WO2023047608A1 - Dispositif de bnct robotisé et son procédé de fonctionnement - Google Patents

Dispositif de bnct robotisé et son procédé de fonctionnement Download PDF

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Publication number
WO2023047608A1
WO2023047608A1 PCT/JP2021/044945 JP2021044945W WO2023047608A1 WO 2023047608 A1 WO2023047608 A1 WO 2023047608A1 JP 2021044945 W JP2021044945 W JP 2021044945W WO 2023047608 A1 WO2023047608 A1 WO 2023047608A1
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neutron beam
beam irradiation
neutron
tumor site
bnct
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PCT/JP2021/044945
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English (en)
Japanese (ja)
Inventor
雄二 古久保
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雄二 古久保
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Priority to CN202180091171.8A priority Critical patent/CN116847906A/zh
Publication of WO2023047608A1 publication Critical patent/WO2023047608A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the present invention relates to a robot BNCT (Boron-Neutron Capture Therapy) device and its operating method. More specifically, an industrial robot moves a neutron beam irradiation device to irradiate a patient's tumor site with a neutron beam. and a method of operating a robotic BNCT device for treating cancer.
  • BNCT Bi-Neutron Capture Therapy
  • BNCT boron neutron capture therapy
  • boron nuclides have a large neutron capture cross-section, and when irradiated with a thermal neutron beam (n), they efficiently cause a nuclear reaction such as the following (1) and emit high-energy 7 Li and 4 He particle radiation. do. 10B +n ⁇ 7Li + 4He (1)
  • the 7 Li and 4 He particle radiation has a short range, it disappears within the cancer cells that have undergone a nuclear reaction and does not affect the outside of the cancer cells. It is characterized by being able to selectively destroy only cancer cells that have taken up.
  • the BNCT device has a velocity distribution (energy spectrum) suitable for decelerating the high-speed (high-energy) neutron beam emitted by the neutron beam generator between the neutron beam irradiation device and the patient and using it for BNCT.
  • a neutron moderator is provided which converts to neutron beams.
  • BNCT equipment can irradiate refractory tumor sites, such as those in which normal cells and cancer cells coexist, with neutron beams. It is an excellent radiation cancer treatment device that can selectively destroy only cancer cells.
  • neutron beams in order to completely destroy cancer cells, it is necessary to irradiate neutron beams with a predetermined dose or more, but neutron beams also damage normal cells, albeit weakly.
  • a treatment protocol is adopted in which a large amount of neutron beam is irradiated once so that the absorbed dose at the tumor site is as high as 40 to 60 Gy.
  • damage to normal cells by neutron beams is also increased, and there is a problem that the incidence of side effects due to radiation damage increases.
  • a BNCT apparatus has been developed that reduces the dose of neutron beams to normal regions other than the tumor region by irradiating the tumor region with neutron beams from multiple directions.
  • a BNCT apparatus has been studied in which a plurality of (for example, six) neutron beam generators are arranged on the same plane around a patient and neutron beams are irradiated to the tumor site from multiple directions (for example, Patent Document 1 , and FIG. 5).
  • the neutron beams emitted from the three neutron beam irradiation devices (irradiation devices 4 to 6) near the tumor site among the six neutron beam irradiation devices efficiently reach the tumor site.
  • the neutron beams emitted from the remaining three units (irradiators 1 to 3) are far from the tumor site, and there is a problem that the neutron beams do not efficiently reach the tumor site.
  • the neutron beam irradiation device described in Patent Document 1 requires as many as six neutron beam irradiation devices with a large irradiation dose in order to set the neutron beam irradiation time to an appropriate treatment time of about 20 to 30 minutes. need to use.
  • the BNCT apparatus is also a form of radiotherapy apparatus, and it goes without saying that the occurrence of side effects can be suppressed by irradiating a small amount of neutron beams in multiple doses rather than by irradiating a large amount of neutron beams at once.
  • the conventional neutron beam irradiation apparatus slows down the high-speed (high-energy) neutron beam emitted by the neutron beam generator and converts it into a neutron beam having a velocity distribution (energy spectrum) suitable for treatment.
  • the structure of the body is fixed. Therefore, the neutron moderator must be replaced according to the patient's body shape and tumor site (distance from the skin surface to the tumor site). There is also the problem that it takes time and effort to prepare for irradiation treatment and clean up afterwards.
