ie, can be opened and closed repeatedly) or irreversible (ie, cannot be opened and closed repeatedly).
  • the connection between the tube body and the adapter is irreversible, ie it cannot be opened again after being closed.
  • the advantage is to avoid sample contamination caused by related misoperations. This requires tubes and adapters to be provided separately when storing samples.
  • the connection between the lid and the aptamer is reversible, ie it can be opened and closed repeatedly. The advantage is that it is convenient to review samples.
  • connection methods in the related art may be used, such as slots, buckles, threads, and the like.
  • the connection method is threaded connection (screwed connection for short).
  • screw connection screwed connection for short.
  • the directions of the two sets of threads can be the same or opposite.
  • the numbers of two sets of threads can be the same or different, for example, the number of threads between the pipe body and the adapter body is more or less.
  • the number of threads between the cover body and the fitting body is less than the number of threads between the tube body and the fitting body.
  • the densities of the two sets of threads can be the same or different, for example, the thread density between the pipe body and the adapter body is greater or lesser.
  • the thread density between the cover body and the fitting body is smaller than the thread density between the pipe body and the fitting body. This can avoid or reduce the risk of related mishandling to open the tight connection between the tube body and the adapter body.
  • the opening resistance of the connection between the cap body and the adapter body is lower than that between the tube body and the adapter body.
  • connection opening resistance can be set by carefully setting the gap between the contact surfaces and the thickness of the thread, as well as by using specific materials.
  • the screw connection between the tube body and the adapter body may adopt child safety threads, such as pressing down the rotating thread, pressing the rotating thread or aligning the rotating thread. To ensure a tight seal, screw connections can be combined with gaskets or rings.
  • the adapter body When the tube body is airtightly connected with the adapter body, the adapter body covers the upper opening of the tube body (that is, the nozzle). At this time, the inner cavity of the tube body communicates with the liquid outlet channel of the aptamer, and the sample preservation liquid in the inner cavity of the tube can and can only flow out through the liquid outlet channel of the aptamer.
  • the cover body When the cover body is airtightly connected with the adapter body, the cover body covers the upper end opening (that is, the drop outlet) of the adapter body. At this time, the drip outlet of the aptamer is sealed, and the sample preservation solution in the liquid outlet channel of the aptamer and/or the inner cavity of the tube body cannot flow out through the drip outlet of the aptamer.
  • the sample access tube of the present application may also have auxiliary elements/structures for realizing auxiliary functions.
  • the sample access tube of the present application has a blocking protrusion or a blocking net, which is used to block the swab head and/or swab rod from entering and blocking the downstream liquid outlet channel and/or drip outlet when the tube body is inverted .
  • the arresting protrusion or arresting net can be located at any position of the liquid outlet channel, including the inlet and outlet of the liquid outlet channel (ie, the drip outlet).
  • the liquid outlet channel (including the drip outlet) has one or more (for example, 4, 6 or 8) blocking protrusions arranged on the inner wall.
  • the arresting protrusions can be evenly distributed along the circumference and arranged in a cross shape or a rice font. The size and arrangement of the arresting protrusions are such that the swab head and/or the swab shaft cannot pass through the gaps between the respective arresting protrusions.
  • the sample access tube of the present application has a transverse skirt (ie, extends outward from the body in a horizontal or approximately horizontal direction).
  • transverse skirts can be provided on various parts of the tubular body or adapter body.
  • the horizontal skirt can be used to realize the suspension of the sample access tube on the tube rack.
  • the sample access tube of the present application has a vertical skirt (ie, extends downward from the body in a vertical or near-vertical direction).
  • Vertical skirts are usually provided on the pipe body, especially around the bottom of the pipe. The vertical skirt can be used to realize the standing of the sample access tube on the table.
  • the sample access tube of the present application has a sealing gasket (for example, for the cover, for example, for strengthening the seal of the cover to the adapter), a sealing protrusion (for example, for the cover, for example, for strengthening cover to the fitting body), sealing ring (such as for the fitting body, such as for strengthening the sealing of the fitting body to the Ligand to the sealing of the tube body), used to realize or enhance the airtight connection between the cover body and the adapter and/or the airtight connection between the tube body and the adapter and/or the sealing during the above-mentioned airtight connection (for example Seal to drip outlet).
  • a sealing gasket for example, for the cover, for example, for strengthening the seal of the cover to the adapter
  • a sealing protrusion for example, for the cover, for example, for strengthening cover to the fitting body
  • sealing ring such as for the fitting body, such as for strengthening the sealing of the fitting body to the Ligand to the sealing of the tube body
  • there is a connecting band between the tube body and the adapter of the sample access tube of the present application which is used to prevent the adapter (optionally together with cover) onto the table or floor, reducing the risk of contamination.
  • there may be a connecting band between the cover and the adapter of the sample access tube of the present application which is used to prevent the cover from falling off the desktop or the ground when the airtight connection between the cover and the adapter is opened, thereby Reduce the risk of contamination.
  • there may be a connecting band between the cover and the tube of the sample access tube of the present application which is used to prevent the cover from falling on the desktop or the ground when the airtight connection between the cover and the adapter is opened, thereby reducing the pollution risk.
  • the sample access tube of the present application has a wiper protrusion.
  • the inner wall of the tube body has multiple (for example 4, 6, 8 or 12) centripetal protrusions evenly distributed along the circumference, or there are multiple (for example 4, 12) uniformly distributed at the bottom of the tube 6, 8 or 12) protrude upwards, and the swab head rubs against the protrusions when moving up and down at this position, which is beneficial for the body fluid attached to the swab head to mix with the sample preservation solution.
  • the swab head may not be stored.
  • the sample access tube of the present application has a volume adjustment member, which is used to adjust the volume of the inner cavity of the sample access tube, which helps to realize the formation and detachment of droplets at the drip outlet.
  • the adjustment is stepwise, eg linear or non-linear.
  • isometric bellows-like structures can be used to achieve linear stepwise regulation.
  • expanding concentric circular bellows-like structures can be used to realize nonlinear step-by-step regulation.
  • the volume adjusting member can be arranged on the bottom of the tube or on the wall of the tube.
  • the volume adjustment means provides greater than or equal to 5%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60% of the set volume value or range median value of the droplet , 70%, 80%, 90% or 100% and/or less than or equal to 100%, 90%, 80%, 70%, 60%, 50%, 40%, 30%, 25%, 20%, 15%, 10% or 5% volume adjustment capability.
  • the sample access tube of the present application has a non-slip structure.
  • the anti-slip structure can be provided on various parts of the sample access tube, namely the cover and/or the adapter and/or the tube, or parts thereof, such as the middle or upper section of the tube, the lower layer of the adapter, and the upper layer of the cover Or the next upper layer, such as the deformable part of the pipe body.
  • the anti-skid structure can be any structure that can play a role in anti-skid, such as straight stripes, curved stripes, and particles.
