WO2023047656A1

WO2023047656A1 - Infusion pump and infusion pump control method

Info

Publication number: WO2023047656A1
Application number: PCT/JP2022/012093
Authority: WO
Inventors: 勝平佐々木
Original assignee: テルモ株式会社
Priority date: 2021-09-24
Filing date: 2022-03-16
Publication date: 2023-03-30

Abstract

An infusion pump 1 for delivering a pre-set dosage of a fluid infusion via an infusion tube 30, said infusion pump 1 being equipped with a control unit 11 for obtaining a captured image of the infusion tube 30 which was captured by a two-dimensional sensor, analyzing the captured image, detecting the amount of bubbles contained in the fluid infusion, and correcting the dosage on the basis of the detected amount of bubbles.

Description

Infusion pump and control method for infusion pump

The present disclosure relates to an infusion pump and a method for controlling the infusion pump.

An infusion pump is a device that delivers infusions such as drug solutions into the patient's body through an infusion tube. In an infusion pump, it is important to accurately deliver a prescribed dose of infusion into the body. Patent Literature 1 describes a technique related to detecting the delivery amount of an infusion solution.

JP 2019-217072 A

However, in the configuration of the conventional infusion pump, even though the infusion solution contains air bubbles, the infusion solution containing air bubbles is administered only at the dosage set by the user. In some cases, the total amount of infusion fluid received was insufficient for the set dose. In particular, in the configuration of a conventional infusion pump, minute air bubbles that have no effect on the human body may be administered into the patient's body without being detected. There could be cases where the amount was insufficient for the set value. Therefore, conventional infusion pumps have room for improvement in controlling the amount of infusion with high accuracy.

An object of the present disclosure is to provide an infusion pump and a control method for the infusion pump that can control the dose of the infusion with higher accuracy.

An infusion pump according to an embodiment of the present disclosure is an infusion pump that delivers a preset dose of infusion through an infusion tube, and acquires an image of the infusion tube captured by a two-dimensional sensor. and a control unit that analyzes the photographed image, detects the volume of air bubbles contained in the infusion solution, and corrects the dosage based on the detected air volume of the air bubbles.

In one embodiment, the control unit corrects the dose so as to increase the infusion delivering an additional dose equal to the amount of air bubbles detected.

As one embodiment, when a first volume of bubbles is detected when the infusion solution is delivered during the first period, the control unit controls the second period following the first period. The infusion dose preset for period 2 is corrected by incrementing the same additional dose as the first bubble volume.

As one embodiment, when bubbles of the first bubble volume are detected when the infusion solution is delivered in the first period, the control unit preliminarily determines the dose amount of the infusion solution that can be administered in the same period. The preset dose of the infusion solution for the second period is increased within a range not exceeding the set upper limit.

As one embodiment, when a first volume of air bubbles is detected when the infusion solution is delivered in the first period, the controller controls, in a plurality of second periods subsequent to the first period, The dose of the transfusion solution preset for each of the plurality of second periods is corrected by increasing the amount of the first bubble divided by the number of the plurality of second periods.

As one embodiment, the control unit detects the amount of air bubbles contained in the infusion solution based on the light intensity in the area occupied by the infusion tube in the captured image.

As one embodiment, the control unit detects the amount of air bubbles contained in the infusion solution based on the boundary between the infusion solution and the air bubbles in the area occupied by the infusion tube in the captured image.

A control method for an infusion pump according to an embodiment of the present disclosure is a control method for an infusion pump including a control unit that delivers a preset dose of infusion through an infusion tube, wherein the control unit obtaining a photographed image of the infusion tube photographed by a two-dimensional sensor; analyzing the photographed image to detect the amount of air bubbles contained in the infusion; compensating the dose based on the amount.

According to one embodiment of the present disclosure, it is possible to control the dosage of the infusion with higher accuracy.

1 is a front view showing a configuration example of an infusion pump according to one embodiment; FIG. FIG. 2 is a perspective view showing a configuration example of the infusion cartridge of FIG. 1; FIG. 2 is a diagram schematically showing air bubbles in an infusion solution flowing through the infusion tube of FIG. 1; FIG. 2 is a diagram schematically showing air bubbles in an infusion solution flowing through the infusion tube of FIG. 1; FIG. 2 is a diagram schematically showing air bubbles in an infusion solution flowing through the infusion tube of FIG. 1; 4 is a bar graph schematically showing the operation of the infusion pump according to one embodiment to correct the dose of the infusion. 4 is a graph showing an example of changes in the amount of infusion corrected by the infusion pump according to one embodiment. 4 is a flowchart showing an example of correction processing executed by an infusion pump according to one embodiment; 4 is a bar graph schematically showing the operation of the infusion pump according to one embodiment to correct the dose of the infusion. 4 is a graph showing an example of changes in the amount of infusion corrected by the infusion pump according to one embodiment. 4 is a flowchart showing an example of correction processing executed by an infusion pump according to one embodiment;

An embodiment of the present disclosure will be described below with reference to the drawings. In each drawing, parts having the same configuration or function are given the same reference numerals. In the description of the present embodiment, overlapping descriptions of the same parts may be appropriately omitted or simplified.