  • a neutron beam irradiation device is movably installed, and a single neutron beam irradiation device is used to emit neutron beams from a plurality of neutron beam irradiation positions to a patient's tumor site. It is an object of the present invention to provide a BNCT apparatus capable of irradiation. In addition, the BNCT apparatus of the present invention prevents leakage of neutron beams to the outside of the neutron beam irradiation apparatus, and generates neutrons having an energy amount suitable for BNCT at a position close to the body surface of the patient's tumor site. It is an object of the present invention to provide a BNCT device that prevents neutrons from leaking in directions other than the tumor site.
  • the BNCT apparatus of the present invention generates a neutron beam having an energy amount suitable for BNCT at a position close to the body surface of the patient's tumor site, performs neutron beam irradiation from a distance close to the tumor site, and further neutron beams.
  • a neutron beam irradiation apparatus capable of performing efficient therapeutic irradiation of neutrons using a neutron beam irradiation apparatus with a lower neutron generation intensity than before by automating the movement of the irradiation apparatus and irradiating without waste. do.
  • a plurality of types of neutron moderators are prepared in advance in order to decelerate the high-speed neutron beam from the neutron generator to a neutron beam with a speed suitable for treatment, and the industrial robot automatically By selecting an appropriate neutron moderator and attaching it to the neutron beam irradiation equipment, high-speed neutron beams are slowed down to neutron beams with a speed suitable for BNCT treatment. It is an object of the present invention to provide an effective BNCT device.
  • the BNCT apparatus of the present invention includes a neutron beam irradiation device having an accelerator neutron source and a neutron moderator, and a control device.
  • a BNCT apparatus for irradiating a patient with a tumor site with neutrons comprising: an industrial robot that moves and controls the apparatus, the BNCT apparatus comprising: A boron-containing compound that is absorbed or accumulated in a large amount in cancer cells is administered, and within a time period when the intracellular concentration of the boron-containing compound in the patient is higher than the normal intracellular concentration, the industrial robot irradiates the neutron beam irradiation device to the patient. is sequentially moved to a plurality of neutron beam irradiation positions corresponding to the tumor site of the patient, and the tumor site of the patient is irradiated with the neutron beam.
  • the neutron beam irradiation device is equipped with a neutron reflector so as to surround the shroud of the accelerator neutron source, and can prevent neutron beams from leaking from the neutron beam irradiation device in directions other than the patient direction.
  • the neutron beam irradiation device has a neutron moderator attached to the tip of the accelerator neutron source, and generates neutrons having an energy amount suitable for BNCT therapy at a position close to the body surface of the tumor site, It is characterized by irradiating to Moreover, it is preferable that the industrial robot moves the neutron beam irradiation device to a neutron beam irradiation position close to the body surface of the tumor site and irradiates the tumor site with the neutron beam.
  • the neutron beam irradiation device presets a plurality of neutron beam irradiation positions for irradiating a tumor site with neutron beams, a neutron beam irradiation time at each neutron beam irradiation position, and a neutron moderator to be mounted at the neutron beam irradiation position.
  • the industrial robot moves the neutron beam irradiation device according to a plurality of preset neutron beam irradiation positions and a preset neutron beam irradiation time, and neutron beams are delivered to the tumor site via a preset neutron moderator. It is characterized by irradiating
  • the neutron beam irradiation device preliminarily sets a neutron beam irradiation route for connecting the plurality of neutron beam irradiation positions and irradiating a tumor site with a neutron beam, a moving speed in each section of the neutron beam irradiation route, and a neutron moderator to be mounted. set, the industrial robot moves the neutron beam irradiation device according to the preset neutron beam irradiation route and the movement speed in each section of the neutron beam irradiation route, and neutrons are delivered to the tumor site via the preset neutron moderator It is characterized by irradiating rays.
  • the plurality of neutron beam irradiation positions or neutron beam irradiation paths are arranged in a three-dimensional positional relationship, and the industrial robot can determine the position of the neutron beam irradiation device or the neutron beam irradiation device at each of the plurality of neutron beam irradiation positions or neutron beam irradiation paths. It is preferable to control the irradiation path, installation angle, neutron beam irradiation angle, movement route, movement speed, etc. based on the three-dimensional positional relationship with the tumor site.
  • the neutron beam irradiation device has a titanium target that generates neutrons
  • the industrial robot has a plurality of neutron beam irradiation positions or positions of the titanium target in each of the neutron beam irradiation paths, the neutron beam irradiation path, the neutron emission surface is controlled based on the three-dimensional positional relationship with the tumor site.
