WO2023052995A1 - Compositions à haute teneur en urée et méthodes de renforcement d'agents actifs - Google Patents

Compositions à haute teneur en urée et méthodes de renforcement d'agents actifs Download PDF

Info

Publication number
WO2023052995A1
WO2023052995A1 PCT/IB2022/059185 IB2022059185W WO2023052995A1 WO 2023052995 A1 WO2023052995 A1 WO 2023052995A1 IB 2022059185 W IB2022059185 W IB 2022059185W WO 2023052995 A1 WO2023052995 A1 WO 2023052995A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
skin conditioning
skin
conditioning composition
weight
Prior art date
Application number
PCT/IB2022/059185
Other languages
English (en)
Inventor
Rebecca Chen
Yixin Yang
Original Assignee
L'oreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR2113556A external-priority patent/FR3130145A1/fr
Priority claimed from FR2113553A external-priority patent/FR3130147A1/fr
Application filed by L'oreal filed Critical L'oreal
Publication of WO2023052995A1 publication Critical patent/WO2023052995A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/884—Sequential application

Definitions

  • compositions for topical application to keratinous tissue, particularly compositions that include urea in high amounts, and compositions that include urea in high amounts together with actives for which the urea may provide stabilization and or boosted efficacy.
  • BACKGROUND Many cosmetic compositions are provided with select actives that provide any number of benefits, for example, including, but not limited to, skin desquamation (peeling).
  • Urea is a commonly used ingredient as a humectant.
  • High concentrations of urea for skin care are desirable for the humectant properties, including as a means to promote the stratum corneum to swell, and for stimulating skin desquamation.
  • Urea is found in many compositions that include other skin actives.
  • Various compositions that may include high concentrations of urea for skin care are thus desirable for the humectant properties.
  • Such skin care compositions would beneficially include urea or a derivative thereof in a range from about 20% to 40% by weight of the composition.
  • topical preparations that contain high concentrations of urea present many challenges
  • One challenge relates to the tendency of urea to undergo a continuous hydrolysis reaction that leads to pH increase, which can result in an increase from a pH of about 7 up to a pH of 9 or greater over the course of storage.
  • Such pH values at or greater than a pH of 8 are much higher than that of the natural skin, which is about 5.5, and compositions with a pH in this range would likely cause skin irritation when applied.
  • Such high resultant pH renders most formulations unsuitable for use on skin, particularly in water-based compositions which don’t provide protection through barrier forming oils and butters. This is particularly an issue for water-based leave-on compositions.
  • Yet another challenge is the tendency of urea to crystalize at high concentrations and at low temperature over time. This crystallization would be expected to reduce the amount of active urea available in the usable composition, thus diminishing the overall desired efficacy of the product.
  • a further challenge with high urea content is whitening of the skin which is not aesthetically pleasing to many consumers.
  • the inventors provide here a cosmetic skin care composition comprising a skin conditioning composition that is used in some embodiments for skin rejuvenation that includes use of the skin conditioning composition followed by use of a secondary complementary composition.
  • the inventors have overcome the foregoing challenges and provide a water-based skin conditioning composition that supports and, in some particular embodiments, boosts the activity of skin actives.
  • the skin conditioning composition is stable from pH increase and crystallization to maintain a high amount of urea for achieving efficacy as a humectant, for promoting the stratum corneum to swell, and for stimulating skin desquamation, among other possible benefits.
  • the disclosure provides a cosmetic skin care composition comprising a skin conditioning composition with high urea content in different formats selected from a water toner, a gel, a mask, a micellar water, a cream, a lotion, a cleanser, or a make-up remover.
  • an inventive skin conditioning composition may be used alone or as a first step prior to application of a secondary complementary composition comprising one or more actives, such as a hydroxy acid or other water soluble actives.
  • the inventive composition my boost the efficacy of the active or actives, for example for skin rejuvenation or conditioning.
  • a skin conditioning composition that includes a carrier system having a water phase, the water phase including urea or a derivative thereof, present in an amount from about 20% to about 40%, by weight, based on the weight of the composition; at least one amino acid; at least one of triacetin or triethyl citrate; and, optionally, a buffer system having a pH in a range from about 4.0 to about 6.0, wherein the pH of the skin conditioning composition is less than about 7.
  • the skin conditioning composition carrier system may also include one more additional ingredients, each present in the water phase or in a second phase.
  • the invention provides a skin conditioning composition, comprising: urea or a derivative thereof, present in an amount from about 20% to about 40%, by weight, based on the weight of the composition; at least one amino acid; at least one of triacetin or triethyl citrate; optionally, a buffer system having a pH in a range from about 4.0 to about 6.0, wherein the pH of the skin conditioning composition is less than about 7.
  • the composition is formulated as a leave-on product.
  • the at least one amnio acid is soluble in water at a pH from about 4 to about 6.
  • the at least one amnio acid is selected from the group consisting of glycine, proline, serine, cysteine and combinations thereof.
  • the at least one amnio acid is present in an amount from about 5% to about 9%, by weight, based on the weight of the composition.
  • the at least one of triacetin or triethyl citrate is present in an amount from about 0.2% to about 2%%, by weight, based on the weight of the composition.
  • the invention provides a skin conditioning composition wherein the at least one amino acid is selected from the group consisting of glycine, proline, serine, cysteine and combinations thereof and is present in an amount from about 5% to about 9%, by weight, based on the weight of the composition; and the at least one of triacetin or triethyl citrate, is present in an amount a range that includes about 0.2% to about 2%, by weight, based on the weight of the composition; and wherein the skin conditioning composition comprises a buffer system comprising one or a combination of components selected from the group consisting of citric acid, sodium citrate, sodium lactate, lactic acid, and combinations thereof, wherein the skin conditioning composition demonstrates structural and pH stability for periods of up to about 8 weeks under temperature conditions that range from 4 o C up to 45 o C and through freeze thaw cycles from -20 o C through 20 o C, characterized as the absence of any or sustained visible crystallization and the stabilization of pH at or under a pH
  • the skin conditioning composition further comprising at least one pH adjusting reagent comprising triethanolamine.
  • the urea or a derivative thereof is present in an amount from greater than about 20% to about 40%, by weight, based on the weight of the composition, and further comprising at least one glycol selected from the group consisting of propylene glycol, glycerin, and combinations thereof.
  • the skin conditioning composition comprises propylene glycol and excludes glycerin.
  • the invention provides a skin conditioning composition, comprising: urea present from greater than 20% to about 40%; at least one amino acid, the at least one amino acid comprising glycine present from about 5% to about 9%; at least one of triacetin or triethyl citrate, present from about 0.2% to about 2%; a buffer system having a pH in a range from about 4.0 to about 6.0; at least one pH adjusting reagent, comprising triethanolamine; and at least one glycol selected from the group consisting of propylene glycol, glycerin, and combinations thereof, wherein all amounts are by weight, based on the weight of the composition, and wherein the pH is from about 4.0 to about 6.0, and wherein the skin conditioning composition demonstrates structural and pH stability for periods of up to about 8 weeks under temperature conditions that range from 4 o C up to 45 o C and through freeze thaw cycles from -20 o C through 20 o C, characterized as the absence of any or sustained visible crystall
  • the skin conditioning composition comprises propylene glycol and excludes glycerin.
  • the buffer system comprises one or a combination of components selected from the group consisting of citric acid, sodium citrate, sodium lactate, lactic acid, and combinations thereof.
  • the buffer system comprises sodium lactate and lactic acid.
  • the invention provides a skin conditioning composition, comprising: a carrier system comprising a water phase, the water phase comprising urea or a derivative thereof, present in an amount from about 20% to about 40%, by weight, based on the weight of the composition; at least one amino acid; at least one of triacetin or triethyl citrate; and, optionally, a buffer system having a pH in a range from about 4.0 to about 6.0, wherein the pH of The skin conditioning composition is less than about 7.
  • the carrier system further comprises one more additional ingredients, each present in the water phase or in a second phase.
  • the one or more additional ingredients includes one or more of an additional ingredient selected from the group consisting of a skin active compound, a humectant in addition to any glycol, an oil, a surfactant, a thickener, a preservative, and combinations thereof.
  • the skin conditioning composition is one of a single phase solution comprising the water phase, a multi-phase solution comprising at least one additional phase, or an emulsion comprising at least one oily phase.
  • the skin conditioning composition is a product for keratinous tissue selected from a water toner, a gel, a mask, a micellar water, a cream, a lotion, a cleanser, or a make-up remover.
  • the skin conditioning composition is a leave-on formulation.
  • the present disclosure provides a method of contacting a portion of skin with skin conditioning composition with or without an implement or an applicator. The methods may further include application of a complementary composition, before or after application of the skin conditioning composition.
  • a home use skin conditioning composition with high urea content in different formats selected from a water toner, a gel, a mask, a micellar water, a cream, a lotion, a cleanser, or a make-up remover.
  • the skin conditioning composition is used as first step prior to application of a complementary composition comprising one or more actives, such as a hydroxy acid or other water soluble actives, to boost the efficacy of the active or actives, for example for skin rejuvenation.
  • a method of use includes application of the skin conditioning composition as a leave on for providing moisture retention benefits.
  • a method of use includes application of the skin conditioning composition as a leave on, followed by application, of a complementary composition, such as, but not limited to, a complementary composition containing one or more actives that can complement or supplement the benefits of the skin conditioning composition.
  • a complementary composition such as, but not limited to, a complementary composition containing one or more actives that can complement or supplement the benefits of the skin conditioning composition.
  • the disclosure provides a system (or kit) employing the skin conditioning composition and one or more complementary compositions comprising one or more actives, such as a hydroxy acid or other water soluble actives.
  • the disclosure provides a regimen employing the skin conditioning composition.
