WO2023033593A1

WO2023033593A1 - Chiral structure having optical activity from ultraviolet to short-wave infrared region, and preparation method therefor

Info

Publication number: WO2023033593A1
Application number: PCT/KR2022/013206
Authority: WO
Inventors: 염지현; 박기현; 권준영
Original assignee: 한국과학기술원
Priority date: 2021-09-03
Filing date: 2022-09-02
Publication date: 2023-03-09

Abstract

The present invention relates to a chiral structure and, specifically, to a chiral structure and a preparation method therefor, the chiral structure having chirality from atomic level to micro level that is transferred using nanoparticle self-assembly in order to be applied to more various fields, and thus has optical activity in a wide range from ultraviolet to short-wave infrared region.

Description

Chiral structure having optical activity in the ultraviolet range to short infrared range and method for preparing the same

The present invention relates to a chiral structure having optical activity in an ultraviolet range to a short infrared range and a method for preparing the same.

Chiral materials have optical activity derived from the difference in the degree of absorption according to left-circularly polarized light (LCP) and right-circularly polarized light (RCP), and these properties are used in 3D display, It is applied as a promising platform in chiral sensors, spintronics, and nanomedicine.

This optical activity is derived from the structural chirality of the material, which exists on all scales from the atomic level to the macro-level. Typically, in the case of organic molecules, light in the ultraviolet region is absorbed due to the presence of a chiral center at the atomic level, and thus, optical properties in the ultraviolet region (UV, 200 nm to 400 nm) show activity. In the case of nanoparticles, they show structural chirality caused by distortion of their crystal structure, and thus have optical activity in the ultraviolet-visible ray region (UV-Vis, 200 nm to 700 nm).

In addition, research on synthesizing chiral materials having optical activity in the near-infrared (Near-Infrared, 700 nm to 1700 nm) region beyond the ultraviolet-visible region is being actively conducted. Materials tend to interact more actively with light of a similar scale depending on their size, so the key is to synthesize a material with a micro size in order to give it a property of absorbing light in the near-infrared region.

Since light in the short infrared region (SWIR, 1700 nm to 2500 nm) has a property of penetrating the skin well, studies showing various properties when interacting with biomolecules have been reported. As an example, diagnostic techniques and heat treatment techniques have been proposed using the fact that the neural system is stimulated and activated when short-infrared light is absorbed. In addition, in the case of cancer cells (tumor) or bone tissue (bone tissue), as the property of absorbing short-infrared light is reported, imaging techniques are also being developed.

Therefore, if a material that exhibits optical activity beyond the near-infrared region to the short-infrared region is synthesized, various applications to bio systems will be possible. In order to synthesize such a material, a synthesis technology that has a size similar to the wavelength of light in the short-infrared region and has structural chirality must be developed.

Techniques that have been attempted to solve this problem so far include 1) a top-down etching method using lithography technology and 2) a method using a material having chirality as a template, but optics in the short infrared region A substance having an activity has not yet been developed. In addition, the first method requires state-of-the-art equipment, and has the disadvantage of high price and time. Therefore, there is a limit to synthesizing a bidirectional chiral enantiomer.

Therefore, there is a need to develop a material having optical activity in a wide range from the ultraviolet to the short infrared, which can solve the above-mentioned disadvantages.

One object of the present invention is to provide a chiral structure having optical activity in a wide range from the ultraviolet to the short infrared, and a precursor composition for preparing the chiral structure.

Another object of the present invention is to provide a method for preparing a chiral structure having optical activity in a wide range from the ultraviolet to the short infrared.

Another object of the present invention is to provide a biosensor and an optical device including the chiral structure described above.

One embodiment of the present invention, in order to solve the above-described problems, includes chiral nanoparticles, ultraviolet-visible (UV-Vis), near-infrared (NIR) and short-infrared (SWIR) optics in the region An active, chiral structure is provided.

In one embodiment, the chiral structure may be a superparticle assembly prepared by self-assembly of the chiral nanoparticles.

In one embodiment, the chiral structure may have a structure in which two or more ellipsoids are stacked while rotating in a clockwise or counterclockwise direction.

In one embodiment, the major diameter of the ellipsoid may be 1 μm to 10 μm.