  • the industrial robot is characterized by controlling the neutron emitting surface of the titanium target so that it always faces the tumor site while the titanium target moves along a predetermined neutron beam irradiation path.
  • the present invention includes installing a plurality of neutron beam irradiation devices and the same number of industrial robots as the neutron beam irradiation devices, and allowing the plurality of industrial robots to simultaneously irradiate neutron beams from the plurality of neutron beam irradiation devices. Characterized by
  • a method for operating a BNCT apparatus of the present invention is a method using the robotic BNCT apparatus according to any one of claims 1 to 10, wherein the patient having the tumor site is irradiated with neutron beams. administering a boron-containing compound that is absorbed or accumulated in cancer cells to a greater extent than in normal cells, and within a time period in which the intracellular concentration of the boron-containing compound in the patient is higher than the normal intracellular concentration,
  • the industrial robot is characterized by sequentially moving a neutron beam irradiation device to a plurality of neutron beam irradiation positions corresponding to the patient's tumor site and causing the patient's tumor site to be irradiated with neutron beams.
  • the control device preferably causes the industrial robot to move the neutron beam irradiation device to a neutron beam irradiation position close to the body surface of the patient's tumor site and irradiate the tumor site with neutron beams.
  • control device presets a plurality of neutron beam irradiation positions for irradiating a tumor site with neutron beams, a neutron beam irradiation time at each neutron beam irradiation position, and a neutron moderator to be mounted, and irradiates the industrial robot with neutron beams.
  • the apparatus is moved according to a plurality of preset neutron beam irradiation positions and neutron beam irradiation times, and the tumor site is irradiated with neutron beams via a preset neutron moderator.
  • control device provides, in the neutron beam irradiation device, a plurality of neutron beam irradiation routes for connecting a plurality of neutron beam irradiation positions and irradiating a tumor site with a neutron beam, a moving speed in each section of the neutron beam irradiation route, and a mounting
  • a neutron moderator is preset, an industrial robot moves a neutron beam irradiation device according to the preset neutron beam irradiation route and the movement speed in each section of the preset neutron beam irradiation route, and the preset neutron It is preferable to irradiate the tumor site with neutron beams via a moderator.
  • the plurality of neutron beam irradiation positions or neutron beam irradiation paths are arranged in a three-dimensional positional relationship, and the control device instructs the industrial robot to neutron beam irradiation at each of the plurality of neutron beam irradiation positions or neutron beam irradiation paths.
  • the positions of the plurality of neutron beam irradiation devices in each of the positions of the devices or the neutron beam irradiation routes, the neutron beam irradiation routes, installation angles, neutron irradiation angles, movement routes, and movement speeds are three-dimensionally compared with the tumor site. It is characterized in that it is controlled based on the positional relationship.
  • the neutron beam irradiation device has a titanium target that generates neutrons
  • the control device provides the industrial robot with a plurality of neutron beam irradiation positions or the position of the titanium target in each of the neutron beam irradiation paths, the angle of the neutron emission surface, , movement route, movement speed, etc. are preferably controlled based on the three-dimensional positional relationship with the tumor site.
  • control device can cause the industrial robot to control the neutron emitting surface of the titanium target to always face the tumor site while the titanium target is moving along a predetermined movement path.
  • control device causes the industrial robot to move the neutron beam irradiation device to the treatment starting point, then direct the titanium target to the tumor site and start neutron beam irradiation, and neutron irradiation without stopping the neutron beam irradiation device.
  • the irradiation is terminated by moving the irradiation path to the neutron beam irradiation end position.
  • the control device instructs the plurality of industrial robots to simultaneously emit neutron beams from the plurality of neutron beam irradiation devices. It is characterized by performing irradiation.
  • the BNCT apparatus of the present invention uses an industrial robot to move the neutron beam irradiation device according to the position of the patient's tumor site and the patient's body shape, and from the neutron beam irradiation position at a distance close to the tumor site in an efficient irradiation direction. Since neutron beam irradiation is performed, even a neutron beam irradiation apparatus having a neutron intensity of about half that of the conventional method has a feature that the therapeutic effect can be improved within an appropriate treatment time.