  • the regimen includes application, in one, two, three or more application steps of a first composition comprising at least one of the skin conditioning composition and a complementary composition, and a second composition comprising at least one of the skin conditioning composition and a complementary composition.
  • the first and second compositions are different.
  • the first and second compositions are the same.
  • the first composition comprises the skin conditioning composition
  • the second composition comprises the complementary composition.
  • the first composition comprises the complementary composition
  • the second composition comprises the skin conditioning composition.
  • Application may include three or more sequential steps where first and second compositions are applied in any order.
  • both compositions are either left on the skin or may be removed by rinsing.
  • the application of one or both may include use of an implement such as a brush.
  • the present disclosure provides a method of contacting a portion of skin with skin conditioning composition with or without an implement or an applicator. The methods may further include application of a complementary composition, before or after application of the skin conditioning composition.
  • a method improving the efficacy of a skin care active comprising: a) applying to a region of skin a first composition comprising a skin conditioning composition comprising: a carrier system comprising a water phase, the water phase comprising urea or a derivative thereof, present in an amount from about 20% to about 40%, by weight, based on the weight of the composition; at least one amino acid; at least one of triacetin or triethyl citrate; and, optionally, a buffer system having a pH in a range from about 4.0 to about 6.0, wherein the pH is less than about 7; b) applying to the region of skin a second composition comprising complementary composition comprising one or more skin actives not present in the skin conditioning composition.
  • a skin conditioning composition comprising: a carrier system comprising a water phase, the water phase comprising urea or a derivative thereof, present in an amount from about 20% to about 40%, by weight, based on the weight of the composition; at least one amino acid; at least one of triacetin or
  • the steps of the method include (a) and (b) in any order.
  • each of the compositions is aqueous and is applied in liquid form.
  • the first composition is one of a water- based toner or a mask.
  • the first composition is a water-based toner that is applied first followed by the second composition without prior removal of the first composition.
  • the first composition is a water-based mask that is applied first followed by the second composition, the method further comprising a step that includes rinsing to remove the first composition prior to application of the second composition.
  • one or both of the first and second compositions is coupled to an application surface of an applicator, the application surface selected from the group consisting of a bristle surface of a brush, a roller surface of a rolling applicator, and a blade surface of a spatula
  • an article of manufacture for providing a skin system for improving the efficacy of a skin care active comprising: at least first and second separately contained compositions.
  • the first composition comprising a skin conditioning composition
  • a skin conditioning composition comprising: a carrier system comprising a water phase, the water phase comprising urea or a derivative thereof, present in an amount from about 20% to about 40%, by weight, based on the weight of the composition; at least one amino acid; at least one of triacetin or triethyl citrate; and, optionally, a buffer system having a pH in a range from about 4.0 to about 6.0, wherein the pH is less than about 7, and the second composition comprising a complementary composition comprising one or more skin actives not present in the skin conditioning composition.
  • the first and second compositions are one of (i) contained to be mixable prior to application to skin, and (ii) contained to be applied separately, in any order.
  • one or both compositions may be coupled to an application surface of an applicator.
  • the application surface may be a surface of a mask configured to conform to a face of a wearer.
  • the application surface may be selected from the group consisting of a bristle surface of a brush, a roller surface of a rolling applicator, and a blade surface of a spatula.
  • the skincare formulation may be disposed in a first compartment of a sachet and the application surface may be a surface of a second compartment of the sachet, and wherein the first compartment and the second compartment are fluidically separated by a breakable barrier.
  • FIG. 1 is a bar graph that shows stratum corneum test results demonstrating the comparative efficacy of the inventive composition used according to the inventive methods as compared with controls.
  • FIG. 2 is a bar graph that shows stratum corneum test results demonstrating the comparative efficacy of the inventive composition at different concentrations of urea and used according to the inventive methods as compared with controls.
  • FIG. 3 is a bar graph that shows stratum corneum test results demonstrating the comparative efficacy of the inventive composition employing different forms of urea and used according to the inventive methods as compared with controls.
  • the skin conditioning composition of the present invention may be used for the production of cosmetic preparations, or dermatological preparations, more particularly topical treatment preparations, that may be formulated as single-phase water-based solution compositions, cosmetic serums, or aerosols, for example.
  • Topical application to a surface may be a surface such as the mucus membrane or the skin, for example.
  • the disclosure provides a cosmetic skin care composition comprising a skin conditioning composition with high urea content in different formats selected from a water toner, a gel, a mask, a micellar water, a cream, a lotion, a cleanser, or a make-up remover.
  • an inventive skin conditioning composition may be used alone or as a first step prior to application of a secondary complementary composition comprising one or more actives, such as a hydroxy acid or other water soluble actives.
  • the inventive composition my boost the efficacy of the active or actives, for example for skin rejuvenation or conditioning.
  • skin conditioning and “skin rejuvenation” in reference to the inventive skin conditioning composition means acting as a humectant as a means to promote the stratum corneum to swell, and for stimulating skin desquamation.
  • the skin conditioning composition is especially useful according to methods for rejuvenation including application of the skin conditioning composition to promote the stratum corneum of skin to swell to thereby stimulate the skin to be responsive to a secondary treatment.
  • Cosmetically acceptable means compatible with any keratinous substrate.
  • cosmetically acceptable carrier means a carrier that is compatible with any keratinous substrate.
  • stable as used in reference to the structural or solubility state of the ingredients of the skin conditioning composition means that the skin conditioning composition lacks crystal formation that is visible to the naked eye, and does not demonstrate visually perceptible crystal formation over a period of time, for example for one, two or four or five days, or for a period of one or more weeks, and for example up to eight (8) weeks, and wherein when crystals are visualized at a temperature at or below 4 °C, such crystals disappear with or without mild agitation within 24 hours of reaching an ambient temperature from about 25 °C up to about 37 °C and after freeze thaw cycles from -20 o C through 20 o C.
  • the term “stable” as used in reference to the pH the skin conditioning composition means that the pH does not increase appreciably over time, for example as described in the examples herein.
  • the term “leave-on” as used herein refers to a composition which is applied and is not removed by wiping or rinsing with water.
  • the disclosure provides a home use skin conditioning composition with high urea content in different formats selected from a water toner, a gel, a mask, a micellar water, a cream, a lotion, a cleanser, or a make-up remover.
  • the skin conditioning composition is used as first step prior to application of a complementary composition comprising one or more actives, such as a hydroxy acid or other water soluble actives, to boost the efficacy of the active or actives, for example for skin rejuvenation.
  • a skin rejuvenation or skin conditioning composition demonstrates structural and pH stability for periods of up to about 8 weeks under temperature conditions that range from 4 o C up to 45 o C and through freeze thaw cycles from -20 o C through 20 o C.
  • the stabilities are characterized as the absence of any or sustained visible crystallization and the stabilization of pH at or under a pH of about 7, and in some particular embodiments that include greater than 20% and up to at least 40% urea.
  • the composition can surprisingly improve the efficacy of a second complimentary composition that includes at least one skin active.
  • the skin conditioning composition stabilities are characterized as the absence of any or sustained visible crystallization and the stabilization of pH at or under a pH of about 7, in particular in embodiments that include greater than 20% and up to at least 40% urea. Examples provided herein demonstrate these and other aspects of the unexpected properties of the skin conditioning composition.
  • the invention also provides methods of use of the skin conditioning composition for rejuvenation of the skin.
  • a method of use includes application of the skin conditioning composition as a leave on for providing moisture retention benefits.
  • a method of use includes application of the skin conditioning composition as a leave on, followed by application, of a complementary composition, such as, but not limited to, a complementary composition containing one or more actives that can complement or supplement the benefits of the skin conditioning composition.
  • a complementary composition such as, but not limited to, a complementary composition containing one or more actives that can complement or supplement the benefits of the skin conditioning composition.
  • the disclosure provides a system (or kit) employing the skin conditioning composition and one or more complementary compositions comprising one or more actives, such as a hydroxy acid or other water soluble actives.
  • the disclosure provides a regimen employing the skin conditioning composition.
  • the regimen includes application, in one, two, three or more application steps of a first composition comprising at least one of the skin conditioning composition and a complementary composition, and a second composition comprising at least one of the skin conditioning composition and a complementary composition.
  • the first and second compositions are different.
  • the first and second compositions are the same.
  • the first composition comprises the skin conditioning composition
  • the second composition comprises the complementary composition.
  • the first composition comprises the complementary composition
  • the second composition comprises the skin conditioning composition.
  • Application may include three or more sequential steps where first and second compositions are applied in any order.
  • both compositions are either left on the skin or may be removed by rinsing.
  • the application of one or both may include use of an implement such as a brush.
  • Skin conditioning composition is formed by providing the carrier system having a water-phase that comprises water.
  • the carrier system may further comprise one more additional ingredients, each present in the water phase or in another phase, such as an oily phase.
  • the one or more additional ingredients includes one or more of an additional ingredient selected from the group consisting of a skin active compound, humectant in addition to any glycol, a preservative, a surfactant, a thickener, and combinations thereof.