In one embodiment, the chiral structure may have a maximum peak wavelength in the range of 800 nm to 1500 nm when the circular polarization = dichroism spectrum is measured.

In one embodiment, the chiral nanoparticle may be a metal compound.

In one embodiment, the metal may be any one selected from Group 11 transition metals.

In one embodiment, the chiral nanoparticle may be prepared from a chiral ligand.

In one embodiment, the chiral ligand may be an L-amino acid or a D-amino acid.

In one embodiment, the chiral nanoparticles may have an average diameter of 1 nm to 10 nm.

Another embodiment provides a precursor composition for preparing a chiral structure, including a chiral ligand, a metal precursor, and a chalcogen precursor.

In one embodiment, the chiral ligand may be an L-amino acid or a D-amino acid.

In one embodiment, the chiral ligand may be L-cysteine or D-cysteine.

Another embodiment includes a first step of preparing chiral nanoparticles by reacting a precursor composition for preparing a chiral structure including a chiral ligand and a metal precursor; and a second step of preparing a micro-sized chiral structure by dispersing the chiral nanoparticles in a medium; It provides a method for producing a chiral structure comprising a.

In one embodiment, the precursor composition for preparing the chiral structure may further include a chalcogen precursor.

In one embodiment, the molar ratio of chiral ligand:metal precursor:chalcogen precursor may be 1:0.1 to 0.8:0.1 to 0.6.

In one embodiment, the second step may be to prepare a micro-sized chiral structure by self-assembling the chiral nanoparticles.

Another embodiment provides a biosensor or optical device including the chiral structure described above.

The chiral structure according to the present invention has optical activity in a wide range from 200 nm to 2500 nm, which is a short infrared region in the ultraviolet region, so that it can be used in more diverse fields such as biosensors, optical devices, metamaterial development, communication, and asymmetric catalysts. can be applied

In addition, the chiral structure according to the present invention has the advantage that it can be more easily prepared using the self-assembly phenomenon of chiral nanoparticles.

1 is a schematic diagram showing a process of synthesizing and self-assembling chiral copper sulfide nanoparticles using cysteine.

2 is an SEM image of the structures of Example 1, Example 2 and Comparative Example 1.

3 is a graph of the anisotropic g factor of structures of Examples 1, 2, and Comparative Example 1;

4 is a circular dichroism (CD) graph of the structures of Example 1, Example 2 and Comparative Example 1.

5 is a TEM image obtained by observing the process of self-assembly of chiral nanoparticles according to aging time.

6 is a CD graph showing changes in chirality according to aging time.

7 is an absorbance graph showing changes in chirality according to aging time.

8 is a CD graph of cysteine molecules, chiral nanoparticles, and chiral structures of Examples 1 and 2;

9, 10 and 11 are SEM images, g factor graphs, and CD graphs of chiral structures prepared according to the organic ligand and cysteine usage ratio, respectively.

The embodiments described in this specification may be modified in many different forms, and a technology according to an embodiment is not limited to the embodiment described below. In addition, embodiments of one embodiment are provided to more completely explain the present disclosure to those skilled in the art.

Also, the singular forms used in the specification and appended claims may be intended to include the plural forms as well, unless the context dictates otherwise.

Further, as used herein, numerical ranges include lower and upper limits and all values within that range, increments logically derived from the shape and breadth of the defined range, all values defined therebetween, and the upper limit of the numerical range defined in a different form. and all possible combinations of lower bounds. Unless otherwise specifically defined in the specification of the present invention, values outside the numerical range that may occur due to experimental errors or rounding of values are also included in the defined numerical range.

Furthermore, "include" a certain component throughout the specification means that other components may be further included without excluding other components unless otherwise stated.

In this specification, the major axis refers to the length of the longest major axis of the particle, and the minor axis refers to the longest length in a direction perpendicular to the major axis (hereinafter referred to as 'minor axis direction').

Materials tend to interact more actively with light of a similar scale depending on their size. In particular, light in the short-infrared region interacts actively with biomolecules, making it applicable not only to optical devices and communications, but also to the biofield. For this, it is essential to develop a chiral material having optical activity from the ultraviolet to the short infrared. However, the conventional chiral material synthesis technology cannot synthesize a material having optical activity in the short-infrared region, and has limited optical activity only in the ultraviolet and visible light regions, and thus has limitations in application in various fields including bio and communication. .