(Configuration of infusion pump)
FIG. 1 is a front view showing a configuration example of an infusion pump 1 according to an embodiment of the present disclosure. As shown in FIG. 1 , the infusion pump 1 includes a pump body 10 and an infusion cartridge 20 . The pump main body 10 includes a control section 11 , a storage section 12 , an air bubble detection section 13 , an input section 14 , a liquid feeding section 15 , an output section 16 and a battery 17 . The infusion pump 1 shown in FIG. 1 may be used as, for example, a PCA (Patient Controlled Analgesia) pump, but its application is not particularly limited. The infusion pump 1 of this embodiment is, for example, a PCA pump in which the pump body 10 can be reused by replacing the disposable infusion cartridge 20 . The infusion pump 1 is not limited to the PCA pump. The infusion pump 1 may be a common infusion pump, syringe pump, nutrition pump, blood pump, or insulin pump. A general infusion pump is, for example, a pump that does not include an infusion cartridge 20 and pushes an infusion tube 30 connected to an infusion bag outside the pump to deliver the infusion in the infusion bag. The infusion pump 1 detects air bubbles in the infusion tube 30 from the photographed image of the infusion tube 30, and corrects the preset infusion dose based on the information on the air bubbles, thereby controlling the infusion dose with high accuracy. make it possible to

As shown in FIG. 1, on the front of the pump main body 10, an output section 16 that displays various information and an input section 14 in which operation switches are arranged are arranged. The output unit 16 is, for example, a display that displays the liquid feeding speed, the cumulative dose, and the like. The output unit 16 may be, for example, a liquid crystal screen with a touch panel for setting the liquid feeding speed and the like. In addition, the output unit 16 may be any device capable of outputting information to the user, and includes at least one of a speaker for outputting a sound such as an alarm, a vibrator that vibrates, and a lamp. good too. The operation switch of the input unit 14 is, for example, a fast-forward switch that enables liquid feeding at a liquid feeding speed higher than the set liquid feeding speed (mL/h) while being pressed by the user. A start switch for starting liquid feeding, a stop switch for forcibly stopping liquid feeding when pressed, and a power switch for instructing ON/OFF of the power supply of the pump main body 10 may be used. However, the input unit 14 may have other configurations in place of or in addition to these switches as long as the user can input information. For example, the input unit 14 may be configured as a touch panel.

The liquid feeding section 15 sandwiches the infusion tube 30 of the infusion cartridge 20 between the tube receiving section 24 (see FIG. 2) of the infusion cartridge 20 to be attached, and causes the infusion in the infusion tube 30 to flow from the upstream side of the flow path. Send it to the downstream side of the road. The liquid sending unit 15 includes a plurality of fingers 151 and a driving unit that drives each finger 151 . The plurality of fingers 151 are arranged on the side of the pump body 10 facing the tube receiving portion 24 located on the side of the infusion cartridge 20 . The plurality of fingers 151 are arranged along the extending direction (x direction) of the infusion tube 30 . Each finger 151 is driven by the driving section so as to reciprocate in a direction (z direction) facing the tube receiving section 24 of the infusion cartridge 20 . For example, the drive section may have a configuration that converts the power of the motor into reciprocating movement of each finger 151 in the z direction using a mechanical component such as a cam. By moving each finger 151 closer to the infusion cartridge 20 , the infusion tube 30 is sandwiched between each finger 151 and the tube receiving portion 24 . As a result, the infusion tube 30 is closed. The drive unit sequentially drives the fingers 151 from the flow channel upstream side toward the flow channel downstream side in the extending direction (x direction) of the infusion tube 30 . As a result, the infusion tube 30 is sequentially compressed and closed from the upstream side of the flow path toward the downstream side of the flow path, and performs peristaltic motion. Therefore, the infusion solution in the infusion tube 30 can be delivered from the upstream side of the flow path toward the downstream side of the flow path.