  • the skin conditioning composition may include one or more of any one of the additional ingredients.
  • the skin conditioning composition may also include fragrances, pH adjusters, other cosmetically acceptable additives, or a combination thereof.
  • the skin conditioning composition may be any suitable form, such as, but not limited to, a single phase solution comprising the water phase, a multi-phase solution comprising at least one water phase, an emulsion comprising a water phase and an oily phase, such as, but not limited to, a water-in-oil emulsion, an oil-in-water emulsion, or a silicone-in-water emulsion.
  • the skin conditioning composition may be provided in a product form for application to keratinous tissue, such as, but not limited to, a skin care product or a hair care product, and may be a product form such as, but not limited to, a micellar water, a cream or lotion, a toner, a cleanser, or a make-up remover.
  • the skin conditioning composition in any of the product forms may be either a leave-on or a rinse-off formulation. In certain embodiments, as exemplified herein, the skin conditioning composition is a leave-on formulation.
  • the skin conditioning composition includes a carrier system having a water phase, the water phase including urea or a derivative thereof, present in an amount from about 20% to about 40%, by weight, based on the weight of the composition; at least one amino acid; at least one of triacetin or triethyl citrate; and, optionally, a buffer system having a pH in a range from about 4.0 to about 6.0, wherein the pH of the skin conditioning composition is less than about 7.
  • the skin conditioning composition carrier system may also include one more additional ingredients, each present in the water phase or in a second phase.
  • the skin conditioning composition includes urea present in an amount sufficient to enhance penetration of the active ingredient(s).
  • urea may be provided as one of urea, or a urea derivative, for example, hydroxyethyl urea (HEU), wherein urea has a formula (I) and HEU has a formula (II) as shown below.
  • HEU hydroxyethyl urea
  • a urea or a derivative thereof is selected for its beneficial effects to the skin, which effect is to be enhanced by exposure to urea of the viable epidermis and/or dermis, which underlies the stratum corneum, wherein a urea derivative can be described by the general formula (III): R 1 R 2 N—C( ⁇ O)—NR 3 R 4 (III) wherein R1, R2, R3 and R4 each represent, independently of each other, a hydrogen atom, a C1-C4 alkyl group or a C2-C6 hydroxyalkyl group which optionally contains from 1 to 5 hydroxyl groups, where at least one of the radicals R1 to R4 represents a hydroxyalkyl group, and their salts, their solvates and their isomers in a composition containing a physiologically acceptable medium, as agent intended for stimulating desquamation of the skin and/or the mucous membranes and/or the superficial body growths.
  • R denotes a C2-C6 hydroxyl group
  • R2, R3 and R4 denote, independently of each other, a hydrogen atom or a C1-C4 alkyl group.
  • R1 denotes a C2-C6 hydroxyalkyl group comprising from 1 to 5 hydroxyl groups, in particular 1 hydroxyl group
  • R2, R3 and R4 denote a hydrogen atom.
  • R1 denotes a C2-C4 hydroxyalkyl group comprising 1 hydroxyl group
  • R2, R3 and R4 denote a hydrogen atom.
  • alkyl groups there may be mentioned in particular methyl, ethyl, n- propyl, isopropyl, n-butyl, isobutyl and tert-butyl groups.
  • hydroxyalkyl groups those containing a single hydroxyl group are preferred, and in particular the hydroxyethyl, hydroxypropyl, hydroxybutyl, hydroxypentyl and hydroxyhexyl groups, are preferred.
  • salts there may be mentioned in particular the salts of inorganic acids, such as sulphuric acid, hydrochloric acid, hydrobromic acid, hydriodic acid, phosphoric acid and boric acid.
  • organic acids which may contain one or more carboxylic, sulphonic or phosphonic acid groups. They may be linear, branched or cyclic aliphatic acids or aromatic acids. These acids may additionally contain one or more heteroatoms chosen from O and N, for example in the form of hydroxyl groups. There may be mentioned in particular propionic acid, acetic acid, terephthalic acid, citric acid and tartaric acid.
  • the expression solvate is understood to mean a stoichiometric mixture of the said compound of formula (III) with one or more molecules of water or of organic solvent, such a mixture typically being obtained from the synthesis of the compound of formula (III).
  • N-(2-hydroxyethyl)urea N- (2-hydroxypropyl)-urea; N-(3-hydroxypropyl)urea; N-(2,3-dihydroxypropyl)-urea; N-(2,3,4,5,6- pentahydroxyhexyl)urea; N-methyl-N-(1,3,4,5,6-pentahydroxy-2-hexyl)urea; N-methyl-N′-(1- hydroxy-2-methyl-2-propyl)urea; N-(1-hydroxy-2-methyl-2-propyl)urea; N-(1,3-dihydroxy-2- propyl)urea; N-(tris-hydroxymethylmethyl)urea; N-ethyl-N′-(2-hydroxyethyl)urea; N,N-bis(2- hydroxyethyl)urea; N,N′-bis(2-hydroxyethyl)urea; N,N-bis(2-hydroxyethyl)urea; N,N′-bis(
  • total amount of the urea or derivative thereof is in a range from about 20% to about 40%, or from about 20% to about 35%, or from about 25% to about 30%, or from about 25% to about 40%, or from about 30% to about 35% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • total amount of the urea or derivative thereof is in a range from about 20% to about 40%, or from about 20% to about 35%, or from about 25% to about 30%, or from about 25% to about 40%, or from about 30% to about 35% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • the urea or derivative thereof is present, by weight, based on the total weight of the composition, from about 20, 21, 22, 23, 24, 25,26,27,28, 29, 30, 31,32, 33, 34, 35,36,37, 38, 39 to about 40 weight percent, including increments and ranges therein and there between.
  • Amino Acid [0089]
  • the skin conditioning composition includes at least one or more amino acids.
  • the at least one amino acid may be selected from the group consisting of naturally occurring amino acids.
  • the at least one amino acid may be selected from glycine, proline, serine and cysteine.
  • the at least one amino acid comprises glycine.
  • the amino acids that may be used may be of natural or synthetic origin, in L, D, or racemic form, and comprise at least one acid function chosen from, for instance, carboxylic acid, sulfonic acid, phosphonic acid, and phosphoric acid functions.
  • the amino acids may be in their neutral or ionic form.
  • Polymeric forms are also useful, such as poly arginine, poly lysine, etc.
  • Additional non-limiting examples include basic amino acids comprising an additional amine function optionally included in a ring or in a ureido function.
  • amino acids that may be used include, but are not limited to, aspartic acid, glutamic acid, alanine, arginine, ornithine, citrulline, asparagine, carnitine, cysteine, glutamine, glycine, histidine, lysine, isoleucine, leucine, methionine, N-phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, ornithine, citrulline, and valine.
  • the amount of amnio acid present in a composition according to the disclosure can range from about 2% to about 10%, or from about 3% to about 9%, or from about 4% to about 8%, or from about 3% to about 5%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • the composition includes at least about 3%, or at least about 5% of the at least one amino acid.
  • the composition includes not more than about 9% of the at least one amino acid.
  • the skin conditioning composition includes at least one or more of triacetin or triethyl citrate.
  • the amount of triacetin or triethyl citrate present in a composition according to the disclosure can range from about 0.2% to about 2%, or from about 0.3% to about 1.5%, or from about 0.5% to about 1.2%, or from about 0.7% to about 1%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • the skin conditioning composition includes at least about 0.2%, or at least about 0.7% of the triacetin or triethyl citrate.
  • the skin conditioning composition includes not more than about 1% of the triacetin or triethyl citrate.
  • any one of or a combination of the triacetin or triethyl citrate may be present, by weight, based on the total weight of the skin conditioning composition, or from about 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, to about 2 weight percent, including increments and ranges therein and there between.
  • the skin conditioning composition may include a buffer system.
  • the buffer system comprises one or a combination of components selected from the group consisting of citric acid, sodium citrate, sodium lactate, lactic acid, and combinations thereof. In some particular embodiments, the buffer system comprises sodium lactate, lactic acid, ammonium lactate, and combinations thereof. In some particular embodiments, the buffer system comprises citric acid, sodium citrate, and combinations thereof. [0099] More generally, the buffer system is selected from conventional buffer systems commonly used for compositions used on keratinous tissue, particularly skin. Buffer systems may include one or a combination of acidifying agents and alkalifying agents.
  • Acidifying agents include, for example, organic or inorganic acids such as hydrochloric acid, orthophosphoric acid, sulphuric acid, carboxylic acids such as acetic acid, tartaric acid, citric acid and lactic acid, and sulphonic acids.
  • Alkalifying agents include, for example, aqueous ammonia, alkali metal carbonates, alkanolamines such as mono-, di- and triethanolamines and their derivatives, sodium hydroxide or potassium hydroxide.
  • a buffer system comprising, for example, sodium lactate, lactic acid, ammonium lactate, and combinations thereof, includes each of the buffer system components present in a range from about 0.1% to about 3%, or from about 0.25% to about 2.5%, or from a total of about 0.1% to about 6%, or from about 0.25% to about 5.25%, or any suitable combination, sub-combination, range, or sub- range thereof by weight, based on the weight of the skin conditioning composition. More generally, in some embodiments according to the disclosure, the skin conditioning composition includes each one or more buffer components present in a range from about 0.1% to about 15%.
  • any one of or a combination of buffer system components may be present, by weight, based on the total weight of the skin conditioning composition, or from about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 13, 14, to about 15 weight percent, including increments and ranges therein and there between.
  • the skin conditioning composition may include at least one alkanol, and particularly at least one glycol.
  • the skin conditioning comprises one or a combination of alkanols (polyhydric alcohols such as glycols and polyols).
  • the skin conditioning comprises one or a combination of propylene glycol, glycerin, propanediol, butylene glycol, dipropylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, and combinations thereof.
  • the skin conditioning may comprise at least propylene glycol, with or without glycerin.
  • the skin conditioning may comprise one or a combination of the 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, diethylene glycol, butylene glycol, hexylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, 1,5- pentanediol, tetraethylene glycol, 1,6-hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, 2-butene-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl- 2,4-pentanediol, (capryly
  • the amount of the at least one glycol present in the skin conditioning composition can range from about 1% to about 15%, or from about 2% to about 12%, or from about 3% to about 10%, or from about 3.5% to about 5%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • the amount of the at least one glycol present in the skin conditioning composition can range from about 1% to about 15%, or from about 2% to about 12%, or from about 3% to about 10%, or from about 3.5% to about 5%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • any one of or a combination of glycol, when present, may be present, by weight, based on the total weight of the skin conditioning composition, is from about 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10, 10.5, 11, 11.5, 12, 12.513, 13.5, 14, 14.5, to about 15 percent, by weight, based on the weight of the skin conditioning composition, including increments and ranges therein and there between.