Accordingly, the inventors of the present invention repeatedly studied synthesis techniques for substances having optical activity in a wide range up to the single infrared region in order to utilize chiral substances in more diverse fields, and as a result, by using materials having self-assembly characteristics, The present invention was completed by discovering that a chiral structure having optical activity in a wide range from to the single infrared range could be more easily synthesized.

A chiral structure according to an embodiment includes chiral nanoparticles, and is characterized in that it has optical activity in the ultraviolet-visible (UV-Vis) region, the near-infrared (NIR) region, and the short-infrared (SWIR) region.

The chiral structure has chirality, which is an asymmetric property, by including chiral nanoparticles, and specifically has optical activity in a wide range from the ultraviolet region to the short infrared region, thereby enabling biosensors, optical devices, metamaterials, communication and asymmetric It can be usefully applied to various fields such as catalysts. In this case, the ultraviolet-visible ray region means a wavelength range of 200 nm to 700 nm, the near infrared region 700 nm to 1700 nm, and the short infrared region 1700 nm to 2500 nm.

The chiral structure may be an assembly of supraparticles prepared by self-assembly of the chiral nanoparticles. The superparticles refer to particles aggregated with a certain regularity by interactions between chiral nanoparticles, and aggregation continues to occur due to interactions between these superparticles, resulting in chiral properties even at the micro level of 10 ⁰ to 10 ² μm. A chiral structure having can be formed. By using such chiral nanoparticles having self-assembly characteristics, a chiral structure having optical activity in a wide range from an ultraviolet region to a short infrared region can be more easily prepared.

In one embodiment, the chiral structure may have a structure in which two or more ellipsoids are stacked while rotating in a clockwise or counterclockwise direction. By having the above structure, the chiral structure according to one embodiment can have optical activity in a wide range from the ultraviolet region to the short infrared region by transferring atomic level chirality to the micro level.

The ellipsoid may have a major diameter of 1 μm to 10 μm, specifically 1 μm to 5 μm, and more specifically 1 μm to 3 μm, and by having a size in the above range, near-infrared rays and short rays similar to the size of the above range It may interact with light in the infrared region to have optical activity in the region.

The ellipsoid may have a minor diameter of 0.05 μm to 1 μm, specifically 0.1 μm to 1 μm, and more specifically 0.1 μm to 0.5 μm, and the ratio of the major axis to the minor axis may be 1 to 200, 1 to 100, or 1 to It may be 50 or 2 to 10, but is not limited thereto. In addition, the ellipsoid may have a thickness of 0.01 μm to 1 μm, specifically 0.05 μm to 1 μm, and more specifically 0.05 μm to 0.5 μm, but is not limited thereto.

In one embodiment, the chiral structure may have a maximum peak wavelength in the range of 800 nm to 1500 nm when measuring the circularly polarized dichroic spectrum, specifically in the range of 800 nm to 1200 nm or 900 nm to 1100 nm may appear

In one embodiment, the chiral nanoparticles are particles having inherent characteristics capable of self-assembly, and may be metal compounds. Specifically, the metal may be any one selected from Group 11 transition metals, and more specifically, the metal may be copper.

In one embodiment, the metal compound may include M _2-x A. In this case, M is a metal, A is a chalcogen element, and x is 0 < x ≤ 1. Specifically, the metal may be any one selected from Group 11 transition metals, and more specifically, the metal may be copper. The A may be any one selected from the group consisting of oxygen (O), sulfur (S), selenium (Se) and tellurium (Te), more specifically, the A may be sulfur (S) . By including M _2-x A, the chiral structure according to one embodiment may have optical activity in the near-infrared and short-infrared regions.

In one embodiment, the chiral nanoparticle may be prepared from a chiral ligand to impart chirality to the chiral structure. Any molecule having chirality may correspond to the chiral ligand without limitation, and specifically, it may be L-saccharide, D-saccharide, L-amino acid or D-amino acid. More specifically, the chiral ligand may be L-cysteine or D-cysteine, but is not limited thereto.