The control unit 11 is one or more processors and controls the operation of each component of the pump body 10 . The control unit 11 is realized by a dedicated processor that specializes in processing such as sending infusion into the patient's body and inputting and outputting information with the user, but is realized by a general-purpose processor such as a CPU (Central Processing Unit). may be Control unit 11 may include one or more dedicated circuits, or one or more processors may be replaced by one or more dedicated circuits in control unit 11 . The dedicated circuit is, for example, an FPGA (Field-Programmable Gate Array) or an ASIC (Application Specific Integrated Circuit). The control section 11 controls each section of the pump body 10 and executes information processing related to the operation of the infusion pump 1 .

The storage unit 12 includes arbitrary storage modules including, for example, RAM (Random Access Memory) and ROM (Read-Only Memory). The storage unit 12 stores arbitrary information used for the operation of the infusion pump 1 . For example, the storage unit 12 may store various programs such as a system program and an application program, information on the dose of the infusion solution, and various data such as a photographed image of the infusion tube 30 .

The air bubble detection unit 13 photographs the infusion tube 30 and detects air bubbles present in the infusion in the infusion tube 30 . The air bubble detection unit 13 includes a light emitting unit that emits an imaging light flux having a specific wavelength to the infusion tube 30, and a two-dimensional sensor that photoelectrically converts the light flux that passes through the infusion tube 30 and forms an image to form a captured image. (camera) may be provided. The two-dimensional sensor of the air bubble detection unit 13 may be configured by, for example, a CMOS (Complementary Metal-Oxide Semiconductor) image sensor, a CCD (Charge Coupled Device) image sensor, or the like. When photographing the infusion tube 30, the light emitting unit can emit light of any wavelength as a light flux, but may emit infrared light, for example. The two-dimensional sensor may be configured by a sensor capable of detecting a light flux of a specific wavelength such as infrared light wavelength. By photographing using infrared light instead of visible light, it is possible to suppress disturbance of the photographed image even if illumination light used in the room enters the infusion pump 1 . In addition, since infrared light has relatively low energy, it is possible to suppress the influence on the infusion solution. Furthermore, there is the advantage that even if infrared light leaks out of the apparatus, it is difficult for the human eye to perceive it.

The battery 17 stores power for operating the infusion pump 1 . The battery 17 may be composed of a lithium ion battery. Electric power for operating the infusion pump 1 may be supplied not only from the battery 17 but also from a commercial power source, for example.

The pump body 10 is not limited to the configuration of this embodiment. As with other infusion pumps, the pump main body 10 includes a control unit 11, a storage unit 12, an air bubble detection unit 13, an input unit 14, a liquid delivery unit 15, an output unit 16, and a battery 17, as well as, for example, an occlusion sensor. You may provide a part etc. The pump body 10 may include components other than the components described above, or may be replaced with components having equivalent functions. Further, as described above, in the example of the present embodiment, the liquid feeding section 15 presses the infusion tube 30 with the plurality of fingers 151, but the liquid feeding section 15 can feed the infusion in the infusion tube 30. If so, it may have a configuration different from the finger 151 .

FIG. 2 is a perspective view showing a configuration example of the infusion cartridge 20 of FIG. The infusion cartridge 20 includes a storage portion 22 , a filling port 23 and a tube receiving portion 24 . An infusion tube 30 is attached to the infusion cartridge 20 to supply the infusion from the inside of the infusion bag. Alternatively, however, the infusion tube 30 may be attached directly to the infusion bag.

The storage unit 22 accommodates an infusion bag filled with an infusion. The filling port 23 , the tube receiving portion 24 , and the infusion tube 30 are provided on the side of the housing portion 22 facing the pump body 10 when the infusion cartridge 20 is attached to the pump body 10 . The filling port 23 is connected to an infusion bag housed inside the housing portion 22 and connected to an infusion tube 30 from the outside of the housing portion 22 . The tube receiving portion 24 holds the infusion tube 30 by sandwiching the infusion tube 30 with the pump main body 10 . The tube receiving portion 24 may include, for example, a groove into which the infusion tube 30 is fitted. With such a configuration, the infusion solution in the infusion bag stored in the storage part 22 can be delivered to the outside through the infusion tube 30 .

(Summary of dose correction)
Next, the outline of the process of correcting the dose of the infusion by the infusion pump 1 will be described. 3A to 3C are diagrams schematically showing air bubbles in the infusion solution flowing through the infusion tube 30 of FIG. 1. FIG. 3A to 3C all show how the infusion 35 flows through the infusion tube 30. FIG. In FIG. 3A , in the infusion tube 30 , there is a bubble 31 that is occupied only by air for a length L in the longitudinal direction of the infusion tube 30 . Assuming that the radius of the channel in the infusion tube 30 is r, the volume V ₁ of the air bubble 31 is expressed by the following equation (1).
[Formula 1]
V ₁ =π×r ² ×L
Therefore, when the bubble detector 13 detects the bubble 31, the infusion pump 1 may correct the dose of the infusion by the volume _V1 .