  • the skin conditioning composition is formed by providing a carrier system having a water-phase that comprises water.
  • the urea, amino acid, triacetin/Triethyl citrate, and buffer system components are typically preferentially in the water phase.
  • the skin conditioning composition may include other ingredients, and the carrier system may include other phases, including one or more additional water and/or oil phases.
  • Water Phase/Water In various embodiments, the skin condition composition includes at least one water phase that includes water. [00111]
  • the skin conditioning composition comprises from about 40% to about 70% by weight of water, with respect to the total weight of the skin conditioning composition.
  • the amount of water in the skin conditioning composition can range from about 40% to about 70%, or from about 45% to about 65%, or from about 50% to about 60%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • the pH of the skin conditioning composition is in the range from and including about 4 to about 6, and in some embodiments is one of between 5.5 and 6.5, or between 4 and 5, or between 5 and 6, or up to about 7.
  • the pH can be adjusted to the desired value by addition of a base (organic or inorganic) to the skin conditioning composition, for example ammonia or a primary, secondary or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1,3-propanediamine, or alternatively by addition of an inorganic or organic acid, for example a carboxylic acid, such as, for example, citric acid.
  • a base organic or inorganic
  • a primary, secondary or tertiary (poly)amine such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1,3-propanediamine
  • an inorganic or organic acid for example a carboxylic acid, such as, for example, citric acid.
  • water may be present by weight, based on the total weight of the skin conditioning composition, or from about 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, to about 70 weight percent, including increments and ranges therein and there between.
  • Optional Components [00115] Cosmetic Oils/Emollients
  • the skin conditioning composition may comprise at least one oily phase which may include any one or a combination of cosmetic oils.
  • the oil is generally immiscible in water.
  • the oil may be selected from hydrocarbons, silicones, fatty alcohols, glycols, and vegetable oils.
  • the oil may include one or a combination of polar and non-polar oil.
  • the oil may be chosen from hydrocarbon-based oils from plants or of plant origin, mineral oil, ester oils, fatty alcohols containing from 12 to 26 carbon atoms, fatty acids containing from 12 to 26 carbon atoms and vinylpyrrolidone copolymers, and combinations thereof.
  • the oil may be selected from the group consisting of, coco-caprylate/caprate, dicaprylyl carbonate, dicaprylyl ether, isopropyl palmitate, and combinations thereof.
  • Silicone oil relates to oil comprising at least one silicon atom, and especially at least one Si-O group.
  • fluoro oil relates to oil comprising at least one fluorine atom.
  • hydrocarbon-based oil relates to oil comprising mainly hydrogen and carbon atoms. Hydrocarbon-based oil may be animal hydrocarbon-based oil, plant hydrocarbon-based oil, mineral hydrocarbon-based oil, or a synthetic hydrocarbon-based oil. Further, suitable oil may be a mineral hydrocarbon-based oil, a plant hydrocarbon-based oil, or a synthetic hydrocarbon-based oil.
  • the skin conditioning composition may comprise one or more silicone oils.
  • Non- limiting examples of silicone oils include dimethicone, cyclomethicone, polysilicone-11, phenyl trimethicone, trimethylsilylamodimethicone, and stearoxytrimethylsilane.
  • the skin conditioning composition includes dimethicone, and optionally additional oils, including additional silicone oils.
  • the one or more silicone oils is a non-volatile silicon oil.
  • the silicone oil is polydimethylsiloxanes (PDMSs), polydimethylsiloxanes comprising alkyl or alkoxy groups which are pendent and/or at the end of the silicone chain, which groups each contain from 2 to 24 carbon atoms, or phenyl silicones, such as phenyl trimethicones, phenyl dimethicones, phenyl(trimethylsiloxy)diphenylsiloxanes, diphenyl dimethicones, diphenyl(methyldiphenyl)trisiloxanes or (2-phenylethyl)trimethylsiloxysilicates.
  • PDMSs polydimethylsiloxanes
  • phenyl silicones such as phenyl trimethicones, phenyl dimethicones, phenyl(trimethylsiloxy)diphenylsiloxanes, diphenyl dimethicones, diphenyl(methyldiphenyl)trisi
  • silicone oils that may be mentioned include volatile linear or cyclic silicone oils, especially those with a viscosity 8 centistokes (8x106 m2/s) and especially containing from 2 to 7 silicon atoms, these silicones optionally comprising alkyl or alkoxy groups containing from 1 to 10 carbon atoms.
  • the skin conditioning composition may comprise one or more fluoro oils.
  • the one or more fluoro oil may be selected from the group consisting of perfluoromethylcyclopentane, perfluoro-1,3-dimethylcyclohexane, dodecafluoropentane, tetradecafluorohexane, bromoperfluorooctyl, nonafluoromethoxybutane, nonafluoroethoxyisobutane and 4-trifluoromethylperfluoromorpholine.
  • Volatile fluoro oils such as nonafluoromethoxybutane, decafluoropentane, tetradecafluorohexane, dodecafluoropentane, may also be used.
  • the skin conditioning composition may comprise one or more hydrocarbon-based oils.
  • the hydrocarbon-based oil may be a saturated hydrocarbon, an unsaturated hydrocarbon, lipids, triglycerides, a natural oil, and/or a synthetic oil.
  • the skin conditioning composition may include a synthetic oil selected from the group consisting of hydrogenated polyisobutene and hydrogenated polydecene.
  • a hydrocarbon- based oil may be a non-volatile hydrocarbon-based, such as: (i) hydrocarbon-based oils of plant origin, such as glyceride triesters, which are generally triesters of fatty acids and of glycerol, the fatty acids of which can have varied chain lengths from C4 to C24, it being possible for these chains to be saturated or unsaturated and linear or branched; these oils are in particular wheat germ oil, sunflower oil, grape seed oil, sesame oil, corn oil, apricot oil, castor oil, shea oil, avocado oil, olive oil, soybean oil, sweet almond oil, palm oil, rapeseed oil, cottonseed oil, hazelnut oil, macadamia oil, jojoba oil, alfalfa oil, poppy oil, pumpkin seed oil, marrow oil, blackcurrant oil, evening primrose oil, millet oil, barley oil, quinoa oil, rye oil, safflower oil, candlenut oil, passionflower oil, and
  • Hydrocarbon-based oils may be glyceride triesters and in particular to caprylic/capric acid triglycerides, synthetic esters and in particular isononyl isononanoate, oleyl erucate, C12- C15 alkyl benzoate, 2-ethylphenyl benzoate and fatty alcohols, such as octyldodecanol.
  • hydrocarbon-based oils containing from 8 to 16 carbon atoms and in particular of branched C8-C16 alkanes, such as C8-C16 isoalkanes of petroleum origin (also known as isoparaffins), such as isododecane (also known as 2,2,4,4,6- pentamethylheptane), isodecane or isohexadecane, the oils sold under the Isopar or Permethyl trade names, branched C C8-C16 esters, and isohexyl neopentanoate.
  • C8-C16 alkanes such as C8-C16 isoalkanes of petroleum origin (also known as isoparaffins), such as isododecane (also known as 2,2,4,4,6- pentamethylheptane), isodecane or isohexadecane, the oils sold under the Isopar or Permethyl trade names, branched C C8-C16 esters, and iso
  • the skin conditioning composition may comprise one or more oils such as from those described herein above, and from oils that may be selected from branched or linear, liquid alkane with carbon chain length of C11 to C20.
  • liquid alkanes may be selected from those with a carbon chain length of from C11 to C20.
  • the liquid alkanes may be selected from those with a carbon chain length of from C11 to C20, or from C15 to C19, or one of C11, C12, C13, C14, C15, C16, C17, C18 to C19.
  • suitable liquid alkanes that may be used according to the disclosure include hydrocarbon-based oils containing from 8 to 16 carbon atoms, and especially branched C8-C16 alkanes such as C8-C16 isoalkanes.
  • the skin conditioning composition may comprise one or more oils selected from polar emollients selected from esters, triglycerides, ethers, carbonates, alcohols, oils, butters, fatty acids, and their combinations thereof.
  • the polar emollients may be selected from those with a molecular weight of 400 g/mol or less.
  • the polar emollient may have a molecular weight in the range from about 50 g/mol% to about 350 g/mol.
  • the skin conditioning composition may comprise polar emollients that include those derived from C12-C50 fatty acids, preferably C16-C22 saturated fatty acids, and monohydric alcohols.
  • esters may be chosen from isopropyl myristate, methyl palmitate, isopropyl laurate, isopropyl palmitate, ethylhexyl palmitate, ethylhexyl laurate, ethylhexyl oleate, ethylhexyl isononanoate, myristyl myristate, 2- ethylhexyl caprate/caprylate (or octyl caprate/caprylate), 2-ethylhexyl palmitate, isostearyl neopentanoate, isononyl isononanoate, hexyl laurate, esters of lactic acid and of fatty alcohols comprising 12 or 13 carbon atoms, dicaprylyl carbonate and their mixtures.
  • the one or more oil when present, alone or in combination as a blend of oils, may be present in the skin conditioning composition from about 0.0001% to about 20% or from about 0.001% to about 0.0010%, or from about 0.003% to about 0.004%, or from about 0.01% to about 0.1%, or from about 0.1% to about 10%, or from about 0.5% to about 20%, or from about 1% to about 10%, or from about 5% to about 10%, or from about 2% to about 7%, or from about 0.5% to about 2%, or from about 0.008% to about 0.01%, or from about 0.1% to about 0.2%, or from about 0.5% to about 2%, or from about or any suitable combination, sub- combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • the skin conditioning composition includes more than one oil, each oil present in an amount as set forth herein above, wherein each different oil (such as, for example, plant oils and extracts with oils) may be present within one of the ranges selected from the ranges set forth herein above.
  • each of the at least one oil or combination of oils, if present, is present by weight, based on the total weight of the skin conditioning composition, from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 to about 20 percent, including increments and ranges therein and there between.
  • various non-limiting embodiments of the skin conditioning composition may optionally include at least one surfactant.
  • various non-limiting embodiments of the skin conditioning composition that include an oil, for example, but not limited to, a Vitamin E component, such as tocopherol may optionally include at least one surfactant.
  • the skin conditioning composition comprises no oil.
  • the skin conditioning composition comprises no surfactant.
  • the skin conditioning composition comprises at least one oil, for example, tocopherol, with at least one surfactant.
  • the skin conditioning composition comprises at least one oil with more than one surfactant.
  • the skin conditioning composition comprises at least one oil without any surfactants, wherein the total amount of oil present does not inhibit forming the skin conditioning composition as a clear, single phase solution.
  • the at least one surfactant may be an nonionic, cationic, anionic, or a zwitterionic surfactant.
  • the at least one surfactant may be selected from the group consisting of polyoxyethylene sorbitan monolaureate, laureth-23, polyoxyethylated octyl phenol, 3-((3- cholamidopropyl) dimethylammonio)-1 propane sulfonate, sodium dilauramidoglutamide lysine, cholate, deoxycholate, sodium dodecylsulfate, TWEEN-80, and combinations thereof.
  • the at least one surfactant may exclude esters.
  • the at least one surfactant may be present in the skin conditioning composition in a range from about 1% to about 5%, based on the weight of the skin conditioning composition.