The chiral nanoparticles may have an average diameter of 1 nm to 20 nm or 1 nm to 10 nm, but are not particularly limited thereto. These nano-sized chiral nanoparticles are aggregated through self-assembly through interactions between nanoparticles to form a micro-sized chiral structure, so that atomic-level chirality is transferred to micro-level chirality. Thus, a chiral structure having optical activity in a wide range from the ultraviolet region to the short infrared region can be formed.

A precursor composition for preparing a chiral structure according to an embodiment is characterized in that it includes a chiral ligand, a metal precursor, and a chalcogen precursor.

By including a chiral ligand, a metal precursor, and a chalcogen precursor, the chiral structure prepared therefrom is a metal chalcogen compound prepared by the metal precursor and the chalcogen precursor due to the self-assembly characteristics of the chiral ligand at the atomic level. Irality is converted to micro-sized chirality, and it can have optical activity in a wide range from ultraviolet to short infrared.

The description of the chiral ligand may be applied to the above description, and to the metal of the metal precursor, the above-described description of the metal of the metal compound may be applied. In addition, the above description can be applied to the chalcogen element of the chalcogen precursor.

The metal precursor is not limited thereto, but may be a metal compound having a form of a metal chloride, hydroxide, carbonate, nitrate, or organic metal salt. For example, the salt may be selected from the group consisting of acetates, hydroxides, nitrates, fluorides, phosphates, perchlorates, nitrates, sulfates, iodines, chlorides, and combinations thereof.

The chalcogen precursor may include one or more elements selected from the group consisting of oxygen (O), sulfur (S), selenium (Se), and tellurium (Te). Specifically, the chalcogen precursor may be a sulfur precursor containing sulfur (S), and the sulfur precursor may be, for example, H ₂ S, C _1-10 alkylthiol, thiourea, thioacetamide ( thioacetamide) and sulfur-containing organic compounds or sulfur (S) elements, but are not limited thereto.

The precursor composition for preparing a chiral structure may further include an organic ligand, thereby further improving the stability of chiral nanoparticles prepared from the precursor composition for preparing a chiral structure, so that a chiral structure may be more easily formed.

The organic ligand is not particularly limited as long as it can improve the stability of chiral nanoparticles, but may be, for example, a ligand containing a thiol group, specifically C _4-12 alkylthiol, 2-(2-methoxy Ethoxy) ethanethiol, 3-methoxybutyl 3-mercaptopropionate, 3-methoxybutylmercaptoacetate, thioglycolic acid, 3-mercaptopropionic acid, tiopronin, 2-mercaptopropionic acid, 2- Mercaptopropionate, 2-mercaptoethanol, cysteamine, 1-thioglycerol, mercaptosuccinic acid, dihydrolipoic acid, 2-(dimethylamino)ethanethiol, 5-mercaptomethyltetrazole, 2,3 -Dimercapto-1-propanol, glutathione, m(PEG)-SH, di(C1-30)alkyldithiocarbamic acid, di(C1-30)alkyldithiocarbamate, or a combination thereof. More specifically, it may be thioglycolic acid.

A method for preparing a chiral structure according to an embodiment includes a first step of preparing chiral nanoparticles by reacting a precursor composition for preparing a chiral structure including a chiral ligand and a metal precursor; and a second step of preparing a micro-sized chiral structure by dispersing the chiral nanoparticles in a medium; It is characterized in that it includes.

In one embodiment, the chiral structure has a micro size of 10 ⁰ to 10 ² μm, and is not particularly limited as long as it has a size that can have optical activity in the ultraviolet region to the short infrared region, but, for example, the major axis is 1 μm to 10 μm, 1 μm to 5 μm, or 1 μm to 3 μm.

In one embodiment, the chiral structure may have optical activity in the ultraviolet-visible (UV-Vis) region, the near infrared (NIR) region, and the short infrared (SWIR) region.

The first step is a step of preparing chiral nanoparticles by reacting a precursor composition for preparing a chiral structure including a chiral ligand and a metal precursor, which can be reacted by a known method, and for example, in an oxygen-blocked atmosphere and 30 It may be carried out by stirring in the temperature range of ℃ to 100 ℃, but there is no particular limitation to the method. The oxygen blocking method is not limited thereto, but, for example, the precursor composition for preparing a chiral structure may be purged with an inert gas such as nitrogen in an airtight container.