  • the BNCT device of the present invention compacts the neutron beam irradiation device to a size that can be transported by an industrial robot. It is characterized in that the irradiation device can be moved using an industrial robot and that the installation cost can be significantly reduced.
  • the BNCT apparatus of the present invention efficiently sets the neutron beam irradiation position and neutron irradiation path of the neutron beam irradiation device based on the three-dimensional positional relationship with the tumor site, and the industrial robot automatically sets the neutron beam irradiation device. is moved, and the titanium target is constantly directed at the tumor site to irradiate the neutron beam, so it is possible to increase the irradiation effect on cancer cells and reduce the irradiation dose received by normal cells, thereby reducing side effects.
  • a neutron reflector is attached so as to surround the shroud of the neutron generator, and a neutron moderator is attached to the tip of the neutron generator. can be generated and the absorbed dose of the adjacent body surface portion can be minimized.
  • a neutron moderator is attached to the tip of the neutron generator.
  • the industrial robot can replace the neutron moderators according to the patient's body shape and the position of the tumor, it is possible to obtain an appropriate neutron moderator according to the patient's body shape and tumor site.
  • Neutron beam irradiation can be performed, and furthermore, there is no need to manually replace the neutron moderator every time the patient changes, which can reduce treatment time and costs.
  • the BNCT apparatus of the present invention is characterized in that the patient only needs to lie in a supine position on a fixed treatment table during treatment, and it is possible to provide a treatment with less physical and mental burden.
  • FIG. 1 is an overall view of a robotic BNCT device according to one embodiment of the present invention
  • FIG. 1 is a schematic diagram showing a neutron beam irradiation device according to an embodiment of the present invention
  • FIG. It is a figure explaining the neutron beam irradiation method based on 1 Example of this invention. It is a figure explaining the neutron beam irradiation method based on other Example of this invention.
  • It is a schematic diagram of a BNCT apparatus provided with six conventional neutron beam irradiation apparatuses. 6 is a diagram showing the relationship between the neutron beam irradiation device in FIG. 5 and a tumor site;
  • FIG. 1 is an overall view of a robotic BNCT device according to one embodiment of the present invention
  • FIG. 1 is a schematic diagram showing a neutron beam irradiation device according to an embodiment of the present invention
  • FIG. It is a figure explaining the neutron beam irradiation method based on 1 Example of this invention. It is
  • the boron nuclide captures neutrons upon irradiation with a neutron beam (n) to cause a nuclear reaction, generating high-energy 7 Li and 4 He particle radiation. 10B +n ⁇ 7Li + 4He (1)
  • BNCT administers a boron-containing compound that has the property of accumulating in cancer cells to the cancer patient, and accumulates boron in the patient's cancer cells
  • the boron atoms accumulated in the cancer cells capture the neutrons and cause a nuclear reaction. It is a cancer therapy that selectively destroys and cures cancer.
  • 7 Li and 4 He particle beams have a short lifespan, and their ranges are about the same as the size of cancer cells. can selectively destroy only cancer cells bound to
  • the patient prior to the therapeutic irradiation of neutron beams, the patient is administered a boron-containing compound that, when administered to a living body, is absorbed or accumulated in cancer cells to a greater extent than in normal cells, Boron compounds accumulate in cancer cells.
  • boron-containing compounds are known, the examples of the present invention show examples using p-boronophenylalanine as the boron-containing compound.
  • FIG. 1 is an overall schematic diagram of a robotic BNCT device 1 according to one embodiment of the present invention.
  • the robot BNCT device 1 of the present invention has an accelerator neutron source 18 that generates neutrons and a neutron moderator 24 that decelerates the neutrons, and irradiates a tumor site 5 of a patient 3 with neutron beams.
  • a neutron beam irradiation device 20 and an industrial robot 10 having a control device (not shown) to control and move the neutron beam irradiation device 20 are provided.
  • the patient 3 only needs to fix the irradiation site, and for example, the patient 3 can be treated by the robot BNCT apparatus 1 while lying on the operating table 12 .
  • the industrial robot 10 having the functions used in the present invention can be purchased by placing an order with a specialized manufacturer.
  • FIG. 2 is a schematic diagram showing a neutron beam irradiation apparatus according to one embodiment of the present invention.
  • a neutron beam irradiation apparatus 20 according to an embodiment of the present invention includes a deuterium ion source 16 that generates deuterium cations, and an accelerator neutron source that is decompressed to a high vacuum by a vacuum pump 14. 18 and .