  • sample access tubes of the present application and their individual elements (ie, the tube body (except the deformable portion), the adapter body and the cap body, and various parts thereof) are made of rigid materials.
  • the tube body of the sample access tube of the present application has a deformable (including but not limited to elastic deformation and flexible deformation) part. Deformation may be achieved through deformable materials and/or structures.
  • the sample access tube of the present application and its various elements can be made of any suitable material in the related art, especially medical plastics, such as polyethylene ( PE, including low-density polyethylene and high-density polyethylene), polypropylene (PP), polypropylene (PPE), polybutene, acrylonitrile butadiene styrene copolymer (ABS), styrene acrylonitrile, etc., and A modified material of the aforementioned material.
  • PE polyethylene
  • PP polypropylene
  • PPE polypropylene
  • ABS acrylonitrile butadiene styrene copolymer
  • ABS acrylonitrile butadiene styrene copolymer
  • styrene acrylonitrile etc.
  • the various components of the sample access tube ie, the tube body, the adapter, and the cap, and parts thereof
  • the pipe body (or parts thereof, independently of each other) can be made of low density polyethylene (LDPE), linear low density polyethylene (LLDPE), high density polyethylene (HDPE), 2,2,2,2-tetraphenylene Made of ethylene (TPE), etc. or a combination thereof.
  • aptamers (or parts thereof, independently of each other) may be made of, or may be coated with, a hydrophobic material, such as a fluoropolymer such as polytetrafluoroethylene.
  • the cover body (or parts thereof, independently of each other) can be made of high-density polyethylene (HDPE), polypropylene (PP), acrylonitrile-butadiene-styrene copolymer (ABS), polyethylene (PE), etc. or its composition.
  • the cover is made of polypropylene (PP).
  • the aptamer is made of polypropylene (PP).
  • the tube body is made of thermoplastic elastomer (TPE).
  • the deformable portion of the tube body is made of thermoplastic elastomer (TPE).
  • the sample access tube of the present application and its various components can be formed by any molding method in the related art, including but not limited to injection molding, blow molding or its combination.
  • the tube body, the adapter body and the cap body are sterilized and sterilized separately, or sterilized after being assembled.
  • the present application provides a method for using the sample access tube of the present application (such as a drip type) (such as accessing a swab sample), which includes one or more of the following steps:
  • Preparation close the airtight connection between the lid and the adapter, and distribute a predetermined volume (for example, 1-10 milliliters, such as 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 ml) of sample storage buffer, close the airtight connection between the tube body and the aptamer (together with the cap);
  • a predetermined volume for example, 1-10 milliliters, such as 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 ml
  • Deformation at which point the sample preservation solution within the tube exits as a droplet and falls into the sample collection container or its compartments
  • one compartment acquires one drop and one sample occupies one compartment; Or, get one drop from one compartment, and one sample replicate occupies multiple compartments; or get multiple drops from one compartment, and one sample occupies a single compartment; or, get multiple drops from one compartment, and one sample replicates alone, Occupy multiple compartments; or, take multiple drops from one compartment, and multiple samples share one compartment, one drop per sample; or, take multiple drops from one compartment, and multiple samples share one compartment, one sample Multiple drops; or, multiple drops from one compartment, multiple samples occupying multiple compartments, one drop per sample; or, multiple drops from one compartment, multiple samples occupying multiple compartments, one multiple drops of sample); after the sampling is finished, restore the airtight connection between the cap and the adapter (together with the tube).
  • one drop is about 15-20 microliters.
  • three drops are harvested per compartment.
  • This embodiment depicts an example of a sample access tube. As shown in FIG. 2 , this embodiment provides a sample access tube, which includes a tube body 1 , an adapter body 2 and a cover body 3 .
  • the tube body 1 is a cylindrical tubular structure with one end closed and one end open.
  • the pipe body 1 includes a pipe body lower section 11 , a pipe body middle section 13 and a pipe body upper section 12 .
  • the lower section 11 of the pipe body is a bottom cover and a hollow cylinder.
  • the middle section 13 of the pipe body is a hollow cylinder made of elastic material capable of elastic deformation.
  • the upper section 12 of the pipe body is a hollow cylinder with threads on the outer wall, which is used for airtight screw connection with the lower section 21 of the adapter body.
  • Aptamer 2 is a hollow three-layer tower structure.
  • the aptamer 2 includes an aptamer lower section 21 , an aptamer middle section 23 and an aptamer upper section 22 .
  • the lower section 21 of the adapter body is a hollow cylinder with threads on the inner wall, and is used for airtight screw connection with the upper section 12 of the pipe body.
  • the outer wall of the lower section 21 of the aptamer has non-slip vertical lines.
  • the upper section 22 of the adapter body is a hollow cylinder with threads on the outer wall for airtight screw connection with the main body 31 of the cover body.
  • the aptamer middle section 23 connects the aptamer lower section 21 and the aptamer upper section 22 .
  • the cover body 3 is a two-layer tower structure with one end closed and one end open.
  • the cover body 3 includes a cover body body 31 and a cover body lower section 33 .
  • the cover main body 31 is a capped, hollow cylinder with threads on the inner wall for airtight screw connection with the upper section 22 of the adapter body.
  • the cover body 31 has a cap 32 .
  • the lower section 33 of the cover body is a hollow cylinder for contacting the middle section 23 of the adapter body.
  • the adapter body 2 When the adapter body 2 is tightly screwed with the pipe body 1 , the adapter body 2 (partially) covers the top opening of the pipe body 1 . Specifically, when the lower part 21 of the fitting body is tightly screwed with the upper part 12 of the tubular body, the connecting part 24 between the lower part 21 of the fitting body and the middle part 23 of the fitting body covers (partially) the top opening of the upper part 12 of the tubular body. At this time, the inner cavity of the tube body 1 communicates with the outlet channel of the aptamer 2, and the solution in the inner cavity of the tube can only flow out through the outlet channel of the aptamer.
  • the cover body 3 When the cover body 3 and the adapter body 2 are airtightly screwed, the cover body 3 (completely) covers the top opening of the adapter body 2 . Specifically, when the cover body 31 is airtightly screwed to the upper part of the fitting body 22 , the capping 32 of the cover body 31 (completely) covers the top opening of the upper part of the fitting body 22 . At this time, the top opening of the aptamer liquid outlet channel is sealed, and the solution in the aptamer liquid outlet channel and/or the inner cavity of the tube cannot flow out through the top opening of the upper section 22 of the aptamer.
  • the middle section 13 of the pipe body is made of elastic material and can be elastically deformed.
  • the deformation of the middle section 13 of the tube body causes the solution in the tube body to be discharged through the top opening of the upper section 22 of the aptamer.
  • This example describes the use of the sample access tube.
  • Nasopharyngeal swabs were obtained by repeatedly rubbing the subject's nasopharynx with the swab head of a sterilized flocked swab.
  • This embodiment depicts an example of a sample access tube.
  • the aptamer is shown in Figure 7.
  • the tube body is shown in Figure 8A.
  • This embodiment depicts an example of a sample access tube.
  • the tube, adapter and cap are shown in Figures 8A, 8B and 8C, respectively.
  • This embodiment depicts two examples of sample access tubes.
  • the tube, adapter and cap are substantially as shown in Figures 8A, 8B and 8C, respectively.
  • Only the inner diameter of the drip inlet is 2.44mm or 2.36mm (the measurement method is shown in Figure 9).