  • the at least one surfactant when present, comprises one or a combination of polyoxyethylene sorbitan monolaureate and laureth-23.
  • the at least one surfactant when present, may be present from about 1% to about 5% by weight of the skin conditioning composition, and in some embodiments, from about 1% to about 2% , and in some embodiments, from about 3% to about 6%, and in some embodiments, from about 3% to about 4.5%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • laureth-23 may be present from about 1% to about 5% by weight of the skin conditioning composition, and in some embodiments, from about 3% to about 4.5%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • polyoxyethylene sorbitan monolaureate may be present from about 1% to about 5% by weight of the skin conditioning composition, and in some embodiments, from about 1% to about 2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • the skin conditioning composition comprises more than one surfactant.
  • each of the at least one surfactant when present, may be present in a composition according to the disclosure from about 1, 2, 3, 4, to about 5 percent, by weight, including increments and ranges therein and there between.
  • Polymeric Thickener In accordance with the disclosure, various non-limiting embodiments of the skin conditioning composition may optionally include one or more polymeric thickeners.
  • the one or more thickener may be selected from one or more of natural gums and synthetic polymers, for example, the thickener may be selected from the group consisting of starches (corn, rice, tapioca, potato), gums (xanthan carrageenan, gellan, sclerotium, tarabiotech fermentation).
  • the thickener may be selected from acrylates/C10-30 alkyl acrylate crosspolymer, carbomer, xanthan gum, hydroxypropyl guar, ceratonia siliqua (carob) gum, ammonium polyacryloyldimethyl taurate, ammonium acryloyldimethyltaurate/steareth-25 methacrylate crosspolymer, and polyacrylate crosspolymer-6.
  • the polymeric thickener may be one of carbomer, acrylates/C10-30 alkyl acrylate crosspolymer, polyacrylate crosspolymer-6, microcrystalline cellulose (and) cellulose gum, xanthan gum, sodium carboxymethyl starch, sclerotium gum (and) xanthan gum, xanthan gum (and) ceratonia siliqua (carob) gum (50/50), dehydroxanthan gum, hydroxypropyl starch phosphate, sclerotium gum (and) xanthan gum (75/25), sclerotium gum, xanthan gum (and) sclerotium gum (and) Lecithin (and) pullulan, or combinations thereof.
  • the skin conditioning composition may comprise two or more polymeric thickeners.
  • the amount of each of the at least one polymeric thickener, when present, may be present in the skin conditioning composition in a range of from about 0.01% to about 2%, or from about 0.01% to about 1.5%, or from about 0.3% to about 1.2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • One of ordinary skill in the art will appreciate that other ranges are within the scope of the invention.
  • the total amount of polymeric thickener in the skin conditioning composition when present, is present from about 0.01% to about 5%, or from about 0.02% to about 2%, or from about 0.03% to about 1.5%, or from about 0.1% to about 0.2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • any suitable combination, sub-combination, range, or sub-range thereof by weight is present from about 0.01% to about 5%, or from about 0.02% to about 2%, or from about 0.03% to about 1.5%, or from about 0.1% to about 0.2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • one or more polymeric thickener when present, is present by weight, based on the total weight of the skin conditioning composition, from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.5, 4.0, 4.5 to about 5.0 percent, including increments and ranges therein and there between.
  • the skin conditioning composition may optionally include one or more preservatives and/or antimicrobials.
  • Any preservative commonly used in cosmetic formulations is an acceptable preservative for the skin conditioning compositions herein, such as phenoxyethanol, salicylic acid, members from the paraben family such as the methyl, ethyl, propyl, butyl or isobutyl parabens, 4-hydroxy benzoic acid, benzoic acid, sorbic acid, dehydroacetic acid, triclosan, benzyl alcohol, chlorophenesin, or for example.
  • the preservative may comprise one or more of preservatives selected from the group consisting of organic acids, parabens, formaldehyde donors, phenol derivatives, quaternary ammoniums, alcohols, isothiazolinones, and combinations thereof.
  • Preservatives having antibacterial activity are optionally present in the skin conditioning compositions of the present invention.
  • organic acid preservatives include, but are not limited to, sodium benzoate, potassium sorbate, benzoic acid and dehydroacetic acid, sorbic acid, and combinations thereof.
  • a preferred organic acid preservative system includes a mixture of sodium benzoate and potassium sorbate.
  • paraben preservatives include, but are not limited to, alkyl para-hydroxybenzoates, wherein the alkyl radical has from 1, 2, 3, 4, 5 or 6 carbon atoms and for example, from 1 to 4 carbon atoms e.g., methyl para- hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl para- hydroxybenzoate (propylparaben), butyl para-hydroxybenzoate (butylparaben) and isobutyl para-hydroxybenzoate (isobutylparaben).
  • alkyl para-hydroxybenzoates wherein the alkyl radical has from 1, 2, 3, 4, 5 or 6 carbon atoms and for example, from 1 to 4 carbon atoms e.g., methyl para- hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl para- hydroxybenzoate (propylpara
  • formaldehyde donor preservatives include, but are not limited to, 1,3-Dimethylol-5,5-dimethylhydantoin (DMDM hydantoin), imidazolidinyl urea, gluteraldehyde, and combinations thereof.
  • quaternary ammonium preservatives include, but are not limited to, benzalkonium chloride, methene ammonium chloride, benzethonium chloride, and combinations thereof.
  • alcohol preservatives include, but are not limited to, ethanol, benzyl alcohol, dichlorobenzyl alcohol, phenoxyethanol, and combinations thereof.
  • isothiazolone preservatives include, but are not limited to, methylchloroisothiazolinone, methylisothiazolinone, and combinations thereof.
  • Other suitable preservatives include, but are not limited to, chloroacetamide, triclosan and iodopropynyl butylcarbamate, pyridine derivatives (e.g., pyrithione and zinc pyrithione), chlorphenesin, phenyl mercuric salts, phenoxyethanol, and other known preservative systems.
  • the preservative includes one or more preservatives, the one or combination present at a concentration, by weight of about 0.001% to about 5%, or alternatively about 0.05% to about 2.5% or alternatively about 0.1% to about 2.0%, based upon weight of the skin conditioning composition.
  • any one of or a combination of preservatives, when present, may be present, by weight, based on the total weight of the skin conditioning composition, is from about 0.001, 0.002, 0.003 ,0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03 ,0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, to about 5 weight percent, including increments and ranges therein and there between.
  • various non-limiting embodiments of the skin conditioning composition may optionally include one or more other additives or actives(optional components), selected from, for example, actives such as acetyl trifluoromethylphenyl valylglycine; a humectant in addition to any glycol, for example caprylyl glycol, squalane, sugars, such as, glucose, xylitol, maltitol, sorbitol, sucrose pentaerythritol, inositol, pyrrolidone carboxylic acid, lactic acid, lithium chloride, acetamide MEA, , dicyanamide, hyaluronic acid, aloe vera, honey, and seaweed extract; preservative and anti-microbial components (such as those listed above), particularly, for example, salicylic acid, and phenoxyethanol; phenolic compounds, such as chalcones, flavones,
  • one or more optional components can be present in the skin conditioning composition according to the disclosure from about 0.05% to about 50% by weight, or from about 1% to about 30%, or from about 1.5% to about 20%, and from about 5% to about 15%, or from about 0.05% to about 2.5% by weight, or from about 0.1% to about 2%, or from about 0.25% to about 5%, and from about 0.5% to about 10%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • one or more other components can be present in the skin conditioning composition according to the disclosure from about 0.05 to about 50% by weight, or from about 0.05% to about 25% by weight, or from about 0.1 to about 10%, or from about 0.25% to about 5%, and from about 0.5 to about 3.5%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the skin conditioning composition.
  • preservatives may include salicylic acid, and phenoxyethanol.
  • one or a combination of optional components may be present, by weight, based on the total weight of the skin conditioning composition, or from about 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 to about 50 weight percent, including increments and ranges therein and there between.
  • complementary compositions may include any one or more of the ingredients described herein above, and in some examples specifically as described in the Optional Components.
  • Desquamating Agents/Hydroxy Acids [00160]
  • the methods of use may include use of a complementary peel composition comprising at least one active ingredient selected from desquamating agents, for example, hydroxy acids.
  • desquamating agents for example, hydroxy acids.
  • Alpha Hydroxy Acid for example, hydroxy acids.
  • the chemical peel component of the skin-enhancing treatment comprises at least one alpha hydroxy acid.
  • Suitable alpha hydroxy acids include glycolic acid, lactic acid, tartaric acid, mandelic acid, citric acid, ester derivatives thereof and combinations thereof.
  • Exemplary ester derivatives include ester compounds of lactic acid, such as methyl lactate, ethyl lactate, butyl lactate and, similarly, ester compounds of glycolic acid, tartaric acid, mandelic acid, citric acid.
  • One particularly suitable alpha hydroxy acid is lactic acid. Lactic acid, or 2-hydroxypropanoic acid, is provided to the chemical peel composition to provide enhanced exfoliation of the skin.
  • lactic acid also boosts production of glycosaminoglycan (GAG) in the skin, improving the barrier function and moisturization of skin.
  • GAG glycosaminoglycan
  • the alpha hydroxy acid in the chemical peel component of the skin-enhancing treatment excludes at least one of lactic acid, glycolic acid, tartaric acid, mandelic acid, and citric acid.
  • the chemical peel component of the skin-enhancing treatment includes a concentration of alpha hydroxy acid in a range from about 4% to about 15%, or from about 8% to about 14% or from about 9% to about 13%, or from about 10% to about 12%, or is about 10%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peel component of the skin-enhancing treatment.
  • concentration of alpha hydroxy acid in a range from about 4% to about 15%, or from about 8% to about 14% or from about 9% to about 13%, or from about 10% to about 12%, or is about 10%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peel component of the skin-enhancing treatment.
  • the amount of alpha hydroxy acid present is not more than about 10%.
  • any one of or a combination of alpha hydroxy acid is present, by weight, based on the total weight of the chemical peel component of the skin-enhancing treatment, from about 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, to about 15 weight percent, including increments and ranges therein and there between.
  • Beta Hydroxy Acid [00168]
  • the chemical peel component of the skin-enhancing treatment comprises at least one beta hydroxy acid.
  • the chemical peel component of the skin-enhancing treatment includes a beta hydroxy acid comprising salicylic acid.
  • beta-hydroxy acid is understood to mean, according to the present invention, a carboxylic acid having a hydroxyl functional group and a carboxylic functional group separated by two carbon atoms.