In the first step, the above description can be applied to the chiral ligand, metal precursor, chalcogen precursor, and chiral nanoparticles.

In one embodiment, the molar ratio of chiral ligand:metal precursor:chalcogen precursor may be 1:0.1 to 0.8:0.1 to 0.6, specifically 1:0.2 to 0.8:0.1 to 0.5, more specifically 1 : 0.3 to 0.5 : 0.1 to 0.3, but is not particularly limited thereto.

In one embodiment, the second step is a step of preparing a micro-sized chiral structure by dispersing the chiral nanoparticles prepared in the first step in a medium, and the chiral nanoparticles are produced by the dispersion process in the medium. Self-assembly may occur to produce micro-sized chiral structures. Micro-sized chiral structures can be more easily prepared by using the self-assembly phenomenon of the chiral nanoparticles.

The medium is a material capable of dispersing chiral nanoparticles, and may be, for example, an aqueous phase, but is not limited thereto.

The second step may include a dispersing step of dispersing the chiral nanoparticles prepared in the first step in a medium and a aging step of aging the chiral nanoparticles dispersed in the medium, and the aging step is performed at 20 ° C to 40 ° C. It may be carried out at ℃ or 20 ℃ to 30 ℃, but is not limited thereto.

One embodiment provides a biosensor including the chiral structure as described above, wherein the biosensor includes a chiral structure having optical activity in a wide range from the ultraviolet region to the short-infrared region. Since the interaction with light of the area can be used, it can be applied in various fields such as diagnosis technology, heat treatment technology, and imaging technology of cancer cells or bone tissue, for example.

In addition, one embodiment provides an optical device including a chiral structure as described above, wherein the optical device includes a chiral structure having optical activity in a wide range from an ultraviolet region to a short infrared region. Compared to conventional materials that have limited optical activity only in the ray domain, they can be used in a wider variety of ways.

Hereinafter, examples and experimental examples of the present invention will be specifically illustrated and described. However, Examples and Experimental Examples to be described later are merely illustrative of a part of the present invention, and the present invention is not limited thereto.

[Physical property evaluation method]

1. Circular polarization = dichroic (CD) spectrum measurement

Circular dichroism (CD) measurements were performed using a J-1700 circular polarization/dichroism spectrophotometer (JASCO company) operating in the wavelength range of 200 nm to 2500 nm. The synthesized sample for CD measurement was redispersed in distilled water to measure the optical activity in the UV-Vis-NIR region (200 nm to 800 nm). In addition, the sample was drop-casted on a quartz wafer to measure the optical activity in the UV-Vis-NIR-SWIR region (200 nm to 2500 nm).

2. X-ray photoelectron spectroscopy (XPS) analysis

Samples were prepared by drop casting 20 μl of the dispersion aged for 0, 2, and 20 hours on a silicon wafer substrate, and subjected to X-ray photoelectron spectroscopy using a K-alpha spectrometer (Thermo VG Scientific company). , XPS) analysis was performed.

3. Scanning Electron Microscopy (SEM) Imaging

Samples were prepared by drop casting on a silicon wafer, and scanning electron microscopy (SEM) imaging was performed using a Magellan400 (FEI Company) at a voltage of 10 kV and a current of 7 μA.

4. Transmission electron microscopy (TEM) imaging

Samples were prepared by dropping and drying on a nickel grid coated with a porous carbon film, and subjected to transmission electron microscopy (TEM) imaging using a Talos F200X (FEI Company) at a voltage of 200 kV.

<Example 1> Preparation of L-Cys-Cu _2-x S NF

First, 20 ml of distilled water was put into a three-necked flask, and dissolved oxygen was removed through a nitrogen purging process for 30 minutes. After raising the temperature to 70 ° C. in an oxygen-blocking state, 0.033 ml (0.45 mmol) of Thioglycolic acid (TGA) and 2 ml (0.55 mmol) of L-cysteine were added, followed by nitrogen purging for 30 minutes with stirring. 0.02475 g (0.25 mmol) of Copper(I) chloride was added to the flask and nitrogen purging was performed for 1 hour. Then, after adjusting the pH of the solution in the flask to 9 using NaCl, 1 ml (0.125 mmol) of Thioacetamide (TAA) was added and reacted for 4 hours to obtain brownish chiral copper sulfide nanoparticles (or L- A first solution containing Cys-Cu ₂ S NP) was prepared.