In FIG. 3B, within the infusion tube 30 there is a spherical bubble 32 filled with air of radius s. The volume V ₂ of the bubble 32 is represented by the following Equation 2.
[Formula 2]
V ₂ = 4/3 x π x s ³
Therefore, when the air bubble detector 13 detects the air bubble 32, the infusion pump 1 may correct the dose of the infusion liquid by the volume _V2 .

3A and 3B, in the region occupied by the infusion tube 30 in the captured image, when the boundary between the infusion 35 and the bubbles can be clearly obtained, the infusion pump 1 displays the image showing the boundary as described above. Based on this, the amount of air bubbles contained in the infusion solution 35 may be detected. On the other hand, if the boundary between the infusion 35 and the bubbles cannot be clearly obtained, the infusion pump 1 is included in the infusion 35 based on the light intensity (for example, luminance, illuminance, etc.) in the area occupied by the infusion tube 30 in the captured image. The bubble volume of bubbles may be detected. In FIG. 3C , in the infusion tube 30 , there are many minute bubbles 33 whose radii cannot be detected by the two-dimensional sensor of the bubble detection section 13 . Generally, in the photographed image of the infusion tube 30, the light intensity of the portion where the infusion 35 containing the air bubbles 33 is present is significantly different from the light intensity of the portion where only the infusion 35 is present. Therefore, in this embodiment, the average brightness is used as the light intensity, and the infusion pump 1 can specify the amount of air bubbles 33 mixed in the infusion 35 based on the average brightness in the area occupied by the infusion tube 30 . For example, the infusion pump 1 obtains in advance, for example, by machine learning, information indicating the correspondence relationship between the average brightness in the area occupied by the infusion tube 30 in the captured image and the volume of the air bubbles 33 contained in the unit amount of the infusion 35, and stores the information in a table. It may be stored in a format such as The infusion pump 1 obtains the volume _V3 of the air bubbles 33 mixed in the infusion 35 from the photographed image of the infusion tube 30 based on the information of such a correspondence relationship, and corrects the dose of the infusion by the volume _V3 . good too. As described above, when the boundary between the infusion 35 and the bubbles is not clear in the captured image, the infusion pump 1 calculates the amount of bubbles mixed in the infusion 35 based on the average brightness of the area occupied by the infusion tube 30 in the captured image. Obtained, the dose of the infusion 35 can be corrected.

(Example 1)
Next, the process according to the first embodiment, in which the infusion pump 1 corrects the dose of the infusion, will be described. FIG. 4 is a bar graph schematically showing the operation of the infusion pump 1 according to Example 1 for correcting the dose of the infusion. In FIG. 4, periods T1 to T6 indicate periods during which the infusion is administered. The height of the graph in periods T1 to T6 indicates the dose of the infusion solution in each period. Here, one administration is performed over a certain period of time, for example, 5 to 30 minutes. Each of the periods T1 to T6 is a time with a certain width, such as 13:00 to 13:30.

In the example of FIG. 4, in each of the period T1 and the periods T4 to T6, the infusion solution is administered in a dose preset by the user without air bubbles. During the period T2, air bubbles are mixed in, and the infusion solution is not administered for the amount of the air bubbles. Therefore, in the period T3, the same volume of the infusion liquid as the bubbles mixed in the infusion liquid in the period T2 is additionally administered. In this way, when the infusion pump 1 fails to administer the infusion solution to be administered in a certain period due to air bubbles, etc., the infusion pump 1 additionally administers the same volume of the infusion solution as the entrained air bubbles in the next period. Therefore, the infusion pump 1 can inject into the patient's body an amount of infusion set in advance by the user as a whole, even if air bubbles occur during the liquid transfer. In addition, since the infusion pump 1 immediately corrects the volume of the generated air bubbles upon detection of the air bubbles, it is possible to quickly correct the dose of the infusion solution.

The infusion pump 1 supplies the infusion solution for which an upper limit value (limit value) of the amount that can be administered in one process is set, within a range not exceeding the upper limit value, in the period following the period in which air bubbles are detected. Dosage corrections may be made. If administration of the additional dose of infusion is still not completed, the infusion pump 1 may further correct the dose of the infusion within the range not exceeding the upper limit value in the next period and thereafter. In this way, the infusion pump 1 corrects the dose of the infusion within a range not exceeding the upper limit of the dose until the administration of the additional dose corresponding to the amount of the detected air bubbles is completed. you can go Therefore, even if an upper limit is set for the dose, the infusion pump 1 supplies the patient with the dose preset by the user without exceeding the upper limit of the dose for each period. It can be administered into the body. In addition, for example, when the infusion pump 1 discovers air bubbles during administration during the period T2, the infusion pump 1 immediately acquires an additional dose, and does not exceed the upper limit of the amount that can be administered during the period T2. Additional doses of fluid may be administered. As a result, the infusion pump 1 can immediately administer the dose of the infusion set in advance by the user even if air bubbles occur during the liquid transfer. Also, FIG. 4 shows an example in which the dosage of the infusion solution preset for each of the periods T1 to T6 is the same, but the dosage of the infusion solution may differ depending on the period.