  • a beta hydroxy acid can be present in the chemical peel component of the skin-enhancing treatment in the form of the free acid and/or in the form of one of its associated salts (salts with an organic base or an alkali metal, in particular), especially according to the final pH imposed on the chemical peel component of the skin-enhancing treatment.
  • Suitable beta hydroxy acids include salicylic acid and derivatives thereof (including 5- n-octanoylsalicylic acid, salicylate, sodium salicylate, and willow extract), capryloyl salicylic acid, beta hydroxybutanoic acid, propionic acid, beta-hydroxy beata-methylbutyric acid, carnitine tropic acid, and trethocanic acid, and combinations of these.
  • the beta hydroxy acid in the chemical peel component of the skin-enhancing treatment excludes at least one of salicylic acid and derivatives thereof (including 5-n-octanoylsalicylic acid, salicylate, sodium salicylate, and willow extract), capryloyl salicylic acid, beta hydroxybutanoic acid, propionic acid, beta-hydroxy beata- methylbutyric acid, carnitine tropic acid, and trethocanic acid.
  • salicylic acid and derivatives thereof including 5-n-octanoylsalicylic acid, salicylate, sodium salicylate, and willow extract
  • capryloyl salicylic acid including 5-n-octanoylsalicylic acid, salicylate, sodium salicylate, and willow extract
  • capryloyl salicylic acid beta hydroxybutanoic acid
  • propionic acid beta-hydroxy beata- methylbutyric acid
  • carnitine tropic acid carnitine tropic acid
  • the chemical peel component of the skin-enhancing treatment includes a concentration of beta hydroxy acid in a range from about 0.1% up to and not more than about 2% of beta hydroxy acid, by weight, based on the total weight of the chemical peel component of the skin-enhancing treatment.
  • the chemical peel component of the skin-enhancing treatment includes up to and not more than about 2%, or about 1.9% of beta hydroxy acid.
  • the chemical peel component of the skin-enhancing treatment includes up to and not more than about 1% of beta hydroxy acid.
  • the amount of beta hydroxy acid present is not more than about 0.40% to about 0.50%.
  • the chemical peel component of the skin-enhancing treatment includes from about 0.1% to about 1% of beta hydroxy acid, or from about 0.2% to about 2.0%, or from about 0.1% to about 1.5%, or from about 0.2% to about 1.5%, or from about 0.3% to about 1.0%, or from about 0.35% to about 0.75%, or from about 0.4% to about 0.5%, or is about 0.45%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peel component of the skin-enhancing treatment.
  • beta hydroxy acid or from about 0.2% to about 2.0%, or from about 0.1% to about 1.5%, or from about 0.2% to about 1.5%, or from about 0.3% to about 1.0%, or from about 0.35% to about 0.75%, or from about 0.4% to about 0.5%, or is about 0.45%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peel component of the skin-enhancing treatment.
  • the at least one beta hydroxy acid is present in the chemical peel component of the skin-enhancing treatment from about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, to about 2.0 weight percent, including increments and all ranges and subranges therein and there between.
  • Phenylethyl Resorcinol may include use of a complementary composition comprising phenylethyl resorcinol.
  • Phenylethyl resorcinol functions a tyrosinase inhibitor.
  • the phenylethyl resorcinol when utilized in the chemical peel component of the skin-enhancing treatment effectively whiten skin and reduce skin tone unevenness. Phenylethyl resorcinol has not shown adverse effects in basic toxicological tests, including acute oral toxicity, mutagenicity, skin irritation, skin sensitization, and phototoxicity.
  • the amount of phenylethyl resorcinol present in the chemical peel component of the skin-enhancing treatment is from about 0.2% to about 2.0%, or from about 0.2% to about 1.5%, or from about 0.4% to about 1.0%, or from about 0.6% to about 0.9%, or from about 0.7% to about 0.8%, or from about 0.2% to about 0.8%, is about 0.75%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the chemical peel component of the skin-enhancing treatment.
  • the amount of phenylethyl resorcinol present is not more than about 0.2% to about 0.8%.
  • phenylethyl resorcinol when present in the chemical peel component of the skin-enhancing treatment, is present, by weight, based on the total weight of the chemical peel component of the skin-enhancing treatment, from about 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 to about 2.0 weight percent, including increments and ranges therein and there between.
  • the skin conditioning composition may be provided in a kit or other article of manufacture.
  • the sub compositions that are packaged are maintained as separate until the skin conditioning composition and the at least one complementary composition is intended to be applied to keratinous tissue, at which time they may be separately applied or may be applied together, or may be combined and mixed prior to application.
  • the skin conditioning composition is separate from the complementary composition until the skin conditioning composition is intended to be applied to keratinous tissue.
  • one sub composition includes at least the hydrogen peroxide and any additional optional oxidizing agent, and one sub composition includes at least the alkaline booster.
  • each of the sub compositions may include any one or more of the fatty compounds and any one or more of solvents, surfactants, polymers, actives, and other components.
  • any one or more of the fatty compounds and any one or more of solvents, actives and other components may be separately packaged from the other sub compositions, such that the article of manufacture may comprise more than two separate packages or package chambers.
  • the article of manufacture may be a packet with separate packages or chambers separated by a frangible seal between the chambers. In use, the seal is broken by the user to contact the separately packaged sub compositions and mix them prior to application onto the skin.
  • the article of manufacture may be a tube with dual chambers.
  • the article of manufacture may be a dual-chamber pump and the two parts can be mixed in after pumping out of the container.
  • the packaging is a single tube with a seal between the two components that is broken to mix.
  • the packaging can be a single container holding a suspension of encapsulated material that is mixed/broken to disperse and mix.
  • the packaging is otherwise sufficient to retain the skin conditioning composition separate from the complementary composition until the skin conditioning composition is intended to be applied to keratinous tissue.
  • the one or both of the first and second parts may be delivered by spray application, or other applicator selected from a pump, or brush.
  • a composition of the system for forming a continuous film mask is in a form including a suspension, lotion, cream, serum, essence, gel, stick, spray, ointment, paste, foam, mousse, cream, wipe, patch, strip, film- forming product.
  • compositions and systems as described in the representative embodiments herein are selected from commercially available materials, including, as shown in the exemplified embodiments herein below, for example: Urea, glycine, serine, Latic acid, sodium lactate, triacetin, and triethyl citrate.
  • Table 2 Raw Materials
  • Example 2 Inventive Compositions and Systems
  • Five exemplary embodiments of the inventive composition are shown in Table 3.
  • Table 3 Inventive Composition
  • Example 3 Effect of amino acid on pH
  • the effect of amino acid (glycine) on pH was evaluated in compositions with 20% urea and with 40% urea. Stability of pH was not possible at either amount of urea when the amount of amino acid (glycine) was below 5%.
  • the pH was stabilized in a range from about 5.5 to about 6.5 above 5% and up to about 9% amino acid (glycine).
  • the pH was stable in a range from about 5.5 to about 6.5 but the skin conditioning composition was unstable as evidenced by crystal formation.
  • Example 4 Effect of buffer and amino acid (glycine or serine at 5%) on pH and stability
  • the effect of buffer on pH and stability was evaluated in compositions with 20% urea and with 40% urea after a period of 4 weeks at 45 o C and at 4 o C.
  • the pH remained stable in a range from between 5.5 and 6.5, with overall better performance with buffer (a change of less than 10% over the time period).
  • Similar results were obtained with serine, in a higher average range from about 7 to just above pH 7.5.
  • Example 5 Effect of 5% Proline vs 3% and 5% Glycine on pH at varying temperatures over time
  • the amino acid was substituted to evaluate the effect of % Proline vs 3% and 5% Glycine on pH at varying temperatures over time in (with 40% urea). In all cases the starting pH was about 5.5.
  • Example 6 Effect of triacetin
  • Triacetin was varied to evaluate its effect on pH and stability. Triacetin was varied at 0.1%, 0.4% and 0.7% and substituted with 1.2% and 2.4% triethyl citrate, and each sample was evaluated at 4 o C, 25 o C, 37 o C and 45 o C. In all examples, the results were comparable, with all samples showing a nominal change in pH at 4 o C , 25 o C and 37 o C, and all samples showing a change of about 10% to about 15% in pH at 45 o C.
  • Example 7 Effect of glycols on pH and stability
  • the effect of glycols on the pH and stability (from crystallization) of the composition of INV #1 with 40% urea and 5% amino acid (glycine) was varied in glycol content and glycol composition (glycerin and/or propylene glycol).
  • Two samples of each formulation were tested, and the formulations included from 0% to 7% glycol (glycerin or propylene glycol), and glycerin:propylene glycol in ratios from 4:1 to 1:4.
  • the pH study all samples were maintained for 8 weeks, at 25 o C and 45 o C. In all cases, the pH remained stable in a range from about 5.9 to about 6.9.
  • Example 6 Effect of Urea vs hydroxyethyl urea on peel efficacy using a hydroxy acid
  • HEU hydroxyethyl urea
  • inventive compositions INV #1 (40% urea), INV #1 (a) having 23% urea, INV #1 (b) having 23% HEU, and INV #1 (c) having 40% HEU. Studies were conducted with each of the tested compositions to evaluate effect of the compositions on the stratum corneum.
  • DSC differential scanning calorimetry
  • each test composition was applied first to skin without rinsing, followed by application of a hydroxy-acid based peel composition in a moisturizer form. The results are shown in FIG 1, FIG 2 and FIG 3.
  • the studies revealed that increased amounts of each of urea and hydroxyethyl urea resulted in increased desquamation as compared to use of the peel moisture alone, the desquamation evidenced by stratum corneum disorganization.
  • the compositions with urea outperformed those with HEU, and in particular, the 23% urea form performed as well as the 40% HEU form.
  • “At least one,” as used herein, means one or more and thus includes individual components as well as mixtures/combinations.
  • the transitional terms “comprising”, “consisting essentially of” and “consisting of”, when used in the appended claims, in original and amended form, define the claim scope with respect to what unrecited additional claim elements or steps, if any, are excluded from the scope of the claim(s).
  • the term “comprising” is intended to be inclusive or open-ended and does not exclude any additional, unrecited element, method, step or material.
  • the term “consisting of” excludes any element, step or material other than those specified in the claim and, in the latter instance, impurities ordinarily associated with the specified material(s).
  • weight or amount as used herein with respect to the percent amount of an ingredient refers to the amount of the raw material comprising the ingredient, wherein the raw material may be described herein to comprise less than and up to 100% activity of the ingredient. Therefore, weight percent of an active in a composition is represented as the amount of raw material containing the active that is used, and may or may not reflect the final percentage of the active, wherein the final percentage of the active is dependent on the weight percent of active in the raw material.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