The prepared first solution and isopropanol were mixed at a volume ratio of 2:1 and centrifuged at 8500 rpm for 20 minutes to obtain chiral copper sulfide nanoparticles (or L-Cys-Cu ₂ S NPs). At this time, it was confirmed that the obtained chiral copper sulfide nanoparticles had an average diameter of 4.48 nm as a result of image analysis using a high-resolution transmission electron microscope (HR-TEM). Thereafter, the nanoparticles obtained through centrifugation were redispersed in 20 ml of tertiary distilled water and aged at room temperature for 20 hours to obtain a second solution. Then, the second solution and isopropanol were mixed at a volume ratio of 1:1 and centrifuged twice at 6000 rpm for 10 minutes to prepare a micro-sized chiral structure (or L-Cys-Cu _2-x S NF). .

<Example 2> Preparation of D-Cys-Cu _2-x S NF

A micro-sized chiral structure (or D-Cys-Cu _2-x S NF) was prepared in the same manner as in Example 1, except that D-cysteine was used instead of L-cysteine in Example 1.

A micro-sized structure (or DL-Cys-Cu _2-x S nanobowties) were prepared.

<Experimental Example 1> UV-Short Infrared Broad Range Chirality

1 is a schematic diagram showing a process of synthesizing and self-assembling chiral copper sulfide nanoparticles using cysteine (Cys). Referring to FIG. 1 , the chirality of cysteine molecules is transferred to chiral copper sulfide nanoparticles to synthesize nanoparticles having optical activity in the ultraviolet-visible region. As the nanoparticles undergo self-assembly and the ellipsoid is rotated in a certain direction, a nanoflower-shaped structure is formed, and chirality is transferred to the micro level, resulting in a micro-sized structure having optical activity in the ultraviolet-visible-short-infrared region. is finally synthesized.

2 is an SEM image of the structures of Example 1, Example 2, and Comparative Example 1, and referring to this, it can be seen that the final synthesized structure has a shape in which a plurality of ellipsoids are stacked. Example 1 exhibits enantioselection in which ellipsoids are stacked in a counterclockwise direction using L-cysteine during synthesis and in a clockwise direction using D-cysteine in Example 2. On the other hand, in the case of Comparative Example 1, a structure in the form of a nanobowtie having a symmetrical structure without chirality was formed by using the same amount of L-cysteine and D-cysteine.

3 and 4 are g constant graphs and circular dichroism (CD) graphs of structures of Examples 1, 2, and Comparative Example 1, respectively. Referring to FIGS. 3 and 4 , the structures of Example 1 and Example 2 have mirror image structures, so they are symmetrical to each other in the CD graph. In particular, referring to the CD measurement results, CD peaks appear in the ultraviolet region (249 nm, 315 nm), near infrared region (1007 nm), and short infrared region (2140 nm). It can be confirmed that a chiral structure having optical activity was successfully synthesized.

<Experimental Example 2> Confirmation of chirality transition

5, 6 and 7 are diagrams for explaining a series of processes in which chirality transition occurs in the self-assembly process. Referring to FIG. 5, nanoparticles synthesized through TEM images according to aging time form supraparticles after 1 hour, pearl-necklace aggregates after 2 hours, and 5 hours After that, it can be confirmed that the aggregate changes into an ellipsoid having a nanoleaf shape. After 10 hours, ellipsoids predominately exist, and after 20 hours, a structure in which ellipsoids are stacked is formed.

Referring to FIGS. 6 and 7 , it can be seen that CD peaks corresponding to longer wavelength bands are generated as the aging time elapses. Through this, it can be seen that a chiral transition occurs during the self-assembly process.