  • the deuterium ion source 16 can be of any known type, and is not particularly limited as long as it can be used in the present invention.
  • a deuterium cation generator can be used.
  • the deuterium cations generated by the deuterium ion source 16 enter the acceleration chamber 19 from the ion extraction iris 28 and enter the magnetic field ( (not shown), collide at high speed with a target provided at the tip of the neutron beam irradiation device 20, and generate neutrons (n) by the DD reaction of the following formula (3).
  • a titanium target 22 can be used as the target. D+D ⁇ 3 He+n (3)
  • the neutrons generated by the DD reaction are too fast (too high in energy) and may destroy normal cells, which is not preferable for BNCT.
  • a neutron moderator 24 is preferably provided on the opposite side to moderate fast neutrons to neutrons (epithermal neutrons, thermal neutrons) having an energy content suitable for BNCT.
  • the industrial robot 10 always directs the neutron radiation surface 23 of the neutron beam irradiation device 20 or the titanium target 22 toward the tumor site 5 and irradiates the neutron beam, so that cancer of the tumor site 5
  • the effect of irradiation on cells can be increased while the dose of irradiation received by normal cells can be reduced.
  • the accelerator neutron beam generator 18 is preferably equipped with a neutron reflector 29 so as to surround the shroud 26 to prevent neutron beams from leaking in directions other than the patient. As a result, useless neutrons can be reduced and the therapeutic effect can be enhanced.
  • the neutron beam irradiation apparatus 20 of the present invention it is preferable to provide the neutron moderator 24 at a position close to the body surface 7 of the patient 3 at the tip of the neutron beam irradiation apparatus 20 .
  • the neutron beam irradiation device 20 can irradiate the tumor site 5 with neutron beams from a position close to the body surface 7 corresponding to the tumor site 5, so the neutron beam irradiation device 20 with low irradiation intensity can be used.
  • a plurality of types of neutron moderators 24 are prepared in advance in order to decelerate high-speed neutron beams from the neutron generator to neutron beams with a speed suitable for treatment, and the industrial robot 10 automatically reduces neutron beams. It is preferable to provide a mechanism for selecting the moderator 22 and mounting it on the neutron beam irradiation apparatus. As a result, the neutron moderator 22 can be selected according to the type of tumor, the position of the tumor site, the body type of the patient, etc., and the neutron beam can be moderated to a speed appropriate for treatment.
  • a plurality of industrial robots 10 can be installed and neutron beam irradiation can be performed simultaneously from a plurality of neutron beam irradiation devices 20 .
  • the robot BNCT of the present invention administers a boron-containing compound that, when administered to the patient, is absorbed or accumulated in cancer cells in greater amounts than in normal cells of patient 3, and is administered.
  • the industrial robot 10 controls the neutron beam irradiation device 20 to irradiate the tumor site 5 of the patient 3 with neutron beams within the time when the intracellular concentration of the boron-containing compound is higher than the normal intracellular concentration.
  • FIG. 3 is a diagram for explaining a neutron beam irradiation method according to an embodiment of the present invention.
  • a controller (not shown) controls a plurality of neutron beam irradiation apparatuses 20 for irradiating a tumor site 5 with neutron beams.
  • the neutron beam irradiation position 34, the neutron beam irradiation time at each neutron beam irradiation position 34, and the neutron moderator 24 to be attached to the titanium target 22 at each neutron beam irradiation position 34a to 34n are set in advance, and the industrial robot 10 is provided with a neutron beam.
  • the irradiation device 20 is controlled to move to preset neutron beam irradiation positions 34a to 34n, and the tumor site 5 is irradiated with neutron beams via the neutron moderator 24 selected in advance.
  • the neutron beam irradiation method using the robot BNCT device 1 of the present invention it is possible to arrange a plurality of neutron beam irradiation positions 34a to 34n in a three-dimensional positional relationship, and the industrial robot 10 is set in advance.
  • the position, installation angle, neutron irradiation angle, movement route, movement speed, etc. of the neutron beam irradiation device at each of the plurality of neutron beam irradiation positions 34a to 34n can be controlled based on the three-dimensional positional relationship with the tumor site 5. preferable.
  • FIG. 4 is a diagram for explaining a neutron beam irradiation method according to another embodiment of the present invention.