Une composition de traitement de la peau comprend un système de support ayant une phase aqueuse comprenant d'environ 20 % à environ 40 % d'urée ou d'un dérivé de celle-ci, en poids de la composition ; au moins un acide aminé ; au moins l'un parmi la triacétine ou le citrate de triéthyle ; et, facultativement : un système tampon ayant un pH se situant dans une plage allant d'environ 4,0 à environ 6,0 et un ou plusieurs ingrédients supplémentaires, chacun étant présent dans la phase aqueuse de la composition de traitement de la peau ou dans une seconde phase. La composition de traitement de la peau peut avoir un pH qui est inférieur à environ 7. L"invention concerne une méthode d'amélioration de l'efficacité d'un agent actif de soin de la peau qui comprend l'application, dans n'importe quel ordre, d'au moins une composition de traitement de la peau ; et d'une seconde composition qui comprend un ou plusieurs agents actifs de la peau qui ne sont pas présents dans la composition de traitement de la peau. La composition complémentaire est une composition de peeling sans rinçage ou avec rinçage de la peau comprenant au moins un hydroxyacide. Les compositions peuvent être fournies en tant qu'article de fabrication qui comprend au moins des première et seconde compositions contenues séparément.
PCT/IB2022/059185 2021-09-30 2022-09-27 Compositions à haute teneur en urée et méthodes de renforcement d'agents actifs WO2023052995A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US202163250577P 2021-09-30 2021-09-30
US202163250586P 2021-09-30 2021-09-30
US63/250,586 2021-09-30
US63/250,577 2021-09-30
FR2113556A FR3130145A1 (fr) 2021-12-15 2021-12-15 Composition cosmétique de conditionnement de la peau à haute teneur en urée
FRFR2113553 2021-12-15
FRFR2113556 2021-12-15
FR2113553A FR3130147A1 (fr) 2021-12-15 2021-12-15 Composition de rajeunissement de la peau à forte concentration en urée pour renforcer les actifs de soin de la peau