FIG. 5 is a graph showing an example of changes in cumulative values of doses (target dose, actual dose) corrected by the infusion pump 1 according to Example 1. FIG. The target dose is a target cumulative value of the dose of the infusion solution preset by the user. The actual dose is the cumulative value of the dose of the infusion solution actually administered to the patient. In FIG. 5, the horizontal axis indicates time, and the vertical axis indicates the cumulative amount of the infusion administered to the patient. The period from time t0 to t1 in FIG. 5 may correspond to period T1 in FIG. 4, for example. The period from time t2 to t3 may correspond to period T2, for example. The period from time t4 to t5 may correspond to period T3, for example. The period from time t6 to t7 may correspond to period T4, for example. The periods T1, T2, . . . T6, . , times t5 and t6, and times t7 and t8 are continuous, that is, the graph omits the periods of times t1 to t2, times t3 to t4, times t5 to t6, and times t7 to t8.

In the example of FIG. 5, no air bubbles are generated during the period from time t0 to t1, and the infusion is administered at a constant flow rate. The flow rate is the amount of infusion delivered by the infusion pump 1 per unit time. During the period from time t2 to t3, air bubbles are generated and the administration of the infusion solution is temporarily interrupted. Therefore, in the period from time t4 to t5, the infusion pump 1 initially administers the infusion at a normal flow rate, and at time t5, an additional dose of the infusion having the same volume as the bubbles generated in the period from time t2 to t3. are sending out. The infusion pump 1 pumps the infusion at a higher than normal flow rate throughout the period of time t4-t5, rather than pumping an additional dose of infusion in bulk at the end of the period of time t4-t5. , the infusion may be delivered in increments of additional doses. This makes it possible to reduce fluctuations in the total amount of infusion per unit time and reduce the burden on the patient. During the period from time t6 to t7, no bubbles are generated, and the infusion pump 1 administers the infusion at a constant flow rate.

FIG. 6 is a flow chart showing an example of correction processing executed by the infusion pump 1 according to the first embodiment. The operation of the infusion pump 1 described with reference to FIG. 6 corresponds to one control method of the infusion pump 1 according to the first embodiment. The operation of each step in FIG. 6 is executed under the control of the control section 11 of the pump main body 10 . As a premise for the following processing, a priming operation is performed in advance to fill the infusion tube 30 connected to the infusion bag housed inside the storage section 22 with the infusion liquid, and the primed infusion tube 30 and the infusion cartridge 20 are connected to the pump main body 10. is properly attached to the

At step S1 in FIG. 6, the control unit 11 causes the air bubble detection unit 13 to start detecting air bubbles in the infusion tube 30 . Specifically, the control unit 11 activates the two-dimensional sensor of the air bubble detection unit 13 so that air bubbles can be detected.

In step S2, the control unit 11 starts liquid feeding. A liquid feeding amount is set in advance via the input unit 14, and the control unit 11 controls the liquid feeding unit 15 so as to feed the set amount of the infusion liquid. Thereafter, the control unit 11 repeats the processing of steps S3 to S7 at regular time intervals (for example, 1 second to 30 minutes).

In step S3, the control unit 11 determines whether or not the set amount of infusion has been administered. If the administration has been completed (Yes in step S3), the control unit 11 ends the processing of the flowchart, otherwise (No in step S3), the process proceeds to step S4.

In step S4, the control unit 11 determines whether or not the air bubble detection unit 13 has detected air bubbles. If an air bubble is detected (Yes in step S4), the controller 11 proceeds to step S5, otherwise (No in step S4), it proceeds to step S3 to continue liquid transfer.

In step S5, the control unit 11 measures the amount of air bubbles detected. For example, when the controller 11 detects an air bubble having a length L in the longitudinal direction of the infusion tube 30 as shown in FIG. For example, as shown in FIG. 3B, the control unit 11 may measure the amount of air bubbles using Equation 2 when spherical air bubbles having a radius of s are detected. For example, when a large number of minute bubbles 33 are detected as shown in FIG. 3C, the controller 11 may measure the amount of bubbles based on the average brightness of the portion inside the infusion tube 30 in the captured image.