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hydrology & Water Resources (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

La présente invention concerne un tube d'accès à un échantillon, comprenant un corps de tube, un corps d'adaptation et un corps de couvercle. Le corps du tube est doté d'une partie déformable, et le corps d'adaptation est doté d'une partie d'égouttage de liquide. Lorsque le corps du tube est en position de séparation fermée par rapport au corps d'adaptation, que le corps du couvercle est en position de fermeture par rapport au corps d'adaptation, que le corps du tube est inversé et qu'aucune force externe n'agit sur la partie déformable du corps du tube, un liquide de conservation d'échantillon dans le corps du tube ne peut pas être automatiquement évacué d'une sortie d'égouttage de liquide du corps d'adaptation ; et lorsque la partie déformable du corps du tube se déforme sous l'action d'une force externe, le liquide de conservation d'échantillon dans le corps du tube est évacué par la sortie d'égouttage de liquide du corps d'adaptation. Facultativement, lorsque la partie déformable du corps du tube présente une déformation maximale admissible, le nombre défini de gouttelettes s'égoutte par la sortie d'égouttage de liquide du corps d'adaptation, et la valeur ou la plage de volume de chaque gouttelette est définie.
PCT/CN2021/122806 2021-10-09 2021-10-09 Tube d'accès à un échantillon WO2023056621A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2021/122806 WO2023056621A1 (fr) 2021-10-09 2021-10-09 Tube d'accès à un échantillon