Publications (1)

Publication Number Publication Date
WO2023052995A1 true WO2023052995A1 (fr) 2023-04-06

Family

ID=83688821

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2022/059185 WO2023052995A1 (fr) 2021-09-30 2022-09-27 Compositions à haute teneur en urée et méthodes de renforcement d'agents actifs

Country Status (1)

Country Link
WO (1) WO2023052995A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59134772A (ja) * 1983-01-20 1984-08-02 Shiseido Co Ltd 尿素の安定化法
FR2854070A1 (fr) * 2003-04-24 2004-10-29 Oreal Methode de peeling cosmetique
EP1743623A2 (fr) * 2005-07-13 2007-01-17 L'oreal Utilisation de composés d'urée pour favoriser la desquamation
US7999008B2 (en) 2005-07-13 2011-08-16 L'oreal Urea compounds that promote desquamation
CN112515992A (zh) * 2020-12-08 2021-03-19 上海家化联合股份有限公司 包含柠檬酸三乙酯和甘氨酸的稳定组合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59134772A (ja) * 1983-01-20 1984-08-02 Shiseido Co Ltd 尿素の安定化法
FR2854070A1 (fr) * 2003-04-24 2004-10-29 Oreal Methode de peeling cosmetique
EP1743623A2 (fr) * 2005-07-13 2007-01-17 L'oreal Utilisation de composés d'urée pour favoriser la desquamation
US7999008B2 (en) 2005-07-13 2011-08-16 L'oreal Urea compounds that promote desquamation
CN112515992A (zh) * 2020-12-08 2021-03-19 上海家化联合股份有限公司 包含柠檬酸三乙酯和甘氨酸的稳定组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD [online] MINTEL; 19 July 2021 (2021-07-19), ANONYMOUS: "Ultra K Anti-Roughness Cream", XP055941399, retrieved from https://www.gnpd.com/sinatra/recordpage/8870869/ Database accession no. 8870869 *

Similar Documents

Publication Publication Date Title
ES2621922T3 (es) Composición cosmética que comprende un compuesto de ácido cucúrbico y una inulina hidrófoba
WO2021126667A1 (fr) Tensioactifs destinés à être utilisés dans des produits de soins personnels et cosmétiques
FR3030255A1 (fr) Composition de coloration comprenant une base d'oxydation para-phenylenediamine, un epaississant polysaccharide dans un milieu riche en corps gras
FR3117803A1 (fr) Composition comprenant des gélifiants aqueux, un tensioactif et de l’acide ascorbique
FR3030234A1 (fr) Composition de coloration comprenant une base d'oxydation para-phenylenediamine, un tensio actif non ionique dans un milieu riche en corps gras
FR3117799A1 (fr) Composition comprenant des gélifiants aqueux, un tensioactif, des huiles, des charges et de l’acide ascorbique
FR3058890A1 (fr) Agent de stabilisation des fibres kératiniques comprenant des hétérocyles à 5 cycles
KR20220118489A (ko) 5 중량% 내지 30 중량% 범위의 함량으로 하나 이상의 폴리올을 포함하는 수성 상 및 비실리콘 오일을 포함하는 오일 상을 포함하는 2-상 조성물
US20230095495A1 (en) Skin conditioning composition with high concentration of urea to boost the skincare actives
WO2023052995A1 (fr) Compositions à haute teneur en urée et méthodes de renforcement d'agents actifs
US20230108443A1 (en) Cosmetic skin conditioning composition with high urea content
EP4178681A1 (fr) Tensioactifs acides aminés ramifiés pour produits de soins personnels et produits cosmétiques
FR3054129A1 (fr) Agents de protection des cheveux et procede de coloration de cheveux oxydatifs a effet de lumiere amélioree
FR3105735A1 (fr) Composition comprenant de l’acide ascorbique
FR3058889A1 (fr) Agents alcalins pour compositions eclaircissantes de cheveux comprenant des agents oxydants et des esters d'acide carboxylique comme réseaux de kératine
US11660261B2 (en) High viscosity gel cleansing compositions
US20220168210A1 (en) High foaming cleansing composition
FR2926981A1 (fr) Composition cosmetique comprenant un copolumere vinylformamide/vinylformamine et un polymere cationique
WO2016102402A1 (fr) Composition aqueuse comprenant un composé 4-(hétérocycloalkyl)-benzene-1,3-diol, un monoalcool en c2-c4 et un glycol
WO2016102400A1 (fr) Composition comprenant un composé 4-(hétérocycloalkyl)-benzene-1,3-diol et un solvant particulier
WO2022115744A2 (fr) Compositions de nettoyage de gel à viscosité élevée
FR3046066A1 (fr) Composition a base d’acide spiculisporique
KR20170143097A (ko) 피토스핑고신 유도체를 포함하는 기능성 화장료 조성물
FR3131692A1 (fr) Composition comprenant une huile, un alcool soluble dans l’eau et une gomme de guar non ionique
FR3139718A1 (fr) Compositions et procédés pour modifier la couleur des cheveux.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22786504

Country of ref document: EP

Kind code of ref document: A1