  • the neutron beam irradiation method using the robot BNCT device 1 includes a plurality of neutron irradiation sections 36a to 36a in which the neutron beam irradiation device 20 irradiates the tumor site 5 with neutron beams.
  • the neutron beam irradiation path 36 consisting of 36n, the movement speed in each neutron irradiation section 36a to 36n, and the neutron moderator 24 attached to the titanium target 22 in each neutron irradiation section 36a to 36n are set in advance, and the industrial robot 10 sets the neutron beam.
  • a neutron moderator 24 having a thickness selected in advance is mounted to irradiate the tumor site 5 with neutron beams.
  • the dose of neutron beams to the tumor site 7 can be controlled by the moving speed of the neutron beam irradiation device 20 .
  • the treatment method using the robot BNCT device 1 it is possible to arrange a plurality of neutron beam irradiation paths 36 in a three-dimensional positional relationship.
  • the position, installation angle, neutron irradiation angle, movement route, movement speed, etc. of the neutron beam irradiation device in each of the set multiple neutron beam irradiation sections 36a to 36n are controlled based on the three-dimensional positional relationship with the tumor site 5. can do.
  • the neutron beam irradiation device 20 is moved to the neutron irradiation start position 38, and the titanium target 22 in the neutron beam irradiation device 20 is moved to the immediate vicinity of the neutron beam irradiation start position 36a. is moved to a position close to the body surface 7 corresponding to the tumor site 5, the neutron beam irradiation surface 23 of the titanium target 22 is directed toward the tumor site 5, neutron beam irradiation is started, and the neutron beam irradiation device 20 is stopped. It is possible to complete the irradiation by moving to the neutron beam irradiation end position 39 without any need.
  • the position of the titanium target 22, the angle of the neutron emission surface, the movement route, and the movement speed are controlled based on the three-dimensional positional relationship with the tumor site 5. can be done.

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  • Biomedical Technology (AREA)
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Abstract

L'invention concerne un dispositif de thérapie à capture de neutrons par le bore (BNCT) qui déplace une position de rayonnement de faisceau de neutrons d'un dispositif de rayonnement de faisceau de neutrons et peut rayonner un faisceau de neutrons à partir de nombreuses positions de rayonnement de faisceau de neutrons efficaces sur le site tumoral d'un patient.　Ce dispositif de BNCT émet un faisceau de neutrons en direction d'un patient présentant un site tumoral et comprend : un dispositif de rayonnement de faisceau de neutrons ayant une source de génération de neutrons à accélérateur et un modérateur de neutrons ; et un robot industriel qui déplace le dispositif de rayonnement de faisceau de neutrons. Avant que le patient ne soit irradié par le faisceau de neutrons, un composé contenant du bore est administré au patient et, pendant le temps durant lequel la concentration du composé contenant du bore est plus élevée dans les cellules cancéreuses que dans les cellules normales du patient, le robot industriel déplace le dispositif de rayonnement de faisceau de neutrons et le site tumoral du patient est irradié par le faisceau de neutrons.
PCT/JP2021/044945 2021-09-22 2021-12-07 Dispositif de bnct robotisé et son procédé de fonctionnement WO2023047608A1 (fr)

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CN202180091171.8A CN116847906A (zh) 2021-09-22 2021-12-07 机器人bnct装置及其操作方法

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JP2021154885A JP2023046143A (ja) 2021-09-22 2021-09-22 ロボットｂｎｃｔ装置及びその作動方法
JP2021-154885 2021-09-22

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008100269A2 (fr) * 2006-06-09 2008-08-21 The Regents Of The University Of California Source de neutrons compacte et modérateur
US20130066135A1 (en) * 2011-08-29 2013-03-14 Louis Rosa Neutron irradiation therapy device
WO2017211331A1 (fr) * 2016-06-10 2017-12-14 Fyzikalni Ustav Av Cr, V.V.I. Dispositif et procédé pour une radiothérapie par impulsions à dose élevée avec une imagerie en temps réel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008100269A2 (fr) * 2006-06-09 2008-08-21 The Regents Of The University Of California Source de neutrons compacte et modérateur
US20130066135A1 (en) * 2011-08-29 2013-03-14 Louis Rosa Neutron irradiation therapy device
WO2017211331A1 (fr) * 2016-06-10 2017-12-14 Fyzikalni Ustav Av Cr, V.V.I. Dispositif et procédé pour une radiothérapie par impulsions à dose élevée avec une imagerie en temps réel

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