In step S6, the control unit 11 determines whether or not the amount of air bubbles detected in step S5 exceeds a predetermined amount, which is a predetermined threshold. The predetermined amount is set in the infusion pump 1 in advance by the user. If it exceeds the predetermined amount (Yes in step S6), the controller 11 proceeds to step S8, otherwise (No in step S6), it proceeds to step S7.

In step S7, the control unit 11 administers an additional dose of the transfusion that is the same as the amount of air bubbles measured in step S5. FIG. 6 shows the process of administering the same amount of infusion fluid as the amount of detected air bubbles in the same period immediately after air bubbles are detected, as described with reference to FIGS. Then, the infusion pump 1 may administer additional doses of infusion after the next period. When administering an additional dose of infusion solution after the next period, the infusion pump 1 stores the detected bubble amount in the storage unit 12, and reads out the bubble amount stored in the storage unit 12 in the next period. , the dosage may be corrected. Then, the control unit 11 returns to step 3.

In step S8, the control unit 11 issues an alarm from the output unit 16 to notify the user that bubbles exceeding a predetermined amount have been issued. Specifically, the control unit 11 may display a warning on the display illustrated in FIG. 1 or output a warning sound from a speaker. Then, the control unit 11 ends the processing of the flowchart.

As described above, the infusion pump 1 delivers a preset dose of infusion via the infusion tube 30 . Here, the infusion pump 1 acquires a photographed image of the infusion tube 30 photographed by the air bubble detection unit 13 having a two-dimensional sensor, analyzes the photographed image, and detects the amount of air bubbles contained in the infusion. , corrects the dose of the infusion solution based on the bubble volume of the detected bubbles. Therefore, even if air bubbles enter the infusion solution during feeding, the infusion pump 1 corrects the dose of the infusion solution according to the amount of air bubbles, so that a preset dose of the infusion solution can be administered. Therefore, according to the infusion pump 1, it is possible to control the dose of the infusion with higher accuracy.

In addition, the infusion pump 1 corrects the dose so as to increase the delivered infusion by the same additional dose as the amount of air bubbles detected. Therefore, even if air bubbles are mixed into the infusion solution during feeding, the dose of the infusion solution is increased according to the amount of air bubbles, so that the preset dose of the infusion solution can be administered without decreasing the dose of the infusion solution. be able to.

Further, when the infusion pump 1 detects the first amount of air bubbles when pumping out the infusion in the first period (for example, T2 in FIG. 4), the infusion pump 1 performs the second period ( For example, at T3) in FIG. 4, the pre-set infusion dose for the second period is corrected by incrementing it by the same additional dose as the first bubble volume. For example, the infusion pump 1 can quickly make up for the shortage of the infusion by correcting the dose for the period following the period in which air bubbles are detected. Further, when the infusion pump 1 corrects the dose in the second period in response to the detection of air bubbles in the first period, the infusion pump 1 sets a preset upper limit of the dose of the infusion that can be administered in the same period. The preset infusion dose for the second time period may be incremented without exceeding the value. By doing so, the infusion pump 1 can quickly compensate for the shortage of the infusion while protecting the safety of the patient.

(Example 2)
In the infusion pump 1 according to Example 1 described with reference to FIGS. 4 to 6, when air bubbles are detected in a certain period, the dose is corrected immediately during that period or the next period, but an additional dose of infusion is added. The administration may be spread out over multiple periods. The infusion pump 1 according to the second embodiment can suppress fluctuations in the dose by dispersing the administration of the additional dose of the infusion over a plurality of periods.

FIG. 7 is a bar graph schematically showing how the infusion pump 1 according to Example 2 corrects the dose of the infusion. As in FIG. 4, periods T1 to T6 indicate periods during which the infusion is administered. The height of the graph in periods T1 to T6 indicates the dose of the infusion solution in each period. As in FIG. 4, each of the periods T1 to T6 is a time with a certain width, such as 13:00 to 13:30.

In the example of FIG. 7, some air bubbles are mixed in the administration during period T1. In the administration of period T2, only air bubbles were generated and no infusion was administered. Therefore, in the periods T3 to T6, in addition to the normal dose, an additional dose of the infusion solution having the same volume as the air bubbles mixed in the infusion solution in the periods T1 and T2 is dispersed and additionally administered. As described above, when the infusion pump 1 cannot administer the infusion to be administered in a certain period due to air bubbles or the like, the infusion pump 1 disperses and additionally administers the infusion of the same volume as the entrained air in the next period or later. do. Therefore, even if air bubbles are generated during liquid feeding, the infusion pump 1 will administer the amount of the infusion liquid that could not be administered due to the air bubbles. It can be administered into the body. In addition, since the infusion pump 1 distributes and administers additional doses of the infusion over a plurality of periods, fluctuations in the dose can be suppressed, and the burden on the patient can be reduced. When additional doses of the infusion solution are administered separately over a plurality of periods, the amount of the additional infusion solution administered in each period may be the same in all periods, or may vary depending on the period.

