WO2023039453A3 - Dual-function polypeptides and methods for use thereof - Google Patents

Dual-function polypeptides and methods for use thereof Download PDF

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Publication number
WO2023039453A3
WO2023039453A3 PCT/US2022/076083 US2022076083W WO2023039453A3 WO 2023039453 A3 WO2023039453 A3 WO 2023039453A3 US 2022076083 W US2022076083 W US 2022076083W WO 2023039453 A3 WO2023039453 A3 WO 2023039453A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
dual
chimeric polypeptides
function
polypeptides
Prior art date
Application number
PCT/US2022/076083
Other languages
French (fr)
Other versions
WO2023039453A2 (en
Inventor
Xiao MA
John C. Burnett, Jr.
Original Assignee
Mayo Foundation For Medical Education And Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation For Medical Education And Research filed Critical Mayo Foundation For Medical Education And Research
Publication of WO2023039453A2 publication Critical patent/WO2023039453A2/en
Publication of WO2023039453A3 publication Critical patent/WO2023039453A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Chimeric polypeptides that exhibit pGC-A gain of function and inhibit PKC are provided herein. For example, this document provides chimeric polypeptides containing an alternatively spliced form of atrial natriuretic peptide (MANP) and a PKC inhibitor. Methods for using the chimeric polypeptides to treat cardiovascular disease also are provided.
PCT/US2022/076083 2021-09-09 2022-09-08 Dual-function polypeptides and methods for use thereof WO2023039453A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163242329P 2021-09-09 2021-09-09
US63/242,329 2021-09-09

Publications (2)

Publication Number Publication Date
WO2023039453A2 WO2023039453A2 (en) 2023-03-16
WO2023039453A3 true WO2023039453A3 (en) 2023-04-20

Family

ID=85506928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2022/076083 WO2023039453A2 (en) 2021-09-09 2022-09-08 Dual-function polypeptides and methods for use thereof

Country Status (1)

Country Link
WO (1) WO2023039453A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090069243A1 (en) * 2005-09-16 2009-03-12 Mayo Foundation For Medical Education And Research Natriuretic activities
US20140066367A1 (en) * 2012-08-31 2014-03-06 Mayo Foundation For Medical Education And Research Subcutaneous delivery of a long-acting natriuretic peptide
WO2020097421A1 (en) * 2018-11-09 2020-05-14 Mayo Foundation For Medical Education And Research Combination treatment for resistant hypertension

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090069243A1 (en) * 2005-09-16 2009-03-12 Mayo Foundation For Medical Education And Research Natriuretic activities
US20140066367A1 (en) * 2012-08-31 2014-03-06 Mayo Foundation For Medical Education And Research Subcutaneous delivery of a long-acting natriuretic peptide
WO2020097421A1 (en) * 2018-11-09 2020-05-14 Mayo Foundation For Medical Education And Research Combination treatment for resistant hypertension

Also Published As

Publication number Publication date
WO2023039453A2 (en) 2023-03-16

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