8 is a CD graph of the cysteine molecules, chiral nanoparticles, and chiral structures of Examples 1 and 2, through which chirality at the atomic level is transferred to the chiral nanoparticles, resulting in nano-level chirality, It can be seen that the nano-level chirality is transferred to the micro-sized chiral structure, and thus the micro-level chirality is obtained. A chiral structure using such a self-assembly process satisfies both essential elements for having a wide range of optical activity from the ultraviolet to the short-infrared region: 1) a micro-sized material and 2) a chiral center, making it easier can be manufactured.

<Experimental Example 3> Optical activity control according to the use ratio of organic ligand and cysteine

9 is chiral synthesized when the molar ratio of TGA and L-cysteine, which are organic ligands, was used in Example 1 at 4:6, 3:7, 2:8, and 0:10, which are different from the molar ratio of 4.5:5.5. SEM images of the structures, and FIGS. 10 and 11 are g factor graphs and CD graphs measuring the optical activity of the synthesized chiral structures, respectively. As a result, as the use ratio of L-cysteine increased, the size of the chiral structure synthesized through self-assembly increased, and specifically, the size was found to be 3 μm to 6 μm.

According to the tendency to interact with light of a wavelength similar to the size of the material, as the use ratio of L-cysteine increases, the size of the chiral structure increases, and it can be seen that the CD peaks are red-shifted as a whole. Therefore, it can be seen that a chiral structure having optical activity in a desired wavelength range can be synthesized by adjusting the ratio of organic ligand and L-cysteine during synthesis.

As described above, the present disclosure has been described by specific details and limited embodiments in this specification, but this is only provided to help a more general understanding of the present disclosure, the present disclosure is not limited to the above embodiments, and the present disclosure Those skilled in the art can make various modifications and variations from these descriptions.

Therefore, the ideas described in this specification should not be limited to the described embodiments and should not be determined, and all things equivalent or equivalent to the claims as well as the following claims fall within the scope of the ideas described in this specification. will do it

Claims

Including chiral nanoparticles,

A chiral structure having optical activity in the ultraviolet-visible (UV-Vis) region, the near infrared (NIR) region, and the short infrared (SWIR) region.
According to claim 1,

The chiral structure is a superparticle assembly prepared by self-assembly of the chiral nanoparticles.
According to claim 1,

The chiral structure includes two or more ellipsoids and has a structure in which the ellipsoids are stacked while rotating clockwise or counterclockwise.
According to claim 3,

The ellipsoid has a major diameter of 1 μm to 10 μm, a chiral structure.
According to claim 1,

A chiral structure in which the maximum peak wavelength appears in the range of 800 nm to 1500 nm when circularly polarized light = dichroic spectrum is measured.
According to claim 1,

The chiral nanoparticle is a metal compound, a chiral structure.
According to claim 6,

The metal is any one selected from group 11 transition metals, chiral structure.
According to claim 1,

The chiral nanoparticle is prepared from a chiral ligand, a chiral structure.
According to claim 8,

The chiral ligand is an L-amino acid or a D-amino acid.
According to claim 1,

The chiral nanoparticles have an average diameter of 1 nm to 10 nm, a chiral structure.
A precursor composition for preparing a chiral structure comprising a chiral ligand, a metal precursor and a chalcogen precursor.
According to claim 11,

The chiral ligand is an L-amino acid or a D-amino acid, a precursor composition for preparing a chiral structure.
According to claim 12,

The chiral ligand is L-cysteine or D-cysteine, a precursor composition for preparing a chiral structure.
A first step of preparing chiral nanoparticles by reacting a precursor composition for preparing a chiral structure including a chiral ligand and a metal precursor; and

a second step of preparing a micro-sized chiral structure by dispersing the chiral nanoparticles in a medium; A method for producing a chiral structure comprising a.
According to claim 14,

The precursor composition for preparing the chiral structure further comprises a chalcogen precursor.
According to claim 15,

The molar ratio of chiral ligand: metal precursor: chalcogen precursor is 1: 0.1 to 0.8: 0.1 to 0.6, a method for producing a chiral structure.
According to claim 14,

In the second step, the chiral nanoparticles are self-assembled to produce a micro-sized chiral structure.
A biosensor comprising the chiral structure according to any one of claims 1 to 10.
An optical device comprising the chiral structure according to any one of claims 1 to 10.