FIG. 8 is a graph showing an example of changes in cumulative values of doses (target dose, actual dose) corrected by the infusion pump 1 according to the second embodiment. In FIG. 8, as in FIG. 5, the horizontal axis indicates time, and the vertical axis indicates the cumulative amount of infusion administered to the patient. As in FIG. 5, the period from time t0 to t1 in FIG. 8 may correspond to period T1 in FIG. 7, for example. The period from time t2 to t3 may correspond to period T2, for example. The period from time t4 to t5 may correspond to period T3, for example. The period from time t6 to t7 may correspond to period T4, for example. The periods T1, T2, . . . T6, . , times t5 and t6, and times t7 and t8 are continuous, that is, the graph omits the periods of times t1 to t2, times t3 to t4, times t5 to t6, and times t7 to t8.

In the example of FIG. 8, no bubbles are generated during the period from time t0 to t1, and the infusion is administered at a constant flow rate. During the period from time t2 to t3, air bubbles are generated and the administration of the infusion solution is temporarily stopped. Therefore, the infusion pump 1 initially administers the infusion at a normal flow rate during the period from time t4 to t5, and at time t5, pumps out the infusion with a volume that is about half the volume of the bubbles generated during the period from time t2 to t3. there is Further, the infusion pump 1 initially administers the infusion at a normal flow rate during the period from time t6 to t7, and at time t7, the amount of the infusion administered at time t5 is reduced due to the volume of air bubbles generated during the period from time t2 to t3. You are delivering the volume of the infusion minus the volume. The infusion pump 1 maintains its normal flow rate throughout the periods t4-t5 and t6-t7, rather than bulking up at the end of the periods t4-t5 and t6-t7. The infusion may be delivered at a flow rate greater than . As a result, fluctuations in the dose of the infusion solution per unit time can be reduced, and the burden on the patient can be reduced.

FIG. 9 is a flowchart showing an example of correction processing executed by the infusion pump 1 according to the second embodiment. The operation of the infusion pump 1 described with reference to FIG. 9 corresponds to one control method of the infusion pump 1 according to the second embodiment. The operation of each step in FIG. 9 is executed under the control of the control section 11 of the pump main body 10 . As a premise for the following processing, a priming operation is performed in advance to fill the infusion tube 30 connected to the infusion bag housed inside the storage section 22 with the infusion liquid, and the primed infusion tube 30 and the infusion cartridge 20 are connected to the pump main body 10. is properly attached to the

In step S11 of FIG. 9, the controller 11 causes the bubble detector 13 to start detecting bubbles in the infusion tube 30. The processing of step S11 is the same as that of step S1 in FIG.

In step S12, the control unit 11 starts liquid feeding. The processing of step S12 is the same as that of step S2 in FIG. Thereafter, the control unit 11 repeats the processing of steps S13 to S19 at regular time intervals (for example, 1 second to 30 minutes).

In step S13, the control unit 11 determines whether or not the set amount of infusion has been administered. If administration has been completed (Yes in step S13), the control unit 11 ends the processing of the flowchart, otherwise (No in step S13), the process proceeds to step S14.

In step S14, the control unit 11 determines whether or not the air bubble detection unit 13 has detected air bubbles. If bubbles are detected (Yes in step S14), the controller 11 proceeds to step S15; otherwise (No in step S14), the controller 11 proceeds to step S13 to continue liquid feeding.

In step S15, the control unit 11 measures the amount of air bubbles detected. The processing of step S15 is the same as that of step S5 in FIG.

In step S16, the control unit 11 determines whether or not the amount of air bubbles detected in step S15 exceeds a predetermined amount, which is a predetermined threshold. The processing of step S16 is the same as that of step S6 in FIG. If it exceeds the predetermined amount (Yes in step S16), the control section 11 proceeds to step S20, otherwise (No in step S16), it proceeds to step S17.

In step S17, the control unit 11 calculates the corrected number of injections N based on the amount of air bubbles measured in step S15. For example, based on the upper limit of the dose of the infusion in each period and the dose set in advance for each period, the control unit 11 determines the amount of the infusion in each period when an additional dose of the infusion is administered over a plurality of periods. The minimum number of administrations such that the total dose does not exceed the upper limit may be determined as the corrected number of administrations N.