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2021/122806 WO2023056621A1 (fr) 2021-10-09 2021-10-09 Tube d'accès à un échantillon

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WO2023056621A1 true WO2023056621A1 (fr) 2023-04-13

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050106753A1 (en) * 2003-07-11 2005-05-19 Oakville Trading Hong Kong Limited Sanitary fluid collection, application and storage device and methods of use of same
CN203388890U (zh) * 2013-07-12 2014-01-15 苏州发士达生物科技有限公司 肛拭子采样器
US10898169B1 (en) * 2020-10-13 2021-01-26 Forward Industries, Inc. Sputum collection and washing apparatus and a method of using it
CN212780851U (zh) * 2020-10-22 2021-03-23 厦门市云鹏科技发展有限公司 一种兼具采样和加样的采样管

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050106753A1 (en) * 2003-07-11 2005-05-19 Oakville Trading Hong Kong Limited Sanitary fluid collection, application and storage device and methods of use of same
CN203388890U (zh) * 2013-07-12 2014-01-15 苏州发士达生物科技有限公司 肛拭子采样器
US10898169B1 (en) * 2020-10-13 2021-01-26 Forward Industries, Inc. Sputum collection and washing apparatus and a method of using it
CN212780851U (zh) * 2020-10-22 2021-03-23 厦门市云鹏科技发展有限公司 一种兼具采样和加样的采样管

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