In step S18, the control unit 11 determines whether or not the number of times correction administration has been performed is equal to or less than the number N of correction administrations. If the number is equal to or less than N (Yes in step S18), the control unit 11 proceeds to step S19, otherwise (No in step S18), returns to step S13.

In step S19, the control unit 11 administers an amount of infusion solution for correcting the amount of air bubbles measured in step S15 in N batches. FIG. 9 shows the process of administering additional doses of transfusion in N separate doses immediately during the same period when air bubbles are detected, but please refer to FIGS. As explained, the infusion pump 1 may administer additional doses of the infusion over multiple subsequent periods. When correcting the dose after the next period, the infusion pump 1 stores the detected amount of air bubbles and the amount of the infusion solution that has been administered in the storage unit 12. The volume and amount of infusion administered may be read to correct the dose. After finishing the correction divided into N times (No in step S18), the control unit 11 returns to step S13.

In step S20, the control unit 11 issues an alarm from the output unit 16 to notify the user that bubbles exceeding a predetermined amount have been issued. The processing of step S20 is the same as that of step S8 in FIG. Then, the control unit 11 ends the processing of the flowchart.

As described above, when the infusion pump 1 detects the first amount of air bubbles during the first period (for example, T1 and T2 in FIG. 7) while pumping out the infusion, the infusion pump 1 continues the first period. In a plurality of second periods (for example, T3 to T6 in FIG. 7), the amount of infusion solution set in advance for each of the plurality of second periods is Correct by incrementing by the number of additional doses divided. In this way, the infusion pump 1 distributes and administers additional doses of the infusion over a plurality of second periods. Therefore, the infusion pump 1 can keep fluctuations in the dose small while administering a preset dose of the infusion solution, thereby reducing the burden on the patient.

The present disclosure is not limited to the above-described embodiments. For example, multiple blocks shown in the block diagrams may be combined, or a single block may be divided. Instead of being performed in chronological order according to the description, multiple steps described in the flowcharts may be performed in parallel or in different orders, depending on the processing power of the device performing each step or as required. . Other modifications are possible without departing from the scope of the present disclosure.

1 infusion pump 10 pump main body 11 control unit 12 storage unit 13 air bubble detection unit 14 input unit 15 liquid delivery unit 16 output unit 17 battery 20 infusion cartridge 22 storage unit 23 filling port 24 tube receiving unit 30 infusion tube

Claims

An infusion pump that delivers a preset dose of infusion through an infusion tube,
Acquiring a photographed image of the infusion tube photographed by a two-dimensional sensor,
analyzing the captured image to detect the amount of air bubbles contained in the infusion;
correcting the dosage based on the amount of the detected air bubbles;
An infusion pump comprising a controller.
The infusion pump according to claim 1, wherein the control unit corrects the dose so as to increase the infusion delivered by an additional dose equal to the amount of air bubbles detected.
When a first amount of air bubbles is detected when the infusion solution is delivered during the first period, the control unit preliminarily controls the second period during the second period subsequent to the first period. 3. The infusion pump according to claim 1 or 2, wherein the set dose of the infusion is corrected by increasing it by an additional dose equal to the first bubble volume.
The control unit sets a preset upper limit value of a dose of the infusion solution that can be administered in the same period when bubbles of the first bubble volume are detected when the infusion solution is delivered during the first period. 4. The infusion pump of claim 3, which increments the preset dose of the infusion for the second time period by no more than .
When a first amount of air bubbles is detected when the infusion solution is delivered in the first period, the control unit performs the plurality of second periods in a plurality of second periods subsequent to the first period. wherein the dose of the infusion solution preset for each of the periods is corrected by incrementing the additional dose obtained by dividing the first bubble volume by the number of the plurality of second periods. An infusion pump as described in .
The infusion pump according to any one of claims 1 to 5, wherein the controller detects the amount of air bubbles contained in the infusion based on the light intensity in the region occupied by the infusion tube in the captured image.
7. Any one of claims 1 to 6, wherein the controller detects the amount of bubbles contained in the infusion solution based on a boundary between the infusion solution and the air bubbles in a region occupied by the infusion tube in the captured image. 10. An infusion pump according to any one of the preceding paragraphs.
A control method for an infusion pump equipped with a controller for delivering a preset dose of infusion through an infusion tube, comprising:
The control unit
obtaining a photographed image of the infusion tube photographed by a two-dimensional sensor;
analyzing the photographed image to detect the amount of air bubbles contained in the infusion solution;
correcting the dosage based on the amount of the detected air bubbles;
A method of controlling an infusion pump, comprising: